Microbial consortia

Abstract

The present disclosure provides microbial consortia, and methods of making and using the same, comprising a complete microbiome replacement capable of stable engraftment in the gastrointestinal tract for the treatment of IBD, ulcerative colitis, and Crohn's disease.

Description

MICROBIAL CONSORTIACROSS-REFERENCE TO RELATED APPLICATIONSThe instant application claims priority to U.S. Provisional Patent Application No. 63 / 451,442, filed March 10, 2023, and to U.S. Provisional Patent Application No. 63 / 469,080, filed May 26, 2023, the content of each of which is incorporated in its entirety, and to each of which priority is claimed.SEQUENCE LISTINGThe instant application contains a Sequence Listing which has been submitted electronically in XML format and is hereby incorporated by reference in its entirety. Said XML copy, created on March 7, 2024, is named 0915920112. xml, and is 393,216 bytes in size.FIELD OF THE INVENTIONThe present disclosure relates to microbial consortia for the treatment of dysbiosis of the gut and / or irritable bowel disease.BACKGROUNDThe gastrointestinal tract comprises various biological niches along its longitudinal length having different physical, chemical, and nutrient compositions. As a consequence of these diverse conditions, specific microbial communities are established within a particular biological niche. The microbial species comprising a specific microbial community are highly responsive to their local environment and produce an array of bioactive molecules that facilitate host engraftment, inter-microbial communication, nutrient metabolism, and inclusion or exclusion of competing microbial species. Adding further complexity, there is substantial diversity of microbial species and strains in the human gastrointestinal tract between individuals, which is attributed to a number of factors including genetics, diet, antibiotic and antifungal use, surgical intervention (e.g., gastric by-pass / bowel resection), presence of inflammatory bowel disease and / or irritable bowel syndrome, and other environmental influences. However, despite this interindividual diversity, the functional attributes of the varying human gut microbiota are relatively consistent among healthy adults and comprise core metabolic pathways involved in carbohydrate metabolism, amino acid metabolism, fermentation, and oxidative phosphorylation.Modulation of microbial species in the gastrointestinal tract through the use of antibiotics, antifungals, and more recently, fecal microbial transplantation (“FMT”), have been approaches clinically investigated for the treatment and / or prevention of certain diseases and disorders. For example, Dodd et al. (Nature, 2007, 551 : 648-652) have proposed FMT as a therapeutic tomodulate the levels of aromatic amino acid metabolites in the serum of gnotobiotic mice, which affect intestinal permeability and systemic immunity.As a modality for treating various diseases and / or conditions, there is a need for microbial compositions comprising a plurality of microbial species having improved therapeutic efficacy and an ability to efficiently engraft in a host, grow, and metabolize pathogenic substrates to non- pathogenic metabolic products within the various biological niches of the gastrointestinal tract and within the diverse gastrointestinal environments of different individuals. Furthermore, there is an unmet need for a treatment of diseases using a complex microbial community that can engraft and function symbiotically in the human gastrointestinal tract to degradation of a disease- associated metabolic substrate.SUMMARY OF THE INVENTIONThe present disclosure provides methods for preventing, decreasing, and / or treating dysbiosis in a subject. In certain embodiments, the methods comprise administering an effective amount of a microbial consortium or a pharmaceutical composition thereof comprising a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum,Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum,Lactobacillus rogosae, Bacteroides faecis, Bacteroides fmegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcus intestim, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium halhi, Anaerofustis stercorihominis, Eubacterium ventriosum, Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; or b) FBI00001, FB 100002, FB 100010, FBI00013, FBI00029, FBI00032, FBI00033, FBI00034, FBI00043, FBI00044, FBI00048, FB 100050, FBI00051, FBI00057, FBI00059, FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102, FBI00109, FBI00117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162, FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FBI00206, FBI00211, FBI00220, FBI00221, FBI00236, FBI00245, FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises: a) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutterella wadsworthensis, Sutterella massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatiformans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; b) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiellatayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and / or c) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises:a) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FBI00038,FB 100040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081,FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140,FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224,FBI00226, FBI00229, FBI00233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; b) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126,FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and / or c) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a second strain of Oxalobacter formigenes or FBI00133. In certain embodiments, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a third strain of Oxalobacter formigenes or FB 100289.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises: a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides finegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcusintestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum, Blautia hydrogenotrophica, and Lachnospiraceae sp FBI00290, or a functional equivalent thereof, b) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutterella wadsworthensis, Sutterella massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatiformans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; c) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiellatayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and d) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises: a) FBI00001, FBI00002, FBI00010, FBI00013, FBI00029, FBI00032, FBI00033, FBI00034, FBI00043, FBI00044, FBI00048, FBI00050, FBI00051, FBI00057, FBI00059, FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FBI00117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FBI00206, FBI002U, FBI00220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof; b) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FBI00038, FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081,FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140,FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224,FBI00226, FBI00229, FBI00233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; c) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126, FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and d) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, a second strain of Oxalobacter formigenes or FBI00133, and a third strain of Oxalobacter formigenes or FBI00289. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, a second strain of Oxalobacter formigenes or FBI00133, and a third strain of Oxalobacter formigenes or FBI00289. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof is FB-001 or a functional equivalent thereof. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof is FB-003 or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof increases the microbial diversity of the gastrointestinal tract. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof increases short chain fatty acids (SCFAs). In certain embodiments, the microbial consortium or a pharmaceutical composition thereof increases secondary bile acids. In certain embodiments, the microbial consortium or apharmaceutical composition thereof decreases bacterial pathogens in the gastrointestinal tract of the subject.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 * 109and about 5 x 1012viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 109and about 5 x 1O10viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x io10and about 5 x io11viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 1011and about 5 x 1012viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises up to about 1011viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises up to about 1012viable cells.In certain embodiments, the methods comprise administering a loading dose and one or more maintenance doses. In certain embodiments, the loading dose is administered for 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, or 10 days. In certain embodiments, the loading dose is administered for 2-3 days, 3-5 days, 4-6 days, or 5-7 days. In certain embodiments, the one or more maintenance doses are administered for at least 21 days following the last loading dose.In certain embodiments, the methods further comprise administering an antibacterial agent, an antiviral agent, an antifungal agent, anti-inflammatory agent, an immunosuppressive agent, and / or a prebiotic. In certain embodiments, the antibacterial agent is selected from the group consisting of ciprofloxacin, levaquin, floxin, tequin, avelox, norflox, cephalexin, cefuroxime, cefadroxil, cefazolin, cephalothin, cefaclor, cefamandole, cefoxitin, cefprozil, ceftobiprole, amoxicillin, ampicillin, penicillin V, dicloxacillin, carbenicillin, vancomycin, and methicillin, tetracycline, minocycline, oxytetracycline, doxycycline, ertapenem, doripenem, imipenem / cilastatin, and meropenem. In certain embodiments, the antiviral agent is selected from the group consisting of abacavir, acyclovir, adefovir, amprenavir, atazanavir, cidofovir, darunavir, delavirdine, didanosine, docosanol, efavirenz, elvitegravir, emtricitabine, enfuviltide, etravirine, famciclovir, foscamet, fomivirsen, ganciclovir, indinavir, idoxuridine, lamivudine, lopinavir maraviroc, mk-2048, nelfinavir, nevirapine, nirmatrelvir, penciclovir, raltegravir, rilpivirine, ritonavir, saquinavir, stavudine, tenofovir trifluridine, valaciclovir, valganciclovir, vidarabine, ibacitabine, amantadine, oseltamivir, rimantidine, tipranavir, zalcitabine, zanamivir, and zidovudine. In certain embodiments, the antifungal agent is selected from the group consisting of miconazole, ketoconazole, clotrimazole, econazole, omoconazole, bifonazole, butoconazole, fenticonazole, isoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, fluconazole,itraconazole, isavuconazole, ravuconazole, posaconazole, voriconazok, terconazole, albaconazole, abafungin, terbinafine, naftifine, butenafine, anidulafungin, caspofungin, micafungin, polygodial, benzoic acid, ciclopirox, tolnaftate, undecylenic acid, flucytosine or 5- fluorocytosine, griseofulvin, and haloprogin. In certain embodiments, the anti-inflammatory and / or immunosuppressive agent is selected from the group consisting of cyclophosphamide, mycophenolate mofetil, corticosteroids, mesalazine, mesalamine, sulfasalazine, sulfasalazine derivatives, cyclosporin A, mercaptopurine, azathiopurine, prednisone, methotrexate, antihistamines, glucocorticoids, epinephrine, theophylline, cromolyn sodium, anti-leukotrienes, anticholinergics, monoclonal anti-IgE, immunomodulatory peptides, immunomodulatory small molecules, immunomodulatory cytokines, immunomodulatory antibodies, and vaccines. In certain embodiments, the prebiotic is selected from the group consisting of amino acids, biotin, fructooligosaccharides, galactooligosaccharides, inulin, lactulose, mannan oligosaccharides, oligofructose-enriched inulin, oligofructose, oligodextrose, tagatose, transgalactooligosaccharide, and xylooligosaccharides.In certain embodiments, the microbial consortium or pharmaceutical composition thereof is present in a food product.The present disclosure also provides methods for restoring microbiome and / or recovering a healthy microbiome in a subject. In certain embodiments, the methods comprise administering an effective amount of a microbial consortium or a pharmaceutical composition thereof comprising: a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides fmegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum, Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; orb) FBI00001, FB 100002, FB 100010, FBI00013, FBI00029, FBI00032, FBI00033,FBI00034, FBI00043, FBI00044, FBI00048, FB 100050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FB IOO117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FB 100206, FBI00211, FB 100220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises: a) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutterella wadsworthensis, Sutterella massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatiformans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; b) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiellatayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and / or c) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroidescoprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereofIn certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises: a) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FBI00038, FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081, FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140, FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224, FBI00226, FBI00229, FB 100233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; b) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126,FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and / or c) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereofIn certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a second strain of Oxalobacter formigenes or FBI00133. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a third strain of Oxalobacter formigenes or FB 100289.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises: a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum,Lactobacillus rogosae, Bacteroides faecis, Bacteroides fmegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum, Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; b) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutterella wadsworthensis, Sutterella massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatiformans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; c) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiella tayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and d) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises: a) FBI00001, FB 100002, FBI00010, FBI00013, FB 100029, FBI00032, FBI00033,FBI00034, FBI00043, FBI00044, FBI00048, FB 100050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FB 100117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FB 100206, FBI00211, FB 100220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof; b) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FB 100038, FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081, FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140, FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224, FBI00226, FBI00229, FB 100233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; c) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126, FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and d) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereofIn certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, a second strain of Oxalobacter formigenes or FBI00133, and a third strain of Oxalobacter formigenes or FBI00289. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, a second strain of Oxalobacter formigenes or FBI00I33, and a third strain of Oxalobacter formigenes or FBI00289. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof is FB-001 or a functional equivalent thereof. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof is FB-003 or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof increases the microbial diversity of the gastrointestinal tract. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof increases short chain fatty acids (SCFAs). In certain embodiments, the microbial consortium or a pharmaceutical composition thereof increases secondary bile acids. In certain embodiments, wherein the microbial consortium or a pharmaceutical composition thereof decreases bacterial pathogens in the gastrointestinal tract of the subject.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 109and about 5 x 1012viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 109and about 5 x 1O10viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 1O10and about 5 x 1011viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x io11and about 5 x io12viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises up to about 1011viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises up to about 1012viable cells. In certain embodiments, the method comprises administering a loading dose and one or more maintenance doses. In certain embodiments, the loading dose is administered for 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, or 10 days. In certain embodiments, the loading dose is administered for 2-3 days, 3-5 days, 4-6 days, or 5-7 days. In certain embodiments, the one or more maintenance doses are administered for at least 21 days following the last loading dose.In certain embodiments, the methods further comprise administering an antibacterial agent, an antiviral agent, an antifungal agent, anti-inflammatory agent, an immunosuppressive agent, and / or a prebiotic. In certain embodiments, the antibacterial agent is selected from the group consisting of ciprofloxacin, levaquin, floxin, tequin, avelox, norflox, cephalexin, cefuroxime, cefadroxil, cefazolin, cephalothin, cefaclor, cefamandole, cefoxitin, cefprozil, ceftobiprole, amoxicillin, ampicillin, penicillin V, dicloxacillin, carbenicillin, vancomycin, and methicillin, tetracycline, minocycline, oxytetracycline, doxycycline, ertapenem, doripenem, imipenem / cilastatin, and meropenem. In certain embodiments, the antiviral agent is selected from the group consisting of abacavir, acyclovir, adefovir, amprenavir, atazanavir, cidofovir, darunavir, delavirdine, didanosine, docosanol, efavirenz, elvitegravir, emtricitabine, enfuviltide, etravirine, famciclovir, foscamet, fomivirsen, ganciclovir, indinavir, idoxuridine, lamivudine, lopinavir maraviroc, mk-2048, nelfinavir, nevirapine, nirmatrelvir, penciclovir, raltegravir, rilpivirine, ritonavir, saquinavir, stavudine, tenofovir trifluridine, valaciclovir, valganciclovir, vidarabine,ibacitabine, amantadine, oseltamivir, rimantidine, tipranavir, zalcitabine, zanamivir, and zidovudine. In certain embodiments, the antifungal agent is selected from the group consisting of miconazole, ketoconazole, clotrimazole, econazole, omoconazole, bifonazole, butoconazole, fenticonazole, isoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, fluconazole, itraconazole, isavuconazole, ravuconazole, posaconazole, voriconazok, terconazole, albaconazole, abafungin, terbinafme, naftifme, butenafme, anidulafungin, caspofungin, micafungin, polygodial, benzoic acid, ciclopirox, tolnaftate, undecylenic acid, flucytosine or 5- fluorocytosine, griseofulvin, and haloprogin. In certain embodiments, the anti-inflammatory and / or immunosuppressive agent is selected from the group consisting of cyclophosphamide, mycophenolate mofetil, corticosteroids, mesalazine, mesalamine, sulfasalazine, sulfasalazine derivatives, cyclosporin A, mercaptopurine, azathiopurine, prednisone, methotrexate, antihistamines, glucocorticoids, epinephrine, theophylline, cromolyn sodium, anti-leukotrienes, anticholinergics, monoclonal anti-IgE, immunomodulatory peptides, immunomodulatory small molecules, immunomodulatory cytokines, immunomodulatory antibodies, and vaccines. In certain embodiments, the prebiotic is selected from the group consisting of amino acids, biotin, fructooligosaccharides, galactooligosaccharides, inulin, lactulose, mannan oligosaccharides, oligofructose-enriched inulin, oligofructose, oligodextrose, tagatose, transgalactooligosaccharide, and xylooligosaccharides.In certain embodiments, the microbial consortium or pharmaceutical composition thereof is present in a food product.Moreover, the present disclosure provides methods for treating a disease in a subject. In certain embodiments, the methods comprise administering an effective amount of a microbial consortium or a pharmaceutical composition thereof comprising: a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides finegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcusintestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum, Blautia hydrogenotrophica, andLachnospiraceae sp FBI00290, or a functional equivalent thereof, or b) FBI00001, FBI00002, FBI00010, FBI00013, FBI00029, FBI00032, FBI00033, FBI00034, FBI00043, FBI00044, FBI00048, FBI00050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FBI00117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FBI00206, FBI00211, FBI00220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof.In certain embodiments, the disease is irritable bowel syndrome, diarrhea, constipation, celiac disease, and leaky gut syndrome, colitis, ulcerative colitis, or Crohn’s disease.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises: a) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutterella wadsworthensis, Sutterella massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatiformans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; b) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiellatayi, Dorealongicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and / or c) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, andSenegalimassilia anaerobia, or a functional equivalent thereof.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises: a) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FBI00038,FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081,FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140,FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224,FBI00226, FBI00229, FB 100233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; b) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126, FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and / or c) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereofIn certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a second strain of Oxalobacter formigenes or FBI00133.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a third strain of Oxalobacter formigenes or FBI00289.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises: a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroidesnordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides finegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum, Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; b) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutterella wadsworthensis, Sutterella massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatiformans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; c) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiella tayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; andd) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereofIn certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises: a) FBI00001, FBI00002, FBI00010, FBI00013, FBI00029, FBI00032, FBI00033, FBI00034, FBI00043, FBI00044, FBI00048, FBI00050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FBI00117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FBI00206, FBI00211, FBI00220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof; b) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FB 100038,FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081,FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140, FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224, FBI00226, FBI00229, FB 100233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; c) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126, FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and d) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FB 100281, or a functional equivalent thereofIn certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, a second strain of Oxalobacter formigenes or FBI00133, and a third strain of Oxalobacter formigenes or FBI00289. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, a second strain of Oxalobacterformigenes or FBI00133, and a third strain of Oxalobacter formigenes or FB 100289. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof is FB-001 or a functional equivalent thereof In certain embodiments, the microbial consortium or a pharmaceutical composition thereof is FB-003 or a functional equivalent thereof. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof increases the microbial diversity of the gastrointestinal tract. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof increases short chain fatty acids (SCFAs). In certain embodiments, the microbial consortium or a pharmaceutical composition thereof increases secondary bile acids. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof decreases bacterial pathogens in the gastrointestinal tract of the subject.In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 109and about 5 x 1012viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 109and about 5 x 1O10viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 1O10and about 5 x 1011viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x io11and about 5 x io12viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises up to about 1011viable cells. In certain embodiments, the microbial consortium or a pharmaceutical composition thereof comprises up to about 1012viable cells. In certain embodiments, the method comprises administering a loading dose and one or more maintenance doses. In certain embodiments, the loading dose is administered for 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, or 10 days. In certain embodiments, the loading dose is administered for 2-3 days, 3-5 days, 4-6 days, or 5-7 days. In certain embodiments, the one or more maintenance doses are administered for at least 21 days following the last loading dose.In certain embodiments, the methods further comprise administering an antibacterial agent, an antiviral agent, an antifungal agent, anti-inflammatory agent, an immunosuppressive agent, and / or a prebiotic. In certain embodiments, the antibacterial agent is selected from the group consisting of ciprofloxacin, levaquin, floxin, tequin, avelox, norflox, cephalexin, cefuroxime, cefadroxil, cefazolin, cephalothin, cefaclor, cefamandole, cefoxitin, cefprozil, ceftobiprole, amoxicillin, ampicillin, penicillin V, dicloxacillin, carbenicillin, vancomycin, and methicillin, tetracycline, minocycline, oxytetracycline, doxycycline, ertapenem, doripenem, imipenem / cilastatin, and meropenem. In certain embodiments, the antiviral agent is selected from the group consisting of abacavir, acyclovir, adefovir, amprenavir, atazanavir, cidofovir, darunavir, delavirdine, didanosine, docosanol, efavirenz, elvitegravir, emtricitabine, enfuviltide, etravirine,famciclovir, foscamet, fomivirsen, ganciclovir, indinavir, idoxuridine, lamivudine, lopinavir maraviroc, mk-2048, nelfmavir, nevirapine, nirmatrelvir, penciclovir, raltegravir, rilpivirine, ritonavir, saquinavir, stavudine, tenofovir trifluridine, valaciclovir, valganciclovir, vidarabine, ibacitabine, amantadine, oseltamivir, rimantidine, tipranavir, zalcitabine, zanamivir, and zidovudine. In certain embodiments, the antifungal agent is selected from the group consisting of miconazole, ketoconazole, clotrimazole, econazole, omoconazole, bifonazole, butoconazole, fenticonazole, isoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, fluconazole, itraconazole, isavuconazole, ravuconazole, posaconazole, voriconazok, terconazole, albaconazole, abafungin, terbinafme, naftifme, butenafme, anidulafungin, caspofungin, micafungin, polygodial, benzoic acid, ciclopirox, tolnaftate, undecylenic acid, flucytosine or 5- fluorocytosine, griseofulvin, and haloprogin. In certain embodiments, the anti-inflammatory and / or immunosuppressive agent is selected from the group consisting of cyclophosphamide, mycophenolate mofetil, corticosteroids, mesalazine, mesalamine, sulfasalazine, sulfasalazine derivatives, cyclosporin A, mercaptopurine, azathiopurine, prednisone, methotrexate, antihistamines, glucocorticoids, epinephrine, theophylline, cromolyn sodium, anti-leukotrienes, anticholinergics, monoclonal anti-IgE, immunomodulatory peptides, immunomodulatory small molecules, immunomodulatory cytokines, immunomodulatory antibodies, and vaccines. In certain embodiments, the prebiotic is selected from the group consisting of amino acids, biotin, fructooligosaccharides, galactooligosaccharides, inulin, lactulose, mannan oligosaccharides, oligofructose-enriched inulin, oligofructose, oligodextrose, tagatose, transgalactooligosaccharide, and xylooligosaccharides.In certain embodiments, the microbial consortium or pharmaceutical composition thereof is present in a food product. In certain embodiments, the methods discloses herein further comprise diagnosing IBD in the subject before administration of the microbial consortium or pharmaceutical composition thereof.The present disclosure further provides a method for decreasing dysbiosis in a subject, the method comprising administering to a patient a therapeutically effective amount of a pharmaceutical composition comprising a Consortia to decrease dysbiosis of the gastrointestinal tract in the patient. In certain embodiments, decreasing dysbiosis comprises engraftment of microbes of the Consortia, increase in the microbial diversity of the gastrointestinal tract, increase in the short chain fatty acids (SCFAs), increase in secondary bile acids, and / or decrease of bacterial pathogens. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof.In addition, the present disclosure provides a method for restoring the microbiome in a patient, the method comprising administering to the patient a therapeutically effective amount ofa pharmaceutical composition comprising a Consortia. In certain embodiments, the restoring the microbiome comprises engraftment of microbes of the Consortia, increase in the microbial diversity of the gastrointestinal tract, increase in the short chain fatty acids (SCFAs), increase in secondary bile acids, and / or decrease of bacterial pathogens. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof.The present disclosure provides a method for increasing the recovery of a healthy microbiome in a patient after a dysbiosis inducing event, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a Consortia. In certain embodiments, the recovery of a healthy microbiome comprises engraftment of microbes of the Consortia, increase in the microbial diversity of the gastrointestinal tract, increase in the short chain fatty acids (SCFAs), increase in secondary bile acids, and / or decrease of bacterial pathogens. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof. In certain embodiments, the dysbiosis inducing event is treatment with one or more antibiotics, an infectious disease, or an underlying disease. In certain embodiments, the underlying disease is IBD, colitis, ulcerative colitis, or Crohn’s disease.The present disclosure provides a composition for treating or reducing a severity of at least one symptom of a gastrointestinal disease, disorder or condition associated with a dysbiosis in a patient, the composition comprising a Consortia in an amount effective to populate and optionally engraft in a gastrointestinal tract in the patient. In certain embodiments, the gastrointestinal disease is selected from the group consisting of IBD, colitis, ulcerative colitis, and Crohn’s disease. In certain embodiments, the dysbiosis is associated with a decrease in the microbial diversity of the gastrointestinal tract, a decrease in the short chain fatty acids (SCFAs), a decrease in secondary bile acids, and / or an increase of bacterial pathogens. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof.The present disclosure also provides a method of treating or reducing a severity of at least one symptom of a gastrointestinal disease associated with a dysbiosis, the method comprising administering an effective amount of a pharmaceutical composition comprising a Consortia. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof.The present disclosure provides a composition comprising FB-003 or a functional equivalent thereof. The present disclosure provides a method of making FB-003 or a functional equivalent thereof.The present disclosure provides a method of treating IBD, colitis, ulcerative colitis, or Crohn’s disease by administering a Consortia. In certain embodiments, the Consortia is FB-003 or FB-001. The present disclosure provides a method of reducing the symptoms associated with IBD, colitis, ulcerative colitis, or Crohn’s disease by administering a Consortia. In certain embodiments, the Consortia is FB-003 or FB-001. The present disclosure provides any method or composition described herein.BRIEF DESCRIPTION OF THE DRAWINGSFigures 1A and IB. Figure 1A shows an exemplary coculture experiment and Figure IB shows an exemplary coculture experiment that was modified to yield 100% strain detection following coculture.Figures 2A and 2B. Figure 2A shows the design of the DS buckets for a Consortia andFigure 2B shows the yield of strains after coculture depending on the inoculum seed.Figures 3A and 3B. Figures 3A and 3B show examples of different lyophilization excipients.Figures 4A and 4B. Figures 4A and 4B show examples of different lyophilization excipients and reducing agents.Figures 5A and 5B. Figures 5A and 5B show examples of different lyophilization excipients.Figures 6A and 6B. Figure 6A is a venn diagram showing the overlapping microbes of five representative consortia designed and disclosed herein. Figure 6B shows the breakdown of the type of microbe in each of the 5 representative consortia.Figures 7A and 7B. Figures 7A and 7B show the schematics of the experimental designs of the studies described in Example 5.Figure 8. Figure 8 shows that YCFAC + GalNAc is not able to support the growth of Akkermansia.Figure 9. Figure 9 shows that Threonine supports the growth of Akkermansia in the absence of GalNAc.Figure 10. Figure 10 shows a diagram of the coculture method of manufacture of FB-001 and FB-003.Figure 11. Figure 11 shows an overview of the strain isolation and purification process, RCB banking, and RCB identity / purity testing.Figure 12. Figure 12 shows a method for generation of master cell banks (MCB).Figure 13. Figure 13 shows a phylogenetic tree indicating the taxonomic composition of certain of the consortia disclosed herein, including the FB-001 and FB-003 Consortia.Figures 14A-14C. Figures 14A-14C show a table summarizing the strains and species of the microbial consortia disclosed herein.Figures 15A and 15B. Figure 15A shows the effect FB-001 has on reducing gut permeability and Figure 15B shows the ability of FB-001 to produce short chain fatty acids (SCFA) at a level that is comparable to a normal, healthy gut. Butyrate, a SCFA, is important because it supports gastrointestinal epithelial cell health, energy metabolism and cell signaling to improve barrier function. In this experiment, the O. formigenes did not show activity and / or viability and thus the drug product used in these experiments are a research version of FB-003 (i.e., the strains of FB-001 without O. formigenes).Figure 16. Figure 16 shows the manufacturing process used for O. formigenes in the production of the Consortia described herein. Furthermore, DS5-DS7 (i.e., the three O. formigenes drug substances) of FB-001 used this manufacturing process for GMP and non-GMP manufacture.Figure 17. Figure 17 shows the manufacturing process used for DS1 in the production of the Consortia described herein. Furthermore, DS1 of FB-001 used this manufacturing process for GMP and non-GMP manufacture.Figure 18. Figure 18 shows the manufacturing process used for DS2 in the production of the Consortia described herein. Furthermore, DS2 of FB-001 used this manufacturing process for GMP and non-GMP manufacture.Figure 19. Figure 19 shows the manufacturing process used for DS3 in the production of the Consortia described herein. Furthermore, DS3 of FB-001 used this manufacturing process for GMP and non-GMP manufacture.Figure 20. Figure 20 shows the manufacturing process used for DS4 in the production of the Consortia described herein. Furthermore, DS4 of FB-001 used this manufacturing process for GMP and non-GMP manufacture.Figures 21A— 21D. Figure 21 A shows the experimental design for the in vivo assessment for FB-003 engraftment and metabolic function after antibiotic treatment in mice. Figure 2 IB shows that FB-003 has stable engraftment for over 60 days in SPF mice. The “veh” or vehicle used in this experiment was plain media (the term “Media” is used for simplicity in Figure 21A. “abx” stands for antibiotics. The antibiotics (“antibiotics” in Figure 21 A and “abx” in Figure 21B) used in this experiment was 0.575 mg / mL enrofloxacin and Img / mL ampicillin that was provided in the drinking water for 11 days. Figure 21C shows the diverse colonization of of FB-003 based on genus level engraftment. Figure 21D shows the diverse colonization of of FB-003 based on strain level engraftment. The engraftment of FB-003 shown in Figures 21C and 21D is from 1day to 60 days after dosing SPF mice with FB-003 and shows that engraftment stabilizes approximately after 1 week of dosing.Figures 22A-22C Figures 22A-22C show that FB-004 treatment can rapidly produce a modified SCFA profile in mice. Specifically, the total SCFA recovery following microbiome ablating antibiotic treatment (0.575 mg / mL enrofloxacin and Img / mL ampicillin) is faster with FB-003 than with a vehicle control, that FB-003 can control the SCFA profile of the SPF mice, and that the vehicle (i.e., media) treated mice bloom a dysbiotic community dominated by butyrate producers. Figure 22A shows the total SCFA (acetate not included) concentrations following antibiotic treatment in mice + / - FB-003 treatment. Figure 22B shows SCFA levels following antibiotic and FB-003 treatment. Figure 22C shows SCFA levels following antibiotic and vehicle (i.e, media control) treatment. Comparing Figures 22B and 22C show that the ration of SCFAs are different between the FB-003 treatment group and the control group such that butyrate is dominant over proprionate in the control group which is a sign of dysbiosis.Figures 23A and 23B. Figure 23 A shows that antibiotics dramatically disrupt the bile acid pool in the gut. Figure 23B shows that FB-003 rapidly restores balance to the bile acid pool after antibiotic treatment induces dysbiosis.Figures 24A-24G. Figures 24A-24F show the design and results of a DSS colitis mouse model experiment. Figure 24A shows a schematic of the DSS colitis experimental design of the DSS colitis model. Figure 24B shows the experimental design for sample collection and analysis. Figure 24C shows the body weight results of 5% DSS + / - FB-003 in the presence of antibiotic pre-treatment. Figure 24D shows the body weight results of 5% DSS + / - FB-003 in the absence of antibiotic pre-treatment. Figure 24E shows that antibiotics are required to displace a native mouse microbiome, that antibiotic treatment increases DSS colitis severity, and that FB-003 treatment dramatically improves the clinical scores of the mice (and the experiment also showed a reduced weight loss). Figure 24F shows that in the no antibiotic setting, FB-003 still shows improvement in the clinical score (reduced weight loss was also observed). For Figures 24E and 24F, Total Clinical Score was calculated as Area Under the Curve (AUC). Data is presented as mean ±SEM (n=2 or Naive, n=10 per treatment group). Data was analysed by Ordinary One-Way ANOVA followed by Sidak’s multiple comparisons test, the mean of the Abx + FB-003 group was compared to Abx + Vehicle group and the FB-003 treated group compared against the vehicle group. Figure 24G shows the stool consistency score following 5% DSS-induced ulcerative colitis. Specifically, Stool Consistency Score was calculated as Area Under the Curve (AUC). Data is presented as mean ±SEM (n=2 or Naive, n=10 per treatment group). Data was analysed by Ordinary One-Way ANOVA followed by Sidak’s multiple comparisons test, the mean of theAbx + FB-003 group was compared to Abx + Vehicle group and the FB-003 treated group compared against the vehicle group.Figure 25 Figure 25 shows that FB-003 improves survival in the DSS colitis model.Figure 26. Figure 26 provides a chart that provides references that disclose the function of certain species within the Consortia disclosed herein, including FB-003, Consortia A, and Consortia B consortia.Figures 27A-27C. Figure 27A shows clinical scores of the colon of mice in the DSS study described in the examples. Figures 27B and 27C shows images of the colon of mice treated with FB-003 in contrast to vehicle control.DETAILED DESCRIPTIONThe present disclosure relates to compositions and methods for engrafting a microbial consortia disclosed herein. The present disclosure is based, in part, on the discovery that the presently disclosed microbial consortia are capable to effectively engraft in a subject and reduce the dysbiosis, restore the microbiome, and recovery the microbiome of a subject. Furthermore, the present disclosure relates methods of treating IBD, colitis, ulcerative colitis, and Crohn’s disease comprising administering the microbial consortia disclosed herein. For clarity of description, and not by way of limitation, this section is divided into the subsections outlined below.DefinitionsUnless defined otherwise, all technical and scientific terms used herein have the meaning commonly understood by a person skilled in the art. The following references provide one of skill with a general definition of many of the terms used in the presently disclosed subject matter: Singleton et al., Dictionary of Microbiology and Molecular Biology (2nd ed. 1994); The Cambridge Dictionary of Science and Technology (Walker ed., 1988); The Glossary of Genetics, 5th Ed., R. Rieger et al. (eds.), Springer Verlag (1991); and Hale & Marham, The Harper Collins Dictionary of Biology (1991). As used herein, the following terms have the meanings ascribed to them below, unless specified otherwise.It is understood that aspects and embodiments of the present disclosure described herein include “comprising,” “consisting,” and “consisting essentially of’ aspects and embodiments. The terms “comprises” and “comprising” are intended to have the broad meaning ascribed to them in U.S. Patent Law and can mean “includes,” “including” and the like. To facilitate an understanding of the present disclosure, a number of terms and phrases are defined below.The term “a” and “an” as used herein mean “one or more” and include the plural unless the context is appropriate.As used herein, the term “microbe” or “microbiota” refers to a microbial organism including, but not limited to, bacteria, archaea, protozoa, and unicellular fungi.As used herein, the term “active microbes” refers to microbes that express sufficient amounts of one or more metabolic enzymes to metabolize a substrate that causes or contributes to disease in an animal.As used herein, the term “supportive community” refers to one or more microbial strains that, when administered with an active microbe, enhance one or more characteristics of the active microbe selected from the group consisting of gastrointestinal engraftment, biomass, metabolic substrate metabolism, and longitudinal stability.As used herein, the term “synthesizing microbe” refers to a microbe that expresses sufficient amounts of one or more enzymes to catalyze the combination of one or more metabolites produced by an active microbe, and one or more fermentation products produced by a fermenting microbe in a gastrointestinal niche.As used herein, the term “fermenting microbe” refers to a microbe that expresses sufficient amounts of one or more enzymes to catalyze a fermentation reaction in a gastrointestinal niche.As used herein, the term “longitudinal stability” refers to the ability of one or more microbes, or microbial consortia, to remain engrafted and metabolically active in one of more than one niche of the gastrointestinal tract despite transient or long-term environmental changes to the gastrointestinal niche.As used herein, the term “metabolism,” “metabolize,” “metabolization,” or variants thereof refers to the biochemical conversion of a metabolic substrate to a metabolic product. In certain embodiments, metabolization includes isomerization.As used herein, the term “biomass,” refers to the total mass of one or more microbes, or consortia, in a given area or volume.As used herein, the terms “microbial consortia” and “microbial consortium” are used interchangeably and refer to a mixture of two or more isolated microbial strains that are expanded in culture, wherein one microbial strain in the mixture has a beneficial or desired effect on another microbial strain in the mixture.As used herein, the term “Consortia” is used as a capitalized term to refer to one or more of the microbial consortia described herein.As used herein, “dysbiosis” refers to an imbalance in the microbiome homeostasis within internal organs and tissues of a subject (e g., gut) or on the external organs, tissues, and surfaces of the subject (e.g., skin).As used herein, the term “gastrointestinal engraftment” or “engraft” or “engraftment” refers to the establishment of one or more microbes, or microbial consortia, in one or more nichesof the gastrointestinal tract that, prior to administration of the one or more microbes, or microbial consortia, lacks the one or more microbes, or microbial consortia. For clarity, engraftment refers to the engraftment of one or more microbes administered to a subject. In certain embodiments, the gastrointestinal engraftment can be transient. In certain embodiments, the gastrointestinal engraftment can be persistent.As used herein, the term “pharmaceutical composition” refers to the combination of an active agent with a carrier, inert or active, making the composition especially suitable for therapeutic use in vivo or ex vivo.As used herein, the term “pharmaceutically acceptable carrier” refers to any of the standard pharmaceutical carriers, such as phosphate buffered saline solution, water, emulsions (e.g., such as oil / water or water / oil emulsions), and various types of wetting agents. The compositions also can include stabilizers and preservatives. For examples of carriers, stabilizers, and adjuvants, see e.g., Martin, Remington’s Pharmaceutical Sciences, 15thEd. Mack Publ. Co., Easton, PA

