Farnesoid x receptor agonists and uses thereof

Abstract

Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

Description

CROSS-REFERENCE

[0001] This application claims benefit of U.S. Provisional Application No. 62 / 733,004, filed on September 18, 2018, U.S. Provisional Application No. 62 / 733,006, filed on September 18, 2018, and U.S. Provisional Application No. 62 / 881,560, filed on August 1, 2019, all of which are herein incorporated by reference in their entirety.FIELD OF THE INVENTION

[0002] Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.BACKGROUND OF THE INVENTION

[0003] Farnesoid X receptor (FXR) is a nuclear receptor highly expressed in the liver, intestine, kidney, adrenal glands, and adipose tissue. FXR regulates a wide variety of target genes involved in the control of bile acid synthesis and transport, lipid metabolism, and glucose homeostasis. FXR agonism is a treatment modality for many metabolic disorders, liver diseases or conditions, inflammatory conditions, gastrointestinal diseases, or cell proliferation diseases.SUMMARY OF THE INVENTION

[0004] In one aspect, described herein is a compound of Formula (I'), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, pyrazolyl, furanyl, thienyl, pyrrolyl, imidazolyl, triazolyl, tetrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, or thiadiazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, or triazinyl; X 1< , X 5< , X 6< , and X 7< are each independently CR 7< or N; wherein at least one of X 1< , X 5< , X 6< , and X 7< are CR 7< ; R 1< is selected from H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), - S(=O) 2 N(R 17< ) 2 , -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< )2, -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , - NR 15< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, and monocyclic C 2 -C 5 heterocycloalkyl; X 2< is CR 2< or N; R 2< is H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< )2, - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< )2, -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , -NR 17< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, or monocyclic C 2 -C 5 heterocycloalkyl; or R 1< and R 2< are taken together with the intervening atoms to form a fused 5- or 6-membered ring with 0-3 N atoms and 0-2 O or S atoms in the ring, wherein the fused 5- or 6-membered ring is optionally substituted with halogen or C 1 -C 4 alkyl; X 3< is CR 3< or N; R 3< is H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< )2, -NR 17< C(=O)(C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl; each X 4< is independently CH, CF, or N; R 4< is H, F, or -CH 3 ; R 5< is H, F, or -CH 3 ; or R 4< and R 5< are taken together to form a bridge that is -CH 2 - or -CH 2 CH 2 -; each R 6< is independently H, F, -OH, or -CH 3 ; L is absent, -Y 2< -L 1< -, -L 1< -Y 2< -, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y 2< is absent, -O-, -S-, -S(=O)-, -S(=O) 2 -, -S(=O) 2 NR 17< -, -CH 2 -, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR 17< -, -NR 17< C(=O)-, - OC(=O)NR 17< -, -NR 17< C(=O)O-, -NR 17< C(=O)NR 17< -, -NR 17< S(=O) 2 -, or -NR 17< -; L 1< is absent or C 1 -C 4 alkylene; each R 7< is independently selected from H, halogen, -CN, -OH, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 3 -C 6 cycloalkyl, and C 1 -C 4 heteroalkyl; R 8< is C 4 -C 8 alkyl or C 4 -C 8 haloalkyl; R 9< is H, F, or -CH 3 ; R 10< is -OC(=O)N(R 12< )(R 13< ), -N(R 16< )C(=O)R 14< , or -N(R 16< )C(=O)OR 15< ; R 11< is H, F, or -CH 3 ; R 12< is -C 1 -C 6 alkyl-OR 17< or monocyclic C 2 -C 5 heterocycloalkyl optionally substituted with one or two oxo groups; R 13< is H or C 1 -C 4 alkyl; or R 12< and R 13< are taken together to form a 4-, 5-, or 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -S(C 1 -C 4 alkyl), - S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), -C 1 -C 4 alkyl-S(=O) 2 (C 1 -C 4 alkyl), -C 1 -C 6 alkyl-OR 17< , and -O-C 1 -C 6 alkyl-OR 17< ; R 14< is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or -C 1 -C 6 alkyl-OR 17< ; R 15< is C 1 -C 6 alkyl, -C 1 -C 6 alkyl-OR 17< , C 3 -C 6 cycloalkyl, or C 2 -C 6 heterocycloalkyl; R 16< is H or C 1 -C 6 alkyl; each R 17< is independently H or C 1 -C 6 alkyl; each R 18< is independently halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), - S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - C(=O)(C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), - NR 17< C(=O)(C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)O(C 1 -C 4 alkyl), - OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, monocyclic C 2 -C 6 heterocycloalkyl, phenyl, or monocyclic heteroaryl; m is 0, 1, or 2; and n is 0, 1, or 2.

[0005] In some embodiments is a compound of Formula (I'), or a pharmaceutically acceptable salt or solvate thereof, having the structure of Formula (Ia'):

[0006] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< is N, and X 5< , X 6< , and X 7< are CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< and X 6< are N, and X 5< and X 7< are CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< and X 7< are N, and X 5< and X 6< are CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< , X 5< , X 6< , and X 7< are CH.

[0007] In another aspect, described herein is a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, pyrazolyl, furanyl, thienyl, pyrrolyl, imidazolyl, triazolyl, tetrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, or thiadiazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, or triazinyl; X 1< is C(H), C(F), or N; R 1< is selected from H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), - S(=O) 2 N(R 17< ) 2 , -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< )2, -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , - NR 15< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, and monocyclic C 2 -C 5 heterocycloalkyl; X 2< is CR 2< or N; R 2< is H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , -NR 17< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl; or R 1< and R 2< are taken together with the intervening atoms to form a fused 5- or 6-membered ring with 0-3 N atoms and 0-2 O or S atoms in the ring, wherein the fused 5- or 6-membered ring is optionally substituted with halogen or C 1 -C 4 alkyl; X 3< is CR 3< or N; R 3< is H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl; each X 4< is independently CH or N; R 4< is H, F, or -CH 3 ; R 5< is H, F, or -CH 3 ; or R 4< and R 5< are taken together to form a bridge that is -CH 2 - or -CH 2 CH 2 -; each R 6< is independently H, F, -OH, or -CH 3 ; L is absent, -Y 2< -L 1< -, -L 1< -Y 2< -, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y 2< is absent, -O-, -S-, -S(=O)-, -S(=O) 2 -, -S(=O) 2 NR 17< -, -CH 2 -, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR 17< -, -NR 17< C(=O)-, - OC(=O)NR 17< -, -NR 17< C(=O)O-, -NR 17< C(=O)NR 17< -, -NR 17< S(=O) 2 -, or -NR 17< -; L 1< is absent or C 1 -C 4 alkylene; each R 7< is independently selected from H, halogen, -CN, -OH, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, and C 1 -C 4 heteroalkyl; R 8< is C 4 -C 8 alkyl or C 4 -C 8 haloalkyl; R 9< is H, F, or -CH 3 ; R 10< is -OC(=O)N(R 12< )(R 13< ), -N(R 16< )C(=O)R 14< , or -N(R 16< )C(=O)OR 15< ; R 11< is H, F, or -CH 3 ; R 12< is -C 1 -C 6 alkyl-OR 17< or monocyclic C 2 -C 5 heterocycloalkyl optionally substituted with one or two oxo groups; R 13< is H or C 1 -C 4 alkyl; or R 12< and R 13< are taken together to form a 4-, 5-, or 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -S(C 1 -C 4 alkyl), - S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), -C 1 -C 4 alkyl-S(=O) 2 (C 1 -C 4 alkyl), -C 1 -C 6 alkyl-OR 17< , and -O-C 1 -C 6 alkyl-OR 17< ; R 14< is C 1 -C 6 alkyl or -C 1 -C 6 alkyl-OR 17< ; R 15< is C 1 -C 6 alkyl, -C 1 -C 6 alkyl-OR 17< , or C 2 -C 6 heterocycloalkyl; R 16< is H or C 1 -C 6 alkyl; each R 17< is independently H or C 1 -C 6 alkyl; each R 18< is independently halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), - S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - C(=O)(C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), - NR 17< C(=O)(C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)O(C 1 -C 4 alkyl), - OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, monocyclic C 2 -C 6 heterocycloalkyl, phenyl, or monocyclic heteroaryl; m is 0, 1, or 2; and n is 0, 1, or 2.

[0008] In some embodiments is a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, having the structure of Formula (Ia):

[0009] In some embodiments is a compound of Formula (I'), (I), (Ia'), or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, imidazolyl, or pyrazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl or pyrimidinyl. In some embodiments is a compound of Formula (I'), (I), (Ia'), or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring n is 0. In some embodiments is a compound of Formula (I'), (I), (Ia'), or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring In some embodiments is a compound of Formula (I'), (I), (Ia'), or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -OC(=O)N(R 12< )(R 13< ). In some embodiments is a compound of Formula (I'), (I), (Ia'), or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< is -C 1 -C 6 alkyl-OR 17< . In some embodiments is a compound of Formula (I'), (I), (Ia'), or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< is - CH 2 CH 2 OH, -CH 2 CH 2 CH 2 OH, or -CH 2 CH 2 C(CH 3 ) 2 OH. In some embodiments is a compound of Formula (I'), (I), (Ia'), or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 13< is H. In some embodiments is a compound of Formula (I'), (I), (Ia'), or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 4-, 5-, or 6- membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -S(=O) 2 (C 1 -C 4 alkyl), - C 1 -C 4 alkyl-S(=O) 2 (C 1 -C 4 alkyl), -C 1 -C 6 alkyl-OR 17< , and -O-C 1 -C 6 alkyl-OR 17< .

[0010] In another aspect, described herein is a compound of Formula (II), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is X 1< is CH or N; R 1< is H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , -NR 15< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl; X 2< is CR 2< or N; R 2< is H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , -NR 17< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl; or R 1< and R 2< are taken together with the intervening atoms to form a fused 5- or 6-membered ring with 0-3 N atoms and 0-2 O or S atoms in the ring, wherein the fused 5- or 6-membered ring is optionally substituted with halogen or C 1 -C 4 alkyl; X 3< is CR 3< or N; R 3< is H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl; each X 4< is independently CH or N; R 4< is H, F, or -CH 3 ; R 5< is H, F, or -CH 3 ; or R 4< and R 5< are taken together to form a bridge that is -CH 2 - or -CH 2 CH 2 -; each R 6< is independently H, F, -OH, or -CH 3 ; R 7< is H, halogen, -CN, -OH, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl; L is absent, -Y 2< -L 1< -, -L 1< -Y 2< -, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y 2< is absent, -O-, -S-, -S(=O)-, -S(=O) 2 -, -S(=O) 2 NR 17< -, -CH 2 -, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR 17< -, -NR 17< C(=O)-, - OC(=O)NR 17< -, -NR 17< C(=O)O-, -NR 17< C(=O)NR 17< -, -NR 17< S(=O) 2 -, or -NR 17< -; L 1< is absent or C 1 -C 4 alkylene; R 8< is C 4 -C 8 alkyl; R 9< is H, F, or -CH 3 ; R 10< is -OC(=O)N(R 12< )(R 13< ), -N(R 16< )C(=O)R 14< , or -N(R 16< )C(=O)OR 15< ; R 11< is H, F, or -CH 3 ; R 12< and R 13< are taken together to form a 4-, 5-, or 6- membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy; R 14< is C 1 -C 6 alkyl or -C 1 -C 6 alkyl-OR 17< ; R 15< is C 1 -C 6 alkyl, -C 1 -C 6 alkyl-OR 17< , or C 2 -C 6 heterocycloalkyl; R 16< is H or C 1 -C 6 alkyl; each R 17< is independently H or C 1 -C 6 alkyl; and m is 0, 1, or 2.

[0011] In some embodiments is a compound of Formula (II), or a pharmaceutically acceptable salt or solvate thereof, having the structure of Formula (IIa):

[0012] In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 3 ) 3 . In some embodiments is a compound of Formula (I), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< is N. In some embodiments is a compound of Formula (I), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< is CH. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< is H and R 5< is H. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 - or -CH 2 CH 2 -. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 CH 2 -. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -OC(=O)N(R 12< )(R 13< ). In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 4-membered or 5-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -N(R 16< )C(=O)R 14< . In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is C 1 -C 6 alkyl. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OR 17< . In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -N(R 16< )C(=O)OR 15< . In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is C 1 -C 6 alkyl. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OR 17< . In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is C 2 -C 6 heterocycloalkyl. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 16< is H. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein one X 4< is CH and one X 4< is N. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein each X 4< is CH. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is CH. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< . In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 2< is halogen, -CN, or C 1 -C 4 alkyl. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 2< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl or C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -OCH 3 . In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein L is absent. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 9< is H. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 11< is H. In some embodiments is a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein each R 7< is H.

[0013] Any combination of the groups described above for the various variables is contemplated herein. Throughout the specification, groups and substituents thereof are chosen by one skilled in the field to provide stable moieties and compounds.

[0014] In one aspect, described herein is a pharmaceutical composition comprising a compound described herein, or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable excipient. In some embodiments, the pharmaceutical composition is formulated for administration to a mammal by intravenous administration, subcutaneous administration, oral administration, inhalation, nasal administration, dermal administration, or ophthalmic administration. In some embodiments, the pharmaceutical composition is formulated for administration to a mammal by intravenous administration, subcutaneous administration, or oral administration. In some embodiments, the pharmaceutical composition is formulated for administration to a mammal by oral administration. In some embodiments, the pharmaceutical composition is in the form of a tablet, a pill, a capsule, a liquid, a suspension, a gel, a dispersion, a solution, an emulsion, an ointment, or a lotion. In some embodiments, the pharmaceutical composition is in the form of a tablet, a pill, or a capsule.

[0015] In another aspect, described herein is a method of treating a disease or condition in a mammal that would benefit from FXR agonism comprising administering a compound as described herein, or pharmaceutically acceptable salt or solvate thereof, to the mammal in need thereof. In some embodiments, the disease or condition is a metabolic condition. In some embodiments, the disease or condition is a liver condition.

[0016] In some embodiments, the compound is administered to the mammal by intravenous administration, subcutaneous administration, oral administration, inhalation, nasal administration, dermal administration, or ophthalmic administration.

[0017] In one aspect, described herein is a method of treating or preventing any one of the diseases or conditions described herein comprising administering a therapeutically effective amount of a compound described herein, or a pharmaceutically acceptable salt or solvate thereof, to a mammal in need thereof.

[0018] In one aspect, described herein is a method for the treatment or prevention of a metabolic or liver condition in a mammal comprising administering a therapeutically effective amount of a compound described herein, or a pharmaceutically acceptable salt or solvate thereof, to the mammal in need thereof. In other embodiments, the metabolic or liver condition is amenable to treatment with an FXR agonist. In some embodiments, the method further comprises administering a second therapeutic agent to the mammal in addition to the compound described herein, or a pharmaceutically acceptable salt or solvate thereof.

[0019] In one aspect, described herein is a method of treating or preventing a liver disease or condition in a mammal, comprising administering to the mammal a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof. In some embodiments, the liver disease or condition is an alcoholic or non-alcoholic liver disease. In some embodiments, the liver disease or condition is primary biliary cirrhosis, primary sclerosing cholangitis, cholestasis, nonalcoholic steatohepatitis (NASH), or nonalcoholic fatty liver disease (NAFLD). In some embodiments, the alcoholic liver disease or condition is fatty liver (steatosis), cirrhosis, or alcoholic hepatitis. In some embodiments, the non-alcoholic liver disease or condition is nonalcoholic steatohepatitis (NASH), or nonalcoholic fatty liver disease (NAFLD). In some embodiments, the non-alcoholic liver disease or condition is nonalcoholic steatohepatitis (NASH). In some embodiments, the non-alcoholic liver disease or condition is nonalcoholic steatohepatitis (NASH) and is accompanied by liver fibrosis. In some embodiments, the non-alcoholic liver disease or condition is nonalcoholic steatohepatitis (NASH) without liver fibrosis. In some embodiments, the non-alcoholic liver disease or condition is intrahepatic cholestasis or extrahepatic cholestasis.

[0020] In one aspect, described herein is a method of treating or preventing a liver fibrosis in a mammal, comprising administering to the mammal a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof. In some embodiments, the mammal is diagnosed with hepatitis C virus (HCV), nonalcoholic steatohepatitis (NASH), primary sclerosing cholangitis (PSC), cirrhosis, Wilson's disease, hepatitis B virus (HBV), HIV associated steatohepatitis and cirrhosis, chronic viral hepatitis, non-alcoholic fatty liver disease (NAFLD), alcoholic steatohepatitis (ASH), nonalcoholic steatohepatitis (NASH), primary biliary cirrhosis (PBC), or biliary cirrhosis. In some embodiments, the mammal is diagnosed with nonalcoholic steatohepatitis (NASH).

[0021] In one aspect, described herein is a method of treating or preventing a liver inflammation in a mammal, comprising administering to the mammal a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof. In some embodiments, the mammal is diagnosed with hepatitis C virus (HCV), nonalcoholic steatohepatitis (NASH), primary sclerosing cholangitis (PSC), cirrhosis, Wilson's disease, hepatitis B virus (HBV), HIV associated steatohepatitis and cirrhosis, chronic viral hepatitis, non-alcoholic fatty liver disease (NAFLD), alcoholic steatohepatitis (ASH), nonalcoholic steatohepatitis (NASH), primary biliary cirrhosis (PBC), or biliary cirrhosis. In some embodiments, the mammal is diagnosed with nonalcoholic steatohepatitis (NASH). In some embodiments, the liver inflammation is associated with inflammation in the gastrointestinal tract. In some embodiments, the mammal is diagnosed with inflammatory bowel disease.

[0022] In one aspect, described herein is a method of treating or preventing a gastrointestinal disease or condition in a mammal, comprising administering to the mammal a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof. In some embodiments, the gastrointestinal disease or condition is necrotizing enterocolitis, gastritis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, irritable bowel syndrome, gastroenteritis, radiation induced enteritis, pseudomembranous colitis, chemotherapy induced enteritis, gastro-esophageal reflux disease (GERD), peptic ulcer, non-ulcer dyspepsia (NUD), celiac disease, intestinal celiac disease, post-surgical inflammation, gastric carcinogenesis, graft versus host disease, or any combination thereof. In some embodiments, the gastrointestinal disease is irritable bowel syndrome (IBS), irritable bowel syndrome with diarrhea (IBS-D), irritable bowel syndrome with constipation (IBS-C), mixed IBS (IBS-M), unsubtyped IBS (IBS-U), or bile acid diarrhea (BAD).

[0023] In one aspect, described herein is a method of treating or preventing a disease or condition in a mammal that would benefit from treatment with an FXR agonist, comprising administering to the mammal a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof. In some embodiments, the methods described herein further comprise administering at least one additional therapeutic agent in addition to the compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa), or a pharmaceutically acceptable salt or solvate thereof.

[0024] In any of the aforementioned aspects are further embodiments in which the effective amount of the compound described herein, or a pharmaceutically acceptable salt thereof, is: (a) systemically administered to the mammal; and / or (b) administered orally to the mammal; and / or (c) intravenously administered to the mammal; and / or (d) administered by inhalation; and / or (e) administered by nasal administration; or and / or (f) administered by injection to the mammal; and / or (g) administered topically to the mammal; and / or (h) administered by ophthalmic administration; and / or (i) administered rectally to the mammal; and / or (j) administered non-systemically or locally to the mammal.

[0025] In any of the aforementioned aspects are further embodiments comprising single administrations of the effective amount of the compound, including further embodiments in which the compound is administered once a day to the mammal or the compound is administered to the mammal multiple times over the span of one day. In some embodiments, the compound is administered on a continuous dosing schedule. In some embodiments, the compound is administered on a continuous daily dosing schedule.

[0026] In any of the aforementioned aspects involving the treatment of a disease or condition are further embodiments comprising administering at least one additional agent in addition to the administration of a compound of Formula (I'), (I), (Ia'), (Ia), (II), or (IIa) described herein, or a pharmaceutically acceptable salt thereof. In various embodiments, each agent is administered in any order, including simultaneously.

[0027] In any of the embodiments disclosed herein, the mammal or subject is a human.

[0028] In some embodiments, compounds provided herein are administered to a human.

[0029] In some embodiments, compounds provided herein are orally administered.

[0030] In some embodiments, described herein is a method of treating or preventing a metabolic disorder in a subject, comprising: administering to a gastrointestinal tract of the subject a therapeutically effective amount of one or more of the compounds described herein, or a pharmaceutically acceptable salt or solvate thereof, thereby activating farnesoid X receptors (FXR) in the intestines, and treating or preventing a metabolic disorder in the subject. In some embodiments, the compound's absorption is preferentially restricted to within the intestines. In some embodiments, the method substantially enhances FXR target gene expression in the intestines while not substantially enhancing FXR target gene expression in the liver or kidney. In some embodiments, the method substantially enhances FXR target gene expression in the intestines while minimizing systemic plasma levels of the delivered compound. In some embodiments, the method substantially enhances FXR target gene expression in the intestines and the liver while minimizing systemic plasma levels of the delivered compound. In some embodiments, the method substantially enhances FXR target gene expression in the intestines while not substantially enhancing FXR target gene expression in the liver or kidney, and while minimizing systemic plasma levels. In some embodiments, the method substantially enhances FXR target gene expression in the intestines and the liver and provides sustained systemic plasma levels of the delivered compound. In some embodiments, the method reduces or prevents diet-induced weight gain. In some embodiments, the method increases a metabolic rate in the subject. In some embodiments, the increasing the metabolic rate comprises enhancing oxidative phosphorylation in the subject. In some embodiments, the method further comprises improving glucose and / or lipid homeostasis in the subject. In some embodiments, the method results in no substantial change in food intake and / or fat consumption in the subject. In some embodiments, the method results in no substantial change in appetite in the subject. In some embodiments, the metabolic disorder is selected from obesity, diabetes, insulin resistance, dyslipidemia or any combination thereof. In some embodiments, the metabolic disorder is non-insulin dependent diabetes mellitus. In some embodiments, the method protects against diet-induced weight gain, reduces inflammation, enhances thermogenesis, enhances insulin sensitivity in the liver, reduces hepatic steatosis, promotes activation of BAT, decreases blood glucose, increases weight loss, or any combination thereof. In some embodiments, the method enhances insulin sensitivity in the liver and promotes brown adipose tissue (BAT) activation. In some embodiments, the method further comprises administering to the subject an insulin sensitizing drug, an insulin secretagogue, an alpha-glucosidase inhibitor, a glucagon-like peptide (GLP) agonist, a dipeptidyl peptidase-4 (DPP-4) inhibitor, nicotinamide ribonucleoside, an analog of nicotinamide ribonucleoside, or combinations thereof.

[0031] In some embodiments, described herein is a method of treating or preventing inflammation in an intestinal region of a subject, comprising: administering to a gastrointestinal tract of the subject a therapeutically effective amount of one or more of the compounds described herein, or a pharmaceutically acceptable salt or solvate thereof, thereby activating FXR receptors in the intestines, and thereby treating or preventing inflammation in the intestinal region of the subject. In some embodiments, the compound's absorption is preferentially restricted to within the intestines. In some embodiments, the method substantially enhances FXR target gene expression in the intestines while not substantially enhancing FXR target gene expression in the liver or kidney. In some embodiments, the inflammation is associated with a clinical condition selected from necrotizing enterocolitis, gastritis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, irritable bowel syndrome, gastroenteritis, radiation induced enteritis, pseudomembranous colitis, chemotherapy induced enteritis, gastro-esophageal reflux disease (GERD), peptic ulcer, non-ulcer dyspepsia (NUD), celiac disease, intestinal celiac disease, post-surgical inflammation, gastric carcinogenesis or any combination thereof. In some embodiments, the one or more FXR target genes comprises IBABP, OSTα, Per1, FGF15, FGF19, SHP or combinations thereof. In some embodiments, the method further comprises administering a therapeutically effective amount of an antibiotic therapy to the subject, wherein the method treats or prevents inflammation associated with pseudomembranous colitis in the subject. In some embodiments, the method further comprises administering to the subject a therapeutically effective amount of an oral corticosteroid, other anti-inflammatory or immunomodulatory therapy, nicotinamide ribonucleoside, an analog of nicotinamide ribonucleoside, or combinations thereof. In some embodiments, the method increases HSL phosphorylation and β3-adrenergic receptor expression. In some embodiments, a serum concentration of the compound in the subject remains below its EC 50 following administration of the compound.

[0032] In some embodiments, described herein is a method of treating or preventing a cell proliferation disease in a subject, comprising administering to a gastrointestinal tract of the subject a therapeutically effective amount of one or more of the compounds described herein or a pharmaceutically acceptable salt or solvate thereof. In some embodiments, the cell proliferation disease is an adenocarcinoma. In some embodiments, the adenocarcinoma is a colon cancer. In some embodiments, the treating the adenocarcinoma reduces the size of the adenocarcinoma, the volume of the adenocarcinoma, the number of adenocarcinomas, cachexia due to the adenocarcinoma, delays progression of the adenocarcinoma, increases survival of the subject, or combinations thereof. In some embodiments, the method further comprises administering to the subject an additional therapeutic compound selected from the group consisting of a chemotherapeutic, a biologic, a radiotherapeutic, or combinations thereof.

[0033] In some embodiments, described herein is a method of treating or preventing a liver disease or condition in a subject, comprising administering to the subject a therapeutically effective amount of one or more of the compounds described herein, or a pharmaceutically acceptable salt or solvate thereof. In some embodiments, the liver disease or condition is an alcoholic or non-alcoholic liver disease. In some embodiments, the liver disease or condition is primary biliary cirrhosis, primary sclerosing cholangitis, cholestasis, nonalcoholic steatohepatitis (NASH), or nonalcoholic fatty liver disease (NAFLD). In some embodiments, the alcoholic liver disease or condition is fatty liver (steatosis), cirrhosis, or alcoholic hepatitis. In some embodiments, the non-alcoholic liver disease or condition is nonalcoholic steatohepatitis (NASH), or nonalcoholic fatty liver disease (NAFLD). In some embodiments, the non-alcoholic liver disease or condition is intrahepatic cholestasis or extrahepatic cholestasis.

[0034] Articles of manufacture, which include packaging material, a compound described herein, or a pharmaceutically acceptable salt thereof, within the packaging material, and a label that indicates that the compound or composition, or pharmaceutically acceptable salt, pharmaceutically active metabolite, pharmaceutically acceptable prodrug, or pharmaceutically acceptable solvate thereof, is used for the treatment, prevention or amelioration of one or more symptoms of a disease or condition that would benefit from FXR agonism, are provided.

[0035] Other objects, features and advantages of the compounds, methods and compositions described herein will become apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples, while indicating specific embodiments, are given by way of illustration only, since various changes and modifications within the spirit and scope of the instant disclosure will become apparent to those skilled in the art from this detailed description.DETAILED DESCRIPTION OF THE INVENTION

[0036] The nuclear hormone receptor farnesoid X receptor (also known as FXR or nuclear receptor subfamily 1, group H, member 4 (NR1H4)) (OMIM: 603826) functions as a regulator for bile acid metabolism. FXR is a ligand-activated transcriptional receptor expressed in diverse tissues including the adrenal gland, kidney, stomach, duodenum, jejunum, ileum, colon, gall bladder, liver, macrophages, and white and brown adipose tissue. FXRs are highly expressed in tissues that participate in bile acid metabolism such as the liver, intestines, and kidneys. Bile acids function as endogenous ligands for FXR such that enteric and systemic release of bile acids induces FXR-directed changes in gene expression networks. Bile acids are the primary oxidation product of cholesterol, and in some cases, upon secretion into the intestines, are regulators of cholesterol absorption. The rate-limiting step for conversion of cholesterol into bile acids is catalyzed by cytochrome p450 enzyme cholesterol 7-α-hydroxylase (CYP7A1) and occurs in the liver. The cytochrome p450 enzyme sterol 12-α-hydroxylase (CYP8B 1) mediates production of cholic acid and determines the relative amounts of the two primary bile acids, cholic acid and chenodeoxycholic acid. Activation of FXR can represses the transcription of CYP7A1 and CYP8B1 by increasing the expression level of the hepatic small heterodimer partner (SHP) (also known as nuclear receptor subfamily 0, group B, member 2; or NR0B2) and intestinal expression of fibroblast growth factor 15 (FGF15) in mice and fibroblast growth factor 19 (FGF19) in human. SHP represses the liver receptor homolog (LRH-1) and hepatocyte nuclear factor 4 alpha (HNFa4), transcription factors that regulate CYP7A1 and CYP8B 1 gene expression. CYP8B 1 repression by FXR can be species-specific and FXR activation may in some cases increase CYP8B1 expression in humans (Sanyal et al PNAS, 2007, 104, 15665). In some cases, FGF15 / 19 released from the intestine then activates the fibroblast growth factor receptor 4 in the liver, leading to activation of the mitogen-activated protein kinase (MAPK) signaling pathway which suppress CYP7A1 and CYP8B 1.

