Spirocyclic lactams as JAK2 V617F inhibitors

Abstract

The present application provides spirocyclic lactam compounds of formula I that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer. TIFF2024507935000268.tif58164

Description

[Technical Field]

[0001] The present invention provides spirocyclic lactam compounds that modulate the activity of the V617F variant of JAK2 and are useful in the treatment of diseases associated with the V617F variant of JAK2, including cancer. [Background technology]

[0002] Janus kinase (JAK) 2 plays a key role in signal transduction by several cytokine receptors. The mutant JAK2 V617F is the most common molecular event associated with myeloproliferative neoplasms. Selective targeting of the JAK2 V617F mutant may be useful for treating various disease states while omitting essential JAK2 function. The present application addresses this need and others. Summary of the Invention

[0003] The present invention relates inter alia to compounds of formula I: [ka] or a pharmaceutically acceptable salt thereof, the constituents of which are defined herein.

[0004] The present invention further provides a pharmaceutical composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

[0005] The present invention further provides a method of inhibiting the activity of the V617F variant of JAK2 kinase, comprising contacting the kinase with a compound of Formula I, or a pharmaceutically acceptable salt thereof.

[0006] The present invention further provides a method of treating a disease or disorder associated with expression or activity of the V617F variant of JAK2 kinase in a patient by administering to the patient a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof.

[0007] The present invention further provides a compound of Formula I, or a pharmaceutically acceptable salt thereof, for use in any of the methods described herein.

[0008] The invention further provides the use of a compound of formula I, or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in any of the methods described herein. DETAILED DESCRIPTION OF THE INVENTION

