Display of the NO dose by a device for the provision of NO during the rest period

Description

[0001] The invention relates to a device or apparatus for supplying gaseous nitric oxide (NO), in particular a mixture of NO and nitrogen (N 2 ), and to an installation for administering NO to a patient comprising such a NO supply device.

[0002] Inhaled nitric oxide or iNO is a gaseous drug commonly used to treat patients with acute pulmonary arterial hypertension, particularly pulmonary vasoconstrictions in adults or children, including newborns (PPHN), as described for example by EP-A-560928 or EP-A-1516639.

[0003] An installation for implementing NOi treatment, commonly called a NO administration installation, conventionally comprises one or more NO / N 2 mixture cylinders supplying a NO supply device which delivers the NO / N 2 mixture at a controlled flow rate, a respiratory assistance device, also called a medical ventilator, to supply a respiratory gas containing at least 21% vol. of oxygen, such as an O 2 / N 2 mixture or air, to which is added the NO (i.e. the NO / N 2 mixture) supplied by the NO supply device, circuit elements, for example one or more flexible conduits, to convey the gas flows between these different pieces of equipment and to the patient, and a respiratory interface, such as a tracheal tube, to supply the gas mixture containing the NO to the patient. A gas humidifier may also be provided to humidify the gas mixture before its administration to the patient. Such an installation is shown diagrammatically in Fig. 1 .

[0004] Typically, the NO / N 2 mixture delivered by the NO delivery device is injected into the respiratory stream containing at least 21% vol. of oxygen (i.e. air or O 2 / N 2 mixture) from the medical ventilator before being administered by inhalation to the patient in the form of a final respiratory mixture (i.e. NO / N 2 / O 2 or NO / N 2 / air mixture) generally containing a few tens ppmv of NO (ppm by volume) and at least 21% vol. of oxygen O 2 , for example of the order of 1 to 80 ppmv of NO, the remainder being essentially nitrogen (N 2 ).

[0005] Such a NO administration facility is used in a hospital setting to administer NOi treatment and thus treat patients who need to inhale NO to treat their pulmonary arterial hypertension. Examples of such NO administration facilities are given by documents EP3906954A1, WO-A-2012 / 094008, US-A-2015 / 320951, US-A-2015 / 273175, JP-A-H11192303, WO-A-02 / 40914 and US-A-2003 / 116159.

[0006] In particular, the NO-based drug is indicated in the treatment of patients with an acute attack of pulmonary arterial hypertension, which is a severe clinical situation during which the patients' life prognosis is at risk.

[0007] During NOi treatment, NO must be provided according to a precise dosage and preferably in an interrupted manner between the start and end of NOi treatment.

[0008] However, during the course of NOi treatment, pauses in the delivery system may be necessary or even essential, for example when the patient is temporarily disconnected from the ventilation system in order to undergo other medical care, such as bronchial suctioning or other procedures.

[0009] Today, known inhaled NO delivery devices display the NO dose being delivered, i.e. the desired NO dose selected by the healthcare provider and delivered for the duration of the actual treatment.

[0010] However, pausing these known NO delivery devices requires resetting the dose of NO to be administered to the patient, failing which, NO continues to be supplied by the NO delivery device for the entire duration of the pause, typically several minutes, or even tens of minutes, which would obviously not be desirable.

[0011] Then, when the treatment is resumed, the medical staff must again indicate to the NO administration device the desired dose of NO to be administered during the remainder of the treatment. However, this procedure is not satisfactory because it creates risks for patients. Indeed, the medical team can make a setting error or even a prescription error if they forget the dose set before pausing the NO administration device.

[0012] Patients are then exposed to the risk of receiving a dose of NO that does not comply with the prescription, when NO administration is resumed, i.e. at the end of the pause.

[0013] A problem is therefore to be able to avoid or limit errors in the setting or prescription of NO by the nursing staff, when resuming NO treatment which has been paused for typically several minutes, or even tens of minutes, so as to reduce the risks for the patient of being administered a dose of NO which does not comply with their prescription.