[0037] In some embodiments, elevated levels of bile acids have been associated with insulin resistance. For example, insulin resistance sometimes leads to a decreased uptake of glucose from the blood and increased de novo glucose production in the liver. In some instances, intestinal sequestration of bile acids has been shown to improve insulin resistance by promoting the secretion of glucagon-like peptide-1 (GLP1) from intestinal L-cells. GLP-1 is an incretin derived from the transcription product of the proglucagon gene. It is released in response to the intake of food and exerts control in appetite and gastrointestinal function and promotes insulin secretion from the pancreas. The biologically active forms of GLP-1 include GLP-1-(7-37) and GLP-1-(7-36)NH 2 , which result from selective cleavage of the proglucagon molecule. In such cases, activation of FXR leading to decreased production of bile acids correlates to a decrease in insulin resistance.

[0038] In some embodiments, the activation of FXR also correlates to the secretion of pancreatic polypeptide-fold such as peptide YY (PYY or PYY3-36). In some instances, peptide YY is a gut hormone peptide that modulates neuronal activity within the hypothalamic and brainstem, regions of the brain involved in reward processing. In some instances, reduced level of PYY correlates to increased appetite and weight gain.

[0039] In some instances, the activation of FXR indirectly leads to a reduction of plasma triglycerides. The clearance of triglycerides from the bloodstream is due to lipoprotein lipase (LPL). LPL activity is enhanced by the induction of its activator apolipoprotein CII, and the repression of its inhibitor apolipoprotein CIII in the liver occurs upon FXR activation.

[0040] In some cases, the activation of FXR further modulates energy expenditure such as adipocyte differentiation and function. Adipose tissue comprises adipocytes or fat cells. In some instances, adipocytes are further differentiated into brown adipose tissue (BAT) or white adipose tissue (WAT). The function of BAT is to generate body heat, while WAT functions as fat storing tissues.

[0041] In some instances, FXR is widely expressed in the intestine. In some cases, the activation of FXR has been shown to induce the expression and secretion of FGF19 (or FGF15 in mouse) in the intestine. FGF19 is a hormone that regulates bile acid synthesis as well as exerts an effect on glucose metabolism, lipid metabolism, and on energy expenditure. In some instances, FGF19 has also been observed to modulate adipocyte function and differentiation. Indeed, a study has shown that the administration of FGF19 to high-fat diet-fed mice increased energy expenditure, modulated adipocytes differentiation and function, reversed weight gain, and improved insulin resistance (see, Fu et al., "Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes." Endocrinology 145:2594-2603 (2004)).

[0042] In some cases, intestinal FXR activity has also been shown to be involved in reducing overgrowth of the microbiome, such as during feeding (Li et al., Nat Commun 4:2384, 2013). For example, a study had shown that activation of FXR correlated with increased expression of several genes in the ileum such as Ang2, iNos, and Il18, which have established antimicrobial actions (Inagaki et al., Proc Natl Acad Sci U S A 103:3920-3925, 2006).

[0043] In some cases, FXR has been implicated in barrier function and immune modulation in the intestine. FXR modulates transcription of genes involved in bile salt synthesis, transport and metabolism in the liver and intestine, and in some cases has been shown to lead to improvements in intestinal inflammation and prevention of bacterial translocation into the intestinal tract (Gadaleta et al., Gut. 2011 Apr; 60(4):463-72).

[0044] In some cases, over production of bile acids or improper transport and re-cycling of bile acids can lead to diarrhea. FXR modulates transcription of genes involved in bile salt synthesis, transport and metabolism in the liver and intestine, and in some cases may lead to improvements in diarrhea Camilleri, Gut Liver. 2015 May; 9(3): 332-339.

[0045] G protein-coupled bile acid receptor 1 (also known as GPBAR2, GPCR19, membrane-type receptor for bile acids or M-BAR, or TGR5) is a cell surface receptor for bile acids. Upon activation with bile acid, TGR5 induces the production of intracellular cAMP, which then triggers an increase in triiodothyronine due to the activation of deiodinase (DIO2) in BAT, resulting in increased energy expenditure.

[0046] Hence in some embodiments, regulation of metabolic processes such as bile acid synthesis, bile-acid circulation, glucose metabolism, lipid metabolism, or insulin sensitivity is modulated by the activation of FXR. Furthermore, in some embodiments, dis-regulation of metabolic processes such as bile acid synthesis, bile-acid circulation, glucose metabolism, lipid metabolism, or insulin sensitivity results in metabolic diseases such as diabetes or diabetes-related conditions or disorders, alcoholic or non-alcoholic liver disease or condition, intestinal inflammation, or cell proliferative disorders.

[0047] Disclosed herein, in certain embodiments, are compounds that have activity as FXR agonists. In some embodiments, the FXR agonists described herein are structurally distinct from bile acids, other synthetic FXR ligands, and other natural FXR ligands.

[0048] In some embodiments, also disclosed herein are methods of treating or preventing a metabolic disorder, such as diabetes, obesity, impaired glucose tolerance, dyslipidemia, or insulin resistance by administering a therapeutically effective amount of an FXR agonist. In some instances, the compounds are administered to the GI tract of a subject.

[0049] In additional embodiments, disclosed herein are methods for treating or preventing alcoholic or non-alcoholic liver disease or conditions (e.g., cholestasis, primary biliary cirrhosis, steatosis, cirrhosis, alcoholic hepatitis, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), primary sclerosing cholangitis (PSC), or elevated liver enzymes) by administering a therapeutically effective amount of an FXR agonist to a subject in need thereof (e.g., via the GI tract). In additional embodiments, disclosed herein include methods for treating or preventing cholestasis, cirrhosis, primary biliary cirrhosis, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), or primary sclerosing cholangitis (PSC) by administering a therapeutically effective amount of an FXR agonist to a subject in need thereof. In some embodiments, disclosed herein include methods for treating or preventing cholestasis by administering a therapeutically effective amount of an FXR agonist to a subject in need thereof. In some embodiments, disclosed herein include methods for treating or preventing primary biliary cirrhosis by administering a therapeutically effective amount of an FXR agonist to a subject in need thereof. In some embodiments, disclosed herein include methods for treating or preventing NASH by administering a therapeutically effective amount of an FXR agonist to a subject in need thereof. In some embodiments, disclosed herein include methods for treating or preventing NAFLD by administering a therapeutically effective amount of an FXR agonist to a subject in need thereof.

[0050] In further embodiments, disclosed herein include methods for treating or preventing inflammation in the intestines and / or a cell proliferative disorder, such as cancer, by administering a therapeutically effective amount of an FXR agonist to a subject in need thereof (e.g., via the GI tract).

[0051] In still further embodiments, disclosed herein include FXR agonists that modulate one or more of the proteins or genes associated with a metabolic process such as bile acid synthesis, glucose metabolism, lipid metabolism, or insulin sensitivity, such as for example, increase in the activity of FGF 19 (FGF15 in mouse), increase in the secretion of GLP-1, or increase in the secretion of PYY.Metabolic Disorders

[0052] Disclosed herein, in certain embodiments, are methods of treating a metabolic disorder in a subject in need thereof. Also described herein include methods of preventing a metabolic disorder in a subject in need thereof. In some instances, these methods include administering to the subject in need thereof a therapeutically effective amount of one or more of the compounds disclosed herein. In some instances, the one or more compounds disclosed herein are absorbed in the gastrointestinal (GI) tract. In additional instances, the one or more disclosed compounds absorbed in the GI tract activates FXR receptors thereby treating or preventing a metabolic disorder in the subject.

[0053] In some embodiments, the disclosed compounds demonstrate systemic exposure. In some instances, the disclosed compounds have local exposure in the intestines, but limited exposure in the liver or systemically. In some embodiments, local exposure of the disclosed compounds in the intestines maybe demonstrated by regulation of FXR target genes in the intestines. In some embodiments, the target genes may include: SHP, FGF19 (FGF15), IBABP, C3, OST α / β. In some embodiments, exposure of the disclosed compounds is about 40%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99%, 99.5%, or more in the intestines. In some instances, exposure of the disclosed compounds is about 0.5%, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, or less in the systemic circulation. In some embodiments, the exposure of the FXR agonists in the intestinal lumen reduces the chance of side effects which results from systemic action, thereby improving the safety profile of the therapy. In additional embodiments, the disclosed compounds enhance FXR target gene expression in the intestines. In additional embodiments, the disclosed compounds further modulate gene expressions in the FXR-mediated pathway, such as for example, FGF19 (FGF15) which inhibits CYP7A1 and CYP8B1 gene expression in the liver. In some instances, the disclosed compounds enhance gene expression in the FXR-mediated pathway. In other instances, the disclosed compounds reduce or inhibit gene expression in the FXR-mediated pathway. In some instances, enhancing is about 1%, 5%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 200%, 300%, 500%, 1,000%, 5,000%, 10,000%, 50,000%, 100,000%, 500,000%, or higher in gene expression in the intestines, liver, kidney, or other tissues relative to the gene expression in the absence of the disclosed compound. In some cases, reducing is about 100%, 90%, 80%, 70%, 60%, 50%, 40%, 30%, 25%, 20%, 15%, 10%, 5%, 1%, or less in gene expression in the intestines, liver, kidney, or other tissues relative to the gene expression in the absence of the disclosed compound.

[0054] In some embodiments, the method substantially enhances FXR target gene expression in the intestines while minimizing systemic plasma levels of the delivered compound. In some embodiments, the method substantially enhances FXR target gene expression in the intestines and the liver while minimizing systemic plasma levels of the delivered compound. In some embodiments, the method substantially enhances FXR target gene expression in the intestines while not substantially enhancing FXR target gene expression in the liver or kidney, and while minimizing systemic plasma levels. In some embodiments, the method substantially enhances FXR target gene expression in the intestines and the liver and provides sustained systemic plasma levels of the delivered compound.

[0055] In some embodiments, metabolic disorder refers to any disorder that involves an alteration in the normal metabolism of carbohydrates, lipids, proteins, nucleic acids or a combination thereof. In some instances, a metabolic disorder is associated with either a deficiency or excess in a metabolic pathway resulting in an imbalance in metabolism of nucleic acids, proteins, lipids, and / or carbohydrates. Factors affecting metabolism include, but are not limited to, the endocrine (hormonal) control system (e.g., the insulin pathway, the enteroendocrine hormones including GLP-1, oxyntomodulin, PYY or the like), or the neural control system (e.g., GLP-1 in the brain). Exemplary metabolic disorders include, but are not limited to, diabetes, insulin resistance, dyslipidemia, liver disease, inflammation related intestinal conditions, cell proliferative disorders, or the like.Diabetes Mellitus and Diabetes-related Conditions or Disorders

[0056] In some embodiments, disclosed herein are methods of treating a subject having diabetes mellitus or diabetes-related condition or disorder with administration of an FXR agonist described herein. In some instances, diabetes is type II diabetes or non-insulin-dependent diabetes mellitus (NIDDM). In some instances, diabetes-related conditions or disorders include obesity, impaired glucose tolerance, dyslipidemia, and insulin resistance. In some instances, diabetes-related conditions or disorders further include secondary complications such as atherosclerosis, stroke, fatty liver disease, blindness, gallbladder disease, or polycystic ovary disease. In some cases, an FXR agonist is administered for the treatment of type II diabetes, obesity, impaired glucose tolerance, dyslipidemia, insulin resistance, or secondary complications such as atherosclerosis, stroke, fatty liver disease, blindness, gallbladder disease, or polycystic ovary disease.

[0057] In some embodiments, a diabetic subject (e.g., a type II diabetic subject) is further characterized with a body mass index (BMI) of 25 or greater, 30 or greater, 35 or greater, 40 or greater, such as a BMI of 25 to 29, 30 to 34, or 35 to 40.

[0058] In some examples, an FXR agonist described herein reduces or prevents weight gain in a subject. In some instances, the weight gain is diet-induced weight gain. In other instances, the weight gain is non-diet-related, such as familial / genetic obesity or obesity resulting from medication. In some examples, such methods reduce or prevent weight gain in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, weight gain is reduced or prevented by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some cases, the reduction or prevention of weight gain is relative to the reduction or prevention of weight gain observed in a subject not treated with the FXR agonist.

[0059] Similarly, in some cases, the FXR agonist reduces the BMI of a subject. In some examples, such methods reduce the BMI of a subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 25%, at least 30%, or more, relative to a subject not treated with the FXR agonist. In some instances, the subject is overweight but not obese. In other instances, the subject is neither overweight nor obese.

[0060] In some instances, administration of an FXR agonist results in a decrease in the amount of serum lipids. In some examples, the decrease in the amount of serum lipids is by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 50%, at least 60%, at least 70%, at least 75%, or more. In some cases, the decrease in the amount of serum lipids is by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, by about 10% to about 70%, or by about 10% to about 30%. In some cases, the decrease in the amount of serum lipids is relative to the amount of serum lipids observed in a subject not treated with the FXR agonist.

[0061] In some examples, administration of an FXR agonist results in a decrease in triglyceride (e.g., hepatic triglyceride) level. In some instances, the decrease in triglyceride (e.g., hepatic triglyceride) level is by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 50%, at least 60%, at least 70%, at least 75%, or more. In some instances, the decrease in triglyceride (e.g., hepatic triglyceride) level is by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, by about 10% to about 70%, or by about 10% to about 30%. In some cases, the decrease in triglyceride (e.g., hepatic triglyceride) level is relative to the triglyceride (e.g., hepatic triglyceride) level observed in a subject not treated with the FXR agonist.

[0062] In some examples, administration of an FXR agonist results in an increased insulin sensitivity to insulin in the liver. In some instances, the increase in insulin sensitivity is by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some cases, the increase in insulin sensitivity is by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some cases, the increase in insulin sensitivity is relative to sensitivity observed in a subject not treated with the FXR agonist.

[0063] In some embodiments, administration of an FXR agonist results in a decrease in the amount of serum insulin in the subject. In some examples, the decrease in serum insulin is by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 50%, at least 60%, at least 70%, at least 75%, or more. In some instances, serum insulin is decreased by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, by about 10% to about 70%, or by about 10% to about 30%. In some cases, the decrease in serum insulin level is relative to levels observed in a subject not treated with the FXR agonist.

[0064] In some embodiments, administration of an FXR agonist results in a decrease in the amount of serum glucose in the subject. In some examples, the decrease in serum glucose is by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 50%, at least 60%, at least 70%, at least 75%, or more. In some instances, serum glucose is decreased by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, by about 10% to about 70%, or by about 10% to about 30%. In some cases, the decrease in serum glucose level is relative to levels observed in a subject not treated with the FXR agonist.

[0065] In some examples, an FXR agonist described herein increases browning of white adipose tissue in a subject. In some examples, the rate of increase of browning of white adipose tissue in the subject is by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more, relative to a subject not treated with the FXR agonist.

[0066] In some embodiments, administration of an FXR agonist does not result in substantial change in food intake and / or fat consumption in the subject. In some instances, food intake and / or fat consumption is reduced, such as by less than 15%, less than 10%, or less than 5%. In some embodiments, no substantial change in appetite in the subject results. In other embodiments, reduction in appetite is minimal as reported by the subject.

[0067] In some embodiments, administration of an FXR agonist results in an increase in the metabolic rate in the subject. In some instances, the FXR agonist increases the metabolic rate in a subject. In some cases, the metabolic rate in the subject is increased by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 75%, or more. In some instances, the metabolic rate is increased by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, by about 10% to about 70%, or by about 10% to about 30%. In some cases, the increase in metabolic rate is relative to the rate observed in a subject not treated with the FXR agonist.

[0068] In some embodiments, the increase in metabolism results from enhanced oxidative phosphorylation in the subject, which in turn leads to increased energy expenditure in tissues (such as BAT). In such instances, the FXR agonist helps to increase the activity of BAT. In some examples, the activity of BAT is increased by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 50%, at least 60%, at least 70%, at least 75%, or more. In some instances, the activity of BAT is increased by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, by about 10% to about 70%, or by about 10% to about 30%. In some cases, the increase in BAT activity is relative to the activity of BAT observed in a subject not treated with the FXR agonist.Alcoholic and Non-Alcoholic Liver Disease or Condition

[0069] Disclosed herein include methods of preventing and / or treating alcoholic or non-alcoholic liver diseases or conditions. Exemplary alcoholic or non-alcoholic liver diseases or conditions include, but are not limited to cholestasis, cirrhosis, steatosis, alcoholic hepatitis, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), primary sclerosing cholangitis (PSC), elevated liver enzymes, and elevated triglyceride levels. In some embodiments, an FXR agonist is used in the prevention or treatment of alcoholic or non-alcoholic liver diseases. In some embodiments, an FXR agonist is used in the prevention or treatment of cholestasis, cirrhosis, steatosis, alcoholic hepatitis, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), or primary sclerosing cholangitis (PSC).Cholestasis

[0070] In some embodiments, an FXR agonist disclosed herein is used in the treatment of cholestasis in a subject. Cholestasis is an impairment or cessation in the flow of bile, which in some cases, causes hepatotoxicity due to the buildup of bile acids and other toxins in the liver. In some instances, cholestasis is a component of many liver diseases, including cholelithiasis, cholestasis of pregnancy, primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC). In some instances, the obstruction is due to gallstone, biliary trauma, drugs, one or more additional liver diseases, or to cancer. In some cases, the enterohepatic circulation of bile acids enables the absorption of fats and fat-soluble vitamins from the intestine and allows the elimination of cholesterol, toxins, and metabolic byproducts such as bilirubin from the liver. In some cases, activation of FXR induces expression of the canalicular bile transporters BSEP (ABCB11) and multidrug resistance-related protein 2 (MRP2; ABCC2, cMOAT), and represses genes involved in bile acid biosynthesis, such as for example sterol 12α-hydroxylase (CYP8B1) and CYP7A1.

[0071] In some examples, the FXR agonist reduces cholestasis in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some cases, cholestasis is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of cholestasis is relative to the level of cholestasis in a subject not treated with the FXR agonist.Primary Biliary Cirrhosis and Cirrhosis

[0072] In some embodiments, an FXR agonist disclosed herein is used in the treatment of primary biliary cirrhosis (PBC) in a subject. PBC is a liver disease that primarily results from autoimmune destruction of the bile ducts that transport bile acids (BAs) out of the liver, resulting in cholestasis. As PBC progresses, persistent toxic buildup of BAs causes progressive liver damage. Chronic inflammation and fibrosis can advance to cirrhosis. In some examples, the FXR agonist reduces PBC in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some cases, PBC is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of PBC is relative to the level of PBC in a subject not treated with the FXR agonist.

[0073] In some embodiments, an FXR agonist disclosed herein reduces cirrhosis in a subject. In some examples, the FXR agonist reduces cirrhosis in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some cases, cirrhosis is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of cirrhosis is relative to the level of cirrhosis in a subject not treated with the FXR agonist.Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

[0074] Non-alcoholic fatty liver disease (NAFLD) is associated with excessive fat in the liver (steatosis) and in some cases progresses to NASH, which is defined by the histologic hallmarks of inflammation, cell death, and fibrosis. In some instances, primary NASH is associated with insulin resistance, while secondary NASH is caused by medical or surgical conditions, or drugs such as, but not limited to, tamoxifen. In some cases, NASH progresses to advanced fibrosis, hepatocellular carcinoma, or end-stage liver disease requiring liver transplantation.

[0075] In some instances, NASH develops as a result of triglyceride (TGs) imbalance. For example, dysfunctional adipocytes secrete pro-inflammatory molecules such as cytokines and chemokines leading to insulin resistance and a failure of lipolysis suppression in the adipocytes. In some instances, this failure of lipolysis suppression leads to a release of free fatty acids (FFAs) into the circulation and uptake within the liver. In some cases, over accumulation of FFAs in the form of triglycerides (TGs) in lipid droplets leads to oxidative stress, mitochondrial dysfunction, and upregulation of pro-inflammatory molecules.

[0076] In some instances, activation of FXR inhibits triglyceride (TG) / fatty acid (FA) synthesis facilitated by suppressing sterol regulatory element-binding protein 1c (SREBP1c) via activation of SHP. In some cases, FXR additionally increases the clearance of TG by stimulating lipoprotein lipase (LPL) activity as well as the hepatic uptake of remnants and low-density lipoprotein by inducing syndecan 1 (SDC1) and the VLDL receptor (VLDLR).

[0077] In some embodiments, an FXR agonist disclosed herein is used in the treatment of non-alcoholic steatohepatitis (NASH). In some examples, the FXR agonist reduces NASH the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some cases, NASH is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of NASH is relative to the level of NASH in a subject not treated with the FXR agonist.

[0078] In some embodiments, an FXR agonist disclosed herein is used in the treatment of NAFLD. In some examples, the FXR agonist reduces NAFLD in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some cases, NAFLD is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of NAFLD is relative to the level of NAFLD in a subject not treated with the FXR agonist.Steatosis

[0079] In some embodiments, an FXR agonist disclosed herein reduces fatty liver (steatosis) in a subject. In some examples, the FXR agonist reduces steatosis in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, steatosis is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of steatosis is relative to the level of steatosis in a subject not treated with the FXR agonist.Ballooning

[0080] Hepatocyte ballooning, a feature denoting cellular injury, is a feature of NASH. Ballooning is a feature that denotes progressive NAFL (types 3 and 4). The term applies to enlarged, swollen-appearing hepatocytes; the affected cells are often intermixed in areas of steatosis and, in classic steatohepatitis, in the perivenular regions. Hepatocellular ballooning is most commonly noted in regions of H & E-detectable peri sinusoidal fibrosis. Ballooned hepatocytes are most easily noted when they contain MH (either typical or poorly formed). Hepatocyte ballooning is a structural manifestation of microtubular disruption and severe cell injury.

[0081] In some embodiments, an FXR agonist disclosed herein reduces liver ballooning in a subject. In some examples, the FXR agonist reduces liver ballooning in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, liver ballooning is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the liver ballooning is relative to the level of liver ballooning in a subject not treated with the FXR agonist.Alcoholic Hepatitis

[0082] In some embodiments, an FXR agonist disclosed herein reduces alcoholic hepatitis in a subject. In some examples, the FXR agonist reduces alcoholic hepatitis in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, the level of alcoholic hepatitis is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of alcoholic hepatitis is relative to the level of alcoholic hepatitis in a subject not treated with the FXR agonist.Primary Sclerosing Cholangitis

[0083] In some embodiments, an FXR agonist disclosed herein is used in the treatment of primary sclerosing cholangitis (PSC). PSC is a chronic and progressive cholestatic liver disease. PSC is characterized by progressive inflammation, fibrosis, and stricture formation in liver ducts. Common symptoms include pruritus and jaundice. The disease is strongly associated with inflammatory bowel disease (IBD) - about 5% of patients with ulcerative colitis will have PSC. Up to 70% of patients with PSC also have IBD, most commonly ulcerative colitis.Additional Alcoholic and Non-Alcoholic Liver Diseases or Conditions

[0084] In some embodiments, an FXR agonist disclosed herein reduces liver enzymes in a subject. In some examples, the FXR agonist reduce liver enzymes (e.g., serum ALT and / or AST levels) in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, the level of liver enzymes is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of liver enzymes is relative to the level of liver enzymes in a subject not treated with the FXR agonist.

[0085] In some embodiments, an FXR agonist disclosed herein reduces liver triglycerides in a subject. In some examples, the FXR agonist reduces liver triglycerides in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, the level of liver triglycerides is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of liver triglycerides is relative to the level of liver triglycerides in a subject not treated with the FXR agonist.Inflammatory Intestinal Condition

[0086] Disclosed herein are methods of treating or preventing an inflammatory intestinal condition. Exemplary inflammatory conditions include necrotizing enterocolitis (NEC), gastritis, ulcerative colitis, inflammatory bowel disease, irritable bowel syndrome, pseudomembranous colitis, gastroenteritis, radiation induced enteritis, chemotherapy induced enteritis, gastro-esophageal reflux disease (GERD), peptic ulcer, non-ulcer dyspepsia (NUD), celiac disease, intestinal celiac disease, gastrointestinal complications following bariatric surgery, gastric carcinogenesis, or gastric carcinogenesis following gastric or bowel resection. In some embodiments, the inflammatory condition is NEC and the subject is a newborn or prematurely born infant. In some embodiments, the subject is enterally-fed infant or formula-fed infant.

[0087] In some embodiments, an FXR agonist disclosed herein is administered to a subject having an inflammatory intestinal condition. In some embodiments, an FXR agonist disclosed herein is administered to a subject having necrotizing enterocolitis (NEC), gastritis, ulcerative colitis, inflammatory bowel disease, irritable bowel syndrome, pseudomembranous colitis, gastroenteritis, radiation induced enteritis, chemotherapy induced enteritis, gastro-esophageal reflux disease (GERD), peptic ulcer, non-ulcer dyspepsia (NUD), celiac disease, intestinal celiac disease, gastrointestinal complications following bariatric surgery, gastric carcinogenesis, or gastric carcinogenesis following gastric or bowel resection.

[0088] In some embodiments, an FXR agonist disclosed herein reduces inflammation of the intestines in a subject (such as a human). In some examples, the FXR agonist reduces intestinal inflammation in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, intestinal inflammation is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of intestinal inflammation is relative to the level of intestinal inflammation in a subject not treated with the FXR agonist.Gastrointestinal Diseases

[0089] Disclosed herein, in certain embodiments, are methods of treating or preventing a gastrointestinal disease in a subject in need thereof, comprising administering to the subject a farnesoid X receptor (FXR) agonist as described herein. In some embodiments, the gastrointestinal disease is irritable bowel syndrome (IBS), irritable bowel syndrome with diarrhea (IBS-D), irritable bowel syndrome with constipation (IBS-C), mixed IBS (IBS-M), unsubtyped IBS (IBS-U), or bile acid diarrhea (BAD).Irritable Bowel Syndrome

[0090] Irritable bowel syndrome (IBS) is a combination of symptoms including abdominal pain and changes in bowel movement patterns that persists over an extended period of time, often years. The causes of IBS remain unclear; however, gut motility problems, food sensitivity, genetic factors, small intestinal bacterial overgrowth, and gut-brain axis problems are thought to have a potential role. In some instances, IBS is accompanied with diarrhea and is categorized as IBS with diarrhea (IBS-D). In some instances, IBS is accompanied with constipation and is categorized as IBS with constipation (IBS-C). In some instances, IBS is accompanied with an alternating pattern of diarrhea and constipation and is categorized as mixed IBS (IBS-M). In some instances, IBS is not accompanied with either diarrhea or constipation and is categorized as unsubtyped IBS (IBS-U). In some instances, IBS has four different variations: IBS-D, IBS-C, IBS-M, and IBS-U.

[0091] In some embodiments, the symptoms of IBS are mimicked by a different condition. In some embodiments, sugar maldigestion, celiac disease, gluten intolerance without celiac disease, pancreatic exocrine insufficiency, small bowel bacterial overgrowth, microscopic colitis, or bile acid malabsorption (BAM) mimic IBS-D. In some embodiments, anismus, pelvic floor dyssynergia or puborectalis spasm, or descending perineum syndrome mimic IBS-C.

[0092] In some embodiments, an FXR agonist disclosed herein is used in the treatment of IBS or any of its variations in a mammal. In some examples, an FXR agonist therapeutic agent reduce IBS symptoms in the mammal by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more.Bile Acid Malabsorption

[0093] Bile acid malabsorption (BAM), also known as bile acid diarrhea (BAD), bile acid-induced diarrhea, cholerheic or choleretic enteropathy, or bile salt malabsorption, is a condition in which the presence of bile acids in the colon causes diarrhea. BAM is caused by a number of conditions such as Crohn's disease, cholecystectomy, coeliac disease, radiotherapy, and pancreatic diseases. In some instances, BAM is caused by medications such as metformin. In some embodiments, BAM is caused by an overproduction of bile acids. Bile acid synthesis is negatively regulated by the ileal hormone fibroblast growth factor 19 (FGF-19); low levels of FGF-19 lead to an increase in bile acids. FXR activation promotes the synthesis of FGF-19, consequently lowering the levels of bile acids.

