Biomarkers of the integrated stress response and uses thereof

EP4754294A1Pending Publication Date: 2026-06-10CALICO LIFE SCI LLC
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Patent Information

Authority / Receiving Office
EP · EP
Patent Type
Applications
Current Assignee / Owner
CALICO LIFE SCI LLC
Filing Date
2024-08-02
Publication Date
2026-06-10

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Abstract

The present disclosure provides, based on GDF15 expression, compositions and methods useful in modulating integrated stress response (ISR) and associated diseases or disorders and methods of identifying ISR modulators. The present disclosure also provides methods of treating neurodegenerative conditions and predicting beneficial effects and identifying suitable targets for treatment. Exemplified are elF2B modulators as therapeutic agents.
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