[0009] The present application relates to a compound of formula I: [ka] or a pharmaceutically acceptable salt thereof, wherein: W is CR W , C(R W )2, N, NR W , O, or S; Y is CR Y , C(R Y )2, N, NR Y , O, or S; At least one of the Ws is CR W Or C(R W )2 or Y is CR Y Or C(R Y )2, Each R W are independently H, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, Each R Y are independently H, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, Ring A is C 3-10 cycloalkyl or 4- to 11-membered heterocycloalkyl, and C of ring A 3-10The cycloalkyl and 4- to 11-membered heterocycloalkyl each optionally have 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6 is substituted with a substituent, R 2 But, H, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a2 , S.R. a2 , NHOR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)NR c2 (OR a2 ), C(O)OR a2 ,OC(O)R b2 , OC(O)NR c2 R d2 , N.R. c2 R d2 , N.R. c2 NR c2 R d2 , N.R. c2 C(O)R b2 , N.R. c2 C(O)OR a2 , N.R. c2 C(O)NR c2 R d2 , C(=NR e2 )R b2 , C(=NR e2 )NR c2 R d2 , N.R. c2 C(=NR e2 )NR c2 R d2 , N.R.c2 C(=NR e2 )R b2 , N.R. c2 S(O)R b2 , N.R. c2 S(O)NR c2 R d2 , N.R. c2 S(O)2R b2 , N.R. c2 S(O)(=NR e2 )R b2 , N.R. c2 S(O)NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O)2R b2 , S(O)NR c2 R d2 , OS(O)(=NR e2 )R b2 , and OS(O)2R b2 Selected from R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2A is substituted with a substituent, Each R a2 , R c2 , and R d2 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a2 , R c2 , and R d2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c2 and R d2 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R b2 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2A is substituted with a substituent, Each R e2 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 2A But, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a21 , S.R. a21 , NHOR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 NR c21 R d21 , N.R. c21 C(O)R b21 , N.R. c21 C(O)OR a21 , N.R. c21 C(O)NR c21 R d21 , C(=NR e21 )R b21 , C(=NR e21 )NR c21 R d21 , N.R. c21 C(=NR e21 )NR c21 R d21 , N.R. c21 C(=NR e21 )R b21 , N.R. c21 S(O)R b21 , N.R. c21 S(O)NR c21 R d21 , N.R. c21 S(O)2R b21 , N.R. c21S(O)(=NR e21 )R b21 , N.R. c21 S(O)NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 , S(O)2R b21 , S(O)NR c21 R d21 , OS(O)(=NR e21 )R b21 , and OS(O)2R b21 Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2B is substituted with a substituent, Each R a21 , R c21 , and R d21 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6alkyl-, and R a21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2B Is substituted with a substituent, Alternatively, any R bonded to the same N atom c21 and R d21 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 2B is substituted with a substituent, Each R b21 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b21 C 1-6 Alkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2B is substituted with a substituent, Each R e21 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a22 , S.R. a22 , NHOR a22 , C(O)R b22 , C(O)NR c22 R d22 , C(O)NR c22 (OR a22 ), C(O)OR a22 ,OC(O)R b22 , OC(O)NR c22 R d22 , N.R. c22 R d22 , N.R. c22 NR c22 R d22 , N.R. c22 C(O)R b22 , N.R. c22 C(O)OR a22 , N.R. c22 C(O)NR c22 R d22 , C(=NR e22 )R b22 , C(=NR e22 )NR c22 R d22 , N.R. c22 C(=NR e22 )NR c22 R d22 , N.R. c22 C(=NR e22 )R b22 , N.R. c22 S(O)R b22 , N.R. c22 S(O)NR c22 R d22 , N.R. c22 S(O)2R b22 , N.R. c22 S(O)(=NR e22 )R b22 , N.R. c22 S(O)NR c22 R d22 , S(O)R b22 , S(O)NR c22 R d22 , S(O)2R b22 , S(O)NR c22R d22 , OS(O)(=NR e22 )R b22 , and OS(O)2R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C is substituted with a substituent, Each R a22 , R c22 , and R d22 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a22 , R c22 , and R d22 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C Is substituted with a substituent, Alternatively, any R bonded to the same N atom c22 and R d22 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R b22 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b22 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C is substituted with a substituent, Each R e22 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 2C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a23 , S.R. a23 , NHOR a23 , C(O)R b23 , C(O)NR c23 R d23, C(O)NR c23 (OR a23 ), C(O)OR a23 ,OC(O)R b23 , OC(O)NR c23 R d23 , N.R. c23 R d23 , N.R. c23 NR c23 R d23 , N.R. c23 C(O)R b23 , N.R. c23 C(O)OR a23 , N.R. c23 C(O)NR c23 R d23 , C(=NR e23 )R b23 , C(=NR e23 )NR c23 R d23 , N.R. c23 C(=NR e23 )NR c23 R d23 , N.R. c23 C(=NR e23 )R b23 , N.R. c23 S(O)R b23 , N.R. c23 S(O)NR c23 R d23 , N.R. c23 S(O)2R b23 , N.R. c23 S(O)(=NR e23 )R b23 , N.R. c23 S(O)NR c23 R d23 , S(O)R b23 , S(O)NR c23 R d23 , S(O)2R b23 , S(O)NR c23 R d23 , OS(O)(=NR e23 )R b23 , and OS(O)2R b23 Selected from R 2C C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R a23 , R c23 , and R d23 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R a23 , R c23 , and R d23 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M Is substituted with a substituent, Alternatively, any R bonded to the same N atom c23 and R d23together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or a 4- to 7-membered heterocycloalkyl group, and the 5- to 6-membered heteroaryl or the 4- to 7-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R b23 