NEW ANTI-DANDRUFF FORMULAS

Abstract

The invention relates to cosmetic or dermatological compositions for combating dandruff which comprise water; at least 20% by weight of at least one polyol relative to the total weight of the composition; at least one anionic surfactant selected from acyl glutamic acids and their cosmetically acceptable salts, sodium lauryl sarcosinate, and disodium cocoglucoside citrate, and mixtures thereof; at least one non-ionic surfactant selected from alkyl glucosides; and at least one anti-dandruff agent which is piroctone olamine, said composition being devoid of ciclopiroxolamine and zinc pyrithione.

Description

Title of the invention: NEW ANTI-DANDRUFF COMPOSITIONS

[0001] The present invention relates to a new cosmetic or dermatological composition for combating dandruff.

[0002] Dandruff affects one in two people in France, its presence is benign, but it gives an unsightly appearance.

[0003] The scalp, like all skin, normally renews itself by shedding superficial epidermal cells. Dandruff consists of skin flakes, but unusually large, thicker, or more numerous than normal cells. Dandruff is classified as either dry or oily.

[0004] Dry dandruff is white, flat, and flakes off spontaneously. It is often accompanied by itching and is generally associated with a dry scalp.

[0005] Oily dandruff is smaller, round, yellowish, and greasy. It adheres to the scalp and hair. It is also accompanied by itching. Generally, it is a consequence of seborrhea and is often associated with an oily scalp and hair.

[0006] There are two dandruff conditions depending on the severity: - light dandruff consists of small whitish flakes corresponding to clumps of very volatile dead cells that fall from the scalp; - Seborrheic dermatitis involves dandruff associated with inflammation of the scalp, causing redness and itching.

[0007] The scalp epidermis is covered with a lipid film called sebum, the role of which is, among other things, to protect it from drying out. Malassezia is the name of a yeast belonging to the Fungi imperfecti group and is part of the commensal flora of humans. Several species are distinguished: M. furfur, M. sympodialis, M. globosa, M. restricta, and M. obtusa. Malassezia are lipophilic and keratinophilic yeasts; they are lipid-dependent. It is established that this fungus is a weak pathogen for humans. M. furfur is present in virtually the entire population. However, it is also established that M. furfur is responsible for dermatoses such as seborrheic dermatitis in approximately 3% of the population. Malassezia develops easily in oily environments, such as the scalp, where sebum is secreted in particularly high quantities, thus creating a favorable environment for its growth.

[0008] Not everyone secretes the same amount of sebum. Some people secrete a sufficient amount to promote the overgrowth of Malassezia and thus the formation of dandruff. Furthermore, the amount of sebum varies over time, particularly depending on hormonal secretions. Finally, other factors can contribute to the appearance of dandruff, such as stress, fatigue, pollution, lack of sunlight, certain illnesses, and certain medications, such as neuroleptics, etc.

[0009] Dandruff often appears during adolescence when sebum secretion begins. Men seem to be more frequently affected than women, probably due to the influence of androgen hormones.

[0010] Anti-dandruff compositions, particularly in the form of shampoos, have been known and commercially available for many years. They generally contain chemical active ingredients such as ketoconazole, zinc pyrithione, octopirox, ciclopirox olamine, salicylic acid, selenium sulfide, and azelaic acid. Some compounds, such as zinc pyrithione, are suspected of causing environmental problems, particularly ecotoxicity. It is therefore important to find new active ingredient compositions that are more environmentally friendly. Furthermore, speed of action is a major criterion for the consumer.

[0011] Furthermore, in recent years, consumers have become increasingly vigilant regarding the composition of the products they buy. A growing number of ingredients are being questioned, sometimes controversially, fueled by both mainstream and alternative media. It is therefore important to have streamlined formulas with, if possible, a limited number of ingredients; the challenge being to minimize the number of active ingredients in the formula while maintaining maximum efficacy.

[0012] There is therefore still a need for new dermo-cosmetic products to effectively combat dandruff and / or to prevent its formation.

