Cell selection
EP4762358A1Pending Publication Date: 2026-06-24CYTOMOS
Patent Information
- Authority / Receiving Office
- EP · EP
- Patent Type
- Applications
- Current Assignee / Owner
- CYTOMOS
- Filing Date
- 2024-11-27
- Publication Date
- 2026-06-24
AI Technical Summary
Technical Problem
Current methods for selecting high-yielding cell lines for recombinant protein production are labor-intensive and costly, often requiring extensive screening and failing to predict cell performance when scaled up.
Method used
The use of impedance or dielectric spectroscopy to rapidly identify high-yielding cell lines by measuring frequency differences indicative of polypeptide expression, allowing for label-free, efficient cell selection.
Benefits of technology
This method enables rapid and cost-effective identification of high-yielding cell lines, improving the efficiency of recombinant protein production and reducing the challenges associated with scaling up cell cultures.
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Smart Images
Figure GB2024052975_05062025_PF_FP_ABST
Abstract
The disclosure concerns the use of di-electric spectroscopy for the selection of cells, typically cells engineered by recombinant methods, but also including antibody producing hybridoma cell lines, that express a polypeptide, such as an antibody, CAR-T cells, induced pluripotent stem (IPS) cells and cells derived from IPS cells.
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