Leave-on liquid bactericide composition

Abstract

To provide a leave-on liquid bactericide composition that contains bactericides other than monoalcohols with five or fewer carbon atoms, particularly outstanding in skin sanitizing properties and its prolonged effect, and offers rapid drying.SOLUTION: A leave-on liquid bactericide composition contains component (A): a polyol with an OH group to C atom ratio of 0.45 or less, component (B): bactericides other than component (A) and monoalcohols with five or fewer carbon atoms, and component (C): carboxylic acid or a salt thereof. In the composition, the content of component (A) is 0.2 mass% or more and 30 mass% or less, the content of component (B) is 0.01 mass% or more and 10 mass% or less, and the content of component (C) is 0.01 mass% or more and 15 mass% or less. In the composition, the mass ratio of trivalent metal ions to the component (A) (trivalent metal ion / component (A)) is 0.2 or less. The pH at 25°C is 3.5 or more and 7.0 or less.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a leave-on liquid fungicide composition. [Background technology]

[0002] According to recent surveys, it is now known that contact infection is the most common route of bacterial or viral infection in people's daily lives. Contact infection occurs mainly when hands come into contact with infected people, doorknobs, handles, tableware, toys, other daily necessities, interior items, etc.

[0003] There is a demand for methods to prevent such bacterial or viral infections caused by contact behavior in daily life. As a method for preventing contact infection of bacteria or viruses through hands, a method of applying a monoalcohol having 5 or less carbon atoms such as ethanol to hands to sterilize and disinfect them is known. However, monoalcohols having 5 or less carbon atoms such as ethanol, which are used as sterilizing or disinfecting components, are highly volatile and difficult to remain on the skin surface for a long time, so that the durability of the sterilizing performance is insufficient.

[0004] Therefore, topical skin preparations containing bactericidal ingredients other than ethanol are being investigated. For example, Patent Document 1 discloses that a long-lasting bactericidal disinfectant cream contains a cationic bactericidal disinfectant, a lower alcohol, an oily base, a higher aliphatic alcohol, a lipophilic and hydrophilic nonionic surfactant, a water-soluble polyhydric alcohol, and purified water, and has both a long-lasting disinfecting effect on the skin, hands, and traumatic wounds and an effect of preventing rough hands. Patent Document 2 discloses a compound or composition that can suppress bacteria and viruses present on the skin surface of a mammal and reduce the skin pH to less than about 4, and describes that the compound or composition further contains an antimicrobial agent selected from the group consisting of phenolic antibacterial agents, quaternary ammonium antimicrobial agents, anilides, bisguanidines, and mixtures thereof. Patent Document 3 discloses a preservative composition comprising synergistically effective amounts of one or more plant ingredients, benzyl alcohol, and 1,3-propanediol, in which the plant ingredients and the benzyl alcohol are present in a specific ratio and the pH of the composition is in the range of 3 to 5, and a personal care product comprising the preservative composition.

[0005] Wet sheets containing a bactericidal component other than ethanol are also known. Patent Document 4 discloses that a wet sheet is formed by impregnating a liquid agent into a base sheet made of a fiber material, and the liquid agent contains lactic acid, citric acid, malic acid, acetic acid, or a salt of these acids, or a combination of two or more selected from these acids and salts, a quaternary ammonium salt surfactant, and water, but does not contain ethanol, and has a specific pH range, and yet has low irritation to the skin despite having a high bactericidal and antibacterial effect. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] JP 2007-284412 A [Patent Document 2] Special Publication No. 2008-523064 [Patent Document 3] Special Publication No. 2012-532141 [Patent Document 4] JP 2020-199090 A Summary of the Invention [Problem to be solved by the invention]

[0007] However, according to the study by the present inventors, it has been found that the cationic bactericides used in the above-mentioned patent documents are less effective at killing bacteria on the surface of human skin than inorganic materials such as stainless steel and glass. In addition, the amount of cationic bactericides that can be incorporated into compositions for skin is sometimes substantially limited from the viewpoints of skin irritation, safety to the human body, etc. Therefore, it has been found that the cationic bactericides in the prior art do not provide sufficient bactericidal activity and sustained effect on the skin. In addition, in practical use, a leave-on liquid composition is also required to dry quickly after application to an object, although the above-mentioned patent document does not mention this point.

[0008] The present invention relates to a leave-on liquid disinfectant composition which contains a disinfectant other than a monoalcohol having 5 or less carbon atoms, has excellent disinfecting properties, particularly on the skin, and has a sustained disinfecting effect, and dries quickly. [Means for solving the problem]

[0009] The inventors have found that a leave-on liquid disinfectant composition containing specific amounts of a specific polyol, a disinfectant other than a monoalcohol having 5 or less carbon atoms, and a carboxylic acid or a salt thereof, and having a mass ratio of trivalent metal ions to the polyol and a pH within a specified range, can achieve the above-mentioned effects. That is, the present invention provides: Component (A): a polyol having a number of OH groups / number of C atoms of 0.45 or less; Component (B): A disinfectant other than component (A) and monoalcohols having 5 or less carbon atoms, and Component (C): Carboxylic acid or its salt A leave-on liquid fungicide composition comprising: The leave-on liquid fungicide composition has a content of component (A) in the composition of 0.2 to 30% by mass, a content of component (B) in the composition of 0.01 to 10% by mass, a content of component (C) in the composition of 0.01 to 15% by mass, a mass ratio of trivalent metal ions to component (A) in the composition (trivalent metal ions / component (A)) of 0.20 or less, and a pH at 25°C of 3.5 to 7.0. Effect of the Invention

[0010] According to the present invention, it is possible to provide a leave-on liquid disinfectant composition which contains a disinfectant other than a monoalcohol having 5 or less carbon atoms, has excellent disinfecting properties particularly on the skin and its sustained effect, and dries quickly. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] [Definition] As used herein, the term "leave-on fungicide composition" refers to a fungicide composition which, after application to an object, is left on the surface of the object without being removed by rinsing with water or the like. In this specification, the term "liquid" means one that has fluidity at 25°C, and preferably one whose viscosity at 25°C is in the range described below.

[0012] [Leave-on liquid fungicide composition] The leave-on liquid fungicide composition of the present invention (hereinafter also simply referred to as "the composition (of the present invention)") is Component (A): a polyol having a number of OH groups / number of C atoms of 0.45 or less; Component (B): A disinfectant other than component (A) and monoalcohols having 5 or less carbon atoms, and Component (C): Carboxylic acid or its salt A leave-on liquid fungicide composition comprising: The content of component (A) in the composition is 0.2% by mass or more and 30% by mass or less, the content of component (B) in the composition is 0.01% by mass or more and 10% by mass or less, the content of component (C) in the composition is 0.01% by mass or more and 15% by mass or less, the mass ratio of trivalent metal ions to component (A) in the composition (trivalent metal ions / component (A)) is 0.20 or less, and the pH at 25°C is 3.5 or more and 7.0 or less. By virtue of having the above-mentioned constitution, the composition of the present invention becomes a leave-on liquid germicidal composition which is particularly excellent in bactericidal activity on the skin and has a sustained bactericidal effect, and dries quickly.