[1975] ,As used herein, the term “effective amount” refers to an amount sufficient to achieve a beneficial or desired result. In certain non-limiting embodiments, an effective amount can be an amount that results in improved gastrointestinal engraftment (e.g., engraftment of one or more of the plurality of active microbes), increased biomass (e.g., of one or more of the plurality of active microbes), increased metabolism, or improved longitudinal stability.As used herein, “significantly” or “significant” refers to a change or alteration in a measurable parameter to a statistically significant degree as determined in accordance with an appropriate statistically relevant test. For example, in certain non-limiting embodiments, a change or alteration is significant if it is statistically significant in accordance with, e.g., a Student’s t-test, chi-square, or Mann Whitney test.As used herein, the term “standardized substrate metabolization assay” refers to an experimental assay known to persons of ordinary skill in the art used to quantify the amount of substrate converted to a metabolic product.As used herein, the term “subject” refers to an organism to be treated by the microbial consortium and compositions described herein. Such organisms preferably include, but are not limited to, mammals (e.g., murines, simians, equines, bovines, porcines, canines, felines, and the like), and more preferably include humans.The term percent “identity” or “sequence identity,” in the context of two or more nucleic acid or polypeptide sequences, refer to two or more sequences or subsequences that have a specified percentage of nucleotides or amino acid residues that are the same, when compared and aligned for maximum correspondence, as measured using one of the sequence comparison algorithms described below (e.g., BLASTP and BLASTN or other algorithms available to personsof skill) or by visual inspection. Depending on the application, the percent “identity” can exist over a region of the sequence being compared, e.g., over a functional domain, or, alternatively, exist over the full length of the two sequences to be compared.For sequence comparison, typically one sequence acts as a reference sequence to which test sequences are compared. When using a sequence comparison algorithm, test and reference sequences are input into a computer, subsequence coordinates are designated, if necessary, and sequence algorithm program parameters are designated. The sequence comparison algorithm then calculates the percent sequence identity for the test sequence(s) relative to the reference sequence, based on the designated program parameters.Optimal alignment of sequences for comparison can be conducted, e.g., by the local homology algorithm of Smith & Waterman, Adv. Appl. Math. 2:482 (1981), by the homology alignment algorithm of Needleman & Wunsch, J. Mol. Biol. 48:443 (1970), by the search for similarity method of Pearson & Lipman, Proc. Nat’l. Acad. Sci. USA 85:2444 (1988), by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, Wis.), or by visual inspection (see generally Ausubel et al., infra).One example of an algorithm that is suitable for determining percent sequence identity and sequence similarity is the BLAST algorithm, which is described in Altschul et al., J. Mol. Biol. 215:403-410 (1990). Software for performing BLAST analyses is publicly available through the National Center for Biotechnology Information (www.ncbi.nlm.nih.gov / ).When used in reference to 16S rRNA sequences, a “sequence identity” of at least 97% indicates that two microbial strains are likely to belong to the same species, whereas 16S rRNA sequences having less than 97% sequence identity indicate that two microbial strains likely belong to different species, and 16S rRNA sequences having less than 95% sequence identity indicates that two microbial strains likely belong to distinct genera (Stackebrandt E., and Goebel, B.M., Int J Syst Bact, 44 (1994) 846-849.).As used herein, the terms “functional equivalent” or “functionally equivalent” refers to microbes, microbial consortia, and compositions that share similar or identical role (e.g., metabolism of oxalate). For example, without any limitation, two different microbial consortia that can catalyze high concentration of oxalate are functional equivalent to each other. In certain non-limiting embodiments, a microbe, a microbial consortium, and a composition that is functional equivalent can be based on the characteristic outlined in Table 3 (see Example section).Throughout the description, where compositions are described as having, including, or comprising specific components, or where processes and methods are described as having, including, or comprising specific steps, it is contemplated that, additionally, there arecompositions of the present disclosure that consist essentially of, or consist of, the recited components, and that there are processes and methods according to the present disclosure that consist essentially of, or consist of, the recited processing steps.As a general matter, compositions specifying a percentage are by weight unless otherwise specified. Further, if a variable is not accompanied by a definition, then the previous definition of the variable controls.DysbiosisMicrobiomes are present in multiple species (for example, in mammalian subjects) and comprise bacteria, archaea, protists, fungi, and viruses. Traditionally, a microbiome (e.g., a human microbiome) includes several trillions of microbes (e.g., bacteria) from thousands of species and performs functions that can benefit the host organism (e.g., a human subject). For example, the species present in a microbiome benefit the host (e.g., a human subject) by performing useful or necessary functions, such as aiding in the digestion of food in the intestinal tract of the subject, protecting the body from penetration by pathogenic microbes, and promoting immunological development. In certain embodiments, organisms that perform these functions may be referred to as symbiotic or commensal organisms because they exist in the host (e.g., a human subject) without harming and, in some cases, actually benefit the host. In certain embodiments, in dysbiosis the physiological / normal microbiome of the host (e g., a human subject) is perturbed or damaged, which may lead to a variety of diseases and / or disorders. In certain embodiments, dysbiosis may result, for example, from a loss of beneficial species, loss of microbial diversity, increase in pathogenic organism(s), and / or change in metabolic capacity. In certain embodiments, the species that normally dominate the microbiome become underrepresented (e.g., commensal or symbiotic species) and species which are normally underrepresented (e.g., opportunistic species) become overrepresented. See Petersen et al., “Defining dysbiosis and its influence on host immunity and disease.” Cell Microbiol 2014, July 16 (7), 1024-1033.In certain embodiments, the compositions and methods described herein reduce dysbiosis. In certain embodiments, the compositions and methods provide for an increase in the abundance of bacterial species beneficial to the microbiome. In certain embodiments, the compositions and methods provide for a decrease in the abundance of pathogenic bacterial species. In certain embodiments, the compositions and methods described herein do not reduce all characteristics of dysbiosis. In certain embodiments, the compositions and methods provide for an increase in the abundance of bacterial species beneficial to the microbiome. In certain embodiments, the compositions and methods provide for an increase in the abundance of bacterial species beneficial to the microbiome but do not increase the diversity of the microbiome. In certain embodiments,the term “decreasing dysbiosis” refers to restoring the microbiota community composition and homeostasis. In certain embodiments, disruptions in the microbiome may allow pathogens within the microbiome or from other sources to colonize, overpopulate, and / or cause disease in the subject. In certain embodiments, dysbiosis is associated with many diseases and / or disorders, including inflammatory bowel disease (IBD), colitis, ulcerative colitis, and Crohn’s disease.In certain embodiments, dysbiosis may be detected and / or monitored by many of a variety of methods, such as stool tests (e.g., identification and / or quantification of microbial populations, enzyme assays, metabolite assays, immune function), and / or hydrogen / methane breath tests. Additional methods for detecting dysbiosis encompassed by the present disclosure can be found in Wei et al., Applied and Environmental Microbiology 87, no. 11 (2021): e00395-21, the content of which is incorporated by reference in its entirety.In certain embodiments, decreasing dysbiosis involves a change (e.g., an increase or a decrease) in the abundance of one or more populations of bacteria. In certain embodiments, the abundance of bacteria, including the abundance of specific species or strains of bacteria and abundance of a population of bacteria (e.g., bacteria belonging to a particular phylum) can be assessed using any method known to one of skill in the art. In certain embodiments, the abundance of bacteria can be assessed directly or indirectly. In certain embodiments, methods for directly assessing the abundance of bacteria in a sample (e.g., a microbiome or sample thereof) include identifying and quantifying bacterial strains in a fecal sample from the subject. In certain embodiments, methods for indirectly assessing the abundance of bacteria in a sample (e.g., a microbiome or sample thereof) include sequencing of nucleic acid samples (e.g., 16S rRNA gene for a given bacterial species or other bacterial genes) obtained from a fecal sample or a biopsy sample, and detecting and quantifying metabolites associated with specific bacteria (e.g., phospholipid fatty acid metabolism, microbial biomass carbon analysis) in a fecal sample from the subject.In certain embodiments, the abundance of one or more populations of bacteria in a sample from a subject may be compared to the abundance of the populations of bacteria in a sample from the same subject obtained at another time (e.g., obtained previously or subsequently). In certain embodiments, the abundance of one or more populations of bacteria in a sample from a subject may be compared to the abundance of the populations of bacteria in a sample from a different subject (e.g., a reference subject).In certain embodiments, the dysbiosis is characterized by an increase in the abundance of microorganisms associated with inflammation and / or disease. In certain embodiments, the dysbiosis is characterized by an increase in the abundance of Proteobacteria. In certain embodiments, the increase in the abundance of microorganisms associated with inflammationand / or disease is relative to the abundance of microorganisms associated with inflammation prior to exposure to an event, referred to as a dysbiosis-inducing event.In some embodiments, the dysbiosis of a subject is characterized by a decrease in the abundance of microorganism considered to provide one or more beneficial effects to the subject. In certain embodiments, the dysbiosis is characterized by a decrease in the abundance of bacteria of the phylum Bacteroidetes. In certain embodiments, the dysbiosis of the microbiota of a subject is characterized by a decrease in the abundance of bacteria of the phylum Firmicutes. In certain embodiments, the dysbiosis is characterized by a decrease in the abundance of bacteria belonging to Clostridium clusters IV and / or Clostridium clusters XlVa. In certain embodiments, the dysbiosis is characterized by a decrease in the abundance of bacteria belonging to Clostridium cluster XVII. In certain embodiments, the decrease in the abundance of beneficial microorganisms is relative to the abundance of microorganisms associated with inflammation prior to exposure to an event, referred to as a dysbiosis-inducing event, as described herein.In certain embodiments, the dysbiosis is a dysbiosis of the gastrointestinal microbiota. In certain embodiments, the dysbiosis of the gastrointestinal microbiota is characterized by an increase in the abundance of microorganisms associated with inflammation and / or disease. In certain embodiments, the dysbiosis of the gastrointestinal microbiota is characterized by an increase in the abundance of Proteobacteria. In certain embodiments, the increase in the abundance of microorganisms associated with inflammation and / or disease is relative to the abundance of microorganisms associated with inflammation prior to exposure to an event (e.g., a dysbiosis-inducing event).In certain embodiments, the dysbiosis of the gastrointestinal microbiota is characterized by a decrease in the abundance of microorganism considered to provide one or more beneficial effects to the subject. In certain embodiments, the dysbiosis of the gastrointestinal microbiota is characterized by a decrease in the abundance of bacteria of the phylum Bacteroidetes. In certain embodiments, the dysbiosis of the gastrointestinal microbiota is characterized by a decrease in the abundance of bacteria of the phylum Firmicutes. In certain embodiments, the dysbiosis of the gastrointestinal microbiota is characterized by a decrease in the abundance of bacteria belonging to Clostridium clusters IV and / or Clostridium clusters XlVa. In certain embodiments, the dysbiosis of the gastrointestinal microbiota is characterized by a decrease in the abundance of bacteria belonging to Clostridium cluster XVH. In certain embodiments, the decrease in the abundance of beneficial microorganisms is relative to the abundance of microorganisms associated with inflammation prior to exposure to an event (e.g., a dysbiosis-inducing event).In certain embodiments, decreasing dysbiosis results in an increase in the abundance of bacteria of the phylum Bacteroidetes (e.g., bacteria of the genus Bacteroides) relative to theabundance of Bacteroides in the host (e.g., a human subject) (or microbiome thereof) prior to administering the pharmaceutical composition. In certain embodiments, decreasing dysbiosis results in an increase in the abundance of bacteria of the phylum Bacteroidetes (e g., bacteria of the genus Bacteroides) relative to the abundance of Bacteroides in a reference host (e.g., a human subject, e.g., a reference subject) (or microbiome thereof) who did not receive the pharmaceutical composition. In certain embodiments, decreasing dysbiosis results in an increase in the abundance of one or more bacterial species belonging to the genus Bacteroides. In certain embodiments, decreasing dysbiosis results in an increase in the abundance overall of bacterial species belonging to the genus Bacteroides.Biological NichesDisclosed herein are microbial consortia for administration to an animal (e.g., a human subject) comprising a plurality of active microbes which metabolize a first metabolic substrate. In certain embodiments, the first metabolic substrate causes or contributes to disease in the animal. The microbial consortia disclosed herein further comprise an effective amount of a supportive community of microbes that metabolize one or more metabolites produced by the plurality of active microbes, wherein the one or more metabolites inhibit metabolism of the plurality of active microbes. These microbial consortia are advantageous in having enhanced characteristics when administered to an animal as compared to administration of the plurality of active microbes alone. Enhanced characteristics of the microbial consortia include, for example and without any limitation, improved gastrointestinal engraftment, increased biomass, increased metabolism of the first metabolic substrate, and improved longitudinal stability.The present disclosure provides microbial consortia capable of engrafting into one or more niches of a gastrointestinal tract. In certain embodiments, the engrafted microbial consortia are capable of metabolizing a substrate that causes or contributes to disease in an animal. These niches comprise specific microbial communities whose composition varies according to a number of environmental factors including, but not limited to, the particular physical compartment of the gastrointestinal tract inhabited by a microbial community, the chemical and physicochemical properties of the environment inhabited, the metabolic substrate composition of the environment inhabited, and other co-inhabiting microbial species.ConsortiaThe present disclosure provides Consortia comprising a plurality of active microbes and an effective amount of a supportive community of microbes.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia I.” In certain embodiments, the Consortia I comprises Acidaminococcus intestini, Bacteroides stercoris,Blautia hydrogenotrophica, Coprococcus eutactus, Holdemanella biformis, Akkermansia muciniphila, Bacteroides stercoris, Blautia luti, Coprococcus eutactus, Holdemanella biformis, Alistipes fmegoldii, Bacteroides thetaiotaomicron, Blautia luti, Desulfovibrio desulfuricans, Hungatella hathewayi, Alistipes onderdonkii, Bacteroides thetaiotaomicron, Blautia luti, Desulfovibrio desulfuricans, Hungatella hathewayi, Alistipes onderdonkii, Bacteroides thetaiotaomicron, Blautia obeum, Dialister invisus, Neglecta timonensis, Alistipes onderdonkii, Bacteroides uniformis, Blautia obeum, Dorea formicigenerans, Oxalobacter formigenes, Alistipes putredinis, Bacteroides uniformis, Blautia obeum, Dorea formicigenerans, Oxalobacter formigenes, Alistipes putredinis, Bacteroides uniformis, Blautia obeum, Dorea formicigenerans, Oxalobacter formigenes, Alistipes senegalensis, Bacteroides uniformis, Blautia wexlerae, Dorea longicatena, Parabacteroides distasonis, Alistipes senegalensis, Bacteroides vulgatus, Blautia wexlerae, Dorea longicatena, Parabacteroides distasonis, Alistipes shahii, Bacteroides vulgatus, Blautia wexlerae, Dorea longicatena, Parabacteroides distasonis, Alistipes shahii, Bacteroides vulgatus, Clostridium aldenense, Eggerthella lenta, Parabacteroides merdae, Alistipes shahii, Bacteroides vulgatus, Clostridium aldenense, Eggerthella lenta, Parabacteroides merdae, Alistipes timonensis, Bacteroides xylanisolvens, Clostridium amygdalinum, Eggerthella lenta, Parabacteroides merdae, Anaerofustis stercorihominis, Bacteroides xylanisolvens, Clostridium bolteae, Eggerthella lenta, Paraprevotella clara, Anaerostipes hadrus, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium eligens, Parasutter el la excrementihominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Clostridium citroniae, Eubacterium eligens, Parasutterella excrementihominis, Anaerotruncus colihominis, Bifidobacterium adolescentis, Clostridium citroniae, Eubacterium eligens, Roseburia hominis, Bacteroides caccae, Bifidobacterium catenulatum, Clostridium scindens, Eubacterium eligens, Roseburia hominis, Bacteroides caccae, Bifidobacterium dentium, Clostridium symbiosum, Eubacterium hallii, Roseburia hominis, Bacteroides cellulosilyticus, Bifidobacterium longum, Clostridium symbiosum, Eubacterium rectale, Roseburia hominis, Bacteroides coprocola, Bifidobacterium longum, Clostridium symbiosum, Eubacterium rectale, Ruminococcus bromii, Bacteroides finegoldii, Bifidobacterium longum, Collinsella aerofaciens, Eubacterium rectale, Ruminococcus bromii, Bacteroides fragilis, Bifidobacterium longum, Collinsella aerofaciens, Eubacterium rectale, Ruminococcus bromii, Bacteroides massiliensis, Bifidobacterium pseudocatenulatum, Collinsella aerofaciens, Eubacterium siraeum, Ruminococcus bromii, Bacteroides massiliensis, Bifidobacterium pseudocatenulatum, Collinsella aerofaciens, Eubacterium ventriosum, Ruminococcus faecis, Bacteroides nordii, Bifidobacterium pseudocatenulatum, Coprococcus comes, Eubacterium xylanophilum, Ruminococcus faecis, Bacteroides oleiciplenus, Blautia faecis, Coprococcus comes, Faecalibacterium prausnitzii, Turicibacter sanguinis, Bacteroides ovatus, Blautia faecis,Coprococcus comes, Faecalibacterium prausnitzii, Bacteroides salyersiae, Blautia faecis, Coprococcus comes, Gordonibacter pamelaeae, Bacteroides stercoris, Blautia faecis, Coprococcus eutactus, and Gordonibacter pamelaeae.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia II.” In certain embodiments, the Consortia II comprises Akkermansia muciniphila, Bacteroides vulgatus, Clostridium amygdalinum, Eggerthella lenta, Oxalobacter formigenes, Alistipes onderdonkii, Bifidobacterium dentium, Clostridium citroniae, Eubacterium eligens, Parabacteroides distasonis, Alistipes putredinis, Bifidobacterium faecale, Clostridium citroniae, Eubacterium eligens, Parabacteroides distasonis, Alistipes shahii, Bifidobacterium longum, Clostridium scindens, Eubacterium rectale, Parabacteroides merdae, Alistipes timonensis, Bifidobacterium longum, Clostridium symbiosum, Eubacterium rectale, Paraprevotella clara, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Collinsella aerofaciens, Faecalibacterium prausnitzii, Parasutterella excrementihominis, Bacteroides koreensis, Bifidobacterium pseudocatenulatum, Coprococcus comes, Fusicatenibacter saccharivorans, Phascolarctobacterium faecium, Bacteroides kribbi, Bifidobacterium pseudocatenulatum, Coprococcus eutactus, Fusicatenibacter saccharivorans, Phascolarctobacterium faecium, Bacteroides kribbi, Blautia faecis, Desulfovibrio desulfuricans, Gordonibacter pamelaeae, Phascolarctobacterium faecium, Bacteroides nordii, Blautia faecis, Dialister succinatiphilus, Lachnoclostridium pacaense, Roseburia hominis, Bacteroides ovatus, Blautia obeum, Dorea formicigenerans, Lachnospira pectinoschiza, Ruminococcus bromii, Bacteroides salyersiae, Blautia obeum, Dorea longicatena, Monoglobus pectinilyticus, Ruminococcus bromii, Bacteroides thetaiotaomicron, Blautia obeum, Eggerthella lenta, Neglecta timonensis, Ruminococcus faecis, Bacteroides thetaiotaomicron, Blautia wexlerae, Eggerthella lenta, Oxalobacter formigenes, Sutter ellamassiliensis, Bacteroides uniformis, Blautia wexlerae, Eggerthella lenta, Oxalobacter formigenes, and Sutterella wadsw orthensis.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia III.” In certain embodiments, the Consortia III comprises Akkermansia muciniphila, Bacteroides vulgatus, Clostridium scindens, Eubacterium rectale, Parabacteroides merdae, Anaerotruncus colihominis, Bacteroides vulgatus, Clostridium symbiosum, Eubacterium rectale, Ruminococcus bromii, Bacteroides caccae, Bacteroides vulgatus, Clostridium symbiosum, Eubacterium rectale, Ruminococcus bromii, Bacteroides caccae, Bifidobacterium adolescentis, Clostridium symbiosum, Eubacterium rectale, Ruminococcus bromii, Bacteroides cellulosilyticus, Bifidobacterium adolescentis, Collinsella aerofaciens, Eubacterium siraeum, Ruminococcusbromii, Bacteroides fragilis, Bifidobacterium bifidum, Collinsella aerofaciens, Faecalibacterium prausnitzii, Sutterella wadsworthensis, Bacteroides massiliensis, Bifidobacterium bifidum, Collinsella aerofaciens, Gordonibacter pamelaeae, Sutterella wadsworthensis, Bacteroides massiliensis, Bifidobacterium catenulatum, Collinsella aerofaciens, Gordonibacter pamelaeae, Sutterella wadsworthensis, Bacteroides salyersiae, Bifidobacterium dentium, Coprococcus comes, Hydrogenoanaerobacterium saccharovorans, Bacteroides vulgatus, Bacteroides ster coris, Bifidobacterium longum, Coprococcus comes, Lachnospiraceae sp., Clostridium citroniae, Bacteroides stercoris, Bifidobacterium longum, Coprococcus comes, Lactonifactor longoviformis, Eggerthella lenta, Bacteroides stercoris, Bifidobacterium longum, Desulfovibrio desulfuricans, Neglecta timonensis, Parabacteroides merdae, Bacteroides thetaiotaomicron, Bifidobacterium longum, Desulfovibrio desulfuricans, Oxalobacter formigenes, Parabacteroides merdae, Bacteroides thetaiotaomicron, Bifidobacterium pseudocatenulatum, Dorea longicatena, Oxalobacter formigenes, Eggerthella lenta, Bacteroides thetaiotaomicron, Bifidobacterium pseudocatenulatum, Dorea longicatena, Oxalobacter formigenes, Clostridium citroniae, Bacteroides uniformis, Bifidobacterium pseudocatenulatum, Dorea longicatena, Parabacteroides distasonis, Bacteroides uniformis, Bacteroides uniformis, Citrobacter freundii, Eggerthella lenta, Parabacteroides distasonis, Bacteroides uniformis, Clostridium amygdalinum, Eggerthella lenta, and Parabacteroides distasonis.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia IV.” In certain embodiments, the Consortia IV comprises Alistipes finegoldii, Bacteroides vulgatus, Clostridium bolteae, Dorea longicatena, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium bolteae, Eggerthella lenta, Parabacteroides merdae Alistipes putredinis, Bacteroides xylanisolvens, Clostridium citroniae, Eggerthella lenta, Parabacteroides merdae, Anaerotruncus colihominis, Bacteroides xylanisolvens, Clostridium citroniae, Eggerthella lenta, Parabacteroides merdae, Bacteroides caccae, Bacteroides xylanisolvens, Clostridium scindens, Eggerthella lenta, Ruminococcus bromii, Bacteroides cellulosilyticus, Bifidobacterium bifidum, Clostridium symbiosum, Eubacterium eligens, Ruminococcus bromii, Bacteroides coprocola, Bifidobacterium bifidum, Clostridium symbiosum, Eubacterium eligens, Ruminococcus bromii, Bacteroides fragilis, Bifidobacterium catenulatum, Clostridium symbiosum, Eubacterium eligens, Ruminococcus bromii, Bacteroides ovatus, Bifidobacterium dentium, Collinsella aerofaciens, Eubacterium eligens, Sutterella wadsworthensis, Bacteroides salyersiae, Bifidobacterium longum, Collinsella aerofaciens, Eubacterium hallii, Bacteroides stercoris, Bifidobacterium longum, Collinsella aerofaciens, Eubacterium rectale, Bacteroides stercoris, Bifidobacterium longum, Collinsella aerofaciens, Eubacterium siraeum, Bacteroides stercoris, Bifidobacteriumlongum, Coprococcus comes, Eubacterium ventriosum, Bacteroides thetaiotaomicron, Bifidobacterium pseudocatenulatum, Coprococcus eutactus, Faecalibacterium prausnitzii, Bacteroides thetaiotaomicron, Bifidobacterium pseudocatenulatum, Coprococcus eutactus, Faecalibacterium prausnitzii, Bacteroides thetaiotaomicron, Bifidobacterium pseudocatenulatum, Coprococcus eutactus, Hungatella hathewayi, Bacteroides uniformis, Blautia hydrogenotrophica, Desulfovibrio desulfuricans, Hungatella hathewayi, Bacteroides uniformis, Blautia obeum, Desulfovibrio desulfuricans, Neglecta timonensis, Bacteroides vulgatus, Blautia obeum, Dorea formicigenerans, Oxalobacter formigenes, Bacteroides vulgatus, Clostridium amygdalinum, Dorea longicatena, and Oxalobacter formigenes.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia V.” In certain embodiments, the Consortia V comprises Acidaminococcus intestini, Bacteroides uniformis, Clostridium citroniae, Eubacterium ventriosum, Phascolarctobacterium faecium, Akkermansia muciniphila, Bacteroides vulgatus, Clostridium clostridioforme, Eubacterium siraeum, Phascolarctobacterium faecium, Alistipes finegoldii, Bacteroides vulgatus, Clostridium scindens, Eubacterium xylanophilum, Phocea massiliensis, Alistipes onderdonkii, Bacteroides xylanisolvens, Clostridium swellfunianum, Faecalibacterium prausnitzii, Phocea massiliensis, Alistipes onderdonkii, Bacteroides xylanisolvens, Clostridium symbiosum, Faecalibacterium prausnitzii, Porphyromonas asaccharolytica, Alistipes putredinis, Barnesiella intestinihominis, Clostridium symbiosum, Faecalicatena contorta, Porphyromonas asaccharolytica, Alistipes putredinis, Bifidobacterium adolescentis, Collinsella aerofaciens, Fusicatenibacter saccharivorans, Roseburia hominis, Alistipes senegalensis, Bifidobacterium adolescentis, Collinsella aerofaciens, Fusicatenibacter saccharivorans, Roseburia hominis, Alistipes senegalensis, Bifidobacterium bifidum, Coprococcus comes, Gordonibacter pamelaeae, Ruminococcus bromii, Alistipes shahii, Bifidobacterium bifidum, Coprococcus comes, Gordonibacter pamelaeae, Ruminococcus bromii, Alistipes timonensis, Bifidobacterium catenulatum, Coprococcus eutactus, Holdemanella biformis, Ruminococcus faecis, Anaerofustis stercorihominis, Bifidobacterium dentium, Coprococcus eutactus, Holdemanella biformis, Ruminococcus faecis, Anaerostipes hadrus, Bifidobacterium faecale, Desulfovibrio desulfuricans, Hungatella effluvii, Ruthenibacterium lactatiformans, Anaerostipes hadrus, Bifidobacterium longum, Desulfovibrio desulfuricans, Hungatella hathewayi, Senegalimassilia anaerobia, Anaerotruncus colihominis, Bifidobacterium longum, Dialister invisus, Hungatella hathewayi, Sutterella massiliensis, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dialister succinatiphilus, Hydrogenoanaerobacterium saccharovorans, Sutterella wadsworthensis, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Lachnoclostridiumpacaense, Sutter ella wadsworthensis, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Lachnoclostridium pacaense, Turicibacter sanguinis, Bacteroides faecis, Blautia faecis, Dorea formicigenerans, Lachnospira pectinoschiza, Bacteroides finegoldii, Blautia faecis, Dorea longicatena, Lachnospira pectinoschiza, Bacteroides fragilis, Blautia hydrogenotrophica, Dorea longicatena, Lactonifactor longoviformis, Bacteroides koreensis, Blautia luti, Eggerthella lenta, Longicatena caecimuris, Bacteroides koreensis, Blautia obeum, Eggerthella lenta, Megasphaera massiliensis, Bacteroides kribbi, Blautia obeum, Eggerthella lenta, Monoglobus pectinilyticus, Bacteroides kribbi, Blautia wexlerae, Eggerthella lenta, Monoglobus pectinilyticus, Bacteroides massiliensis, Blautia wexlerae, Eisenbergiella tayi, Neglecta timonensis, Bacteroides nordii, Butyricimonas faecihominis, Eisenbergiella tayi, Oxalobacter formigenes, Bacteroides oleiciplenus, Catabacter hongkongensis, Emergencia timonensis, Oxalobacter formigenes, Bacteroides ovatus, Citrobacter freundii, Eubacterium eligens, Oxalobacter formigenes, Bacteroides salyersiae, Clostridium aldenense, Eubacterium eligens, P ar abacter aides distasonis, Bacteroides stercoris, Clostridium aldenense, Eubacterium hallii, Parabacteroides merdae, Bacteroides stercoris, Clostridium amygdalinum, Eubacterium oxidoreducens, Parabacteroides merdae, Bacteroides thetaiotaomicron, Clostridium bolteae, Eubacterium rectale, Paraprevotella clara, Bacteroides thetaiotaomicron, Clostridium bolteae, Eubacterium rectale, Parasutterella excrementihominis, Bacteroides uniformis, Clostridium citroniae, Eubacterium ruminantium, and Parasutterella excrementihominis.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia VI.” In certain embodiments, the Consortia VI comprises Acidaminococcus intestini, Bacteroides stercorirosoris, Butyricimonas sp. FBI00158, Enterococcus casseliflavus, Longicatena caecimuri, Acidaminococcus intestini, Bacteroides stercoris, Catabacter hongkongensis, Enterococcus casseliflavus, Megasphaera massiliensis, Acutalibacter timonensis, Bacteroides stercoris, Citrobacter portucalensis, Enterococcus durans, Methanobrevibacter smithii, Akkermansia muciniphila, Bacteroides thetaiotaomicron, Clostridiaceae sp. FBI00191, Enterococcus durans, Monoglobus pectinilyticus, Alistipes onderdonkii, Bacteroides thetaiotaomicron, Clostridium aldenense, Enterococcus durans, Monoglobus pectinilyticus, Alistipes onderdonkii, Bacteroides uniformis, Clostridium aldenense, Enterococcus faecalis, Oxalobacter formigenes, Alistipes putredinis, Bacteroides uniformis, Clostridium bolteae, Enterococcus f aecium, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium bolteae, Escherichia flexneri, Oxalobacter formigenes, Alistipes senegalensis, Bacteroides vulgatus, Clostridium citroniae, Eubacterium eligens, Parabacteroides distasonis,Alistipes shahii, Bacteroides xylanisolvens, Clostridium citroniae, Eubacterium eligens, Parabacteroides distasonis, Alistipes shahii, Bacteroides xylanisolvens, Clostridium clostridioforme, Eubacterium hallii, Parabacteroides merdae, Alistipes sp. FBI00180, Bacteroides xylanisolvens, Clostridium fessum, Eubacterium rectale, Parabacteroides merdae, Alistipes sp. FBI00238, Barnesiella intestinihominis, Clostridium fessum, Eubacterium rectale, Paraprevotella clara, Alistipes timonensis, Bifidobacterium adolescentis, Clostridium scindens, Eubacterium siraeum, Parasutterella excrementihominis, Anaerofustis stercorihominis, Bifidobacterium adolescentis, Collinsella aerofaciens, Eubacterium ventriosum, Parasutterella excrementihominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Collinsella aerofaciens, Eubacterium xylanophilum, Phascolarctobacterium faecium, Anaerostipes hadrus, Bifidobacterium adolescentis, Coprococcus comes, Faecalibacterium prausnitzii, Phascolarctobacterium faecium, Anaerotruncus massiliensis, Bifidobacterium bifidum, Coprococcus comes, Faecalibacterium prausnitzii, Porphyromonas asaccharolytica, Bacteroides caccae, Bifidobacterium bifidum, Coprococcus eutactus, Faecalicatena contorta, Porphyromonas asaccharolytica, Bacteroides caccae, Bifidobacterium catenulatum, Dialister invisus, Fusicatenibacter saccharivorans, Roseburia hominis, Bacteroides cellulosilyticus, Bifidobacterium dentium, Coprococcus eutactus, Fusicatenibacter saccharivorans, Roseburia hominis, Bacteroides cellulosilyticus, Bifidobacterium longum, Dialister succinatiphilus, Gordonibacter pamelaeae, Ruminococcaceae sp. FBI00097, Bacteroides coprocola, Bifidobacterium longum, Dialister succinatiphilus, Gordonibacter pamelaeae, Ruminococcaceae sp. FBI00097, Bacteroides dorei, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Holdemanella biformis, Ruminococcaceae sp. FBI00233, Bacteroides dorei, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Holdemanella biformis, Ruminococcus bromii, Bacteroides faecis, Bilophila wadsworthia, Dorea formicigenerans, Hungatella effluvii, Ruminococcus bromii, Bacteroides finegoldii, Bilophila wadsworthia, Dorea longicatena, Hungatella effluvii, Ruminococcus faecis, Bacteroides fragilis, Blautia faecis, Dorea longicatena, Hungatella effluvii, Ruminococcus faecis, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia faecis, Eggerthella lenta, Lachnoclostridium pacaense, Ruthenibacterium lactatif ormans, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia hydrogenotrophica, Eggerthella lenta, Lachnoclostridium pacaense, Senegalimassilia anaerobia, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia luti, Eisenbergiella tayi, Lachnospiraceae sp. FBI00033, Sutterella massiliensis, Bacteroides massiliensis, Blautia massiliensis, Emergencia timonensis, Lachnospiraceae sp. FBI00071, Sutterella wadsworthensis, Bacteroides massiliensis, Blautia obeum, Eisenbergiella tayi, Lachnospiraceae sp. FBI00150, Sutterella wadsworthensis, Bacteroides nordii, Blautia obeum, Enterobacter himalayensis,Lachnospiraceae sp. FBI00290, Turicibacter sanguinis, Bacteroides ovatus, Blautia wexlerae, Enterobacter hormaechei, Lactobacillus rogosae, Bacteroides salyersiae, Blautia wexlerae, Enterococcus casseliflavus, Lactobacillus rogosae, Bacteroides salyersiae, Butyricimonas faecihominis, Enterococcus casseliflavus, and Lactonifactor longoviformis .In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia VII.” In certain embodiments, the Consortia VII comprises Acidaminococcus intestini, Bacteroides thetaiotaomicron, Citrobacter portucalensis, Eubacterium eligens, Oxalobacter formigenes, Acutalibacter timonensis, Bacteroides uniformis, Clostridiaceae sp. FBI00191, Eubacterium hallii, Parabacteroides distasonis, Akkermansia muciniphila, Bacteroides uniformis, Clostridium aldenense, Eubacterium rectale, Parabacteroides merdae, Alistipes onderdonkii, Bacteroides vulgatus, Clostridium aldenense, Eubacterium rectale, Parabacteroides merdae, Alistipes onderdonkii, Bacteroides vulgatus, Clostridium bolteae, Eubacterium siraeum, Paraprevotella clara, Alistipes putredinis, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium ventriosum, Parasutterella excrementihominis, Alistipes putredinis, Bacteroides xylanisolvens, Clostridium citroniae, Faecalibacterium prausnitzii, Parasutterella excrementihominis, Alistipes senegalensis, Bacteroides xylanisolvens, Clostridium citroniae, Eubacterium xylanophilum, Phascolarctobacterium faecium, Alistipes shahii, Barnesiella intestinihominis, Clostridium clostridioforme, Faecalibacterium prausnitzii, Phascolarctobacterium faecium, Alistipes sp. FBI00180, Bifidobacterium adolescentis, Clostridium fessum, Faecalicatena contorta, Porphyromonas asaccharolytica, Alistipes sp. FBI00238, Bifidobacterium adolescentis, Clostridium fessum, Fusicatenibacter saccharivorans, Porphyromonas asaccharolytica, Alistipes timonensis, Bifidobacterium adolescentis, Clostridium scindens, Fusicatenibacter saccharivorans, Roseburia hominis, Anaerofustis stercorihominis, Bifidobacterium bifidum, Collinsella aerofaciens, Gordonibacter pamelaeae, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium bifidum, Collinsella aerofaciens, Gordonibacter pamelaeae, Ruminococcaceae sp. FBI00097, Anaerostipes hadrus, Bifidobacterium catenulatum, Coprococcus comes, Holdemanella biformis, Ruminococcaceae sp. FBI00097, Anaerotruncus massiliensis, Bifidobacterium dentium, Coprococcus comes, Holdemanella biformis, Ruminococcaceae sp. FBI00233, Bacteroides caccae, Bifidobacterium longum, Coprococcus eutactus, Hungatella effluvii, Ruminococcus bromii, Bacteroides caccae, Bifidobacterium longum, Coprococcus eutactus, Hungatella effluvii, Ruminococcus bromii, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dialister invisus, Hungatella effluvii, Ruminococcus faecis, Bacteroides faecis, Bifidobacterium pseudocatenulatum, Dialister succinatiphilus, Lachnoclostridium pacaense, Ruminococcus faecis, Bacteroides finegoldii, Bifidobacterium pseudocatenulatum,Dielma fastidiosa, Lachnoclostridium pacaense, Ruthenibacterium lactatif ormans, Bacteroides fragilis, Bilophila wadsworthia, Dorea formicigenerans, Lachnospiraceae sp. FBI00033, Senegalimassilia anaerobia, Bacteroides kribbi / Bacteroides koreensis species cluster, Bilophila wadsworthia, Dorea formicigenerans, Lachnospiraceae sp. FBI00071, Sutterella massiliensis, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia faecis, Dorea longicatena, Lachnospiraceae sp. FBI00290, Sutterella wadsworthensis, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia faecis, Dorea longicatena, Lactobacillus rogosae, Sutterella wadsworthensis, Bacteroides massiliensis, Blautia hydrogenotrophica, Eggerthella lenta, Lactobacillus rogosae, Turicibacter sanguinis, Bacteroides nordii, Blautia massiliensis, Eggerthella lenta, Lactonifactor longoviformis, Bacteroides ovatus, Blautia obeum, Eggerthella lenta, Longicatena caecimuris, Bacteroides salyersiae, Blautia obeum, Eggerthella lenta, Megasphaera massiliensis, Bacteroides stercorirosoris, Blautia wexlerae, Eisenbergiella tayi, Monoglobus pectinilyticus, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, Monoglobus pectinilyticus, Bacteroides stercoris, Butyricimonas faecihominis, Emergencia timonensis, Oxalobacter formigenes, Bacteroides thetaiotaomicron, Catabacter hongkongensis, Eubacterium eligens, and Oxalobacter formigenes.