[0013] Surprisingly, the inventors discovered that a particular combination of ingredients, including an anti-dandruff agent, Piroctone Olamine, and without zinc pyrithione or ciclopiroxolamine, exhibited very interesting fungicidal activity against Malassezia, and after only 5 minutes of application, which is a very important advantage compared to other anti-dandruff compositions tested.

[0014] According to a first aspect, the present invention proposes a cosmetic or dermatological composition, particularly suitable for topical application, especially on the skin (scalp) and hair. This composition comprises: - at least 35% by weight of water, relative to the total weight of the composition; - at least 20% by weight of at least one polyol, relative to the total weight of the composition; - at least one anionic surfactant selected from acyl glutamic acids and their cosmetically or dermatologically acceptable salts, sodium lauryl sarcosinate and disodium cocoglucoside citrate, and mixtures thereof; and - at least one non-ionic surfactant chosen from among the alkyl glucosides in which the alkyl radical preferentially comprises 8 to 16 carbon atoms; - at least one anti-dandruff agent which is piroctone olamine, the cosmetic or dermatological composition being free of ciclopiroxolamine and zinc pyrithione.

[0015] Definitions

[0016] By "approximately", it is understood, in this description, that the value concerned may be lower or higher by 10%, in particular by 5%, in particular by 1%, than the value indicated.

[0017] By "topical application" in the context of the present invention, we mean an application on the skin and hair, including of course the scalp and mucous membranes, preferably the scalp.

[0018] By "cosmetically or dermatologically acceptable", for the purposes of the present invention, means something that is useful in the preparation of a cosmetic or dermatological composition, that is generally safe, non-toxic and neither biologically nor otherwise undesirable and that is acceptable for cosmetic or dermatological use, in particular by topical application to the skin.

[0019] In the present description, "seborrheic dermatitis" means an inflammatory skin dermatosis that presents as red plaques covered with greasy, yellowish scales, more or less itchy, predominantly in areas rich in sebaceous glands.

[0020] In the present description, "at least one" means a single compound or a mixture of several such compounds.

[0021] According to the present invention, "free of" an ingredient means that the composition contains less than 0.01% by weight, preferably less than 0.001% by weight, of that ingredient, relative to the total weight of the composition, or, even more preferably, that it does not contain that ingredient.

[0022] According to particular embodiments of the present invention, the cosmetic or dermatological composition comprises at least 35% by weight of water relative to the total weight of the composition. Preferably, the composition according to the invention comprises at least 40% by weight of water relative to the total weight of the composition. Even more preferably, the composition according to the invention comprises at least 45% by weight of water relative to the total weight of the composition. According to particular embodiments of the present invention, the cosmetic or dermatological composition comprises less than 70% by weight of water relative to the total weight of the composition. Preferably, the composition according to the invention comprises less than 65% by weight of water, and preferably less than 60% by weight of water relative to the total weight of the composition.

[0023] Preferably, the composition according to the invention comprises 35 to 70% by weight of water, preferably 40 to 70% by weight of water, even more preferably 45 to 70% by weight of water, or even 35 to 65% by weight of water, or 35 to 60% by weight of water, relative to the total weight of the composition.

[0024] According to particular embodiments of the present invention, the cosmetic or dermatological composition comprises at least 20% by weight of at least one polyol relative to the total weight of the composition.

[0025] According to the present invention, "polyol" (also called polyalcohol) means a compound comprising a hydrocarbon chain with at least two carbon atoms and comprising at least two hydroxyl groups.

[0026] The polyol(s) used according to the invention may be natural or synthetic. They may have a linear, branched or cyclic molecular structure.

[0027] The polyol(s) used according to the invention can in particular be chosen from glycerin and its derivatives, and glycols and its derivatives. In particular, they can be chosen from the group consisting of glycerin, diglycerin, polyglycerin, diethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, pentylene glycol, hexylene glycol, 1,3-propanediol, 1,5-pentanediol, 1,2-hexanediol, octane 1,2-diol, polyethylene glycols, notably having 5 to 50 ethylene oxide groups, but also erythritol, threitol, arabitol, xylitol, ribitol, mannitol, sorbitol, galactitol, fucitol, iditol, inositol, volemitol, isomalt, maltitol, lactitol, maltotriitol, maltotetrol, polyglycitol, and mixtures thereof.