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R b23 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R e23 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, R 3 But, H, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a3 , S.R. a3 , NHOR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)NR c3 (OR a3 ), C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R d3 , N.R. c3 NR c3 R d3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , N.R. c3 C(O)NR c3 R d3 , C(=NR e3 )R b3 , C(=NR e3 )NR c3R d3 , N.R. c3 C(=NR e3 )NR c3 R d3 , N.R. c3 C(=NR e3 )R b3 , N.R. c3 S(O)R b3 , N.R. c3 S(O)NR c3 R d3 , N.R. c3 S(O)2R b3 , N.R. c3 S(O)(=NR e3 )R b3 , N.R. c3 S(O)NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O)2R b3 , S(O)NR c3 R d3 , OS(O)(=NR e3 )R b3 , and OS(O)2R b3 Selected from R 3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3A is substituted with a substituent, Each R a3 , R c3 , and R d3 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a3 , R c3 , and R d3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R b3 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3A is substituted with a substituent, Each R e3 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R3A But, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , S.R. a31 , NHOR a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)NR c31 (OR a31 ), C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , N.R. c31 R d31 , N.R. c31 NR c31 R d31 , N.R. c31 C(O)R b31 , N.R. c31 C(O)OR a31 , N.R. c31 C(O)NR c31 R d31 , C(=NR e31 )R b31 , C(=NR e31 )NR c31 R d31 , N.R. c31 C(=NR e31 )NR c31 R d31 , N.R. c31 C(=NR e31 )R b31 , N.R. c31 S(O)R b31 , N.R. c31 S(O)NR c31R d31 , N.R. c31 S(O)2R b31 , N.R. c31 S(O)(=NR e31 )R b31 , N.R. c31 S(O)NR c31 R d31 , S(O)R b31 , S(O)NR c31 R d31 , S(O)2R b31 , S(O)NR c31 R d31 , OS(O)(=NR e31 )R b31 , and OS(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3B is substituted with a substituent, Each R a31 , R c31 , and R d31 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a31 , R c31 , and R d31 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3B Is substituted with a substituent, Alternatively, any R bonded to the same N atom c31 and R d31 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R b31 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b31 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3B is substituted with a substituent, Each R e31 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 3B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a32 , S.R. a32 , NHOR a32 , C(O)R b32 , C(O)NR c32 R d32 , C(O)NR c32 (OR a32 ), C(O)OR a32 ,OC(O)R b32 , OC(O)NR c32 R d32 , N.R. c32 R d32 , N.R. c32 NR c32 R d32 , N.R. c32 C(O)R b32 , N.R. c32 C(O)OR a32 , N.R. c32 C(O)NR c32 R d32 , C(=NR e32 )R b32 , C(=NR e32 )NR c32 R d32 , N.R. c32 C(=NR e32 )NR c32 R d32 , N.R. c32 C(=NR e32 )R b32 , N.R. c32 S(O)R b32 , N.R. c32 S(O)NR c32 R d32 , N.R. c32 S(O)2R b32 , N.R. c32 S(O)(=NR e32 )R b32 , N.R. c32 S(O)NRc32 R d32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , S(O)NR c32 R d32 , OS(O)(=NR e32 )R b32 , and OS(O)2R b32 Selected from R 3B C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3C is substituted with a substituent, Each R a32 , R c32 , and R d32 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a32 , R c32 , and R d32 C1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3C Is substituted with a substituent, Alternatively, any R bonded to the same N atom c32 and R d32 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 3C is substituted with a substituent, Each R b32 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b32 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3C is substituted with a substituent, Each R e32 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 3C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a33、SR a33 、NHOR a33 、C(O)R b33 、C(O)NR c33 R d33 、C(O)NR c33 (OR a33 )、C(O)OR a33 、OC(O)R b33 、OC(O)NR c33 R d33 、NO c33 R d33 、NO c33 NR c33 R d33 、NO c33 C(O)R b33 、NO c33 C(O)OR a33 、NO c33 C(O)NR c33 R d33 、C(=NR e33 )R b33 、C(=NR e33 )NR c33 R d33 、NO c33 C(=NR e33 )NR c33 R d33 、NO c33 C(=NR e33 )R b33 、NO c33 SOUTH b33 、NO c33 S(O)NR c33 R d33 、NO c33 S(O)2R b33 、NO c33 S(O)(=NR) e33 )R b33 、NO c33 S(O)2NR c33 R d33 ,SOUTH b33 、S(O)NR c33 R d33 、S(O)2R b33 、S(O)2NR c33 R d33 、OS(O)(=NR e33 )R b33 、&&OS(O)2R b33 R 3C のC1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R a33 , R c33 , and R d33 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R a33 , R c33 , and R d33 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R MIs substituted with a substituent, Alternatively, any R bonded to the same N atom c33 and R d33 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or a 4- to 7-membered heterocycloalkyl group, and the 5- to 6-membered heteroaryl or the 4- to 7-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R b33 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R b33 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R e33 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, R 4 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, OH, NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; R 5 But, H, Halo, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, OH, CN, C(O)OH, C(O)NHR a5 , NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; R a5 