Salt-loaded solid lipid nanoparticles loaded with an active agent
EP4757779A1Pending Publication Date: 2026-06-17PURDUE RES FOUND
Patent Information
- Authority / Receiving Office
- EP · EP
- Patent Type
- Applications
- Current Assignee / Owner
- PURDUE RES FOUND
- Filing Date
- 2024-08-08
- Publication Date
- 2026-06-17
AI Technical Summary
Technical Problem
There is a lack of research on drug-loaded carriers, particularly those loaded with anionic drugs like phosphates, carboxylates, and phenolates, which can form ionic complexes/salts with cationic lipids in solid lipid nanoparticles (SLNs).
Method used
The development of solid lipid nanoparticles (SLNs) that incorporate anionic forms of drugs, such as phosphates, phenolates, or carboxylates, which form ionic complexes or salts with cationic lipids like SM-102 or ALC-0315, DSPC, cholesterol, and DMG-PEG-2000 or ALC-0159, enhancing drug stability and delivery.
Benefits of technology
The proposed SLN system achieves improved drug stability, enhanced drug delivery, and increased bioavailability, while maintaining stability for at least 29 days under refrigerated conditions.
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Smart Images
Figure US2024041402_20022025_PF_FP_ABST
Abstract
A solid lipid nanoparticle (SLN) comprising an anionic form of a drug, which comprises a phosphate, a phenolate, or a carboxylate, entrapped in (a) a cationic form of the lipid SM-102 or a cationic form of the lipid ALC-0315, (b) distearoylphosphatidylcholine, (c) cholesterol, and (d) 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 or ALC-0159, wherein the anionic form of the drug and the cationic form of the lipid of (a) form an ionic complex or a salt; a SLN comprising an anionic form of a drug, which comprises a phosphate, a phenolate, or a carboxylate, entrapped in dimethyldidodecylammonium bromide or 1,2-dioleoyl-3-trimethylammonium-propane; pharmaceutical compositions comprising the SLNs; and methods of making the SLNs.
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