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia VIII.” In certain embodiments, the Consortia VIII comprises Acidaminococcus intestini, Bacteroides thetaiotaomicron, Butyricimonas faecihominis, Eisenbergiella tayi, Monoglobus pectinilyticus, Acutalibacter timonensis, Bacteroides thetaiotaomicron, Catabacter hongkongensis, Emergencia timonensis, Monoglobus pectinilyticus, Akkermansia muciniphila, Bacteroides uniformis, Citrobacter portucalensis, Eubacterium eligens, Oxalobacter formigenes, Alistipes onderdonkii, Bacteroides uniformis, Clostridiaceae sp. FBI00191, Eubacterium eligens, Oxalobacter formigenes, Alistipes onderdonkii, Bacteroides vulgatus, Clostridium aldenense, Eubacterium hallii, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium aldenense, Eubacterium rectale, Parabacteroides distasonis, Alistipes putredinis, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium rectale, Parabacteroides merdae, Alistipes senegalensis, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium siraeum, Parabacteroides merdae, Alistipes shahii, Bacteroides xylanisolvens, Clostridium citroniae, Eubacterium ventriosum, Paraprevotella clara, Alistipes sp. FBI00180, Barnesiella intestinihominis, Clostridium citroniae, Faecalibacterium prausnitzii, Parasutterella excrementihominis, Alistipes sp. FBI00238, Bifidobacterium adolescentis, Clostridium clostridioforme, Eubacterium xylanophilum, Parasutterella excrementihominis, Alistipes timonensis, Bifidobacterium adolescentis, Clostridium fessum, Faecalibacterium prausnitzii, Phascolarctobacterium faecium, Anaerofustisstercorihominis, Bifidobacterium adolescentis, Clostridium fessum, Faecalicatena contorta, Phascolarctobacterium faecium, Anaerostipes hadrus, Bifidobacterium bifidum, Clostridium scindens, Fusicatenibacter saccharivorans, Porphyromonas asaccharolytica, Anaerostipes hadrus, Bifidobacterium bifidum, Collinsella aerofaciens, Fusicatenibacter saccharivorans, Porphyromonas asaccharolytica, Anaerotruncus massiliensis, Bifidobacterium catenulatum, Collinsella aerofaciens, Gordonibacter pamelaeae, Roseburia hominis, Bacteroides caccae, Bifidobacterium dentium, Coprococcus comes, Gordonibacter pamelaeae, Roseburia hominis, Bacteroides caccae, Bifidobacterium longurn, Coprococcus comes, Holdemanella biformis, Ruminococcaceae sp. FBI00097, Bacteroides coprocola, Bifidobacterium longum, Coprococcus eutactus, Holdemanella biformis, Ruminococcaceae sp. FBI00097, Bacteroides faecis, Bifidobacterium pseudocatenulatum, Coprococcus eutactus, Hungatella effluvii, Ruminococcaceae sp. FBI00233, Bacteroides finegoldii, Bifidobacterium pseudocatenulatum, Dialister invisus, Hungatella effluvii, Ruminococcus bromii, Bacteroides fragilis, Bifidobacterium pseudocatenulatum, Dialister succinatiphilus, Hungatella effluvii, Ruminococcus bromii, Bacteroides kribbi / Bacteroides koreensis species cluster, Bilophila wadsworthia, Dielma fastidiosa, Lachnoclostridium pacaense, Ruminococcus faecis, Bacteroides kribbi / Bacteroides koreensis species cluster, Bilophila wadsworthia, Dorea formicigenerans, Lachnoclostridium pacaense, Ruminococcus faecis, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia faecis, Dorea formicigenerans, Lachnospiraceae sp. FBI00033, Ruthenibacterium lactatif ormans, Bacteroides massiliensis, Blautia faecis, Dorea longicatena, Lachnospiraceae sp. FBI00071, Senegalimassilia anaerobia, Bacteroides nordii, Blautia hydrogenotrophica, Dorea longicatena, Lachnospiraceae sp. FBI00290, Sutterella massiliensis, Bacteroides ovatus, Blautia massiliensis, Eggerthella lenta, Lactobacillus rogosae, Sutterella wadsworthensis, Bacteroides salyersiae, Blautia obeum, Eggerthella lenta, Lactobacillus rogosae, Sutterella wadsworthensis, Bacteroides stercorirosoris, Blautia obeum, Eggerthella lenta, Lactonifactor longoviformis, Turicibacter sanguinis, Bacteroides stercoris, Blautia wexlerae, Eggerthella lenta, Longicatena caecimuris, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, and Megasphaera massiliensis.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia IX.” In certain embodiments, the Consortia XI comprises Acidaminococcus intestini, Bacteroides thetaiotaomicron, Butyricimonas faecihominis, Eubacterium eligens, Neglecta timonensis, Akkermansia muciniphila, Bacteroides thetaiotaomicron, Catabacter hongkongensis, Eubacterium eligens, Oxalobacter formigenes, Alistipes onderdonkii, Bacteroides uniformis, Clostridiaceae sp. FBI00191, Eubacterium hallii, Oxalobacter formigenes, Alistipes onderdonkii,Bacteroides uniformis, Clostridiales sp. FBI00377, Eubacterium rectale, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium aldenense, Eubacterium rectale, Parabacteroides distasonis, Alistipes putredinis, Bacteroides vulgatus, Clostridium aldenense, Eubacterium siraeum, Parabacteroides distasonis, Alistipes senegalensis, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium ventriosum, Parabacteroides merdae, Alistipes shahii, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium xylanophilum, Parabacteroides merdae, Alistipes shahii, Bacteroides xylanisolvens, Clostridium citroniae, Faecalibacterium prausnitzii, Paraprevotella clara, Alistipes sp. FBI00180, Barnesiella intestinihominis, Clostridium citroniae, Fusicatenibacter saccharivorans, Parasutterella excrementihominis, Alistipes sp. FBI00238, Bifidobacterium adolescentis, Clostridium clostridioforme, Fusicatenibacter saccharivorans, Parasutterella excrementihominis, Alistipes timonensis, Bifidobacterium adolescentis, Clostridium fessum, Gordonibacter pamelaeae, Phascolarctobacterium faecium, Anaerofustis stercorihominis, Bifidobacterium adolescentis, Clostridium scindens, Gordonibacter pamelaeae, Porphyromonas asaccharolytica, Anaerostipes hadrus, Bifidobacterium bifidum, Collinsella aerofaciens, Holdemanella biformis, Porphyromonas asaccharolytica, Anaerostipes hadrus, Bifidobacterium catenulatum, Collinsella aerofaciens, Hungatella effluvii, Roseburia hominis, Anaerotruncus massiliensis, Bifidobacterium dentium, Coprococcus comes, Hungatella effluvii, Roseburia hominis, Bacteroides caccae, Bifidobacterium longum, Coprococcus comes, Hungatella effluvii, Ruminococcaceae sp. FBI00082, FBI00097, Bacteroides caccae, Bifidobacterium longum, Coprococcus eutactus, Lachnoclostridium pacaense, Ruminococcaceae sp. FBI00233, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dialister invisus, Lachnoclostridium pacaense, Ruminococcus bromii, Bacteroides faecis, Bifidobacterium pseudocatenulatum, Dialister succinatiphilus, Lachnospiraceae sp. FBI00033, Ruminococcus bromii, Bacteroides finegoldii, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Lachnospiraceae sp. FBI00071, Ruminococcus faecis, Bacteroides fragilis, Bilophila wadsworthia, Dorea formicigenerans, Lachnospiraceae sp. FBI00290, Ruminococcus faecis, Bacteroides kribbi / Bacteroides koreensis species cluster, Bilophila wadsworthia, Dorea formicigenerans, Lactobacillus rogosae, Ruthenibacterium lactatif ormans, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia faecis, Dorea longicatena, Lactobacillus rogosae, Senegalimassilia anaerobia, Bacteroides massiliensis, Blautia faecis, Dorea longicatena, Longicatena caecimuris, Sutterella massiliensis, Bacteroides nordii, Blautia hydrogenotrophica, Eggerthella lenta, Megasphaera massiliensis, Sutterella wadsworthensis, Bacteroides ovatus, Blautia massiliensis, Eggerthella lenta, Methanobrevibacter smithii, Sutterella wadsworthensis, Bacteroides salyersiae, Blautia obeum, Eggerthella lenta, Methanobrevibacter smithii,Turicibacter sanguinis, Bacteroides stercorirosoris, Blautia obeum, Eggerthella lenta, Monoglobus pectinilyticus, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, Monoglobus pectinilyticus, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, and Neglecta timonensis.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia X.” In certain embodiments, the Consortia X comprises Acidaminococcus intestini, Bacteroides thetaiotaomicron, Butyricimonas faecihominis, Eubacterium eligens, Monoglobus pectinilyticus, Akkermansia muciniphila, Bacteroides thetaiotaomicron, Catabacter hongkongensis, Eubacterium eligens, Neglecta timonensis, Alistipes onderdonkii, Bacteroides uniformis, Clostridiaceae sp. FBI00191, Eubacterium hallii, Neglecta timonensis, Alistipes onderdonkii, Bacteroides uniformis, Clostridiales sp. FBI00377, Eubacterium rectale, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium aldenense, Eubacterium rectale, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium aldenense, Eubacterium siraeum, Oxalobacter formigenes, Alistipes senegalensis, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium ventriosum, Parabacteroides distasonis, Alistipes shahii, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium xylanophilum, Parabacteroides distasonis, Alistipes shahii, Bacteroides xylanisolvens, Clostridium citroniae, Faecalibacterium prausnitzii, Parabacteroides merdae, Alistipes sp. FBI00180, Barnesiella intestinihominis, Clostridium citroniae, Faecalibacterium prausnitzii, Parabacteroides merdae, Alistipes sp. FBI00238, Bifidobacterium adolescentis, Clostridium clostridioforme, Fusicatenibacter saccharivorans, Paraprevotella clara, Alistipes timonensis, Bifidobacterium adolescentis, Clostridium fessum, Fusicatenibacter saccharivorans, Parasutterella excrementihominis, Anaerofustis stercorihominis, Bifidobacterium adolescentis, Clostridium scindens, Gordonibacter pamelaeae, Parasutterella excrementihominis, Anaerostipes hadrus, Bifidobacterium bifidum, Collinsella aerofaciens, Gordonibacter pamelaeae, Phascolarctobacterium faecium, Anaerostipes hadrus, Bifidobacterium catenulatum, Collinsella aerofaciens, Holdemanella biformis, Porphyromonas asaccharolytica, Anaerotruncus massiliensis, Bifidobacterium dentium, Coprococcus comes, Holdemanella biformis, Porphyromonas asaccharolytica, Bacteroides caccae, Bifidobacterium longum, Coprococcus comes, Hungatella effluvii, Roseburia hominis, Bacteroides caccae, Bifidobacterium longum, Coprococcus eutactus, Hungatella effluvii, Roseburia hominis, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dialister invisus, Hungatella effluvii, Ruminococcaceae sp. FBI00082 FBI00097, Bacteroides faecis, Bifidobacterium pseudocatenulatum, Dialister succinatiphilus, Lachnoclostridium pacaense, Ruminococcaceae sp. FBI00233, Bacteroidesfinegoldii, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Lachnoclostridium pacaense, Ruminococcus bromii, Bacteroides fragilis, Bilophila wadsworthia, Dorea formicigenerans, Lachnospiraceae sp. FBI00033, Ruminococcus bromii, Bacteroides kribbi / Bacteroides koreensis species cluster, Bilophila wadsworthia, Dorea formicigenerans, Lachnospiraceae sp. FBI00071, Ruminococcus faecis, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia faecis, Dorea longicatena, Lachnospiraceae sp. FBI00290, Ruminococcus faecis, Bacteroides massiliensis, Blautia faecis, Dorea longicatena, Lactobacillus rogosae, Ruthenibacterium lactatif ormans, Bacteroides nordii, Blautia hydrogenotrophica, Eggerthella lenta, Lactobacillus rogosae, Senegalimassilia anaerobia, Bacteroides ovatus, Blautia massiliensis, Eggerthella lenta, Longicatena caecimuris, Sutterella massiliensis, Bacteroides salyersiae, Blautia obeum, Eggerthella lenta, Megasphaera massiliensis, Sutterella wadsworthensis, Bacteroides stercorirosoris, Blautia obeum, Eggerthella lenta, Methanobrevibacter smithii, Sutterella wadsworthensis, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, Methanobrevibacter smithii, Turicibacter sanguinis, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, and Monoglobus pectinilyticus.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia XI.” In certain embodiments, the Consortia XI comprises Acidaminococcus intestini, Bifidobacterium longum, Fusicatenibacter saccharivorans, Bacteroides xylanisolvens, Clostridium bolteae, Akkermansia muciniphila, Bilophila wadsworthia, Gordonibacter pamelaeae, Turicibacter sanguinis, Collinsella aerofaciens, Alistipes onderdonkii, Blautia hydrogenotrophica, Hungatella effluvii, Bifidobacterium adolescentis, Coprococcus comes, Alistipes putredinis, Blautia massiliensis, Lachnoclostridium pacaense, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Alistipes senegalensis, Blautia obeum, Lachnospiraceae sp. FBI00033, Blautia faecis, Dorea longicatena, Alistipes shahii, Blautia wexlerae, Lachnospiraceae sp. FBI00071, Clostridium citroniae, Eggerthella lenta, Alistipes sp. FBI00180, Butyricimonas faecihominis, Lachnospiraceae sp. FBI00290, Faecalibacterium prausnitzii, Eggerthella lenta, Alistipes sp. FBI00238, Catabacter hongkongensis, Lactobacillus rogosae, Holdemanella biformis, Eggerthella lenta, Alistipes timonensis, Clostridiaceae sp. FBI00191, Longicatena caecimuris, Bacteroides xylanisolvens, Eisenbergiella tayi, Anaerofustis stercorihominis, Clostridiales sp. FBI00377, Megasphaera massiliensis, Bifidobacterium adolescentis, Eubacterium eligens, Anaerostipes hadrus, Clostridium aldenense, Methanobrevibacter smithii, Bifidobacterium pseudocatenulatum, Eubacterium rectale, Anaerotruncus massiliensis, Clostridium bolteae, Monoglobus pectinilyticus, Blautia faecis, Fusicatenibacter saccharivorans, Bacteroides caccae, Clostridium clostridioforme, Neglecta timonensis, Alistipes onderdonkii, Gordonibacterpamelaeae, Bacteroides coprocola, Clostridium fessum, Oxalobacter formigenes, Clostridium citroniae, Hungatella effluvia, Bacteroides faecis, Clostridium scindens, Oxalobacter formigenes, Alistipes putredinis, Hungatella effluvia, Bacteroides fmegoldii, Collinsella aerofaciens, Oxalobacter formigenes, Alistipes shahii, Lachnoclostridium pacaense, Bacteroides fragilis, Coprococcus comes, Parabacteroides distasonis, Anaerostipes hadrus, Lactobacillus rogosae, Bacteroides kribbi / Bacteroides koreensis species cluster, Coprococcus eutactus, Parabacteroides merdae, Bacteroides caccae, Methanobrevibacter smithii, Bacteroides massiliensis, Dialister invisus, Paraprevotella clara, Bacteroides kribbi / Bacteroides koreensis species cluster, Monoglobus pectinilyticus, Bacteroides nordii, Dialister succinatiphilus, Parasutterella excrementihominis, Bacteroides stercoris, Neglecta timonensis, Bacteroides ovatus, Dielma fastidiosa, Phascolarctobacterium faecium, Bacteroides thetaiotaomicron, Parabacteroides distasonis, Bacteroides salyersiae, Dorea formicigenerans, Porphyromonas asaccharolytica, Bacteroides uniformis, Parabacteroides merdae, Bacteroides stercorirosoris, Dorea longicatena, Roseburia hominis, Bacteroides vulgatus, Parasutterella excrementihominis, Bacteroides stercoris, Eggerthella lenta, Ruminococcaceae sp. FBI00082 FBI00097, Bacteroides xylanisolvens, Porphyromonas asaccharolytica, Bacteroides thetaiotaomicron, Eisenbergiella tayi, Ruminococcaceae sp. FBI00233, Bifidobacterium adolescentis, Roseburia hominis, Bacteroides uniformis, Eubacterium eligens, Ruminococcus bromii, Bifidobacterium longum, Ruminococcus bromii, Bacteroides vulgatus, Eubacterium hallii, Ruminococcus faecis, Bifidobacterium pseudocatenulatum, Ruminococcus faecis, Barnesiella intestinihominis, Eubacterium rectale, Ruthenibacterium lactatiformans, Bilophila wadsworthia, Sutterella wadsworthensis, Bifidobacterium bifidum, Eubacterium siraeum, Senegalimassilia anaerobia, Blautia obeum, Bifidobacterium catenulatum, Eubacterium ventriosum, Sutterella massiliensis, Blautia wexlerae, Bifidobacterium dentium, Eubacterium xylanophilum, Sutterella wadsworthensis, and Clostridium aldenense.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia XII.” In certain embodiments, the Consortia XII comprises Acidaminococcus intestini, Bacteroides uniformis, Clostridium bolteae, Faecalibacterium prausnitzii, Parasutterella excrementihominis, Akkermansia muciniphila, Bacteroides vulgatus, Clostridium bolteae, Faecalibacterium prausnitzii, Phascolarctobacterium faecium, Alistipes onderdonkii, Bacteroides vulgatus, Clostridium citroniae, Fusicatenibacter saccharivorans, Phascolarctobacterium faecium, Alistipes onderdonkii, Bacteroides xylanisolvens, Clostridium citroniae, Fusicatenibacter saccharivorans, Porphyromonas asaccharolytica, Alistipes putredinis, Bacteroides xylanisolvens, Clostridium clostridioforme, Gordonibacter pamelaeae, Porphyromonas asaccharolytica,Alistipes putredinis, Bacteroides xylanisolvens, Clostridium fessum, Gordonibacter pamelaeae, Roseburia hominis, Alistipes senegalensis, Barnesiella intestinihominis, Clostridium fessum, Holdemanella biformis, Roseburia hominis, Alistipes shahii, Bifidobacterium adolescentis, Clostridium scindens, Holdemanella biformis, Ruminococcaceae sp. FBI00082 FBI00097, Alistipes shahii, Bifidobacterium adolescentis, Collinsella aerofaciens, Hungatella effluvii, Ruminococcaceae sp. FBI00082 FBI00097, Alistipes sp. FBI00180, Bifidobacterium adolescentis, Collinsella aerofaciens, Hungatella effluvii, Ruminococcaceae sp. FBI00233, Alistipes sp. FBI00238, Bifidobacterium bifidum, Coprococcus comes, Hungatella effluvii, Ruminococcus bromii, Alistipes timonensis, Bifidobacterium bifidum, Coprococcus comes, Lachnoclostridium pacaense, Ruminococcus bromii, Anaerofustis stercorihominis, Bifidobacterium catenulatum, Coprococcus eutactus, Lachnoclostridium pacaense, Ruminococcus faecis, Anaerostipes hadrus, Bifidobacterium dentium, Coprococcus eutactus, Lachnospiraceae sp. FBI00033, Ruminococcus faecis, Anaerostipes hadrus, Bifidobacterium longum, Dialister invisus, Lachnospiraceae sp. FBI00071, Ruthenibacterium lactatif ormans, Anaerotruncus massiliensis, Bifidobacterium longum, Dialister succinatiphilus, Lachnospiraceae sp. FBI00290, Senegalimassilia anaerobia, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Lactobacillus rogosae, Sutterella massiliensis, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Lactobacillus rogosae, Sutter ell a wadsw orthensis, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Longicatena caecimuris, Sutterella wadsw orthensis, Bacteroides faecis, Bilophila wadsworthia, Dorea longicatena, Megasphaera massiliensis, Turicibacter sanguinis, Bacteroides finegoldii, Bilophila wadsworthia, Dorea longicatena, Methanobrevibacter smithii, Bacteroides thetaiotaomicron, Bacteroides fragilis, Blautia faecis, Eggerthella lenta, Methanobrevibacter smithii, Bacteroides uniformis, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia faecis, Eggerthella lenta, Monoglobus pectinilyticus, Clostridium aldenense, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia hydrogenotrophica, Eggerthella lenta, Monoglobus pectinilyticus, Clostridium aldenense, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia massiliensis, Eggerthella lenta, Neglecta timonensis, Eubacterium ventriosum, Bacteroides massiliensis, Blautia obeum, Eisenbergiella tccyi, Neglecta timonensis, Eubacterium xylanophilum, Bacteroides nordii, Blautia obeum, Eisenbergiella tayi, Oxalobacter formigenes, Paraprevotella clara, Bacteroides ovatus, Blautia wexlerae, Eubacterium eligens, Oxalobacter formigenes, Parasutterella excrementihominis, Bacteroides salyersiae, Blautia wexlerae, Eubacterium eligens, Oxalobacter formigenes, Bacteroides thetaiotaomicron, Bacteroides stercorirosoris, Butyricimonas faecihominis, Eubacterium hallii, Parabacteroides distasonis, Clostridiales sp. FBI00377,Bacteroides stercoris, Catabacter hongkongensis, Eubacterium rectale, Parabacteroides distasonis, Eubacterium siraeum, Bacteroides stercoris, Clostridiaceae sp. FBI00191, Eubacterium rectale, Parabacteroides merdae, and Parabacteroides merdae.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia XIII.” In certain embodiments, the Consortia XIII comprises Acidaminococcus intestini, Bacteroides thetaiotaomicron, Butyricimonas faecihominis, Eubacterium eligens, Monoglobus pectinilyticus, Akkermansia muciniphila, Bacteroides thetaiotaomicron, Catabacter hongkongensis, Eubacterium eligens, Neglecta timonensis, Alistipes onderdonkii, Bacteroides uniformis, Clostridiaceae sp. FBI00191, Eubacterium hallii, Neglecta timonensis, Alistipes onderdonkii, Bacteroides uniformis, Clostridiales sp. FBI00377, Eubacterium rectale, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium aldenense, Eubacterium rectale, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium aldenense, Eubacterium siraeum, Oxalobacter formigenes, Alistipes senegalensis, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium ventriosum, Parabacteroides distasonis, Alistipes shahii, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium xylanophilum, Parabacteroides distasonis, Alistipes shahii, Bacteroides xylanisolvens, Clostridium citroniae, Faecalibacterium prausnitzii, Parabacteroides merdae, Alistipes sp. FBI00180, Barnesiella intestinihominis, Clostridium citroniae, Faecalibacterium prausnitzii, Parabacteroides merdae, Alistipes sp. FBI00238, Bifidobacterium adolescentis, Clostridium clostridioforme, Fusicatenibacter saccharivorans, Paraprevotella clara, Alistipes timonensis, Bifidobacterium adolescentis, Clostridium fessum, Fusicatenibacter saccharivorans, Parasutterella excrementihominis, Anaerofustis stercorihominis, Bifidobacterium adolescentis, Clostridium scindens, Gordonibacter pamelaeae, Parasutterella excrementihominis, Anaerostipes hadrus, Bifidobacterium bifidum, Collinsella aerofaciens, Gordonibacter pamelaeae, Phascolarctobacterium faecium, Anaerostipes hadrus, Bifidobacterium catenulatum, Collinsella aerofaciens, Holdemanella biformis, Porphyromonas asaccharolytica, Anaerotruncus massiliensis, Bifidobacterium dentium, Coprococcus comes, Holdemanella biformis, Porphyromonas asaccharolytica, Bacteroides caccae, Bifidobacterium longum, Coprococcus comes, Hungatella effluvii, Roseburia hominis, Bacteroides caccae, Bifidobacterium longum, Coprococcus eutactus, Hungatella effluvii, Roseburia hominis, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dialister invisus, Hungatella effluvii, Ruminococcaceae sp. FBI00082 FBI00097, Bacteroides faecis, Bifidobacterium pseudocatenulatum, Dialister succinatiphilus, Lachnoclostridium pacaense, Ruminococcaceae sp. FBI00233, Bacteroides finegoldii, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Lachnoclostridium pacaense,Ruminococcus bromii, Bacteroides fragilis, Bilophila wadsworthia, Dorea formicigenerans, Lachnospiraceae sp. FBI00033, Ruminococcus bromii, Bacteroides kribbi / Bacteroides koreensis species cluster, Bilophila wadsworthia, Dorea formicigenerans, Lachnospiraceae sp. FBI00071, Ruminococcus faecis, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia faecis, Dorea longicatena, Lachnospiraceae sp. FBI00290, Ruminococcus faecis, Bacteroides massiliensis, Blautia faecis, Dorea longicatena, Lactobacillus rogosae, Ruthenibacterium I actatif ormans, Bacteroides nordii, Blautia hydrogenotrophica, Eggerthella lenta, Lactobacillus rogosae, Senegalimassilia anaerobia, Bacteroides ovatus, Blautia massiliensis, Eggerthella lenta, Longicatena caecimuris, Sutterella massiliensis, Bacteroides salyersiae, Blautia obeum, Eggerthella lenta, Megasphaera massiliensis, Sutterella wadsworthensis, Bacteroides stercorirosoris, Blautia obeum, Eggerthella lenta, Methanobrevibacter smithii, Sutterella wadsworthensis, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, Methanobrevibacter smithii, Turicibacter sanguinis, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, and Monoglobus pectinilyticus.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia XIV.” In certain embodiments, the Consortia XIV comprises Acidaminococcus intestini, Bacteroides uniformis, Clostridium citroniae, Eubacterium siraeum, Parasutterella excrementihominis, Akkermansia muciniphila, Bacteroides uniformis, Clostridium citroniae, Eubacterium ruminantium, Parasutterella excrementihominis, Alistipes finegoldii, Bacteroides vulgatus, Clostridium clostridioforme, Eubacterium ventriosum, Phascolarctobacterium faecium, Alistipes onderdonkii, Bacteroides vulgatus, Clostridium scindens, Eubacterium xylanophilum, Phascolarctobacterium faecium, Alistipes onderdonkii, Bacteroides xylanisolvens, Clostridium swellfunianum, Faecalibacterium prausnitzii, Phocea massiliensis, Alistipes putredinis, Bacteroides xylanisolvens, Clostridium symbiosum, Faecalibacterium prausnitzii, Phocea massiliensis, Alistipes putredinis, Barnesiella intestinihominis, Clostridium symbiosum, Fusicatenibacter saccharivorans, Porphyromonas asaccharolytica, Alistipes senegalensis, Bifidobacterium adolescentis, Collinsella aerofaciens, Fusicatenibacter saccharivorans, Porphyromonas asaccharolytica, Alistipes senegalensis, Bifidobacterium adolescentis, Collinsella aerofaciens, Gordonibacter pamelaeae, Roseburia hominis, Alistipes shahii, Bifidobacterium bifidum, Coprococcus comes, Gordonibacter pamelaeae, Roseburia hominis, Alistipes shahii, Bifidobacterium bifidum, Coprococcus comes, Holdemanella biformis, Ruminococcus bromii, Alistipes timonensis, Bifidobacterium catenulatum, Coprococcus eutactus, Holdemanella biformis, Ruminococcus bromii, Anaerofustis stercorihominis, Bifidobacterium dentium, Coprococcus eutactus, Hungatella effluvii, Ruminococcus faecis, Anaerostipes hadrus,Bifidobacterium faecale, Desulfovibrio desulfuricans, Hungatella hathewayi, Ruminococcus faecis. Anaerostipes hadrus, Bifidobacterium longum, Desulfovibrio desulfuricans, Hungatella hathewayi, Ruthenibacterium lactatif ormans, Anaerotruncus colihominis, Bifidobacterium longum, Dialister invisus, Hydrogenoanaerobacterium saccharovorans, Senegalimassilia anaerobia, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dialister succinatiphilus, Lachnoclostridium pacaense, Sutterella massiliensis, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Lachnoclostridium pacaense, Sutterella wadsworthensis, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Lachnospira pectinoschiza, Sutterella wadsworthensis, Bacteroides faecis, Blautia faecis, Dorea formicigenerans, Lachnospira pectinoschiza, Turicibacter sanguinis, Bacteroides finegoldii, Blautia faecis, Dorea longicatena, Longicatena caecimuris, Bacteroides stercoris, Bacteroides fragilis, Blautia hydrogenotrophica, Dorea longicatena, Megasphaera massiliensis, Bacteroides stercoris, Bacteroides koreensis, Blautia luti, Eggerthella lenta, Methanobrevibacter smithii, Bacteroides thetaiotaomicron, Bacteroides koreensis, Blautia obeum, Eggerthella lenta, Methanobrevibacter smithii, Bacteroides thetaiotaomicron, Bacteroides kribbi, Blautia obeum, Eggerthella lenta, Monoglobus pectinilyticus, Clostridium aldenense, Bacteroides kribbi, Blautia wexlerae, Eggerthella lenta, Monoglobus pectinilyticus, Clostridium aldenense, Bacteroides massiliensis, Blautia wexlerae, Eisenbergiella tayi, Neglecta timonensis, Clostridium bolteae, Bacteroides nordii, Butyricimonas faecihominis, Eisenbergiella tayi, Oxalobacter formigenes, Clostridium bolteae, Bacteroides oleiciplenus, Catabacter hongkongensis, Emergencia timonensis, Oxalobacter formigenes, Par bacteroides merdae, Bacteroides ovatus, Citrobacter freundii, Eubacterium eligens, Oxalobacter formigenes, Parabacteroides merdae, Bacteroides salyer siae, Clostridiaceae sp., Eubacterium eligens, Parabacteroides distasonis, Paraprevotella clara, Eubacterium rectale, Eubacterium rectale, Eubacterium hallii, Parabacteroides distasonis, and Eubacterium oxidoreducens .In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia XV.” In certain embodiments, the Consortia XV comprises Acidaminococcus intestini, Bacteroides thetaiotaomicron, Butyricimonas faecihominis, Eubacterium eligens, Monoglobus pectinilyticus, Akkermansia muciniphila, Bacteroides thetaiotaomicron, Catabacter hongkongensis, Eubacterium eligens, Neglecta timonensis, Alistipes onderdonkii, Bacteroides uniformis, Clostridiaceae sp. FBI00191, Eubacterium hallii, Neglecta timonensis, Alistipes onderdonkii, Bacteroides uniformis, Clostridiales sp. FBI00377, Eubacterium rectale, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium aldenense, Eubacterium rectale, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridiumaldenense, Eubacterium siraeum, Oxalobacter formigenes, Alistipes senegalensis, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium ventriosum, Parabacteroides distasonis, Alistipes shahii, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium xylanophilum, Parabacteroides distasonis, Alistipes shahii, Bacteroides xylanisolvens, Clostridium citroniae, Faecalibacterium prausnitzii, Parabacteroides merdae, Alistipes sp. FBI00180, Barnesiella intestinihominis, Clostridium citroniae, Faecalibacterium prausnitzii, Parabacteroides merdae, Alistipes sp. FBI00238, Bifidobacterium adolescentis, Clostridium clostridioforme, Fusicatenibacter saccharivorans, Paraprevotella clara, Alistipes timonensis, Bifidobacterium adolescentis, Clostridium fessum, Fusicatenibacter saccharivorans, Parasutterella excrementihominis, Anaerofustis stercorihominis, Bifidobacterium adolescentis, Clostridium scindens, Gordonibacter pamelaeae, Parasutterella excrementihominis, Anaerostipes hadrus, Bifidobacterium bifidum, Collinsella aerofaciens, Gordonibacter pamelaeae, Phascolarctobacterium faecium, Anaerostipes hadrus, Bifidobacterium catenulatum, Collinsella aerofaciens, Holdemanella biformis, Porphyromonas asaccharolytica, Anaerotruncus massiliensis, Bifidobacterium dentium, Coprococcus comes, Holdemanella biformis, Porphyromonas asaccharolytica, Bacteroides caccae, Bifidobacterium longum, Coprococcus comes, Hungatella effluvii, Roseburia hominis, Bacteroides caccae, Bifidobacterium longum, Coprococcus eutactus, Hungatella effluvii, Roseburia hominis, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dialister invisus, Hungatella effluvii, Ruminococcaceae sp. FBI00082 FBI00097, Bacteroides faecis, Bifidobacterium pseudocatenulatum, Dialister succinatiphilus, Lachnoclostridium pacaense, Ruminococcaceae sp. FBI00233, Bacteroides finegoldii, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Lachnoclostridium pacaense, Ruminococcus bromii, Bacteroides fragilis, Bilophila wadsworthia, Dorea formicigenerans, Lachnospiraceae sp. FBI00033, Ruminococcus bromii, Bacteroides kribbi / Bacteroides koreensis species cluster, Bilophila wadsworthia, Dorea formicigenerans, Lachnospiraceae sp. FBI00071, Ruminococcus faecis, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia faecis, Dorea longicatena, Lachnospiraceae sp. FBI00290, Ruminococcus faecis, Bacteroides massiliensis, Blautia faecis, Dorea longicatena, Lactobacillus rogosae, Ruthenibacterium lactatif ormans, Bacteroides nordii, Blautia hydrogenotrophica, Eggerthella lenta, Lactobacillus rogosae, Senegalimassilia anaerobia, Bacteroides ovatus, Blautia massiliensis, Eggerthella lenta, Longicatena caecimuris, Sutterella massiliensis, Bacteroides salyersiae, Blautia obeum, Eggerthella lenta, Megasphaera massiliensis, Sutterella wadsworthensis, Bacteroides stercorirosoris, Blautia obeum, Eggerthella lenta, Methanobrevibacter smithii, Sutterella wadsworthensis, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi,Methanobrevibacter smithii, Turicibacter sanguinis, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, and Monoglobus pectinilyticus.In certain embodiments, the Consortia comprises a plurality of microbes (e g., active microbes and supportive community microbes) designated as “Consortia XVI.” In certain embodiments, the Consortia XVI comprises Acidaminococcus intestini, Bacteroides uniformis, Clostridium citroniae, Eubacterium ventriosum, Parasutterella excrementihominis, Akkermansia muciniphila, Bacteroides uniformis, Clostridium clostridioforme, Eubacterium siraeum, Phascolarctobacterium faecium, Alistipes finegoldii, Bacteroides vulgatus, Clostridium scindens, Eubacterium xylanophilum, Phascolarctobacterium faecium, Alistipes onderdonkii, Bacteroides vulgatus, Clostridium swellfunianum, Faecalibacterium prausnitzii, Phocea massiliensis, Alistipes onderdonkii, Bacteroides xylanisolvens, Clostridium symbiosum, Faecalibacterium prausnitzii, Phocea massiliensis, Alistipes putredinis, Bacteroides xylanisolvens, Clostridium symbiosum, Fusicatenibacter saccharivorans, Porphyromonas asaccharolytica, Alistipes putredinis, Barnesiella intestinihominis, Collinsella aerofaciens, Fusicatenibacter saccharivorans, Porphyromonas asaccharolytica, Alistipes senegalensis, Bifidobacterium adolescentis, Collinsella aerofaciens, Gordonibacter pamelaeae, Roseburia hominis, Alistipes senegalensis, Bifidobacterium adolescentis, Coprococcus comes, Gordonibacter pamelaeae, Roseburia hominis, Alistipes shahii, Bifidobacterium bifidum, Coprococcus comes, Holdemanella biformis, Ruminococcus bromii, Alistipes shahii, Bifidobacterium bifidum, Coprococcus eutactus, Holdemanella biformis, Ruminococcus bromii, Alistipes timonensis, Bifidobacterium catenulatum, Coprococcus eutactus, Hungatella effluvii, Ruminococcus faecis, Anaerofustis stercorihominis, Bifidobacterium dentium, Desulfovibrio desulfuricans, Hungatella hathewayi, Ruminococcus faecis, Anaerostipes hadrus, Bifidobacterium faecale, Desulfovibrio desulfuricans, Hungatella hathewayi, Ruthenibacterium lactatiformans, Anaerostipes hadrus, Bifidobacterium longum, Dialister invisus, Hydrogenoanaerobacterium saccharovorans, Senegalimassilia anaerobia, Anaerotruncus colihominis, Bifidobacterium longum, Dialister succinatiphilus, Lachnoclostridium pacaense, Sutterella massiliensis, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Lachnoclostridium pacaense, Sutterella wadsworthensis, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Lachnospira pectinoschiza, Sutterella wadsworthensis, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Lachnospira pectinoschiza, Turicibacter sanguinis, Bacteroides faecis, Blautia faecis, Dorea longicatena, Longicatena caecimuris, Bacteroides stercoris, Bacteroides finegoldii, Blautia faecis, Dorea longicatena, Megasphaera massiliensis, Bacteroides stercoris, Bacteroides fragilis, Blautia hydrogenotrophica, Eggerthella lenta, Methanobrevibacter smithii, Bacteroides thetaiotaomicron, Bacteroides koreensis, Blautia luti,Eggerthella lenta, Methanobrevibacter smithii, Bacteroides thetaiotaomicron, Bacteroides koreensis, Blautia obeurn, Eggerthella lenta, Monoglobus pectinilyticus, Clostridium aldenense, Bacteroides kribbi, Blautia obeum, Eggerthella lenta, Monoglobus pectinilyticus, Clostridium bolteae, Bacteroides kribbi, Blautia wexlerae, Eisenbergiella tayi, Neglecta timonensis, Clostridium bolteae, Bacteroides massiliensis, Blautia wexlerae, Eisenbergiella tayi, Oxalobacter formigenes, Clostridium citroniae, Bacteroides nordii, Butyricimonas faecihominis, Emergencia timonensis, Oxalobacter formigenes, Eubacterium oxidoreducens, Bacteroides oleiciplenus, Catabacter hongkongensis, Eubacterium eligens, Oxalobacter formigenes, Eubacterium rectale, Bacteroides ovatus, Clostridiaceae sp., Eubacterium eligens, Parabacteroides distasonis, Eubacterium rectale, Bacteroides salyersiae, Clostridium aldenense, Eubacterium hallii, Parabacteroides distasonis, Eubacterium ruminantium, Parasutterella excrementihominis, Paraprevotella clara, Parabacteroides merdae, and Parabacteroides merdae.