FILM-FORMING COMPOSITION AND ITS USE IN THE TREATMENT OF SKIN CONDITIONS

Abstract

The present invention therefore relates to a film-forming composition intended to be applied to the skin, hair, or mucous membranes, containing at least two grades of hydroxypropylcellulose, at least one of which has a molecular weight of at least 800,000 and the other a molecular weight of less than 400,000, at least one plasticizer, at least one organic solvent, and at least one inorganic solvent, characterized in that: (a) the hydroxypropylcellulose having a molecular weight of at least 800,000 represents from 0.2 to 4% by weight of the total weight of the composition, (b) the hydroxypropylcellulose having a molecular weight of less than 400,000 represents from 0.2 to 20% by weight of the total weight of the composition, (c) the plasticizer represents from 0.5 to 10% by weight of the total weight of the composition, (d) the inorganic solvent represents from 10 to 60% by weight of the total weight of the composition, (e) the organic solvent represents 40 to 80% by weight of the total weight of the composition.

Description

glycol esters such as triacetin (or glyceryl triacetate); propylene glycol derivatives and in particular propylene glycol phenyl ether, propylene glycol diacetate, dipropylene glycol ethyl ether, tripropylene glycol methyl ether, propylene glycol butyl ether; acid esters, particularly carboxylic acids, such as citrates, phthalates, adipates, carbonates, tartrates, phosphates, sebacates and in particular monocarboxylic acid esters such as isononyl isononanoate, oleyl erucate or octyl-2-docecyl neopentanoate; oxyethylenated derivatives, such as oxyethylenated oils, including vegetable oils such as sesame oil, castor oil, almond oil, canola oil, hazelnut oil, pistachio oil, linseed oil, borage oil, Hemp oil, jojoba oil, sunflower oil, wheat germ oil, corn and / or corn germ oil, peanut oil, avocado oil, safflower oil, rapeseed oil, olive oil, argan oil, sunflower oil, grapeseed oil, soybean oil, walnut oil, pumpkin seed oil, palm oil, coconut oil, and mixtures thereof. The oil may also be a derivative of one of the vegetable oils mentioned above. It may be hydrogenated or non-hydrogenated, peroxidized or non-peroxidized; and their mixtures. In a preferred embodiment, the plasticizer is chosen from among the glycols, particularly glycerin. Indeed, glycerin has the advantage of softening the film, moisturizing the skin (or mucous membrane), and promoting the diffusion of the active ingredient(s) when the composition contains them. The plasticizer content can range from 0.5% to 10% by weight, and in particular from 2% to 5% by weight, relative to the total weight of the composition. Solvents The compositions of the invention contain at least one organic solvent and at least one inorganic solvent. These solvents allow some or all of the ingredients in the composition to be solubilized and contribute to the formation of a film on the skin when applied. Examples of organic solvents that can be used in the context of the present invention include: - ketones such as methyl ethyl ketone, methyl isobutyl ketone, diisobutyl ketone, isophorone, cyclohexanone, acetone; - alcohols such as ethanol, isopropanol, n-propanol, n-butanol, diacetone alcohol, 2-butoxyethanol, cyclohexanol; - propylene glycol ethers such as propylene glycol monomethyl ether, propylene glycol monomethyl ether acetate, dipropylene glycol mono n-butyl ether; - esters such as ethyl acetate, methyl acetate, propyl acetate, n-butyl acetate, isopentyl acetate; - ethers such as diethyl ether, dimethyl ether or dichlorodiethyl ether; and - mixtures thereof. The organic solvent represents 40 to 80% by weight of the total weight of the composition, preferably 50 to 70% by weight of the total weight of the composition. According to a preferred embodiment, the organic solvent is volatile. The term "volatile organic solvent" refers to an organic solvent capable of evaporating upon contact with the skin in less than one hour, at room temperature and atmospheric pressure. The volatile organic solvent is liquid at room temperature, and in particular has a non-zero vapor pressure at room temperature and atmospheric pressure; specifically, it has a vapor pressure ranging from 0.13 Pa to 40,000 Pa (10⁻¹ to 300 mm Hg), and preferably ranging from 1.3 Pa to 8,000 Pa (0.01 to 60 mm Hg). According to a particularly preferred embodiment, the organic solvent is chosen from liquid alcohols at room temperature such as ethanol, isopropanol, diacetone alcohol, 2-butoxyethanol, cyclohexanol and mixtures thereof, and preferably ethanol. The inorganic solvent represents 10 to 60% by weight of the total weight