[0028] Preferably, at least one polyol, and preferably the only polyol, implemented according to the present invention is glycerin.

[0029] Preferably, the composition according to the invention comprises, as a polyol, glycerin which represents at least 75% by weight, preferably at least 80% by weight, and even more preferably at least 85% by weight, and even more preferably at least 90% by weight, of the total weight of the polyols in the composition according to the invention.

[0030] Preferably, the cosmetic or dermatological composition according to the invention comprises at least 25% by weight of at least one polyol, and even more preferably at least 30% by weight of at least one polyol, relative to the total weight of the composition.

[0031] According to the present invention, the anionic surfactant(s) is / are chosen from among acyl glutamic acids and their cosmetically or dermatologically approved salts acceptable are sodium lauryl sarcosinate, disodium cocoglucoside citrate and their mixtures.

[0032] Acylglutamic acids are preferably selected from those whose acyl group comprises a linear or branched, saturated or unsaturated hydrocarbon chain of 8 to 30 carbon atoms, preferably 10 to 20 carbon atoms, and most preferably 12 to 18 carbon atoms. The acyl group may, in particular, be selected from lauroyl, myristoyl, palmitoyl, stearoyl, olivoyl, cocoyl, and oleoyl groups. The cosmetically or dermatologically acceptable salt of acylglutamic acid may be selected from alkali metal salts, alkaline earth metal salts, and ammonium salts. For example, it may be selected from sodium, potassium, lithium, or magnesium salts, with sodium and potassium salts being particularly preferred in the context of the invention.

[0033] According to particular embodiments of the present invention, the anionic surfactant(s) selected from among acyl glutamic acids and their cosmetically or dermatologically acceptable salts may, for example, be chosen from the group consisting of compounds with the INCI names: sodium cocoyl glutamate, disodium cocoyl glutamate, sodium myristoyl glutamate, sodium lauroyl glutamate, potassium lauroyl glutamate, potassium cocoyl glutamate, and sodium stearoyl glutamate. Several anionic surfactants selected from among acyl glutamic acids and their cosmetically or dermatologically acceptable salts may be used in the composition according to the invention, which may, for example, contain any mixture of two or more of the compounds listed above.

[0034] Preferably, the composition according to the invention comprises a single anionic surfactant selected from acyl glutamic acids and their cosmetically or dermatologically acceptable salts. Even more preferably, the composition according to the invention comprises a single anionic surfactant, disodium cocoyl glutamate.

[0035] In advantageous embodiments, the composition according to the invention comprises a single anionic surfactant and a single non-ionic surfactant.

[0036] According to particular embodiments of the present invention, the non-ionic surfactant(s) selected from among the alkyl glucosides are preferably chosen from those whose alkyl radical comprises 8 to 16 carbon atoms. The alkyl glucosides are preferably chosen from the compounds with the INCI names: octyl glucoside, lauryl glucoside, and decyl glucoside.

[0037] According to particular embodiments of the present invention, the cosmetic or dermatological composition preferably comprises a single non-ionic surfactant, decyl glucoside.

[0038] According to particular embodiments of the present invention, the cosmetic or dermatological composition preferably comprises a single surfactant anionic, preferably disodium cocoyl glutamate, and a single non-ionic surfactant, preferably decyl glucoside.

[0039] According to particular embodiments of the present invention, the cosmetic or dermatological composition is free of amphoteric surfactant.

[0040] According to particular embodiments of the present invention, the cosmetic or dermatological composition is devoid of amphoteric surfactant amidopropyl betaines.

[0041] In the present invention, "amidopropyl betaines" means the following compounds: behenamidopropyl betaine, capryl / capramidopropyl betaine, cocamidopropyl betaine, isostearamidopropyl betaine, lauramidopropyl betaine, myristamidopropyl betaine, stearamidopropyl betaine, undecyleneamidopropyl betaine; as well as amidopropyl betaines derived from: almond, apricot, avocado, babas su, rapeseed, coconut oil, sunflower oil, oat, olive, palm oil, castor oil, soy, shea butter and wheat germ.