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia XVII.” In certain embodiments, the Consortia XVII comprises Acidaminococcus intestini, Bacteroides uniformis, Clostridium bolteae, Faecalicatena contorta, Roseburia hominis, Acutalibacter timonensis, Bacteroides vulgatus, Clostridium citroniae, Fusicatenibacter saccharivorans, Roseburia hominis, Akkermansia muciniphila, Bacteroides vulgatus, Clostridium citroniae, Fusicatenibacter saccharivorans, Ruminococcaceae sp. FBI00097, Alistipes onderdonkii, Bacteroides xylanisolvens, Clostridium clostridioforme, Gordonibacter pamelaeae, Ruminococcaceae sp. FBI0009, Alistipes onderdonkii, Bacteroides xylanisolvens, Clostridium fessum, Gordonibacter pamelaeae, Ruminococcaceae sp. FBI00233, Alistipes putredinis, Bacteroides xylanisolvens, Clostridium fessum, Holdemanella biformis, Ruminococcus bromii, Alistipes putredinis, Barnesiella intestinihominis, Clostridium scindens, Holdemanella biformis, Ruminococcus bromii, Alistipes senegalensis, Bifidobacterium adolescentis, Collinsella aerofaciens, Hungatella effiuvii, Ruminococcus faecis, Alistipes shahii, Bifidobacterium adolescentis, Collinsella aerofaciens, Hungatella effiuvii, Ruminococcus faecis, Alistipes sp. FBI00180, Bifidobacterium adolescentis, Coprococcus comes, Hungatella effiuvii, Ruthenibacterium lactatiformans, Alistipes sp. FBI00238, Bifidobacterium bifidum, Coprococcus comes, Lachnoclostridium pacaense, Senegalimassilia anaerobia, Alistipes timonensis, Bifidobacterium bifidum, Coprococcus eutactus, Lachnoclostridium pacaense, Sutterella massiliensis, Anaerofustis stercorihominis, Bifidobacterium catenulatum, Coprococcus eutactus, Lachnospiraceae sp. FBI00033, Sutterella wadsworthensis, Anaerostipes hadrus, Bifidobacterium dentium, Dialister invisus, Lachnospiraceae sp. FBI00071, Sutterella wadsworthensis, Anaerostipes hadrus, Bifidobacterium longum, Dialister succinatiphilus, Lachnospiraceae sp. FBI00290, Turicibactersanguinis, Anaerotruncus massiliensis, Bifidobacterium longum, Dielma fastidiosa, Lactobacillus rogosae, Bacteroides stercoris, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Lactobacillus rogosae, Bacteroides stercoris, Bacteroides caccae, Bifidobacterium pseudocatenulatum, Dorea formicigenerans, Lactonifactor longoviformis, Bacteroides thetaiotaomicron, Bacteroides coprocola, Bilophila wadsworthia, Dorea longicatena, Longicatena caecimuris, Bacteroides thetaiotaomicron, Bacteroides faecis, Bilophila wadsworthia, Dorea longicatena, Megasphaera massiliensis, Bacteroides uniformis, Bacteroides finegoldii, Blautia faecis, Eggerthella lenta, Monoglobus pectinilyticus, Citrobacter portucalensis, Bacteroides fragilis, Blautia faecis, Eggerthella lenta, Monoglobus pectinilyticus, Clostridiaceae sp. FBI00191, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia hydrogenotrophica, Eisenbergiella tayi, Oxalobacter formigenes, Clostridium aldenense, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia massiliensis, Eisenbergiella tayi, Oxalobacter formigenes, Clostridium aldenense, Bacteroides kribbi / Bacteroides koreensis species cluster, Blautia obeum, Emergencia timonensis, Oxalobacter formigenes, Clostridium bolteae, Bacteroides massiliensis, Blautia obeum, Eubacterium eligens, Parabacteroides distasonis, Eubacterium siraeum, Bacteroides nordii, Blautia wexlerae, Eubacterium eligens, Parabacteroides merdae, Eubacterium ventriosum, Bacteroides ovatus, Blautia wexlerae, Eubacterium hallii, Parabacteroides merdae, Eubacterium xylanophilum, Bacteroides salyersiae, Butyricimonas faecihominis, Eubacterium rectale, Paraprevotella clara, Faecalibacterium prausnitzii, Bacteroides stercorirosoris, Catabacter hongkongensis, Eubacterium rectale, Parasutterella excrementihominis, Faecalibacterium prausnitzii, Phascolarctobacterium faecium, Phascolarctobacterium faecium, Porphyromonas asaccharolytica, Parasutterella excrementihominis, and Porphyromonas asaccharolytica.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia XVIII.” In certain embodiments, the Consortia XVIII comprises Bacteroides caccae, Bifidobacterium longum, Clostridium scindens, Eggerthella lenta, Parabacteroides merdae, Bacteroides salyersiae, Bifidobacterium pseudocatenulatum, Clostridium symbiosum, Eggerthella lenta, Ruminococcus bromii, Bacteroides thetaiotaomicron, Bifidobacterium pseudocatenulatum, Collinsella aerofaciens, Faecalibacterium prausnitzii, Ruminococcus bromii, Bacteroides thetaiotaomicron, Bifidobacterium pseudocatenulatum, Desulfovibrio desulfuricans, Neglecta timonensis, Bacteroides vulgatus, Clostridium amygdalinum, Dorea longicatena, Oxalobacter formigenes, Bifidobacterium dentium, Clostridium citroniae, Eggerthella lenta, Oxalobacter formigenes, Bifidobacterium longum, Clostridium citroniae, Eggerthella lenta, and Oxalobacter formigenes.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia XIX.” In certain embodiments, the Consortia XIX comprises Acidaminococcus intestini, Bacteroides stercoris, Blautia wexlerae, Eisenbergiella tayi, Monoglobus pectinilyticus, Acutalibacter timonensis, Bacteroides stercoris, Blautia wexlerae , Eisenbergiella tayi, Monoglobus pectinilyticus, Akkermansia muciniphila, Bacteroides thetaiotaomicron, Butyricimonas faecihominis, Emergencia timonensis, Parabacteroides distasonis, Alistipes onderdonkii, Bacteroides thetaiotaomicron, Catabacter hongkongensis, Eubacterium eligens, Oxalobacter formigenes, Alistipes onderdonkii, Bacteroides uniformis, Clostridiaceae sp. FBI00191, Eubacterium eligens, Oxalobacter formigenes, Alistipes putredinis, Bacteroides uniformis, Clostridium aldenense, Eubacterium hallii, Oxalobacter formigenes, Alistipes putredinis, Bacteroides vulgatus, Clostridium aldenense, Eubacterium rectale, Parabacteroides distasonis, Alistipes senegalensis, Bacteroides vulgatus, Clostridium bolteae, Eubacterium rectale, Parabacteroides merdae, Alistipes shahii, Bacteroides xylanisolvens, Clostridium bolteae, Eubacterium siraeum, Parabacteroides merdae, Alistipes shahii, Bacteroides xylanisolvens, Clostridium citroniae, Eubacterium ventriosum, Paraprevotella clara, Alistipes sp. FBI00180, Bacteroides xylanisolvens, Clostridium citroniae, Eubacterium xylanophilum, Parasutterella excrementihominis, Alistipes sp. FBI00238, Barnesiella intestinihominis, Clostridium clostridioforme, Faecalibacterium prausnitzii, Parasutterella excrementihominis, Alistipes timonensis, Bifidobacterium adolescentis, Clostridium fessum, Fusicatenibacter saccharivorans, Phascolarctobacterium faecium, Anaerofustis stercorihominis, Bifidobacterium adolescentis, Clostridium scindens, Fusicatenibacter saccharivorans, Porphyromonas asaccharolytica, Anaerostipes hadrus, Bifidobacterium bifidum, Collinsella aerofaciens, Gordonibacter pamelaeae, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium catenulatum, Collinsella aerofaciens, Gordonibacter pamelaeae, Roseburia hominis, Anaerotruncus massiliensis, Bifidobacterium dentium, Coprococcus comes, Holdemanella biformis, Ruminococcaceae sp. FBI00097, Bacteroides caccae, Bifidobacterium longum, Coprococcus comes, Hungatella effiuvii, Ruminococcaceae sp. FBI00233, Bacteroides caccae, Bifidobacterium longum, Coprococcus eutactus, Hungatella effiuvii, Ruminococcus bromii, Bacteroides coprocola, Bifidobacterium pseudocatenulatum, Dialister invisus, Hungatella hathewayi, Ruminococcus bromii, Bacteroides faecis, Bifidobacterium pseudocatenulatum, Dialister succinatiphilus, Lachnoclostridium pacaense, Ruminococcus faecis, Bacteroides finegoldii, Bifidobacterium pseudocatenulatum, Dielma fastidiosa, Lachnoclostridium pacaense, Ruminococcus faecis, Bacteroides fragilis, Bifidobacterium adolescentis , Dorea formicigenerans, Lachnospiraceae sp. FBI00033, Ruthenibacterium lactatiformans, Bacteroides kribbi, Bilophila wadsworthia, Doreaformicigenerans, Lachnospiraceae sp. FBI00071, Senegalimassilia anaerobia, Bacteroides kribbi, Bilophila wadsworthia, Dorea longicatena, Lachnospiraceae sp. FBI00290, Sutterella massiliensis, Bacteroides massiliensis, Blautia faecis, Dorea longicatena, Lactobacillus rogosae, Sutterella wadsw orthensis, Bacteroides nordii, Blautia hydrogenotrophica, Eggerthella lenta, Lactobacillus rogosae , Sutterella wadsw orthensis, Bacteroides ovatus, Blautia massiliensis, Eggerthella lenta, Longicatena caecimuris, Turicibacter sanguinis, Bacteroides salyersiae, Blautia obeum, Eggerthella lenta, Megasphaera massiliensis, Bacteroides stercorirosoris, Blautia obeum, Eggerthella lenta, and Methanobrevibacter smithii.In certain embodiments, the Consortia comprises the microbiota comprised in Consortia I. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia II. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia III. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia IV. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia V. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia VI. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia VII. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia VIII. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia IX. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia X. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia XI. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia XII. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia XIII. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia XIV. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia XV. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia XVI. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia XVII. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia XVIII. In certain embodiments, the Consortia comprises the microbiota comprised in Consortia XIX.In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia I. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia II. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia III. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia IV. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia V. In certain embodiments, the Consortia comprises themicrobiota that are at least 97% or at least 98% identical to those listed in Consortia VI. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia VII. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia VIII. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia IX. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia X. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia XI. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia XII. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia XIII. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia XIV. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia XV. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia XVI. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia XVII. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia XVIII. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Consortia XIX.In certain embodiments, the Consortia comprises at least 146 microbes, at least 147 microbes, or at least 148 microbes of Consortia I. In certain embodiments, the Consortia comprises at least 72 microbes, at least 73 microbes, or at least 74 microbes of Consortia II. In certain embodiments, the Consortia comprises at least 85 microbes, at least 86 microbes, or at least 87 microbes of Consortia III. In certain embodiments, the Consortia comprises at least 84 microbes, at least 85 microbes, or at least 86 microbes of Consortia IV. In certain embodiments, the Consortia comprises at least 153 microbes, at least 154 microbes, or at least 155 microbes of Consortia V. In certain embodiments, the Consortia comprises at least 176 microbes, at least 177 microbes, or at least 178 microbes of Consortia VI. In certain embodiments, the Consortia comprises at least 153 microbes, at least 154 microbes, or at least 155 microbes of Consortia VII. In certain embodiments, the Consortia comprises at least 153 microbes, at least 154 microbes, or at least 155 microbes of Consortia VIII. In certain embodiments, the Consortia comprises at least 148 microbes, at least 149 microbes, or at least 150 microbes of Consortia IX. In certain embodiments, the Consortia comprises at least 149 microbes, at least 150 microbes, or at least 151microbes of Consortia X. In certain embodiments, the Consortia comprises at least 147 microbes, at least 148 microbes, or at least 149 microbes of Consortia XI. In certain embodiments, the Consortia comprises at least 155 microbes, at least 156 microbes, or at least 157 microbes of Consortia XII. In certain embodiments, the Consortia comprises at least 149 microbes, at least 150 microbes, or at least 151 microbes of Consortia XIII. In certain embodiments, the Consortia comprises at least 155 microbes, at least 156 microbes, or at least 157 microbes of Consortia XIV. In certain embodiments, the Consortia comprises at least 149 microbes, at least 150 microbes, or at least 151 microbes of Consortia XV. In certain embodiments, the Consortia comprises at least 153 microbes, at least 154 microbes, or at least 155 microbes of Consortia XVI. In certain embodiments, the Consortia comprises at least 150 microbes, at least 151 microbes, or at least 152 microbes of Consortia XVII. In certain embodiments, the Consortia comprises at least 29 microbes, or at least 30 microbes of Consortia XVIII. In certain embodiments, the Consortia comprises at least 143 microbes, at least 144 microbes, or at least 145 microbes of Consortia XIX.In certain embodiments, a microbial consortium described herein comprises a microbial strain having a relative abundance of approximately 90%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, 10%, 5%, 1%, 0.1%, 0.01%, 0.001%, 0.0001%, 0.00001%, or 0.000001% of the total microbial consortium. In certain embodiments, the relative abundance of a microbial strain is determined by metagenomic sequencing and calculated as the percentage of reads that are classified as an identified microbial strain, divided by the genome size. In certain embodiments, the relative abundance of a microbial strain of the present disclosure is determined by metagenomic shotgun sequencing.In certain embodiments, the Consortia comprises the microbiota set forth in Table 1. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in Table 1. In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “FB-001.” In certain embodiments, the Consortia comprises a plurality of microbes listed in Table 1. In certain embodiments, the Consortia comprises at least 143 microbes, at least 144 microbes, or at least 145 microbes of FB-001. Table 1 is provided below:Table 1. FB-001 Drug SubstancesIn certain embodiments, the Consortia is FB-003 as set forth in Table 2. In certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98%identical to those listed in Table 2. In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “FB-003.” In certain embodiments, the Consortia comprises a plurality of microbes listed in Table 2. In certain embodiments, the Consortia comprises at least 140 microbes, at least 141 microbes, or at least 142 microbes of FB-001. Table 2 is provided below:Table 2. FB-003 Drug SubstancesIn certain embodiments, the Consortia comprises the microbiota that are at least 97% or at least 98% identical to those listed in any of Consortia I-XIX or Tables 1 or 2.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia A.” In certain embodiments, Consortia A comprises one or more strains of each of the species Anaerofustis stercorihominis, Anaerostipes hadrus, Bacteroides kribbi, Bacteroides stercoris, Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides xylanisolvens, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Bifidobacterium dentinum, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Blautia obeum, Blautia wexlerae, Butyricimonas faecihominis, Clostridium bolteae, Clostridium citroniae, Clostridium scindens, Collinsella aerofaciens, Coprococcus comes, Dorea formicigenerans, Dorea longicatena, Eggerthella lenta, Emergencia timonensis, Eubacterium eligens, Eubacterium hallii, Eubacterium ventriosum, Hungatella hathewayi, Parabacteroides distasonis, Parabacteroides merdae, Roseburia hominis, Ruminococcus faecis, Alistipes onderdonkii, Alistipes senegalensis, Alistipes shahii, Alistipes timonensis, Anaerotruncus massiliensis, Bacteroides caccae, Bacteroides fragilis, Bacteroides ovatus, Bacteroides uniformis, Bifidobacterium bifidum, Bilophila wadsworthia, Catabacter hongkongensis, Clostridium aldenense, Coprococcus eutactus, Dielma fastidiosa, Eubacterium rectale, Eubacterium siraeum, Faecalibacterium prausnitzii, Gordonibacter pamelaeae, Methanobrevibacter smithii, Monoglobus pectinilyticus, Paraprevotella clara, Ruminococcus bromii, Ruthenibacterium lactatiformans, Sutterella wadsworthensis, Akkermansia muciniphila, Bacteroides massiliensis, Dialister succinatiphilus, Eubacterium xylanophilum, Acidaminococcus intestine, Bacteroides faecis, Blautia faecis, Blautia hydrogenotrophica, Blautia massiliensis, Eisenbergiella tayi, Fusicatenibacter saccharivorans, Megasphaera massiliensis, Parasutterellaexcrementihominis, Phascolarctobacterium faecium, Ruminococcaceae sp. FBI00097, Ruminococcaceae sp. FB 100233, Sutterella massiliensis, Alistipes putredinis, Holdemanella biformis, Bifidobacterium dentium, Bacteroides finegoldii, Bacteroides nordii, Bacteroides salyersiae, Bacteroides stercorirosoris, Clostridiaceae sp. FBI00191, Clostridium clostridioforme, Clostridium fessum, Hungatella effluvia, Lachnoclostridium pacaense, Lachnospiraceae sp. FBI00033, Lachnospiraceae sp. FBI00071, Lachnospiraceae sp. FBI00290, Lactobacillus rogosae, Longicatena caecimuris, Bamesiella intestinihominis, Porphyromonas asaccharolytica, Acutalibacter timonensis, Turicibacter sanguinis, Alistipes sp. FB 100238, Bacteroides coprocola, Dialister invisus.In certain embodiments, the Consortia comprises a plurality of microbes (e.g., active microbes and supportive community microbes) designated as “Consortia B.” In certain embodiments, Consortia B comprises one or more strains of each of the species Anaerofustis stercorihominis, Anaerostipes hadrus, Bacteroides kribbi, Bacteroides stercoris, Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides xylanisolvens, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Bifidobacterium dentinum, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Blautia obeum, Blautia wexlerae, Butyricimonas faecihominis, Clostridium bolteae, Clostridium citroniae, Clostridium scindens, Collinsella aerofaciens, Coprococcus comes, Dorea formicigenerans, Dorea longicatena, Eggerthella lenta, Emergencia timonensis, Eubacterium eligens, Eubacterium hallii, Eubacterium ventriosum, Hungatella hathewayi, Parabacteroides distasonis, Parabacteroides merdae, Roseburia hominis, Ruminococcus faecis, Alistipes onderdonkii, Alistipes senegalensis, Alistipes shahii, Alistipes timonensis, Anaerotruncus massiliensis, Bacteroides caccae, Bacteroides fragilis, Bacteroides ovatus, Bacteroides uniformis, Bifidobacterium bifidum, Bilophila wadsworthia, Catabacter hongkongensis, Clostridium aldenense, Coprococcus eutactus, Dielma fastidiosa, Eubacterium rectale, Eubacterium siraeum, Faecalibacterium prausnitzii, Gordonibacter pamelaeae, Methanobrevibacter smithii, Monoglobus pectinilyticus, Paraprevotella clara, Ruminococcus bromii, Ruthenibacterium lactatiformans, Sutterella wadsworthensis, Akkermansia muciniphila, Bacteroides massiliensis, Dialister succinatiphilus, Eubacterium xylanophilum, Acidaminococcus intestine, Bacteroides faecis, Blautia faecis, Blautia hydrogenotrophica, Blautia massiliensis, Eisenbergiella tayi, Fusicatenibacter saccharivorans, Megasphaera massiliensis, Parasutterella excrementihominis, Phascolarctobacterium faecium, Ruminococcaceae, Sutterella massiliensis, Alistipes putredinis, Holdemanella biformis, Bifidobacterium dentium, Bacteroides finegoldii, Bacteroides nordii, Bacteroides salyersiae, Bacteroides stercorirosoris, Clostridiaceae, Clostridium clostridioforme, Clostridium fessum, Hungatella effluvia, Lachnoclostridium pacaense, Lachnospiraceae, Lactobacillus rogosae, Longicatena caecimuris, Barnesiellaintestinihominis, Porphyromonas asaccharolytica, Acutalibacter timonensis, Turicibacter sanguinis, Alistipes sp., Bacteroides coprocola, Dialister invisus.In certain embodiments, Consortia A and Consortia B comprise strains with the function of each species as described in Figure 26.In certain embodiments, Consortia A and Consortia B further comprise one or more O. formigenes strains. In certain embodiments, Consortia A and Consortia B comprise strains with the function of each species as described in Figure 26 and one or more O. formigenes strains.In certain embodiments, a Consortia comprises a microbial strain having a relative abundance of approximately 90%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, 10%, 5%, 1%, 0.1%, 0.01%, 0.001%, 0.0001%, 0.00001%, or 0.000001% of the total microbial consortium. In certain embodiments, the relative abundance of a microbial strain is determined by metagenomic sequencing and calculated as the percentage of reads that are classified as an identified microbial strain, divided by the genome size. In certain embodiments, the relative abundance of a microbial strain of the present disclosure is determined by metagenomic shotgun sequencing.Active and Supportive Community of MicrobesThe Consortia described herein comprise a plurality of active microbes.Furthermore, the Consortia of the present disclosure further comprise a supportive community of microbes that enhances one or more characteristic of the plurality of active microbes. For example, in certain non-limiting embodiments, the supportive community of microbes enhances gastrointestinal engraftment of the plurality of active microbes. In other embodiments, the supportive community of microbes enhances biomass of the plurality of active microbes. In other embodiments, the supportive community of microbes enhances metabolism of the first metabolic substrate by the plurality of active microbes. In other embodiments, the supportive community of microbes enhances longitudinal stability of the plurality of active microbes.The supportive community of microbes disclosed herein metabolize one or more metabolite produced by the plurality of active microbes, wherein the one or more metabolite inhibits metabolism of the plurality of active microbes. For example, in certain non-limiting embodiments, the supportive community of microbes metabolizes formate produced by the plurality of active microbes, wherein the presence of formate inhibits the metabolism of oxalate by the plurality of active microbes. In certain embodiments, the supportive community of microbes of the current disclosure catalyzes the fermentation of polysaccharides to one or more of the group consisting of acetate, acetoin, 2-oxoglutarate, propionate, 1,3 -propanediol, succinate, ethanol, lactate, butyrate, 2,3-butanediol, acetone, butanol, formate, H2, and CO2. In certain embodiments, the supportive community of microbes catalyzes the fermentation of amino acidsto one or more of the group consisting of acetate, propionate, butanoate, butyrate, isobutyrate, 2- methylbutyrate, isovalerate, isocaproate, 3-phenylpropanoate, phloretate, 3-(lH-indol-3- yl)propanoate, 5-aminopentanoate, H2, H2S, and CO2. In certain embodiments, the supportive community catalyzes the synthesis of one or more of the group consisting of methane from H2 and CO2, methane from formate and H2, acetate from H2 and CO2, acetate from formate and H2, acetate and sulfide from H2, CO2, and sulfate, propionate and CO2 from succinate, succinate from H2 and fumarate; synthesis of succinate from formate and fumarate, and butyrate, acetate, H2, and CO2 from lactate. In certain embodiments, the supportive community of microbes of the current disclosure catalyzes the deconjugation of conjugated bile acids to produce primary bile acids, the conversion of cholic acid (CA) to 7-oxocholic acid, the conversion of 7-oxocholic acid to 7-beta- cholic acid (7betaCA), the conversion of chenodeoxycholic acid (CDCA) to 7- oxochenodeoxycholic acid, and / or the conversion of 7-oxochenodeoxycholic acid to ursodeoxycholic acid (UDCA).Consortia DesignIn certain embodiments, microbial consortia disclosed herein are designed to meet one or more of the following criteria:(i) an ability to eliminate or reduce levels of a first metabolic substrate causing or contributing to a disease in an animal;(ii) an ability to metabolize or convert one or more metabolite produced by the metabolism of the first metabolic substrate;(iii) an ability to metabolize one or more nutrient typically found in the human diet;(iv) an ability to fulfill unique and potentially beneficial biological functions in the gastrointestinal (GI) tract (e.g., bile salt hydrolase activity or butyrate production);(v) an ability to engraft in various biological niches and physical and metabolic compartments of the GI tract of an animal;(vi) an ability to increase biomass upon engraftment in the GI tract;(vii) an ability to have longitudinal stability in the GI tract of an animal;(viii) an ability to increase the flux of a precursor of the first metabolic substrate into a biochemical pathway that converts said precursor into a metabolite that is not the first metabolic substrate;(ix) diversity of component microbial species across one or more taxonomic phyla; and(x) natural prevalence of component microbial species in the GI tract of healthy adults.In certain embodiments, the microbial consortia of the present disclosure are designed to comprise a plurality of active microbes capable of metabolizing a first metabolic substrate that causes or contributes to disease in an animal. In certain embodiments, the first metabolic substratemay be selected from, but not limited to, oxalate and a bile acid (e.g., lithocholic acid (LCA), deoxycholic acid (DCA)). In certain embodiments, the microbial consortium is designed to be capable of metabolizing the first metabolic substrate across a variety of pH ranges found within the GI tract (e.g., pH 4 to 8). In certain embodiments, the microbial consortium is designed to be capable of metabolizing the first metabolic substrate in the presence of various concentrations of first metabolic substrate as they exist in different regions of the GI tract.In certain embodiments, the Consortia is FB-001 (e.g., disclosed in Table 1) or a functional equivalent thereof. In certain embodiments, FB-001 is defined by its function. In certain embodiments, FB-001 is defined by its function as set forth in Tables 3 and / or 4. In certain embodiments, FB-001 is defined by its function as set forth in Tables 3 and 4. In certain embodiments, FB-001 is defined by its function as set forth in Table 3 or 4. In certain embodiments, FB-001 is defined by its function as set forth in Tables 14, 15, and 16. In certain embodiments, FB-001 is defined by its function as set forth in one or more of Tables 14, 15, and 16. In certain embodiments, FB-001 is defined by its function as set forth in Tables 3, 4, 14, 15, and 16. In certain embodiments, FB-001 is defined by its function as set forth in one or more of Tables 3, 4, 14, 15, and 16. In certain embodiments, methods for determining function of FB-001 are provided in Examples 5 and 6.In certain embodiments, the Consortia is FB-003 (e.g., disclosed in Table 2) or a functional equivalent thereof. In certain embodiments, FB-003 is defined by its function. In certain embodiments, FB-003 is defined by its function as set forth in Tables 3 and / or 4. In certain embodiments, FB-003 is defined by its function as set forth in Tables 3 and 4. In certain embodiments, FB-003 is defined by its function as set forth in Table 3 or 4. In certain embodiments, FB-003 is defined by its function as set forth in Tables 14, 15, and 16. In certain embodiments, FB-003 is defined by its function as set forth in one or more of Tables 14, 15, and 16. In certain embodiments, FB-003 is defined by its function as set forth in Tables 3, 4, 14, 15, and 16. In certain embodiments, FB-003 is defined by its function as set forth in one or more of Tables 3, 4, 14, 15, and 16.In certain embodiments, the Consortia is Consortia A or B or a functional equivalent thereof. In certain embodiments, Consortia A and B are defined by its function. In certain embodiments, FB-003 is the consortia of Consortia A or Consortia B. In certain embodiments,Consortia A and B are defined by its function as set forth in Tables 3 and / or 4. In certain embodiments, Consortia A and B are defined by its function as set forth in Tables 3 and 4. In certain embodiments, Consortia A and B are defined by its function as set forth in Table 3 or 4. In certain embodiments, Consortia A and B are defined by its function as set forth in Tables 14, 15, and 16. In certain embodiments, Consortia A and B are defined by its function as set forth inone or more of Tables 14, 15, and 16. In certain embodiments, Consortia A and B are defined by its function as set forth in Tables 3, 4, 14, 15, and 16. In certain embodiments, Consortia A and B are defined by its function as set forth in one or more of Tables 3, 4, 14, 15, and 16.Methods of PreparationThe present disclosure also provides methods for preparing and / or manufacturing the microbial consortia described herein. Figures 10-12 illustrate certain methods for the preparation and manufacturing of the microbial consortia described herein.In certain embodiments, the methods comprise obtaining a donor stool and preparing a stool dilution. In certain embodiments, the stool dilution is plated onto an agar plate. In certain embodiments, the agar plate includes an anaerobic media. In certain embodiments, the agar plate includes colonies. Characterization and quality analysis of these colonies can be performed. For example, but without any limitation, 16s RNA and / or MALDI mass spectrometry could be performed. In certain embodiments, the characterized colonies can be further expanded in a broth culture. After growth and expansion, the microbes can be stored in vials for further use.In certain embodiments, the microbes can be further expanded in a bioreactor including a cell culture medium. In certain embodiments, the cell culture medium can include: a) soytone, D-cellobiose, yeast extract, dextrose (glucose), maltose monohydrate, magnesium sulfate heptahydrate, calcium chloride dihydrate, potassium phosphate monobasic, potassium phosphate dibasic, sodium chloride, sodium bicarbonate, volatile fatty acid solution, L- cysteine HC1 monohydrate, hemin solution, vitamin solution, or a combination thereof; or b) soytone, D-cellobiose, yeast extract, dextrose (glucose), maltose monohydrate, magnesium sulfate heptahydrate, calcium chloride dihydrate, potassium phosphate monobasic, potassium phosphate dibasic, sodium chloride, ammonium sulfate, sodium bicarbonate, volatile fatty acid solution, L-cysteine HC1 monohydrate, hemin solution, vitamin solution, or a combination thereof.In certain embodiments, the cell culture medium is YCFAC. In certain embodiments, the cell culture medium further comprises threonine.In certain embodiments, the microbes can be expanded in a bioreactor in anaerobic conditions. In certain embodiments, the microbes can be expanded in a bioreactor in the presence of gas overlay. In certain embodiments, the microbes can be expanded in a bioreactor in absence of gas sparing.In certain embodiments, the methods include expanding microbes in mixed cultures.In certain