[0014] A solution of the invention then concerns a device for supplying NO, comprising: an internal passage for conveying a gas flow containing NO, typically a NO / N 2 gas mixture, valve means for controlling the gas flow in the internal passage, control means for controlling at least the valve means, dose selection means configured to allow a user to choose or adjust a dose of NO to be administered, storage means configured to store at least said dose of NO to be administered, treatment start means operable by the user and cooperating with the control means to start or resume NO treatment, treatment stop means operable by the user and cooperating with the control means to pause or definitively stop NO treatment, and a graphic display configured to display the dose of NO to be administered before the start of NO treatment or the dose administered to the patient during NO treatment.

[0015] According to the invention, the graphic display is further configured to continue to display the dose of NO having been administered to the patient, during a pause period (dt) during which the treatment with NO is temporarily interrupted, i.e. during a pause, in response to actuation by the user of the treatment stopping means.

[0016] Depending on the embodiment considered, the device of the invention may comprise one or more of the following characteristics: the control means are further configured to control the valve means to provide a gas flow rate corresponding to the dose of NO to be administered during the NO treatment, in response to the user actuating the treatment start means. the control means are further configured to control the valve means to temporarily interrupt, during the pause period (dt), any gas flow rate in response to the user actuating the treatment stop means. the control means are configured to control the graphic display to display the dose of NO to be administered, before and during the NO treatment and during the pause period (dt) during which the NO treatment is temporarily interrupted. the control means are configured to control the graphic display to continue to display, during the pause period (dt), the dose of NO having been administered to the patient just before (i.e.immediately before) actuation by the user of the treatment stopping means, i.e. before pausing. the control means are configured to control the graphic display to display an adjusted dose of NO to be administered to the patient, after the pause period (dt), said adjusted dose of NO being chosen or adjusted by the user, during the pause period (d), via the dose selection means. the pause period (dt) has a duration less than or equal to 30 minutes, preferably between 1 and 20 minutes approximately. the storage means are configured to store the last dose of NO administered to the patient immediately before the start of the pause period (dt), i.e. before pausing. the treatment starting means and the treatment stopping means comprise a single and same actuating member, operable by the user.alternatively, the treatment start means and the treatment stop means comprise separate actuating members, operable by the user. the actuating member(s) comprise one or more keys, buttons, rotary selectors, sliders or the like. the actuating member(s) comprise one or more virtual selection keys displayed on the graphic display. the graphic display is configured to display one or more virtual keys. the graphic display is a touch-controlled digital display screen. the control means comprise at least one (micro)processor. the dose selection means comprise at least one touch-sensitive selection key displayed on the display screen. the display screen is configured to display said at least one touch-sensitive selection key, preferably several touch-sensitive selection keys.the touch selection key(s) are configured to allow a choice to be made from several proposed NO contents or alternatively, include “+” and “-” keys allowing a given NO value to be incremented or decremented in steps, for example by 0.1 ppmv or 1 ppmv, or other (eg 2 in 2 ppmv, 3 in 3 ppmv... or 5 in 5 ppmv..). said desired NO content which is chosen or selected by the user by action on said touch selection key is supplied to the control means, preferably by digital action. the selection or setting of the desired NO dose is done by digital pressure by the user on the touch-activated selection key(s) displayed on the display screen. the NO dose selection means are configured to allow the user to set or select a desired NO content between 0.1 and 80 ppmv. the display screen is color or black and white.the control means are configured to control the display(s) on the graphic display, i.e. the information display screen. the control means comprise one or more (micro)processors, for example a microcontroller. the control means comprise at least one electronic card comprising said at least one microprocessor. the control means comprise at least one (micro)processor implementing at least one algorithm, for example for data processing, calculation or other. the virtual key(s) displayed on the graphic display are touch keys. the graphic display has a touch screen.