[0094] In some embodiments, an FXR agonist disclosed herein is used in the treatment of BAM in a mammal. In some embodiments, an FXR agonist disclosed herein decreases bile acid synthesis. In some embodiments, an FXR agonist disclosed herein decreases bile acid levels. In some embodiments, an FXR agonist and an additional therapeutic agent disclosed herein prevent BAD. In some examples, an FXR agonist reduces BAM symptoms in the mammal by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more.Graft vs. Host Disease (GvHD)

[0095] Graft vs. host disease (GvHD) is a medical complication that arises after a transplant of tissue or cells from a histo-incompatible donor (i.e. a genetically or immunologically different donor). Immune cells in the donated tissue or cells (graft) recognize the recipient (the host) as foreign and initiate and attack. Non-limiting examples of transplanted tissue or cells that give rise to GvHD are blood products, stem cells such as bone marrow cells, and organs. There are different types of GvHD depending on where the symptoms manifest or develop: skin GvHD, liver GvHD, eye GvHD, neuromuscular GvHD, genitourinary tract GvHD, and gastrointestinal (GI) tract GvHD. Symptoms of GI tract GvHD include difficulty swallowing, pain with swallowing, weight loss, nausea, vomiting, diarrhea, and / or abdominal cramping. GI tract GvHD results in sloughing of the mucosal membrane and severe intestinal inflammation. Inflammation of the biliary epithelium is amenable to be controlled by nuclear receptors such as the glucocorticoid receptor (GR), FXR, or the peroxisome proliferator-activated receptors (PPARs).

[0096] In some embodiments, an FXR agonist disclosed herein is used in the treatment of GvHD or a complication of GvHD in a mammal. In some embodiments, an FXR agonist disclosed herein is used in the treatment of GI tract GvHD or a complication of GI tract GvHD in a mammal. In some examples, an FXR agonist reduces GI tract GvHD or a complication of GI tract GvHD in the mammal by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some cases, GI tract GvHD or a complication of GI tract GvHD is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some embodiments, an FXR agonist disclosed herein decreases intestinal inflammation caused by GI tract GvHD. In some embodiments, an FXR agonist disclosed herein reduces intestinal inflammation caused by GI tract GvHD reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%.Kidney Diseases

[0097] Disclosed herein, in certain embodiments, are methods of treating or preventing a kidney disease in a subject in need thereof, comprising administering to the subject a farnesoid X receptor (FXR) agonist described herein. In some embodiments, the kidney disease is associated with a liver disease. In some embodiments, the kidney disease is associated with a fibrotic liver disease. In some embodiments, the kidney disease is associated with a metabolic liver disease. In some embodiments, the kidney disease is associated with a metabolic condition such as but not limited to diabetes, metabolic syndrome, NAFLD, insulin resistance, fatty acid metabolism disorder, and cholestasis. In some embodiments, the kidney disease is diabetic nephropathy, kidney disease associated with fibrosis, kidney disease not associated with fibrosis, renal fibrosis, or any combination thereof.Diabetic Nephropathy

[0098] Diabetic nephropathy is a kidney disease characterized by damage to the kidney's glomeruli. Diabetes contributes to an excessive production of reactive oxygen species, which leads to nephrotic syndrome and scarring of the glomeruli. As diabetic nephropathy progresses, the glomerular filtration barrier (GFB) is increasingly damaged and consequently, proteins in the blood leak through the barrier and accumulate in the Bowman's space.

[0099] In some embodiments, an FXR agonist disclosed herein is used in the treatment of diabetic nephropathy in a mammal.Renal Fibrosis

[0100] Renal fibrosis is characterized by activation of fibroblasts and excessive deposition of extracellular matrix or connective tissue in the kidney, which is a hallmark of chronic kidney disease. FXR plays an important role in protecting against renal fibrosis. Activation of FXR suppresses renal fibrosis and decreases accumulation of extracellular matrix proteins in the kidney.

[0101] In some embodiments, an FXR agonist disclosed herein is used in the treatment of renal fibrosis in a mammal.

[0102] In one aspect, described herein is a method of treating or preventing a kidney disease or condition in a mammal, comprising administering to the mammal an FXR agonist disclosed herein, or a pharmaceutically acceptable salt or solvate thereof. In some embodiments, the kidney disease or condition is diabetic nephropathy, kidney disease associated with fibrosis, kidney disease not associated with fibrosis, renal fibrosis, kidney disease associated with a metabolic disease, chronic kidney disease, polycystic kidney disease, acute kidney disease, or any combination thereof.Cell Proliferation Disease

[0103] Further disclosed herein are methods of preventing or treating cell proliferation diseases, for example, in certain types of cancer. In some embodiments, the FXR agonists disclosed herein are used in the prevention or treatment of adenocarcinomas, or a carcinoma derived from glandular tissue or in which the tumor cells form recognizable glandular structures. In some embodiments, adenocarcinomas are classified according to the predominant pattern of cell arrangement, as papillary, alveolar, or according to a particular product of the cells, as mucinous adenocarcinoma. In some instances, adenocarcinomas are observed for example, in colon, kidney, breast, cervix, esophagus, gastric, pancreas, prostate, or lung.

[0104] In some embodiments, the compounds disclosed herein are used in the prevention or treatment of a cancer of the intestine, such as colon cancer, e.g., cancer that forms in the tissues of the colon (the longest part of the large intestine), or a cancer of another part of the intestine, such as the jejunum, and / or ileum. In some instances, colon cancer is also referred to as "colorectal cancer." In some instances, the most common type of colon cancer is colon adenocarcinoma.

[0105] In some cases, cancer progression is characterized by stages, or the extent of cancer in the body. Staging is usually based on the size of the tumor, the presence of cancer in the lymph nodes, and the presence of the cancer in a site other than the primary cancer site. Stages of colon cancer include stage I, stage II, stage III, and stage IV. In some embodiments, colon adenocarcinoma is from any stage. In other embodiments, colon adenocarcinoma is a stage I cancer, a stage II cancer, or a stage III cancer.

[0106] In some embodiments, an FXR agonist described herein is administered to a subject having a stage I, stage II, stage III, or stage IV cancer. In some instances, an FXR agonist described herein is administered to a subject having a stage I, stage II, or stage III colon adenocarcinoma.

[0107] In some embodiments, an FXR agonist disclosed herein further reduces the tumor burden in a subject. In some examples, the FXR agonist reduces tumor burden (such as colon tumor burden) in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, tumor burden is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the level of tumor burden is relative to the level of tumor burden in a subject not treated with the FXR agonist.

[0108] In some instances, an FXR agonist disclosed herein further reduces tumor size and / or volume in a subject. In some cases, the FXR agonist reduces tumor size and / or volume (such as a colon tumor) in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, tumor size is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the tumor size is relative to the tumor size in a subject not treated with the FXR agonist.

[0109] In additional embodiments, an FXR agonist disclosed herein reduces effects of cachexia due to a tumor in a subject. In some examples, the FXR agonist reduces the effect of cachexia (such as due to a colon tumor) in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, the effect of cachexia is reduced by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the effect of cachexia is relative to the effect of cachexia in a subject not treated with the FXR agonist.

[0110] In other embodiments, an FXR agonist disclosed herein increases survival rates of a subject with a tumor. In some cases, the FXR agonist increases the survival rate of a subject with a tumor (such as a colon cancer) in the subject by at least 5%, at least 10%, at least 15%, at least 20%, at least 30%, at least 40%, at least 50%, or more. In some instances, survival rate is increased by about 5% to about 50%, by about 5% to about 25%, by about 10% to about 20%, or by about 10% to about 30%. In some instances, the survival rate is relative to the survival rate in a subject not treated with the FXR agonist.Compounds

[0111] Compounds described herein, including pharmaceutically acceptable salts, prodrugs, active metabolites and pharmaceutically acceptable solvates thereof, are farnesoid X receptor agonists.

[0112] In some embodiments is a compound of Formula (I'), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, pyrazolyl, furanyl, thienyl, pyrrolyl, imidazolyl, triazolyl, tetrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, or thiadiazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, or triazinyl; X 1< , X 5< , X 6< , and X 7< are each independently CR 7< or N; wherein at least one of X 1< , X 5< , X 6< , and X 7< are CR 7< ; R 1< is selected from H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), - S(=O) 2 N(R 17< ) 2 , -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , - NR 15< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, and monocyclic C 2 -C 5 heterocycloalkyl; X 2< is CR 2< or N; R 2< is H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , -NR 17< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, or monocyclic C 2 -C 5 heterocycloalkyl; or R 1< and R 2< are taken together with the intervening atoms to form a fused 5- or 6-membered ring with 0-3 N atoms and 0-2 O or S atoms in the ring, wherein the fused 5- or 6-membered ring is optionally substituted with halogen or C 1 -C 4 alkyl; X 3< is CR 3< or N; R 3< is H, halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl; each X 4< is independently CH, CF, or N; R 4< is H, F, or -CH 3 ; R 5< is H, F, or -CH 3 ; or R 4< and R 5< are taken together to form a bridge that is -CH 2 - or -CH 2 CH 2 -; each R 6< is independently H, F, -OH, or -CH 3 ; L is absent, -Y 2< -L 1< -, -L 1< -Y 2< -, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y 2< is absent, -O-, -S-, -S(=O)-, -S(=O) 2 -, -S(=O) 2 NR 17< -, -CH 2 -, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR 17< -, -NR 17< C(=O)-, - OC(=O)NR 17< -, -NR 17< C(=O)O-, -NR 17< C(=O)NR 17< -, -NR 17< S(=O) 2 -, or -NR 17< -; L 1< is absent or C 1 -C 4 alkylene; each R 7< is independently selected from H, halogen, -CN, -OH, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 3 -C 6 cycloalkyl, and C 1 -C 4 heteroalkyl; R 8< is C 4 -C 8 alkyl or C 4 -C 8 haloalkyl; R 9< is H, F, or -CH 3 ; R 10< is -OC(=O)N(R 12< )(R 13< ), -N(R 16< )C(=O)R 14< , or -N(R 16< )C(=O)OR 15< ; R 11< is H, F, or -CH 3 ; R 12< is -C 1 -C 6 alkyl-OR 17< or monocyclic C 2 -C 5 heterocycloalkyl optionally substituted with one or two oxo groups; R 13< is H or C 1 -C 4 alkyl; or R 12< and R 13< are taken together to form a 4-, 5-, or 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -S(C 1 -C 4 alkyl), - S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), -C 1 -C 4 alkyl-S(=O) 2 (C 1 -C 4 alkyl), -C 1 -C 6 alkyl-OR 17< , and -O-C 1 -C 6 alkyl-OR 17< ; R 14< is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, or -C 1 -C 6 alkyl-OR 17< ; R 15< is C 1 -C 6 alkyl, -C 1 -C 6 alkyl-OR 17< , C 3 -C 6 cycloalkyl, or C 2 -C 6 heterocycloalkyl; R 16< is H or C 1 -C 6 alkyl; each R 17< is independently H or C 1 -C 6 alkyl; each R 18< is independently halogen, -CN, -OH, -N(R 17< )2, -NR 17< S(=O) 2 (C 1 -C 4 alkyl), - S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - C(=O)(C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), - NR 17< C(=O)(C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)O(C 1 -C 4 alkyl), - OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, monocyclic C 2 -C 6 heterocycloalkyl, phenyl, or monocyclic heteroaryl; m is 0, 1, or 2; and n is 0, 1, or 2.

[0113] In some embodiments is a compound of Formula (I') having the structure of Formula (Ia'), or a pharmaceutically acceptable salt or solvate thereof:

[0114] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< is N, and X 5< , X 6< , and X 7< are CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 5< is N, and X 1< , X 6< , and X 7< are CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 6< is N, and X 1< , X 5< , and X 7< are CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 7< is N, and X 1< , X 5< , and X 6< are CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< and X 6< are N, and X 5< and X 7< are CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< and X 7< are N, and X 5< and X 6< are CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< , X 5< , X 6< , and X 7< are CH.

[0115] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein n is 0.

[0116] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is

[0117] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is C 4 -C 8 alkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 3 ) 3 . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 2 CH 3 ) 3 . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 2 CH 3 ) 2 CH 3 . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is - C(CH 3 ) 2 CH 2 CH 3 . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is C 1 -C 8 haloalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 3 ) 2 CF 3 .

[0118] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< is H and R 5< is H. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 CH 2 -. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 -.

[0119] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0 or 1. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0. In some embodiment is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 1. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 2.

[0120] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -OC(=O)N(R 12< )(R 13< ). In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 4-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 4-membered heterocycloalkyl ring optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 5-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is

[0121] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -N(R 16< )C(=O)R 14< . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is C 1 -C 6 alkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OR 17< . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OCH 3 .

[0122] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -N(R 16< )C(=O)OR 15< . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is C 1 -C 6 alkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OR 17< . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OCH 3 . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is C 2 -C 6 heterocycloalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is or In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 16< is H.

[0123] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, -CN, -OH, -N(R 17< )2, -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , - NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, -CN, -OH, -N(R 17< )2, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, -CN, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl or C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is halogen. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -F. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -Cl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -CH 3 . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is - OCH 3 . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -CF 3 .

[0124] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein one X 4< is CH and one X 4< is N. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein each X 4< is CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein one X 4< is CF and one X 4< is N. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein one X 4< is CF and one X 4< is CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein each X 4< is CF.

[0125] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is CR 3< . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is CH. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is N.

[0126] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, -CN, -OH, -N(R 17< ) 2 , -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), - NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, - CN, -OH, -N(R 15< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, -CN, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen or C 1 -C 4 alkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -F. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -Cl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -CH 3 . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -OCH 3 . In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -CF 3 .

[0127] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is N.

[0128] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein each R 7< is H.

[0129] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein L is absent.

[0130] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 9< is H.

[0131] In some embodiments is a compound of Formula (I') or (Ia'), or a pharmaceutically acceptable salt or solvate thereof, wherein R 11< is H.

[0132] In some embodiments is a compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, pyrazolyl, furanyl, thienyl, pyrrolyl, imidazolyl, triazolyl, tetrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, or thiadiazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, or triazinyl; X 1< is C(H), C(F), or N; R 1< is selected from H, halogen, -CN, -OH, -N(R 17< ) 2 , -NR 17< S(=O) 2 (C 1 -C 4 alkyl), - S(=O) 2 N(R 17< ) 2 , -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , - NR 15< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, and monocyclic C 2 -C 5 heterocycloalkyl; X 2< is CR 2< or N; R 2< is H, halogen, -CN, -OH, -N(R 17< ) 2 , -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , -NR 17< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl; or R 1< and R 2< are taken together with the intervening atoms to form a fused 5- or 6-membered ring with 0-3 N atoms and 0-2 O or S atoms in the ring, wherein the fused 5- or 6-membered ring is optionally substituted with halogen or C 1 -C 4 alkyl; X 3< is CR 3< or N; R 3< is H, halogen, -CN, -OH, -N(R 17< ) 2 , -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl; each X 4< is independently CH or N; R 4< is H, F, or -CH 3 ; R 5< is H, F, or -CH 3 ; or R 4< and R 5< are taken together to form a bridge that is -CH 2 - or -CH 2 CH 2 -; each R 6< is independently H, F, -OH, or -CH 3 ; L is absent, -Y 2< -L 1< -, -L 1< -Y 2< -, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y 2< is absent, -O-, -S-, -S(=O)-, -S(=O) 2 -, -S(=O) 2 NR 17< -, -CH 2 -, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR 17< -, -NR 17< C(=O)-, - OC(=O)NR 17< -, -NR 17< C(=O)O-, -NR 17< C(=O)NR 17< -, -NR 17< S(=O) 2 -, or -NR 17< -; L 1< is absent or C 1 -C 4 alkylene; each R 7< is independently selected from H, halogen, -CN, -OH, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, and C 1 -C 4 heteroalkyl; R 8< is C 4 -C 8 alkyl or C 4 -C 8 haloalkyl; R 9< is H, F, or -CH 3 ; R 10< is -OC(=O)N(R 12< )(R 13< ), -N(R 16< )C(=O)R 14< , or -N(R 16< )C(=O)OR 15< ; R 11< is H, F, or -CH 3 ; R 12< is -C 1 -C 6 alkyl-OR 17< or monocyclic C 2 -C 5 heterocycloalkyl optionally substituted with one or two oxo groups; R 13< is H or C 1 -C 4 alkyl; or R 12< and R 13< are taken together to form a 4-, 5-, or 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, -S(C 1 -C 4 alkyl), - S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), -C 1 -C 4 alkyl-S(=O) 2 (C 1 -C 4 alkyl), -C 1 -C 6 alkyl-OR 17< , and -O-C 1 -C 6 alkyl-OR 17< ; R 14< is C 1 -C 6 alkyl or -C 1 -C 6 alkyl-OR 17< ; R 15< is C 1 -C 6 alkyl, -C 1 -C 6 alkyl-OR 17< , or C 2 -C 6 heterocycloalkyl; R 16< is H or C 1 -C 6 alkyl; each R 17< is independently H or C 1 -C 6 alkyl; each R 18< is independently halogen, -CN, -OH, -N(R 17< ) 2 , -NR 17< S(=O) 2 (C 1 -C 4 alkyl), - S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - C(=O)(C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), - NR 17< C(=O)(C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)O(C 1 -C 4 alkyl), - OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, monocyclic C 2 -C 6 heterocycloalkyl, phenyl, or monocyclic heteroaryl; m is 0, 1, or 2; and n is 0, 1, or 2.

[0133] In some embodiments is a compound of Formula (I) having the structure of Formula (Ia), or a pharmaceutically acceptable salt or solvate thereof:

[0134] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein n is 0.

[0135] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is

[0136] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is C 4 -C 8 alkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 3 ) 3 . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 2 CH 3 ) 3 . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 2 CH 3 ) 2 CH 3 . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is - C(CH 3 ) 2 CH 2 CH 3 . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is C 1 -C 8 haloalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 3 ) 2 CF 3 .

[0137] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< is H and R 5< is H. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 CH 2 -. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 -.

[0138] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0 or 1. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0. In some embodiment is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 1. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 2.

[0139] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< is C(H). In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< is C(F). In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< is N.

[0140] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -OC(=O)N(R 12< )(R 13< ). In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 4-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 4-membered heterocycloalkyl ring optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 5-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, - N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, - N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is

[0141] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -N(R 16< )C(=O)R 14< . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is C 1 -C 6 alkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OR 17< . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OH. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OCH 3 .

[0142] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -N(R 16< )C(=O)OR 15< . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is C 1 -C 6 alkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OR 17< . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OH. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OCH 3 . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is C 2 -C 6 heterocycloalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 16< is H.

[0143] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, -CN, -OH, -N(R 17< ) 2 , -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , - NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, -CN, -OH, -N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, -CN, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl or C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is halogen. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -F. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -Cl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -CH 3 . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -OCH 3 . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -CF 3 .

[0144] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein one X 4< is CH and one X 4< is N. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein each X 4< is CH.

[0145] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is CR 3< . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is CH. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is N.

[0146] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, -CN, -OH, -N(R 17< ) 2 , -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), - NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, - CN, -OH, -N(R 15< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, -CN, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen or C 1 -C 4 alkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -F. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -Cl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -CH 3 . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -OCH 3 . In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -CF 3 .

[0147] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is N.

[0148] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein each R 7< is H.

[0149] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein L is absent.

[0150] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 9< is H.

[0151] In some embodiments is a compound of Formula (I) or (Ia), or a pharmaceutically acceptable salt or solvate thereof, wherein R 11< is H.

[0152] In some embodiments, described herein is a compound of Formula (II), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is X 1< is CH or N; R 1< is H, halogen, -CN, -OH, -N(R 17< ) 2 , -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , -NR 15< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl; X 2< is CR 2< or N; R 2< is H, halogen, -CN, -OH, -N(R 17< ) 2 , -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , -NR 17< C(=O)N(R 17< ) 2 , -SH, -S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl; or R 1< and R 2< are taken together with the intervening atoms to form a fused 5- or 6-membered ring with 0-3 N atoms and 0-2 O or S atoms in the ring, wherein the fused 5- or 6-membered ring is optionally substituted with halogen or C 1 -C 4 alkyl; X 3< is CR 3< or N; R 3< is H, halogen, -CN, -OH, -N(R 17< ) 2 , -NR 17< S(=O) 2 (C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl; each X 4< is independently CH or N; R 4< is H, F, or -CH 3 ; R 5< is H, F, or -CH 3 ; or R 4< and R 5< are taken together to form a bridge that is -CH 2 - or -CH 2 CH 2 -; each R 6< is independently H, F, -OH, or -CH 3 ; R 7< is H, halogen, -CN, -OH, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl; L is absent, -Y 2< -L 1< -, -L 1< -Y 2< -, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y 2< is absent, -O-, -S-, -S(=O)-, -S(=O) 2 -, -S(=O) 2 NR 17< -, -CH 2 -, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR 17< -, -NR 17< C(=O)-, - OC(=O)NR 17< -, -NR 17< C(=O)O-, -NR 17< C(=O)NR 17< -, -NR 17< S(=O) 2 -, or -NR 17< -; L 1< is absent or C 1 -C 4 alkylene; R 8< is C 4 -C 8 alkyl; R 9< is H, F, or -CH 3 ; R 10< is -OC(=O)N(R 12< )(R 13< ), -N(R 16< )C(=O)R 14< , or -N(R 16< )C(=O)OR 15< ; R 11< is H, F, or -CH 3 ; R 12< and R 13< are taken together to form a 4-, 5-, or 6- membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy; R 14< is C 1 -C 6 alkyl or -C 1 -C 6 alkyl-OR 17< ; R 15< is C 1 -C 6 alkyl, -C 1 -C 6 alkyl-OR 17< , or C 2 -C 6 heterocycloalkyl; R 16< is H or C 1 -C 6 alkyl; each R 17< is independently H or C 1 -C 6 alkyl; and m is 0, 1, or 2.

[0153] In some embodiments is a compound of Formula (II) having the structure of Formula (IIa), or a pharmaceutically acceptable salt or solvate thereof:

[0154] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is

[0155] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 3 ) 3 . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -CH 2 C(CH 3 ) 3 . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 2 CH 3 ) 3 . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 2 CH 3 ) 2 CH 3 . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is - C(CH 3 ) 2 CH 2 CH 3 .

[0156] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< is H and R 5< is H. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 CH 2 -. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 -.

[0157] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0 or 1. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0. In some embodiment is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 1. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 2.

[0158] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< is CH. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein each X 1< is N.

[0159] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -OC(=O)N(R 12< )(R 13< ). In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 4-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 4-membered heterocycloalkyl ring optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 5-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 12< and R 13< are taken together to form a 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 6 alkyl, and C 1 -C 6 alkoxy. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is

[0160] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -N(R 16< )C(=O)R 14< . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is C 1 -C 6 alkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OR 17< . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OH. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OCH 3 .

[0161] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -N(R 16< )C(=O)OR 15< . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is C 1 -C 6 alkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OR 17< . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OH. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is -C 1 -C 6 alkyl-OCH 3 . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is C 2 -C 6 heterocycloalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is or In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 16< is H.

[0162] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, -CN, -OH, -N(R 17< ) 2 , -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , - NR 17< C(=O)(C 1 -C 4 alkyl), -NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, -CN, -OH, -N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, -CN, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H, halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl or C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is H. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is halogen. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -F. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -Cl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -CH 3 . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is - OCH 3 . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -CF 3 .

[0163] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein one X 4< is CH and one X 4< is N. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein each X 4< is CH.

[0164] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is CR 3< . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is CH. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 3< is N.

[0165] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, -CN, -OH, -N(R 17< ) 2 , -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 17< ) 2 , - OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)N(R 17< ) 2 , -NR 17< C(=O)(C 1 -C 4 alkyl), - NR 17< C(=O)O(C 1 -C 4 alkyl), -OC(=O)N(R 17< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, - CN, -OH, -N(R 15< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, or monocyclic C 2 -C 5 heterocycloalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, -CN, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen or C 1 -C 4 alkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is halogen. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -F. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -Cl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -CH 3 . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -OCH 3 . In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is C 1 -C 4 fluoroalkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is CR 2< and R 2< is -CF 3 .

[0166] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 2< is N.

[0167] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 7< is H. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 7< is halogen. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 7< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 7< is C 1 -C 4 fluoroalkyl.

[0168] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein L is absent.

[0169] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 9< is H.

[0170] In some embodiments is a compound of Formula (II) or (IIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 11< is H.

[0171] In some embodiments is a compound of Formula (III), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, pyrazolyl, furanyl, thienyl, pyrrolyl, imidazolyl, triazolyl, tetrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, or thiadiazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, or triazinyl; or ring A is phenyl; X 1< is CH or N; R 1< is C 1 -C 4 alkoxy; R 2< is halogen; R 4< is H, F, or -CH 3 ; R 5< is H, F, or -CH 3 ; or R 4< and R 5< are taken together to form a bridge that is -CH 2 - or -CH 2 CH 2 -; each R 6< is independently H, F, -OH, or -CH 3 ; R 7< is H, halogen, -CN, -OH, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, or C 1 -C 4 heteroalkyl; L is absent, -Y 2< -L 1< -, -L 1< -Y 2< -, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y 2< is absent, -O-, -S-, -S(=O)-, -S(=O) 2 -, -S(=O) 2 NR 17< -, -CH 2 -, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR 17< -, -NR 17< C(=O)-, - OC(=O)NR 17< -, -NR 17< C(=O)O-, -NR 17< C(=O)NR 17< -, -NR 17< S(=O) 2 -, or -NR 17< -; L 1< is absent or C 1 -C 4 alkylene; R 8< is C 4 -C 8 alkyl or C 4 -C 8 haloalkyl; R 9< is H, F, or -CH 3 ; R 10< is -CH 2 OH, -CH 2 CH 2 OH, C 1 -C 6 heteroalkyl, -C(=O)R 14< , -C(=O)OR 14< , - OC(=O)R 14< , -OC(=O)OR 14< , tetrazolyl, imidazole, 5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl, -S(=O) 2 N(R 12< ) 2 , -NR 15< S(=O) 2 R 14< , -C(=O)NR 15< S(=O) 2 R 14< , - S(=O) 2 NR 15< C(=O)R 14< , -CH 2 N(R 12< ) 2 , -NR 15< C(=O)R 14< , -C(=O)N(R 12< ) 2 , - NR 15< C(=O)OR 14< , -OC(=O)N(R 12< ) 2 , -NR 15< C(=O)N(R 12< ) 2 , -C(=NH)NH 2 , - NHC(=NH)NH 2 , -C(=O)NHC(=NH)NH 2 , -S(=O) 2 OH or -OP(=O)(OR 15< ) 2 ; or R 10< is -L 2< -L 3< -L 4< -R 13< ; L 2< is absent, C 1 -C 6 alkylene, or C 1 -C 6 heteroalkylene; L 3< is absent, -O-, -S-, -S(=O)-, -S(=O) 2- , -NR 15< -, -C(=O)-, -C(=O)NR 15< -, - NR 15< C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)NR 15< -, -NR 15< C(=O)NR 15< -, - NR 15< C(=O)O-, -OP(=O)(OR 15< )O-, or -(OCH 2 CH 2 ) r -, r is 1 or 2; L 4< is C 1 -C 6 alkylene or C 1 -C 6 heteroalkylene; R 13< is H, -CN, -OH, -N(R 12< ) 2 , -NR 15< S(=O) 2 R 14< , -S(=O) 2 N(R 12< ) 2 , -SR 12< , -S(=O)R 14< , -S(=O) 2 R 14< , -SO 3 H, -OP(=O)(OR 15< ) 2 , -C(=O)R 14< , -OC(=O)R 14< , -CO 2 H, - CO 2 R 14< , -OC(=O)OR 14< , -NR 15< C(=O)R 14< , -C(=O)N(R 12< ) 2 , -NR 15< C(=O)OR 14< , - OC(=O)N(R 12< ) 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 heteroalkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 heterocycloalkyl, phenyl, or heteroaryl; R 11< is H, F, or -CH 3 ; or R 9< and R 11< are taken together to form a bridge that is -CH 2 - or -CH 2 CH 2 -; each R 12< is independently H, C 1 -C 4 alkyl, -C 1 -C 4 alkyl-OR 15< , C 1 -C 4 fluoroalkyl, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 heterocycloalkyl, phenyl, benzyl, or monocyclic heteroaryl, wherein C 3 -C 6 cycloalkyl, C 2 -C 6 heterocycloalkyl, phenyl, benzyl, or monocyclic heteroaryl are optionally substituted with 1, 2, or 3 R 16< groups; R 14< is C 1 -C 4 alkyl, -C 1 -C 4 alkyl-OR 15< , C 1 -C 4 fluoroalkyl, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, C 2 -C 6 heterocycloalkyl, phenyl, benzyl, or monocyclic heteroaryl, wherein C 3 -C 6 cycloalkyl, C 2 -C 6 heterocycloalkyl, phenyl, benzyl, or monocyclic heteroaryl are optionally substituted with 1, 2, or 3 R 16< groups; each R 15< is independently H or C 1 -C 6 alkyl; each R 16< is independently halogen, -CN, -OH, -N(R 15< ) 2 , -NR 15< S(=O) 2 (C 1 -C 4 alkyl), - S(C 1 -C 4 alkyl), -S(=O)(C 1 -C 4 alkyl), -S(=O) 2 (C 1 -C 4 alkyl), -S(=O) 2 N(R 15< ) 2 , - C(=O)(C 1 -C 4 alkyl), -OC(=O)(C 1 -C 4 alkyl), -CO 2 H, -CO 2 (C 1 -C 4 alkyl), - NR 15< C(=O)(C 1 -C 4 alkyl), -C(=O)N(R 15< ) 2 , -NR 15< C(=O)O(C 1 -C 4 alkyl), - OC(=O)N(R 15< ) 2 , C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkyl, C 1 -C 4 fluoroalkoxy, C 1 -C 4 heteroalkyl, C 3 -C 6 cycloalkyl, monocyclic C 2 -C 6 heterocycloalkyl, phenyl, or monocyclic heteroaryl; m is 0, 1, or 2; and n is 0, 1, or 2.