[0042] According to embodiments of the present invention, the cosmetic or dermatological composition is devoid of any surfactant of the type with isethionic acid or isethionate group, in particular of surfactant chosen from acyl isethionic acids or their salts, such as the substance with INCI name sodium cocoyl isethionate.

[0043] According to embodiments of the present invention, the cosmetic or dermatological composition is devoid of any surfactant of the type with a sulfosuccinic acid or sulfosuccinate group, in particular of a surfactant chosen from alkyl sulfosuccinic acids or their salts, such as the substance with the INCI name lauryl sulfosuccinate.

[0044] According to embodiments of the present invention, the cosmetic or dermatological composition is devoid of any surfactant comprising at least one sulfate group, i.e. an -O-SO3H or -O-SO2-O- group, such as laureth sulfate or lauryl sulfate.

[0045] In general, the cosmetic or dermatological composition according to the invention preferably contains the fewest possible surfactants. Thus, in particular embodiments of the invention, the cosmetic or dermatological composition according to the invention comprises no more than 5 surfactants, preferably no more than 4 surfactants, preferably still no more than 3 surfactants and preferably 2 surfactants.

[0046] In preferred embodiments of the invention, the total surfactant content is between 3 and 20% by weight, preferably between 5 and 15% by weight, preferably between 6 and 10% by weight, relative to the total weight of the composition.

[0047] The total content of said at least one anionic surfactant is preferably between 1 and 10% by weight, preferably between 2 and 6% by weight, relative to the total weight of the composition.

[0048] The total content of said at least one non-ionic surfactant is preferably between 1 and 10% by weight, preferably between 3 and 8% by weight, relative to the total weight of the composition.

[0049] The composition according to the invention may contain one or more gelling agent(s) selected from xanthan gum, scleroglucan gum, succinoglucan gum, gellan gum, diutan gum, acacia gum, Caesalpinia spinosa gum, carob gum, Tamarindus indica seed gum, or mixtures thereof.

[0050] Preferably, the gelling agent, when present, is xanthan gum.

[0051] The total content of gelling agent(s), when present, is preferably between 0.1 and 1% by weight, preferably between 0.2 and 0.8% by weight, preferably again between 0.4 and 0.6% by weight, relative to the total weight of the composition.

[0052] In particular embodiments of the present invention, the cosmetic or dermatological composition may contain one or more conditioning agents, in particular selected from guars, polyquatemiums, polyglyceryls, polysaccharides, squalane, etc.

[0053] Preferably, the conditioning agent, when present, is a guar.

[0054] According to preferred embodiments of the present invention, the total content of conditioning agent(s) when present is between 0.1 and 1% by weight relative to the total weight of the composition.

[0055] The composition according to the invention is also preferably free of silicone. For the purposes of the present invention, silicone, or polysiloxane, classically means any organosilicon polymer or oligomer with a linear and / or cyclic, branched and / or crosslinked structure, obtained by polymerization and / or polycondensation of functionalized silanes, and consisting essentially of a repetition of principal motifs in which the silicon atoms are linked together by oxygen atoms, hydrocarbon radicals, possibly substituted, in particular by hydroxyl groups, being directly linked by a carbon atom to these silicon atoms.

[0056] The composition according to the invention may contain one or more preservatives, or be free of them.

[0057] The composition according to the invention is preferably free of ingredients derived from Polyethylene glycol (PEG), which are derived from petrochemicals.

[0058] The composition according to the invention is also preferably free of phenoxyethanol, which is suspected of being an endocrine disruptor.

[0059] In particular embodiments of the invention, the composition is devoid of ethylenediaminetetraacetic acid (EDTA). Alternatively, it may contain such an acid.

[0060] In particular embodiments of the invention, the composition is devoid of essential oil. Indeed, most essential oils contain allergens, which can cause skin irritation and intolerance. Dyes with the same characteristics are preferably also avoided for similar reasons.

[0061] An important feature of the invention is that the composition according to the invention is devoid of zinc pyrithione and ciclopiroxolamine.

[0062] Piroctone olamine is an antifungal substance belonging to the hydroxypyridone family. This compound is often used in cosmetic products and in human medicine; for example, piroctone olamine is used at a maximum concentration of 1% (rinse-off products) or 0.05% to 0.1% (sufficient concentration in leave-on products). This compound has very low toxicity.