[0017] According to another aspect, the invention also relates to an installation for administering therapeutic gas containing NO to a patient (P) comprising a NO supply device according to the invention, in particular as described above, supplied with NO / N 2 mixture by at least one pressurized gas container and with oxygen by a pressurized oxygen container, said NO supply device supplying a NO / N 2 mixture to a respiratory gas circuit connected to a medical ventilator supplying an O 2 / N 2 mixture or air.

[0018] Depending on the embodiment considered, the therapeutic gas administration installation of the invention may comprise one or more of the following characteristics: the NO supply device may comprise a main outlet supplying the NO / N 2 mixture to the respiratory gas circuit connected to the medical ventilator, preferably via a NO injection conduit or NO injection line, i.e. a flexible hose or the like. said at least one pressurized gas container contains the NO / N 2 mixture. said at least one pressurized gas container contains a NO / N 2 mixture containing from 100 to 1000 ppmv of NO, the remainder being nitrogen. the pressurized oxygen container contains medical oxygen. the container(s) are gas cylinders. the gas container(s) contain a NO / N 2 mixture or medical oxygen at a pressure of at least 150 bar, or even at least 180 bar. the respiratory gas circuit comprises (at least) an inspiratory branch and an expiratory branch.the inspiratory branch and the expiratory branch are fluidically connected to each other via a connecting piece, such as a Y-piece. the connecting piece is fluidically connected to a respiratory interface, such as a tracheal tube, a breathing mask or oxygenation goggles. the inspiratory branch and the expiratory branch comprise flexible hoses. a gas humidifier is arranged on the respiratory gas circuit, in particular on the inspiratory branch. the inspiratory branch comprises a flow sensor electrically and / or via tubing connected to the NO supply device, in particular to the control means. the flow sensor is arranged on the inspiratory branch upstream of the NO injection site. the flow sensor is of the mass or pressure differential type.a gas sampling line fluidly connects the NO supply device to the respiratory gas circuit, preferably near the junction piece, ie the Y-piece. the medical ventilator and the NO supply device are electrically powered by at least one source of electric current. the NO supply device may comprise an emergency outlet, ie a secondary outlet, for example a port or an orifice, which can be fluidically connected to a manual insufflation bag.

[0019] Generally speaking, within the scope of the invention, the terms "means of" or "means to" are considered equivalent and substitutable for the terms "device of", "device to" or the like. For example, the terms "valve means" are considered equivalent and substitutable for the terms "valve device", the terms "control means" are considered equivalent and substitutable for the terms "control device", etc.

[0020] The present disclosure also relates to a method (not claimed) for therapeutic treatment of a patient, in which a device for supplying NO according to the invention and / or an installation for administering therapeutic gas containing NO to a patient (P) is used, comprising a device for supplying NO according to the invention, in particular as described above, for administering by inhalation a therapeutic gas containing nitric oxide or NO (i.e. a gaseous drug) to the patient to be treated, said patient suffering from pulmonary arterial hypertension, in particular pulmonary vasoconstrictions.

[0021] Depending on the embodiment considered, the processing method may comprise one or more of the following features: The patient is an adult, adolescent, child, newborn, or infant. The patient has acute pulmonary hypertension. The patient has persistent pulmonary hypertension of the newborn (PPHN or Persistent Pulmonary Hypertension of the Newborn ) .Pulmonary hypertension is perioperative and associated with cardiac surgery. The therapeutic gas containing nitric oxide (NO) is administered at a concentration below 40 ppmV. The therapeutic gas contains nitric oxide (NO), nitrogen, and oxygen (at least about 21% vol.), and possible impurities. The therapeutic gas containing nitric oxide (NO) is administered via a tracheal intubation tube or the like. The NO delivery device is supplied by at least one pressurized gas container, e.g., a gas cylinder, containing an NO / N 2 mixture containing 100 to 1000 ppmv of NO, the remainder being nitrogen. The gas delivery system comprises a medical ventilator providing a gas containing oxygen (at least about 21% vol.), e.g., an O 2 / N 2 mixture, or air.