[0172] In some embodiments is a compound of Formula (III), or a pharmaceutically acceptable salt or solvate thereof, wherein n is 0.

[0173] In some embodiments is a compound of Formula (III), or a pharmaceutically acceptable salt or solvate thereof, wherein n is 1 or 2. In some embodiments is a compound of Formula (III), or a pharmaceutically acceptable salt or solvate thereof, wherein n is 1. In some embodiments is a compound of Formula (III), or a pharmaceutically acceptable salt or solvate thereof, wherein n is 2.

[0174] In some embodiments is a compound of Formula (III) having the structure of Formula (IIIa), or a pharmaceutically acceptable salt or solvate thereof:

[0175] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, or pyrazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl or pyrimidinyl. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, or pyrazolyl. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is a 6-membered heteroaryl that is pyridinyl or pyrimidinyl. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is phenyl.

[0176] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein

[0177] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is C 4 -C 8 alkyl. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is -C(CH 3 ) 3 . In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 8< is C 4 -C 8 haloalkyl.

[0178] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< is H and R 5< is H. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 CH 2 -. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 4< and R 5< are taken together to form a bridge that is -CH 2 -.

[0179] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0 or 1. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0. In some embodiment is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 1. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein m is 2.

[0180] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein X 1< is CH. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein each X 1< is N.

[0181] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -CH 2 OH, C 1 -C 6 heteroalkyl, -OC(=O)R 14< , -NR 15< C(=O)R 14< , -C(=O)N(R 12< ) 2 , -NR 15< C(=O)OR 14< , or - OC(=O)N(R 12< ) 2 . In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -OC(=O)R 14< . In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is C 2 -C 6 heterocycloalkyl optionally substituted with 1, 2, or 3 R 16< groups. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is C 2 -C 6 heterocycloalkyl optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 4 alkyl, and C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is a 4-membered heterocycloalkyl ring optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 4 alkyl, and C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is a 5-membered heterocycloalkyl ring optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 4 alkyl, and C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is a 4-membered heterocycloalkyl ring optionally substituted with 1 or 2 groups selected from -OH, -N(C 1 -C 4 alkyl) 2 , C 1 -C 4 alkyl, and C 1 -C 4 alkoxy. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is

[0182] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -OC(=O)N(R 12< ) 2 . In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein each R 12< is independently H, C 1 -C 4 alkyl, or -C 1 -C 4 alkyl-OR 15< . In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -OC(=O)N(H)-C 1 -C 4 alkyl. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -OC(=O)N(H)-C 1 -C 4 alkyl-OR 15< . In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is

[0183] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 10< is -N(R 15< )C(=O)OR 14< . In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OH. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is -C 1 -C 6 alkyl-OCH 3 . In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is C 2 -C 6 heterocycloalkyl. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 14< is In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 15< is H.

[0184] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1< is -OCH 3 .

[0185] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 2< is -F. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 2< is -Cl.

[0186] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 7< is H. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 7< is halogen. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 7< is C 1 -C 4 alkyl. In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 7< is C 1 -C 4 fluoroalkyl.

[0187] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein L is absent.

[0188] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 9< is H.

[0189] In some embodiments is a compound of Formula (III) or (IIIa), or a pharmaceutically acceptable salt or solvate thereof, wherein R 11< is H.

[0190] Any combination of the groups described above for the various variables is contemplated herein. Throughout the specification, groups and substituents thereof are chosen by one skilled in the field to provide stable moieties and compounds.

[0191] In some embodiments, compounds described herein include, but are not limited to, those described in Table 1. TABLE 1 Compound Structure Chemical Name 1 trans-4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)(((trans)-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl (tetrahydro-2H-pyran-4-yl)carbamate1.01 trans-4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)(((trans)-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl 3-hydroxyazetidine-1-carboxylate1.02 trans-4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)(((trans)-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl 3-hydroxy-2,2-dimethylazetidine-1-carboxylate1.03 trans-4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)(((trans)-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl 4-hydroxypiperidine-1-carboxylate1.04 trans-4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)(((trans)-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl 3-hydroxyazetidine-1-carboxylate1.05 trans-4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)(((trans)-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl 3-hydroxy-2,2-dimethylazetidine-1-carboxylate1.06 trans-4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)(((trans)-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl 4-hydroxypiperidine-1-carboxylate1.07 trans-4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)(((trans)-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl (tetrahydro-2H-pyran-4-yl)carbamate1.08 trans-4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl 3-hydroxyazetidine-1-carboxylate1.09 trans-4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl 3-hydroxy-2,2-dimethylazetidine-1-carboxylate1.10 trans-4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl 4-hydroxypiperidine-1-carboxylate1.11 trans-4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)carbamoyl)cy clohexyl (tetrahydro-2H-pyran-4-yl)carbamate1.12 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)-5-fluoropyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate1.13 4-((2-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-4-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate1.14 4-((5-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-3-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate1.15 4-((6-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate2 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) (3-hydroxypropyl)carbamate2.01 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxy-3-methylazetidine-1-carboxylate2.02 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) (3-hydroxypropyl)carbamate2.03 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-(methylsulfonyl)azetidine-1-carboxylate2.04 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) oxetan-3-ylcarbamate2.05 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 4-hydroxypiperidine-trans-1-carboxylate2.06 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl (2-hydroxyethyl)trans-carbamate2.07 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-(2-hydroxyethoxy)azetidine-1-carboxylate2.08 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) (3-hydroxy-3-methylbutyl)carbamate2.09 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-(dimethylamino)pyrrolidine-trans-1-carboxylate2.10 (S)-4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 2-(hydroxymethyl)azetidine-trans-1-carboxylate2.11 (S)-4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 2-(hydroxymethyl)azetidine-trans-1-carboxylate2.12 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxy-3-methylazetidine-1-carboxylate2.13 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-(methylsulfonyl)azetidine-1-carboxylate2.14 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-(2-hydroxyethoxy)azetidine-1-carboxylate2.15 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-(hydroxymethyl)azetidine-1-carboxylate2.16 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-(dimethylamino)pyrrolidine-trans-1-carboxylate2.17 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 4-hydroxypiperidine-trans-1-carboxylate2.18 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) oxetan-3-ylcarbamate2.19 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl (2-hydroxyethyl)trans-carbamate2.20 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) (3-hydroxy-3-methylbutyl)carbamate2.21 (S)-4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 2-(hydroxymethyl)azetidine-trans-1-carboxylate2.22 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxy-3-methylazetidine-1-carboxylate2.23 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-(methylsulfonyl)azetidine-1-carboxylate2.24 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-((methylsulfonyl)methyl)azetidine-1-carboxylate2.25 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-(2-hydroxyethoxy)azetidine-1-carboxylate2.26 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-(dimethylamino)pyrrolidine-trans-1-carboxylate2.27 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 4-hydroxypiperidine-trans-1-carboxylate2.28 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) oxetan-3-ylcarbamate2.29 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl trans(tetrahydro-2H-thiopyran-4-yl)carbamate2.30 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl (2-hydroxyethyl)trans-carbamate2.31 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) (3-hydroxypropyl)carbamate2.32 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) (3-hydroxy-3-methylbutyl)carbamate2.33 (R)-4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl trans-3-hydroxypyrrolidine-1-carboxylate2.34 (S)-4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl trans-3-hydroxypyrrolidine-1-carboxylate2.35 4-((4-(3-(tert-Butyl)-1H-pyrazol-1-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl trans-3-hydroxyazetidine-1-carboxylate2.36 4-((6-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate2.37 4-((6-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)((4-(4-methoxy-3,5-dimethylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate2.38 (1r,4r)-4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl (1-oxidotetrahydro-2H-thiopyran-4-yl)carbamate2.39 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl trans-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)carbamate3 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate3.01 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl (tetrahydro-2H-pyran-4-yl)trans-carbamate3.02 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)(trans(4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-(hydroxymethyl)azetidine-1-carboxylate3.03 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxypyrrolidine-1-carboxylate3.04 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3,5-dimethylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate3.05 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(6-methoxy-5-methylpyridin-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate3.06 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(6-(dimethylamino)pyridin-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate3.07 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl trans-3-hydroxyazetidine-1-carboxylate3.08 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-(hydroxymethyl)azetidine-1-carboxylate3.09 4-((4-(2-(tert-Butyl)thiazol-5-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl (tetrahydro-2H-pyran-4-yl)trans-carbamate3.10 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl 3-hydroxyazetidine-trans-1-carboxylate3.11 4-((4-(2-(tert-Butyl)oxazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl (tetrahydro-2H-pyran-4-yl)trans-carbamate3.12 4-((6-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyrazin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate3.13 4-((6-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyrazin-2-yl)((4-(4-methoxy-3,5-dimethylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate3.14 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyrimidin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate3.15 4-((4-(1-(tert-Butyl)-1H-pyrazol-4-yl)pyrimidin-2-yl)((4-(4-methoxy-3,5-dimethylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)(trans-cyclohexyl) 3-hydroxyazetidine-1-carboxylate4 4-(((4-(4-Methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)(4-(1-(tert-pentyl)-1H-pyrazol-4-yl)pyridin-2-yl)carbamoyl)cyclohexyl trans-3-hydroxyazetidine-1-carboxylate4.01 4-(((4-(4-Methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)(4-(1-(tert-pentyl)-1H-pyrazol-4-yl)pyridin-2-yl)carbamoyl)cyclohexyl trans-3-hydroxy-3-methylazetidine-1-carboxylate4.02 4-(((4-(4-Methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)(4-(1-(tert-pentyl)-1H-pyrazol-4-yl)pyridin-2-yl)carbamoyl)cyclohexyl trans-4-hydroxypiperidine-1-carboxylate4.03 4-(((4-(4-Methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)(4-(1-(tert-pentyl)-1H-pyrazol-4-yl)pyridin-2-yl)carbamoyl)cyclohexyl trans-(3-hydroxypropyl)carbamate4.04 4-(((4-(4-Methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)(4-(1-(3-methylpentan-3-yl)-1H-pyrazol-4-yl)pyridin-2-yl)carbamoyl)cyclohexyl trans-3-hydroxyazetidine-1-carboxylate4.05 4-(((4-(4-Methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)(4-(1-(3-methylpentan-3-yl)-1H-pyrazol-4-yl)pyridin-2-yl)carbamoyl)cyclohexyl trans-3-hydroxy-3-methylazetidine-1-carboxylate4.06 4-(((4-(4-Methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)(4-(1-(3-methylpentan-3-yl)-1H-pyrazol-4-yl)pyridin-2-yl)carbamoyl)cyclohexyl trans-4-hydroxypiperidine-1-carboxylate4.07 4-(((4-(4-Methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)(4-(1-(3-methylpentan-3-yl)-1H-pyrazol-4-yl)pyridin-2-yl)carbamoyl)cyclohexyl trans-(3-hydroxypropyl)carbamate4.08 4-((4-(1-(3-Ethylpentan-3-yl)-1H-pyrazol-4-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl trans-3-hydroxyazetidine-1-carboxylate4.09 4-(((4-(4-Methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)(4-(1-(1,1, 1-trifluoro-2-methylpropan-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)carbamoyl)cyclohexyl trans-3-hydroxyazetidine-1-carboxylate4.10 4-((4-(1-(tert-Butyl)-1H-pyrazol-3-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl trans-3-hydroxyazetidine-1-carboxylate4.11 4-((4-(4-(tert-Butyl)-1H-imidazol-1-yl)pyridin-2-yl)((4-(4-methoxy-3-methylphenyl)bicyclo[2.2.2]octan-1-yl)methyl)carbamoyl)cyclohexyl trans-3-hydroxyazetidine-1-carboxylate

[0192] In some embodiments, provided herein is a pharmaceutically acceptable salt or solvate of a compound that is described in Table 1.

[0193] In one aspect, compounds described herein are in the form of pharmaceutically acceptable salts. As well, active metabolites of these compounds having the same type of activity are included in the scope of the present disclosure. In addition, the compounds described herein can exist in unsolvated as well as solvated forms with pharmaceutically acceptable solvents such as water, ethanol, and the like. The solvated forms of the compounds presented herein are also considered to be disclosed herein.

[0194] "Pharmaceutically acceptable," as used herein, refers a material, such as a carrier or diluent, which does not abrogate the biological activity or properties of the compound, and is relatively nontoxic, i.e., the material is administered to an individual without causing undesirable biological effects or interacting in a deleterious manner with any of the components of the composition in which it is contained.

[0195] The term "pharmaceutically acceptable salt" refers to a form of a therapeutically active agent that consists of a cationic form of the therapeutically active agent in combination with a suitable anion, or in alternative embodiments, an anionic form of the therapeutically active agent in combination with a suitable cation. Handbook of Pharmaceutical Salts: Properties, Selection and Use. International Union of Pure and Applied Chemistry, Wiley-VCH 2002. S.M. Berge, L.D. Bighley, D.C. Monkhouse, J. Pharm. Sci. 1977, 66, 1-19. P. H. Stahl and C. G. Wermuth, editors, Handbook of Pharmaceutical Salts: Properties, Selection and Use, Weinheim / Zürich: Wiley-VCH / VHCA, 2002. Pharmaceutical salts typically are more soluble and more rapidly soluble in stomach and intestinal juices than nonionic species and so are useful in solid dosage forms. Furthermore, because their solubility often is a function of pH, selective dissolution in one or another part of the digestive tract is possible, and this capability can be manipulated as one aspect of delayed and sustained release behaviors. Also, because the salt-forming molecule can be in equilibrium with a neutral form, passage through biological membranes can be adjusted.

[0196] In some embodiments, pharmaceutically acceptable salts are obtained by reacting a compound described herein with an acid to provide a "pharmaceutically acceptable acid addition salt." In some embodiments, the compound described herein (i.e. free base form) is basic and is reacted with an organic acid or an inorganic acid. Inorganic acids include, but are not limited to, hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, nitric acid, and metaphosphoric acid. Organic acids include, but are not limited to, 1-hydroxy-2-naphthoic acid; 2,2-dichloroacetic acid; 2-hydroxyethanesulfonic acid; 2-oxoglutaric acid; 4-acetamidobenzoic acid; 4-aminosalicylic acid; acetic acid; adipic acid; ascorbic acid (L); aspartic acid (L); benzenesulfonic acid; benzoic acid; camphoric acid (+); camphor-10-sulfonic acid (+); capric acid (decanoic acid); caproic acid (hexanoic acid); caprylic acid (octanoic acid); carbonic acid; cinnamic acid; citric acid; cyclamic acid; dodecylsulfuric acid; ethane-1,2-disulfonic acid; ethanesulfonic acid; formic acid; fumaric acid; galactaric acid; gentisic acid; glucoheptonic acid (D); gluconic acid (D); glucuronic acid (D); glutamic acid; glutaric acid; glycerophosphoric acid; glycolic acid; hippuric acid; isobutyric acid; lactic acid (DL); lactobionic acid; lauric acid; maleic acid; malic acid (- L); malonic acid; mandelic acid (DL); methanesulfonic acid; monomethyl fumarate, naphthalene-1,5-disulfonic acid; naphthalene-2-sulfonic acid; nicotinic acid; oleic acid; oxalic acid; palmitic acid; pamoic acid; phosphoric acid; proprionic acid; pyroglutamic acid (- L); salicylic acid; sebacic acid; stearic acid; succinic acid; sulfuric acid; tartaric acid (+ L); thiocyanic acid; toluenesulfonic acid (p); and undecylenic acid.

[0197] In some embodiments, a compound described herein is prepared as a chloride salt, sulfate salt, bromide salt, mesylate salt, maleate salt, citrate salt or phosphate salt.

[0198] In some embodiments, pharmaceutically acceptable salts are obtained by reacting a compound described herein with a base to provide a "pharmaceutically acceptable base addition salt."

[0199] In some embodiments, the compound described herein is acidic and is reacted with a base. In such situations, an acidic proton of the compound described herein is replaced by a metal ion, e.g., lithium, sodium, potassium, magnesium, calcium, or an aluminum ion. In some cases, compounds described herein coordinate with an organic base, such as, but not limited to, ethanolamine, diethanolamine, triethanolamine, tromethamine, meglumine, N-methylglucamine, dicyclohexylamine, tris(hydroxymethyl)methylamine. In other cases, compounds described herein form salts with amino acids such as, but not limited to, arginine, lysine, and the like. Acceptable inorganic bases used to form salts with compounds that include an acidic proton, include, but are not limited to, aluminum hydroxide, calcium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium hydroxide, lithium hydroxide, and the like. In some embodiments, the compounds provided herein are prepared as a sodium salt, calcium salt, potassium salt, magnesium salt, meglumine salt, N-methylglucamine salt or ammonium salt.

[0200] It should be understood that a reference to a pharmaceutically acceptable salt includes the solvent addition forms. In some embodiments, solvates contain either stoichiometric or non-stoichiometric amounts of a solvent, and are formed during the process of isolating or purifying the compound with pharmaceutically acceptable solvents such as water, ethanol, and the like. Hydrates are formed when the solvent is water, or alcoholates are formed when the solvent is alcohol. Solvates of compounds described herein are conveniently prepared or formed during the processes described herein. In addition, the compounds provided herein optionally exist in unsolvated as well as solvated forms.

[0201] The methods and formulations described herein include the use of N-oxides (if appropriate), crystalline forms (also known as polymorphs), or pharmaceutically acceptable salts of compounds described herein, as well as active metabolites of these compounds having the same type of activity.

[0202] In some embodiments, sites on the organic groups (e.g., alkyl groups, aromatic rings) of compounds described herein are susceptible to various metabolic reactions. Incorporation of appropriate substituents on the organic groups will reduce, minimize or eliminate this metabolic pathway. In specific embodiments, the appropriate substituent to decrease or eliminate the susceptibility of the aromatic ring to metabolic reactions is, by way of example only, a halogen, deuterium, an alkyl group, a haloalkyl group, or a deuteroalkyl group.

[0203] In another embodiment, the compounds described herein are labeled isotopically (e.g., with a radioisotope) or by another other means, including, but not limited to, the use of chromophores or fluorescent moieties, bioluminescent labels, or chemiluminescent labels.

[0204] Compounds described herein include isotopically-labeled compounds, which are identical to those recited in the various formulae and structures presented herein, but for the fact that one or more atoms are replaced by an atom having an atomic mass or mass number different from the atomic mass or mass number usually found in nature. Examples of isotopes that can be incorporated into the present compounds include isotopes of hydrogen, carbon, nitrogen, oxygen, fluorine and chlorine, such as, for example, 2< H, 3< H, 13< C, 14< C, 15< N, 18< O, 17< O, 35< S, 18< F, 36< Cl. In one aspect, isotopically-labeled compounds described herein, for example those into which radioactive isotopes such as 3< H and 14< C are incorporated, are useful in drug and / or substrate tissue distribution assays. In one aspect, substitution with isotopes such as deuterium affords certain therapeutic advantages resulting from greater metabolic stability, such as, for example, increased in vivo half-life or reduced dosage requirements. In some embodiments, one or more hydrogen atoms of the compounds described herein is replaced with deuterium.

[0205] In some embodiments, the compounds described herein possess one or more stereocenters and each stereocenter exists independently in either the R or S configuration. The compounds presented herein include all diastereomeric, enantiomeric, atropisomers, and epimeric forms as well as the appropriate mixtures thereof. The compounds and methods provided herein include all cis, trans, syn, anti, entgegen (E), and zusammen (Z) isomers as well as the appropriate mixtures thereof.

[0206] Individual stereoisomers are obtained, if desired, by methods such as, stereoselective synthesis and / or the separation of stereoisomers by chiral chromatographic columns. In certain embodiments, compounds described herein are prepared as their individual stereoisomers by reacting a racemic mixture of the compound with an optically active resolving agent to form a pair of diastereoisomeric compounds / salts, separating the diastereomers and recovering the optically pure enantiomers. In some embodiments, resolution of enantiomers is carried out using covalent diastereomeric derivatives of the compounds described herein. In another embodiment, diastereomers are separated by separation / resolution techniques based upon differences in solubility. In other embodiments, separation of steroisomers is performed by chromatography or by the forming diastereomeric salts and separation by recrystallization, or chromatography, or any combination thereof. Jean Jacques, Andre Collet, Samuel H. Wilen, "Enantiomers, Racemates and Resolutions", John Wiley and Sons, Inc., 1981. In some embodiments, stereoisomers are obtained by stereoselective synthesis.

[0207] In some embodiments, compounds described herein are prepared as prodrugs. A "prodrug" refers to an agent that is converted into the parent drug in vivo. Prodrugs are often useful because, in some situations, they are easier to administer than the parent drug. They are, for instance, bioavailable by oral administration whereas the parent is not. The prodrug may be a substrate for a transporter. Further or alternatively, the prodrug also has improved solubility in pharmaceutical compositions over the parent drug. In some embodiments, the design of a prodrug increases the effective water solubility. An example, without limitation, of a prodrug is a compound described herein, which is administered as an ester (the "prodrug") but then is metabolically hydrolyzed to provide the active entity. A further example of a prodrug is a short peptide (polyaminoacid) bonded to an acid group where the peptide is metabolized to reveal the active moiety. In certain embodiments, upon in vivo administration, a prodrug is chemically converted to the biologically, pharmaceutically, or therapeutically active form of the compound. In certain embodiments, a prodrug is enzymatically metabolized by one or more steps or processes to the biologically, pharmaceutically or therapeutically active form of the compound.

[0208] Prodrugs of the compounds described herein include, but are not limited to, esters, ethers, carbonates, thiocarbonates, N-acyl derivatives, N-acyloxyalkyl derivatives, quaternary derivatives of tertiary amines, N-Mannich bases, Schiff bases, amino acid conjugates, phosphate esters, and sulfonate esters. See for example Design of Prodrugs, Bundgaard, A. Ed., Elseview, 1985 and Method in Enzymology, Widder, K. et al., Ed.; Academic, 1985, vol. 42, p. 309-396; Bundgaard, H. "Design and Application of Prodrugs" in A Textbook of Drug Design and Development, Krosgaard-Larsen and H. Bundgaard, Ed., 1991, Chapter 5, p. 113-191; and Bundgaard, H., Advanced Drug Delivery Review, 1992, 8, 1-38, each of which is incorporated herein by reference. In some embodiments, a hydroxyl group in the compounds disclosed herein is used to form a prodrug, wherein the hydroxyl group is incorporated into an acyloxyalkyl ester, alkoxycarbonyloxyalkyl ester, alkyl ester, aryl ester, phosphate ester, sugar ester, ether, and the like. In some embodiments, a hydroxyl group in the compounds disclosed herein is a prodrug wherein the hydroxyl is then metabolized in vivo to provide a carboxylic acid group. In some embodiments, a carboxyl group is used to provide an ester or amide (i.e. the prodrug), which is then metabolized in vivo to provide a carboxylic acid group. In some embodiments, compounds described herein are prepared as alkyl ester prodrugs.

[0209] Prodrug forms of the herein described compounds, wherein the prodrug is metabolized in vivo to produce a compound described herein as set forth herein are included within the scope of the claims. In some cases, some of the herein-described compounds is a prodrug for another derivative or active compound. In some embodiments, a prodrug of the compound disclosed herein permits targeted delivery of the compound to a particular region of the gastrointestinal tract. Formation of a pharmacologically active metabolite by the colonic metabolism of drugs is a commonly used "prodrug" approach for the colon-specific drug delivery systems.

[0210] In some embodiments, a prodrug is formed by the formation of a covalent linkage between drug and a carrier in such a manner that upon oral administration the moiety remains intact in the stomach and small intestine. This approach involves the formation of a prodrug, which is a pharmacologically inactive derivative of a parent drug molecule that requires spontaneous or enzymatic transformation in the biological environment to release the active drug. Formation of prodrugs has improved delivery properties over the parent drug molecule. The problem of stability of certain drugs from the adverse environment of the upper gastrointestinal tract can be eliminated by prodrug formation, which is converted into the parent drug molecule once it reaches the colon. Site specific drug delivery through site specific prodrug activation may be accomplished by the utilization of some specific property at the target site, such as altered pH or high activity of certain enzymes relative to the non-target tissues for the prodrug-drug conversion.

[0211] In some embodiments, covalent linkage of the drug with a carrier forms a conjugate. Such conjugates include, but are not limited to, azo bond conjugates, glycoside conjugates, glucuronide conjugates, cyclodextrin conjugates, dextran conjugates or amino-acid conjugates.

[0212] In additional or further embodiments, the compounds described herein are metabolized upon administration to an organism in need to produce a metabolite that is then used to produce a desired effect, including a desired therapeutic effect.

[0213] A "metabolite" of a compound disclosed herein is a derivative of that compound that is formed when the compound is metabolized. The term "active metabolite" refers to a biologically active derivative of a compound that is formed when the compound is metabolized. The term "metabolized," as used herein, refers to the sum of the processes (including, but not limited to, hydrolysis reactions and reactions catalyzed by enzymes) by which a particular substance is changed by an organism. Thus, enzymes may produce specific structural alterations to a compound. For example, cytochrome P450 catalyzes a variety of oxidative and reductive reactions while uridine diphosphate glucuronyltransferases catalyze the transfer of an activated glucuronic-acid molecule to aromatic alcohols, aliphatic alcohols, carboxylic acids, amines and free sulphydryl groups. Metabolites of the compounds disclosed herein are optionally identified either by administration of compounds to a host and analysis of tissue samples from the host, or by incubation of compounds with hepatic cells in vitro and analysis of the resulting compounds.

[0214] In some embodiments, the compounds described herein are rapidly metabolized following absorption from the gastro-intestinal tract to metabolites that have greatly reduced FXR agonist activity.

[0215] In additional or further embodiments, the compounds are rapidly metabolized in plasma.

[0216] In additional or further embodiments, the compounds are rapidly metabolized by the intestines.

[0217] In additional or further embodiments, the compounds are rapidly metabolized by the liver.Synthesis of Compounds

[0218] Compounds described herein are synthesized using standard synthetic techniques or using methods known in the art in combination with methods described herein.

[0219] Unless otherwise indicated, conventional methods of mass spectroscopy, NMR, HPLC, protein chemistry, biochemistry, recombinant DNA techniques and pharmacology are employed.