[0013] The reason why the composition of the present invention exhibits the above-mentioned effects is not clear, but is thought to be as follows. As described above, the present inventors have found that it is difficult to obtain a bactericidal effect on the surface of human skin with a bactericide other than component (A) and a monoalcohol having 5 or less carbon atoms, which is component (B). This is thought to be due to the interaction between the bactericide and the skin, which causes the bactericide to be adsorbed to the skin, resulting in a decrease in bactericidal activity on the surface of human skin.

[0014] On the other hand, in the composition of the present invention, the polyol, which is component (A), acts as a bactericidal component and is also thought to have the function of suppressing a decrease in the bactericidal activity of component (B). The polyol, which is component (A), has a hydrophilic hydroxyl group and a hydrophobic portion containing carbon atoms, and it is believed that the hydrophobic portion distorts or destroys the three-dimensional hydrogen bond network of water, thereby changing the water environment around bacteria, and denaturing, for example, hydrophilic membrane proteins of bacteria. Component (A) is considered to have excellent bactericidal properties due to the above-mentioned action, since the number of OH groups / number of C atoms is 0.45 or less. In addition, component (A) is less volatile than monoalcohols with 5 or less carbon atoms, such as ethanol, and can remain near the skin surface at a high concentration for a long time after application to the skin. It also acts as a solvent for component (B) on the skin surface, suppressing the adsorption of component (B) to the skin surface and suppressing the decrease in the bactericidal activity on the skin, which is thought to improve the bactericidal properties and their sustained effect.

[0015] Component (C) is used primarily for the purpose of adjusting the pH of the composition of the present invention to a range of 3.5 to 7.0 in order to stabilize the pH of the composition of the present invention, ensure bactericidal properties, and inhibit skin irritation. Component (C) is at least partially ionized in the composition, and the selection of the counter cation, which is the counter ion, affects the bactericidal properties and drying speed of the composition of the present invention. Specifically, when the mass ratio of trivalent metal ions to component (A) in the composition of the present invention (trivalent metal ions / component (A)) exceeds a certain value, both the bactericidal properties on skin and the drying speed of the composition tend to decrease. The reason for this is thought to be that when the counter cation of component (C) is a trivalent metal ion, the trivalent metal ion is adsorbed to bacteria before component (B), making it difficult for component (B) to be adsorbed to bacteria, thereby inhibiting the bactericidal properties and their sustained effect of the composition. The decrease in the drying speed is thought to be due to the fact that trivalent metal ions have a large valence and a large charge density on the ion surface, and therefore the amount of hydrated water bound by the ions increases, which slows down the evaporation of water in the composition.

[0016] For the above reasons, it is believed that the composition of the present invention, which contains the above-mentioned components (A) to (C) in respective predetermined amounts, has a mass ratio of trivalent metal ions to component (A) (trivalent metal ions / component (A)) that is equal to or less than a predetermined value, and has a pH at 25°C within a predetermined range, is particularly excellent in terms of bactericidal activity on the skin and its sustained effect, and also has an improved drying speed.

[0017] From the viewpoint of the usefulness of the present invention, the subject to which the composition of the present invention is applied is preferably the skin, more preferably the skin excluding the scalp. That is, the composition of the present invention is preferably a leave-on liquid fungicide composition for the skin. From the viewpoint of high usefulness of the present invention, the composition of the present invention is more preferably a leave-on liquid disinfectant composition for hands.

[0018] The bacteria against which the composition of the present invention exerts its bactericidal properties are not particularly limited, so long as they are inactivated or killed by contact with the composition. For example, microorganisms listed in the Ministry of Health, Labor and Welfare's guidelines for infectious disease control in daycare centers can be applied. Specific examples of bacteria include gram-positive bacteria such as Bacillus anthracis, Mycobacterium tuberculosis, Streptococcus pyogenes, Staphylococcus aureus, and Streptococcus pneumoniae, and gram-negative bacteria such as Serratia marcescens, Francisella tularensis, Yersinia pestis, Brucella, Bacillus mallei, Vibrio cholerae, Salmonella, Shigella, Escherichia coli, and Bordetella pertussis. In this example, the bactericidal activity is evaluated using Serratia marcescens as an example, but the bacteria that can be disinfected by the composition of the present invention are not limited to this.

[0019] The composition of the present invention can also be used as a disinfectant composition against not only bacteria but also viruses, such as enveloped viruses arenavirus, Ebola virus, smallpox virus, Nairo virus, Marburg virus, coronavirus, monkeypox virus, betacoronavirus, influenza virus, RS virus, herpes virus, mumps virus, varicella-zoster virus, rubella virus, and measles virus, and non-enveloped viruses such as enterovirus, adenovirus, coxsackievirus, norovirus, and rotavirus.

[0020] <Component (A): Polyol with OH group number / C atom number of 0.45 or less> The polyol used as component (A) is a polyol having a ratio of the number of OH groups / the number of C atoms of 0.45 or less. The number of OH groups / number of C atoms of component (A) is 0.45 or less, preferably 0.40 or less, more preferably 0.35 or less, from the viewpoint of improving bactericidal activity and its sustained effect, and from the viewpoint of improving drying speed. Also, from the viewpoint of improving bactericidal activity and its sustained effect, it is preferably 0.10 or more, more preferably 0.15 or more, and even more preferably 0.17 or more. Also, from the viewpoint of improving the low temperature stability of the composition of the present invention, it is preferably 0.20 or more, more preferably 0.25 or more, even more preferably 0.27 or more, and even more preferably 0.30 or more.

[0021] From the viewpoint of improving the bactericidal activity and its sustained effect, and from the viewpoint of improving the drying speed, the component (A) is preferably a low molecular weight compound. Specifically, the molecular weight of the component (A) is preferably 1,000 or less, more preferably 800 or less, even more preferably 500 or less, even more preferably 300 or less, even more preferably 250 or less, even more preferably 200 or less, and even more preferably 150 or less. In addition, from the viewpoint of suppressing the volatilization of the component (A) to improve the sustained effect of the bactericidal activity, and from the viewpoint of improving the drying speed, the molecular weight is preferably 80 or more, more preferably 100 or more.

[0022] The number of C atoms in component (A) is 5 or more, preferably 6 or more, from the viewpoint of improving bactericidal activity and its sustained effect, and is preferably 24 or less, more preferably 20 or less, even more preferably 16 or less, still more preferably 12 or less, and still more preferably 11 or less, from the viewpoint of improving bactericidal activity and its sustained effect and from the viewpoint of improving the drying speed. In addition, from the viewpoint of improving the bactericidal activity and its sustained effect, and from the viewpoint of improving the drying speed, the number of OH groups in component (A) is preferably 2 or more and 5 or less, more preferably 2 or more and 4 or less, even more preferably 2 or more and 3 or less, and even more preferably 2.

[0023] Specific examples of component (A) include linear polyols and polyols having a cyclic structure, and any of these can be used. Component (A) is preferably a linear polyol from the viewpoint of exerting bactericidal properties by distorting or destroying the three-dimensional hydrogen bond network of the water surrounding the bacteria by the hydrophobic portion, thereby making it impossible for the bacteria to exist stably, and is more preferably a linear diol or a linear triol, and even more preferably a linear diol, from the viewpoint of improving bactericidal properties and its sustained effect by having a hydrophobic portion. In the linear polyol, the bonding position of the OH group is not particularly limited.