embodiments, the methods comprise expanding microbes in a first mixed culture or composition comprising:a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum,Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides fmegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris,Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum, Blautia hydrogenotrophica, andLachnospiraceae sp. FBI00290, or a functional equivalent thereof; or b) FBI00001, FBI00002, FBI00010, FBI00013, FBI00029, FBI00032, FBI00033, FBI00034, FBI00043, FBI00044, FBI00048, FBI00050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FBI00117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FBI00206, FBI00211, FBI00220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof.In certain embodiments, the methods comprise expanding microbes in a second mixed culture or composition comprising: a) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutterella wadsworthensis, Sutterella massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatiformans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa,Eubactenum siraeum, Faecalibactenum prausmtzn, Tuncibacter sanguinis, Eubactenum rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; or b) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FB 100038,FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081,FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140,FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224,FBI00226, FBI00229, FB 100233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof.In certain embodiments, the methods comprise expanding microbes in a third mixed culture or composition comprising: a) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiellatayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; or b) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126, FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereofIn certain embodiments, the methods comprise expanding microbes in a fourth mixed culture or composition comprising: a) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereof; orb) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereofIn certain embodiments, the methods include expanding each of the three O. formigenes microbes of FB-001 in single cultures. In certain embodiments, the methods comprise expanding microbes in a first single culture (or fifth composition) comprising a) a first O. formigenes strain; or b) FBI00067 or a functional equivalent thereof. In certain embodiments, the methods comprise expanding microbes in a second single culture (or sixth composition) comprising a) a second O. formigenes strain; orb) FBI00133 or a functional equivalent thereof. In certain embodiments, the methods comprise expanding microbes in a third single culture (or seventh composition) comprising a) a third O. formigenes strain; or b) FB 100289 or a functional equivalent thereof.In certain embodiments, the methods comprise lyophilizing cultures and compositions described herein. In certain embodiments, the cultures and compositions comprises a lyoprotectant. In certain embodiments, the lyoprotectant comprises maltodextrin. In certain embodiments, the lyoprotectant comprises inulin. In certain embodiments, the lyoprotectant comprises maltodextrin and inulin. In certain embodiments, the maltodextrin is present at a concentration of about 8%. In certain embodiments, the inulin is present at a concentration of about 0.5%.In certain embodiments, the methods comprise blending and / or mixing lyophilized cultures and compositions outlined above. Additional information on the strains for each composition can be found in Table 1 or Table 2.In certain embodiments, DS1 as described in Table 1 is prepared using the method described in Figure 17. In certain embodiments, DS2 as described in Table 1 is prepared using the method described in Figure 18. In certain embodiments, DS3 as described in Table 1 is prepared using the method described in Figure 19. In certain embodiments, DS4 as described in Table 1 is prepared using the method described in Figure 20. In certain embodiments, for FB- 001, DS5-DS7 (i.e., the manufacture of O. formigenes) as described in Table 21 are prepared using the method described in Figure 16. In certain embodiments, the manufacture of FB-001 and FB- 003 comprisethe separate manufacture of each of DS1-DS4 (and DS5-DS7 for FB-001) as described in Figures 16-20, followed by blending to achieve a uniform distribution of each of the DSs. In certain embodiments, the blending of DS1-DS4 (for FB-003) and DS1-DS7 (for FB-003) is followed by encapsulation for oral administration.Pharmaceutical CompositionsThe present disclosure also provides pharmaceutical compositions that contain an effective amount of a microbial consortium described herein. The composition can be formulated for usein a variety of delivery systems. One or more physiologically acceptable buffer(s) or carrier(s) can also be included in the composition for proper formulation. Suitable formulations for use in the present disclosure are found in Remington's Pharmaceutical Sciences, Mack Publishing Company, Philadelphia, Pa., 17th ed., 1985. For a brief review of methods for drug delivery, see, e.g., Langer (Science 249: 1527-1533, 1990).In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia I. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia II. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia I. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia III. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia IV. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia V. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia VI. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia VII. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia VIII. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia IX. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia X. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia XI. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia XII. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia XIII. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia XIV. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia XV. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia XVI. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia XVII. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia XVIII. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia XIX. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia A. In certain embodiments, the presently disclosed pharmaceutical composition comprises Consortia B.In certain embodiments, the presently disclosed pharmaceutical composition comprises FB-001. In certain embodiments, the presently disclosed pharmaceutical composition comprises FB-003.In certain embodiments, the presently disclosed pharmaceutical composition comprises an amount of at least about 10, at least about 102, at least about 103, at least about 104, at least aboutIO5, at least about 106, at least about 107, at least about 108, at least about 109, at least about IO10, at least about 1011, at least about 1012, or at least about 1013microbes of each strain (e.g., each strain of FB-001 or FB-003). In certain embodiments, the presently disclosed pharmaceutical composition comprises between about 10 and about 1013, between about 102and about 1013, between about 103and about 1013, between about 104and about 1013, between about 105and about 1013, between about 106and about 1013, between about 107and about 1013, between about 108and about 1013, between about 109and about 1013, between about IO10and about 1013, between about 1011and about 1013, between about 1012and about 1013, between about 102and about 1012, between about 102and about 1011, between about 102and about IO10, between about 102and about 109, between about 102and about 108, between about 102and about IO7, between about 102and about 106, between about 102and about 105, between about 102and about 104, between about 102and about 103, between about 102and about 109, between about 103and about 109, between about 104and about 109, between about 105and about 109, between about 106and about 109, between about 107and about 109, between about 108and about 109, between about 102and about 106, between about 103and about 106, between about 104and about 106, or between about 105and about 106microbes for each strain (e.g., each strain of FB-001 or FB-003). In certain embodiments, each strain can be present in different amounts. For example, but without any limitation, a pharmaceutical composition comprising a first strain, a second strain, and a third strain can comprise 10 microbes of the first strain, 107microbes of the second strain, 103microbes of the third strain.In certain embodiments, the presently disclosed pharmaceutical composition comprises an amount of at least about 10, at least about 102, at least about 103, at least about 104, at least about 105, at least about 106, at least about 107, at least about 108, at least about 109, at least about IO10, at least about 1011, at least about 1012, or at least about 1013CFUs of each strain (e.g., each strain of FB-001 or FB-003). In certain embodiments, the presently disclosed pharmaceutical composition comprises between about 10 and about 1013, between about 102and about 1013, between about 103and about 1013, between about 104and about 1013, between about 105and about 1013, between about 106and about 1013, between about 107and about 1013, between about 108and about 1013, between about 109and about 1013, between about IO10and about 1013, between about 1011and about 1013, between about 1012and about 1013, between about 102and about 1012, between about 102and about 1011, between about 102and about IO10, between about 102and about 109, between about 102and about 108, between about 102and about IO7, between about 102and about 106, between about 102and about 105, between about 102and about 104, between about 102and about 103, between about 102and about 109, between about 103and about 109, between about 104and about 109, between about 105and about 109, between about 106and about 109, betweenabout 107and about 109, between about 108and about 109, between about 102and about 106, between about 103and about 106, between about 104and about 106, or between about 105and about 106CFUs for each strain (e.g., each strain of FB-001 or FB-003). In certain embodiments, each strain can be present in different amounts. For example, but without any limitation, a pharmaceutical composition comprising a first strain, a second strain, and a third strain can comprise 10 CFUs of the first strain, 107CFUs of the second strain, 103CFUs of the third strain.In certain embodiments, the presently disclosed pharmaceutical composition comprises an amount of at least about 10’1, at least about 10'2, at least about 10'3, at least about 10'4, at least about 10’5, at least about 10'6, at least about 10'7, at least about 10'8, at least about 10'9, at least about IO10, at least about 1011, or at least about 1012, or at least about 1013grams of each strain (e.g., each strain of FB-001 or FB-003). In certain embodiments, each strain can be present in different amounts. For example, but without any limitation, a pharmaceutical composition comprising a first strain, a second strain, and a third strain can comprise 10’4grams of the first strain, 1 O'3grams of the second strain, 1 O'6grams of the third strain.In certain embodiments, the presently disclosed pharmaceutical composition comprises a total amount of at least about 10, at least about 102, at least about 103, at least about 104, at least about 105, at least about 106, at least about 107, at least about 108, at least about 109, at least about IO10, at least about 1011, at least about 1012, or at least about 1013microbes (e.g., total amount of microbes of FB-001 or total amount of microbes FB-003). In certain embodiments, the presently disclosed pharmaceutical composition comprises a total amount of between about 10 and about 1013, between about 102and about 1013, between about 103and about 1013, between about 104and about 1013, between about 105and about 1013, between about 106and about 1013, between about 107and about 1013, between about 108and about 1013, between about 109and about 1013, between about IO10and about 1013, between about 1011and about 1013, between about 1012and about 1013, between about 102and about 1012, between about 102and about 1011, between about 102and about IO10, between about 102and about 109, between about 102and about 108, between about 102and about 107, between about 102and about 106, between about 102and about 105, between about 102and about 104, between about 102and about 103, between about 102and about 109, between about 103and about 109, between about 104and about 109, between about 105and about 109, between about 106and about 109, between about 107and about 109, between about 108and about 109, between about 102and about 106, between about 103and about 106, between about 104and about 106, or between about 105and about 106microbes.In certain embodiments, the presently disclosed pharmaceutical composition comprises a total amount of at least about 10, at least about 102, at least about 103, at least about 104, at least about 105, at least about 106, at least about 107, at least about 108, at least about 109, at least aboutIO10, at least about IO11, at least about 1012, or at least about 1013CFUs (e.g., total CFUs of FB- 001 or total CFUs of FB-003). In certain embodiments, the presently disclosed pharmaceutical composition comprises a total amount of between about 10 and about 1013, between about 102and about 1013, between about 103and about 1013, between about 104and about 1013, between about 105and about 1013, between about 106and about 1013, between about 107and about 1013, between about 108and about 1013, between about 109and about 1013, between about IO10and about 1013, between about 1011and about 1013, between about 1012and about 1013, between about 102and about 1012, between about 102and about 1011, between about 102and about IO10, between about 102and about 109, between about 102and about 108, between about 102and about 107, between about 102and about 106, between about 102and about 105, between about 102and about 104, between about 102and about 103, between about 102and about 109, between about 103and about 109, between about 104and about 109, between about 105and about 109, between about 106and about 109, between about 107and about 109, between about 108and about 109, between about 102and about 106, between about 103and about 106, between about 104and about 106, or between about 105and about 106CFUs. In certain embodiments, the presently disclosed pharmaceutical composition comprises between about 105and about 1013, between about 106and about 1013, between about 107and about 1013, between about 108and about 1013, between about 109and about 1013, between about IO10and about 1013, between about 1011and about 1013, between about 1012and about 1013, between about 105and about 1012, between about 106and about 1012, between about 107and about 1012, between about 108and about 1012, between about 109and about 1012, between about IO10and about 1012, between about 1011and about 1012, between about 105and about 1011, between about 106and about 1011, between about 107and about 1011, between about 108and about 1011, between about 109and about 1011, between about IO10and about 1011, between about 105and about IO10, between about 106and about IO10, between about 107and about IO10, between about 108and about IO10, between about 109and about IO10, between about 105and about 109, between about 106and about 109, between about 107and about 109, between about 108and about 109, between about 5 x io9and about 5 x io10, between about 5 x io9and about 5 x 1011, between about 5 x io9and about 5 x io12, between about 5 x io10and about 5 x io12, between about 5 x io11and about 5 x 1012, or between about 5 x io10and about 5 x io11viable cells. In certain embodiments, the presently disclosed pharmaceutical composition comprises between about 5 x io9and about 5 x io12viable cells. In certain embodiments, the presently disclosed pharmaceutical composition comprises between about 5 x io9and about 5 x io10viable cells. In certain embodiments, the presently disclosed pharmaceutical composition comprises between about 5 x io10and about 5 x io11viable cells. In certain embodiments, the presently disclosed pharmaceutical composition comprises between about 5 x io11and about 5 x io12viable cells.In certain embodiments, the presently disclosed pharmaceutical composition comprises up to about 105, up to about 106, up to about 107, up to about 108, up to about 109, up to about IO10, up to about 1011, up to about 1012, or up to about 1013viable cells. In certain embodiments, the presently disclosed pharmaceutical composition comprises up to about 1011viable cells. In certain embodiments, the presently disclosed pharmaceutical composition comprises up to about 1012viable cells.In certain embodiments, the presently disclosed pharmaceutical composition can be present in the form of a food product comprising a consortia disclosed herein (e g., FB-001 or FB- 003). As used herein, the term “food product” refers to a composition intended for ingestion by an individual (e.g., a human subject). Non-limiting examples of food products encompassed by the present disclosure include juices, refreshing beverages, tea beverages, drink preparations, jelly beverages, functional beverages, milk, dairy beverages, ice creams, cheeses, yogurts, biscuits, cookies, candies, chewing gums, gummies, jellies, cream caramels, frozen desserts, and instant foods. Further, the examples also include health foods and beverages prepared in the forms of powders, granules, tablets, capsules, liquids, pastes, and jellies. In certain embodiments, the food product comprising a presently disclosed consortia further comprises a prebiotic. As used herein, the term “prebiotic” refers to a substance that can promote the growth of the microbes of the consortia. Non-limiting examples of prebiotic include fructose, galactose, mannose, soy, inulin, dietary fibers, or a combination thereof.In certain embodiments, microbial cells of the present disclosure are harvested by microfiltration and centrifugation. In certain embodiments, microfiltration is done with a membrane comprising a nonreactive polymer. For example, in certain non-limiting embodiments, said membrane comprises Polyvinylidene fluoride, Polysulfones, or nitrocellulose. In certain embodiments, a membrane for microfiltration has a pore size from about 0.2 pm to about 0.45 pm. In certain embodiments, the cells are centrifuged at from about 1000 g to about 30000 g, from about 5000 g to about 30000 g, from about 10000 g to about 30000 g, from about 15000 g to about 30000 g, from about 20000 g to about 30000 g, from about 25000 g to about 30000 g, from about 1000 g to about 25000 g, from about 5000 g to about 25000 g, from about 10000 g to about 25000 g, from about 15000 g to about 25000 g, from about 20000 g to about 25000 g, from about 1000 g to about 20000 g, from about 5000 g to about 20000 g, from about 10000 g to about 20000 g, from about 15000 g to about 20000g, from about 1000 g to about 15000 g, from about 5000 g to about 15000 g, from about 10000 g to about 15000 g, from about 1000 g to about 10000 g, from about 5000 g to about 10000 g, or from about 1000 g to about 5000 g force.In certain embodiments, the cells are concentrated to from about 1 x 106CFUs per milliliter to about 1x1012CFUs per milliliter, from about 1 x 107CFUs per milliliter to about 1x 1012CFUs per milliliter, from about 1 x 108CFUs per milliliter to about 1 x 1012CFUs per milliliter, from about 1 x 109CFUs per milliliter to about 1x1012CFUs per milliliter, from about 1 x io10CFUs per milliliter to about 1 x 1012CFUs per milliliter, from about 1 x 1011CFUs per milliliter to about 1x1012CFUs per milliliter, from about 1 x io6CFUs per milliliter to about 1 x 1011CFUs per milliliter, from about 1 x 107CFUs per milliliter to about 1x1011CFUs per milliliter, from about 1 x 108CFUs per milliliter to about 1 x 1011CFUs per milliliter, from about 1 x io9CFUs per milliliter to about 1x1011CFUs per milliliter, from about 1x1O10CFUs per milliliter to about 1x1011CFUs per milliliter, from about 1 x 106CFUs per milliliter to about 1 x IO10CFUs per milliliter, from about 1 x 107CFUs per milliliter to about 1 x 1O10CFUs per milliliter, from about 1 x 108CFUs per milliliter to about 1 x 1O10CFUs per milliliter, from about 1 x 109CFUs per milliliter to about 1x1O10CFUs per milliliter, from about 1 x 106CFUs per milliliter to about 1 x 109CFUs per milliliter, from about 1 x 107CFUs per milliliter to about 1 x 109CFUs per milliliter, from about 1 x 108CFUs per milliliter to about 1 x 109CFUs per milliliter, from about 1x106CFUs per milliliter to about 1x108CFUs per milliliter, from about 1x107CFUs per milliliter to about 1 x 108CFUs per milliliter, or from about 1 x 106CFUs per milliliter to about 1 x io7CFUs per milliliter.In certain embodiments, microbial cells of the present disclosure are frozen. In certain embodiments, the microbial cells of the present disclosure are mixed with one or more cryoprotective agents (CPAs) before freezing. In certain embodiments, the ratio of cells to CPA is approximately 25:1, 10:1, 5:1, 4: 1, 3:1, 2:1, 1: 1, 1 :2, 1:3, 1:4, 1 :5, 1:10, or 1:25. In certain embodiments, a CPA comprises one or more of glycerol, maltodextrin, sucrose, inulin, trehalose, and alginate. In certain embodiments, a CPA further comprises one or more antioxidants. In certain embodiments, an antioxidant is selected from the list of cysteine, ascorbic acid, and riboflavin.In certain embodiments, the microbial cells of the present disclosure are lyophilized. In certain embodiments, the lyophilized cells are used to make an orally-administered dose of the disclosure. In certain embodiments, primary drying is conducted below approximately -20 °C. In certain embodiments, primary drying is followed by a secondary drying at a higher temperature, e.g. greater than 0 °C, greater than 5 °C, or greater than 10 °C.Functionally Equivalent and Identical Drug Products to FB-001The strains included in FB-001 are described herein by 16S RNA sequences and functional characteristics. Based on this, equivalent Consortia to FB-001 can be generated by screening multiple of the same strain to find equivalent strains with equivalent function to those that comprise FB-001. Accordingly, identical strains may theoretically have different functions, strains can be screened using 16S RNA and Biolog as described herein to identify functionallyidentical and equivalent strains from any fecal collection using the methods of collection described herein.It is important to note that FB-001 was articulately designed to have multiple of the same strain in the Consortia. The reason for this to have redundancy to ensure function; however, such redundancy is not required for equivalent function so long as one of the otherwise redundant strains is included in the final drug product at a sufficient viable cell count amount to achieve in vivo function in a subject. Accordingly, a Consortia that is equivalent or identical to FB-001 may contain all redundancies (see Table 1) or alternatively may contain no or fewer redundancies per strain so long as the included strains achieve in vivo function in a subject.In an alternative approach to creating a functionally equivalent Consortia to FB-001, one of skill in the art could recreate a consortia of supportive microbes from healthy fecal donors and supplement the supportive microbes with one or more O. formigenes strains. In certain embodiments, the supportive microbes will be supplemented with two or more O. formigenes strains or specifically three O. formigenes strains. The supportive microbes may comprise anywhere between 10 and 200 microbes so long as such supportive community supports and encourages the growth, health, and engraftment of the O. formigenes strain(s) in a subject. FB- 001 was designed to have 148 microbes to mimic a complete, healthy microbiome. Accordingly, equivalent Consortia may comprise approximately 148 microbes, including O. formigenes strain(s). However, it is interesting to note that older subjects often have smaller microbiomes; accordingly, a functionally equivalent Consortia to FB-001 may also have far fewer microbes (e.g., 30-40, 40-50, 50-60, 60-70, 70-80, 8-90, 90-100, 100-110, 110-120, 120-130, 130-140, or 140-150 microbes, including O. formigenes strain(s)).Functionally Equivalent and Identical Drug Products to FB-003The strains included in FB-003 are described herein by 16S RNA sequences and functional characteristics. Based on this, equivalent Consortia to FB-003 can be generated by screening multiple of the same strain to find equivalent strains with equivalent function to those that comprise FB-003. Accordingly, identical strains may theoretically have different functions, strains can be screened using 16S RNA and Biolog as described herein to identify functionally identical and equivalent strains from any fecal collection using the methods of collection described herein.It is important to note that FB-003 was articulately designed to have multiple of the same strain in the Consortia. The reason for this to have redundancy to ensure function; however, such redundancy is not required for equivalent function so long as one of the otherwise redundant strains is included in the final drug product at a sufficient viable cell count amount to achieve in vivo function in a subject. Accordingly, a Consortia that is equivalent or identical to FB-003 maycontain all redundancies (see Table 2) or alternatively may contain no or fewer redundancies per strain so long as the included strains achieve in vivo function in a subject.Therapeutic ApplicationsThe present disclosure provides Consortia capable of engrafting into one or more niche of a gastrointestinal tract where it is capable of treating dysbiosis that causes or contributes to disease in an animal. In certain embodiments, the animal is a human.In certain embodiments of the disclosure, when administered to an animal, the animal is pre-treated with one or more antibiotics prior to administration of the Consortium. In certain embodiments, the one or more antibiotics is selected from ampicillin, enrofloxacin, clarithromycin, and metronidazole. In certain embodiments, the animal is pre-treated with a polyethylene glycol bowel -preparation procedure.In certain embodiments, a Consortia is used to treat a subject having or at risk of developing dysbiosis of the gastrointestinal tract. In certain embodiments, the dysbiosis is caused by or causes irritable bowel disease ( BD), colitis, ulcerative colitis, or Crohn’s disease. In certain embodiments, the dysbiosis is caused by or causes IBD. In certain embodiments, the dysbiosis is caused by or causes colitis. In certain embodiments, the dysbiosis is caused by or causes ulcerative colitis. In certain embodiments, the dysbiosis is caused by or causes Crohn’s disease.In certain embodiments, a Consortia significantly alters the profile and / or concentration of bile acids present in an animal. For example, in certain non-limiting embodiments, a Consortia significantly alters the profile and / or concentration of T -MCA, Ta-MCA, TUDCA, THDCA, TCA, 7P-CA, 7-oxo-CA, TCDCA, Tco-MCA, TDCA, a-MCA, -MCA, co-MCA, Muro-CA, d4- CA, CA, TLCA, UDCA, HDCA, CDCA, DCA, and LCA in an animal. In certain embodiments, FB-003 alters the profile and / or concentration of one or more of TP-MCA, Ta-MCA, TUDCA, THDCA, TCA, 7 -CA, 7-oxo-CA, TCDCA, Tco-MCA, TDCA, a-MCA, -MCA, co-MCA, Muro- CA, d4-CA, CA, TLCA, UDCA, HDCA, CDCA, DCA, and LCA in an animal.In certain embodiments, a high-complexity defined gut microbial community of the present disclosure can be used to treat an animal having a cholestatic disease, such as, for example, primary sclerosing cholangitis, primary biliary cholangitis, progressive familial intrahepatic cholestasis, or nonalcoholic steatohepatitis. For example, in certain non-limiting embodiments, the animal may be a mammal, and more particularly a human.In certain embodiments, a Consortia can be administered via an enteric route. For example, in certain non-limiting embodiments, a microbial consortium is administered orally, rectally (e.g., by enema, suppository, or colonoscope), or by oral or nasal tube.In certain embodiments, a Consortia is administered orally. In certain embodiments the oral administration is by a powder. In certain embodiments the oral administration is by a slurry. In certain embodiments the oral administration is by pills or capsules.In certain embodiments, a Consortia can be administered to a specific location along the gastrointestinal tract. For example, in certain non-limiting embodiments, a microbial consortium can be administered into one or more gastrointestinal location including the mouth, esophagus, stomach, small intestine (duodenum, jejunum, ileum), large intestine (cecum, ascending colon, transverse colon, descending colon), or rectum. In certain embodiments, a microbial consortium can be administered in all regions of the gastrointestinal tract.In certain embodiments, FB-001 and FB-003 can be administered orally via a pill or capsule.Methods of Treating Dysbiosis and IBDThe present disclosure provides methods for preventing and / or treating dysbiosis in a subject. In certain embodiments, the methods can comprise administering an effective amount of a Consortia or a pharmaceutical composition thereof disclosed herein. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in the engraftment of the microbes of the Consortia. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in the microbial diversity of the gastrointestinal tract. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase of short chain fatty acids (SCFAs) (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in secondary bile acids (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in decrease of bacterial pathogens (e.g., in the gastrointestinal tract of the subject).The present disclosure also provides methods for decreasing dysbiosis (e.g., dysbiosis of the gastrointestinal tract) in a subject. In certain embodiments, the methods can comprise administering an effective amount of a Consortia or pharmaceutical composition thereof disclosed herein. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in the engraftment of the microbes of the Consortia. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in the microbialdiversity of the gastrointestinal tract. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase of short chain fatty acids (SCFAs) (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in secondary bile acids (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in decrease of bacterial pathogens (e.g., in the gastrointestinal tract of the subject).Further, the present disclosure provides methods for restoring microbiome in a subject. In certain embodiments, the methods can comprise administering an effective amount of a Consortia or pharmaceutical composition thereof disclosed herein. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in the engraftment of the microbes of the Consortia. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in the microbial diversity of the gastrointestinal tract. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase of short chain fatty acids (SCFAs) (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in secondary bile acids (e g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in decrease of bacterial pathogens (e g., in the gastrointestinal tract of the subject).Moreover, the present disclosure provides methods for recovery of a healthy microbiome in a subject undergone to a dysbiosis-inducing event. In certain non-limiting embodiments, for example and without any limitation, the dysbiosis-inducing event can be an antibiotic treatment, an infectious disease, or an underlying disease. In certain non-limiting embodiments, the underlying disease can be IBD, colitis, ulcerative colitis, or Crohn’s disease. In certain embodiments, the methods can comprise administering an effective amount of a Consortia or pharmaceutical composition thereof disclosed herein. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in the engraftment of the microbes of the Consortia. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in the microbial diversity of the gastrointestinal tract. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase of short chain fatty acids (SCFAs) (e.g., in the gastrointestinal tract of the subject). Incertain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in secondary bile acids (e g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in decrease of bacterial pathogens (e.g., in the gastrointestinal tract of the subject).The present disclosure further provides methods for reducing a severity of at least one symptom of a gastrointestinal disease (e.g., associated with dysbiosis of the gastrointestinal tract) in a subject. Non-limiting examples of gastrointestinal diseases include irritable bowel syndrome, diarrhea, constipation, celiac disease, and leaky gut syndrome. In certain embodiments, the methods can comprise administering an effective amount of a Consortia or pharmaceutical composition thereof disclosed herein. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in the engraftment of the microbes of the Consortia. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in the microbial diversity of the gastrointestinal tract. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase of short chain fatty acids (SCFAs) (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in secondary bile acids (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in decrease of bacterial pathogens (e.g., in the gastrointestinal tract of the subject).The present disclosure further provides methods for treating a disease in a subject. In certain embodiments, the disease is irritable bowel syndrome, diarrhea, constipation, celiac disease, and leaky gut syndrome, colitis, ulcerative colitis, or Crohn’s disease. In certain embodiments, the methods can comprise administering an effective amount of a Consortia or pharmaceutical composition thereof disclosed herein. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in the engraftment of the microbes of the Consortia. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in the microbial diversity of the gastrointestinal tract. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase of short chain fatty acids (SCFAs) (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in secondary bile acids (e g., in the gastrointestinal tract of the subject). Incertain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in decrease of bacterial pathogens (e.g., in the gastrointestinal tract of the subject).The present disclosure further provides methods for treating Inflammatory Bowel Disease (IBD) in a subject. In certain embodiments, the methods can comprise administering an effective amount of a Consortia or pharmaceutical composition thereof disclosed herein. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in the engraftment of the microbes of the Consortia. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in the microbial diversity of the gastrointestinal tract. In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase of short chain fatty acids (SCFAs) (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in increase in secondary bile acids (e.g., in the gastrointestinal tract of the subject). In certain embodiments, the administration of the Consortia or pharmaceutical composition thereof results in decrease of bacterial pathogens (e.g., in the gastrointestinal tract of the subject).IBD (including colitis, ulcerative colitis, and Crohn’s disease) is a debilitating disease and treatment of which remains a high unmet need despite approved marketed products. It is a disorder characterized by chronic inflammation and hyperpermeability of the gut. There are no known pharmacological cures for IBD; rather, current standard of care treatment relies on control of symptoms, maintenance of remission, prevention of relapse, and palliative care. There are more than 1.7 million IBD patients in the US alone as of 2022 and a disease-modifying therapy with a good tolerability profile would be game changing. There are also no therapies to treat the underlying dysbiosis of IBD.In certain embodiments, FB-001 is a disease-modifying therapy for the treatment of IBD. In certain embodiments, FB-001 treats the underlying dysbiosis of IBD. In certain embodiments, a functional equivalent of FB-001 is a disease-modifying therapy for the treatment of IBD. In certain embodiments, a functional equivalent of FB-001 treats the underlying dysbiosis of IBD.In certain embodiments, FB-003 is a disease-modifying therapy for the treatment of IBD. In certain embodiments, FB-003 treats the underlying dysbiosis of IBD. In certain embodiments, a functional equivalent of FB-003 is a disease-modifying therapy for the treatment of IBD. In certain embodiments, a functional equivalent of FB-003 treats the underlying dysbiosis of IBD.As a result of the dysbiosis in IBD patients, the microbial diversity, the short chain fatty acids (SCFAs), and the secondary bile acids are all reduced while there is an increase in thepresence of bacterial pathogens. In certain embodiments, FB-001 or a functional equivalent thereof can increase (or restore to normal and / or healthy levels) the microbial diversity in an IBD patient, increase the SCFAs in an IBD patient, increase secondary bile acids in IBD patients, and decrease the presence of bacterial pathogens; thereby restoring the gut ecosystem and promoting heathy barrier responses. In certain embodiments, FB-003 or a functional equivalent thereof can increase (or restore to normal and / or healthy levels) the microbial diversity in an IBD patient, increase the SCFAs in an IBD patient, increase secondary bile acids in IBD patients, and decrease the presence of bacterial pathogens; thereby restoring the gut ecosystem and promoting heathy barrier responses.Limitations in the field of IBD microbiome treatments include the low diversity of microbes. For example, certain microbiome treatments for IBD include spore preparations which limit diversity based on the how spores are isolated and manufactured (i.e., the preparation of spores results in a loss of microbial diversity and a complete taxonomic recapitulation of a healthy microbiome is not possible, see e.g., Figure 13) and small defined consortia of fewer than 20 strains (i.e., limited, if any, microbial diversity and no complete or near complete taxonomic recapitulation of a healthy microbiome). In certain embodiments, the Consortia described herein solve the unmet need of a microbiome therapy with taxonomic and functional diversity for the treatment of IBD. In certain embodiments, the Consortia is FB-001 or a functional equivalent thereof. In certain embodiments, the Consortia is FB-003 or a functional equivalent thereof.In certain embodiments, FB-001 or a functional equivalent thereof and FB-003 or a functional equivalent thereof engraft in the gastrointestinal tract of patients. In certain embodiments, FB-001 or a functional equivalent thereof and FB-003 or a functional equivalent thereof robustly engraft in the gastrointestinal tract of patients. In certain embodiments, FB-001 or a functional equivalent thereof and FB-003 or a functional equivalent thereof engraft in the gastrointestinal tract of patients and restore microbial diversity. In certain embodiments, FB-001 or a functional equivalent thereof and FB-003 or a functional equivalent thereof engraft in the gastrointestinal tract of patients and restore key functions of a healthy gut microbiome. In certain embodiments, the key functions are 1) increasing microbial diversity, 2) increasing the SCFAs, 3) increasing secondary bile acids, 4) decreasing the presence of bacterial pathogens, and / or 5) promoting heathy barrier responses.In certain embodiments, a Consortia is used to treat IBD, colitis, ulcerative colitis, and / or Crohn’s disease. In certain embodiments, FB-001 is used to treat IBD, colitis, ulcerative colitis, and / or Crohn’s disease. In certain embodiments, FB-003 is used to treat IBD, colitis, ulcerative colitis, and / or Crohn’s disease.In certain embodiments, a Consortia is administered as a single dose or as multiple doses. In certain embodiments, a Consortia is administered once a day for 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 2 weeks 3 weeks, 1 month, 2 months, 3 months, 4 months, 5 months, 6 months, or 1 year. In certain embodiments, a Consortia is administered multiple times daily. In certain embodiments, a Consortia is administered twice daily, three times daily, 4 times daily, or 5 times daily. In certain embodiments, a Consortia is administered intermittently. In certain embodiments, a Consortia is administered once weekly, once monthly, or when a subject is in need thereof. In certain embodiments, the Consortia is FB-001 or FB-003. In certain embodiments, the Consortia is FB-003.In certain embodiments, a Consortia is administered at an effective dose to allow for engraftment and substrate metabolism. In certain embodiments, a Consortia is administered at an effective dose to allow for engraftment and significant SCFA production. In certain embodiments, a Consortia is administered at an effective dose to allow for engraftment and reduced inflammation of the gastrointestinal tract.In certain embodiments, a Consortia is administered at a first loading dose and then followed by maintenance doses. In certain embodiments, the first loading dose is administered for 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, or 10 days. In certain embodiments, the loading dose is administered for 1-3 days. In certain embodiments, the loading dose is administered for 2-4 days. In certain embodiments, the loading dose is administered for 2- 3 days. In certain embodiments, the loading dose is administered for 3-5 days. In certain embodiments, the loading dose is administered for 4-6 days. In certain embodiments, the loading dose is administered for 5-7 days. In certain embodiments, the loading dose is administered for 1 day. In certain embodiments, the loading dose is administered for 3 days. In certain embodiments, the loading dose is administered for 2 days. In certain embodiments, the maintenance doses are administered for 5-10 days following the last loading dose. In certain embodiments, the maintenance doses are administered for 7-12 days following the last loading dose. In certain embodiments, the maintenance doses are administered for 10-14 days following the last loading dose. In certain embodiments, the maintenance doses are administered for 14-21 days following the last loading dose. In certain embodiments, the maintenance doses are administered for 21-28 days following the last loading dose. In certain embodiments, the maintenance doses are administered for 14 days following the last loading dose. In certain embodiments, the maintenance doses are administered for 21 days following the last loading dose. In certain embodiments, the maintenance doses are administered for 28 days following the last loading dose. In certain embodiments, the maintenance doses are administered for about 8 days following the last loading dose. In certain embodiments, the maintenance doses are administered for about 7days following the last loading dose. In certain embodiments, the maintenance doses are administered for about 6 days following the last loading dose. In certain embodiments, the maintenance doses are administered for about 9 days following the last loading dose. In certain embodiments, the maintenance doses are administered for about 10 days following the last loading dose. In certain embodiments, the loading dose is administered for 2 days and the maintenance dose is administered for 6 days (for a total of a 8-day course of treatment). In certain embodiments, the loading dose is administered for 2 days and the maintenance dose is administered for 7 days (for a total of a 9-day course of treatment). In certain embodiments, the loading dose is administered for 2 days and the maintenance dose is administered for 8 days (for a total of a 10 day course of treatment). In certain embodiments, the loading dose is administered for 9 days and the maintenance dose is administered for 9 days (for a total of a 11 day course of treatment). In certain embodiments, the loading dose is administered for 2 days and the maintenance dose is administered for 10 days (for a total of a 12 day course of treatment). In certain embodiments, the Consortia is FB-001. In certain embodiments, the loading dose follows the pretreatment with antibiotics as described in the Combination Therapy section below. In certain embodiments, the loading dose follows the pretreatment with a bowel preparation as described in the Combination Therapy section below. In certain embodiments, the loading dose follows the pretreatment with antibiotics and a bowel preparation as described in the Combination Therapy section below.In certain embodiments, FB-001 is formulated by blending the seven lyophilized DSs containing the 148 microbial species and filling them into coated enteric capsules. In certain embodiments, FB-003 is formulated by blending the four lyophilized DSs containing the 145 microbial species and filling them into coated enteric capsules. In certain embodiments, the capsules of FB-001 or FB-003 are provided in blister packaging or alternative packaging to allow for no or low oxygen exposure (e.g., packaging to sustain the viability of anaerobic microbes). In certain embodiments, each capsule contains a range of 5 x io10to 5 x io11viable cells / capsule. In certain embodiments, each capsule contains a range of 5 x io9to 5 x io10viable cells / capsule. In certain embodiments, each capsule contains a range of 5 * 1011to 5 x io12viable cells / capsule. In certain embodiments, FB-001 or FB-003 is orally dosed at up to 1012viable cells on Days 1 and 2, and up to 1011viable cells on Days 3 to 10. In certain embodiments, maltodextrin is included as an excipient in the capsules.In certain embodiments, each capsule of FB-001 or FB-003 contains a range of 5 x 1O10to 5 x io11viable cells / capsule and a viable cell count basis and with relative abundance values of the 145 (absent O. formigenes which is present only in FB-001) strains ranging from 18% to 0.015%.In certain embodiments, the methods disclose herein comprise diagnosing dysbiosis in the subject and then treating the subject with the Consortia or pharmaceutical composition thereof. For example, but not by way of limitation, a method of treating a subject having dysbiosis can include (a) diagnosing the subject with dysbiosis and (b) administering an effective amount of a Consortia (e.g., FB-001 or FB-003) or pharmaceutical composition thereof to the subject. In certain embodiments, the method for diagnosing dysbiosis includes organic acid test, comprehensive digestive stool analysis (CDSA), hydrogen breath test, or a combination thereof.In certain embodiments, the methods disclose herein comprise diagnosing IBD in the subject and then treating the subject with the Consortia or pharmaceutical composition thereof. For example, but not by way of limitation, a method of treating a subject having IBD can include (a) diagnosing the subject with IBD and (b) administering an effective amount of a Consortia (e.g., FB-001 or FB-003) or pharmaceutical composition thereof to the subj ect. In certain embodiments, the method for diagnosing IBD includes endoscopy, colonoscopy, flexible sigmoidoscopy, upper endoscopy, capsule endoscopy, analysis of c-reactive protein (CPR) in blood sample, analysis of erythrocyte sedimentation rate in blood sample, detection of calprotectin in stool, detection of lactoferrin in stool or a combination thereof.In certain embodiments, the Consortia described herein are used to treat dysbiosis caused by chemical insult. In certain embodiments, the Consortia described herein are used to treat a disease associated with dysbiosis caused by chemical insult. In certain embodiments, FB-003, FB-001, Consortia A or Consortia B described herein are used to treat dysbiosis caused by chemical insult. In certain embodiments, FB-003, FB-001, Consortia A or Consortia B described herein are used to treat a disease associated with dysbiosis caused by chemical insult.In certain embodiments, the Consortia described herein are used to treat dysbiosis caused by inflammation. In certain embodiments, the Consortia described herein are used to treat a disease associated with dysbiosis caused by inflammation. In certain embodiments, FB-003, FB- 001, Consortia A or Consortia B described herein are used to treat dysbiosis caused by inflammation. In certain embodiments, FB-003, FB-001, Consortia A or Consortia B described herein are used to treat a disease associated with dysbiosis caused by inflammation.In certain embodiments, the Consortia described herein are used to treat dysbiosis caused by infectious disease. In certain embodiments, the Consortia described herein are used to treat a disease associated with dysbiosis caused by infectious disease. In certain embodiments, FB-003, FB-001, Consortia A or Consortia B described herein are used to treat dysbiosis caused by infectious disease. In certain embodiments, FB-003, FB-001, Consortia A or Consortia B described herein are used to treat a disease associated with dysbiosis caused by infectious disease.In certain embodiments, the Consortia described herein are used to treat dysbiosis by improving the epithelial barrier of the intestines and / or colon. In certain embodiments, the Consortia described herein are used to treat dysbiosis by fixing the epithelial barrier of the intestines and / or colon. In certain embodiments, the Consortia described herein are used to treat dysbiosis by transforming the epithelial barrier of the intestines and / or colon to that of a healthy individual. In certain embodiments, the Consortia is FB-003, FB-001, Consortia A or Consortia BCombination TherapyIn certain embodiments, a Consortia can be administered in combination with other agents. In certain embodiments, a Consortia can be administered with an antimicrobial agent, an antifungal agent, an antiviral agent, an antiparasitic agent or a prebiotic. In certain embodiments, a Consortia can be administered subsequent to administration of an antimicrobial agent, an antifungal agent, an antiviral agent, an antiparasitic agent or a prebiotic. In certain embodiments, administration may be sequential over a period of hours or days, or simultaneously.For example, in certain non-limiting embodiments, a microbial consortium can be administered with, or pre-administered with, one or more antibacterial agent selected from fluoroquinolone antibiotics (ciprofloxacin, Levaquin, floxin, tequin, avelox, and norflox); cephalosporin antibiotics (cephalexin, cefuroxime, cefadroxil, cefazolin, cephalothin, cefaclor, cefamandole, cefoxitin, cefprozil, and ceftobiprole);penicillin antibiotics (amoxicillin, ampicillin, penicillin V, dicloxacillin, carbenicillin, vancomycin, and methicillin); tetracycline antibiotics (tetracycline, minocycline, oxytetracycline, and doxycycline); and carbapenem antibiotics (ertapenem, doripenem, imipenem / cilastatin, and meropenem).For example, in certain non-limiting embodiments, a microbial consortium can be administered with one or more antiviral agent selected from Abacavir, Acyclovir, Adefovir, Amprenavir, Atazanavir, Cidofovir, Darunavir, Delavirdine, Didanosine, Docosanol, Efavirenz, Elvitegravir, Emtricitabine, Enfuviltide, Etravirine, Famciclovir, Foscamet, Fomivirsen, Ganciclovir, Indinavir, Idoxuridine, Lamivudine, Lopinavir Maraviroc, MK-2048, Nelfinavir, Nevirapine, Penci cl ovir, Raltegravir, Rilpivirine, Ritonavir, Saquinavir, Stavudine, Tenofovir Trifluridine, Valaciclovir, Valganciclovir, Vidarabine, Ibacitabine, Amantadine, Oseltamivir, Rimantidine, Tipranavir, Zalcitabine, Zanamivir, and Zidovudine.In certain embodiments, a microbial consortium can be administered with one or more antifungal agent selected from miconazole, ketoconazole, clotrimazole, econazole, omoconazole, bifonazole, butoconazole, fenti conazole, isoconazole, oxiconazole, sertaconazole, sulconazole, and tioconazole; triazole antifungals such as fluconazole, itraconazole, isavuconazole,ravuconazole, posaconazole, voriconazok, terconazole, and albaconazole; thiazole antifungals such as abafungin; allylamine antifungals such as terbinafine, naftifine, and butenafine; and echinocandin antifungals such as anidulafungin, caspofungin, and micafungin; polygodial; benzoic acid; ciclopirox; tolnaftate; undecylenic acid; flucytosine or 5-fluorocytosine; griseofulvin; and haloprogin.In certain embodiments, a microbial consortium can be administered with one or more anti-inflammatory and / or immunosuppressive agent selected from cyclophosphamide, mycophenolate mofetil, corticosteroids, mesalazine, mesalamine, sulfasalazine, sulfasalazine derivatives, cyclosporin A, mercaptopurine, azathiopurine, prednisone, methotrexate, antihistamines, glucocorticoids, epinephrine, theophylline, cromolyn sodium, anti-leukotrienes, anticholinergics, monoclonal anti-IgE, immunomodulatory peptides, immunomodulatory small molecules, immunomodulatory cytokines, immunomodulatory antibodies, and vaccines.In certain embodiments, a Consortia can be administered with one or more prebiotic selected from, but not limited to, amino acids, biotin, fructooligosaccharides, galactooligosaccharides, inulin, lactulose, mannan oligosaccharides, oligofructose-enriched inulin, oligofructose, oligodextrose, tagatose, trans-galactooligosaccharide, and xylooligosaccharides.In certain embodiments, a Consortia described herein is administered in combination with an anti-inflammatory drug.In certain embodiments, a Consortia described herein is administered in combination with an anti-diarrheal drug.In certain embodiments, a Consortia described herein is administered in combination with a pain reliever. In certain embodiments, a Consortia described herein is administered in combination with a nonsteroidal anti-inflammatory drug (NSAIDs).In certain embodiments, a Consortia described herein is administered in combination with vitamins and supplements.In certain embodiments, a Consortia described herein is administered in combination with aminosalicylates.In certain embodiments, a Consortia described herein is administered in combination with antibiotics.In certain embodiments, a Consortia described herein is administered in combination with biologies. In certain embodiments, the biologies interrupt signals from the immune system that cause inflammation.In certain embodiments, a Consortia described herein is administered in combination with corticosteroids or steroids.In certain embodiments, a Consortia described herein is administered in combination with immunomodulators.In certain embodiments, the combination treatment of a Consortia comprises the pretreatment with antibiotics. In certain embodiments, the pretreatment of antibiotics.In certain embodiments, a bowel preparation (e.g., MiraLax) is administered in the late afternoon or early evening following the final dose of antibiotics.KitsThe presently disclosed subject matter provides kits for treating or preventing dysbiosis of the gastrointestinal tract. In certain embodiments, the dysbiosis is caused by or causes IBD, colitis, ulcerative colitis, and / or Crohn’s disease. In certain embodiments, the kit comprises an effective amount of presently disclosed Consortia or a pharmaceutical composition comprising thereof.In certain embodiments, the kit comprises an effective amount of FB-001 or a pharmaceutical composition comprising thereof. In certain embodiments, the kit comprises an effective amount of a functionally equivalent Consortia to FB-001 or a pharmaceutical composition comprising thereof. In certain embodiments, the kit comprises an effective amount of a functionally identical Consortia to FB-001 or a pharmaceutical composition comprising thereof.In certain embodiments, the kit comprises an effective amount of FB-003 or a pharmaceutical composition comprising thereof. In certain embodiments, the kit comprises an effective amount of a functionally equivalent Consortia to FB-003 or a pharmaceutical composition comprising thereof. In certain embodiments, the kit comprises an effective amount of a functionally identical Consortia to FB-003 or a pharmaceutical composition comprising thereof.In certain embodiments, the kit comprises a sterile container; such containers can be boxes, ampules, bottles, vials, tubes, bags, pouches, blister-packs, or other suitable container forms known in the art. Such containers can be made of plastic, glass, laminated paper, metal foil, or other materials suitable for holding medicaments. In certain non-limiting embodiments, the kit includes anaerobic containers to hold the Consortia(s) described herein. In certain non-limiting embodiments, the kit includes blister packs to hold the Consortia(s) described herein in the presence of no or limited amounts of oxygen. In certain non-limiting embodiments, the kit includes blister packs with desiccant to hold the Consortia(s) described herein in the presence of no or limited amounts of oxygen. In certain non-limiting embodiments, the kit includes bottles with desiccant to hold the Consortia(s) described herein in the presence of no or limited amounts of oxygen.In certain embodiments, the kits include instructions for administering the Consortia as described herein. In certain embodiments, the instructions include directions for administering the loading and the maintenance dose.In certain embodiments, the kits include storage instructions. In certain embodiments, the storage instructions are for storage at approximately -20°C. In certain embodiments, the storage instructions are for storage at less than -5°C. In certain embodiments, the storage instructions are for storage at less than approximately -15 to -20°C, -10 to -20°C, -10 to -15°C, -5 to -10°C, 0 to - 5°C, below 0°C, or 0 to -20°C. In certain embodiments, the storage instructions are for storage at less than approximately 4°C. In certain embodiments, the storage instructions are for storage at room temperature.In certain embodiments, the kits include instructions for maintaining the Consortia in no or low oxygen conditions.In certain embodiments, the kits include instructions for the subject to remain off all antibiotics during treatment with the Consortia.In certain embodiments, the kit includes FB-001 and instructions for administering FB- 001.In certain embodiments, the kit includes FB-003 and instructions for administering FB- 003.EXAMPLESExample 1: Design of ConsortiaWhile microbial consortia of two or more microbial strains have been made before, limitations existed that prevent manufacturing and clinical efficacy. Specifically, manufacturing limitations have prevented the design and generation of large consortia that are able to engraft in the gastrointestinal tract and build a functional microbiota system.Isolation of donor-derived microbial strains. Microbial strains were isolated and identified using the methods described in PCT / US2021 / 021790.Generation of Consortia. Using the microbial strains identified using the isolation and identification methods described in PCT / US2021 / 021790, over 30 large consortia were made and examined for their functional ability to metabolize oxalate, absence of phages, acceptable endotoxin levels, and their ability to be manufactured in multi-strain drug substances. The reason for the large number of experimental large consortia was because it was unknown what combination of microbial strains would be necessary given the considerations above. More so, the combination of microbial strains could not be predicted with algorithms and required wet laboratory work to determine efficacy and manufacturability.Nineteen exemplary consortia are provided in Consortia I-XIX.While Consortia V was most effective at oxalate metabolism and degradation (i.e., Consortia V had the lowest concentration of urinary oxalate), additional investigation and modification of the Consortia was needed to design a product for the treatment of disease, specifically a disease that causes or is caused by decrease ability or inability to effectively metabolize and degrade oxalate in the gastrointestinal tract. Accordingly, modifications of Consortia V were made to determine which microbiota provided functional benefits, including but not limited consortia growth, oxalate metabolism and degradation, consortia engraftment, and consortia survival, and which microbiota were either not needed or provided a detriment to the patient receiving the consortia as treatment of the disease or a detriment to the function of the consortia as a whole (including but not limited consortia growth, oxalate metabolism and degradation, consortia engraftment, and consortia survival). Examples of such designed and investigated consortia are Consortia IX-XVI.Of Consortia IX-XVI that were designed and tested, Consortia IX was selected as the lead for clinical development. Key changes made as variations of the consortia were made to modify for the treatment of disease, specifically a disease that causes or is caused by decrease ability or inability to effectively metabolize and degrade oxalate in the gastrointestinal tract, include removing the Citrobacter freundii strain because through experimentation it was determined to be facultative anaerobes (see e.g., strain removal between Consortia XIII and XV and between Consortia XXIV and XIII and XII), replacement of one Bacteroides kribbi species with a different Bacteroides kribbi species cluster (see e.g., strain replacements between Consortia XV and XVI), replacement of one Blautia faecis species with a different Blautia faecis species (see e g., strain replacements between Consortia XV and XVI), strains that were determined to be duplicative strains based on Whole Genome Sequencing cluster (see e.g., strain removals between Consortia XVII and XVI), replacement of one Bifidobacterium adolescentis with an alternate Bifidobacterium adolescentis to improve growth in culture (see e g., strain replacement between Consortia X and XII), replacement of one Bifidobacterium pseudocatenulatum with an alternate Bifidobacterium pseudoactenulatum to improve growth in culture (see e.g., strain replacement between Consortia X and XII), replacement of one Bacteroides xylanisolvens with an alternate Bacteroides xylanisolvens to improve growth in culture (see e.g., strain replacement between Consortia X and XII), replacement of one Clostridium citroniae with an alternate Clostridium citroniae to improve growth in culture (see e.g., strain replacement between Consortia X and XII), replacement of one Blautia faecis with an alternate Blautia faecis in order to identify a Blautia strain that was able to grow sufficiently to produce a master cell bank (see e.g., strain replacement between Consortia X and XII), removal of Holdemanella biformis to eliminate phage risk becausewhile a phage was not detected in co-culture it was detected using bioinformatic methods (see e.g., strain replacement between Consortia X and XII), and removal of Faecalibacterium prasnitzii to eliminate phage risk because while a phage was not detected in co-culture it was detected using bioinformatic methods (see e.g., strain replacement between Consortia X and XII).Example 2: Drug Product Design and ManufactureAs shown in Example 1, the Consortia described herein were designed to be a complex community of anaerobic microbiota that can engraft and function in a gastrointestinal tract. However, prior methods known to one of skill in the art were not capable of manufacturing such large consortia. Accordingly, new methods of manufacture were needed in order to grow the microbiota in discrete groups (i.e., drug substances) to then form a final drug product.Conventionally, Live Biotherapeutic Products (LBPs) are manufactured one strain at a time (i.e., single strain manufacturing). Single strain manufacture necessitates fermentation scale- up of each single strain followed by lyophilization to make individual drug substances (each a “DS”). Thereafter the multiple DSs of individual lyophilized stains are then blended into a mixture and filled into capsules or other suitable packaging / filling to make a final drug product (a “DP”). While this works for small consortia, it is not feasible to grow 100+ strains separately, make 100+ DSs, and then blend 100+ DSs into a stable DP. In addition to stability limitations, current technology would require 1 or more year(s) to manufacture a single DP. Accordingly, conventional manufacturing using current technology was not an option for a DP comprising 100+ strains, and preferably 145+ strains as provided in Consortia IX.As the Consortia were designed and modified as described in Examples 1 and 2, manufacturing methods were developed that were capable of manufacturing the 145+ strain consortia that comprise over 90 species, and 4 or more or the 6 taxonomic phyla found in the human gastrointestinal tract microbiome. More so, methods were developed to modify for Consortia IX that comprises approximately 99 species across the taxonomic phyla of Bacteroidetes, Firmicutes, Actinobacteria, Proteobacteria, and Archaea. The methods developed and described herein are mixed co-culture methods that are capable of stably growing greater than 50 strains in one co-culture to generate DSs with greater than 50 strains.Strains were selected for co-culture by based on growth rates and the manufacturing was initially designed to add strains to the co-culture at different times throughout the manufacturing process in order to achieve growth of each strain. This approach was termed “time of addition” manufacturing. The rationale behind this initial approach was to ensure the strains reanimate in the gastrointestinal tract to increase efficacy of engraftment (i.e., allow for engraftment before the strains are excreted. Reanimation and engraftment of the lyophilized strains require preserving the strains in an “active state” (i.e., active growth state). However, this “time of addition”manufacturing approach was not successful because growth rates of the strains in the Consortia described herein are highly variable which makes it difficult to achieve exponential growth simultaneously for diverse strains in coculture. Accordingly, it was determined that additional experimentation was needed in order to understand each strain’s unique growth kinetics to enable binning of strains based on growth rate and further modification of time of addition to the bioreactor. Growth kinetic assays were performed using HTP anaerobic growth kinetic assays on each individual strain in each of Consortia IX-XVI at 8 different inoculation densities.While experimentation to understand each strain’s unique growth kinetics proved helpful with the time of addition manufacturing, ultimately the highly variable nature of growing strains from a lyophilized powder to an active consortia in a bioreactor proved undesirable for the time of addition methods.Accordingly, a second approach for coculture was developed. Instead of applying different time of additions, the second approach used inoculation density adjustment for each strain to synchronize growth and control of strain distribution at the time of harvest from the coculture (“inoculation density” manufacturing). Using the unique growth kinetics determined for each strain in the Consortia, specifically Consortia IX-XVI, growth zones were determined for each strain. In doing so, it was determined that coculture was effective and possible if each strain was added to culture at an initial time point based on inoculum density (i.e., number of cells per strain added to the co-culture) such that higher inoculum densities of certain strains resulted in shorter growth lag time for such strains. Based on this, higher inoculum density of slow growing strains and lower inoculum density of fast growing strains resulted in a synchronized harvest time. As shown by means of example in Figures 1A and IB, modifying inoculation densities of individual strains allowed control over the strain distribution and improved strain recovery in cocultures (i.e., even distribution of strains as well as higher number of strain recovery are achieved by adjusting inoculum densities). Figure 1A shows an example of a co-culture of 21 fast growing strains where only 4 of the 21 strains were undetectable by metagenomics in the final product. However, it is important to note that even if a strain is not detected in the final product, the strain may still provide a community advantage to allow for more efficient and robust growth of other strains that are detectable in the final product. Figure IB shows a further modified experiment of that show in Figure 1A where the time of harvest and strain detection was modified. As shown the different timing of growth and culture led to a better distribution of strains and detection of all 21 strains.Further modification of the coculture process was needed to improve fermentation. For example, additional modification was performed to control for pH and to achieve conditions of growth based on the bioreactor container (i.e., the type of container and the size of the container).Using the methods developed and described herein, Consortia IX-XVI were each manufactured using only 7 DSs. One exemplary 7 DS Drug Product comprises: 3 O. formigenes monocultures , the strains of DS1 (e g., listed in Table 1), the strains of DS2 (e.g., listed in Table 1), the strains of DS3 (e.g., listed in Table 1), the strains of DS4 (e.g., listed in Table 1).Using the methods developed and described herein, the microbes listed in Table 2 (FB- 003 or FB-003 Consortia) was manufactured using only 4 DSs. One exemplary 4 DS Drug Product comprises: the strains of DS1 (e.g., listed in Table 