[0022] The invention will now be better understood thanks to the following detailed description, given for illustrative but non-limiting purposes, with reference to the appended figures among which: Fig. 1 represents an embodiment of an installation for administering therapeutic gas to a patient incorporating an NO supply device according to the invention, Fig. 2 represents an embodiment of the graphic display of an NO supply device according to the invention showing the information displayed during NO treatment, for example by means of the installation of Fig. 1 , And Fig. 3 represents an embodiment of the graphic display of an NO supply device according to the invention showing the information displayed during a pause period during which the NO treatment is temporarily interrupted.

[0023] Fig. 1 schematizes an embodiment of an installation 100 for administering therapeutic gas, i.e. a gas mixture based on NO, typically a NO / O 2 / N 2 mixture, to a patient P incorporating the NO 1 supply device according to the present invention.

[0024] More specifically, it comprises here two pressurized gas containers 5, arranged in parallel, each containing a gas mixture of NO and nitrogen (N 2 ), i.e. a NO / N 2 mixture, typically containing from 250 to 1000 ppmv of NO and nitrogen (N 2 ) for the remainder conditioned at a pressure of up to 180 bar or more, for example a NO / N 2 mixture, containing 450 ppmv or 800 ppmv of NO. Such gas containers 5 are commonly called NO 5 cylinders.

[0025] The NO 5 cylinders supply the NO / N 2 mixture to the NO 1 supply device according to the invention. They are fluidically connected to the gas supply device 1 by NO supply lines 50, i.e. gas pipes, such as flexible hoses or the like. Each NO supply line 50 is connected to an NO inlet port 101 of the NO 1 supply device to supply a main gas circuit 200 internal to the housing 103 of the NO 1 supply device.

[0026] The housing 103 of the NO 1 supply device also comprises a graphic display 10, such as a touch screen, configured to display various information, in particular the doses of NO, as explained below and illustrated in Fig. 2 And Fig. 3 .

[0027] The NO 1 supply device also comprises an oxygen inlet port 102 fluidically connected, via an oxygen supply line 51, such as a flexible hose or the like, to an oxygen source, for example a pressurized oxygen container 52, typically an O 2 cylinder or, alternatively, the hospital network, i.e. an oxygen supply pipe arranged in the hospital building where the patient P is being treated.

[0028] The NO 5 cylinders and the O 2 cylinder 52 are equipped with a gas distribution valve 55, preferably incorporating gas expansion means, i.e. an RDI or integrated pressure reducing valve, so as to be able to control the flow rate and / or pressure of the gas they deliver. The gas distribution valve 55 is preferably protected against impacts by a protective cover.

[0029] Furthermore, the installation 100 also comprises a medical ventilator 2, i.e. a respiratory assistance device, providing a flow of respiratory gas containing at least 21% vol. of oxygen, such as air or an oxygen / nitrogen mixture (N 2 / O 2 ), to the patient P.

[0030] The medical ventilator 2 is fluidically connected to the patient P via a respiratory gas circuit 3 which here has two respiratory branches 30, 31 given that it comprises an inspiratory branch 30, that is to say a gas supply line, used to bring the respiratory gas to the patient P and an expiratory branch 31 used to recover the CO 2 -enriched gas exhaled by the patient P.

[0031] The two respiratory branches 30, 31 are typically flexible tubes made of polymer or the like. The two respiratory branches 30, 31 are, on the one hand, connected to the medical ventilator 2 and, on the other hand, connected to each other at a junction piece 32, typically a Y-piece, which is in fluid communication with a respiratory interface 4 supplying the gas to the patient P, such as a tracheal tube or the like.