[0024] Examples of the linear polyol contained as component (A) include linear diols such as dipropylene glycol, tripropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 2,5-hexanediol, 1,6-hexanediol, 1,2-heptanediol, 1,7-heptanediol, 1,2-octanediol, 1,8-octanediol, 1,2-nonanediol, 1,9-nonanediol, 1,2-decanediol, 1,10-decanediol, 1,2-dodecanediol, 1,12-dodecanediol, 1,2-tetradecanediol, 1,2-hexadecanediol, and 1,16-hexadecanediol; Linear triols such as 1,2,7-heptanetriol, 1,2,8-octanetriol, 1,2,9-nonanetriol, and 1,2,10-decanetriol; Branched diols or triols such as 2,2-dimethyl-1,3-propanediol, 3-methyl-1,3-butanediol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 3-(2-ethylhexyloxy)-1,2-propanediol, (lauryl / myristyl) glycol hydroxypropyl ether, 3,7,11,15-tetramethylhexadecane-1,2,3-triol; and and polymers such as polyethylene glycol; and the like. One or more of these may be contained. From the viewpoint of improving the bactericidal activity and its sustained effect, the content of the chain polyol in component (A) is preferably 80% by mass or more, more preferably 90% by mass or more, and most preferably 100% by mass.

[0025] Among the above, from the viewpoint of improving the bactericidal activity and its sustained effect, and from the viewpoint of improving the drying speed, the component (A) is preferably dipropylene glycol, tripropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, 1,2-octanediol, 1,8-octanediol, 1,2-nonanediol, 1,9-nonanediol, 1,2-decanediol, 1,10-decanediol, 1,2-dodecanediol, 1,12-dodecanediol, 1,2,10-decanetriol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, 3-(2-ethylhexyloxy)-1,2-propanediol, and polyethylene glycol, more preferably one or more selected from the group consisting of dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol, and even more preferably one or more selected from the group consisting of dipropylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol. Further, from the viewpoint of less stickiness after drying when the composition is applied to the skin, one or more selected from the group consisting of dipropylene glycol and 3-(2-ethylhexyloxy)-1,2-propanediol are even more preferred. Furthermore, from the viewpoint of low temperature stability of the composition of the present invention, dipropylene glycol is even more preferred.

[0026] <Component (B): Bactericide other than component (A) and monoalcohols with 5 or less carbon atoms> Component (B) is a bactericide other than component (A) and monoalcohols having 5 or less carbon atoms. Suitable component (B) includes at least one selected from the group consisting of cationic bactericides, iodine bactericides, phenol bactericides, biguanide bactericides, terpenoid bactericides, chlorine bactericides, and amphoteric surfactant bactericides. These bactericides are particularly suitable for use in skin topical compositions.

[0027] Examples of cationic disinfectants include cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, alkyltrimethylammonium chloride, and dialkyldimethylammonium chloride. Examples of iodine-based disinfectants include povidone iodine, polyvinyl alcohol iodine, and cyclodextrin iodine. Phenol-based disinfectants include isopropylmethylphenol, triclosan, and phenoxyethanol. Biguanide disinfectants include chlorhexidine gluconate. Terpenoid fungicides include dipotassium glycyrrhizinate, stearyl glycyrrhetinate, and β-glycyrrhetinic acid. Examples of chlorine-based disinfectants include hypochlorous acid, sodium hypochlorite, calcium hypochlorite, and chlorinated isocyanuric acid. Examples of amphoteric surfactant-based bactericides include alkyldiaminoethylglycine hydrochloride and alkylpolyaminoethylglycine.

[0028] The component (B) can be used alone or in combination of two or more. Among the above, from the viewpoint of improving bactericidal properties and their sustained effect, component (B) is preferably one or more selected from the group consisting of cationic bactericides, iodine bactericides, phenol bactericides, and biguanide bactericides, more preferably one or more selected from the group consisting of cationic bactericides and biguanide bactericides, even more preferably one or more selected from the group consisting of benzethonium chloride, benzalkonium chloride, and chlorhexidine gluconate, and even more preferably benzalkonium chloride. When component (B) is benzalkonium chloride, from the viewpoint of improving bactericidal activity, the number of carbon atoms in the alkyl group is preferably 6 or more, more preferably 8 or more, more preferably 10 or more, even more preferably 12 or more, and preferably 20 or less, more preferably 18 or less, even more preferably 16 or less. When component (B) is an alkyltrimethylammonium chloride, from the viewpoint of improving the bactericidal activity, the number of carbon atoms in the alkyl group is preferably 6 or more, more preferably 8 or more, even more preferably 10 or more, and is preferably 24 or less, more preferably 22 or less, even more preferably 15 or less. When component (B) is a dialkyldimethylammonium chloride, from the viewpoint of improving the bactericidal activity, the number of carbon atoms in the alkyl group is preferably 6 or more, more preferably 8 or more, even more preferably 10 or more, and is preferably 20 or less, more preferably 18 or less.

[0029] <Component (C): Carboxylic acid or its salt> As the carboxylic acid in component (C), those used in external skin preparation compositions are preferred. Examples of the carboxylic acid include hydroxycarboxylic acids such as lactic acid, citric acid, malic acid, tartaric acid, glycolic acid, glyceric acid, gluconic acid, and salicylic acid; aliphatic carboxylic acids such as formic acid, acetic acid, propionic acid, malonic acid, succinic acid, glutaric acid, adipic acid, maleic acid, fumaric acid, and sorbic acid; aromatic carboxylic acids such as benzoic acid, phthalic acid, and isophthalic acid; and other carboxylic acids such as pyruvic acid, urocanic acid, and polyglutamic acid. One or more of these may be used. Among the above, from the viewpoints of improving the bactericidal properties, adjusting the pH of the composition to a desired range, and suppressing skin irritation, the carboxylic acid in component (C) is preferably one or more selected from the group consisting of lactic acid, citric acid, malic acid, tartaric acid, gluconic acid, formic acid, acetic acid, succinic acid, adipic acid, sorbic acid, and benzoic acid, more preferably one or more selected from the group consisting of lactic acid, citric acid, malic acid, and succinic acid, and even more preferably lactic acid.

[0030] The carboxylic acid salt in component (C) is preferably a monovalent or divalent metal salt of a carboxylic acid, more preferably an alkali metal salt or an alkaline earth metal salt of a carboxylic acid, from the viewpoint of improving the bactericidal activity and its sustained effect, and from the viewpoint of improving the drying speed. And, from the viewpoint of the absence of squeaking during the drying process of the composition and the viewpoint of improving the moist feeling after drying, it is still more preferably a monovalent metal salt of a carboxylic acid, even more preferably an alkali metal salt of a carboxylic acid, even more preferably one or more selected from the group consisting of sodium salts and potassium salts of a carboxylic acid, and even more preferably a sodium salt of a carboxylic acid.