[0063] But piroctone olamine is only rarely used as the sole antifungal substance in anti-dandruff compositions; it is found associated with ciclopirox olamine and / or zinc pyrithione or even selenium and salicylic acid.

[0064] In the present invention, piroctone olamine is preferably the only antifungal agent from the hydroxy-pyridone family in the composition.

[0065] Advantageously, the composition according to the invention comprises from 0.01 to 1% by weight, preferably from 0.05 to 1% by weight, more preferably from 0.1 to 0.8% by weight, and even more preferably from 0.2 to 0.5% by weight of piroctone olamine relative to the total weight of the composition. Preferably, the composition according to the invention comprises 0.3% by weight of piroctone olamine relative to the total weight of the composition.

[0066] Advantageously, piroctone olamine is preferably the only anti-dandruff agent in the composition according to the present invention.

[0067] The composition according to the invention may further contain one or more ingredients such as menthyl lactate, menthol to obtain a cooling effect at the time of application to the scalp.

[0068] The invention preferably relates to compositions, in particular cosmetic or dermatological, presented in a form suitable for topically administration, in particular to the hair and / or scalp, preferably clean.

[0069] The cosmetic or dermatological compositions according to the invention may thus be presented in the forms which are usually known for a topical administration, i.e. including lotions, shampoos, dry shampoos, conditioners, balms, mousses, gels, dispersions, emulsions, sprays, serums, masks, creams, patches.

[0070] It is further distinguished between formulated products that can be rinsed and formulated products that do not require rinsing; rinsed products being more particularly suitable in the context of the present invention.

[0071] The absence of controversial agents in the cosmetic or dermatological composition according to the invention makes it possible to obtain compositions that are very well tolerated. To treat a scalp irritated by itching, it is important to choose hair care products that do not irritate the epidermis. Thus, silicone-free and sulfate-free compositions better respect the scalp's balance.

[0072] The compositions according to the invention are particularly interesting in the prevention and treatment of seborrheic dermatitis and / or for combating dandruff and / or preventing its formation, thanks to their immediate and lasting effectiveness.

[0073] The present invention also relates to the use, preferably topical, of a cosmetic or dermatological composition as defined above for the prevention and / or treatment of seborrheic dermatitis and / or to combat dandruff and / or prevent its formation.

[0074] Another object of the invention is a method of treatment and / or prevention of seborrheic dermatitis, comprising the administration, in particular by topical application to the scalp, of a composition according to the invention, as described above.

[0075] The present invention also relates to a non-therapeutic cosmetic treatment method for combating dandruff and / or preventing its formation, comprising the administration, particularly by topical application to the hair and / or scalp, of a cosmetic or dermatological composition according to the invention, as defined above. This composition preferably comprises a cosmetically or dermatologically acceptable excipient, more particularly acceptable for topical application.

[0076] The present invention also relates to a method for obtaining anti-dandruff efficacy on hair or scalp comprising the steps of: (i) wetting the hair with water; (ii) applying an effective amount of an anti-dandruff composition according to the present invention as described above to the hair; (iii) rinsing the anti-dandruff composition from the hair with water; and (iv) optionally repeating steps (ii) and (iii).

[0077] According to another aspect, the invention further relates to a method for achieving anti-seborrheic efficacy on the skin, comprising the steps of: (i) optionally wetting the skin with water; (ii) applying an effective amount of an anti-seborrheic composition according to the present invention as described above; (iii) rinse the anti-seborrheic composition from the skin with water; (iv) optionally repeat steps (ii) and (iii).

[0078] According to another aspect, the invention relates to the use of piroctone olamine as the sole anti-dandruff active agent in a cosmetic or dermatological composition according to the invention, as described above, particularly suitable for topical administration.