[0032] Of course, the medical ventilator 2 and the NO 1 supply device are normally electrically powered by one or more sources of electrical current, in particular their components requiring electrical energy to operate, in particular the means for controlling the NO 1 supply device and the control system of the medical ventilator 2, i.e. electronic card with microprocessor(s), or any other component, in particular the internal motorized turbine which supplies the air flow or the like, i.e. the respiratory gas. The source of electrical current may be the mains (110 / 220V) and / or an electric battery, preferably rechargeable.

[0033] As can be seen, the NO 1 supply device makes it possible to inject the NO / N 2 mixture into the inspiratory branch 30, via an NO 11 injection conduit opening into the inspiratory branch 30 at an injection site 8, so as to produce a mixture of the NO / N 2 flow and the flow of respiratory gas containing at least 21% O 2 , i.e. air or oxygen / nitrogen mixture, delivered by the medical ventilator 2.

[0034] The NO 1 supply device comprises a main outlet orifice 104 located at the outlet of its main gas circuit through which the NO / N 2 flow leaves the housing 103 of the NO 1 supply device and enters the NO 11 injection conduit. The NO 11 injection conduit is fluidically connected to the main outlet orifice 104, for example via a connector or the like.

[0035] The resulting therapeutic gas mixture therefore contains oxygen (>21% vol.), nitrogen and a variable and adjustable NO concentration, typically between 1 and 80 ppmv, due to the dilution of the product during the mixing of the gas flows. Of course, unavoidable impurities may be found in the gas but they are not desired, particularly when the gas flow from the ventilator 2 is atmospheric air rather than an O 2 / N 2 mixture.

[0036] Advantageously, a gas humidifier 6 is also provided, arranged here on the inspiratory branch 30 downstream of the injection site 8, serving to humidify the flow of therapeutic gas, e.g. NO / N 2 / O 2 mixture, by adding water vapor, before it is inhaled by the patient P, which makes it possible to avoid or limit the drying out of the respiratory tract of the patient P during his treatment by inhalation of the gas.

[0037] According to another embodiment, the gas humidifier 6 could also be arranged upstream of the injection site 8.

[0038] Depending on the case, the expiratory branch 31 used to collect the CO2-rich exhaled gases may comprise one or more other optional components, such as for example a CO2 elimination device, i.e. a CO2 trap, such as a hot tank or other, making it possible to eliminate the CO2 present in the gases exhaled by the patient, a filter or other.

[0039] Also provided on the inspiratory branch 30, upstream of the injection site 8, is a flow sensor 7, for example of the mass or pressure differential type, connected to the NO 1 supply device, in particular to the means for controlling said NO 1 supply device, via a respiratory gas flow measurement line 71 used to measure the gas flow coming from the ventilator 2 within the inspiratory branch 30.

[0040] Determining this fan flow rate makes it possible in particular to regulate the passage of NO through the NO 1 supply device, in particular to be able to choose the flow rate of NO / N 2 mixture to be injected according to the desired NO content, the composition of the NO / N 2 mixture coming from the bottles and the gas flow rate (i.e. air or air / O 2 ) coming from fan 2.

[0041] Furthermore, it is also possible to provide a gas sampling line 33 fluidly connecting the NO 1 supply device to the respiratory gas circuit 3, preferably close to the Y-piece 32, for example approximately 10 to 20 cm upstream of the Y-piece 32, used to take gas samples and to check, by means of a gas analyzer or the like, their conformity with the desired gas mixture to be administered to the patient P.

[0042] More specifically, the NO supply device 1 comprises a main internal gas circuit for conveying the NO / N 2 mixture entering through the gas inlet port(s) 101 to the NO injection conduit 11. This main gas circuit comprises NO / N 2 flow control means, namely valve means, such as valves, calibrated orifices, etc., controlled by the control means of the NO supply device 1, typically one (or more) microprocessors arranged on an electronic card, the operation of which is explained below. All these components are arranged in the housing 103, i.e. a rigid external casing.