[0031] That is, component (C) is preferably one or more selected from the group consisting of lactic acid, citric acid, malic acid, tartaric acid, gluconic acid, formic acid, acetic acid, succinic acid, adipic acid, sorbic acid, benzoic acid, and salts thereof, more preferably one or more selected from the group consisting of lactic acid, citric acid, malic acid, succinic acid, and salts thereof, even more preferably lactic acid or a salt thereof, even more preferably one or more selected from the group consisting of lactic acid and sodium lactate, and even more preferably an embodiment containing lactic acid. When component (C) contains lactic acid, the content of lactic acid in the total amount of component (C) is preferably 50 mass% or more, more preferably 70 mass% or more, even more preferably 80 mass% or more, and even more preferably 90 mass% or more and 100 mass% or less.

[0032] <Content> The content of component (A) in the composition is 0.2% by mass or more, preferably 0.3% by mass or more, more preferably 0.5% by mass or more, even more preferably 1.0% by mass or more, even more preferably 1.5% by mass or more, even more preferably 2.0% by mass or more, from the viewpoint of improving the drying speed, reducing stickiness after drying, and from the viewpoint of economy, it is 30% by mass or less, preferably 20% by mass or less, more preferably 15% by mass or less, even more preferably 10% by mass or less, even more preferably 5.0% by mass or less, even more preferably 4.0% by mass or less, even more preferably 3.5% by mass or less.

[0033] The content of component (B) in the composition is 0.01% by mass or more, preferably 0.02% by mass or more, more preferably 0.03% by mass or more, from the viewpoint of improving the bactericidal activity and its sustained effect. Also, from the viewpoint of safety to the human body, compatibility with the skin during the drying process of the composition, and less stickiness after drying, the content is 10% by mass or less, preferably 5.0% by mass or less, more preferably 2.0% by mass or less, even more preferably 1.0% by mass or less, still more preferably 0.5% by mass or less, and even more preferably 0.1% by mass or less.

[0034] The total content of component (A) and component (B) in the composition is 0.21% by mass or more, preferably 0.25% by mass or more, more preferably 0.30% by mass or more, even more preferably 0.50% by mass or more, even more preferably 1.0% by mass or more, and even more preferably 2.0% by mass or more, from the viewpoint of improving the drying speed, reducing stickiness after drying, and suppressing skin irritation, it is preferably 35% by mass or less, more preferably 30% by mass or less, even more preferably 20% by mass or less, even more preferably 10% by mass or less, even more preferably 5.0% by mass or less, even more preferably 3.5% by mass or less, and even more preferably 3.2% by mass or less.

[0035] The content of component (C) in the composition is 0.01% by mass or more, preferably 0.02% by mass or more, more preferably 0.03% by mass or more, and even more preferably 0.05% by mass or more, from the viewpoint of improving the bactericidal property and adjusting the pH of the composition to a desired range. Also, from the viewpoint of adjusting the pH of the composition to a desired range, improving the drying speed, and suppressing skin irritation, it is 15% by mass or less, preferably 10% by mass or less, more preferably 5.0% by mass or less, even more preferably 3.0% by mass or less, even more preferably 2.0% by mass or less, and even more preferably 1.0% by mass or less. In this specification, when a carboxylic acid salt is used as component (C), the content of component (C) is the amount calculated as carboxylic acid.

[0036] The total content of components (A) to (C) in the composition is preferably 0.25% by mass or more, more preferably 0.30% by mass or more, even more preferably 0.50% by mass or more, still more preferably 1.0% by mass or more, still more preferably 2.0% by mass or more, and still more preferably 2.1% by mass or more, from the viewpoints of improving the drying speed, reducing stickiness after drying, and suppressing skin irritation, it is preferably 40% by mass or less, more preferably 30% by mass or less, even more preferably 20% by mass or less, still more preferably 10% by mass or less, still more preferably 5.0% by mass or less, and still more preferably 3.5% by mass or less.

[0037] <Trivalent metal ions> The mass ratio of trivalent metal ion to component (A) in the composition of the present invention (trivalent metal ion / component (A)) is, from the viewpoints of improving bactericidal activity and its sustained effect, improving the drying speed, eliminating squeaking during the drying process, and improving the moist feeling after drying, 0.20 or less, preferably 0.15 or less, more preferably 0.10 or less, even more preferably 0.05 or less, still more preferably 0.02 or less, still more preferably 0.01 or less, still more preferably 0.005 or less, and still more preferably 0. The trivalent metal ion referred to here is Al. 3+ Ion, Fe 3+ The source of the trivalent metal ion is not particularly limited, and may be a metal ion derived from the carboxylate salt, which is component (C), or may be a metal ion derived from another component.

[0038] The content of trivalent metal ions in the composition is preferably 0.20% by mass or less, more preferably 0.15% by mass or less, even more preferably 0.10% by mass or less, still more preferably 0.05% by mass or less, still more preferably 0.02% by mass or less, still more preferably 0.01% by mass or less, still more preferably 0.005% by mass or less, and still more preferably 0% by mass, from the standpoints of improving bactericidal activity and its sustained effect, improving the drying speed, eliminating squeaking during the drying process, and improving the moist feeling after drying. The content of trivalent metal ions in the composition can be measured by inductively coupled plasma atomic emission spectrometry (ICP-AES) under the following conditions. <icp-aes> (Equipment used) Thermo Fisher Scientific "iCAP 6500Duo" (Measurement conditions) RF power: 1150W, auxiliary gas flow rate: 0.5L / min, nebulizer gas flow rate: 0.7L / min, coolant gas flow rate: 12L / min When performing ICP-AES measurements, the measurement sample is first pretreated using the dry ashing method. The sample is placed in a quartz crucible and heated to ashing. Ashing is performed at 550°C using an electric furnace. The ashed sample is then dissolved in hydrochloric acid, nitric acid, or sulfuric acid, and the ICP-AES measurement is performed. Furthermore, the content of trivalent metal ions in the composition can be determined by calculation when the blending amount of the metal ions or the components that serve as the supply sources of the metal ions is known.

[0039] <Monovalent or divalent metal ions> The composition of the present invention preferably contains a monovalent or divalent metal ion, more preferably a monovalent metal ion, from the viewpoints of preventing squeaking during the drying process and improving the moist feeling after drying without reducing the bactericidal activity and its sustained effect. The metal ion is preferably at least one selected from the group consisting of alkali metal ions and alkaline earth metal ions, more preferably an alkali metal ion, further preferably at least one selected from the group consisting of sodium ions and potassium ions, and even more preferably a sodium ion. The source of the monovalent or divalent metal ion is not particularly limited, and may be a metal ion derived from the carboxylate salt, which is component (C), or a metal ion derived from another component.

[0040] The content of monovalent or divalent metal ions in the composition is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, and even more preferably 0.01% by mass or more, from the viewpoint of improving the absence of squeaking during the drying process and the moist feeling after drying without reducing the bactericidal activity and its sustained effect, and is preferably 0.50% by mass or less, more preferably 0.20% by mass or less, even more preferably 0.10% by mass or less, and even more preferably 0.05% by mass or less, from the viewpoint of improving the drying speed, the absence of squeaking during the drying process, and the moist feeling after drying. The content of monovalent or divalent metal ions in the composition can be determined in the same manner as the content of trivalent metal ions.

