Gene silencing of cardiovascular genes

Abstract

A bispecific nucleic acid molecule comprising at least two double stranded inhibitory ribonucleic acid (RNA) molecules that silence by RNA interference apolipoprotein B (ApoB) and diacylglycerol O acyltransferase 2 (DGAT2) wherein said at least two double stranded inhibitory RNA molecules are linked by a DNA linker molecule that has a melting temperature (TM) of approximately 73oC. The use of such dual siRNA constructs in treating cardiovascular related conditions including hypercholesterolemia is further claimed. [Fig. 2A]