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, OH, NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; Each R 6 are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a6 , S.R. a6 , NHOR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)NR c6 (OR a6 ), C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 NR c6 R d6 , N.R. c6 C(O)R b6 , N.R. c6 C(O)OR a6 , N.R. c6 C(O)NR c6 R d6 , C(=NR e6 )R b6 , C(=NR e6 )NR c6 R d6 , N.R. c6 C(=NR e6 )NR c6 R d6 , N.R. c6 C(=NR e6 )R b6 , N.R. c6 S(O)R b6 , N.R. c6 S(O)NR c6 R d6 , N.R. c6 S(O)2R b6 , N.R. c6 S(O)(=NR e6 )R b6, N.R. c6 S(O)NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O)2R b6 , S(O)NR c6 R d6 , OS(O)(=NR e6 )R b6 , and OS(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6A is substituted with a substituent, Each R a6 , R c6 , and R d6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a6 , R c6 , and Rd6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c6 and R d6 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R b6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6A is substituted with a substituent, Each R e6 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 6A are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C1-6 アルキル-、CN、NO2、OR a61 、SR a61 、NHOR a61 、C(O)R b61 、C(O)NR c61 R d61 、C(O)NR c61 (OR a61 )、C(O)OR a61 、OC(O)R b61 、OC(O)NR c61 R d61 、NR c61 R d61 、NR c61 NR c61 R d61 、NR c61 C(O)R b61 、NR c61 C(O)OR a61 、NR c61 C(O)NR c61 R d61 、C(=NR e61 )R b61 、C(=NR e61 )NR c61 R d61 、NR c61 C(=NR e61 )NR c61 R d61 、NR c61 C(=NR e61 )R b61 、NR c61 S(O)R b61 、NR c61 S(O)NR c61 R d61 、NR c61 S(O)2R b61 、NR c61 S(O)(=NR e61 )R b61 、NR c61 S(O)2NR c61 R d61 、S(O)R b61 、S(O)NR c61 R d61 、S(O)2R b61 、S(O)2NR c61 R d61 、OS(O)(=NR e61 )R b61, and OS(O)2R b61 Selected from R 6A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6B is substituted with a substituent, Each R a61 , R c61 , and R d61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a61 , R c61 , and R d61 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6B Is substituted with a substituent, Alternatively, any R bonded to the same N atom c61 and R d61 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R b61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b61 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6B is substituted with a substituent, Each R e61 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 6B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a62 , S.R. a62 , NHOR a62 , C(O)R b62 , C(O)NR c62 R d62 , C(O)NR c62 (OR a62 ), C(O)OR a62 ,OC(O)R b62 , OC(O)NR c62 Rd62 , N.R. c62 R d62 , N.R. c62 NR c62 R d62 , N.R. c62 C(O)R b62 , N.R. c62 C(O)OR a62 , N.R. c62 C(O)NR c62 R d62 , C(=NR e62 )R b62 , C(=NR e62 )NR c62 R d62 , N.R. c62 C(=NR e62 )NR c62 R d62 , N.R. c62 C(=NR e62 )R b62 , N.R. c62 S(O)R b62 , N.R. c62 S(O)NR c62 R d62 , N.R. c62 S(O)2R b62 , N.R. c62 S(O)(=NR e62 )R b62 , N.R. c62 S(O)NR c62 R d62 , S(O)R b62 , S(O)NR c62 R d62 , S(O)2R b62 , S(O)NR c62 R d62 , OS(O)(=NR e62 )R b62 , and OS(O)2R b62 Selected from R 6B C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6C is substituted with a substituent, Each R a62 , R c62 , and R d62 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R a62 , R c62 , and R d62 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6C Is substituted with a substituent, Alternatively, any R bonded to the same N atom c62 and R d62together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or a 4- to 7-membered heterocycloalkyl group, and the 5- to 6-membered heteroaryl or the 4- to 7-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 6C is substituted with a substituent, Each R b62 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R b62 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6C is substituted with a substituent, Each R e62 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 6C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a63 , S.R. a63 , NHOR a63 , C(O)R b63 , C(O)NR c63 R d63 , C(O)NR c63 (OR a63 ), C(O)OR a63 ,OC(O)R b63 , OC(O)NR c63 R d63 , N.R. c63 R d63 , N.R. c63 NR c63 R d63 , N.R. c63 C(O)R b63 , N.R. c63 C(O)OR a63 , N.R. c63 C(O)NR c63 R d63 , C(=NR e63 )R b63 , C(=NR e63 )NR c63 R d63 , N.R.c63 C(=NR e63 )NR c63 R d63 , N.R. c63 C(=NR e63 )R b63 , N.R. c63 S(O)R b63 , N.R. c63 S(O)NR c63 R d63 , N.R. c63 S(O)2R b63 , N.R. c63 S(O)(=NR e63 )R b63 , N.R. c63 S(O)NR c63 R d63 , S(O)R b63 , S(O)NR c63 R d63 , S(O)2R b63 , S(O)NR c63 R d63 , OS(O)(=NR e63 )R b63 , and OS(O)2R b63 Selected from R 6C C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R a63 , R c63 , and R d63 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R a63 , R c63 , and R d63 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M Is substituted with a substituent, Alternatively, any R bonded to the same N atom c63 and R d63 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or a 4- to 7-membered heterocycloalkyl group, and the 5- to 6-membered heteroaryl or the 4- to 7-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R b63 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R b63 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R e63 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, Each R M are independently H, OH, halo, oxo, CN, C(O)OH, C(O)NH2, C(O)NH(C 1-4 alkyl), C(O)N(C 1-6 alkyl)2, NH2, NO2, SF5, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, or a pharmaceutically acceptable salt thereof.