[0041] <Component (D): Polyol with number of OH groups / number of C atoms exceeding 0.45> From the viewpoint of ease of spreading on the skin and improving compatibility with the skin during the drying process, the composition of the present invention may further contain component (D): a polyol having the number of OH groups / number of C atoms of more than 0.45, within a range that does not impair the effects of the present invention. The number of OH groups / number of C atoms of component (D) is more than 0.45, and preferably 0.50 or more, and from the viewpoints of achieving bactericidal activity and its sustained effect, as well as suppressing a decrease in the drying rate, is preferably 2.0 or less, more preferably 1.8 or less, even more preferably 1.5 or less, and still more preferably 1.2 or less.

[0042] From the viewpoint of suppressing the decrease in the bactericidal activity and its sustained effect, and the drying speed, it is preferable that the component (D) is a low molecular weight compound. Specifically, the molecular weight of the component (D) is preferably 1,000 or less, more preferably 800 or less, even more preferably 500 or less, even more preferably 200 or less, and even more preferably 150 or less. In addition, from the viewpoint of suppressing the volatilization of the component (D), it is preferably 80 or more, more preferably 90 or more.

[0043] The number of C atoms in component (D) is preferably 3 or more, and from the viewpoints of bactericidal activity and its sustained effect, as well as suppressing a decrease in the drying rate, availability, and improving the low-temperature stability of the composition, it is preferably 24 or less, more preferably 18 or less, even more preferably 12 or less, still more preferably 8 or less, and still more preferably 6 or less. The number of OH groups in component (D) is preferably 2 or more and 6 or less, more preferably 2 or more and 5 or less, and even more preferably 2 or more and 4 or less, from the viewpoints of bactericidal activity and its sustained effect, suppressing a decrease in the drying rate, and ease of compatibility with the skin during the drying process.

[0044] Component (D) may be a chain polyol or a polyol having a cyclic structure, and from the viewpoints of ease of spreading on the skin, ease of compatibility with the skin during drying, and availability, a chain polyol is preferred. In the chain polyol, the bonding position of the OH group is not particularly limited. Examples of polyols used as component (D) include linear diols such as propylene glycol (1,2-propanediol), 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, and 2,3-butanediol; linear triols such as glycerol, 1,2,3-butanetriol, 1,2,4-butanetriol, 1,2,5-pentanetriol, and 1,2,6-hexanetriol; branched polyols such as 2-methyl-1,3-propanediol; sugar alcohols such as sorbitol; and polyglycerin. One or more of these may be used. Among the above, from the viewpoints of bactericidal activity and its sustained effect, suppressing a decrease in the drying rate, improving the low-temperature stability of the composition, and availability, component (D) is preferably one or more selected from the group consisting of propylene glycol (1,2-propanediol), 1,3-butylene glycol, glycerol, and sorbitol, and more preferably glycerol.

[0045] When the composition of the present invention contains component (D), the content of component (D) in the composition is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.5% by mass or more, still more preferably 1.0% by mass or more, and even more preferably 2.0% by mass or more from the viewpoint of improving the bactericidal activity and its sustained effect, and suppressing the decrease in the drying speed, it is preferably 5.0% by mass or less, more preferably 3.0% by mass or less.

[0046] In addition, the mass ratio of the content of component (D) to the content of component (A) in the composition (component (D) / component (A)) is, from the viewpoints of bactericidal activity and its sustained effect, and suppressing a decrease in the drying rate, preferably 0.003 or more, more preferably 0.01 or more, even more preferably 0.025 or more, still more preferably 0.05 or more, still more preferably 0.1 or more, still more preferably 0.5 or more, and is preferably 25 or less, more preferably 10 or less, still more preferably 5.0 or less, and still more preferably 2.0 or less. Furthermore, from the viewpoint of improving bactericidal activity and its sustained effect, the content of the linear polyol in component (D) is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, even more preferably 80% by mass or more, still more preferably 90% by mass or more, and most preferably 100% by mass.

[0047] <Component (E): Nonionic surfactant> The composition of the present invention may further contain component (E): a nonionic surfactant, provided that the effects of the present invention are not impaired. Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, alkyl glyceryl ethers, higher fatty acid sucrose esters, polyglycerin fatty acid esters, polyoxyethylene hydrogenated castor oil, alkyl saccharides, alkyl amine oxides, and alkyl amido amine oxides. Among the above, from the viewpoints of achieving bactericidal activity and its sustained effect, as well as suppressing a decrease in drying speed, one or more selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters, alkyl glucosides, and alkyl glyceryl ethers are preferred, and polyoxyethylene alkyl ethers are more preferred. The alkyl group in the polyoxyethylene alkyl ether, alkyl glucoside, alkyl glyceryl ether, alkyl saccharide, alkyl amine oxide, and alkyl amidoamine oxide, the alkenyl group in the polyoxyethylene alkenyl ether, and the fatty acid in the polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, higher fatty acid sucrose ester, and polyglycerin fatty acid ester preferably have 8 or more and 22 or less carbon atoms, more preferably 10 or more and 18 or less carbon atoms.

[0048] When the composition of the present invention contains component (E), the content of component (E) in the composition is preferably 0.005% by mass or more, and from the viewpoints of the bactericidal activity, its sustained effect, and suppressing a decrease in the drying rate, the content of component (E) in the composition is preferably less than 0.1% by mass, more preferably 0.05% by mass or less. Furthermore, the content of component (E) in the total amount of surfactants (excluding those corresponding to components (B) and (C)) is, from the viewpoint of improving bactericidal activity and its sustained effect, preferably 80 mass% or more, more preferably 85 mass% or more, even more preferably 90 mass% or more, still more preferably 95 mass% or more, and most preferably 100 mass%.

[0049] <Water> The composition of the present invention preferably further contains water from the viewpoint of dissolving or dispersing the components (A) to (C) and from the viewpoint of facilitating application to an object. When the composition of the present invention contains water, the content of water in the composition varies depending on the formulation, but from the viewpoint of dissolving or dispersing the components (A) to (C) and from the viewpoint of facilitating application to the target object, it is preferably 50% by mass or more, more preferably 70% by mass or more, even more preferably 80% by mass or more, still more preferably 85% by mass or more, still more preferably more than 90%, and still more preferably 95% by mass or more. The upper limit is 99.78% by mass or less, and preferably 99.5% by mass or less. The content of water in the composition may be the remainder of the components (A) to (C). From this viewpoint, the total content of the components (A) to (C) and water in the composition is preferably 60 mass% or more, more preferably 70 mass% or more, even more preferably 80 mass% or more, still more preferably 90 mass% or more, and even more preferably 95 mass% or more, and is 100 mass% or less.

[0050] <Aqueous medium> The composition of the present invention may further contain an aqueous medium other than water from the viewpoint of dissolving the components (A) to (C) and from the viewpoint of facilitating application to an object. Examples of the aqueous medium other than water include monoalcohols having 5 or less carbon atoms, such as ethanol and isopropyl alcohol. However, the composition of the present invention can exhibit bactericidal activity even if the content of ethanol is small.The content of ethanol in the composition is preferably 5.0% by mass or less, more preferably 3.0% by mass or less, even more preferably 1.0% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, even more preferably 0.07% by mass or less, even more preferably 0.05% by mass or less, and may be substantially 0% by mass.