[0043] The control means of the NO supply device 1 also control the displays on the display 10, such as a touch screen, preferably in color.

[0044] In addition, the NO supply device 1 may also comprise a backup circuit, called a “backup” circuit, designed to deliver an adjustable O2 flow rate and a fixed NO flow rate in order to be able to ensure a supply of NO, even in the event of a breakdown or other event.

[0045] According to the present invention, the NO 1 supply device further comprises dose selection means, such as a virtual key displayed on the display 10, configured to allow a user to choose or adjust a dose of NO to be administered, and storage means configured to store the dose of NO to be administered, or even other information.

[0046] In addition, it also includes processing start means 120 operable by the user, such as a virtual key displayed on the display 10 as seen in Fig. 3 , which cooperate with the control means to start or resume NO treatment by controlling the valve means to provide the desired dose of NO.

[0047] By analogy, it also includes treatment stopping means that can be activated by the user, such as a virtual key displayed on the display 10, which also cooperate with the control means to pause or definitively stop a NO treatment by controlling the valve means to interrupt the passage and supply of NO / N 2 mixture to the ventilation circuit connected to the ventilator 2.

[0048] The graphic display 10 is, for its part, configured to display the dose of NO to be administered (at 110, 111) before the start of the NO treatment or the dose administered to the patient P, during the NO treatment. The displays on the graphic display 10 are controlled by the control means of the NO supply device 1 of the invention.

[0049] However, according to the invention, the graphic display 10 is further configured to continue to display the dose of NO having been administered 110 to the patient, throughout a pause period (dt) during which the treatment with NO is temporarily interrupted, that is to say during a pause which can last several minutes or tens of minutes, typically less than 45 minutes, for example up to approximately 20 to 30 minutes. The pause begins as soon as the user actuation of the treatment stopping means.

[0050] Fig. 2 represents an embodiment of the graphic display 10 of the NO supply device 1 according to the invention showing the information displayed during the course of an NO treatment, for example by means of the installation of Fig. 1 .

[0051] As can be seen, during the treatment of a patient by administration of NO, the display 10 displays various information useful to the nursing staff, in particular: the dose of NO to be administered (in 110) to the patient, namely here 10 ppm by volume for example, which is chosen before the start of the treatment; the dose of NO actually administered (in 111) to the patient during the treatment by NO, namely here 8 ppm by volume for example, that is to say the dose of NO after mixing the NO / N 2 mixture supplied by the device 1, with the gas coming from the ventilator 2, such as an N 2 / O 2 mixture or air; the quantity of NO 2 formed, namely here 0.1 ppm by volume, present in the final mixture administered to the patient; and the oxygen content, namely here 25% by volume, present in the final mixture administered to the patient.

[0052] The display 10 of the device 1 also displays other information, such as curves 114 for monitoring the NO, O 2 and NO 2 contents, during the treatment by administration of NO to the patient P.

[0053] In other words, the dose of NO set by the healthcare team is permanently visible (at 110), when the administration of NO is in progress, and the graphic display 10 also displays the dose actually delivered (at 111) which is measured by the gas analyzer supplied by the gas sampling line 33.

[0054] Fig. 3 represents the information displayed on the graphic display 10 of the NO supply device 1 according to the invention, during a pause period during which the NO treatment is temporarily interrupted, i.e. after a pause.

[0055] In this case, the dose of NO supplied is equal to 0 ppm (in 111) but in accordance with the invention, the graphic display 10 continues, despite the pause, to display the dose of NO (in 110) having been administered to the patient during the treatment phase, namely here 10 ppmv.

[0056] This display (at 110) is operated throughout the pause period (dt) during which the NO treatment is temporarily interrupted, after actuation by the user of treatment stopping means, such as a touch key displayed on the graphic display 10, such as a digital touch screen.

[0057] Treatment start means 120, such as a touch key displayed on the graphic display 10, makes it possible to resume, i.e. to continue, the treatment by NO when it is actuated by the user, i.e. when he presses it with his finger.