[0079] Thus, according to another aspect, the invention relates in particular to piroctone olamine, for its use as the sole anti-dandruff active agent, in a cosmetic or dermatological composition, in particular for topical administration, said composition comprising: - at least 35% by weight of water, relative to the total weight of the composition; - at least 20% by weight of at least one polyol, relative to the total weight of the composition; - at least one anionic surfactant selected from acyl glutamic acids and their cosmetically acceptable salts, sodium lauryl sarcosinate, disodium cocoglucoside citrate, and mixtures thereof; and - at least one non-ionic surfactant chosen from among the alkyl glucosides in which the alkyl radical comprises 8 to 16 carbon atoms; and allowing a 90% reduction in load after 5 minutes of contact with a population of Malas sezia furfur.

[0080] This use may correspond, with regard to the characteristics of the composition, to one or more of the above characteristics with reference to the cosmetic or dermatological composition according to the invention.

[0081] The features and advantages of the invention will become more apparent in the light of the following implementation example, provided by way of illustration only and in no way limiting the invention.

[0082] Example: Study of a composition according to the invention on an antimicrobial activity against Malassezia furfur

[0083] The aim is to compare the antimicrobial activity of a composition according to the invention to commercially available compositions known as anti-dandruff compositions.

[0084] The strain used is from the CBS-KNAW collection for M. furfur (Accession No.: CBS 1878).

[0085] This strain plays an important role in seborrheic dermatitis. Fungicidal activity against Malassezia furfur

[0086] The strain is incubated for 3 to 4 days at 30-35°C on modified Dixon agar under aerobic conditions.

[0087] Method used: dilution, neutralization and incorporation into agar plates: - inoculate 20g of the composition to be tested with 1% inoculum titrated to 107 CFU / ml; - leave in contact for the indicated time and after homogenization, take 1 g of the composition to be tested and make a 1 / 10 dilution in the neutralizer; - perform a second dilution to 1 / 10 in the neutralizer, the final dilution of the sample is 1 / 100; - leave in contact for 30 minutes ± 15 minutes; - perform a final dilution to 1 / 10th in the diluent; - incorporate 1 ml of these dilutions into the supercooled agar. Contact time: 5 minutes, 15 minutes and 60 minutes. Neutralizer: Tryptone soy broth (TSB) + 10% polysorbate 80. Diluent: tryptone salt.

[0088] The compositions tested are described below.

[0089] A / Composition A: composition according to the invention:

[0090] [Tables 1] Ingredients % (w / w) Water <70 Glycerin 25-30 Decyl glucoside 3-8 Disodium cocoyl glutamate 2-6 Xanthan gum 0.4-0.8 Sodium hydroxide <1 Guar hydroxypropyl <1 Piroctone olamine 0.3 Glyceryl laurate <1 Hexanediol caprylyl glycol 0.5-1 Fragrance <0.5

[0091] Table 1 - Composition A according to the invention

[0092] B / Composition 1: Anti-dandruff shampoo on the market: Water, sodium laureth sulfate, glycol distearate, coco-betaine, glycerin, dimethicone, selenium sulfide, carbomer, CI 47005 / acid yellow 3, citric acid, menthol, 2-oleamido-l,3-octadecanediol, PPG-5-cet-20, salicylic acid, sodium benzoate, sodium chloride, sodium hydroxide, tocopheryl acetate, parfum.

[0093] C / Composition 2: Anti-dandruff shampoo on the market: Eau, sodium laureth sulfate, sodium lauryl sulfate, sodium chloride, cocamidopropylbétaine, sodium xylenedulfonate, glycol distearate, sodium citrate, parfum, piroctone olamine, sodium benzoate, dimethiconol, citric acid, sodium salicylate, guar hydroxypropyltrimonium chloride, dimethicone, hexyl cinnamal, linalool tetrasodium EDTA, sodium hydroxide, TEA-dodecylbenzenesulfonate, trideceth-10, niacinamide, panthenol, tocopheryl acetate, benzyl alcohol, triethylene glycol, propylene glycol, CI 42090, CI 17200.

[0094] D / Composition 3 : Shampoing antipelliculaire sur le marché : Water, sodium cocoamphoacetate, lactamide MEA, ceteareth-60 myristyl glycol, disodium cocoyl glutamate, polysorbate-20, decyl glucoside, glycerin, PEG-120 methyl glucose dioleate, cocoglucoside, glyceryl oleate, citric acid, piroctone olamine, sodium benzoate, propylene glycol, trisodium ethylenediamine disuccinate, zinc gluconate, hydrogentaed vegetable glycerides citrate, tocopherol, helianthus annuus seed oil, benzyl alcohol, benzyl benzoate. Note that this composition 3 is bacteriostatic, meaning that it inhibits the multiplication of bacteria without killing them.