[0051] <Other ingredients> In addition to the components described above, the composition of the present invention may contain other components as necessary, such as anionic surfactants (excluding those corresponding to component (C)), amphoteric surfactants (excluding those corresponding to component (B)), pH adjusters other than component (C) (e.g., sodium hydroxide), thickeners, ultraviolet absorbers, antioxidants, preservatives, antiperspirants, fragrances, moisturizers, texture adjusters, and anti-inflammatory agents.

[0052] From the viewpoints of bactericidal activity and its sustained effect, suppressing a decrease in drying speed, and suppressing skin irritation, it is preferable that the content of the components described below is low. The content of benzyl alcohol in the composition of the present invention is preferably less than 0.5% by mass, more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, still more preferably 0.07% by mass or less, still more preferably 0.05% by mass or less, and may be essentially 0% by mass, from the viewpoints of bactericidal activity and its sustained effect, as well as suppressing a decrease in the drying rate, the low-temperature stability of the composition, and suppressing skin irritation.

[0053] The content of plant-derived components in the composition of the present invention is, from the viewpoints of bactericidal activity and its sustained effect, suppressing a decrease in the drying rate, and the low-temperature stability of the composition, preferably less than 0.5% by mass, more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, still more preferably 0.07% by mass or less, still more preferably less than 0.05% by mass, still more preferably less than 0.01% by mass, and may be essentially 0% by mass. Examples of the plant-based ingredients include essential oils, plant extracts, citrus extracts, grapefruit seed extracts, calendula oil, and curcumin compounds (tetrahydrocurcuminoids).

[0054] The content of the cationic polymer in the composition of the present invention is, from the viewpoints of bactericidal activity and its sustained effect, as well as suppressing a decrease in the drying rate, preferably less than 0.1 mass%, more preferably 0.07 mass% or less, even more preferably less than 0.05 mass%, even more preferably less than 0.01 mass%, and may be essentially 0 mass%. In the present specification, the cationic polymer preferably means a polymer having cationic groups and being positively charged as a whole. "Substantially free of anionic groups and amphoteric groups" means that the molar amount of anionic groups and amphoteric groups relative to cationic groups is preferably 0.1% or less. In the present specification, the cationic group means a cationic group or a group that can be ionized to become a cationic group, and specifically includes a primary amino group, a secondary amino group, a tertiary amino group, and a quaternary ammonium group. Examples of the cationic polymer include cationic polysaccharides, cationic cellulose, cationic starch, cationic guar gum, cationic polyvinyl alcohol, polyethyleneimine, amino-modified silicone, polyether amino-modified silicone, polyquaternium-6, polyquaternium-7, polyquaternium-10, polyquaternium-11, polyquaternium-16, polyquaternium-22, polyquaternium-33, polyquaternium-37, polyquaternium-38, polyquaternium-39, polyquaternium-47, polyquaternium-49, polyquaternium-51, polyquaternium-52, polyquaternium-53, polyquaternium-61, polyquaternium-64, and polyquaternium-65.

[0055] The content of zinc salt in the composition of the present invention is, from the viewpoints of bactericidal activity and its sustained effect, as well as suppressing a decrease in the drying rate, preferably less than 0.1 mass%, more preferably 0.07 mass% or less, even more preferably less than 0.05 mass%, even more preferably less than 0.01 mass%, and may be essentially 0 mass%.

[0056] The content of the silver compound in the composition of the present invention is, from the viewpoints of bactericidal activity and its sustained effect, as well as suppressing a decrease in the drying rate, preferably less than 0.1 mass%, more preferably 0.07 mass% or less, even more preferably less than 0.05 mass%, still more preferably less than 0.01 mass%, and may be essentially 0 mass%. The content of cationic surfactants (excluding those corresponding to component (B)) in the composition of the present invention is, from the viewpoints of bactericidal activity and its sustained effect, as well as suppressing a decrease in the drying rate, preferably less than 10 mass%, more preferably 5 mass% or less, even more preferably less than 1 mass%, still more preferably less than 0.1 mass%, and may be essentially 0 mass%.

[0057] The total content of component (A), component (B) and monoalcohol having 5 or less carbon atoms in the composition is preferably 0.21% by mass or more, more preferably 0.25% by mass or more, even more preferably 0.30% by mass or more, even more preferably 0.50% by mass or more, even more preferably 1.0% by mass or more, and even more preferably 2.0% by mass or more, from the viewpoint of improving the drying speed, reducing stickiness after drying, and suppressing skin irritation, it is preferably 60% by mass or less, more preferably 40% by mass or less, even more preferably 30% by mass or less, even more preferably 20% by mass or less, even more preferably 10% by mass or less, even more preferably 5.0% by mass or less, even more preferably 3.5% by mass or less, and even more preferably 3.2% by mass or less.

[0058] <ph> The pH of the composition of the present invention at 25° C. is 3.5 or more, preferably 3.7 or more, more preferably 3.8 or more, from the viewpoint of improving bactericidal activity and its sustained effect and from the viewpoint of suppressing skin irritation. Also, from the viewpoint of improving bactericidal activity and its sustained effect, the pH is 7.0 or less, preferably 6.0 or less, more preferably 5.5 or less, even more preferably 5.0 or less, and even more preferably 4.5 or less. The pH of the composition at 25° C. can be specifically measured by the method described in the Examples.

[0059] <Viscosity> The viscosity of the composition of the present invention at 25°C is preferably 1.0 mPa·s or more, more preferably 2.0 mPa·s or more, and even more preferably 3.0 mPa·s or more, from the viewpoint of ease of spreading on the skin, and from the viewpoint of suppressing a decrease in the drying rate, it is preferably 1,000 mPa·s or less, more preferably 700 mPa·s or less, even more preferably 500 mPa·s or less, even more preferably 300 mPa·s or less, and even more preferably 100 mPa·s or less. The viscosity of the composition of the present invention at 25° C. is measured three times at 25° C. using a Brookfield viscometer (TVB-10M, manufactured by Toki Sangyo Co., Ltd.) and the average value is used. The measurement conditions according to the viscosity of the target are as follows: ·Viscosity: 1~10mPa·s Fixture L / Adp, rotation speed 60 rpm ·Viscosity: 10~100mPa·s Jig M1, rotation speed 60 rpm ·Viscosity over 100mPa·s and below 1,000mPa·s Jig M2, rotation speed 30 rpm ·Viscosity over 1,000mPa·s and below 10,000mPa·s Jig M3, rotation speed 12 rpm ·Viscosity over 10,000mPa·s and below 100,000mPa·s Jig M4, rotation speed 6 rpm

[0060] <Dosage form> The formulation of the composition is not particularly limited as long as it is liquid, and may be in the form of an emulsion composition, which may be either an oil-in-water emulsion composition or a water-in-oil emulsion composition.