1), the strains of DS2 (e.g., listed in Table 1), the strains of DS3 (e.g., listed in Table 1), the strains of DS4 (e.g., listed in Table 1).In order to identify each DS without sequencing the entire genome of all strains and in order to ensure proper growth throughout the coculture process, identifier strains were developed. For DS1, the identifier strains were Bacteroides thetaiotaomicron, Bifidobacterium pseudocatenulatum, and Megasphaera massiliensis. For DS2, the identifier strains were Bacteroides ovatus, Faecalibacterium prausnitzii, and Phascolarctobacterium faecium. For DS3, the identifier strains were Blautia wexlerae, Anaerostipes hadrus, and Clostridium bolteae. For DS4, the identifier strains were Holdemanella biformis, Parasutterella excrementihominis, and Dialister invisus.As described herein, the number of strains detected at the conclusion of the co-culture may be less than the number of strains added at the beginning of the culture. This may be a result of limited detection methods. Furthermore, while not all strains may be detected at the conclusion of the coculture process, the inclusion of the undetected strains may still be vital for the survival and propagation of other strains that are detected.In one experiment, DS1 consisted of 54 initial strains and 50 strains were detected at the end of the coculture process; DS2 consisted of 47 initial strains and 39 strains were detected at the end of the coculture process; DS3 consisted of 33 initial strains and 30 strains were detected at the end of the coculture process; and DS4 consisted of 14 initial strains and 11 strains were detected at the end of the coculture process.This achievement of the detection of strains was achieved through development of a fermentation process that allowed for growth of diverse strains in coculture. Variables that were investigated include growth kinetics of each strain, nutritional requirements for each strain, competition for nutritional sources in each D S, selection of the starting inoculum concentration to achieve strain growth and distribution in each DS. For example growth curves were performed and used to define DS buckets as well as starting inoculum composition. This is shown in Figures 2A and 2B. Figure 2A shows the design of strain segregation into 4 DS buckets based on slow and fast growing strains. Figure 2B shows the starting inoculum seed design for fast and very fast growing strains. Using 5 iterations of the strain segregation and inoculum seed designmethods, the DS1, for example, was able to increase its yield rate from approximately 35 / 54 strains detected at the conclusion of the coculture process to 50 / 54 strains detected at the conclusion of the coculture process.Additional experimentation was required to successfully manufacture the DSs at large scale. For example, experimentation was performed on sterilization procedures and raw materials used in the media, gas solubility in the bioreactor (i.e., fermenter), shear stress caused by the impeller and gas sparging in the bioreactor, and mass transfer and mixing times. Each of these factors are necessary in order develop a process that could successfully produce a complex consortia such as any of the Consortia described herein. For example, through experimentation, it was determined that nitrogen sparging lead to higher sheering and impacted gas solubility. Accordingly, experiments were performed to adjust the speed of the sparger, location of the sparger, and replacement of sparging to gas overlay. The data showed that gas overlay was the only approach that provided successful coculture of DSs. For example, data from different sparging conditions only allowed for the detection of up to 36 out of 54 strains from DS1 while gas overlay allowed for detection of an additional 11 species at the conclusion of the coculture (i.e., 47 / 54 strains).The next step in the manufacturing process that had to be developed was a method of storing the final product in a way that preserved the stability and activity of the strains. Freezing and lyophilization methods were investigated to determine what would preserve the activity and viability of the strains for each DS.In order to determine if lyophilization would be better than freezing to preserve the activity and viability of the strains in each DS, lyophilization processes had to be developed because none were known in the art for the complexity of the DSs and Consortia provided herein. Key variables that were investigated in order to develop lyophilization process for each DS included but were not limited to: formulation of the broth or alternative microbiota suspension media, methods to prevent oxygen contamination during the lyophilization process, excipient:broth ratio, parameters for freezing the microbiota suspension prior to the lyophilization, cycle parameters for the lyophilization, sterilization requirements, methods for reviving the microbiota following lyophilized storage, buffers for reviving the microbiota, and storage of the lyophilized DS.By means of example, high throughput, foil covered plates were used as one of the test options for storage of the lyophilized DS. This was presumed to work because the foil cover should prevent oxygen exposure. However, it was determined that foil covered plates in fact did not prevent oxygen contamination because there was no way to partially stopper the plate. Another storage method that was investigated was glass and plastic tray vials with multiplexed stoppers. The theoretical advantage of this approach was hypothesized to be the ability to do highthroughput screening without the need to individually stopper each vial because the multiplexed stoppers can be pushed into the vials in a single step. However, this method proved ineffective because oxygen contamination occurred with the removal of the multiplexed stoppers. After exploring additional options for methods of preserving the lyophilized product, it was determined that individual glass vials with individual stoppers allowed for long term storage without oxygen contamination.By means of a second example, it was necessary to determine the correct formulation for the lyophilization buffer / media. The following lyoprotectants were investigated to determine the correct formulation for each DS: sorbitol, maltodextrin, OPS diagnostics buffer, sucrose, inulin, alginate, mannitol, trehalose, and skim milk. For example, Figure 3A shows examples of different viabilities of DS2 based on different lyoprotectants and Figure 3B shows examples of different viabilities of DS1 based on different lyoprotectants. The addition of reducing agents including but not limited to cysteine HCL and riboflavin were also investigated as shown in Figure 4A (DS2) and Figure 4B (DS1). Additional lyophilization formulations that were tested include 8% Maltodextrin+ 0.5% Inulin + RA, 5% Sucrose + 10% Glycerol + 0.3% Inulin + RA, 7% Trehalose+8% Maltodextrin+RA, 3% Sucrose+5% Maltodextrin + 0.5% Inulin + RA, 5% Maltodextrin+OPS Diag+ 0.5% Inulin + RA, and 5% maltodextrin+10% Glycerol+0.3% Inulin+RA.Based on freeze thaw and lyophilization experiments, data suggested that 10-12% solids was the selected dose. However, additional experiments were performed to determine if a lower dose would be possible. One exemplary experiment on DS2 is shown in Figure 5A and a second exemplary experiment is shown in Figure 5B.Assays were then performed to determine the success rates of cell revival. Cell revival was done using the Anaerobe systems YCFAC media and dilution schemes were conducted using 100 fold dilution to the lyophilized powder (e.g., 50 mg (0.05 g) of powder was diluted in 5.0 mL of YCFAC media). Revival was then detected using flow cytometry and the Coulter Counter.The experiments performed herein and the data generated determined that lyophilized material produced comparable colonization of strains in mice.Example 3: Synthetic ConsortiaIsolation and Processing. Isolation of bacterial strains to create synthetic consortia: bacterial strains to create consortia were isolated from healthy human stool samples collected under anaerobic conditions, homogenized, and then bacterial species from each sample were identified using whole-genome sequencing (WGS). From there, the bacterial strains and abundance thereof were identified.Stool samples were then processed and bacterial strains isolated for culture on appropriate culture media (e.g. BHI, blood agar). Isolation of oxalate degrades and strains specific to metabolize EH-related pathways were prioritized along with fastidious and unique strains and strains associated with a healthy gut microbiome. Following culture, strains were purified and sequenced using metagenomics. From the cultured, isolated strains, communities to treat enteric hyperoxaluria were created based on the notion of our bacteria to fill critical functional niches in the gut, support normal GI physiology, support engraftment of specialty strains such as O. formigenes, and degrade oxalate.Diversity of synthetic consortia: each Consortium described herein contains unique species and strains to cover various metabolic phenotypes (e g. bile acid metabolism, short chain fatty acid synthesis, oxalate degradation). A core set of 31 bacterial strains were similar between synthetic consortia and each community had its unique signature as indicated in the Venn diagram. The number of species present in each consortium created ranged from 40 to 103 species and the number of strains ranged from 75 to 195 as shown Figures 6A and 6B. The species and strains comprised varying proportions of the phylum-level diversity where the Bacteroidetes to firmicutes ratio ranges from 51% to 96% indicating that the general composition varied.Example 4: The Manufacture of Threonine Auxotrophic MicroorganismsCertain microorganisms are auxotrophs. This means that the microorganism is not able to synthesize a particular organic compound required for its growth. One such organic compound that certain microorganisms are incapable of synthesizing themselves is threonine. Furthermore, while some microoganisms are not per se auxotrophs of threonine, they are inefficient producers of threonine which prevent effective growth in commonly used growth medias.N-Acetylgalactosamine (GalNAc) is an amino sugar derivative of galactose that is typically the first monosaccharide that connects serine or threonine in particular forms of protein O-glycosylation. While it is possible to supplement certain small batch growth medias with GalNAc to grow threonine auxotrophs without the addition of threonine, such supplementation is not preferred for large batch manufacture because GalNAc is costly and large amounts are needed for effective growth of microorganisms that require such galactose derivative. Furthermore, certain medias such as YCFAC media is incapable of effectively growing certain threonine auxotrophs even in the presence of GalNAc.Accordingly, a method of improving the expansion and growth of inefficient producers of threonine is needed to effectively grow such microorganisms.One such microorganism included in the consortia described herein is Akkermansia muciniphilia. Akkermansia is not capable of synthesizing threonine itself and thus is not able to effectively expand and grow in culture that is lacking a GalNAc source (or a primary source thatcan be metabolized into GalNAc). Furthermore, GalNAc is the preferred carbon source for Akkermansia and thus known methods of effectively growing and manufacturing Akkermansia comprise the addition of GalNAc to the growth media.Accordingly, experiments were designed to identify novel methods of growing Akkermansia in large batches without large amounts of GalNAc. Specifically, three different growth medias were tested: YCFAC + GalNAc, YCFAC + GalNAc + Threonine, and YCFAC + Threonine. Since BHI is an animal-based media that contains threonine, BHI media was used as a positive control (specifically BHI media + GalNAc + Hemin + VitaminK). Because GalNAc is the preferred carbon source for Akkermansia, it was expected to be needed in all medias in order to allow expansion and growth of the microorganism; however, the expected question was how much GalNAc is needed, not whether GalNAc was needed at all, if threonine is also added. Surprisingly, it was determined that 1) YCFAC + 0.5g / L GalNAc did not support Akkermansia growth, 2) YCFAC + 0.5g / L GalNAc + lOmM threonine did support growth, and that 3) YCFAC + lOmM threonine alone supports the growth of Akkermansia. In these experiments, a seed culture containing 0.5g / L GalNAc in YCFAC was used to initiate cell growth before being transferred to large fermenter for growth and expansion with the 3 medias described above.However, certain of the consortia described herein comprise more than 100 different microorganisms, Akkermansia being only one of the more than 100 different microorganisms. Furthermore, the manufacturing methods described herein allow for the growth and manufacturing of multiple microorganisms in a single large batch culture (e.g., in a fermenter). The question then became how to grow Akkermansia in a large co-culture when it is the only microorganism that is a threonine auxotroph that has a preferred carbon source of GalNAc. Accordingly, an experiment was designed to determine if it was possible to start a seed culture with Akkermansia alone and then combine it with a second seed culture of multiple microorganisms for the large batch expansion.This experiment comprised : 1) a seed culture was first grown to allow the Akkermansia to begin growing in a small culture (i.e., a seed culture) of lOmL before expansion into a large batch fermenter, 2) concurrently with the Akkermansia seed culture, a second lOOmL seed culture of all other microorganism in the drug substance was separately grown, 3) the lOOmL seed coculture and the lOmL Akkermansia seed culture were combined into a large batch fermenter (e.g., IL or more), and 4) the strains of the drug substance were detected and the ability of Akkermansia to grow and expand in the co-culture was assessed. A diagram of this experiment is shown in Figure 7A.As shown in Figure 8, it was surprising to see that Akkermansia was unable to grow in YCFAC media that was supplemented with GalNAc, Hemin, and VitaminK (0.0000%Akkermansia detected) compared to BHI media that was supplemented with GalNAc, Hemin, and VitaminK. Accordingly, it was determined that YCFAC + GalNAc cannot support the growth of Akkermansia. The question then became whether the addition of threonine could recover the growth of the Akkermansia.The next question was whether GalNAc was needed for if threonine was added. Specifically, the question was how Akkermansia would grow in YCFAC + lOmM threonine (72hr growth) compared to a media comprising YCFAC + lOmM threonine + 0.5 g / L GalNAc (48hr growth). It was surprising to find that the results showed comparable growth with and without the GalNAc (an OD of 0.25 for w / o GalNAc and an OD of 0.35 for w / GalNAc).A co-culture experiment similar to that described above and shown in Figure 7A was designed to evaluate the need for GalNAc and threonine. In this experiment, two seed cultures were used: 1) Akkermansia seed grown in YCFAC + lOmM threonine + 0.5 g / L GalNAc, and 2) the other microorganisms in the drug substance (14 microorganisms) grown in YCFAC alone. The seed cultures were then combined into a large batch fermenter comprising YCFAC + lOmM threonine (i.e., no GalNAc). See Figure 7B. This study showed that no GalNAc was needed in the presence of lOmM threonine in a large batch fermenter in order for Akkermansia to grow in a co-culture with other microorganisms that are not threonine auxotrophs. Furthermore, in the lOmM threonine YCFAC media, Akkermansia was detected at all growth time points (Figure 13)Additional experiments further showed that GalNAc was not even needed in the seed culture in order to achieve Akkermansia growth.The ability to grow Akkermansia without GalNAc was very surprising given that GalNAc is Akkermansia’ s preferred carbon source. Furthermore, the ability to grow Akkermansia in a media without GalNAc provides a means of making microbial drug products comprising GalNAc wherein the Akkermansia is grown in a co-culture of multiple microbes.Example 5: Clinical Candidate SelectionConsortia IX was selected as the clinical candidate for clinical trials for the treatment of enteric hyperoxaluria and was termed FB-001. FB-003 was selected as the clinical trial candidate for clinical trials for the treatment of IBD, ulcerative colitis, Crohn’s disease, and other associated dysbiotic diseases and conditions. FB-001 comprises 148 different anaerobic microbial strains and FB-003 comprises 145 different anaerobic microbial strains. Both FB-001 and FB-003 were designed to emulate the metabolic and phylogenetic diversity of a healthy, human microbiome (Figure 13) and was split into 7 (for FB-001) and 4 (for FB-003) different drug substances for manufacturing purposes. Tables 1 and 2 show the different drug substances. Species were identified by 16S rRNA gene sequencing and whole genome sequencing of RCBs. The species inthe consortium span six of the major phyla found in the GI tracts of healthy adults (King, Desai et al. 2019) with the deliberate exception of Fusobacteria, a phylum generally associated with human infections and enriched for opportunistic pathogens. The strains of both FB-001 and FB-003 encompass 10 distinct classes, 18 orders, 26 families, and 59 genera.Prior to lyophilization, the cell pellet containing the FB-001 or FB-003 microbial strains were resuspended in YCFAC media with lyoprotectants and then lyophilized. The YCFAC media and lyoprotectants were chosen to stabilize the DS during the lyophilization step. The lyoprotectant combination of 8% maltodextrin + 0.5% inulin was chosen for the final DS formulation as it demonstrated high viability of the FB-001 and FB-003 microbial strains in formulation development studies.Maltodextrin was also added as a filler during DP manufacturing.The capsules to encapsulate the DP were enteric coated and were chosen to release the DP in the small intestine and resist the gastric acids as they pass through the gastrointestinal tract. The dissolution of these capsules was tested per USP <701> at a pH of 1.2 and showed no disintegration for 2 hours. At a pH of 6.8, the capsules fully disintegrated within 30 minutes, which is the target release pH in the GI tract for FB-001 and FB-003 DP (Hydroxypropyl methylcellulose [HPMC] Capsule COA).Function Properties of FB-001 and FB-003. FB-001 and FB-003 were manufactured using 7 or 4, respectively, individual drug substances (DS) that contain a total of 148 and 145, respectively, anaerobic microbial strains and is enriched for species performing beneficial or normalizing functions in the human GI tract.For FB-001, the first of these beneficial or normalizing functions is oxalate degradation, which is the primary EH disease modifying mechanism of FB-001. Oxalobacter formigenes is the principal driver of oxalate degradation in the human GI tract. O. formigenes uses oxalate as its exclusive energy source, metabolizing significant concentrations of oxalate for energy generation and biomass production. The metabolism of oxalate is mediated by a series of enzymatic and transport reactions that ultimately consume oxalate and release CO2 and formate.Formate, as a by-product of oxalate metabolism, can ultimately inhibit further oxalate metabolism in vitro if it is not removed. Therefore, FB-001 also contains strains capable of formate degradation. These formate-utilizing bacteria help to clear the potentially inhibitory metabolic byproducts of oxalate metabolism.FB-001 and FB-003 also contain strains that are oxalate resistant, able to grow in the presence of oxalate concentrations that are over a magnitude or higher than the physiologically normal concentrations of oxalate. This enrichment of oxalate-tolerant strains in the FB-001 and FB-003 consortium may support stable engraftment despite potentially elevated levels of freeoxalate in the GI lumen of patients with EH, as the abundance of the key oxalotrophs will naturally increase with spikes in oxalate concentration.The FB-001 and FB-003 Consortia were specifically designed to contain phylogenetically diverse microbial species that function mutualistically to improve the dysbiosis associated with malabsorption. This was achieved by the inclusion of numerous species intended to support the community by restoring essential metabolic functions. The strains that make up the FB-001 and FB-003 Consortia were selected based on their predicted ability to perform a variety of supportive metabolic functions that would contribute to engraftment regardless of differences in patient physiology or diet. Metabolism of macronutrients and dietary molecules that are not digested or utilized by host cells may result in the release of metabolic products that feed other members of the microbiome community.Other strains in FB-001 and FB-003 were evaluated for unique and potentially beneficial biological functions in the GI tract, including production of short-chain fatty acids (SCFAs), crossfeeding activity, and mucin degradation. SCFAs are absorbed by the host and have been recognized to confer a range of health-promoting functions by acting as key energy substrates for colonocytes, enterocytes, and hepatocytes, while also acting as signaling molecules recognized by specific G-protein couple receptors targeting primarily enteroendocrine and immune cells in the lamina propria of the intestinal mucosa. Strains in FB-001 and FB-003 were evaluated for their cross-feeding activity, a process in which bacteria make by-products that feed other bacteria. Cross-feeding stabilizes the gut microbiome and creates novels niches. Strains in FB-001 and FB- 003 were also evaluated for putative protective and / or anti-inflammatory properties.Table 3 summarizes the number of strains in FB-001 that contribute to each of these functional properties, and characteristics that are associated with each FB-001 species are summarized in Table 4.Table 3. Function Properties of FB-001 and FB-003 DPsTable 4. Species Included in FB-001 and FB-003 Drug Products and Characteristics*not included in FB-003Formate Metabolism. The FB-001 and FB-003 DP consortium contain formate-utilizing bacteria to maintain maximal carbon flux through the pathway. Symbiotic bacterial species such as methanogens found in the human GI tract can efficiently remove formate via reduction to methane in the presence of hydrogen gas produced by microbial fermenters. Therefore, the FB- 001 and FB-003 Consortia includes Methanobrevibacter smithii (DS-CoC2), the most prevalent and abundant archaeal methanogen in the gut, and one that efficiently metabolizes formate, as well as the acetogenic gut commensal Blautia hydrogenotrophica (DS-CoCl), which utilizes formate to generate acetate for short-chain fatty acid (SCFA) synthesis, and a panel of anaerobes (eg, Sutterella and Parasutterelkp found in DS-CoC2 and DS-CoC4) that express cytochromedependent formate dehydrogenases that oxidize formate to CO2.Supportive Metabolic Functions. FB-001 and FB-003 also contain a diverse panel of broadly functional commensals that fulfill unique and potentially beneficial biological functionsin the GI tract, including metabolism of macro-nutrients, production of short-chain fatty acids, cross-feeding activity, and mucin degradation.Composition of FB-001 and FB-003 DPs. FB-001 DP is a highly complex, mixed fermentation of 148 microbial strains, chosen for their potential role in supporting a healthy GI tract. Similarly, FB-003 DP is a highly complex, mixed fermentation of 145 microbial strains, chosen for their potential role in supporting a healthy GI tract.To support clinical studies, FB-001 DP was characterized for relative abundance of individual species in the final DP using metagenomic sequencing, as well as for total O. formigenes content. In metagenomic sequencing and analysis, strains were first confirmed to be present in the sample by positive identification of pre-specified biomarkers (short sequences of DNA) that are unique to the strain of interest. Then, the results of metagenomic sequencing were reported as the relative abundance of each strain, which approximates the percentage of genome copies that belong to each strain and can range from 0 to 100%. The relative abundance was then calculated by comparing the number and frequency of detected biomarkers to the total number of strain-specific biomarkers and the number of sequencing reads. The percent contribution of each strain in the FB-001 DP comprises a predominant portion of the three (). formigenes strains identified by 16S RNA and carbon source analysis described below as follows: approximately 32% O. formigenes on a relative abundance basis (i.e., approximately 40% on a viable cell count basis) with the other 145 strains having relative abundance values ranging from 18% to 0.015% (distribution of a typical human microbiome).FB-001 DP was manufactured as a single batch. A single capsule of DP from was collected and stored at -20°C ± 5 until DNA extraction. FB-001 DP was sequenced via shotgun metagenomics and the metagenomic sequences of DP were analyzed to determine the composition of FB-001 DP. Results were reported as the relative abundance of each strain. Relative abundance approximates the percentage of FB-001 DP genome copies that belong to each strain and can range from 0 to 100%. A total of 60 of 148 strains were detected at or above their qualified limit of detection, including 21 strains from DS-CoCl, 13 strains from DS-CoC2, 16 strains from DS-CoC3, 7 strains from DS-CoC4, and each of DS- OF1, DS-OF2, and DS-OF3. The absence of detection of a strain should not be interpreted as its absence from the drug substance. The 60 detected strains account for 95.932% of the biomarkers detected in FB-001 DP. The remaining 88 strains therefore account for 4.068% of the biomarkers. The relative abundance profile is expected to vary between batches and data will continue to be collected during development to understand the magnitude of the variability. Furthermore, the exact percentages should not be interpreted as limiting or exclusive; rather each batch of DP may vary in its microbial distribution based onnatural growth of bacterial in co-cultures. An example of the relative abundance profile of the microbes in one lot of FB-001 is provided in Table 5.Table 5. Relative Abundance Profile of a FB-001 DP LotProcess Development. The blending process during DP manufacture for FB-001 and FB- 003 was developed to create a homogenous mixture of the DSs. During the development phase, the blend-sieve-blend technique for mixing the DSs was tested. Using this technique, several of the DSs were blended in a Turbula mixer for 15 minutes at 43 rpm followed by sieving of the material through #50 sieve. The material was again blended for 15 minutes at 43 rpm. An aliquot of blended material from the top, middle and bottom of the container were taken and evaluated for TCC, VCC and strain distribution by relative abundance. The blending study results showed that the DS material was homogenously mixed with blend-sieve-blend mixing technique. For the FB- 001 DP, the VCC / g, TCC / g and relative abundance of the three O. formigenes strains in the top, middle and bottom of the mixing container are very similar, which indicates a homogenous blend of DSs in the blending container.A diagram of the coculture method of manufacture is provided in Figure 10.Manufacture of DS1. Yeast casitone fatty acids with carbohydrates (YCFAC) medium, pH 7, was prepared at IX concentration in batches of 4 L each for Seed 1 fermentation and Seed 2 fermentation. The medium was prepared by adding the components indicated in Table6 to 3.46 kg of water for injection, boiling for 5 to 10 minutes, then allowing the medium to cool down. Upon reaching a temperature of 50°C or lower, the medium was sparged with N2 while the rest of the components were added in the following order: sodium bicarbonate, 50X volatile fatty acid solution, L-cysteine HC1 monohydrate, 0.5% hemin solution, and 25X vitamin solution. The pH was adjusted to 7 with 10 NNaOH or sulfuric acid, and the medium was autoclaved at 122.5°C for 45 minutes. The medium was incubated at 37°C for a minimum of 24 hours prior to inoculation for a contamination check.Table 6. YCFAC MediaA 5X concentration media was also made for use in the main fermentation. The 5X stock was made using the same proportions as described in Table 6, scaled up to 5X. The 5X media was diluted to a IX concentration before the main fermentation process.Resuspension medium was also made and comprised YCFAC medium with reducing agents L-cysteine HC1 and riboflavin, pH 7. To prepare resuspension medium, 0.6 g of riboflavin and 2.0 g of cysteine-HCl are added per kg of YCFAC medium. The medium is stirred untilcompletely dissolved, then titrated with 10 NNaOH or sulfuric acid to obtain a final pH of 7. The medium is filtered with a 0.22 pm polyethersulfone (PES) filter. The final concentration of Riboflavin was 0.06% and the final concentration ofL-cysteine HCL was 0.2%, in YCFAC media.The volatile fatty acid solution (50X) for the YCFAC media was made and comprised Glacial acetic acid (65.7%w / w for the 50X concentration; 1.31%w / w for the IX concentration), Propionic acid (24.2%w / w for the 50X concentration; 0.48%w / w for the IX concentration), Isobutyric acid (3. l%w / w for the 50X concentration; 0.06%w / w for the IX concentration), n-Valeric acid (3.5%w / w for the 50X concentration; 0.07%w / w for the IX concentration), and Iso-valeric acid (3.5%w / w for the 50X concentration; 0.07%w / w for the IX concentration).The vitamin solution (25X) for the YCFAC media comprised Biotin powder (1.31 Quantity / 6kg WFI (g)), Folic acid (1.31 Quantity / 6kg WFI (g)), Pyridoxine hydrochloride (6.56 Quantity / 6kg WFI (g)), Thiamine-HCl-2H2O (3.28 Quantity / 6kg WFI (g)), Riboflavin (0.13 Quantity / 6kg WFI (g)), Nicotinic acid (3.28 Quantity / 6kg WFI (g)), D-calcium pantothenate (3.28 Quantity / 6kg WFI (g)), Vitamin B12 (0.07 Quantity / 6kg WFI (g)), 4-aminobenzoic acid (3.28 Quantity / 6kg WFI (g)), and DL-alfa-lipoic acid (3.28 Quantity / 6kg WFI (g)).Microbial strains intended for FB-001 and FB-003 DS-CoCl were isolated from stool samples obtained after extensive donor screening. An overview of the strain isolation and purification process, RCB banking, and RCB identity / purity testing is provided in Figures 11 and 12. The entire stool sample homogenization and aliquoting was carried out under anaerobic conditions, starting with transfer of the stool sample to the anaerobic chamber within 15 to 30 minutes of the collection, followed by homogenization and addition of a 1 : 1 solution of PBS and 50% glycerol prior to aliquoting into 6 to 9 separate cryovials and transferring to < -65°C for storage until further processing.To isolate individual strains, fecal samples were serially diluted and then plated onto a variety of agar plates containing anaerobic microbial cultivation media (counted as passage 1). The plates were incubated at 37°C under anaerobic conditions. Single colonies from these initial growth plates were picked for further isolation on appropriate microbial cultivation agar media plates (counted as passage 2). After incubation at 37°C, if the single-colony plating resulted in isolated colonies with uniform morphology, the culture was further characterized for strain identification. Preliminary strain identification was performed either by 16S rRNA gene sequencing or by creating and analyzing proteomic fingerprinting using high-throughput matrix- assisted laser desorption / ionization-time of flight spectrometry. If the single-colony plating resulted in multiple colony morphologies, each unique colony type was picked from this plating for further isolation on an appropriate cultivation agar plate until uniform colony morphology wasachieved (counted as passage 3 ormore). The passage history of each strain in FB-001 andFB-003 DS-CoC 1 and the agar and broth medias are listed in Table 7.Table 7. Isolation of Research Cell Banks Used in FB-001 and FB-003 DS-CoClAbbreviations: FBI = Federation Bio isolate; RCA = reinforced clostridial agar; RCB = research cell bank; YCFAC = yeast casitone fatty acids with carbohydratesTo bank the RCBs used in FB-001 and FB-003 DS-CoCl, monocultures were inoculated into culture tubes containing appropriate broth media and incubated under anaerobic conditions at 37°C until sufficient growth was observed. Sterile glycerol solution was added to achieve a final glycerol concentration of 25% prior to aliquoting approximately 0.2 mL into 2D-barcoded cryo-vials. After removing the cryovials from the anaerobic gas chambers, the 2D bar codes at the bottom of the vials were scanned promptly and the vials were transferred to < -65°C as the final step in the banking of the RCBs.After at least 10 hours of freezing, one vial of each purified frozen RCB was retrieved from the freezer and thawed under anaerobic conditions followed by plating on agar plates containing appropriate growth media. The plates were incubated under anaerobic conditions at 37°C. Growth on the plate was observed to confirm revival and uniform colony morphology for each purified isolate. Following confirmation of uniform colony morphology for each RCB,individual colonies were analyzed by 16S rRNA gene sequencing (see Sequence Listing). RCBs were further characterized using whole-genome sequencing followed by genome assembly. Strain-level identification was performed using both 16S rRNA gene sequences and whole-genome assemblies.An explicit criterion for inclusion of each strain in FB-001 and FB-003 DS-CoCl was demonstrated susceptibility to at least 2 FDA-approved antibiotics. The anaerobic microbes in the FB-001 DS-CoCl were tested against multiple FDA-approved, clinically relevant antimicrobials, most of which show especially potent activity against anaerobes. All strains in FB-001 and FB- 003 DS-CoCl were found to demonstrate sensitivity in vitro to 2 or more clinically relevant antibiotics, implying a straightforward means for biological control. Importantly, no strain in the FB-001 or FB-003 DS-CoCl were resistant to both clindamycin and amoxicillin-clavulanate, suggesting that a combination of the 2 agents could cover all FB-001 and FB-003 DS-CoCl strains.MCB generation is described in Figure 12. The first step of MCB generation for DS- CoCl strains involved reviving each RCB by plating on YCFAC agar plates followed by incubation under anaerobic conditions at 37°C. Isolated colonies were used for inoculating MCB precultures in 30 to 45 mL of YCFAC broth and were incubated anaerobically at 37°C. Each MCB was passaged 2 to 3 times in YCFAC broth prior to banking. Growth of precultures was monitored using total cell counts and viable cell counts to determine suitable time, inoculation, and culture volumes for MCB cultures. Sterility monitoring was performed by incub...