of the composition, preferably 20 to 40% by weight of the total weight of the composition. The inorganic solvent will advantageously be water. The Applicant observed that combining these two solvents in such proportions advantageously achieved a good compromise between drying time and the pain experienced when applying the composition to damaged skin. Indeed, ethanol has the advantage of evaporating rapidly but causes pain upon application. Adding water in this proportion reduces the pain while maintaining an acceptable drying time (specifically, less than 120 seconds). The best results are obtained when the organic solvent / inorganic solvent weight ratio is between 0.7 and 8, preferably between 1.5 and 4. Another advantage of using a mixture of organic and inorganic solvent is that a greater number of compounds can be dissolved, such as active ingredients. Additives The composition according to the invention may include one or more pharmaceutically acceptable additives, such as perfumes, aromas, colorants, pigments, mattifying agents, rheological agents, preservatives, vitamins, essential oils and active agents, in particular selected from antibacterial agents, antiseptics, antivirals, antifungal agents, pain relievers, anti-inflammatories, healing agents, moisturizing agents, depigmenting agents, keratolytic agents, restructuring agents, anesthetics and sunscreens. In particular, the active ingredients that can be introduced into the composition according to the invention can be chosen from: antibacterials such as Polymyxin B, penicillins (Amoxicillin), clavulanic acid, tetracyclines, Minocycline, chlorotetracycline, aminoglycosides, Amikacin, Gentamicin, Neomycin, silver and its salts (silver sulfadiazine), probiotics; antiseptics such as sodium mercurothiolate, eosin, chlorhexidine, phenylmercury borate, hydrogen peroxide, Dakin's solution, triclosan, biguanide, hexamidine, thymol, Lugol's solution, povidone-iodine, merbromine, benzalkonium and benzethonium chloride, ethanol, isopropanol; antivirals such as Aciclovir, Famciclovir, Ritonavir; antifungals such as polyenes, Nystatin, Amphotericin B, Natamycin, imidazoles (Miconazole, Ketoconazole, Clotrimazole, Econazole, Bifonazole, Butoconazole, Fenticonazole, Isoconazole, Oxiconazole, Sertaconazole, Sulconazole, Thiabendazole, Tioconazole), triazoles (Fluconazole, Itraconazole, Ravuconazole, Posaconazole, Voriconazole), allylamines, Terbinafine, Amorolfine, Naftifine, Butenafine; Flucytosine (antimabolite), Griseofulvin, Caspofungin, Micafungin; painkillers such as Paracetamol, Codeine, Dextropropoxyphene, Tramadol, Morphine and its derivatives, Corticosteroids and derivatives; anti-inflammatory drugs such as glucocorticoids, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, ibuprofen, ketoprofen, flurbiprofen, diclofenac, aceclofenac, ketorolac, meloxicam, piroxicam, and tenoxicam, Naproxen, Indomethacin, Naproxcinod, Nimesulide, Celecoxib, Etoricoxib, Parecoxib, Rofecoxib, Valdecoxib, Phenylbutazone, Niflumic acid, Mefenamic acid; active ingredients promoting healing such as Retinol, Vitamin A, Vitamin E, N-acetyl-hydroxyproline, Centella Asiatica extracts, papain, silicones, essential oils of thyme, niaouli, rosemary, tea tree and sage, hyaluronic acid, synthetic polysulfated oligosaccharides having 1 to 4 sugar units such as potassium salt of sucrose octasulfate, silver salt of sucrose octasulfate or sucralfate, allantoin; moisturizing agents such as hyaluronic acid, urea, glycerol, fatty acids, aquaporin modulators, vegetable oils, chitosan, certain sugars including sorbitol, butters and waxes; depigmenting agents such as kojic acid (KojicAcid SL® - Quimasso (Sino Lion)), arbutin (Olevatin® - Quimasso (Sino Lion)), a mixture of sodium palmitoylpropyl and white water lily extract (Sepicalm® - Seppic), undecylenoyl phenylalanine (Sepiwhite® - Seppic), licorice extract obtained by fermentation of Aspergillus and ethoxydiglycol (GatulineWhitening® - Gattefossé), octadecenedioic acid (ODA White® - Sederma), alpha-arbutin (Alpha-arbutin®, SACLCFPA (Pentapharm)), aqueous extract of Arctophylos Uva Ursi leaves (Melfade-J® - SACLCFPA (Pentapharm)), Gigawhite® complex plant mixture (SACLCFPA (Alpaflor)), the Diacetylboldine (Lumiskin® - Sederma), Japanese mandarin extract (Melaslow® - Sederma), a blend of lemon extract enriched with citric acid and cucumber extract (Uninontan®U-34 - Unipex), a blend of Rumex occidentalis extract and vitamin C (Tyrostat® 11 - Unipex), oligopeptides (Melanostatin 5® - Unipex),dipalmitatekojic acid (KAD-15® - Quimasso (Sino Lion)), LCW's naturally derived Vegewhite® complex, wheat germ extracts (Clariskin® II - Silab), ethyldiaminetriacetate (EDTA); , Keratolytic agents such as salicylic acid, zinc salicylate, ascorbic acid, alpha hydroxy acids (glycolic, lactic, malic, citric, tartaric acid), extracts of silver maple, sour cherry, tamarind, urea, the topical retinoid Keratoline® (Sederma), and proteases obtained by fermentation from Bacillus Subtilis, the product Linked-Papain® (SACI-CFPA), papain (proteolytic enzyme from papaya fruit); restructuring actives (e.g. hair and nail restructuring agents) such as silica derivatives, vitamin E, chamomile, calcium, horsetail extract, silk Lipester; anesthetics such as benzocaine, lidocaine, dibucaine, pramoxine hydrochloride, bupivacaine, mepivacaine, prilocaine, etidocaine; sunscreens, such as chemical filters (Oxybenzone, Sulisobenzone, Dioxybenzone, Tinosorb S®, Avobenzone, 2-ethoxyethyl p-methoxycinnamate, Uvinul® A+, Mexoryl® XL, Octyl methoxycinnamate or octinoxate, Octyl salicylate or octisalate, Octyl triazone or Uvinul® T 150, Methyl salicylate, Meradimate, Enzacamene, MBBT or Tinosorb® M, Octyl cyanophenylcinnamate or Parsol® 340, Para-aminobenzoic acid, Ensulizole, Parsol® SLX or Polysiloxane-15 or Benzylidene malonate polysiloxane, Triethanolamine salicylate or Trolamine salicylate, Mexoryl® SX or Terephthalylidene dicamphosulfonic acid) and mineral filters (zinc oxides, titanium dioxide, kaolin, ichthyol). Preferably, when the composition is used in the treatment of acne, it includes a keratolytic agent, preferably salicylic acid in combination with an active ingredient that promotes healing, preferably tea tree essential oil. As previously stated, the composition according to the present invention is in the form of a liquid intended to be applied using a suitable applicator, such as a brush, palette, spray, roll-on, spatula or pen. Use of the composition The compositions according to the present invention are intended to be applied to the skin, hair, nails, or mucous membranes. They can be advantageously used on wounds or scars, whether related to an accident, illness, or the aftermath of surgery, burns, blisters, chapped skin, or cracks, in the treatment of skin conditions such as, for example, acne, chickenpox, shingles, rosacea, and burns. In the first degree, eczema, hyperpigmentation, incite, vitiligo, xerosis, porphyria, stretch marks, psoriasis, insect bites, herpes, canker sores. The invention therefore relates to the composition as defined above for its use in the protection or treatment of wounds, scars, burns, blisters, fungal infections, chapped skin, cracks, acne, chickenpox, shingles, rosacea, eczema, hyperpigmentation, lucite, vitiligo, xerosis, prophyria, stretch marks, psoriasis, insect bites, herpes, and canker sores. The invention relates in particular to the composition as defined above for its use in a method of treating acne. Acne is an inflammatory dermatosis of the pilosebaceous follicles (sebum-secreting glands at the root of the hairs) with the formation of comedones. Acne is a skin condition affecting the pilosebaceous follicles. In this condition, the hair follicle becomes blocked by sebum and dead skin cells, leading to various lesions resulting from sebum retention, inflammation, or infection of the pilosebaceous follicles. Propionibacterium acnes is a bacterium that normally lives in the hair follicles of everyone. It does not cause infection, but it worsens follicle inflammation when there is excess sebum, leading to red pimples. Among the known treatments are creams and ointments. These are primarily based on benzoyl peroxide and are available in pharmacies (without a prescription). They are at least as effective as antibiotics and appear to be more active than topical retinoids in inflammatory forms. Benzoyl peroxide can be irritating at high concentrations, which are no more effective than lower concentrations. Some products target the bacteria (Propionibacterium acnes), while others act on inflammatory mediators, such as nicotinamide, a molecule naturally present in many foods. Zinc, on the other hand, helps reduce sebum secretion. Topical retinoids are effective in inflammatory forms and on comedones. However, they are irritating at the beginning of treatment, sometimes causing eczema (rarely) and photosensitivity. They are teratogenic. (possible malformation of a fetus before birth) and require the woman to take a contraceptive. By applying the composition according to the invention to a skin eruption at the first signs of the lesion, it is possible to limit the formation of comedones, papules, pustules, or nodules. When applied after comedones have formed, the composition according to the invention helps to limit the formation of papules, pustules, or nodules. Finally, the film obtained