[0220] Compounds are prepared using standard organic chemistry techniques such as those described in, for example, March's Advanced Organic Chemistry, 6th Edition, John Wiley and Sons, Inc. Alternative reaction conditions for the synthetic transformations described herein may be employed such as variation of solvent, reaction temperature, reaction time, as well as different chemical reagents and other reaction conditions. The starting materials are available from commercial sources or are readily prepared.

[0221] Suitable reference books and treatise that detail the synthesis of reactants useful in the preparation of compounds described herein, or provide references to articles that describe the preparation, include for example, "Synthetic Organic Chemistry", John Wiley & Sons, Inc., New York; S. R. Sandler et al., "Organic Functional Group Preparations," 2nd Ed., Academic Press, New York, 1983; H. O. House, "Modern Synthetic Reactions", 2nd Ed., W. A. Benjamin, Inc. Menlo Park, Calif. 1972; T. L. Gilchrist, "Heterocyclic Chemistry", 2nd Ed., John Wiley & Sons, New York, 1992; J. March, "Advanced Organic Chemistry: Reactions, Mechanisms and Structure", 4th Ed., Wiley-Interscience, New York, 1992. Additional suitable reference books and treatise that detail the synthesis of reactants useful in the preparation of compounds described herein, or provide references to articles that describe the preparation, include for example, Fuhrhop, J. and Penzlin G. "Organic Synthesis: Concepts, Methods, Starting Materials", Second, Revised and Enlarged Edition (1994) John Wiley & Sons ISBN: 3-527-29074-5; Hoffman, R.V. "Organic Chemistry, An Intermediate Text" (1996) Oxford University Press, ISBN 0-19-509618-5; Larock, R. C. "Comprehensive Organic Transformations: A Guide to Functional Group Preparations" 2nd Edition (1999) Wiley-VCH, ISBN: 0-471-19031-4; March, J. "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure" 4th Edition (1992) John Wiley & Sons, ISBN: 0-471-60180-2; Otera, J. (editor) "Modern Carbonyl Chemistry" (2000) Wiley-VCH, ISBN: 3-527-29871-1; Patai, S. "Patai's 1992 Guide to the Chemistry of Functional Groups" (1992) Interscience ISBN: 0-471-93022-9; Solomons, T. W. G. "Organic Chemistry" 7th Edition (2000) John Wiley & Sons, ISBN: 0-471-19095-0; Stowell, J.C., "Intermediate Organic Chemistry" 2nd Edition (1993) Wiley-Interscience, ISBN: 0-471-57456-2; "Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopedia" (1999) John Wiley & Sons, ISBN: 3-527-29645-X, in 8 volumes; "Organic Reactions" (1942-2000) John Wiley & Sons, in over 55 volumes; and "Chemistry of Functional Groups" John Wiley & Sons, in 73 volumes.

[0222] The compounds described herein are prepared by the general synthetic routes described below in Schemes 1 to 11.

[0223] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 1.

[0224] In Scheme 1, X 1< , X 5< , X 6< , and X 7< are as described herein. In some embodiments, X is CH or N. In some embodiments, X is CH. In some embodiments, X is N. In some embodiments, R is an alkyl group. In some embodiments, R is hydrogen. In some embodiments, R is independently an alkyl group or hydrogen. In some embodiments, the alkyl groups bonded to the same boron atom, through the respective oxygen atoms on the same boron atom, are an alkylene group bridging the two oxygen atoms on the same boron atom. In some embodiments, the boron atom, the two oxygen atoms on the same boron atom, and the carbon atoms of the alkylene group that bridge the two oxygen atoms form a five- or six-member ring. In some embodiments, the bridging alkylene group is -C(CH 3 ) 2 C(CH 3 ) 2 - and is part of a five-member ring.

[0225] In some embodiments, heteroaryl I-1 is reacted under suitable S N 1 conditions to provide heteroaryl halide I-2 . In some embodiments, suitable S N 1 conditions include reacting I-1 with tBuOH and an appropriate acid at the appropriate temperature for the appropriate time. In some embodiments, the appropriate acid is a strong acid. In some embodiments, the strong acid is sulfuric acid, hydrochloric acid, or hydrobromic acid. In some embodiments, the strong acid is sulfuric acid. In some embodiments, the strong acid is concentrated sulfuric acid. In some embodiments, the appropriate time is from about 1 hour to about 12-18 hours, where the range of time from about 12-18 hours is referred to, interchangeably herein, as "overnight". In some embodiments, the appropriate temperature is from about 60 °C to about 110 °C. In some embodiments, the appropriate temperature is about 80 °C to about 90 °C.

[0226] In some embodiments, boron reagent I-3 is reacted with a heteroaryl halide I-2 under suitable metal-catalyzed cross-coupling reaction conditions to provide I-4 . In some embodiments, the boron reagent is an aryl boronic acid. In some embodiments, the boron reagent is an aryl boronic ester. In some embodiments, the boron reagent is a substituted pyridineboronic acid. In some embodiments, the heteroaryl halide is a pyrazolyl bromide. In some embodiments, the heteroaryl halide is a 3-bromopyrazole. In some embodiments, the heteroaryl halide is a 4-bromopyrazole. In some embodiments, suitable metal-catalyzed cross-coupling reaction conditions include palladium. In some embodiments, suitable metal-catalyzed cross-coupling reaction conditions include palladium, an appropriate base, and an appropriate solvent for an appropriate time and at an appropriate temperature. In some embodiments, the palladium is delivered in the form of Pd(dppf)Cl 2 . In some embodiments, the appropriate base is an inorganic base. In some embodiments, the inorganic base is a carbonate, a phosphate, an oxide, or a hydroxide. In some embodiments, the inorganic base is an alkali metal inorganic base. In some embodiments, the alkali metal is sodium, potassium, cesium, or combinations thereof. In some embodiments, the inorganic base is Na 2 CO 3 , K 2 CO 3 , Cs 2 CO 3 , or combinations thereof. In some embodiments, the combination is a combination of Na 2 CO 3 and K 2 CO 3 . In some embodiments, the inorganic base is K 2 CO 3 . In some embodiments, the inorganic base is Cs 2 CO 3 . In some embodiments, the appropriate solvent is an aqueous solvent. In some embodiments, the appropriate solvent is a mixture of water and an organic solvent. In some embodiments, the organic solvent in the mixture is a C 1-4 -alcohol, THF, 2-MeTHF, DMF, dioxane, or a combination thereof. In some embodiments, the organic solvent in the mixture is dioxane. In some embodiments, the appropriate time is from about 1 hour to about 12-18 hours. In some embodiments, the appropriate temperature is from about 50 °C to about 115 °C. In some embodiments, the appropriate temperature is about 80 °C. In some embodiments, the reaction is performed in a microwave. In some embodiments, the appropriate time is from about 10 minutes to about 30 minutes. In some embodiments, the appropriate temperature is from about 130 °C to about 170 °C. In some embodiments, the appropriate temperature is about 150 °C to about 160 °C.

[0227] In some embodiments, aryl halide I-5 is reacted with boron reagent I-6 under suitable metal-catalyzed cross-coupling reaction conditions to provide I-4 . In some embodiments, the aryl halide is an aryl bromide. In some embodiments, the aryl halide is a substituted pyridyl halide. In some embodiments, the aryl halide is a substituted pyridyl bromide. In some embodiments, the aryl halide is a substituted 4-bromopyridine. In some embodiments, the boron reagent is a heteroaryl boronic acid. In some embodiments, the boron reagent is a heteroaryl boronic ester. In some embodiments, the boron reagent is a heteroaryl pinacolyl boronic ester. In some embodiments, the heteroaryl boron reagent is a pyrazolyl boron reagent. In some embodiments, suitable metal-catalyzed cross-coupling reaction conditions include palladium. In some embodiments, suitable metal-catalyzed cross-coupling reaction conditions include palladium, an appropriate base, and an appropriate solvent for an appropriate time and at an appropriate temperature. In some embodiments, the palladium is delivered in the form of Pd(dppf)Cl 2 . In some embodiments, the appropriate base is an inorganic base. In some embodiments, the inorganic base is a carbonate, a phosphate, an oxide, or a hydroxide. In some embodiments, the inorganic base is an alkali metal inorganic base. In some embodiments, the alkali metal is sodium, potassium, cesium, or combinations thereof. In some embodiments, the inorganic base is Na 2 CO 3 , K 2 CO 3 , Cs 2 CO 3 , or combinations thereof. In some embodiments, the combination is a combination of Na 2 CO 3 and K 2 CO 3 . In some embodiments, the inorganic base is K 2 CO 3 . In some embodiments, the inorganic base is Cs 2 CO 3 . In some embodiments, the appropriate solvent is an aqueous solvent. In some embodiments, the appropriate solvent is a mixture of water and an organic solvent. In some embodiments, the organic solvent in the mixture is a C 1-4 -alcohol, THF, 2-MeTHF, DME, DMF, dioxane, or a combination thereof. In some embodiments, the organic solvent in the mixture is dioxane. In some embodiments, the organic solvent in the mixture is 2-MeTHF. In some embodiments, the organic solvent in the mixture is DME. In some embodiments, the appropriate time and appropriate temperature are from about 2 hours to overnight and about 90 °C. In some embodiments, the reaction is performed in a microwave. In some embodiments, the appropriate time is from about 10 minutes to about 30 minutes. In some embodiments, the appropriate temperature is from about 130 °C to about 170 °C. In some embodiments, the appropriate temperature is about 150 °C to about 160 °C.

[0228] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 2.

[0229] In Scheme 2, X is C-H or N. In some embodiments, the 5-membered heterocycle of II-2 is pyrazolyl, pyrrolyl, imidazolyl, or triazolyl. In some embodiments, R is NHBoc, iodide, bromide, chloride, or trifluoromethanesulfonate (triflate, -OTf, CF 3 SO 3 -). In some embodiments, R is NHBoc. In some embodiments, R is bromide or chloride. In some embodiments, R is chloride.

[0230] In some embodiments, aryl fluoride II-1 is reacted with heteroaryl II-2 under suitable S N Ar reaction conditions to provide II-3 . In some embodiments, heteroaryl II-2 is reacted with aryl fluoride II-1 where R is chloro. In some embodiments, heteroaryl II-2 is reacted with aryl fluoride II-1 where R is NHBoc. In some embodiments, suitable S N Ar reaction conditions include an appropriate base and an appropriate solvent, for an appropriate time at an appropriate temperature. In some embodiments, the appropriate base is an inorganic base. In some embodiments, the inorganic base is a carbonate base. In some embodiments, the carbonate base is an alkali metal carbonate. In some embodiments, the alkali metal carbonate is K 2 CO 3 . In some embodiments, the appropriate solvent is DMSO, NMP, toluene, or combinations thereof. In some embodiments, the appropriate solvent is a mixture of water and DMSO, NMP, toluene, or combinations thereof. In some embodiments, the appropriate solvent is NMP. In some embodiments, the appropriate time and appropriate temperature are overnight and about 100 °C.

[0231] In some embodiments, II-3 is subjected to suitable palladium-catalyzed cross coupling reaction conditions in the presence of a suitable ammonia source to provide II-4 . In some embodiments, II-3 , wherein R is halo, is subjected to suitable palladium-catalyzed cross coupling reaction conditions in the presence of a suitable ammonia source to provide II-4. In some embodiments, II-3 , wherein R is bromo or chloro, is subjected to suitable palladium-catalyzed cross coupling reaction conditions in the presence of a suitable ammonia source to provide II-4 . In some embodiments, II-3 , wherein R is chloro, is subjected to suitable palladium-catalyzed cross coupling reaction conditions in the presence of a suitable ammonia source to provide II-4. In some embodiments, the suitable ammonia source is LiHMDS. In some embodiments, suitable palladium-catalyzed cross-coupling reaction conditions include tris(dibenzylideneacetone)dipalladium(0), an appropriate ligand, and an appropriate solvent for an appropriate time at an appropriate temperature. In some embodiments, the appropriate ligand is 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl. In some embodiments, the appropriate solvent is dioxane or THF. In some embodiments, the appropriate time and appropriate temperature are from about 2 hours to overnight and about 100 °C. In some embodiments, the appropriate time and appropriate temperature are overnight and about 60 °C.

[0232] In some embodiments, the suitable hydrolysis reaction conditions are sufficient to deprotect the tert-butyloxycarbonyl-protected aniline II-3 and provide II-4 . In some embodiments, the suitable hydrolysis reaction conditions are sufficient to deprotect the tert-butyloxycarbonyl-protected aniline II-3 , wherein R is NHBoc, and provide II-4 . In some embodiments, the suitable hydrolysis conditions include an appropriate acid and an appropriate solvent, for an appropriate time at an appropriate temperature. In some embodiments, the appropriate acid is aqueous HCl. In some embodiments, the appropriate solvent is methanol. In some embodiments, the appropriate solvent is EtOAc. In some embodiments, the appropriate acid is HCl in EtOAc. In some embodiments, the appropriate time and appropriate temperature are about overnight and 50 °C.

[0233] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 3.

[0234] In Scheme 3, X 1< and R 8< are as described herein. In some embodiments, R is an alkyl group. In some embodiments, R is hydrogen. In some embodiments, R is independently an alkyl group or hydrogen. In some embodiments, the alkyl groups bonded to the same boron atom, through the respective oxygen atoms on the same boron atom, are an alkylene group bridging the two oxygen atoms on the same boron atom. In some embodiments, the boron atom, the two oxygen atoms on the same boron atom, and the carbon atoms of the alkylene group that bridge the two oxygen atoms form a five- or six-member ring. In some embodiments, the bridging alkylene group is -C(CH 3 ) 2 C(CH 3 ) 2 - and is part of a five-member ring.

[0235] In some embodiments, thioamide III-1 is reacted with bromoacetaldehyde dimethyl acetal (2-bromo-1,1-dimethoxyethane) under suitable condensation reaction conditions followed by suitable bromination reaction conditions to provide 2-substituted bromothiazole III-2 . In some embodiments, the suitable condensation reaction conditions are sufficient to provide an intermediate 2-substituted thiazole that provides 2-substituted bromothiazole III-2 after bromination under suitable bromination reaction conditions. In some embodiments, suitable condensation reaction conditions include an appropriate acid catalyst and an appropriate solvent, for an appropriate time at an appropriate temperature. In some embodiments, the appropriate acid is para-toluenesulfonic acid. In some embodiments, the appropriate solvent is acetic acid. In some embodiments, the appropriate time and appropriate temperature are overnight and about 120 °C. In some embodiments, the suitable bromination reaction conditions are sufficient to brominate the intermediate 2-substituted thiazole and provide III-2 . In some embodiments, the suitable bromination conditions include an appropriate brominating agent and an appropriate solvent, for an appropriate time at an appropriate temperature. In some embodiments, the appropriate brominating agent is NBS. In some embodiments, the appropriate solvent is DMF. In some embodiments, the appropriate time and appropriate temperature are about 1 hour and room temperature.

[0236] In some embodiments, boron reagent III-3 is reacted with a 2-substituted bromothiazole III-2 under suitable metal-catalyzed cross-coupling reaction conditions to provide III-4 . In some embodiments, the 2-substituted bromothiazole is a 5-bromo-2-substituted thiazole. In some embodiments, suitable metal-catalyzed cross-coupling reaction conditions include palladium. In some embodiments, suitable metal-catalyzed cross-coupling reaction conditions include palladium, an appropriate base, and an appropriate solvent for an appropriate time and at an appropriate temperature. In some embodiments, the palladium is delivered in the form of Pd(dppf)Cl 2 . In some embodiments, the appropriate base is an inorganic base. In some embodiments, the inorganic base is carbonate, a phosphate, an oxide, or a hydroxide. In some embodiments, the inorganic base is an alkali metal inorganic base. In some embodiments, the alkali metal is sodium, potassium, cesium, or combinations thereof. In some embodiments, the inorganic base is Na 2 CO 3 , K 2 CO 3 , Cs 2 CO 3 , or combinations thereof. In some embodiments, the combination is a combination of Na 2 CO 3 and K 2 CO 3 . In some embodiments, the inorganic base is K 2 CO 3 . In some embodiments, the inorganic base is Cs 2 CO 3 . In some embodiments, the appropriate solvent is an aqueous solvent. In some embodiments, the appropriate solvent is a mixture of water and an organic solvent. In some embodiments, the organic solvent in the mixture is a C 1-4 -alcohol, THF, DMF, dioxane, or a combination thereof. In some embodiments, the organic solvent in the mixture is dioxane. In some embodiments, the appropriate time and appropriate temperature are overnight and about 80 °C.

[0237] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 4.

[0238] In some embodiments, pyridine carboxylic acid IV-1 is converted to methyl ketone IV-2. In some embodiments, IV-1 is converted to IV-2 using a sequence of reactions referred to alternatively as the Weinreb ketone synthesis. In some embodiments, IV-1 is reacted under a series of suitable reaction conditions to provide IV-2. In some embodiments, the series includes suitable carboxylic acid activation reaction conditions, suitable Weinreb amide-forming reaction conditions, and suitable alkylation reaction conditions, applied in that sequence. In some embodiments, the carboxylic acid activation reaction conditions include an appropriate carboxylic acid activating agent and a solvent, for an appropriate time and at an appropriate temperature. In some embodiments, the carboxylic acid activating agent is carbonyldiimidazole. In some embodiments, the solvent is DCE or DCM. In some embodiments, the time and temperature are from 15 minutes to 60 minutes and room temperature. In some embodiments, the Weinreb amide-forming reaction conditions include an acid salt of N,O-dimethylhydroxylamine and an appropriate solvent, for an appropriate time at an appropriate temperature. In some embodiments, the acid salt of N,O-dimethylhyroxylamine is the hydrochloride salt. In some embodiments, the solvent is the same as included in the carboxylic acid activation reaction conditions. In some embodiments, the time and temperature are overnight and room temperature. In some embodiments, the alkylation reaction conditions include an appropriate alkyl organometallic reagent and a solvent, for an appropriate time and at an appropriate temperature. In some embodiments, the alkyl organometallic reagent is CH 3 MgBr, CH 3 MgCl, CH 3 MgI, (CH 3 ) 2 Mg, or CH 3 Li. In some embodiments, the alkyl organometallic reagent is CH 3 MgBr. In some embodiments, the solvent is THF, Et 2 O, or combinations thereof. In some embodiments, the solvent is THF. In some embodiments, the time and temperature are overnight and from 0 °C to room temperature. In some embodiments, an initial temperature is maintained for a first time, after which the temperature is allowed to warm to a second temperature for second time. In some embodiments, the initial temperature is about 0 °C, the first time is from 15 minutes to 60 minutes, the second temperature is room temperature, and the second time is overnight.

[0239] In some embodiments, α-bromoketone IV-3 is obtained by subjecting ketone IV-2 to suitable bromination conditions. In some embodiments, suitable bromination conditions include bromine, HBr, and acetic acid for a suitable time at a suitable temperature. In some embodiments, the suitable time is overnight. In some embodiments, the suitable temperature is about room temperature.

[0240] In some embodiments, α-haloketone IV-3 is treated with amide IV-4 and an appropriate silver salt, in an appropriate solvent for an appropriate time at an appropriate temperature to provide IV-5. In some embodiments, the silver salt is AgOTf, AgBF 4 , AgClO 4 , or AgSbF 6 . In some embodiments, the silver salt is AgSbF 6 . In some embodiments, the silver salt is AgOTf. In some embodiments, the solvent is EtOAc, dioxane, or DCE. In some embodiments, the time is overnight. In some embodiments, the temperature is from about 50 °C to about 100 °C. In some embodiments, the temperature is about 70 °C or about 100 °C.

[0241] In some embodiments, IV-5 is subjected to suitable palladium-catalyzed cross coupling reaction conditions in the presence of a suitable ammonia source to provide IV-6. In some embodiments, the suitable ammonia source is LiHMDS. In some embodiments, suitable palladium-catalyzed cross-coupling reaction conditions include tris(dibenzylideneacetone)dipalladium(0), an appropriate ligand, and an appropriate solvent for an appropriate time at an appropriate temperature. In some embodiments, the appropriate ligand is 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl. In some embodiments, the appropriate solvent is dioxane or THF. In some embodiments, the appropriate time and appropriate temperature are from about 2 hours to overnight and about 100 °C. In some embodiments, the appropriate time and appropriate temperature are overnight and about 60 °C.

[0242] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 5.

[0243] In some embodiments, R" is an alcohol protecting group. In some embodiments, the alcohol protecting group is methyl, a substituted methyl group, a substituted ethyl group, a substituted benzyl group, or a silyl group, as described in, for example, Wuts, P. G. M. "Greene's Protective Groups in Organic Synthesis" (2014) John Wiley & Sons ISBN: 978-1-118-05748-3. In some embodiments, the alcohol protecting group is a silyl group. In some embodiments, the silyl group is tert-butyldimethylsilyl.

[0244] In some embodiments, V-1 is subjected to suitable alcohol protection reaction conditions to form a bis-silyl intermediate, followed by suitable hydrolysis reaction conditions to form V-2, in the case where R" is a silyl group. In some embodiments, R" is tert-butyldimethylsilyl and the alcohol protection reaction conditions include a tert-butyldimethylsilyl halide and an appropriate base, in an appropriate solvent for an appropriate time at an appropriate temperature. In some embodiments, the tert-butyldimethylsilyl halide is tert-butyldimethylsilyl chloride. In some embodiments, the base is imidazole. In some embodiments, the solvent is DMF. In some embodiments, the time is about 2 hours and the temperature is about room temperature. In some embodiments, the bis-silyl intermediate (a silyl ester) is subjected to suitable hydrolysis reaction conditions to form V-2. In some embodiments, the suitable hydrolysis reaction conditions include a base, in an appropriate solvent, for an appropriate time, at an appropriate temperature. In some embodiments, the base is K 2 CO 3 . In some embodiments, the solvent is a mixture of water, ethanol, and THF. In some embodiments, the solvent is aqueous ethanol, aqueous THF, or combinations thereof. In some embodiments, the time is about 3 hours and the temperature is about room temperature.

[0245] In some embodiments, when R" is methyl, a substituted methyl group, a substituted ethyl group, or a substituted benzyl group, V-1 is subjected to suitable alcohol protection reaction conditions to form a bis-alkyl intermediate (where both the carboxylic acid and alcohol -OH are alkylated, to form an ester and ether, respectively, and, for the purposes of Scheme 5, and schemes referencing Scheme 5 or schemes referencing intermediates or products disclosed in Scheme 5, the alkyl groups on the bis-alkyl intermediate are methyl, a substituted methyl group, a substituted ethyl group, or a substituted benzyl group), followed by suitable hydrolysis reaction conditions to form V-2.

[0246] In some embodiments, protected alcohol V-2 is converted to acid chloride V-3, under suitable chlorination reaction conditions. In some embodiments, the chlorination reaction conditions include (chloromethylene)dimethyliminium chloride and an appropriate base, in an appropriate solvent for an appropriate time at an appropriate temperature. In some embodiments, the base is anhydrous K 2 CO 3 . In some embodiments, the solvent is toluene. In some embodiments, the time is from about 0.5 hr to about 2 hours. In some embodiments, the temperature is about 0 °C. In some embodiments, the temperature is room temperature.

[0247] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 6.

[0248] In Scheme 6, X 2< and R 1< are as described herein. In some embodiments, X is a halide. In some embodiments, the halide is chloride, bromide or iodide. In some embodiments, the halide is bromide. In some embodiments, R is -CO 2 R' or -CN. In some embodiments, R' is -C 1-6 alkyl. In some embodiments, R' is -CH 3 , -C(CH 3 ) 3 , or -CH 2 CH 3 . In some embodiments, R' is -CH 2 CH 3 .

[0249] In some embodiments, halide VI-1 is cooled to a suitable temperature, reacted under suitable metal-halogen exchange conditions with an appropriate solvent for an appropriate time and at an appropriate temperature, and then later reacted with an appropriate ketone VI-2 for an appropriate time and at an appropriate temperature to provide a tertiary alcohol. In some embodiments, suitable metal-halogen exchange conditions include an organometallic reagent. In some embodiments, the appropriate solvent is THF. In some embodiments, the organometallic reagent is an alkyllithium. In some embodiments, the alkyllithium is n-butyllithium. In some embodiments, VI-1 is cooled to about -78 °C before addition of the organometallic reagent. In some embodiments, VI-1 is reacted for about one hour at about - 78 °C before addition of ketone VI-2. In some embodiments, VI-1 is reacted for about 2 hours after the addition of ketone VI-2. In some embodiments, the appropriate temperature for reacting VI-1 and ketone VI-2 is about -78 °C. In some embodiments, the tertiary alcohol is reacted under appropriate allylation conditions which include use of an allylating reagent and a Lewis acid, in an appropriate solvent for an appropriate time and at an appropriate temperature to form VI-3. In some embodiments, the appropriate allylating reagent is allyltrimethylsilane. In some embodiments, the appropriate Lewis acid is BF 3 -OEt 2 . In some embodiments, the appropriate solvent is DCM. In some embodiments, the appropriate temperature for the appropriate time is about -78 °C for about 1 hour. In some embodiments, the reaction is further warmed to about room temperature overnight. In some embodiments, the appropriate temperature for the appropriate time is about 0 °C for overnight.

[0250] In some embodiments, halide VI-1 is cooled to a suitable temperature, reacted under suitable metal-halogen exchange conditions with an appropriate solvent for an appropriate time and at an appropriate temperature, and then later reacted with an appropriate ketone VI-4 for an appropriate time and at an appropriate temperature to provide a tertiary alcohol. In some embodiments, suitable metal-halogen exchange conditions include an organometallic reagent. In some embodiments, the appropriate solvent is THF. In some embodiments, the organometallic reagent is an alkyllithium. In some embodiments, the alkyllithium is n-butyllithium. In some embodiments, VI-1 is cooled to about -60 °C before addition of the organometallic reagent. In some embodiments, VI-4 is added slowly for about 45 minutes at about -60 °C. In some embodiments, VI-1 is reacted for about 1 hour at -60 °C after complete addition of ketone VI-4. In some embodiments, the appropriate temperature for reacting VI-1 and ketone VI-4 is about -60 °C. In some embodiments, the tertiary alcohol is reacted under appropriate allylation conditions which include use of an allylating reagent and a Lewis acid, in an appropriate solvent for an appropriate time and at an appropriate temperature to form VI-5. In some embodiments, the appropriate allylating reagent is allyltrimethylsilane. In some embodiments, the appropriate Lewis acid is BF 3 -OEt 2 . In some embodiments, the appropriate solvent is DCM. In some embodiments, the appropriate temperature for the appropriate time is about -65 °C for about 1 hour.

[0251] In some embodiments, VI-5 is reaction under 1,3-dioxalane deprotection conditions for an appropriate time period, in an appropriate solvent, and at an appropriate temperature, followed by reductive cyanation of the resulting ketone-intermediate for an appropriate time period, in an appropriate solvent, and at an appropriate temperature to produce VI-6. In some embodiments, 1,3-dioxalane deprotection conditions include the use an appropriate acid. In some embodiments, the appropriate acid is formic acid. In some embodiments, the appropriate solvent is a THF / water mixture. In some embodiments, the appropriate temperature for the appropriate time is from about 40 °C to about 65 °C overnight. In some embodiments, the resulting ketone is reacted under the appropriate reductive cyanation conditions for an appropriate time period, in an appropriate solvent, and at an appropriate temperature to form VI-6. In some embodiments, the appropriate reductive cyanation conditions include the use of the appropriate cyanation reagent and an appropriate base. In some embodiments, the appropriate cyanation reagent is an appropriate isocyanide. In some embodiments, the appropriate isocyanide is toluenesulfonylmethyl isocyanide (Tos-MIC). In some embodiments, the appropriate base is a strong, non-nucleophilic base. In some embodiments, the strong, non-nucleophilic base is t-BuOK. In some embodiments, the appropriate solvent is DME. In some embodiments, the ketone intermediate and the appropriate cyanation reagent is cooled to about 0 to 5 °C before addition of the appropriate base. In some embodiments, appropriate base is added slowly over about 1 hour at about 0 to 5 °C. In some embodiments, the reductive cyanation reaction takes place for about 1 hour at 25 °C after complete addition of the base. In some embodiments, the reductive cyanation reaction takes place for about 2 hours at 25 °C after complete addition of the base. In some embodiments, the appropriate temperature for the reductive cyanation reaction is about 25 °C.