Claims

CLAIMS:

1. A method for preventing, decreasing, and / or treating dysbiosis in a subject, comprising administering an effective amount of a microbial consortium or a pharmaceutical composition thereof comprising a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, P ar abacter aides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis,Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides finegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum,Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; or b) FBI00001, FB 100002, FB 100010, FBI00013, FBI00029, FBI00032, FBI00033,FBI00034, FBI00043, FBI00044, FBI00048, FB 100050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FB 100117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FB 100206, FBI00211, FB 100220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof.

2. The method of claim 1 , wherein the microbial consortium or a pharmaceutical composition thereof further comprises: a) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutter ell a wadsworthensis, Sutter el la massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097,Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatiformans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; b) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiella tayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and / or c) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutter ell a excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereof.

3. The method of claim 1 , wherein the microbial consortium or a pharmaceutical composition thereof further comprises: a) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FBI00038,FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081,FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140,FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224,FBI00226, FBI00229, FBI00233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; b) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126,FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and / or c) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereof4. The method of claim 2 or 3, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067.

5. The method of claim 4, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a second strain of Oxalobacter formigenes or FBI00133.

6. The method of claim 5, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a third strain of Oxalobacter formigenes or FBI00289.

7. The method of claim 1 , wherein the microbial consortium or a pharmaceutical composition thereof comprises: a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides finegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum, Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; b) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutter ell a wadsworthensis, Sutter el la massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroidesfragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatif ormans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Diehna fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; c) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae,Eisenbergiella tayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and d) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila,Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia,Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereof.

8. The method of claim 1, wherein the microbial consortium or a pharmaceutical composition thereof comprises: a) FBI00001, FB 100002, FBI00010, FBI00013, FB 100029, FBI00032, FBI00033,FBI00034, FBI00043, FBI00044, FBI00048, FB 100050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FB 100117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FB 100206, FBI00211, FB 100220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof; b) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FB 100038, FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081, FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140, FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224,FBI00226, FBI00229, FBI00233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258, FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; c) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126, FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and d) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereof9. The method of claim 7, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FB 100067, a second strain of Oxalobacter formigenes or FB 100133, and a third strain of Oxalobacter formigenes or FBI00289.

10. The method of claim 8, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FB 100067, a second strain of Oxalobacter formigenes or FB 100133, and a third strain of Oxalobacter formigenes or FBI00289.

11. The method of claim 1 , wherein the microbial consortium or a pharmaceutical composition thereof is FB-001 or a functional equivalent thereof.

12. The method of claim 1 , wherein the microbial consortium or a pharmaceutical composition thereof is FB-003 or a functional equivalent thereof.

13. The method of any one of claims 1-12, wherein the microbial consortium or a pharmaceutical composition thereof increases the microbial diversity of the gastrointestinal tract.

14. The method of any one of claims 1-13, wherein the microbial consortium or a pharmaceutical composition thereof increases short chain fatty acids (SCFAs).

15. The method of any one of claims 1-14, wherein the microbial consortium or a pharmaceutical composition thereof increases secondary bile acids.

16. The method of any one of claims 1-15, wherein the microbial consortium or a pharmaceutical composition thereof decreases bacterial pathogens in the gastrointestinal tract of the subject.

17. The method of any one of claims 1-16, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 109and about 5 x 1012viable cells.

18. The method of any one of claims 1-16, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 109and about 5 * IO10viable cells.

19. The method of any one of claims 1-16, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x io10and about 5 x io11viable cells.

20. The method of any one of claims 1-16, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x io11and about 5 x io12viable cells.

21. The method of any one of claims 1-20, wherein the microbial consortium or a pharmaceutical composition thereof comprises up to about 1011viable cells.

22. The method of any one of claims 1-20, wherein the microbial consortium or a pharmaceutical composition thereof comprises up to about 1012viable cells.

23. The method of claim 1, wherein the method comprises administering a loading dose and one or more maintenance doses.

24. The method of claim 23, wherein the loading dose is administered for 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, or 10 days.

25. The method of claim 23 or 24, wherein the loading dose is administered for 2-3 days, 3-5 days, 4-6 days, or 5-7 days.

26. The method of any one of claims 23-25, wherein the one or more maintenance doses are administered for at least 21 days following the last loading dose.

27. The method of any one of claims 1-26 further comprising administering an antibacterial agent, an antiviral agent, an antifungal agent, anti-inflammatory agent, an immunosuppressive agent, and / or a prebiotic.

28. The method of claim 27, wherein the antibacterial agent is selected from the group consisting of ciprofloxacin, levaquin, fl oxin, tequin, avelox, norfl ox, cephalexin, cefuroxime, cefadroxil, cefazolin, cephalothin, cefaclor, cefamandole, cefoxitin, cefprozil, ceftobiprole, amoxicillin, ampicillin, penicillin V, dicloxacillin, carbenicillin, vancomycin, and methicillin, tetracycline, minocycline, oxytetracycline, doxycycline, ertapenem, doripenem, imipenem / cilastatin, and meropenem.

29. The method of claim 27, wherein the antiviral agent is selected from the group consisting of abacavir, acyclovir, adefovir, amprenavir, atazanavir, cidofovir, darunavir, delavirdine, didanosine, docosanol, efavirenz, elvitegravir, emtricitabine, enfuviltide, etravirine, famciclovir, foscamet, fomivirsen, ganciclovir, indinavir, idoxuridine, lamivudine, lopinavir maraviroc, mk- 2048, nelfmavir, nevirapine, nirmatrelvir, penciclovir, raltegravir, rilpivirine, ritonavir,saquinavir, stavudine, tenofovir trifluridine, valaciclovir, valganciclovir, vidarabine, ibacitabine, amantadine, oseltamivir, rimantidine, tipranavir, zalcitabine, zanamivir, and zidovudine.

30. The method of claims 27, wherein the antifungal agent is selected from the group consisting of miconazole, ketoconazole, clotrimazole, econazole, omoconazole, bifonazole, butoconazole, fenticonazole, isoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, fluconazole, itraconazole, isavuconazole, ravuconazole, posaconazole, voriconazok, terconazole, albaconazole, abafungin, terbinafine, naftifine, butenafine, anidulafungin, caspofungin, micafungin, polygodial, benzoic acid, ciclopirox, tolnaftate, undecylenic acid, flucytosine or 5- fluorocytosine, griseofulvin, and haloprogin31. The method of claims 27, wherein the anti-inflammatory and / or immunosuppressive agent is selected from the group consisting of cyclophosphamide, mycophenolate mofetil, corticosteroids, mesalazine, mesalamine, sulfasalazine, sulfasalazine derivatives, cyclosporin A, mercaptopurine, azathiopurine, prednisone, methotrexate, antihistamines, glucocorticoids, epinephrine, theophylline, cromolyn sodium, anti-leukotrienes, anticholinergics, monoclonal anti- IgE, immunomodulatory peptides, immunomodulatory small molecules, immunomodulatory cytokines, immunomodulatory antibodies, and vaccines.

32. The method of claims 27, wherein the prebiotic is selected from the group consisting of amino acids, biotin, fructooligosaccharides, galactooligosaccharides, inulin, lactulose, mannan oligosaccharides, oligofructose-enriched inulin, oligofructose, oligodextrose, tagatose, transgalactooligosaccharide, and xylooligosaccharides.

33. The method of any one of claims 1-32, wherein the microbial consortium or pharmaceutical composition thereof is present in a food product.

34. A method for restoring microbiome and / or recovering a healthy microbiome in a subject, comprising administering an effective amount of a microbial consortium or a pharmaceutical composition thereof comprising a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, P ar abacter aides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides finegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridiumbolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylamsolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis,Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum,Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; or b) FBI00001, FB 100002, FB 100010, FBI00013, FBI00029, FBI00032, FBI00033,FBI00034, FBI00043, FBI00044, FBI00048, FB 100050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FB 100117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FB 100206, FBI00211, FB 100220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof.

35. The method of claim 34, wherein the microbial consortium or a pharmaceutical composition thereof further comprises: a) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutter ell a wadsworthensis, Sutter el la massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatif ormans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; b) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus,Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiella tayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and / or c) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereof.

36. The method of claim 34, wherein t le microbial consortium or a pharmaceutical composition thereof further comprises: a) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FBI00038,FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081,FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140,FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224,FBI00226, FBI00229, FB 100233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; b) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126, FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and / or c) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereof.

37. The method of claim 35 or 36, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067.

38. The method of claim 37, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a second strain of Oxalobacter formigenes or FBI00133.

39. The method of claim 38, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a third strain of Oxalobacter formigenes or FBI00289.

40. The method of claim 34, wherein the microbial consortium or a pharmaceutical composition thereof comprises: a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacteriumeligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071 , Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides finegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum, Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; b) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutter ell a wadsworthensis, Sutter el la massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatif ormans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; c) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae,Eisenbergiella tayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and d) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, andSenegalimassilia anaerobia, or a functional equivalent thereof.

41. The method of claim 34, wherein the microbial consortium or a pharmaceutical composition thereof comprises: a) FBI00001, FBI00002, FBI00010, FBI00013, FBI00029, FBI00032, FBI00033, FBI00034, FBI00043, FBI00044, FBI00048, FBI00050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FBI00117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FBI00206, FBI00211, FBI00220, FBI00221, FBI00236, FBI00245,FBI00248. FBI00251. FBI00254. FB 100267. FBI00278. FBI00288. and FBI00290. or a functional equivalent thereof; b) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FB 100038,FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081,FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140, FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224, FBI00226, FBI00229, FB 100233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; c) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126, FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and d) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereof.

42. The method of claim 40, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, asecond strain of Oxalobacter formigenes or FBI00133, and a third strain of Oxalobacter formigenes orFBI00289.

43. The method of claim 41, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, a second strain of Oxalobacter formigenes or FBI00133, and a third strain of Oxalobacter formigenes orFBI00289.

44. The method of claim 34, wherein the microbial consortium or a pharmaceutical composition thereof is FB-001 or a functional equivalent thereof.

45. The method of claim 34, wherein the microbial consortium or a pharmaceutical composition thereof is FB-003 or a functional equivalent thereof.

46. The method of any one of claims 34-45, wherein the microbial consortium or a pharmaceutical composition thereof increases the microbial diversity of the gastrointestinal tract.

47. The method of any one of claims 34-46, wherein the microbial consortium or a pharmaceutical composition thereof increases short chain fatty acids (SCFAs).

48. The method of any one of claims 34-47, wherein the microbial consortium or a pharmaceutical composition thereof increases secondary bile acids.

49. The method of any one of claims 34-48, wherein the microbial consortium or a pharmaceutical composition thereof decreases bacterial pathogens in the gastrointestinal tract of the subject.

50. The method of any one of claims 34-49, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 109and about 5 x io12viable cells.

51. The method of any one of claims 34-50, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x io9and about 5 x io10viable cells.

52. The method of any one of claims 34-51, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x io10and about 5 x io11viable cells.

53. The method of any one of claims 34-52, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x io11and about 5 x io12viable cells.

54. The method of any one of claims 34-53, wherein the microbial consortium or a pharmaceutical composition thereof comprises up to about 1011viable cells.

55. The method of any one of claims 34-53, wherein the microbial consortium or a pharmaceutical composition thereof comprises up to about 1012viable cells.

56. The method of claim 34, wherein the method comprises administering a loading dose and one or more maintenance doses.

57. The method of claim 56, wherein the loading dose is administered for 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, or 10 days.

58. The method of claim 56 or 57, wherein the loading dose is administered for 2-3 days, 3-5 days, 4-6 days, or 5-7 days.

59. The method of any one of claims 56-58, wherein the one or more maintenance doses are administered for at least 21 days following the last loading dose.

60. The method of any one of claims 34-59 further comprising administering an antibacterial agent, an antiviral agent, an antifungal agent, anti-inflammatory agent, an immunosuppressive agent, and / or a prebiotic.

61. The method of claim 60, wherein the antibacterial agent is selected from the group consisting of ciprofloxacin, levaquin, fl oxin, tequin, avelox, norfl ox, cephalexin, cefuroxime, cefadroxil, cefazolin, cephalothin, cefaclor, cefamandole, cefoxitin, cefprozil, ceftobiprole, amoxicillin, ampicillin, penicillin V, dicloxacillin, carbenicillin, vancomycin, and methicillin, tetracycline, minocycline, oxytetracycline, doxycycline, ertapenem, doripenem, imipenem / cilastatin, and meropenem.

62. The method of claim 60, wherein the antiviral agent is selected from the group consisting of abacavir, acyclovir, adefovir, amprenavir, atazanavir, cidofovir, darunavir, delavirdine, didanosine, docosanol, efavirenz, elvitegravir, emtricitabine, enfuviltide, etravirine, famciclovir, foscamet, fomivirsen, ganciclovir, indinavir, idoxuridine, lamivudine, lopinavir maraviroc, mk- 2048, nelfmavir, nevirapine, nirmatrelvir, penciclovir, raltegravir, rilpivirine, ritonavir, saquinavir, stavudine, tenofovir trifluridine, valaciclovir, valganciclovir, vidarabine, ibacitabine, amantadine, oseltamivir, rimantidine, tipranavir, zalcitabine, zanamivir, and zidovudine.

63. The method of claims 60, wherein the antifungal agent is selected from the group consisting of miconazole, ketoconazole, clotrimazole, econazole, omoconazole, bifonazole, butoconazole, fenticonazole, isoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, fluconazole, itraconazole, isavuconazole, ravuconazole, posaconazole, voriconazok, terconazole, albaconazole, abafungin, terbinafine, naftifme, butenafine, anidulafungin, caspofungin, micafungin, polygodial, benzoic acid, ciclopirox, tolnaftate, undecylenic acid, flucytosine or 5- fluorocytosine, griseofulvin, and haloprogin64. The method of claims 60, wherein the anti-inflammatory and / or immunosuppressive agent is selected from the group consisting of cyclophosphamide, mycophenolate mofetil, corticosteroids, mesalazine, mesalamine, sulfasalazine, sulfasalazine derivatives, cyclosporin A, mercaptopurine, azathiopurine, prednisone, methotrexate, antihistamines, glucocorticoids,epinephrine, theophylline, cromolyn sodium, anti-leukotrienes, anticholinergics, monoclonal anti- IgE, immunomodulatory peptides, immunomodulatory small molecules, immunomodulatory cytokines, immunomodulatory antibodies, and vaccines.

65. The method of claims 60, wherein the prebiotic is selected from the group consisting of amino acids, biotin, fructooligosaccharides, galactooligosaccharides, inulin, lactulose, mannan oligosaccharides, oligofructose-enriched inulin, oligofructose, oligodextrose, tagatose, transgalactooligosaccharide, and xylooligosaccharides.

66. The method of any one of claims 34-65, wherein the microbial consortium or pharmaceutical composition thereof is present in a food product.

67. A method for treating a disease in a subject, comprising administering an effective amount of a microbial consortium or a pharmaceutical composition thereof comprising a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans,Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella hathewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella effluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides finegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis,Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum,Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; or b) FBI00001, FB 100002, FB 100010, FBI00013, FBI00029, FBI00032, FBI00033,FBI00034, FBI00043, FBI00044, FBI00048, FB 100050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FB 100117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FB 100206, FBI00211, FB 100220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof;wherein the disease is irritable bowel syndrome, diarrhea, constipation, celiac disease, and leaky gut syndrome, colitis, ulcerative colitis, or Crohn’s disease.

68. The method of claim 67, wherein the microbial consortium or a pharmaceutical composition thereof further comprises: a) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutterella wadsworthensis, Sutter el la massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatif ormans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; b) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiella tayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and / or c) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereof.

69. The method of claim 67, wherein the microbial consortium or a pharmaceutical composition thereof further comprises: a) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FBI00038, FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081,FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140,FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224,FBI00226, FBI00229, FBI00233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; b) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126, FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and / or c) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereof70. The method of claim 68 or 69, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067.

71. The method of claim 70, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a second strain of Oxalobacter formigenes or FBI00133.

72. The method of claim 71, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a third strain of Oxalobacter formigenes or FBI00289.

73. The method of claim 67, wherein the microbial consortium or a pharmaceutical composition thereof comprises: a) Clostridium citroniae, Bacteroides salyersiae, Blautia obeum, Parabacteroides merdae, Parabacteroides distasonis, Anaerostipes hadrus, Lachnospiraceae sp. FBI00033, Eubacterium eligens, Bifidobacterium dentium, Blautia wexlerae, Fusicatenibacter saccharivorans, Bacteroides nordii, Dorea formicigenerans, Dorea longicatena, Bacteroides stercorirosoris, Bifidobacterium longum, Bacteroides kribbi, Lachnospiraceae sp. FBI00071, Bacteroides thetaiotaomicron, Clostridium clostridioforme, Clostridium scindens, Roseburia hominis, Clostridium fessum, Coprococcus comes, Blautia faecis, Hungatella halhewayi, Bacteroides stercoris, Collinsella aerofaciens, Hungatella ejfluvii, Bifidobacterium adolescentis, Bifidobacterium catenulatum, Lactobacillus rogosae, Bacteroides faecis, Bacteroides fmegoldii, Clostridiaceae sp. FBI00191, Ruminococcus faecis, Lachnoclostridium pacaense, Clostridium bolteae, Longicatena caecimuris, Eggerthella lenta, Blautia massiliensis, Bacteroides xylanisolvens, Bacteroides vulgatus, Megasphaera massiliensis, Butyricimonas faecihominis, Eisenbergiella tayi, Acidaminococcus intestini, Emergencia timonensis, Bifidobacterium pseudocatenulatum, Eubacterium hallii, Anaerofustis stercorihominis, Eubacterium ventriosum,Blautia hydrogenotrophica, and Lachnospiraceae sp. FBI00290, or a functional equivalent thereof; b) Acutalibacter timonensis, Alistipes onderdonkii, Bacteroides uniformis, Eubacterium rectale, Alistipes timonensis, Bacteroides kribbi, Coprococcus eutactus, Bilophila wadsworthia, Bacteroides caccae, Alistipes shahii, Parasutterella excrementihominis, Paraprevotella clara, Sutterella wadsworthensis, Sutter el la massiliensis, Porphyromonas asaccharolytica, Ruminococcus bromii, Monoglobus pectinilyticus, Ruminococcaceae sp. FBI00097, Gordonibacter pamelaeae, Bacteroides uniformis, Gordonibacter pamelaeae, Bacteroides fragilis, Phascolarctobacterium faecium, Monoglobus pectinilyticus, Clostridium aldenense, Ruthenibacterium lactatif ormans, Bacteroides ovatus, Bifidobacterium bifidum, Anaerotruncus massiliensis, Clostridium aldenense, Sutterella wadsworthensis, Catabacter hongkongensis, Alistipes senegalensis, Ruminococcaceae sp. FBI00233, Alistipes shahii, Dielma fastidiosa, Eubacterium siraeum, Faecalibacterium prausnitzii, Turicibacter sanguinis, Eubacterium rectale, Bacteroides caccae, Methanobrevibacter smithii, Barnesiella intestinihominis, Alistipes onderdonkii, and Methanobrevibacter smithii, or a functional equivalent thereof; c) Bifidobacterium adolescentis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bacteroides thetaiotaomicron, Coprococcus comes, Fusicatenibacter saccharivorans, Eggerthella lenta, Eubacterium eligens, Bacteroides xylanisolvens, Lactobacillus rogosae, Clostridium citroniae, Collinsella aerofaciens, Blautia obeum, Eggerthella lenta, Blautia wexlerae, Lachnoclostridium pacaense, Bacteroides vulgatus, Parabacteroides merdae, Dorea formicigenerans, Ruminococcus faecis, Roseburia hominis, Anaerostipes hadrus, Bifidobacterium adolescentis, Bifidobacterium pseudocatenulatum, Clostridium bolteae, Eisenbergiella tayi, Dorea longicatena, Eggerthella lenta, Bacteroides stercoris, Hungatella hathewayi, and Bacteroides xylanisolvens, or a functional equivalent thereof; and d) Alistipes putredinis, Dialister succinatiphilus, Akkermansia muciniphila, Ruminococcus bromii, Dialister invisus, Bacteroides massiliensis, Bilophila wadsworthia, Holdemanella biformis, Parasutterella excrementihominis, Alistipes sp. FBI00180, Bacteroides coprocola, Alistipes sp. FBI00238, Alistipes putredinis, Eubacterium xylanophilum, and Senegalimassilia anaerobia, or a functional equivalent thereof.

74. The method of claim 67, wherein the microbial consortium or a pharmaceutical composition thereof comprises: a) FBI00001, FBI00002, FBI00010, FBI00013, FBI00029, FBI00032, FBI00033,FBI00034, FBI00043, FBI00044, FBI00048, FBI00050, FBI00051, FBI00057, FBI00059,FBI00060, FBI00070, FBI00071, FBI00076, FBI00079, FBI00087, FBI00093, FBI00102,FBI00109, FBI00117, FBI00120, FBI00125, FBI00127, FBI00128, FBI00145, FBI00162,FBI00174, FBI00184, FBI00190, FBI00191, FBI00194, FBI00198, FBI00199, FBI00200,FBI00201, FBI00205, FBI00206, FBI00211, FBI00220, FBI00221, FBI00236, FBI00245,FBI00248, FBI00251 , FBI00254, FB 100267, FBI00278, FBI00288, and FBI00290, or a functional equivalent thereof; b) FBI00004, FBI00012, FBI00015, FBI00018, FBI00019, FBI00021, FB 100038, FBI00040, FBI00046, FBI00061, FBI00066, FB 100075, FB 100077, FBI00080, FBI00081, FBI00085, FBI00092, FBI00097, FBI00099, FBI00112, FBI00132, FBI00137, FBI00140, FBI00149, FB 100151, FBI00176, FBI00189, FBI00197, FB 100208, FBI00212, FBI00224, FBI00226, FBI00229, FB 100233, FBI00235, FBI00237, FBI00243, FBI00244, FBI00258,FBI00260, FBI00263, FBI00270, FBI00273, FBI00277, and FB 100292, or a functional equivalent thereof; c) FBI00009, FBI00011, FBI00016, FBI00020, FBI00025, FBI00027, FBI00030, FBI00047, FBI00052, FBI00053, FBI00056, FBI00062, FBI00078, FBI00096, FBI00104, FBI00110, FBI00111, FBI00113, FBI00115, FBI00116, FBI00123, FBI00124, FBI00126,FBI00135, FBI00147, FBI00159, FBI00167, FBI00170, FBI00232, FBI00255, and FBI00271, or a functional equivalent thereof; and d) FBI00022, FBI00049, FBI00068, FBI00069, FBI00152, FBI00165, FBI00171, FBI00175, FBI00177, FB 100180, FBI00182, FBI00238, FB 100269, FBI00274, and FBI00281, or a functional equivalent thereof75. The method of claim 73, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, a second strain of Oxalobacter formigenes or FBI00133, and a third strain of Oxalobacter formigenes orFBI00289.

76. The method of claim 74, wherein the microbial consortium or a pharmaceutical composition thereof further comprises a first strain of Oxalobacter formigenes or FBI00067, a second strain of Oxalobacter formigenes or FBI00133, and a third strain of Oxalobacter formigenes orFBI00289.

77. The method of claim 67, wherein the microbial consortium or a pharmaceutical composition thereof is FB-001 or a functional equivalent thereof.

78. The method of claim 67, wherein the microbial consortium or a pharmaceutical composition thereof is FB-003 or a functional equivalent thereof.

79. The method of any one of claims 67-78, wherein the microbial consortium or a pharmaceutical composition thereof increases the microbial diversity of the gastrointestinal tract.

80. The method of any one of claims 67-79, wherein the microbial consortium or a pharmaceutical composition thereof increases short chain fatty acids (SCFAs).

81. The method of any one of claims 67-80, wherein the microbial consortium or a pharmaceutical composition thereof increases secondary bile acids.

82. The method of any one of claims 67-81, wherein the microbial consortium or a pharmaceutical composition thereof decreases bacterial pathogens in the gastrointestinal tract of the subject.

83. The method of any one of claims 67-82, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 109and about 5 * 1012viable cells.

84. The method of any one of claims 67-83, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 * 109and about 5 * IO10viable cells.

85. The method of any one of claims 67-84, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 1O10and about 5 x 1011viable cells.

86. The method of any one of claims 67-85, wherein the microbial consortium or a pharmaceutical composition thereof comprises between about 5 x 1011and about 5 x 1012viable cells.

87. The method of any one of claims 67-86, wherein the microbial consortium or a pharmaceutical composition thereof comprises up to about 1011viable cells.

88. The method of any one of claims 67-86, wherein the microbial consortium or a pharmaceutical composition thereof comprises up to about 1012viable cells.

89. The method of claim 67, wherein the method comprises administering a loading dose and one or more maintenance doses.

90. The method of claim 89, wherein the loading dose is administered for 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 8 days, 9 days, or 10 days.

91. The method of claim 89 or 90, wherein the loading dose is administered for 2-3 days, 3-5 days, 4-6 days, or 5-7 days.

92. The method of any one of claims 67-91, wherein the one or more maintenance doses are administered for at least 21 days following the last loading dose.

93. The method of any one of claims 67-92 further comprising administering an antibacterial agent, an antiviral agent, an antifungal agent, anti-inflammatory agent, an immunosuppressive agent, and / or a prebiotic.

94. The method of claim 93, wherein the antibacterial agent is selected from the group consisting of ciprofloxacin, levaquin, fl oxin, tequin, avelox, norfl ox, cephalexin, cefuroxime, cefadroxil, cefazolin, cephalothin, cefaclor, cefamandole, cefoxitin, cefprozil, ceftobiprole,amoxicillin, ampicillin, penicillin V, dicloxacillin, carbenicillin, vancomycin, and methicillin, tetracycline, minocycline, oxytetracycline, doxycycline, ertapenem, doripenem, imipenem / cilastatin, and meropenem.

95. The method of claim 93, wherein the antiviral agent is selected from the group consisting of abacavir, acyclovir, adefovir, amprenavir, atazanavir, cidofovir, darunavir, delavirdine, didanosine, docosanol, efavirenz, elvitegravir, emtricitabine, enfuviltide, etravirine, famciclovir, foscamet, fomivirsen, ganciclovir, indinavir, idoxuridine, lamivudine, lopinavir maraviroc, mk- 2048, nelfmavir, nevirapine, nirmatrelvir, penciclovir, raltegravir, rilpivirine, ritonavir, saquinavir, stavudine, tenofovir trifluridine, valaciclovir, valganciclovir, vidarabine, ibacitabine, amantadine, oseltamivir, rimantidine, tipranavir, zalcitabine, zanamivir, and zidovudine.

96. The method of claims 93, wherein the antifungal agent is selected from the group consisting of miconazole, ketoconazole, clotrimazole, econazole, omoconazole, bifonazole, butoconazole, fenticonazole, isoconazole, oxiconazole, sertaconazole, sulconazole, tioconazole, fluconazole, itraconazole, isavuconazole, ravuconazole, posaconazole, voriconazok, terconazole, albaconazole, abafungin, terbinafme, naftifine, butenafine, anidulafungin, caspofungin, micafungin, polygodial, benzoic acid, ciclopirox, tolnaftate, undecylenic acid, flucytosine or 5- fluorocytosine, griseofulvin, and haloprogin97. The method of claims 93, wherein the anti-inflammatory and / or immunosuppressive agent is selected from the group consisting of cyclophosphamide, mycophenolate mofetil, corticosteroids, mesalazine, mesalamine, sulfasalazine, sulfasalazine derivatives, cyclosporin A, mercaptopurine, azathiopurine, prednisone, methotrexate, antihistamines, glucocorticoids, epinephrine, theophylline, cromolyn sodium, anti-leukotrienes, anticholinergics, monoclonal anti- IgE, immunomodulatory peptides, immunomodulatory small molecules, immunomodulatory cytokines, immunomodulatory antibodies, and vaccines.

98. The method of claims 93, wherein the prebiotic is selected from the group consisting of amino acids, biotin, fructooligosaccharides, galactooligosaccharides, inulin, lactulose, mannan oligosaccharides, oligofructose-enriched inulin, oligofructose, oligodextrose, tagatose, transgalactooligosaccharide, and xylooligosaccharides.

99. The method of any one of claims 67-98, wherein the microbial consortium or pharmaceutical composition thereof is present in a food product.

100. The method of any one of claims 67-99, further comprising diagnosing IBD in the subject before administration of the microbial consortium or pharmaceutical composition thereof.

101. A method for decreasing dysbiosis in a subject, the method comprising administering to a patient a therapeutically effective amount of a pharmaceutical composition comprising a Consortia to decrease dysbiosis of the gastrointestinal tract in the patient.

102. The method of claim 101, wherein decreasing dysbiosis comprises engraftment of microbes of the Consortia, increase in the microbial diversity of the gastrointestinal tract, increase in the short chain fatty acids (SCFAs), increase in secondary bile acids, and / or decrease of bacterial pathogens.

103. The methods of claims 101 or 102, wherein the Consortia is FB-001 or a functional equivalent thereof.

104. The methods of claims 101 or 102, wherein the Consortia is FB-003 or a functional equivalent thereof.

105. A method for restoring the microbiome in a patient, the method comprising administering to the patient a therapeutically effective amount of a pharmaceutical composition comprising a Consortia.

106. The method of claim 105, wherein the restoring the microbiome comprises engraftment of microbes of the Consortia, increase in the microbial diversity of the gastrointestinal tract, increase in the short chain fatty acids (SCFAs), increase in secondary bile acids, and / or decrease of bacterial pathogens.

107. The methods of claims 105 or 106, wherein the Consortia is FB-001 or a functional equivalent thereof.

108. The methods of claims 105 or 106, wherein the Consortia is FB-003 or a functional equivalent thereof.

109. A method for increasing the recovery of a healthy microbiome in a patient after a dysbiosis inducing event, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a Consortia.

110. The method of claim 109, wherein the recovery of a healthy microbiome comprises engraftment of microbes of the Consortia, increase in the microbial diversity of the gastrointestinal tract, increase in the short chain fatty acids (SCFAs), increase in secondary bile acids, and / or decrease of bacterial pathogens.

111. The methods of claims 109 or 110, wherein the Consortia is FB-001 or a functional equivalent thereof.

112. The methods of claims 109 or 110, wherein the Consortia is FB-003 or a functional equivalent thereof.

113. The method of any of claims 109-112 wherein the dysbiosis inducing event is treatment with one or more antibiotics, an infectious disease, or an underlying disease.

114. The method of claim 113, wherein the underlying disease is IBD, colitis, ulcerative colitis, or Crohn’s disease.

115. A composition for treating or reducing a severity of at least one symptom of a gastrointestinal disease, disorder or condition associated with a dysbiosis in a patient, the composition comprising a Consortia in an amount effective to populate and optionally engraft in a gastrointestinal tract in the patient.

116. The composition of claim 115, wherein the gastrointestinal disease is selected from the group consisting of IBD, colitis, ulcerative colitis, and Crohn’s disease.

117. The composition of claims 115 and 116, wherein the dysbiosis is associated with a decrease in the microbial diversity of the gastrointestinal tract, a decrease in the short chain fatty acids (SCFAs), a decrease in secondary bile acids, and / or an increase of bacterial pathogens.

118. The methods of any of claims 115-117, wherein the Consortia is FB-001 or a functional equivalent thereof.

119. The methods of any of claims 115-117, wherein the Consortia is FB-003 or a functional equivalent thereof.

120. A method of treating or reducing a severity of at least one symptom of a gastrointestinal disease associated with a dysbiosis, the method comprising administering an effective amount of a pharmaceutical composition comprising a Consortia.

121. The methods of claim 120, wherein the Consortia is FB-001 or a functional equivalent thereof.

122. The methods of claim 120, wherein the Consortia is FB-003 or a functional equivalent thereof.

123. A composition comprising FB-003 or a functional equivalent thereof.

124. A method of making FB-003 or a functional equivalent thereof.

125. A method of treating IBD, colitis, ulcerative colitis, or Crohn’s disease by administering a Consortia.

126. The method of claim 125, wherein the Consortia is FB-003 or FB-001.

127. A method of reducing the symptoms associated with IBD, colitis, ulcerative colitis, or Crohn’s disease by administering a Consortia.

128. The method of claim 127, wherein the Consortia is FB-003 or FB-001.

129. Any method or composition described herein.

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