with the compositions of the invention also helps to promote the healing of comedones, papules, pustules and nodules. Cosmetic treatment method The present invention also relates to a cosmetic skin treatment method, comprising at least one application of the composition according to the present invention to skin imperfections every 24 hours in order to improve the appearance of the skin. The present invention is illustrated in more detail in the non-limiting examples described below. Example 1: Composition Formulations The formulations of examples 1 to 17 were created following the following protocol: The active ingredients (example 17) are added to the ethanol while stirring continuously for 15 minutes. Then, water and glycerin are added (still while stirring). Hydroxypropylcellulose with a molecular weight below 400,000 (Klucel GF, JF, or LF) is sprinkled into the mixture and then left to stir for approximately one hour (examples 2 to 5, 7 to 17). Once this grade of hydroxypropylcellulose is thoroughly incorporated, the high molecular weight hydroxypropylcellulose (Klucel MF) is added gradually and the mixture is stirred for approximately two hours. Stirring is then stopped, and the mixture is left to stand for about 12 hours to allow the hydroxypropylcellulose to fully swell before the final product is packaged. Examples of film formation / adhesion Example 1 comparative Example 2 comparative Example 3 comparative Example 4 comparative Examples comparative Trade name Manufacturer / Supplier INCI name CAS no. % mass % mass % mass % mass % mass Klucel MF HERCULES Hydroxypropyl cellulose 9004-64-2 5 2 2 2 2 Klucel GF HERCULES Hydroxypropyl cellulose 9004-64-2 3 Klucel JF HERCULES Hydroxypropyl cellulose 9004-64-2 3 Klucel LF HERCULES Hydroxypropyl cellulose 9004-64-2 3 Glycerin 4810 Sigma-Aldrich glycerol 56-81-5 0 0 0 0 0 Ethanol absolute Charbonneau Brabant Alcohol 64-17-5 70 72 70 70 70 Water 25 26 25 25 25 Example 2: Testing the durability of film-forming compositions over time 10. A panel of 10 people tested the compositions of examples 1 to 5 on the following criteria: Film formation and protective sensation after drying. Film durability at 1 hour, 2 hours, 4 hours and 8 hours. The panelists are summoned in the morning, they apply formulas 1 to 5 to their cheeks with a silicone spatula (1, 3 and 5 on the right cheek and 2 and 4 on the left cheek). Evaluation Time Question Comparative Example 1 Comparative Example 2 Comparative Example 3 to 5 Comparative Immediately after drying Film formation and appearance Difficult to apply formula, too viscous, does not dry 90% of people do not perceive a film after drying 100% of people perceive a film after drying Discreet film 1 hour after Film presence - 100% No 50 to 70% Yes 30 to 50% of the panel removed the film because there was excessive peeling. Film appearance - Absence The film is still present but peeling at the edges and cracking is present 2 hours after Film presence - - 80 to 90% No 10 to 20% Yes Film appearance The films either fell off on their own or were removed because they were too peeled or too cracked with an unsightly appearance. The remaining film is very cracked 4 hours after film presence - - All films have fallen off or been removed Film appearance - - - 8 hours after film presence - - - Film appearance - - - Comparative formulas obtained with a single polymer are thus either too viscous to allow acceptable application (example 1), or do not leave a film thick enough to be perceived (example 2). 5 Mixing two Klucel of different grades (examples 3 to 5) allows the formation of a physical film perceptible to the panelist but which does not last long enough because it cracks and peels off at the edges, causing spontaneous withdrawal of the panelists. Examples aesthetic / outfit E\ein,)le 6 conifiarative Example 7 Inv. Example 8 Inv. E\ein,)le 9 Inv. Example 10 Comparative E\ein,)le 11 Comparative Non-commercial Manufacturer / Supplier INCI Name CAS No. % mass % mass % mass % mass % mass % mass Klucel MF HERCULES Hydroxypropylcellulose 9004-64-2 2 1 1 1 1 1 Klucel GF HERCULES Hydroxypropylcellulose 9004-64-2 5 Klucel JF HERCULES Hydroxypropylcellulose 9004-64-2 5 Klucel LF HERCULES Hydroxypropylcellulose 9004-64-2 5 5 5 Glycerin 4810 Sigma-Aldrich Glycerol 56-81-5 3 3 3 3 15 0.3 Absolute Ethanol Charbon-neau Brabant Alcohol 64-17-5 70 67 67 67 58 69 Water 25 24 24 24 21 24.7 5. A panel of 10 people tested the compositions of examples 6 to 11 on the following criteria: Film formation and a feeling of protection after drying Film screenings at 1:00, 2:00, 4:00 and 8:00 Aspect of the film formed 0 The panelists are summoned in the morning, they apply formulas 6 to 11 to their cheeks with a silicone spatula (6, 8 and 10 on the right cheek and 7, 9 and 11 on the left cheek). Evaluation time Question Example 6 comparative Example 7 to 9 Invention Example 10 comparative Example 11 comparative Just after drying Film formation and appearance No sensation of the presence of a film Formation of a flexible and very discreet film The film does not dry and remains sticky.Immediate removal. Formation of a discreet film after drying. 