[0252] In some embodiments, VI-3 or VI-6 are reacted under suitable oxidative cleavage conditions for an appropriate time period, in an appropriate solvent, and at an appropriate temperature to produce VI-7. In some embodiments, oxidative cleavage conditions include the use of an osmium reagent and N-methylmorpholine N-oxide to form an intermediate diol. In some embodiments, the osmium reagent is OsO 4 or K 2 OsO 4 -2H 2 O. In some embodiments, the appropriate solvent is an ACN / water mixture. In some embodiments, the appropriate solvent is an acetone / water mixture. In some embodiments, the appropriate temperature for the appropriate time is from about 0 °C to about room temperature for overnight. In some embodiments, the appropriate temperature for the appropriate time is from about 0 °C to about room temperature for 2 hours. In some embodiments, the appropriate temperature for the appropriate time is about room temperature for 2 hours. In some embodiments, the diol is cleaved to form VI-7 under the appropriate oxidative cleavage conditions for an appropriate time period, in an appropriate solvent, and at an appropriate temperature. In some embodiments, appropriate oxidative cleavage conditions include the use of NaIO 4 . In some embodiments, the appropriate solvent is a THF / water mixture. In some embodiments, the NaIO 4 is added to the diol intermediate over about 0.5 hours at about 0-5 °C. In some embodiments, the appropriate temperature for the appropriate time after complete addition of NaIO 4 is from about 0 °C to about room temperature for 3 hours. In some embodiments, the appropriate temperature for the appropriate time after complete addition of NaIO 4 is about room temperature for 3 hours.

[0253] In some embodiments, VI-7 is reduced to a primary alcohol under suitable reducing conditions, and then halogenated under suitable halogenation conditions to produce VI-8. In some embodiments, suitable reducing conditions include the use of a borohydride reagent. In some embodiments, the reducing conditions include the use of NaBH 4 in an appropriate solvent, at an appropriate temperature for an appropriate amount of time. In some embodiments, the appropriate solvent is THF. In some embodiments, the appropriate temperature for the appropriate time is about 0 °C for about 1 hour. In some embodiments, the reaction is warmed to about room temperature for about 3 hours. In some embodiments, the primary alcohol is reacted under suitable halogenation conditions to produce an alkyl halide. In some embodiments, suitable halogenation conditions are bromination conditions that include use of CBr 4 in an appropriate solvent at an appropriate initial temperature followed by PPh 3 in the appropriate solvent, at an appropriate temperature for an appropriate time. In some embodiments, the appropriate solvent is a halogenated solvent, such as DCM. In some embodiments, the appropriate initial temperature is about 0 °C. In some embodiments, the appropriate initial temperature is about 0 °C and PPh 3 is slowly added over about 1 hour. In some embodiments, the appropriate temperature and time after complete addition of PPh 3 is about 25 °C for about 1.5 hour. In some embodiments, an appropriate solvent for addition of PPh 3 is THF. In some embodiments, the reaction is further warmed to about room temperature for overnight.

[0254] In some embodiments, VI-8 is subjected to intramolecular alkylation conditions to form VI-9. In some embodiments, intramolecular alkylation conditions include a suitable base in an appropriate solvent at an appropriate temperature for an appropriate amount of time. In some embodiments, the suitable base is lithium diisopropylamide. In some embodiments, the appropriate solvent is a HMPA and THF mixture. In some embodiments, the suitable base is slowly added over 1 hour at about -65 °C. In some embodiments, the appropriate temperature for the appropriate amount of time after complete addition of the appropriate base is about -65 °C for about 3 hours.

[0255] In some embodiments, when R is -CN, VI-9 is reduced to aldehyde VI-10 by suitable reduction conditions. In some embodiments, when R is -CO 2 Et, VI-9 is reduced by suitable reduction conditions followed by oxidation to aldehyde VI-10 by suitable oxidation conditions. In some embodiments, suitable reduction conditions include the use of DIBALH in an appropriate solvent at an appropriate temperature for an appropriate time. In some embodiments, the appropriate solvent is toluene. In some embodiments, DIBALH is added at appropriate temperature for the appropriate time. In some embodiments, DIBALH is slowly added over 1 hour at about -65 °C. In some embodiments, the appropriate temperature for the appropriate time after the complete addition of DIBALH is about -65 °C for about 1 hour. In some embodiments, suitable oxidation conditions are chromium-based oxidations. In some embodiments, suitable oxidation conditions include the use of PCC in an appropriate solvent at an appropriate temperature for an appropriate time. In some embodiments, silica gel is added. In some embodiments, the appropriate solvent is DCM. In some embodiments, the appropriate temperature is about room temperature for about 2 hours. Alternatively, in some embodiments, the oxidation conditions include the use of oxalyl chloride and DMSO with an amine base in an appropriate solvent at an appropriate temperature for an appropriate time. In some embodiments, the appropriate amine base is TEA. In some embodiments, the appropriate solvent is DCM. In some embodiments, the appropriate temperature for the appropriate amount of time is about -78 °C for about 1 hour.

[0256] In some embodiments, aldehyde VI-10 is transformed into bisulfite adduct VI-11 under suitable conditions. In some embodiments, suitable conditions include the use of the appropriate reagent in an appropriate solvent at an appropriate temperature for an appropriate time. In some embodiments, the appropriate reagent is aqueous potassium metabisulfite. In some embodiments, the appropriate solvent is THF. In some embodiments, the appropriate temperature and time is about 45 °C for about 3.5 hours. In some embodiments, the reaction is further cooled to about room temperature for overnight.

[0257] In some embodiments, bisulfite adduct VI-11 is converted back to aldehyde VI-10 by suitable conditions. In some embodiments, suitable conditions include the use of the appropriate base in an appropriate solvent at an appropriate temperature for an appropriate time. In some embodiments, the appropriate base is a carbonate salt. In some embodiments, the appropriate base is aqueous sodium carbonate. In some embodiments, the appropriate solvent is DCM. In some embodiments, the appropriate temperature and time is about 25 °C for about 1 hour.

[0258] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 7.

[0259] In Scheme 7, X 2< , X 3< , X 4< , R 1< , and R 2< are as described herein. In some embodiments, both X 2< and X 3< are N. In some embodiments, either X 2< or X 3< is N and the other is CR 2< . In some embodiments, both X 2< and X 3< are CR 2< .

[0260] In some embodiments, halide VII-1 is cooled to a suitable temperature and reacted under suitable metal-halogen exchange conditions with an appropriate solvent for an appropriate time and at an appropriate temperature to provide an aryl or heteroaryl magnesium bromide salt VII-2. In some embodiments, suitable metal-halogen exchange conditions include a metal reagent. In some embodiments, the appropriate solvent is THF. In some embodiments, the metal reagent is magnesium. In some embodiments, suitable metal-halogen exchange conditions include a salt. In some embodiments, a suitable salt includes lithium chloride. In some embodiments, suitable metal-halogen exchange conditions include a magnesium activating reagent. In some embodiments, a suitable magnesium activating reagent includes DIBAL-H. In some embodiments, the suitable metal, the suitable salt, and the suitable solvent are combined at 10 °C or room temperature. In some embodiments, magnesium, lithium chloride, and THF are combined at 10 °C. In some embodiments, magnesium, lithium chloride, and THF are combined at room temperature. In some embodiments, DIBAL-H is added to the mixture of the suitable metal, the suitable salt, and the suitable solvent at 10 °C or room temperature, and the reaction is stirred for about 15 minutes. In some embodiments, the temperature is reduced or maintained. In some embodiments, the temperature is reduced to 0 °C. In some embodiments, a solution of VII-1 in THF is added to the reaction. In some embodiments, VII-1 is reacted for about 1 hour to two hours after the addition of VII-1. In some embodiments, VII-1 is reacted for about 1 hour at about 10 °C. In some embodiments, the appropriate temperature for reacting VII-1 is about 25 °C.

[0261] In some embodiments, aryl or heteroaryl magnesium bromide salt VII-2 is reacted under suitable zinc displacement conditions with an appropriate solvent for an appropriate time and at an appropriate temperature to provide a zinc aryl or heteroaryl dimer VII-3. In some embodiments, suitable zinc displacement conditions include a zinc halide salt. In some embodiments, suitable zinc displacement conditions include a zinc chloride. In some embodiments, the appropriate solvent is THF. In some embodiments, VII-2 is reacted for about 1 hour after the addition of the zinc halide salt. In some embodiments, VII-2 is reacted for about 1 hour at about 25 °C after the addition of the zinc halide salt. In some embodiments, the appropriate temperature for reacting VII-2 is about 25 °C.

[0262] In some embodiments, 1,4-endoethylenecyclohexyl carboxylic acid is reacted with N-hydroxyphthalimide under suitable coupling reaction conditions to provide VII-4. In some embodiments, suitable coupling reaction conditions include an appropriate coupling agent, an appropriate base, and an appropriate solvent for an appropriate time and at an appropriate temperature. In some embodiments, the coupling agent is N,N-diisopropylcarbodiimide. In some embodiments, the base is DMAP. In some embodiments, the solvent is DCM or DCE. In some embodiments, the time and the temperature are overnight and room temperature.

[0263] In some embodiments, VII-2 and VII-4 are reacted under suitable aryl-alkyl cross-coupling reaction conditions to provide aryl-alkyl VII-5. In some embodiments, VII-3 and VII-4 are reacted under suitable aryl-alkyl cross-coupling reaction conditions to provide aryl-alkyl VII-5. In some embodiments, VII-4 is reacted under suitable aryl-alkyl cross-coupling reaction conditions to provide aryl-alkyl VII-5. In some embodiments, the suitable aryl-alkyl cross-coupling reaction conditions include nickel. In some embodiments, the suitable aryl-alkyl cross-coupling reaction conditions include nickel when X 2< is -CMe and X 3< is -CMe or when X 2< is -CMe and X 3< is -CH. In some embodiments, the suitable aryl-alkyl cross-coupling reaction conditions include nickel when X 2< is -CMe and X 3< is -CMe. In some embodiments, the suitable aryl-alkyl cross-coupling reaction conditions include nickel when X 2< is -CMe and X 3< is -CH. In some embodiments, suitable aryl-alkyl cross-coupling reaction conditions include an appropriate source of Ni, an appropriate arylzinc or heteroarylzinc reagent, an appropriate auxiliary ligand, and a solvent, for an appropriate time at an appropriate temperature. In some embodiments, the source of Ni is nickel(II) acetylacetonate. In some embodiments, the source of Ni is a Ni(II) halide or a solvate thereof. In some embodiments, the Ni(II) halide is a Ni(II) chloride or Ni(II) bromide In some embodiments, the arylzinc reagent is a substituted phenylzinc reagent. In some embodiments, the substituted phenylzinc reagent is a methoxyphenylzinc reagent. In some embodiments, the methoxyphenylzinc reagent is bis(4-methoxy-3-methylphenyl)zinc or bis(4-methoxy-3,5-dimethylphenyl)zinc . In some embodiments, the heteroarylzinc reagent is a substituted pyridinylzinc reagent. In some embodiments, the substituted pyridinylzinc reagent is a methoxypyridinylzinc reagent. In some embodiments, the methoxypyridinylzinc reagent is bis(6-methoxy-5-methylpyridin-3-yl)zinc. In some embodiments, the auxiliary ligand is 2,2'-bipyridine. In some embodiments, when X 2< is -CMe and X 3< is -CMe, the auxiliary ligand is 2,2'-bipyridine. In some embodiments, the auxiliary ligand is an alkyl-substituted 2,2'-bipyridine. In some embodiments, the alkyl-substituted 2,2'-bipyridine is 6,6'-dimethyl-2,2'-bipyridine or 4,4'-di-tert-butyl-2,2'-bipyridine. In some embodiments, the alkyl-substituted 2,2'-bipyridine is 6,6'-dimethyl-2,2'-bipyridine. In some embodiments, when X 2< is -CMe and X 3< is -CH, the alkyl-substituted 2,2'-bipyridine is 6,6'-dimethyl-2,2'-bipyridine. In some embodiments, the suitable aryl-alkyl cross-coupling reaction conditions include iron. In some embodiments, the suitable aryl-alkyl cross-coupling reaction conditions include iron when X 2< is -CMe and X 3< is N. In some embodiments, the suitable aryl-alkyl cross-coupling reaction conditions include iron when VII-2 is X 2< is -CMe and X 3< is N, and reacted with VII-4. In some embodiments, the solvent is acetonitrile, N,N'-dimethylpropyleneurea (DMPU), DMF, THF or combinations thereof. In some embodiments, the solvent is DMPU. In some embodiments, the time and the temperature are overnight and 25 °C.

[0264] In some embodiments, aryl-alkyl VII-5 is reduced to an alcohol by suitable reduction conditions followed by oxidation to aldehyde VII-6 by suitable oxidation conditions. In some embodiments, suitable reduction conditions include the use of DIBALH in an appropriate solvent at an appropriate temperature for an appropriate time. In some embodiments, the appropriate solvent is DCM. In some embodiments, the appropriate temperature for the appropriate time is about -78 °C for about 1 hour. In some embodiments, the reaction is further warmed to about room temperature for about two hours to produce an alcohol. In some embodiments, suitable oxidation conditions are chromium-based oxidations. In some embodiments, suitable oxidation conditions include the use of PCC in an appropriate solvent at an appropriate temperature for an appropriate time. In some embodiments, silica gel is added. In some embodiments, the appropriate solvent is DCM. In some embodiments, the appropriate temperature is about room temperature for about 2 hours. Alternatively, in some embodiments, the oxidation conditions include the use of oxalyl chloride and DMSO with an amine base in an appropriate solvent at an appropriate temperature for an appropriate time. In some embodiments, the appropriate amine base is TEA. In some embodiments, the appropriate solvent is DCM. In some embodiments, the appropriate temperature for the appropriate amount of time is about -78 °C for about 1 hour.

[0265] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 8.

[0266] In Scheme 8, substituents X 2< , X 3< , X 4< , R 1< , R 2< , and R 3< are as described herein. In some embodiments, X 2< is C-R 2< , X 3< is C-H, and each X 4< is C-H. In some embodiments, X is a halide. In some embodiments, the halide is chloride, bromide, or iodide.

[0267] In some embodiments, boronic ester VIII-2 is reacted with halide VIII-1 under suitable metal-catalyzed cross-coupling reaction conditions to provide VIII-3. In some embodiments, suitable metal-catalyzed cross-coupling conditions include palladium. In some embodiments, suitable metal-catalyzed cross-coupling reaction conditions include palladium, an appropriate base, and an appropriate solvent for an appropriate time and at an appropriate temperature. In some embodiments, the palladium is delivered in the form of Pd(dppf)Cl 2 or Pd(PPh 3 ) 4 . In some embodiments, the appropriate base is an inorganic base. In some embodiments, the inorganic base is a carbonate, a phosphate, an oxide, or a hydroxide. In some embodiments, the inorganic base is an alkali metal inorganic base. In some embodiments, the alkali metal is sodium, potassium, cesium, or combinations thereof. In some embodiments, the inorganic base is Na 2 CO 3 , K 2 CO 3 , Cs 2 CO 3 , or combinations thereof. In some embodiments, the combination is a combination of Na 2 CO 3 and K 2 CO 3 . In some embodiments, the inorganic base is K 2 CO 3 . In some embodiments, the inorganic base is Cs 2 CO 3 . In some embodiments, the appropriate solvent is an aqueous solvent. In some embodiments, the appropriate solvent is a mixture of water and an organic solvent. In some embodiments, the organic solvent in the mixture is a C 1-4 -alcohol, THF, DMF, DME, dioxane, acetonitrile, or a combination thereof. In some embodiments, the organic solvent in the mixture is dioxane. In some embodiments, the appropriate time is from about 1 hour to overnight. In some embodiments, the appropriate temperature is from about 50 °C to about 115 °C. In some embodiments, the appropriate temperature is about 50 °C. In some embodiments, the appropriate temperature is about 100 °C.

[0268] In some embodiments, VIII-3 is subjected to suitable hydrogenation conditions, followed by treatment under appropriate acidic conditions to provide cyclohexanone VIII-4. In some embodiments, suitable hydrogenation conditions include a palladium catalyst. In some embodiments, palladium-catalyzed hydrogenation conditions include 10% Pd / C under an atmosphere including hydrogen gas in an appropriate solvent for an appropriate time at an appropriate temperature. In some embodiments, the hydrogen gas is present in the atmosphere at a partial pressure of about 1 atm. In some embodiments, the solvent is EtOAc, ethanol, methanol, or a combination thereof. In some embodiments, the appropriate time is from about 4.5 hours to overnight and the appropriate temperature is about room temperature. In some embodiments, the acidic conditions include formic acid in a mixture of water and toluene for an appropriate time at an appropriate temperature. In some embodiments, the appropriate time is about 4 hours and the appropriate temperature is about 120 °C. In some embodiments, the appropriate time is overnight and the appropriate temperature is the boiling point of the solvent. In some embodiments, the acidic conditions include PPTS in a mixture of acetone and water for an appropriate time at an appropriate temperature. In some embodiments, the appropriate time is about 10 hours and the appropriate temperature is about 60 °C. In some embodiments, the acidic conditions include 3 M HCl and THF for an appropriate time at an appropriate temperature. In some embodiments, the appropriate time is from about 3 hours to overnight and the appropriate temperature is about 60 °C.

[0269] In some embodiments, VIII-4 is reacted under suitable one carbon-homologation conditions to provide enol ether VIII-5. In some embodiments, suitable one carbon-homologation conditions include deprotonating a phosphonium salt with an appropriate base in an appropriate solvent for an appropriate first time at an appropriate first temperature, before adding the cyclohexanone VIII-4 for a second time at a second temperature. In some embodiments, the phosphonium salt is an alkyltriphenylphosphonium salt. In some embodiments, the alkyltriphenylphosphonium salt is an alkyltriphenylphosphonium chloride. In some embodiments, the alkyltriphenylphosphonium chloride is (methoxymethyl)triphenylphosphonium chloride [Ph 3 P +< CH 2 OCH 3 Cl -< ]. In some embodiments, the appropriate base is LiHMDS, NaHMDS, or KHMDS. In some embodiments, the appropriate base is NaHMDS. In some embodiments, the appropriate solvent is THF. In some embodiments, the appropriate first time is from about 0.5 hour to about 2 hours and the appropriate first temperature is about 0 °C. In some embodiments, the appropriate second time is from about 0.5 hour to about 3 hours and the appropriate second temperature is about 0 °C. In some embodiments, the appropriate second time is overnight and the appropriate second temperature begins at 0 °C and is allowed to increase to about room temperature over the second time.

[0270] In some embodiments, enol ether VIII-5 is hydrolyzed under suitable acidic conditions to provide a mixture of cis- and trans-aldehydes, where the trans-aldehyde is VIII-6. In some embodiments, suitable acidic conditions include an appropriate acid in an appropriate solvent for an appropriate time at an appropriate temperature. In some embodiments, the acid is formic acid, the solvent is a mixture of water and toluene, the time is from about 2 hours to overnight, and the temperature is from about 120 °C to about 130 °C. In some embodiments, the acid is HCl, the solvent is THF, the time is from about 1 hour to about 6 hours, and the temperature is about 60 °C. In some embodiments, treatment of the mixture of cis- and trans-aldehydes under suitable basic conditions provides a mixture further enriched in trans-aldehyde VIII-6. In some embodiments, suitable basic conditions include an appropriate base in an appropriate solvent for an appropriate time at an appropriate temperature. In some embodiments, the base is NaOH. In some embodiments, the solvent is an aqueous solvent mixture including EtOH, toluene, THF, or combinations thereof. In some embodiments, the aqueous solvent mixture includes toluene. In some embodiments, the aqueous solvent mixture includes THF. In some embodiments, the appropriate time is from about 5 hours to overnight and the appropriate temperature is about room temperature. In some embodiments, the base is NaOMe. In some embodiments, the solvent is a C 1-4 alcohol, or mixtures thereof. In some embodiments, the solvent is methanol or ethanol. In some embodiments, the solvent is methanol. In some embodiments, the appropriate time is from 4 hours to overnight and the appropriate temperature is about room temperature. In some embodiments, further purification of the mixture of cis- and trans-aldehydes provides trans-aldehyde VIII-6. In some embodiments, the further purification includes the techniques of crystallization, chromatography, or combinations thereof. In some embodiments, the further purification includes crystallization.

[0271] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 9.

[0272] In Scheme 9, substituents X 2< , X 3< , X 4< , R 1< , R 2< , R 3< , and m are as described herein. In some embodiments, X 2< is C-R 2< , X 3< is C-H, and each X 4< is C-H. In some embodiments, X is a halide. In some embodiments, the halide is chloride, bromide, or iodide.

[0273] In some embodiments, IX-1 is cooled to a suitable temperature, reacted under suitable metal-halogen exchange conditions in an appropriate solvent for an appropriate first time and at an appropriate first temperature, and then later reacted with an appropriate ketone IX-2 for an appropriate second time and at an appropriate second temperature to provide IX-3. In some embodiments, suitable metal-halogen exchange conditions include an organometallic reagent. In some embodiments, the organometallic reagent is an alkyllithium reagent. In some embodiments, the alkylithium reagent is n-butyllithium. In some embodiments, the appropriate solvent is THF. In some embodiments, IX-1 is cooled to about -78 °C before addition of the organometallic reagent. In some embodiments, the first time is from about 1 hour to about 2 hours and the first temperature is about -78 °C. In some embodiments, the second time is about 3 hours and the second temperature is about -78 °C. In some embodiments, the second time is overnight and the second temperature is initially about -78 °C and is allowed to warm to room temperature over the course of the second time.

[0274] In some embodiments, alcohol IX-3 is reacted under suitable reduction conditions to form a mixture of saturated and unsaturated substituted cyclohexyl ketals derived from IX-3. In some embodiments, the suitable reduction conditions include an appropriate reducing agent and an appropriate acid in an appropriate solvent for an appropriate time and at an appropriate temperature. In some embodiments, the reducing agent is a silyl hydride and the acid is trifluoracetic acid. In some embodiments, the silyl hydride is triethylsilane. In some embodiments, the solvent is dichloromethane. In some embodiments, the time is from about 1 hour to overnight. In some embodiments, the temperature is from about 0 °C to about room temperature. In some embodiments, the temperature is about 0 °C. In some embodiments, the mixture of saturated and unsaturated substituted cyclohexyl ketals derived from IX-3 is reacted under suitable hydrolysis reaction conditions to form a mixture of saturated and unsaturated substituted cyclohexyl ketones, including the saturated ketone VIII-4. In some embodiments, the suitable hydrolysis reaction conditions include an appropriate acid in an appropriate solvent for an appropriate time at an appropriate temperature. In some embodiments, the acid is formic acid, the solvent is a toluene / water mixture, the temperature is about 130 °C, and the time is overnight. In some embodiments, the acid is formic acid, the solvent is a THF / water mixture, the temperature is about 80 °C, and the time is overnight. In some embodiments, the mixture of saturated and unsaturated substituted cyclohexyl ketones, including the saturated ketone VIII-4, is reduced under suitable reduction reaction conditions to convert the unsaturated components to VIII-4. In some embodiments, the suitable reduction reaction conditions include an appropriate reducing agent and an appropriate solvent for an appropriate time at an appropriate temperature. In some embodiments, the reducing agent is hydrogen. In some embodiments, the hydrogen is delivered at a pressure of from about 15 psi to about 30 psi. In some embodiments, suitable reduction reaction conditions include a catalyst. In some embodiments, the catalyst includes palladium. In some embodiments, the catalyst including palladium is 10% palladium on carbon. In some embodiments, the solvent is ethyl acetate and concentrated HCl. In some embodiments, the solvent is ethyl acetate. In some embodiments, the time is from about 30 min to about overnight. In some embodiments, the temperature is about room temperature.

[0275] In some embodiments, ketone VIII-4 is transformed into trans-aldehyde VIII-6 under reaction conditions also suitable for conversion of ketone VIII-4 to trans-aldehyde VIII-6, as described in Scheme 8.

[0276] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 10.

[0277] In Scheme 10, Ring A, X 1< , X 2< , X 3< , X 4< , X 5< , X 6< , and X 7< and substituents R 1< , R 2< , and R 8< are as described herein. In some embodiments, the R is a halide or -OH. In some embodiments, the halide is iodo, bromo, or chloro. In some embodiments, the halide is chloro. In some embodiments, R is -OH. In some embodiments, R" is an alcohol protecting group. In some embodiments, the alcohol protecting group is methyl, a substituted methyl group, a substituted ethyl group, a substituted benzyl group, or a silyl group, as described in, for example, Wuts, P. G. M. "Greene's Protective Groups in Organic Synthesis" (2014) John Wiley & Sons ISBN: 978-1-118-05748-3. In some embodiments, the alcohol protecting group is a silyl group. In some embodiments, the silyl group is tert-butyldimethylsilyl.

[0278] In some embodiments, aldehyde VIII-6 (as in Scheme 8 where X 3< and each X 4< are CH, for example) is reacted with aniline X-1 under suitable reductive amination reaction conditions to provide X-2a. In some embodiments, suitable reductive amination reaction conditions include an appropriate reducing agent and an appropriate solvent, at an appropriate temperature for an appropriate time. In some embodiments, the reducing agent is picoline borane, sodium borohydride, or sodium triacetoxyborohydride. In some embodiments, the reducing agent is sodium triacetoxyborohydride. In some embodiments, the solvent is DCM, DCE, THF, acetonitrile, DMF, or N,N-dimethylacetamide. In some embodiments, the solvent is DCM, DCE, or combinations thereof. In some embodiments, the solvent is DCM. In some embodiments, the time is from about 30 minutes to overnight and the temperature is initially about 0 °C and increased to about room temperature over the time. In some embodiments, the temperature is about room temperature.

[0279] In some embodiments, aldehyde VI-10 (as in Scheme 6 where X 3< and each X 4< are CH, for example) is reacted with aniline X-1 under suitable reductive amination reaction conditions to provide X-2b. In some embodiments, suitable reductive amination reaction conditions include optionally an appropriate condensation catalyst, an appropriate reducing agent, and an appropriate solvent, at an appropriate temperature for an appropriate amount of time. In some embodiments, suitable reductive amination reaction conditions include holding VI-10, X-1, and the condensation catalyst in the appropriate solvent at a first temperature for a first amount of time, and subsequently adding the reducing agent and holding the resulting mixture at a second temperature for a second amount of time. In some embodiments, the solvent is an alcohol. In some embodiments, the solvent is methanol. In some embodiments, the condensation catalyst is acetic acid. In some embodiments, the first temperature is from about room temperature to about 60 °C and the first amount of time is about 3 hours to about 68 hours. In some embodiments, the first temperature is about room temperature and the first amount of time is overnight. In some embodiments, the first temperature is about 60 °C and the first amount of time is about 4 hours. In some embodiments, the reducing agent is picoline-BH 3 . In some embodiments, the second temperature is room temperature. In some embodiments, the second temperature is about 40 °C. In some embodiments, the second amount of time is from overnight to about 4 days.

[0280] In some embodiments, suitable reductive amination reaction conditions include the addition of a suitable reducing agent to a mixture of VI-10, X-1, and an appropriate solvent and holding the resulting mixture at an appropriate temperature for an appropriate amount of time. In some embodiments, the reducing agent is sodium triacetoxyborohydride. In some embodiments, 1 equivalent of AcOH is added prior to the reducing agent. In some embodiments, the solvent is DCM or DCE. In some embodiments, the time is about overnight and the temperature is about room temperature. In some embodiments, the temperature is about 45 °C.

