Fluorosubstantiated porphyrin compounds, pharmaceutical compositions containing them and methods for their manufacture and use
Patent Information
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- DUKE UNIV
- Filing Date
- 2018-09-26
- Publication Date
- 2026-04-15
AI Technical Summary
The synthesis of fluoro-porphyrins is challenging due to harsh reaction conditions, unwanted byproduct formation, and low selectivity and stability of fluorine-containing intermediates, as well as the lack of generality and predictability in fluorination methods, as highlighted by existing literature.
Development of fluoro-substituted porphyrin compounds represented by Formulas II through X, which include specific structures with anion X as PF6- or Cl-, offering improved bioavailability, safety, and toxicity profiles, and enhanced therapeutic properties.
The fluoro-substituted porphyrins demonstrate superior redox properties, increased catalytic potency, and improved therapeutic efficacy, including tumor growth inhibition and radiation protection, with reduced side effects and enhanced bioavailability compared to non-fluorinated analogs.