[0010] In some embodiments, W is CR W , C(R W )2, N, NR W , O, or S; Y is CR Y , C(R Y )2, N, NR Y , O, or S; In the formula, at least one of W is CR W Or C(R W )2 or Y is CR Y Or C(R Y )2, Each R W are independently H, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, Each R Y are independently H, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, Ring A is C 3-10 cycloalkyl or 4- to 10-membered heterocycloalkyl, and C of ring A 3-10 The cycloalkyl and 4- to 10-membered heterocycloalkyl each optionally have 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6 is substituted with a substituent, R 2 But, H, Halo, C1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a2 , S.R. a2 , NHOR a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)NR c2 (OR a2 ), C(O)OR a2 ,OC(O)R b2 , OC(O)NR c2 R d2 , N.R. c2 R d2 , N.R. c2 NR c2 R d2 , N.R. c2 C(O)R b2 , N.R. c2 C(O)OR a2 , N.R. c2 C(O)NR c2 R d2 , C(=NR e2 )R b2 , C(=NR e2 )NR c2 R d2 , N.R. c2 C(=NR e2 )NR c2 R d2 , N.R. c2 C(=NR e2 )R b2 , N.R. c2 S(O)R b2 , N.R. c2 S(O)NR c2 R d2 , N.R.c2 S(O)2R b2 , N.R. c2 S(O)(=NR e2 )R b2 , N.R. c2 S(O)NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O)2R b2 , S(O)NR c2 R d2 , OS(O)(=NR e2 )R b2 , and OS(O)2R b2 Selected from R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2A is substituted with a substituent, Each R a2 , R c2 , and R d2 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a2 , R c2 , and R d2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c2 and R d2 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R b2 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6alkyl-, and R b2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2A is substituted with a substituent, Each R e2 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 2A But, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a21 , S.R. a21 , NHOR a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 NR c21 R d21 , N.R. c21 C(O)R b21 , N.R. c21 C(O)OR a21 , N.R. c21 C(O)NR c21 R d21 , C(=NR e21 )R b21 , C(=NR e21 )NR c21 R d21 , N.R. c21 C(=NR e21 )NR c21 R d21 , N.R. c21 C(=NR e21 )R b21 , N.R. c21 S(O)R b21 , N.R. c21 S(O)NR c21 R d21 , N.R. c21 S(O)2R b21 , N.R. c21 S(O)(=NR e21 )R b21 , N.R. c21 S(O)NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21, S(O)2R b21 , S(O)NR c21 R d21 , OS(O)(=NR e21 )R b21 , and OS(O)2R b21 Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2B is substituted with a substituent, Each R a21 , R c21 , and R d21 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c21 and R d21 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 2B is substituted with a substituent, Each R b21 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b21 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2B is substituted with a substituent, Each R e21 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a22 , S.R. a22 , NHOR a22 , C(O)R b22, C(O)NR c22 R d22 , C(O)NR c22 (OR a22 ), C(O)OR a22 ,OC(O)R b22 , OC(O)NR c22 R d22 , N.R. c22 R d22 , N.R. c22 NR c22 R d22 , N.R. c22 C(O)R b22 , N.R. c22 C(O)OR a22 , N.R. c22 C(O)NR c22 R d22 , C(=NR e22 )R b22 , C(=NR e22 )NR c22 R d22 , N.R. c22 C(=NR e22 )NR c22 R d22 , N.R. c22 C(=NR e22 )R b22 , N.R. c22 S(O)R b22 , N.R. c22 S(O)NR c22 R d22 , N.R. c22 S(O)2R b22 , N.R. c22 S(O)(=NR e22 )R b22 , N.R. c22 S(O)NR c22 R d22 , S(O)R b22 , S(O)NR c22 R d22 , S(O)2R b22 , S(O)NR c22 R d22 , OS(O)(=NR e22 )R b22 , and OS(O)2R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C is substituted with a substituent, Each R a22 , R c22 , and R d22 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a22 , R c22 , and R d22 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C Is substituted with a substituent, Alternatively, any R bonded to the same N atom c22 and R d22 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R b22 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b22 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 2C is substituted with a substituent, Each R e22 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 2C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a23 , S.R. a23 , NHOR a23 , C(O)R b23 , C(O)NR c23 R d23 , C(O)NR c23 (OR a23 ), C(O)OR a23 ,OC(O)R b23 , OC(O)NR c23 R d23 , N.R. c23 R d23 , N.R. c23 NR c23 R d23 , N.R.c23 C(O)R b23 , N.R. c23 C(O)OR a23 , N.R. c23 C(O)NR c23 R d23 , C(=NR e23 )R b23 , C(=NR e23 )NR c23 R d23 , N.R. c23 C(=NR e23 )NR c23 R d23 , N.R. c23 C(=NR e23 )R b23 , N.R. c23 S(O)R b23 , N.R. c23 S(O)NR c23 R d23 , N.R. c23 S(O)2R b23 , N.R. c23 S(O)(=NR e23 )R b23 , N.R. c23 S(O)NR c23 R d23 , S(O)R b23 , S(O)NR c23 R d23 , S(O)2R b23 , S(O)NR c23 R d23 , OS(O)(=NR e23 )R b23 , and OS(O)2R b23 Selected from R 2C C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R a23 , R c23 , and R d23 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R a23 , R c23 , and R d23 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M Is substituted with a substituent, Alternatively, any R bonded to the same N atom c23 and R d23 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or a 4- to 7-membered heterocycloalkyl group, and the 5- to 6-membered heteroaryl or the 4- to 7-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R b23are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R b23 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R e23 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, R 3But, H, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a3 , S.R. a3 , NHOR a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)NR c3 (OR a3 ), C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R d3 , N.R. c3 NR c3 R d3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , N.R. c3 C(O)NR c3 R d3 , C(=NR e3 )R b3 , C(=NR e3 )NR c3 R d3 , N.R. c3 C(=NR e3 )NR c3 R d3 , N.R. c3 C(=NR e3 )R b3 , N.R. c3 S(O)R b3 , N.R. c3 S(O)NR c3 Rd3 , N.R. c3 S(O)2R b3 , N.R. c3 S(O)(=NR e3 )R b3 , N.R. c3 S(O)NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O)2R b3 , S(O)NR c3 R d3 , OS(O)(=NR e3 )R b3 , and OS(O)2R b3 Selected from R 3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3A is substituted with a substituent, Each R a3 , R c3 , and R d3 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a3 , R c3 , and R d3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c3 and R d3 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R b3 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3A is substituted with a substituent, Each R e3 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 3A But, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , S.R. a31 , NHOR a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)NR c31 (OR a31 ), C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , N.R. c31 R d31 , N.R. c31 NR c31 R d31 , N.R. c31 C(O)R b31 , N.R. c31 C(O)OR a31 , N.R. c31 C(O)NR c31 R d31 , C(=NR e31 )R b31 , C(=NR e31 )NR c31 R d31 , N.R. c31 C(=NR e31 )NR c31 R d31 , N.R. c31 C(=NR e31 )R b31 , N.R. c31 S(O)R b31 , N.R. c31 S(O)NR c31 R d31 , N.R. c31 S(O)2R b31 , N.R. c31 S(O)(=NR e31 )R b31 , N.R. c31 S(O)NR c31 R d31 , S(O)R b31, S(O)NR c31 R d31 , S(O)2R b31 , S(O)NR c31 R d31 , OS(O)(=NR e31 )R b31 , and OS(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3B is substituted with a substituent, Each R a31 , R c31 , and R d31 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a31 , R c31 , and R d31 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3B Is substituted with a substituent, Alternatively, any R bonded to the same N atom c31 and R d31 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R b31 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b31 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3B is substituted with a substituent, Each R e31 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 3B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a32 , S.R. a32 , NHORa32 , C(O)R b32 , C(O)NR c32 R d32 , C(O)NR c32 (OR a32 ), C(O)OR a32 ,OC(O)R b32 , OC(O)NR c32 R d32 , N.R. c32 R d32 , N.R. c32 NR c32 R d32 , N.R. c32 C(O)R b32 , N.R. c32 C(O)OR a32 , N.R. c32 C(O)NR c32 R d32 , C(=NR e32 )R b32 , C(=NR e32 )NR c32 R d32 , N.R. c32 C(=NR e32 )NR c32 R d32 , N.R. c32 C(=NR e32 )R b32 , N.R. c32 S(O)R