System for non-invasive continuous blood glucose measurement using multi-wavelength optical spectroscopy

Abstract

A system for the non-invasive, continuous determination of blood glucose concentration, comprising: a housing structure configured to come into contact with the skin surface of a subject; a plurality of luminescent elements arranged within the housing structure, each luminescent element configured to emit optical radiation at a specific wavelength from the visible, near-infrared, and short-wave infrared spectral ranges; a control unit electrically connected to the numerous luminescent elements and configured to control the sequential or simultaneous emission of the optical radiation; a photodetection arrangement comprising at least one photodetector positioned to receive optical signals reflected from or transmitted through a tissue area;a signal acquisition unit configured to convert the received optical signals into digitized intensity data corresponding to each emitted wavelength; a preprocessing unit configured to perform normalization, ambient light correction, and motion artifact suppression on the digitized intensity data; a spectral decomposition unit configured to separate the composite optical absorption contributions of multiple tissue components and extract glucose-correlated spectral features; a processing unit configured to estimate blood glucose concentration by correlating the extracted spectral features with a stored computational model;and a calibration unit configured to dynamically update the parameters of the computational model based on temporal fluctuations and subject-specific characteristics, the system being configured to enable continuous and real-time glucose determination without the need for invasive sample collection.

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