1 hour after film presence: - 100% film still present - 90% film present - 10% film removed because it was too peeled. Film appearance: - Discreet, flexible and comfortable film - Cracked and peeled films at the edges. 2 hours after film presence: - 100% film still present - 90% film removed because it was unsightly or too peeled. Film appearance: - Discreet, flexible and comfortable film - Cracked, white film, peeled over a large area. 4 hours after film presence: - 100 to 90% film still present - 100% film absent. Film appearance: - Discreet, flexible and comfortable film. - - 8 hours after film presence: - 80 to 70% film still present - - Film appearance: - Discreet, flexible and comfortable film. - - . Formulas containing glycerin allow for better long-term stability of the films formed (examples 7 to 9). Glycerin with a single grade of hydroxypropylcellulose does not allow the formation of a 5 protective film (example 6). A high concentration of glycerin prevents the film from drying out, it remains sticky (example 10). Too low a concentration of glycerin does not allow the film to become flexible; it cracks and falls off quickly (example 11). Examples of drying time / pain Example 12 comparative Example 13 Inv. Example 14 Inv. Example 15 comparative Example 16 Inv. Trade Name Manufacturer Supplier INCI Name CAS No. % mass % mass % mass % mass % mass Klucel MF HERCULES hydroxyprop ylcellulose 9004-64-2 1 1 1 1 1 Klucel GF HERCULES hydroxyprop ylcellulose 9004-64-2 Klucel JF HERCULES hydroxyprop ylcellulose 9004-64-2 Klucel LF HERCULES hydroxyprop ylcellulose 9004-64-2 5 5 5 5 5 Glycerin 4810 Sigma-Aldrich glycerol 56-81-5 3 3 3 3 3 Ethanol absolute Charbonneau Brabant Alcohol 64-17-5 24 40 80 90 60 Water 67 51 11 1 31 5. A panel of 6 people with irritated hand skin due to the cold tested the compositions of examples 12 to 16 on the following criteria: Film drying time Pain upon application 10 The panelists are summoned in the morning, they apply formulas 12 to 16 to their hands with a silicone spatula (12, 14 and 16 on the right hand and 13 and 15 on the left hand). The results are presented in the following table: Evaluation Example 12 Comparative Example 13 Inv. Example 14 Inv. Example 15 Comparative Example 16 Inv. Drying time >5 min 6 / 6 1 / 6 2 min - 5 min 4 / 6 1 / 6 1 / 6 < 2 min 5 / 6 6 / 6 5 / 6 Pain on application Unacceptable pain 2 / 6 4 / 6 Sharp but acceptable pain 4 / 6 3 / 6 2 / 6 4 / 6 Acceptable pain 6 / 6 2 / 6 1 / 6 2 / 6 No pain Too high a water content combined with too low an ethanol content prevents the film from drying. A drying time greater than 5 minutes is unacceptable (example 12). 5. Too low a water content combined with too high an ethanol content favors drying time. However, increasing it can be detrimental with regard to the pain felt (example 15). An acceptable compromise must therefore be found to reconcile the two expectations. Examples 13, 14, and 16 thus offer a better compromise, with example 16 providing the best 10 results out of all formulas tested. Example 17 Trade Name Manufacturer / Supplier INCI Name CAS No. % by Mass Klucel MF HERCULES hydroxypropylcellulose 9004-64-2 1.5 Klucel LF HERCULES hydroxypropylcellulose 9004-64-2 4 Glycerin 4810 Sigma-Aldrich glycerol 56-81-5 3 Ethanol absolute Charbonneau Brabant Alcohol 64-17-5 60.5 Water 30.7 Salicylic acid Rhodia Salicylicacid 69-72-7 0.15 Tea tree oil TeatreeoilAustralia 0.15 The mixture of two active ingredients: 0.15% salicylic acid and 0.15% tea tree essential oil, showed promising efficacy against the Propionobacter acnes strain according to the NF EN 1040 April 2006 standard, with the following neutralizing agent: Polysorbate 80 30.0 g Saponin 30.0 g L-Histidine 1.0 g Lecithin 3.0 g Sodium Thiosulfate 5.0 g Sodium Chloride 8.5 g Tryptone 1.0 g Distilled Water 1000.0 ml Sterilized in an autoclave at a temperature of 121-0 / +3 °C for at least 15 minutes. Q The inoculum used was 2.2 x 10⁶ CFU / mL of a Propionibacterium acnes CIP strain 53.117T. The incorporation of this mixture into formulas previously tested for their film-forming properties, long-lasting, quick-drying and relatively painless application on damaged skin is of particular interest in the treatment of acne pimples.