[0058] In this case, the nursing staff does not risk making a mistake when resuming treatment since the last known dose of NO provided to the patient is permanently displayed for the duration of the break and until treatment is resumed.

[0059] Optionally, the healthcare staff can modify it before restarting treatment.

Claims

1. NO supply device (1) comprising: - an internal passage for conveying a gaseous flow containing NO, typically a gaseous mixture NO / N2, - valve means for controlling the gaseous flow in the internal passage, - control means for controlling at least the valve means, - dose selection means configured to allow a user to choose or adjust an NO dose to be administered, - memory storage means configured to store at least said NO dose to be administered, - means (120) for starting treatment, which means are actuatable by the user and cooperate with the control means in order to initiate or resume a treatment by NO, - means for stopping treatment, which means are actuatable by the user and cooperate with the control means in order to pause or definitively discontinue a treatment by NO, and - a graphic display (10) configured to display, before the commencement of the treatment by NO, the NO dose to be administered (110; 111), or to display, during the treatment by NO, the dose administered to the patient, characterized in that the graphic display is additionally configured to continue to display the NO dose having been administered (110) to the patient, during a downtime (dt) in which the treatment by NO is interrupted temporarily, in response to an actuation, by the user, of the means for stopping treatment.

2. Device according to Claim 1, characterized in that the control means are configured to control the graphic display to display the NO dose to be administered, before and during the treatment by NO and during the downtime (dt) in which the treatment by NO is interrupted temporarily.

3. Device according to one of the preceding claims, characterized in that the control means are additionally configured to control the valve means in order to supply a gaseous flowrate corresponding to the NO dose to be administered during the treatment by NO, in response to the actuation, by the user, of the means for starting treatment.

4. Device according to one of the preceding claims, characterized in that the control means are additionally configured to control the valve means in order to temporarily interrupt all gaseous flow during the downtime (dt), in response to the actuation, by the user, of the means for stopping treatment.

5. Device according to one of the preceding claims, characterized in that the means (120) for starting treatment and the means for stopping treatment comprise one and the same actuation element, which is actuatable by the user.

6. Device according to one of Claims 1 to 4, characterized in that the means (120) for starting treatment and the means for stopping treatment comprise separate actuation elements, which are actuatable by the user.

7. Device according to either of Claims 5 and 6, characterized in that the one or more actuation elements comprise one or more virtual keys displayed on the graphic display (10).

8. Device according to any one of the preceding claims, characterized in that the control means are configured to control the graphic display (10) to continue to display, during the downtime (dt), the NO dose having been administered (110) to the patient just before actuation, by the user, of the means for stopping treatment, that is to say before a pause.

9. Device according to Claim 8, characterized in that the memory storage means are configured to store the last dose of NO administered to the patient immediately before the commencement of the downtime (dt).

10. Device according to one of the preceding claims, characterized in that the downtime (dt) has a duration of less than or equal to 30 minutes.

11. Device according to Claim 7, characterized in that the one or more virtual keys displayed on the graphic display (10) are touch-sensitive keys.

12. Device according to either of Claims 1 and 11, characterized in that the graphic display (10) is a touch panel.

13. Installation (100) for administering therapeutic gas containing NO to a patient (P), comprising an NO supply device (1) according to one of the preceding claims, supplied with NO / N2 mixture by at least one pressurized gas container (5) and with oxygen by a pressurized oxygen container (52), said NO supply device (1) supplying an NO / N2 mixture to a respiratory gas circuit (3) connected to a medical ventilator (2) supplying an O2 / N2 mixture or air.

14. Installation according to Claim 13, characterized in that said at least one pressurized gas container (5) contains an NO / N2 mixture containing from 100 to 1000 ppmv of NO, the remainder being nitrogen.

15. Installation according to Claim 13, characterized in that the respiratory gas circuit (3) comprises a flowrate sensor.