[0061] As described above, the composition of the present invention is preferably a leave-on liquid germicidal composition for skin, and more preferably a leave-on liquid germicidal composition for hands. Preferred product forms include a germicidal agent or disinfectant for hands.

[0062] [Skin sterilization method] The present invention can also provide a method for disinfecting the skin, which comprises the step of applying the leave-on liquid disinfectant composition of the present invention to the skin. The method for applying the composition to the skin can be appropriately selected depending on the application site, etc., and for example, the composition can be applied by painting or spraying it onto the skin surface.

[0063] In the above method, it is preferable that after applying the composition to the skin, the composition is not removed by washing with water or the like, but is allowed to remain on the skin surface, in order to exert bactericidal properties and their sustained effect by using the composition as a leave-on liquid bactericidal composition and allowing the bactericidal components, component (A) and component (B), and component (C), to remain on the skin surface.

[0064] In the step of applying the composition to the skin, the amount of the composition to be applied is not particularly limited. From the viewpoint of exhibiting high bactericidal activity and its sustained effect, the composition is usually applied in an amount of preferably 0.1 mL to 5 mL per palm of both hands.

[0065] The composition may be applied to the skin after washing the skin in advance with water, soap, body soap, hand soap, etc., or may be applied to unwashed skin. Since the skin after washing is in a state in which the naturally existing protective components of the skin have been washed away and the defense power against bacteria and viruses present in the external environment is reduced, it is more preferable to apply the composition to the skin after washing.

[0066] [use] The present invention further provides the use of a polyol having a number of OH groups / C atoms of 0.45 or less to enhance or sustain the bactericidal effect on the skin of a bactericide other than a monoalcohol having 5 or less carbon atoms. The specific polyol, when used in combination with the bactericide, can enhance or sustain the bactericidal effect on the skin based on the above-mentioned mechanism of action. In the above, the disinfectant other than the monoalcohol having 5 or less carbon atoms, the polyol having the number of OH groups / the number of C atoms of 0.45 or less, and the preferred embodiments thereof are the same as the above-mentioned component (B) and the above-mentioned component (A), respectively. EXAMPLES

[0067] The present invention will be described below with reference to examples, but the present invention is not limited to the scope of the examples. In the examples, various measurements and evaluations were carried out by the following methods.

[0068] (pH) The pH of the disinfectant composition was measured at 25° C. using a pH meter (electrode: 6367-10D (manufactured by Horiba, Ltd.)).

[0069] (Preparation of bacterial solution) For the evaluation of bactericidal activity, a bacterial liquid of Serratia marcescens (NBRC12648 strain) prepared by the following method was used. Serratia marcescens (NBRC12648 strain) was inoculated into 4 mL of LB liquid medium (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., LB medium "Daigo") in a sterilized culture tube (Watson, 2332-012S), and cultured with shaking at 37 ° C. for 16 hours. After the culture was completed, the culture solution was dispensed into two sterilized microtubes (Watson, Hyper Microtube 132-620CS) at 1.6 mL each, and centrifuged at 8000 G for 3 minutes in a centrifuge (Tomy Seiko, MX-307). Next, after removing the LB liquid medium, 1.6 mL of pure water was added, mixed with a vortex mixer (Kenis, "Vortex-Genie2") for 30 seconds, centrifuged with a centrifuge at 8000 G for 3 minutes, and a washing operation to remove pure water was performed twice. Next, the Serratia bacteria were collected, and the solution in which the Serratia bacteria were suspended in pure water was measured for turbidity (OD) at a wavelength of 600 nm using a spectrophotometer (Eppendorf BioSpectrometer basic). 600 The concentration was adjusted to 10 to obtain a bacterial solution.

[0070] [a. Bactericidal activity (log reduction value) immediately after application of the composition] The subject's inner forearm was wetted with tap water at 20°C for 10 seconds, one push of "Biore u Rg" (Kao Corporation) was applied, the forearm was scrubbed for 30 seconds, and then rinsed with tap water at 20°C for 30 seconds. After waiting for 10 minutes in an environment of 25°C and 60% RH, the disinfectant composition shown in Tables 1 to 8 was applied to the skin surface (2.0 cm) of the inner forearm. 2 In Reference Examples 1 and 2, a fixed amount (2.0 μL / 2.0 cm ) was applied to the stainless steel surface and the glass surface, respectively. 2 ) and applied evenly. After leaving the mixture to stand for 5 minutes and drying, a fixed amount (2.0 μL / 2.0 cm ) of the bacterial liquid prepared by the above method was applied to the skin surface after application of the disinfectant composition. 2 ), and was evenly applied. After leaving it in this state for a specified time ("Contact time with bacteria" listed in the table), the applied bacterial liquid was collected using two culture swabs and 1.5 mL of neutralizing solution (3 g / L lecithin (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., lecithin, soybean-derived), 20 g / L Tween 80 (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., polyoxyethylene (20) sorbitan monooleate), 0.02 M disodium hydrogen phosphate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., disodium hydrogen phosphate dodecahydrate), 0.01 M sodium dihydrogen phosphate (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., sodium dihydrogen phosphate dihydrate), 9 g / L sodium chloride (manufactured by Sigma-Aldrich, sodium chloride, for biochemistry) aqueous solution). Next, the number of viable bacteria was measured using an incubation reader "HiTS" (manufactured by Synix Corporation) by the method described below, and the reduction in the number of bacteria (number of viable bacteria / initial number of viable bacteria) was confirmed. The cells were cultured in a liquid culture reader "HiTS" at 37°C, and the absorbance (turbidity) OD at a wavelength of 600 nm was measured. 600 The number of viable bacteria in the bacterial solution was measured over time, and a growth curve of the number of viable bacteria in the bacterial solution was created. At the same time, a bacterial solution with a known number of viable bacteria was serially diluted, and similarly cultured and a growth curve was created, and a calibration curve of the time to reach a certain turbidity and the number of viable bacteria was created. From the relationship between the time to reach a certain turbidity for each sample and the calibration curve, the number of viable bacteria in the collected bacterial solution was estimated, and the reduction in the number of bacteria was confirmed. The degree of reduction in the number of bacteria (log reduction value) was calculated by taking the -log value of the reduction in the number of bacteria, and is shown as "Evaluation result a" in Tables 1 to 8. A larger value indicates a higher bactericidal activity.

[0071] [b. Evaluation of the persistence of the composition: bactericidal activity after time (log reduction value)] The same procedure as in a. above was carried out, except that the standing time (5 minutes) after application of the bactericidal composition shown in Tables 1, 2, and 8 to the target object was changed to the "standing time for evaluating persistence" shown in each table. The degree of reduction in the number of bacteria (logarithmic reduction value) was calculated as the -log value of the reduction in the number of bacteria, and shown as "Evaluation result b" in Tables 1, 2, and 8. The higher this value, the higher the bactericidal activity.

[0072] [c. Bactericidal activity (log reduction value) immediately after application of pure water] Using pure water instead of the compositions shown in Tables 1 to 8, the bactericidal activity was evaluated in the same manner as in a. above (evaluation result c).

[0073] [d. Evaluation of the durability of pure water: Bactericidal activity after time (log reduction value)] Pure water was used in place of the compositions shown in Tables 1, 2, and 8, and the bactericidal activity was evaluated in the same manner as in c. above (evaluation result d).