b32 , N.R. c32 S(O)NR c32 R d32 , N.R. c32 S(O)2R b32 , N.R. c32 S(O)(=NR e32 )R b32 , N.R. c32 S(O)NR c32 R d32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , S(O)NR c32 R d32 , OS(O)(=NR e32 )R b32 , and OS(O)2R b32 Selected from R 3B C 1-6 Alkyl, C2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3C is substituted with a substituent, Each R a32 , R c32 , and R d32 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a32 , R c32 , and R d32 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3C Is substituted with a substituent, Alternatively, any R bonded to the same N atom c32 and R d32 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 3C is substituted with a substituent, Each R b32 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b32 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 3C is substituted with a substituent, Each R e32 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl, C 3-10 Cycloalkyl-C 1-6 Alkynyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 3C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a33 , S.R. a33 , NHOR a33 , C(O)R b33 , C(O)NR c33 R d33 , C(O)NR c33 (OR a33 ), C(O)OR a33 ,OC(O)R b33 , OC(O)NR c33 R d33, N.R. c33 R d33 , N.R. c33 NR c33 R d33 , N.R. c33 C(O)R b33 , N.R. c33 C(O)OR a33 , N.R. c33 C(O)NR c33 R d33 , C(=NR e33 )R b33 , C(=NR e33 )NR c33 R d33 , N.R. c33 C(=NR e33 )NR c33 R d33 , N.R. c33 C(=NR e33 )R b33 , N.R. c33 S(O)R b33 , N.R. c33 S(O)NR c33 R d33 , N.R. c33 S(O)2R b33 , N.R. c33 S(O)(=NR e33 )R b33 , N.R. c33 S(O)NR c33 R d33 , S(O)R b33 , S(O)NR c33 R d33 , S(O)2R b33 , S(O)NR c33 R d33 , OS(O)(=NR e33 )R b33 , and OS(O)2R b33 Selected from R 3C C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R a33 , R c33 , and R d33 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R a33 , R c33 , and R d33 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M Is substituted with a substituent, Alternatively, any R bonded to the same N atom c33 and R d33 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or a 4- to 7-membered heterocycloalkyl group, and the 5- to 6-membered heteroaryl or the 4- to 7-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected RM is substituted with a substituent, Each R b33 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R b33 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R e33 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, R 4 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, OH, NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; R 5 But, H, Halo, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, OH, CN, C(O)OH, C(O)NHR a5 , NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; R a5 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, OH, NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; Each R 6 are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a6 , S.R. a6 , NHOR a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)NR c6 (OR a6 ), C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 NR c6 R d6 , N.R. c6 C(O)R b6 , N.R. c6 C(O)OR a6 , N.R. c6 C(O)NR c6 R d6 , C(=NR e6 )R b6 , C(=NR e6 )NR c6 R d6 , N.R. c6 C(=NR e6 )NR c6 R d6 , N.R. c6 C(=NR e6 )R b6 , N.R. c6 S(O)R b6 , N.R. c6 S(O)NR c6 R d6 , N.R. c6 S(O)2R b6 , N.R. c6 S(O)(=NR e6 )R b6 , N.R. c6 S(O)NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O)2R b6 , S(O)NR c6 R d6, OS(O)(=NR e6 )R b6 , and OS(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6A is substituted with a substituent, Each R a6 , R c6 , and R d6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a6 , R c6 , and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c6 and R d6 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R b6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6A is substituted with a substituent, Each R e6 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 6A are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a61 , S.R. a61 , NHOR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)NR c61 (ORa61 ), C(O)OR a61 ,OC(O)R b61 , OC(O)NR c61 R d61 , N.R. c61 R d61 , N.R. c61 NR c61 R d61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , C(=NR e61 )R b61 , C(=NR e61 )NR c61 R d61 , N.R. c61 C(=NR e61 )NR c61 R d61 , N.R. c61 C(=NR e61 )R b61 , N.R. c61 S(O)R b61 , N.R. c61 S(O)NR c61 R d61 , N.R. c61 S(O)2R b61 , N.R. c61 S(O)(=NR e61 )R b61 , N.R. c61 S(O)NR c61 R d61 , S(O)R b61 , S(O)NR c61 R d61 , S(O)2R b61 , S(O)NR c61 R d61 , OS(O)(=NR e61 )R b61 , and OS(O)2R b61 Selected from R 6A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6B is substituted with a substituent, Each R a61 , R c61 , and R d61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a61 , R c61 , and R d61 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6B Is substituted with a substituent, Alternatively, any R bonded to the same N atom c61 and R d61 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R b61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b61 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6B is substituted with a substituent, Each R e61 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, Each R 6B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a62 , S.R. a62 , NHOR a62 , C(O)R b62 , C(O)NR c62 R d62 , C(O)NR c62 (OR a62 ), C(O)OR a62 ,OC(O)R b62 , OC(O)NR c62 R d62 , N.R. c62 R d62 , N.R. c62 NR c62 R d62 , N.R.c62 C(O)R b62 , N.R. c62 C(O)OR a62 , N.R. c62 C(O)NR c62 R d62 , C(=NR e62 )R b62 , C(=NR e62 )NR c62 R d62 , N.R. c62 C(=NR e62 )NR c62 R d62 , N.R. c62 C(=NR e62 )R b62 , N.R. c62 S(O)R b62 , N.R. c62 S(O)NR c62 R d62 , N.R. c62 S(O)2R b62 , N.R. c62 S(O)(=NR e62 )R b62 , N.R. c62 S(O)NR c62 R d62 , S(O)R b62 , S(O)NR c62 R d62 , S(O)2R b62 , S(O)NR c62 R d62 , OS(O)(=NR e62 )R b62 , and OS(O)2R b62 Selected from R 6B C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6C is substituted with a substituent, Each R a62 , R c62 , and R d62 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R a62 , R c62 , and R d62 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6C Is substituted with a substituent, Alternatively, any R bonded to the same N atom c62 and R d62 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or a 4- to 7-membered heterocycloalkyl group, and the 5- to 6-membered heteroaryl or the 4- to 7-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 6C is substituted with a substituent, Each R b62are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R b62 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6C is substituted with a substituent, Each R e62 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, Each R6C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a63 , S.R. a63 , NHOR a63 , C(O)R b63 , C(O)NR c63 R d63 , C(O)NR c63 (OR a63 ), C(O)OR a63 ,OC(O)R b63 , OC(O)NR c63 R d63 , N.R. c63 R d63 , N.R. c63 NR c63 R d63 , N.R. c63 C(O)R b63 , N.R. c63 C(O)OR a63 , N.R. c63 C(O)NR c63 R d63 , C(=NR e63 )R b63 , C(=NR e63 )NR c63 R d63 , N.R. c63 C(=NR e63 )NR c63 R d63 , N.R. c63 C(=NR e63 )R b63 , N.R. c63 S(O)R b63 , N.R. c63 S(O)NR c63 R d63 , N.R.c63 S(O)2R b63 , N.R. c63 S(O)(=NR e63 )R b63 , N.R. c63 S(O)NR c63 R d63 , S(O)R b63 , S(O)NR c63 R d63 , S(O)2R b63 , S(O)NR c63 R d63 , OS(O)(=NR e63 )R b63 , and OS(O)2R b63 Selected from R 6C C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R a63 , R c63 , and R d63 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R a63 , Rc63 , and R d63 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M Is substituted with a substituent, Alternatively, any R bonded to the same N atom c63 and R d63 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or a 4- to 7-membered heterocycloalkyl group, and the 5- to 6-membered heteroaryl or the 4- to 7-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R b63 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R b63 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R M is substituted with a substituent, Each R e63 are independently H, OH, CN, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, Each R M are independently H, OH, halo, oxo, CN, C(O)OH, C(O)NH2, C(O)NH(C 1-4 alkyl), C(O)N(C 1-6 alkyl)2, NH2, NO2, SF5, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-.