[0281] In some embodiments, amine X-2a or X-2b (referred to collectively and alternatively as "X-2" in the disclosure herein relating to Scheme 10) is reacted with cyclohexane X-3 (as in Scheme 10, for example) under suitable acylation reaction conditions followed by suitable hydrolysis reaction conditions to provide X-4, respectively. In some embodiments, the cyclohexane X-3 is an acid chloride or a carboxylic acid. In some embodiments, when X-3 is an acid chloride, the suitable acylation reaction conditions are sufficient to provide an intermediate protected cyclohexyl alcohol that provides X-4 after deprotection under suitable hydrolysis reaction conditions. In some embodiments, X 1< is N or CH, and the acylation reaction conditions include an appropriate base, an appropriate solvent, and optionally DMAP, at an appropriate temperature for an appropriate amount of time. In some embodiments, the base is TEA or pyridine. In some embodiments, the solvent is DCE, DCM, toluene, pyridine, or combinations thereof. In some embodiments, the solvent is DCM. In some embodiments, the solvent is toluene. In some embodiments the temperature is 80 °C and the time is from about 1 hour to overnight. In some embodiments the temperature is room temperature and the time is from 1 hour to overnight. In some embodiments the initial temperature is 0 °C and the reaction is warmed to room temperature, and the time is from about 15 minutes to about 5 hours. In some embodiments, the reaction conditions include DMAP. In some embodiments, X 1< is N, the reaction conditions include DMAP, the base is TEA, the solvent is toluene, the temperature is about 80 °C, and the time is about 1 hour to about 2 hours. In some embodiments, X 1< is N, the reaction conditions include DMAP, the base is pyridine, the solvent is toluene, the temperature is about 80 °C, and the time is from about 1 hour to overnight. In some embodiments, X 1< is CH, the base is TEA, the solvent is toluene, the temperature is about room temperature, and the time is from about 1 hour to about 2 hours. In some embodiments, X 1< is CH, the base is pyridine, the solvent is toluene, the temperature is about room temperature, and the time is from about 1 hour to overnight. In some embodiments, when X-3 is a carboxylic acid, a coupling reagent is used. In some embodiments, the coupling reagent is HATU, EDC, T3P, HBTU, BCTU, or pyBOP. In some embodiments, X-3 is a carboxylic acid, the base is triethylamine, the solvent is DCM, the coupling reagent is T3P, and optionally DMAP, at an appropriate temperature for an appropriate amount of time. In some embodiments, the base is TEA or pyridine. In some embodiments, the solvent is DCE, DCM, toluene, pyridine, or combinations thereof. In some embodiments, the solvent is DCM. In some embodiments the temperature is 40 °C and the time is from about 2 hour to about 63 hours. In some embodiments the temperature is room temperature and the time is from 1 hour to overnight. In some embodiments the initial temperature is 25 °C and the reaction is warmed to 40 °C, and the time is from about 2 hours to about 63 hours. In some embodiments, the reaction conditions include DMAP.

[0282] In some embodiments, the suitable hydrolysis reaction conditions are sufficient to deprotect the intermediate protected cyclohexyl alcohol and provide X-4. In some embodiments, the hydrolysis reaction conditions include an appropriate acid, an appropriate solvent, at an appropriate temperature for an appropriate amount of time. In some embodiments, the acid is aqueous HCl. In some embodiments, the concentration of the aqueous HCl is about 1 M. In some embodiments, the solvent is THF, methanol, or combinations thereof. In some embodiments, the temperature is from about 0 °C to about room temperature and the time is from about 1 hour to about 4 hours. In some embodiments, R" is tert-butyldimethylsilyl, the acid is 1 M HCl, the solvent is a combination of THF and methanol, the temperature is from about 0 °C to about room temperature and the time is from about 1 hour to about 19 hours. In some embodiments, R" is other than tert-butyldimethylsilyl, and the protecting group, R", is removed to provide X-4 according to the corresponding methods, as disclosed, for example, in "Greene's Protective Groups in Organic Synthesis".

[0283] In some embodiments, intermediates used in the preparation of compounds described herein are prepared as outlined in Scheme 11.

[0284] In Scheme 11, ring A and substituents X 1< , X 2< , X 3< , X 4< , X 5< , X 6< , X 7< , R 1< , R 2< , R 3< , R 4< , R 5< , R 6< , R 8< , and m are as described herein. In some embodiments, R is independently alkyl, heteroalkyl, hydroxyalkyl, or hydrogen, or both R are taken together to form a substituted or unsubstituted fused 4-, 5-, or 6-membered ring with 1-3 N atoms and 0-2 O or S atoms in the ring.

[0285] In some embodiments, XI-2 is prepared from XI-1 and an amine, NHR 2 . In some embodiments, XI-1 is subjected to carbonyldiimidazole in an appropriate solvent, such as ACN, at an appropriate temperature, such as at about room temperature to about 80 °C, for an appropriate amount of time to provide an intermediate carbamoyl imidazole. In some embodiments, the appropriate amount of time is from about 2 hours to about 6 hours or about overnight. In some embodiments, the intermediate carbamoyl imidazole is treated with NHR 2 in a suitable solvent, and the reaction is allowed to proceed for an appropriate amount of time at an appropriate temperature. In some embodiments, the suitable solvent is acetonitrile. In some embodiments, the suitable solvent is MeOH, THF, or DCM. In some embodiments, the NHR 2 is added as a solution in MeOH, THF, or DCM. In some embodiments, the NHR 2 is added neat. In some embodiments, the appropriate amount of time at the appropriate temperature is about 15 minutes to overnight at about room temperature. In some embodiments, the appropriate amount of time is about 1 day to about 7 days. In some embodiments, the appropriate temperature is from about room temperature to about 50 °C or from about room temperature to about 100 °C. In some embodiments, the amine, NHR 2 , is delivered as a salt. In some embodiments, the salt is a hydrochloride salt. In some embodiments, when the amine, NHR 2 , is delivered as the hydrochloride salt, then a suitable base, such as iPr 2 NEt, is combined with the intermediate carbonyl imidazole, prior to adding the hydrochloride salt.

[0286] In some embodiments, compounds are prepared as described in the Examples.Certain Terminology

[0287] Unless otherwise stated, the following terms used in this application have the definitions given below. The use of the term "including" as well as other forms, such as "include", "includes," and "included," is not limiting. The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described.

[0288] As used herein, C 1 -C x includes C 1 -C 2 , C 1 -C 3 . . . C 1 -C x . By way of example only, a group designated as "C 1 -C 4 " indicates that there are one to four carbon atoms in the moiety, i.e. groups containing 1 carbon atom, 2 carbon atoms, 3 carbon atoms or 4 carbon atoms. Thus, by way of example only, "C 1 -C 4 alkyl" indicates that there are one to four carbon atoms in the alkyl group, i.e., the alkyl group is selected from among methyl, ethyl, propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, and t-butyl.

[0289] An "alkyl" group refers to an aliphatic hydrocarbon group. The alkyl group is branched or straight chain. In some embodiments, the "alkyl" group has 1 to 10 carbon atoms, i.e. a C 1 -C 10 alkyl. Whenever it appears herein, a numerical range such as "1 to 10" refers to each integer in the given range; e.g., "1 to 10 carbon atoms" means that the alkyl group consist of 1 carbon atom, 2 carbon atoms, 3 carbon atoms, 4 carbon atoms, 5 carbon atoms,6 carbon atoms, etc., up to and including 10 carbon atoms, although the present definition also covers the occurrence of the term "alkyl" where no numerical range is designated. In some embodiments, an alkyl is a C 1 -C 6 alkyl. In one aspect the alkyl is methyl, ethyl, propyl, iso-propyl, n-butyl, iso-butyl, sec-butyl, or t-butyl. Typical alkyl groups include, but are in no way limited to, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tertiary butyl, pentyl, neopentyl, or hexyl.

[0290] An "alkylene" group refers to a divalent alkyl group. Any of the above mentioned monovalent alkyl groups may be an alkylene by abstraction of a second hydrogen atom from the alkyl. In some embodiments, an alkylene is a C 1 -C 6 alkylene. In other embodiments, an alkylene is a C 1 -C 4 alkylene. In certain embodiments, an alkylene comprises one to four carbon atoms (e.g., C 1 -C 4 alkylene). In other embodiments, an alkylene comprises one to three carbon atoms (e.g., C 1 -C 3 alkylene). In other embodiments, an alkylene comprises one to two carbon atoms (e.g., C 1 -C 2 alkylene). In other embodiments, an alkylene comprises one carbon atom (e.g., C 1 alkylene). In other embodiments, an alkylene comprises two carbon atoms (e.g., C 2 alkylene). In other embodiments, an alkylene comprises two to four carbon atoms (e.g., C 2 -C 4 alkylene). Typical alkylene groups include, but are not limited to, -CH 2 -, - CH(CH 3 )-, -C(CH 3 ) 2 -, -CH 2 CH 2 -, -CH 2 CH(CH 3 )-, -CH 2 C(CH 3 ) 2 -, -CH 2 CH 2 CH 2 -, - CH 2 CH 2 CH 2 CH 2 -, and the like.

[0291] "Deuteroalkyl" refers to an alkyl group where 1 or more hydrogen atoms of an alkyl are replaced with deuterium.

[0292] The term "alkenyl" refers to a type of alkyl group in which at least one carbon-carbon double bond is present. In one embodiment, an alkenyl group has the formula - C(R)=CR 2 , wherein R refers to the remaining portions of the alkenyl group, which may be the same or different. In some embodiments, R is H or an alkyl. In some embodiments, an alkenyl is selected from ethenyl (i.e., vinyl), propenyl (i.e., allyl), butenyl, pentenyl, pentadienyl, and the like. Non-limiting examples of an alkenyl group include -CH=CH 2 ,-C(CH 3 )=CH 2 , -CH=CHCH 3 , -C(CH 3 )=CHCH 3 , and -CH 2 CH=CH 2 .

[0293] The term "alkynyl" refers to a type of alkyl group in which at least one carbon-carbon triple bond is present. In one embodiment, an alkenyl group has the formula -C≡C-R, wherein R refers to the remaining portions of the alkynyl group. In some embodiments, R is H or an alkyl. In some embodiments, an alkynyl is selected from ethynyl, propynyl, butynyl, pentynyl, hexynyl, and the like. Non-limiting examples of an alkynyl group include -C≡CH, - C≡CCH 3 -C≡CCH 2 CH 3 , -CH 2 C≡CH.

[0294] An "alkoxy" group refers to a (alkyl)O- group, where alkyl is as defined herein.

[0295] The term "alkylamine" refers to the -N(alkyl) x H y group, where x is 0 and y is 2, or where x is 1 and y is 1, or where x is 2 and y is 0.

[0296] The term "aromatic" refers to a planar ring having a delocalized π-electron system containing 4n+2 π electrons, where n is an integer. The term "aromatic" includes both carbocyclic aryl ("aryl", e.g., phenyl) and heterocyclic aryl (or "heteroaryl" or "heteroaromatic") groups (e.g., pyridine). The term includes monocyclic or fused-ring polycyclic (i.e., rings which share adjacent pairs of carbon or nitrogen atoms) groups.

[0297] The term "carbocyclic" or "carbocycle" refers to a ring or ring system where the atoms forming the backbone of the ring are all carbon atoms. The term thus distinguishes carbocyclic from "heterocyclic" rings or "heterocycles" in which the ring backbone contains at least one atom which is different from carbon. In some embodiments, at least one of the two rings of a bicyclic carbocycle is aromatic. In some embodiments, both rings of a bicyclic carbocycle are aromatic. Carbocycle includes cycloalkyl and aryl.

[0298] As used herein, the term "aryl" refers to an aromatic ring wherein each of the atoms forming the ring is a carbon atom. In one aspect, aryl is phenyl or a naphthyl. In some embodiments, an aryl is a phenyl. In some embodiments, an aryl is a C 6 -C 10 aryl. Depending on the structure, an aryl group is a monoradical or a diradical (i.e., an arylene group).

[0299] The term "cycloalkyl" refers to a monocyclic or polycyclic aliphatic, non-aromatic group, wherein each of the atoms forming the ring (i.e. skeletal atoms) is a carbon atom. In some embodiments, cycloalkyls are spirocyclic or bridged compounds. In some embodiments, cycloalkyls are optionally fused with an aromatic ring, and the point of attachment is at a carbon that is not an aromatic ring carbon atom. Cycloalkyl groups include groups having from 3 to 10 ring atoms. In some embodiments, cycloalkyl groups are selected from among cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, spiro[2.2]pentyl, norbornyl and bicyclo[1.1.1]pentyl. In some embodiments, a cycloalkyl is a C 3 -C 6 cycloalkyl. In some embodiments, a cycloalkyl is a monocyclic cycloalkyl. Monocyclic cycloalkyls include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and cyclooctyl. Polycyclic cycloalkyls include, for example, adamantyl, norbornyl (i.e., bicyclo[2.2.1]heptanyl), norbornenyl, decalinyl, 7,7-dimethyl-bicyclo[2.2.1]heptanyl, and the like

[0300] The term "halo" or, alternatively, "halogen" or "halide" means fluoro, chloro, bromo or iodo. In some embodiments, halo is fluoro, chloro, or bromo.

[0301] The term "haloalkyl" refers to an alkyl in which one or more hydrogen atoms are replaced by a halogen atom. In one aspect, a fluoroalkyl is a C 1 -C 6 fluoroalkyl.

[0302] The term "fluoroalkyl" refers to an alkyl in which one or more hydrogen atoms are replaced by a fluorine atom. In one aspect, a fluoroalkyl is a C 1 -C 6 fluoroalkyl. In some embodiments, a fluoroalkyl is selected from trifluoromethyl, difluoromethyl, fluoromethyl, 2,2,2-trifluoroethyl, 1-fluoromethyl-2-fluoroethyl, and the like.

[0303] The term "heteroalkyl" refers to an alkyl group in which one or more skeletal atoms of the alkyl are selected from an atom other than carbon, e.g., oxygen, nitrogen (e.g., -NH-, - N(alkyl)-, sulfur, or combinations thereof. A heteroalkyl is attached to the rest of the molecule at a carbon atom of the heteroalkyl. In one aspect, a heteroalkyl is a C 1 -C 6 heteroalkyl.

[0304] The term "heteroalkylene" refers to a divalent heteroalkyl group.

[0305] The term "heterocycle" or "heterocyclic" refers to heteroaromatic rings (also known as heteroaryls) and heterocycloalkyl rings (also known as heteroalicyclic groups) containing one to four heteroatoms in the ring(s), where each heteroatom in the ring(s) is selected from O, S and N, wherein each heterocyclic group has from 3 to 10 atoms in its ring system, and with the proviso that any ring does not contain two adjacent O or S atoms. In some embodiments, heterocycles are monocyclic, bicyclic, polycyclic, spirocyclic or bridged compounds. Non-aromatic heterocyclic groups (also known as heterocycloalkyls) include rings having 3 to 10 atoms in its ring system and aromatic heterocyclic groups include rings having 5 to 10 atoms in its ring system. The heterocyclic groups include benzo-fused ring systems. Examples of non-aromatic heterocyclic groups are pyrrolidinyl, tetrahydrofuranyl, dihydrofuranyl, tetrahydrothienyl, oxazolidinonyl, tetrahydropyranyl, dihydropyranyl, tetrahydrothiopyranyl, piperidinyl, morpholinyl, thiomorpholinyl, thioxanyl, piperazinyl, aziridinyl, azetidinyl, oxetanyl, thietanyl, homopiperidinyl, oxepanyl, thiepanyl, oxazepinyl, diazepinyl, thiazepinyl, 1,2,3,6-tetrahydropyridinyl, pyrrolin-2-yl, pyrrolin-3-yl, indolinyl, 2H-pyranyl, 4H-pyranyl, dioxanyl, 1,3-dioxolanyl, pyrazolinyl, dithianyl, dithiolanyl, dihydropyranyl, dihydrothienyl, dihydrofuranyl, pyrazolidinyl, imidazolinyl, imidazolidinyl, 3-azabicyclo[3.1.0]hexanyl, 3-azabicyclo[4.1.0]heptanyl, 3H-indolyl, indolin-2-onyl, isoindolin-1-onyl, isoindoline-1,3-dionyl, 3,4-dihydroisoquinolin-1(2H)-onyl, 3,4-dihydroquinolin-2(1H)-onyl, isoindoline-1,3-dithionyl, benzo[d]oxazol-2(3H)-onyl, 1H-benzo[d]imidazol-2(3H)-onyl, benzo[d]thiazol-2(3H)-onyl, and quinolizinyl. Examples of aromatic heterocyclic groups are pyridinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, tetrazolyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, quinolinyl, isoquinolinyl, indolyl, benzimidazolyl, benzofuranyl, cinnolinyl, indazolyl, indolizinyl, phthalazinyl, pyridazinyl, triazinyl, isoindolyl, pteridinyl, purinyl, oxadiazolyl, thiadiazolyl, furazanyl, benzofurazanyl, benzothiophenyl, benzothiazolyl, benzoxazolyl, quinazolinyl, quinoxalinyl, naphthyridinyl, and furopyridinyl. The foregoing groups are either C-attached (or C-linked) or N-attached where such is possible. For instance, a group derived from pyrrole includes both pyrrol-1-yl (N-attached) or pyrrol-3-yl (C-attached). Further, a group derived from imidazole includes imidazol-1-yl or imidazol-3-yl (both N-attached) or imidazol-2-yl, imidazol-4-yl or imidazol-5-yl (all C-attached). The heterocyclic groups include benzo-fused ring systems. Non-aromatic heterocycles are optionally substituted with one or two oxo (=O) moieties, such as pyrrolidin-2-one. In some embodiments, at least one of the two rings of a bicyclic heterocycle is aromatic. In some embodiments, both rings of a bicyclic heterocycle are aromatic.

[0306] The terms "heteroaryl" or, alternatively, "heteroaromatic" refers to an aryl group that includes one or more ring heteroatoms selected from nitrogen, oxygen and sulfur. Illustrative examples of heteroaryl groups include monocyclic heteroaryls and bicyclic heteroaryls. Monocyclic heteroaryls include pyridinyl, imidazolyl, pyrimidinyl, pyrazolyl, triazolyl, pyrazinyl, tetrazolyl, furyl, thienyl, isoxazolyl, thiazolyl, oxazolyl, isothiazolyl, pyrrolyl, pyridazinyl, triazinyl, oxadiazolyl, thiadiazolyl, and furazanyl. Bicyclic heteroaryls include indolizine, indole, benzofuran, benzothiophene, indazole, benzimidazole, purine, quinolizine, quinoline, isoquinoline, cinnoline, phthalazine, quinazoline, quinoxaline, 1,8-naphthyridine, and pteridine. In some embodiments, a heteroaryl contains 0-4 N atoms in the ring. In some embodiments, a heteroaryl contains 1-4 N atoms in the ring. In some embodiments, a heteroaryl contains 0-4 N atoms, 0-1 O atoms, and 0-1 S atoms in the ring. In some embodiments, a heteroaryl contains 1-4 N atoms, 0-1 O atoms, and 0-1 S atoms in the ring. In some embodiments, heteroaryl is a C 1 -C 9 heteroaryl. In some embodiments, monocyclic heteroaryl is a C 1 -C 5 heteroaryl. In some embodiments, monocyclic heteroaryl is a 5-membered or 6-membered heteroaryl. In some embodiments, bicyclic heteroaryl is a C 6 -C 9 heteroaryl.

[0307] A "heterocycloalkyl" or "heteroalicyclic" group refers to a cycloalkyl group that includes at least one heteroatom selected from nitrogen, oxygen and sulfur. In some embodiments, a heterocycloalkyl is fused with an aryl or heteroaryl. In some embodiments, the heterocycloalkyl is oxazolidinonyl, pyrrolidinyl, tetrahydrofuranyl, tetrahydrothienyl, tetrahydropyranyl, tetrahydrothiopyranyl, piperidinyl, morpholinyl, thiomorpholinyl, piperazinyl, piperidin-2-onyl, pyrrolidine-2,5-dithionyl, pyrrolidine-2,5-dionyl, pyrrolidinonyl, imidazolidinyl, imidazolidin-2-onyl, or thiazolidin-2-onyl. The term heteroalicyclic also includes all ring forms of the carbohydrates, including but not limited to the monosaccharides, the disaccharides and the oligosaccharides. In one aspect, a heterocycloalkyl is a C 2 -C 10 heterocycloalkyl. In another aspect, a heterocycloalkyl is a C 4 -C 10 heterocycloalkyl. In some embodiments, a heterocycloalkyl contains 0-2 N atoms in the ring. In some embodiments, a heterocycloalkyl contains 0-2 N atoms, 0-2 O atoms and 0-1 S atoms in the ring.

[0308] The term "bond" or "single bond" refers to a chemical bond between two atoms, or two moieties when the atoms joined by the bond are considered to be part of larger substructure. In one aspect, when a group described herein is a bond, the referenced group is absent thereby allowing a bond to be formed between the remaining identified groups.

[0309] The term "moiety" refers to a specific segment or functional group of a molecule. Chemical moieties are often recognized chemical entities embedded in or appended to a molecule.

[0310] The term "optionally substituted" or "substituted" means that the referenced group is optionally substituted with one or more additional group(s). In some other embodiments, optional substituents are individually and independently selected from D, halogen, -CN, - NH 2 , -NH(alkyl), -N(alkyl) 2 , -OH, -CO 2 H, -CO 2 alkyl, -C(=O)NH 2 , -C(=O)NH(alkyl), - C(=O)N(alkyl) 2 , -S(=O) 2 NH 2 , -S(=O) 2 NH(alkyl), -S(=O) 2 N(alkyl) 2 , -CH 2 CO 2 H, - CH 2 CO 2 alkyl, -CH 2 C(=O)NH 2 , -CH 2 C(=O)NH(alkyl), -CH 2 C(=O)N(alkyl) 2 , - CH 2 S(=O) 2 NH 2 , - CH 2 S(=O) 2 NH(alkyl), - CH 2 S(=O) 2 N(alkyl) 2 , alkyl, alkenyl, alkynyl, cycloalkyl, fluoroalkyl, heteroalkyl, alkoxy, fluoroalkoxy, heterocycloalkyl, aryl, heteroaryl, aryloxy, alkylthio, arylthio, alkylsulfoxide, arylsulfoxide, alkylsulfone, and arylsulfone. The term "optionally substituted" or "substituted" means that the referenced group is optionally substituted with one or more additional group(s) individually and independently selected from D, halogen, -CN, -NH 2 , -NH(alkyl), -N(alkyl) 2 , -OH, -CO 2 H, -CO 2 alkyl, -C(=O)NH 2 , - C(=O)NH(alkyl), -C(=O)N(alkyl) 2 , -S(=O) 2 NH 2 , -S(=O) 2 NH(alkyl), -S(=O) 2 N(alkyl) 2 , alkyl, cycloalkyl, fluoroalkyl, heteroalkyl, alkoxy, fluoroalkoxy, heterocycloalkyl, aryl, heteroaryl, aryloxy, alkylthio, arylthio, alkylsulfoxide, arylsulfoxide, alkylsulfone, and arylsulfone. In some other embodiments, optional substituents are independently selected from D, halogen, - CN, -NH 2 , -NH(CH 3 ), -N(CH 3 ) 2 , -OH, -CO 2 H, -CO 2 (C 1 -C 4 alkyl), -C(=O)NH 2 , - C(=O)NH(C 1 -C 4 alkyl), -C(=O)N(C 1 -C 4 alkyl) 2 , -S(=O) 2 NH 2 , -S(=O) 2 NH(C 1 -C 4 alkyl), - S(=O) 2 N(C 1 -C 4 alkyl) 2 , C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl, C 1 -C 4 fluoroalkyl, C 1 -C 4 heteroalkyl, C 1 -C 4 alkoxy, C 1 -C 4 fluoroalkoxy, -SC 1 -C 4 alkyl, -S(=O)C 1 -C 4 alkyl, and -S(=O) 2 C 1 -C 4 alkyl. In some embodiments, optional substituents are independently selected from D, halogen, -CN, - NH 2 , -OH, -NH(CH 3 ), -N(CH 3 ) 2 , -CH 3 , -CH 2 CH 3 , -CF 3 , -OCH 3 , and -OCF 3 . In some embodiments, substituted groups are substituted with one or two of the preceding groups. In some embodiments, substituted groups are substituted with one of the preceding groups. In some embodiments, an optional substituent on an aliphatic carbon atom (acyclic or cyclic) includes oxo (=O).

[0311] The term "acceptable" with respect to a formulation, composition or ingredient, as used herein, means having no persistent detrimental effect on the general health of the subject being treated.

[0312] The term "modulate" as used herein, means to interact with a target either directly or indirectly so as to alter the activity of the target, including, by way of example only, to enhance the activity of the target, to inhibit the activity of the target, to limit the activity of the target, or to extend the activity of the target.

[0313] The term "modulator" as used herein, refers to a molecule that interacts with a target either directly or indirectly. The interactions include, but are not limited to, the interactions of an agonist, partial agonist, an inverse agonist, antagonist, degrader, or combinations thereof. In some embodiments, a modulator is an agonist.

[0314] The terms "administer," "administering", "administration," and the like, as used herein, refer to the methods that may be used to enable delivery of compounds or compositions to the desired site of biological action. These methods include, but are not limited to oral routes, intraduodenal routes, parenteral injection (including intravenous, subcutaneous, intraperitoneal, intramuscular, intravascular or infusion), topical and rectal administration. Those of skill in the art are familiar with administration techniques that can be employed with the compounds and methods described herein. In some embodiments, the compounds and compositions described herein are administered orally.

[0315] The terms "co-administration" or the like, as used herein, are meant to encompass administration of the selected therapeutic agents to a single patient, and are intended to include treatment regimens in which the agents are administered by the same or different route of administration or at the same or different time.

[0316] The terms "effective amount" or "therapeutically effective amount," as used herein, refer to a sufficient amount of an agent or a compound being administered, which will relieve to some extent one or more of the symptoms of the disease or condition being treated. The result includes reduction and / or alleviation of the signs, symptoms, or causes of a disease, or any other desired alteration of a biological system. For example, an "effective amount" for therapeutic uses is the amount of the composition comprising a compound as disclosed herein required to provide a clinically significant decrease in disease symptoms. An appropriate "effective" amount in any individual case is optionally determined using techniques, such as a dose escalation study.

[0317] The terms "enhance" or "enhancing," as used herein, means to increase or prolong either in potency or duration a desired effect. Thus, in regard to enhancing the effect of therapeutic agents, the term "enhancing" refers to the ability to increase or prolong, either in potency or duration, the effect of other therapeutic agents on a system. An "enhancing-effective amount," as used herein, refers to an amount adequate to enhance the effect of another therapeutic agent in a desired system.

[0318] The term "pharmaceutical combination" as used herein, means a product that results from the mixing or combining of more than one active ingredient and includes both fixed and non-fixed combinations of the active ingredients. The term "fixed combination" means that the active ingredients, e.g., a compound described herein, or a pharmaceutically acceptable salt thereof, and a co-agent, are both administered to a patient simultaneously in the form of a single entity or dosage. The term "non-fixed combination" means that the active ingredients, e.g., a compound described herein, or a pharmaceutically acceptable salt thereof, and a co-agent, are administered to a patient as separate entities either simultaneously, concurrently or sequentially with no specific intervening time limits, wherein such administration provides effective levels of the two compounds in the body of the patient. The latter also applies to cocktail therapy, e.g., the administration of three or more active ingredients.

[0319] The terms "kit" and "article of manufacture" are used as synonyms.

[0320] The term "subject" or "patient" encompasses mammals. Examples of mammals include, but are not limited to, any member of the Mammalian class: humans, non-human primates such as chimpanzees, and other apes and monkey species; farm animals such as cattle, horses, sheep, goats, swine; domestic animals such as rabbits, dogs, and cats; laboratory animals including rodents, such as rats, mice and guinea pigs, and the like. In one aspect, the mammal is a human.

[0321] The terms "treat," "treating" or "treatment," as used herein, include alleviating, abating or ameliorating at least one symptom of a disease or condition, preventing additional symptoms, inhibiting the disease or condition, e.g., arresting the development of the disease or condition, relieving the disease or condition, causing regression of the disease or condition, relieving a condition caused by the disease or condition, or stopping the symptoms of the disease or condition either prophylactically and / or therapeutically.Pharmaceutical compositions

[0322] In some embodiments, the compounds described herein are formulated into pharmaceutical compositions. Pharmaceutical compositions are formulated in a conventional manner using one or more pharmaceutically acceptable inactive ingredients that facilitate processing of the active compounds into preparations that are used pharmaceutically. Proper formulation is dependent upon the route of administration chosen. A summary of pharmaceutical compositions described herein is found, for example, in Remington: The Science and Practice of Pharmacy, Nineteenth Ed (Easton, Pa.: Mack Publishing Company, 1995); Hoover, John E., Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pennsylvania 1975; Liberman, H.A. and Lachman, L., Eds., Pharmaceutical Dosage Forms, Marcel Decker, New York, N.Y., 1980; and Pharmaceutical Dosage Forms and Drug Delivery Systems, Seventh Ed. (Lippincott Williams & Wilkins1999), herein incorporated by reference for such disclosure.