[0095] The results are summarized in Table 2 below.

[0096] [Tables2] Initial number of microorganisms (CFU / g) / % of microorganisms Number of microorganisms (CFU / g) / % of microorganisms remaining Contact time in minutes 5 15 60 Composition A 3.6 x 10⁴ 3.5 x 10³ 1.5 x 10³ 1.3 x 10³ 100% 10% 4% 3% Composition 1 2.0 x 10⁴ 1.3 x 10⁴ < 1.0 x 10² < 1.0 x 10² 100% 63% < 1% < 1% Composition 2 5.4 x 10⁴ 5.1 x 10⁴ 4.3 x 10⁴ 2.3 x 10⁴ 100% 94% 80% 42% Composition 3 1.5 x 10⁵ 1.3 x 10⁵ 1.3 x 10⁵ 1.3 x 105 100% 87% 87% 87%

[0097] Table 2 - Fungicidal activity against Malassezia furfur of the compositions

[0098] Comparative anti-dandruff compositions 1 and 2 induce a marked reduction in the number of microorganisms after 15 and 60 minutes of contact.

[0099] As expected, composition 3, which is bacteriostatic, does not induce a significant decrease in the number of microorganisms, the quantity of these microorganisms remaining stable throughout the study.

[0100] On the other hand, the composition according to the invention is the only one which acts effectively from 5 minutes of contact, indeed, only 10% of microorganisms are still present.

[0101] The composition according to the invention therefore presents a definite advantage, compared to the other compositions tested.

[0102] It is interesting to note that the comparative compositions contain less polyol than the composition according to the invention, and do not have the same surfactants (presence of amphoteric surfactants for all 3 compositions).

[0103] Thus, the inventors have developed an anti-dandruff composition, with immediate action with only one anti-dandruff agent and a relatively simple formula.

Claims

Demands

1. Cosmetic or dermatological composition comprising: - at least 35% by weight of water relative to the total weight of the composition; - at least 20% by weight of at least one polyol relative to the total weight of the composition; - at least one anionic surfactant selected from acyl glutamic acids and their cosmetically or dermatologically acceptable salts, sodium lauryl sarcosinate and disodium cocoglucoside citrate, and mixtures thereof; - at least one non-ionic surfactant selected from alkyl glucosides; - at least one anti-dandruff agent which is piroctone olamine, said composition being devoid of ciclopiroxolamine and zinc pyrithione.

2. Composition according to claim 1 characterized in that at least one anionic surfactant is selected from cosmetically or dermatologically acceptable acyl glutamic acids and their salts.

3. Composition according to claim 1 characterized in that the anionic surfactant is disodium cocoyl glutamate.

4. Composition according to any one of claims 1 to 3, characterized in that the non-ionic surfactant is decyl glucoside.

5. Composition according to any one of claims 1 to 4, characterized in that the composition is devoid of amphoteric surfactant.

6. Composition according to any one of claims 1 to 5, characterized in that at least one polyol is glycerin.

7. Composition according to any one of claims 1 to 6, characterized in that the composition comprises at least one gelling agent selected from xanthan gum, scleroglucan gum, succinoglucan gum, gellan gum, diutan gum, acacia gum, Caesalpinia spinosa gum, carob gum, Tamarindus indica seed gum, or mixtures thereof.

8. Composition according to claim 7, characterized in that the gelling agent is xanthan gum.

9. Composition according to any one of claims 1 to 8, characterized in that the composition is in a form suitable for topically administration.

10. Composition according to any one of claims 1 to 9, for its use in preventing and / or treating seborrheic dermatitis and / or in combating dandruff and / or preventing its formation.

11. Use of piroctone olamine as the sole anti-dandruff active agent in a dermatological composition as described in any one of claims 1 to 8, in particular suitable for topical administration.