[0011] In some embodiments, W is CR W , C(R W )2, N, NR W , O, or S; Y is CR Y , C(R Y )2, N, NR Y , O, or S; In the formula, at least one of W is CR W Or C(R W )2 or Y is CR Y Or C(R Y )2, Each R W are independently H, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, Each R Y are independently H, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, Ring A is C 3-10 cycloalkyl or 4- to 10-membered heterocycloalkyl, and C of ring A 3-10 The cycloalkyl and 4- to 10-membered heterocycloalkyl each optionally have 1, 2, 3, or 4 independently selected R 6 is substituted with a substituent, R 2 But, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a2 , S.R. a2 , C(O)R b2 , C(O)NR c2 R d2 , C(O)NR c2 (OR a2 ), C(O)OR a2 ,OC(O)R b2 , OC(O)NR c2 R d2 , N.R. c2 R d2 , N.R. c2 C(O)R b2 , N.R. c2 C(O)OR a2 , N.R. c2 C(O)NR c2 R d2 , N.R. c2 S(O)R b2 , N.R. c2 S(O)NR c2 R d2 , N.R. c2 S(O)2R b2 , N.R. c2 S(O)NR c2 R d2 , S(O)R b2 , S(O)NR c2 R d2 , S(O)2R b2 , S(O)NR c2 R d2 , and OS(O)2R b2 Selected from R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R a2 , R c2 , and R d2 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a2 , R c2 , and R d2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c2 and R d2together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R b2 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b2 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, R 2A But, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a21 , S.R. a21 , C(O)R b21 , C(O)NR c21 R d21 , C(O)NR c21 (OR a21 ), C(O)OR a21 ,OC(O)R b21 , OC(O)NR c21 R d21 , N.R. c21 R d21 , N.R. c21 C(O)R b21 , N.R. c21 C(O)OR a21 , N.R. c21 C(O)NR c21 R d21 , N.R. c21 S(O)R b21 , N.R. c21 S(O)NR c21 R d21 , N.R. c21 S(O)2R b21 , N.R. c21 S(O)NR c21 R d21 , S(O)R b21 , S(O)NR c21 R d21 , S(O)2R b21 , S(O)NR c21 R d21 , and OS(O)2R b21 Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2B is substituted with a substituent, Each R a21 , R c21 , and R d21 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a21 , R c21 , and R d21 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2B Is substituted with a substituent, Alternatively, any R bonded to the same N atom c21 and R d21 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 2B is substituted with a substituent, Each R b21 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b21 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2B is substituted with a substituent, R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a22 , S.R. a22 , C(O)R b22 , C(O)NR c22 R d22 , C(O)NR c22 (OR a22 ), C(O)OR a22 ,OC(O)R b22 , OC(O)NR c22 R d22 , N.R. c22 R d22 , N.R. c22 C(O)R b22 , N.R. c22 C(O)OR a22 , N.R. c22 C(O)NR c22 R d22 , N.R. c22 S(O)R b22 , N.R. c22 S(O)NR c22 R d22 , N.R. c22 S(O)2R b22 , N.R. c22 S(O)NR c22 R d22 , S(O)R b22 , S(O)NR c22 R d22 , S(O)2R b22 , S(O)NR c22 R d22 , and OS(O)2R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R a22 , R c22 , and R d22 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a22 , R c22 , and R d22 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2C Is substituted with a substituent, Alternatively, any R bonded to the same N atom c22 and R d22 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R b22 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b22 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R 2Care independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a23 , S.R. a23 , C(O)R b23 , C(O)NR c23 R d23 , C(O)NR c23 (OR a23 ), C(O)OR a23 ,OC(O)R b23 , OC(O)NR c23 R d23 , N.R. c23 R d23 , N.R. c23 C(O)R b23 , N.R. c23 C(O)OR a23 , N.R. c23 C(O)NR c23 R d23 , N.R. c23 S(O)R b23 , N.R. c23 S(O)NR c23 R d23 , N.R. c23 S(O)2R b23 , N.R. c23 S(O)NR c23 R d23 , S(O)R b23 , S(O)NR c23 R d23 , S(O)2R b23 , S(O)NR c23 R d23 , and OS(O)2R b23 is selected from Each R a23 , R c23 , and R d23are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl- or Alternatively, any R bonded to the same N atom c23 and R d23 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group; Each R b23 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, R 3 But, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a3 , S.R. a3 , C(O)R b3 , C(O)NR c3 R d3 , C(O)NR c3 (OR a3 ), C(O)OR a3 ,OC(O)R b3 , OC(O)NR c3 R d3 , N.R. c3 R d3 , N.R. c3 C(O)R b3 , N.R. c3 C(O)OR a3 , N.R. c3 C(O)NR c3 R d3 , N.R. c3 S(O)R b3 , N.R. c3 S(O)NR c3 R d3 , N.R. c3 S(O)2R b3 , N.R. c3 S(O)NR c3 R d3 , S(O)R b3 , S(O)NR c3 R d3 , S(O)2R b3 , S(O)NR c3 R d3 , and OS(O)2R b3 Selected from R 3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R a3 , R c3 , and R d3 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a3 , R c3 , and R d3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c3 and R d3together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R b3 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b3 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, R 3A But, halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a31 , S.R. a31 , C(O)R b31 , C(O)NR c31 R d31 , C(O)NR c31 (OR a31 ), C(O)OR a31 ,OC(O)R b31 , OC(O)NR c31 R d31 , N.R. c31 R d31 , N.R. c31 C(O)R b31 , N.R. c31 C(O)OR a31 , N.R. c31 C(O)NR c31 R d31 , N.R. c31 S(O)R b31 , N.R. c31 S(O)NR c31 R d31 , N.R. c31 S(O)2R b31 , N.R. c31 S(O)NR c31 R d31 , S(O)R b31 , S(O)NR c31 R d31 , S(O)2R b31 , S(O)NR c31 R d31 , and OS(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R a31 , R c31 , and R