Fgfr4 as target in cancer treatment
EP4761765A2Pending Publication Date: 2026-06-24ONA THERAPEUTICS SL +5
Patent Information
- Authority / Receiving Office
- EP · EP
- Patent Type
- Applications
- Current Assignee / Owner
- ONA THERAPEUTICS SL
- Filing Date
- 2024-08-12
- Publication Date
- 2026-06-24
AI Technical Summary
Technical Problem
Current treatments for hormone receptor-positive (HR+) breast cancer, particularly those involving CDK4/6 inhibitors, face challenges due to the development of resistance mechanisms, necessitating the identification of new therapeutic approaches.
Method used
The use of FGFR4 as a predictive biomarker to determine the effectiveness of CDK4/6 inhibitor therapy, combined with the development of FGFR4-binding molecules or inhibitors, such as antibody-drug conjugates (ADCs), to target and overcome resistance in cancer treatment.
Benefits of technology
FGFR4 expression levels can predict response to CDK4/6 inhibitor therapy, and targeting FGFR4 with specific ADCs can restore sensitivity to CDK4/6 inhibitors and improve treatment outcomes for HR+ breast cancer patients.
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Smart Images
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Abstract
The present invention provides new therapeutic approaches for the treatment or prevention of FGFR4-expressing cancers, including those resistant to other therapies.
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