Claims

Demands 1. Film-forming topical composition comprising at least two grades of hydroxypropylcellulose, at least one of which has a molecular weight of at least 800,000 and the other has a molecular weight of less than 400,000, at least a plasticizer, at least one organic solvent and at least one inorganic solvent, characterized in that: (a) Hydroxypropylcellulose having a molecular weight of at least 800,000 constitutes 0.2 to 4% by weight of the total weight of the composition, 10 (b) hydroxypropylcellulose having a molecular weight less than 400,000 represents 0.2 to 20% by weight of the total weight of the composition. (c) the plasticizer represents from 0.5 to 10% by weight of the total weight of the composition, (d) the inorganic solvent represents 10 to 60% by weight of the total weight of the composition, (e) the organic solvent represents 40 to 80% by weight of the total weight of the composition.

2. Composition according to claim 1, characterized in that hydroxypropylcellulose 20 having a molecular weight of at least 800,000 is present in a content of from 1 to 3% by weight, and hydroxypropylcellulose having a molecular weight less than 400,000 by weight is present in a content ranging from 2 to 6% by weight relative to the total weight of the composition.

3. Composition according to claim 1 or 2, characterized in that the plasticizer is chosen from among the glycols, notably glycerin.

4. Composition according to any one of the preceding claims, characterized in that the organic solvent represents 50 to 70% by weight of the total weight of the composition.

5. Composition according to any one of the preceding claims, characterized in that the inorganic solvent represents from 20 to 40% by weight of the total weight of the composition. 5.

6. Composition according to any one of the preceding claims, characterized in the organic solvent is chosen from liquid alcohols at room temperature such as ethanol, isopropanol, diacetone alcohol, 2-butoxyethanol, cyclohexanol and their mixtures, and preferably ethanol. 10.

7. Composition according to any one of the preceding claims, characterized in which includes pharmaceutically acceptable additives, such as perfumes, aromas, colorants, pigments, mattifying agents, rheological agents, preservatives, vitamins, essential oils, antibacterial agents, antiseptics, antivirals, antifungal agents, pain relievers, anti-inflammatories, healing agents, moisturizing agents, depigmenting agents, keratolytic agents, restructuring agents, anesthetics and sunscreens.

8. Composition according to claim 7, characterized in that it comprises as an additive a keratolytic agent, preferably salicylic acid in association with an active ingredient promoting healing, preferably tea tree essential oil.

9. Composition according to any one of the preceding claims, for use in a method of treating acne. 25 10. Composition according to any one of the preceding claims for its use in a cosmetic skin treatment method comprising at least one application of said composition to skin imperfections with a view to improving the appearance of the skin.