[0323] In some embodiments, the compounds described herein are administered either alone or in combination with pharmaceutically acceptable carriers, excipients or diluents, in a pharmaceutical composition. Administration of the compounds and compositions described herein can be affected by any method that enables delivery of the compounds to the site of action. These methods include, though are not limited to delivery via enteral routes (including oral, gastric or duodenal feeding tube, rectal suppository and rectal enema), parenteral routes (injection or infusion, including intraarterial, intracardiac, intradermal, intraduodenal, intramedullary, intramuscular, intraosseous, intraperitoneal, intrathecal, intravascular, intravenous, intravitreal, epidural and subcutaneous), inhalational, transdermal, transmucosal, sublingual, buccal and topical (including epicutaneous, dermal, enema, eye drops, ear drops, intranasal, vaginal) administration, although the most suitable route may depend upon for example the condition and disorder of the recipient. By way of example only, compounds described herein can be administered locally to the area in need of treatment, by for example, local infusion during surgery, topical application such as creams or ointments, injection, catheter, or implant. The administration can also be by direct injection at the site of a diseased tissue or organ.

[0324] In some embodiments, pharmaceutical compositions suitable for oral administration are presented as discrete units such as capsules, cachets or tablets each containing a predetermined amount of the active ingredient; as a powder or granules; as a solution or a suspension in an aqueous liquid or a non-aqueous liquid; or as an oil-in-water liquid emulsion or a water-in-oil liquid emulsion. In some embodiments, the active ingredient is presented as a bolus, electuary or paste.

[0325] Pharmaceutical compositions which can be used orally include tablets, push-fit capsules made of gelatin, as well as soft, sealed capsules made of gelatin and a plasticizer, such as glycerol or sorbitol. Tablets may be made by compression or molding, optionally with one or more accessory ingredients. Compressed tablets may be prepared by compressing in a suitable machine the active ingredient in a free-flowing form such as a powder or granules, optionally mixed with binders, inert diluents, or lubricating, surface active or dispersing agents. Molded tablets may be made by molding in a suitable machine a mixture of the powdered compound moistened with an inert liquid diluent. In some embodiments, the tablets are coated or scored and are formulated so as to provide slow or controlled release of the active ingredient therein. All formulations for oral administration should be in dosages suitable for such administration. The push-fit capsules can contain the active ingredients in admixture with filler such as lactose, binders such as starches, and / or lubricants such as talc or magnesium stearate and, optionally, stabilizers. In soft capsules, the active compounds may be dissolved or suspended in suitable liquids, such as fatty oils, liquid paraffin, or liquid polyethylene glycols. In some embodiments, stabilizers are added. Dragee cores are provided with suitable coatings. For this purpose, concentrated sugar solutions may be used, which may optionally contain gum arabic, talc, polyvinyl pyrrolidone, carbopol gel, polyethylene glycol, and / or titanium dioxide, lacquer solutions, and suitable organic solvents or solvent mixtures. Dyestuffs or pigments may be added to the tablets or Dragee coatings for identification or to characterize different combinations of active compound doses.

[0326] In some embodiments, pharmaceutical compositions are formulated for parenteral administration by injection, e.g., by bolus injection or continuous infusion. Formulations for injection may be presented in unit dosage form, e.g., in ampoules or in multi-dose containers, with an added preservative. The compositions may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilizing and / or dispersing agents. The compositions may be presented in unit-dose or multi-dose containers, for example sealed ampoules and vials, and may be stored in powder form or in a freeze-dried (lyophilized) condition requiring only the addition of the sterile liquid carrier, for example, saline or sterile pyrogen-free water, immediately prior to use. Extemporaneous injection solutions and suspensions may be prepared from sterile powders, granules and tablets of the kind previously described.

[0327] Pharmaceutical compositions for parenteral administration include aqueous and non-aqueous (oily) sterile injection solutions of the active compounds which may contain antioxidants, buffers, bacteriostats and solutes which render the formulation isotonic with the blood of the intended recipient; and aqueous and non-aqueous sterile suspensions which may include suspending agents and thickening agents. Suitable lipophilic solvents or vehicles include fatty oils such as sesame oil, or synthetic fatty acid esters, such as ethyl oleate or triglycerides, or liposomes. Aqueous injection suspensions may contain substances which increase the viscosity of the suspension, such as sodium carboxymethyl cellulose, sorbitol, or dextran. Optionally, the suspension may also contain suitable stabilizers or agents which increase the solubility of the compounds to allow for the preparation of highly concentrated solutions.

[0328] Pharmaceutical compositions may also be formulated as a depot preparation. Such long acting formulations may be administered by implantation (for example subcutaneously or intramuscularly) or by intramuscular injection. Thus, for example, the compounds may be formulated with suitable polymeric or hydrophobic materials (for example, as an emulsion in an acceptable oil) or ion exchange resins, or as sparingly soluble derivatives, for example, as a sparingly soluble salt.

[0329] For buccal or sublingual administration, the compositions may take the form of tablets, lozenges, pastilles, or gels formulated in conventional manner. Such compositions may comprise the active ingredient in a flavored basis such as sucrose and acacia or tragacanth.

[0330] Pharmaceutical compositions may also be formulated in rectal compositions such as suppositories or retention enemas, e.g., containing conventional suppository bases such as cocoa butter, polyethylene glycol, or other glycerides.

[0331] Pharmaceutical compositions may be administered topically, that is by non-sy...

Claims

1. A compound of Formula (I'), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, pyrazolyl, furanyl, thienyl, pyrrolyl, imidazolyl, triazolyl, tetrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, or thiadiazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, or triazinyl; X1, X5, X6, and X7 are each independently CR7 or N; wherein at least one of X1, X5, X6, and X7 are CR7; R1 is selected from H, halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), - S(=O)2N(R17)2, -OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)(C1-C4alkyl), -NR17C(=O)O(C1-C4alkyl), -OC(=O)N(R17)2, - NR1SC(=O)N(R17)2, -SH, -S(C1-C4alkyl), -S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4heteroalkyl, C3-C6cycloalkyl, and monocyclic C2-C5heterocycloalkyl; X2 is CR2 or N; R2 is H, halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), -S(=O)2N(R17)2, - OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)(C1-C4alkyl), -NR17C(=O)O(C1-C4alkyl), -OC(=O)N(R17)2, -NR 17C(=O)N(R17)2, -SH, -S(C1-C4alkyl), -S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4heteroalkyl, C3-C6cycloalkyl, or monocyclic C2-C5heterocycloalkyl; or R1 and R2 are taken together with the intervening atoms to form a fused 5- or 6-membered ring with 0-3 N atoms and 0-2 O or S atoms in the ring, wherein the fused 5- or 6-membered ring is optionally substituted with halogen or C1-C4alkyl; X3 is CR3 or N; R3 is H, halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), -OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)(C1-C4alkyl), C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, or C1-C4heteroalkyl; each X4 is independently CH, CF, or N; R4 is H, F, or -CH3; R5 is H, F, or -CH3; or R4 and R5 are taken together to form a bridge that is -CH2- or -CH2CH2-; each R6 is independently H, F, -OH, or -CH3; L is absent, -Y2-L1-, -L1-Y2-, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y2 is absent, -O-, -S-, -S(=O)-, -S(=O)2-, -S(=O)2NR17-, -CH2-, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR17-, -NR17C(=O)-, - OC(=O)NR17-, -NR17C(=O)O-, -NR17C(=O)NR17-, -NR17S(=O)2-, or -NR17-; L1 is absent or C1-C4alkylene; each R7 is independently selected from H, halogen, -CN, -OH, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C3-C6cycloalkyl, and C1-C4heteroalkyl; R8 is C4-C8alkyl or C4-C8haloalkyl; R9 is H, F, or -CH3; R10 is -OC(=O)N(R12)(R13), -N(R16)C(=O)R14, or -N(R16)C(=O)OR15; R11 is H, F, or -CH3; R12 is -C1-C6alkyl-OR17 or monocyclic C2-C5heterocycloalkyl optionally substituted with one or two oxo groups; R13 is H or C1-C4alkyl; or R12 and R13 are taken together to form a 4-, 5-, or 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C1-C4alkyl)2, C1-C6alkyl, C1-C6alkoxy, -S(C1-C4alkyl), - S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), -C1-C4alkyl-S(=O)2(C1-C4alkyl), -C1-C6alkyl-OR17, and -O-C1-C6alkyl-OR17; R14 is C1-C6alkyl, C3-C6cycloalkyl, or -C1-C6alkyl-OR17; R15 is C1-C6alkyl, -C1-C6alkyl-OR17, C3-C6cycloalkyl, or C2-C6heterocycloalkyl; R16 is H or C1-C6alkyl; each R17 is independently H or C1-C6alkyl; each R18 is independently halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), - S(C1-C4alkyl), -S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), -S(=O)2N(R17)2, - C(=O)(C1-C4alkyl), -OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), - NR17C(=O)(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)O(C1-C4alkyl), - OC(=O)N(R17)2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4heteroalkyl, C3-C6cycloalkyl, monocyclic C2-C6heterocycloalkyl, phenyl, or monocyclic heteroaryl; m is 0, 1, or 2; and n is 0, 1, or 2.

2. The compound of claim 1, or a pharmaceutically acceptable salt or solvate thereof, wherein the compound has the structure of Formula (Ia'), or a pharmaceutically acceptable salt or solvate thereof:

3. The compound of claim 1 or 2, or a pharmaceutically acceptable salt or solvate thereof, wherein X1 is N, and X5, X6, and X7 are CH.

4. The compound of claim 1 or 2, or a pharmaceutically acceptable salt or solvate thereof, wherein X1 and X6 are N, and X5 and X7 are CH.

5. The compound of claim 1 or 2, or a pharmaceutically acceptable salt or solvate thereof, wherein X1 and X7 are N, and X5 and X6 are CH.

6. The compound of claim 1 or 2, or a pharmaceutically acceptable salt or solvate thereof, wherein X1, X5, X6, and X7 are CH.

7. A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, pyrazolyl, furanyl, thienyl, pyrrolyl, imidazolyl, triazolyl, tetrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, or thiadiazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, or triazinyl; X1 is C(H), C(F), or N; R1 is selected from H, halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), - S(=O)2N(R17)2, -OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)(C1-C4alkyl), -NR17C(=O)O(C1-C4alkyl), -OC(=O)N(R17)2, - NR15C(=O)N(R17)2, -SH, -S(C1-C4alkyl), -S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4heteroalkyl, and monocyclic C2-C5heterocycloalkyl; X2 is CR2 or N; R2 is H, halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), -S(=O)2N(R17)2, - OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)(C1-C4alkyl), -NR17C(=O)O(C1-C4alkyl), -OC(=O)N(R17)2, -NR 17C(=O)N(R17)2, -SH, -S(C1-C4alkyl), -S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4heteroalkyl, or monocyclic C2-C5heterocycloalkyl; or R1 and R2 are taken together with the intervening atoms to form a fused 5- or 6-membered ring with 0-3 N atoms and 0-2 O or S atoms in the ring, wherein the fused 5- or 6-membered ring is optionally substituted with halogen or C1-C4alkyl; X3 is CR3 or N; R3 is H, halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), -OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)(C1-C4alkyl), C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, or C1-C4heteroalkyl; each X4 is independently CH or N; R4 is H, F, or -CH3; R5 is H, F, or -CH3; or R4 and R5 are taken together to form a bridge that is -CH2- or -CH2CH2-; each R6 is independently H, F, -OH, or -CH3; L is absent, -Y2-L1-, -L1-Y2-, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y2 is absent, -O-, -S-, -S(=O)-, -S(=O)2-, -S(=O)2NR17-, -CH2-, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR17-, -NR17C(=O)-, - OC(=O)NR17-, -NR17C(=O)O-, -NR17C(=O)NR17-, -NR17S(=O)2-, or -NR17-; L1 is absent or C1-C4alkylene; each R7 is independently selected from H, halogen, -CN, -OH, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, and C1-C4heteroalkyl; R8 is C4-C8alkyl or C4-C8haloalkyl; R9 is H, F, or -CH3; R10 is -OC(=O)N(R12)(R13), -N(R16)C(=O)R14, or -N(R16)C(=O)OR15; R11 is H, F, or -CH3; R12 is -C1-C6alkyl-OR17 or monocyclic C2-C5heterocycloalkyl optionally substituted with one or two oxo groups; R13 is H or C1-C4alkyl; or R12 and R13 are taken together to form a 4-, 5-, or 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C1-C4alkyl)2, C1-C6alkyl, C1-C6alkoxy, -S(C1-C4alkyl), - S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), -C1-C4alkyl-S(=O)2(C1-C4alkyl), -C1-C6alkyl-OR17, and -O-C1-C6alkyl-OR17; R14 is C1-C6alkyl or -C1-C6alkyl-OR 17; R15 is C1-C6alkyl, -C1-C6alkyl-OR17, or C2-C6heterocycloalkyl; R16 is H or C1-C6alkyl; each R17 is independently H or C1-C6alkyl; each R18 is independently halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), - S(C1-C4alkyl), -S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), -S(=O)2N(R17)2, - C(=O)(C1-C4alkyl), -OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), - NR17C(=O)(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)O(C1-C4alkyl), - OC(=O)N(R17)2, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4heteroalkyl, C3-C6cycloalkyl, monocyclic C2-C6heterocycloalkyl, phenyl, or monocyclic heteroaryl; m is 0, 1, or 2; and n is 0, 1, or 2.

8. The compound of claim 7, or a pharmaceutically acceptable salt or solvate thereof, wherein the compound has the structure of Formula (Ia), or a pharmaceutically acceptable salt or solvate thereof:

9. The compound of any one of claims 1-8, or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is a 5-membered heteroaryl that is oxazolyl, thiazolyl, imidazolyl, or pyrazolyl; or ring A is a 6-membered heteroaryl that is pyridinyl or pyrimidinyl.

10. The compound of any one of claims 1-9, or a pharmaceutically acceptable salt or solvate thereof, wherein n is 0.

11. The compound of claim 10, or a pharmaceutically acceptable salt or solvate thereof, wherein 12. The compound of any one of claims 1-11, or a pharmaceutically acceptable salt or solvate thereof, wherein R10 is -OC(=O)N(R12)(R13).

13. The compound of any one of claims 1-12, or a pharmaceutically acceptable salt or solvate thereof, wherein R12 is -C1-C6alkyl-OR17.

14. The compound of any one of claims 1-13, or a pharmaceutically acceptable salt or solvate thereof, wherein R12 is -CH2CH2OH, -CH2CH2CH2OH, or - CH2CH2C(CH3)2OH.

15. The compound of any one of claims 1-14, or a pharmaceutically acceptable salt or solvate thereof, wherein R13 is H.

16. The compound of any one of claims 1-12, or a pharmaceutically acceptable salt or solvate thereof, wherein R12 and R13 are taken together to form a 4-, 5-, or 6-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C1-C4alkyl)2, C1-C6alkyl, C1-C6alkoxy, -S(=O)2(C1-C4alkyl), -C1-C4alkyl-S(=O)2(C1-C4alkyl), -C1-C6alkyl-OR17, and -O-C1-C6alkyl-OR17.

17. A compound of Formula (II), or a pharmaceutically acceptable salt or solvate thereof: wherein: ring A is X1 is CH or N; R1 is H, halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), -S(=O)2N(R17)2, - OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)(C1-C4alkyl), -NR17C(=O)O(C1-C4alkyl), -OC(=O)N(R17)2, -NR15C(=O)N(R17)2, -SH, -S(C1-C4alkyl), -S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4heteroalkyl, or monocyclic C2-C5heterocycloalkyl; X2 is CR2 or N; R2 is H, halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), -S(=O)2N(R17)2, - OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)(C1-C4alkyl), -NR17C(=O)O(C1-C4alkyl), -OC(=O)N(R17)2, -NR 17C(=O)N(R17)2, -SH, -S(C1-C4alkyl), -S(=O)(C1-C4alkyl), -S(=O)2(C1-C4alkyl), C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, C1-C4heteroalkyl, or monocyclic C2-C5heterocycloalkyl; or R1 and R2 are taken together with the intervening atoms to form a fused 5- or 6-membered ring with 0-3 N atoms and 0-2 O or S atoms in the ring, wherein the fused 5- or 6-membered ring is optionally substituted with halogen or C1-C4alkyl; X3 is CR3 or N; R3 is H, halogen, -CN, -OH, -N(R17)2, -NR17S(=O)2(C1-C4alkyl), -OC(=O)(C1-C4alkyl), -CO2H, -CO2(C1-C4alkyl), -C(=O)N(R17)2, -NR17C(=O)(C1-C4alkyl), C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, or C1-C4heteroalkyl; each X4 is independently CH or N; R4 is H, F, or -CH3; R5 is H, F, or -CH3; or R4 and R5 are taken together to form a bridge that is -CH2- or -CH2CH2-; each R6 is independently H, F, -OH, or -CH3; R7 is H, halogen, -CN, -OH, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C1-C4fluoroalkyl, C1-C4fluoroalkoxy, or C1-C4heteroalkyl; L is absent, -Y2-L1-, -L1-Y2-, cyclopropylene, cyclobutylene, or bicyclo[1.1.1]pentylene; Y2 is absent, -O-, -S-, -S(=O)-, -S(=O)2-, -S(=O)2NR17-, -CH2-, -CH=CH-, -C≡C-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR17-, -NR17C(=O)-, - OC(=O)NR17-, -NR17C(=O)O-, -NR17C(=O)NR17-, -NR17S(=O)2-, or -NR17-; L1 is absent or C1-C4alkylene; R8 is C4-C8alkyl; R9 is H, F, or -CH3; R10 is -OC(=O)N(R12)(R13), -N(R16)C(=O)R14, or -N(R16)C(=O)OR15; R11 is H, F, or -CH3; R12 and R13 are taken together to form a 4-, 5-, or 6- membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1, 2, or 3 groups selected from -OH, -N(C1-C4alkyl)2, C1-C6alkyl, and C1-C6alkoxy; R14 is C1-C6alkyl or -C1-C6alkyl-OR 17; R15 is C1-C6alkyl, -C1-C6alkyl-OR17, or C2-C6heterocycloalkyl; R16 is H or C1-C6alkyl; each R17 is independently H or C1-C6alkyl; and m is 0, 1, or 2.

18. The compound of claim 17, or a pharmaceutically acceptable salt or solvate thereof, wherein the compound has the structure of Formula (IIa), or a pharmaceutically acceptable salt or solvate thereof:

19. The compound of any one of claims 1-18, or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is 20. The compound of any one of claims 1-18, or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is 21. The compound of any one of claims 1-18, or a pharmaceutically acceptable salt or solvate thereof, wherein ring A is 22. The compound of any one of claims 1-21, or a pharmaceutically acceptable salt or solvate thereof, wherein R8 is -C(CH3)3.

23. The compound of any one of claims 7-22, or a pharmaceutically acceptable salt or solvate thereof, wherein X1 is N.

24. The compound of any one of claims 7-22, or a pharmaceutically acceptable salt or solvate thereof, wherein X1 is CH.

25. The compound of any one of claims 1-24, or a pharmaceutically acceptable salt or solvate thereof, wherein R4 is H and R5 is H.

26. The compound of any one of claims 1-24, or a pharmaceutically acceptable salt or solvate thereof, wherein R4 and R5 are taken together to form a bridge that is -CH2- or -CH2CH2-.

27. The compound of any one of claims 1-24, or a pharmaceutically acceptable salt or solvate thereof, wherein R4 and R5 are taken together to form a bridge that is - CH2CH2-.

28. The compound of any one of claims 17-27, or a pharmaceutically acceptable salt or solvate thereof, wherein R10 is -OC(=O)N(R12)(R13).

29. The compound of claim 16 or claim 28, or a pharmaceutically acceptable salt or solvate thereof, wherein R12 and R13 are taken together to form a 4-membered or 5-membered heterocycloalkyl ring optionally containing an additional heteroatom selected from O, S, and N and optionally substituted with 1 or 2 groups selected from -OH, -N(C1-C4alkyl)2, C1-C6alkyl, and C1-C6alkoxy.

30. The compound of claim 29, or a pharmaceutically acceptable salt or solvate thereof, wherein R10 is 31. The compound of claim 29, or a pharmaceutically acceptable salt or solvate thereof, wherein R10 is 32. The compound of any one of claims 1-11 and 17-27, or a pharmaceutically acceptable salt or solvate thereof, wherein R10 is -N(R16)C(=O)R14.

33. The compound of claim 32, or a pharmaceutically acceptable salt or solvate thereof, wherein R14 is C1-C6alkyl.

34. The compound of claim 32, or a pharmaceutically acceptable salt or solvate thereof, wherein R14 is -C1-C6alkyl-OR17.

35. The compound of any one of claims 1-11 and 17-27, or a pharmaceutically acceptable salt or solvate thereof, wherein R10 is -N(R16)C(=O)OR15.

36. The compound of claim 35, or a pharmaceutically acceptable salt or solvate thereof, wherein R15 is C1-C6alkyl.

37. The compound of claim 35, or a pharmaceutically acceptable salt or solvate thereof, wherein R15 is -C1-C6alkyl-OR17.

38. The compound of claim 35, or a pharmaceutically acceptable salt or solvate thereof, wherein R15 is C2-C6heterocycloalkyl.

39. The compound of any one of claims 1-38, or a pharmaceutically acceptable salt or solvate thereof, wherein R16 is H.

40. The compound of any one of claims 1-39, or a pharmaceutically acceptable salt or solvate thereof, wherein one X4 is CH and one X4 is N.

41. The compound of any one of claims 1-39, or a pharmaceutically acceptable salt or solvate thereof, wherein each X4 is CH.

42. The compound of any one of claims 1-41, or a pharmaceutically acceptable salt or solvate thereof, wherein X3 is CH.

43. The compound of any one of claims 1-42, or a pharmaceutically acceptable salt or solvate thereof, wherein X2 is CR2.

44. The compound of any one of claims 1-43, or a pharmaceutically acceptable salt or solvate thereof, wherein R2 is halogen, -CN, or C1-C4alkyl.

45. The compound of any one of claims 1-44, or a pharmaceutically acceptable salt or solvate thereof, wherein R2 is C1-C4alkyl.

46. The compound of any one of claims 1-45, or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is C1-C4alkyl or C1-C4alkoxy.

47. The compound of any one of claims 1-46, or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is C1-C4alkoxy.

48. The compound of any one of claims 1-47, or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is -OCH3.

49. The compound of any one of claims 1-48, or a pharmaceutically acceptable salt or solvate thereof, wherein L is absent.

50. The compound of any one of claims 1-49, or a pharmaceutically acceptable salt or solvate thereof, wherein m is 0.

51. The compound of any one of claims 1-50, or a pharmaceutically acceptable salt or solvate thereof, wherein R9 is H.

52. The compound of any one of claims 1-51, or a pharmaceutically acceptable salt or solvate thereof, wherein R11 is H.

53. The compound of any one of claims 1-52, or a pharmaceutically acceptable salt or solvate thereof, wherein each R7 is H.

54. A compound selected from: or a pharmaceutically acceptable salt or solvate thereof.

55. A compound selected from: or a pharmaceutically acceptable salt or solvate thereof.

56. A compound selected from: or a pharmaceutically acceptable salt or solvate thereof.

57. A pharmaceutical composition comprising a compound of any one of claims 1-56, or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable excipient.

58. The pharmaceutical composition of claim 57, wherein the pharmaceutical composition is formulated for administration to a mammal by intravenous administration, subcutaneous administration, oral administration, inhalation, nasal administration, dermal administration, or ophthalmic administration.

59. The pharmaceutical composition of claim 57, wherein the pharmaceutical composition is in the form of a tablet, a pill, a capsule, a liquid, a suspension, a gel, a dispersion, a solution, an emulsion, an ointment, or a lotion.

60. A method of treating or preventing a liver disease or condition in a mammal, comprising administering to the mammal a compound of any one of claims 1-56, or a pharmaceutically acceptable salt or solvate thereof.

61. The method of claim 60, wherein the liver disease or condition is an alcoholic or non-alcoholic liver disease or condition.

62. The method of claim 60, wherein the liver disease or condition is primary biliary cirrhosis, primary sclerosing cholangitis, cholestasis, nonalcoholic steatohepatitis (NASH), or nonalcoholic fatty liver disease (NAFLD).

63. The method of claim 61, wherein the alcoholic liver disease or condition is fatty liver (steatosis), cirrhosis, or alcoholic hepatitis.

64. The method of claim 61, wherein the non-alcoholic liver disease or condition is nonalcoholic steatohepatitis (NASH), or nonalcoholic fatty liver disease (NAFLD).

65. The method of claim 61, wherein the non-alcoholic liver disease or condition is nonalcoholic steatohepatitis (NASH).

66. The method of claim 61, wherein the non-alcoholic liver disease or condition is nonalcoholic steatohepatitis (NASH) and is accompanied by liver fibrosis.

67. The method of claim 61, wherein the non-alcoholic liver disease or condition is nonalcoholic steatohepatitis (NASH) without liver fibrosis.

68. The method of claim 61, wherein the non-alcoholic liver disease or condition is intrahepatic cholestasis or extrahepatic cholestasis.

69. A method of treating or preventing a liver fibrosis in a mammal, comprising administering to the mammal a compound of any one of claims 1-56, or a pharmaceutically acceptable salt or solvate thereof.

70. The method of claim 69, wherein the mammal is diagnosed with hepatitis C virus (HCV), nonalcoholic steatohepatitis (NASH), primary sclerosing cholangitis (PSC), cirrhosis, Wilson's disease, hepatitis B virus (HBV), HIV associated steatohepatitis and cirrhosis, chronic viral hepatitis, non-alcoholic fatty liver disease (NAFLD), alcoholic steatohepatitis (ASH), primary biliary cirrhosis (PBC), or biliary cirrhosis.

71. The method of claim 69, wherein the mammal is diagnosed with nonalcoholic steatohepatitis (NASH).

72. A method of treating or preventing a liver inflammation in a mammal, comprising administering to the mammal a compound of any one of claims 1-56, or a pharmaceutically acceptable salt or solvate thereof.

73. The method of claim 72, wherein the mammal is diagnosed with hepatitis C virus (HCV), nonalcoholic steatohepatitis (NASH), primary sclerosing cholangitis (PSC), cirrhosis, Wilson's disease, hepatitis B virus (HBV), HIV associated steatohepatitis and cirrhosis, chronic viral hepatitis, non-alcoholic fatty liver disease (NAFLD), alcoholic steatohepatitis (ASH), primary biliary cirrhosis (PBC), or biliary cirrhosis.

74. The method of claim 72, wherein the mammal is diagnosed with nonalcoholic steatohepatitis (NASH).

75. The method of claim 72, wherein the liver inflammation is associated with inflammation in the gastrointestinal tract.

76. The method of claim 72, wherein the mammal is diagnosed with inflammatory bowel disease.

77. A method of treating or preventing a gastrointestinal disease or condition in a mammal, comprising administering to the mammal a compound of any one of claims 1-56, or a pharmaceutically acceptable salt or solvate thereof.

78. The method of claim 77, wherein the gastrointestinal disease or condition is necrotizing enterocolitis, gastritis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, irritable bowel syndrome, gastroenteritis, radiation induced enteritis, pseudomembranous colitis, chemotherapy induced enteritis, gastro-esophageal reflux disease (GERD), peptic ulcer, non-ulcer dyspepsia (NUD), celiac disease, intestinal celiac disease, post-surgical inflammation, gastric carcinogenesis, graft versus host disease, or any combination thereof.

79. The method of claim 77, wherein the gastrointestinal disease or condition is irritable bowel syndrome with diarrhea (IBS-D), irritable bowel syndrome with constipation (IBS-C), mixed IBS (IBS-M), unsubtyped IBS (IBS-D), or bile acid diarrhea (BAD).

80. A method of treating or preventing a disease or condition in a mammal that would benefit from treatment with an FXR agonist, comprising administering to the mammal a compound of any one of claims 1-56, or a pharmaceutically acceptable salt or solvate thereof.

81. The method of any one of claims 60-80, further comprising administering at least one additional therapeutic agent in addition to the compound of any one of claims 1-56, or a pharmaceutically acceptable salt or solvate thereof.

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