[0074] Furthermore, the difference (ac) between evaluation results a and c, and the difference (bd) between evaluation results b and d were calculated and are shown in Tables 1 to 8 and Tables 1, 2, and 8, respectively. A larger value of (ac) indicates a higher bactericidal activity improvement effect immediately after application of the bactericidal composition (initial stage), and a larger value of (bd) indicates a higher sustained bactericidal activity effect.

[0075] (Time to dry) The time from immediately after the subject started spreading the disinfectant composition on the hand to the time when the applied composition felt completely dry was measured. The average time measured by the five subjects was taken as the evaluation value, and is shown in Tables 1 to 8 as "time to dryness (seconds)".

[0076] (Feel when applied to hands and fingers) Both hands of the subject were wetted with tap water at 20°C for 10 seconds, and one pump of "Biore u Rg" (manufactured by Kao Corporation) was applied to both hands, which were then scrubbed for 30 seconds, and then rinsed with tap water at 20°C for 30 seconds. After waiting for 2 minutes in an environment of 25°C and relative humidity of 50%RH, 1.0 mL of the disinfectant composition was applied to the palm of one hand and spread evenly over both hands, and the following items were evaluated. The evaluation was performed in an environment of an air temperature of 25°C and a relative humidity of 60%RH. The evaluation was performed by five expert panelists, and the average scores of the five panelists are shown in Table 5.

[0077] [No squeaking during the drying process] The subject spread the disinfectant composition evenly over both hands, and 90 seconds later, the absence of squeaking of the entire hand was evaluated on a 5-point scale according to the following evaluation criteria. The average score was used as the evaluation value, and is shown in Table 5 as "absence of squeaking during drying." In the evaluation criteria, the absence of squeaking during the drying process of Example 5 was evaluated as 3, which is better than the conventional product, and most of the other Examples performed even better than that, and the higher the value, the better the absence of squeaking during the drying process. Squeak from Example 5: 1 Slightly more squeaky than Example 5, but still within acceptable range: 2 Same as Example 5: 3 Slightly less squeaky than Example 5: 4 Less squeaky than Example 5: 5

[0078] (Moisturizing feeling after drying) The disinfectant composition was evenly spread over both hands, and the moist feeling of the entire hands and fingers after drying for 5 minutes was evaluated on a 5-point scale according to the following evaluation criteria. The average score was used as the evaluation value, and is shown in Table 5 as "moist feeling after drying". In the evaluation criteria, the moist feeling after drying of Example 5 was evaluated as 3, which is better than the conventional product, and most of the other Examples performed even better than that, and the higher the value, the better the moist feeling after drying. Less moist than Example 5: 1 Slightly less moist than Example 5, but still within acceptable range: 2 Same as Example 5: 3 Slightly more moist than Example 5: 4 More moist than Example 5: 5

[0079] Examples 1 to 27, Reference Examples 1 to 2, Comparative Examples 1 to 8 (Preparation and Evaluation of Leave-on Liquid Fungicide Compositions) The components shown in the table were mixed in the amounts shown in the table at room temperature to prepare leave-on liquid fungicide compositions. The amount of each component shown in Tables 1 to 8 is the amount of active ingredient (mass%) of each component. The obtained compositions were evaluated by the above-mentioned methods. The results are shown in Tables 1 to 8, and the components used are shown in Table 9.

[0080] [Table 1]

[0081] [Table 2]

[0082] [Table 3]

[0083] [Table 4]

[0084] [Table 5]

[0085] [Table 6]

[0086] [Table 7]

[0087] [Table 8]

[0088] [Table 9]

[0089] It is apparent from Tables 1 to 8 that the composition of the present invention has excellent bactericidal activity and its sustained effect, and dries quickly. A comparison of Comparative Example 1 with Reference Examples 1 and 2 in Table 1 shows that a germicidal composition that does not contain component (A) and contains only component (B) as a germicide is less likely to achieve germicidal properties when the target object is skin (Comparative Example 1) than stainless steel or glass (Reference Examples 1 and 2). In contrast, a comparison of Example 1 with Comparative Example 1 in Table 1 shows that the composition of the present invention has improved germicidal properties and its sustained effect even when applied to skin. Comparing Example 2 with Comparative Examples 2 to 4 in Table 2, Comparative Example 2 not containing component (B), Comparative Example 3 not containing component (A), and Comparative Example 4 using component (D) instead of component (A) all showed reduced bactericidal activity and its sustained effect. Comparing Examples 9 to 11 with Comparative Example 5 in Table 4, it is clear that when the mass ratio (trivalent metal ion / component (A)) exceeds 0.2, the drying speed of the composition decreases.

[0090] In Table 5, the influence of metal ion species on the performance of the leave-on liquid fungicide composition was examined. Comparing Example 5 with Examples 9 and 12, it can be seen that Examples 9 and 12, which have a higher sodium ion concentration in the composition, are better in terms of the absence of squeaking during the drying process and the moist feeling after drying. On the other hand, the compositions of Example 10 and Comparative Example 5, which contain aluminum ions, a trivalent metal ion, showed a decrease in the absence of squeaking during the drying process and the moist feeling after drying, even when sodium ions were included. [Industrial Applicability]

[0091] According to the present invention, it is possible to provide a leave-on liquid disinfectant composition which contains a disinfectant other than a monoalcohol having 5 or less carbon atoms, has excellent disinfecting properties particularly on the skin and its sustained effect, and dries quickly.< / ph>

Claims

1. Component (A): a polyol having a number of OH groups / number of carbon atoms of 0.45 or less; Component (B): a disinfectant other than component (A) and a monoalcohol having 5 or less carbon atoms, and Component (C): Carboxylic acid or its salt A leave-on liquid fungicide composition comprising: the content of the component (A) in the composition is 0.2% by mass or more and 30% by mass or less, the content of the component (B) in the composition is 0.01% by mass or more and 10% by mass or less, the content of the component (C) in the composition is 0.01% by mass or more and 15% by mass or less, the mass ratio of trivalent metal ions to component (A) in the composition (trivalent metal ions / component (A)) is 0.20 or less; A leave-on liquid disinfectant composition having a pH of 3.5 or more and 7.0 or less at 25°C.

2. 2. The leave-on liquid disinfectant composition according to claim 1, wherein the component (B) is at least one selected from the group consisting of cationic disinfectants, iodine disinfectants, phenolic disinfectants, biguanide disinfectants, terpenoid disinfectants, chlorine disinfectants, and amphoteric surfactant disinfectants.

3. 3. The leave-on liquid disinfectant composition according to claim 1, wherein the mass ratio of component (B) to component (A) in the composition (component (B) / component (A)) is 0.001 or more and 5 or less.

4. The leave-on liquid disinfectant composition according to claim 1 or 2, further comprising component (D): 0.01 mass % or more and 5.0 mass % or less of a polyol having a number of OH groups / number of carbon atoms greater than 0.

45.

5. The leave-on liquid disinfectant composition according to claim 1 or 2, further comprising 0.005% by mass or more and less than 0.1% by mass of a component (E): a nonionic surfactant.