d31 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a31 , R c31 , and R d31 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B Is substituted with a substituent, Alternatively, any R bonded to the same N atom c31 and R d31 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R b31 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b31 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R 3B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a32 , S.R. a32 , C(O)R b32 , C(O)NR c32 R d32 , C(O)NR c32 (OR a32 ), C(O)OR a32 ,OC(O)R b32 , OC(O)NR c32 R d32 , N.R. c32 R d32 , N.R. c32 C(O)R b32 , N.R. c32 C(O)OR a32 , N.R. c32 C(O)NR c32 R d32 , N.R. c32 S(O)R b32 , N.R. c32 S(O)NR c32 R d32 , N.R. c32 S(O)2R b32 , N.R. c32 S(O)NR c32 R d32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , S(O)NR c32 R d32 , and OS(O)2R b32 Selected from R 3B C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3C is substituted with a substituent, Each R a32 , R c32 , and R d32 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a32 , R c32 , and R d32 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3C Is substituted with a substituent, Alternatively, any R bonded to the same N atom c32 and R d32 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 3C is substituted with a substituent, Each R b32 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b32 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3C is substituted with a substituent, Each R 3Care independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a33 , S.R. a33 , C(O)R b33 , C(O)NR c33 R d33 , C(O)NR c33 (OR a33 ), C(O)OR a33 ,OC(O)R b33 , OC(O)NR c33 R d33 , N.R. c33 R d33 , N.R. c33 C(O)R b33 , N.R. c33 C(O)OR a33 , N.R. c33 C(O)NR c33 R d33 , N.R. c33 S(O)R b33 , N.R. c33 S(O)NR c33 R d33 , N.R. c33 S(O)2R b33 , N.R. c33 S(O)NR c33 R d33 , S(O)R b33 , S(O)NR c33 R d33 , S(O)2R b33 , S(O)NR c33 R d33 , and OS(O)2R b33 is selected from Each R a33 , R c33 , and R d33are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl- or Alternatively, any R bonded to the same N atom c33 and R d33 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group; Each R b33 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, R 4 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, OH, NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; R 5 But, H, Halo, C 1-6 Alkyl, C 1-6 Alkoxy, C1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, OH, CN, C(O)OH, C(O)NHR a5 , NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; R a5 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, OH, NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; R 6 are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a6 , S.R. a6 , C(O)R b6 , C(O)NR c6 R d6 , C(O)NR c6 (OR a6 ), C(O)OR a6 ,OC(O)R b6 , OC(O)NR c6 R d6 , N.R. c6 R d6 , N.R. c6 C(O)R b6 , N.R.c6 C(O)OR a6 , N.R. c6 C(O)NR c6 R d6 , N.R. c6 S(O)R b6 , N.R. c6 S(O)NR c6 R d6 , N.R. c6 S(O)2R b6 , N.R. c6 S(O)NR c6 R d6 , S(O)R b6 , S(O)NR c6 R d6 , S(O)2R b6 , S(O)NR c6 R d6 , and OS(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R a6 , R c6 , and R d6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a6 , R c6 , and R d6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A Is substituted with a substituent, Alternatively, any R bonded to the same N atom c6 and R d6 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R b6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R 6A are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a61 , S.R. a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)NR c61 (OR a61 ), C(O)OR a61 ,OC(O)R b61 , OC(O)NR c61 R d61 , N.R. c61 R d61 , N.R.c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , N.R. c61 S(O)R b61 , N.R. c61 S(O)NR c61 R d61 , N.R. c61 S(O)2R b61 , N.R. c61 S(O)NR c61 R d61 , S(O)R b61 , S(O)NR c61 R d61 , S(O)2R b61 , S(O)NR c61 R d61 , and OS(O)2R b61 Selected from R 6A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R a61 , R c61 , and R d61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R a61 , R c61 , and R d61 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6B Is substituted with a substituent, Alternatively, any R bonded to the same N atom c61 and R d61 together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or a 4- to 10-membered heterocycloalkyl group, and the 5- to 10-membered heteroaryl or the 4- to 10-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R b61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R b61 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R 6B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a62 , S.R. a62 , C(O)R b62 , C(O)NR c62 R d62 , C(O)NR c62 (OR a62 ), C(O)OR a62 ,OC(O)R b62 , OC(O)NR c62 R d62 , N.R. c62 R d62, N.R. c62 C(O)R b62 , N.R. c62 C(O)OR a62 , N.R. c62 C(O)NR c62 R d62 , N.R. c62 S(O)R b62 , N.R. c62 S(O)NR c62 R d62 , N.R. c62 S(O)2R b62 , N.R. c62 S(O)NR c62 R d62 , S(O)R b62 , S(O)NR c62 R d62 , S(O)2R b62 , S(O)NR c62 R d62 , and OS(O)2R b62 Selected from R 6B C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6C is substituted with a substituent, Each R a62 , R c62 , and R d62 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R a62 , R c62 , and R d62 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6C Is substituted with a substituent, Alternatively, any R bonded to the same N atom c62 and R d62 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or a 4- to 7-membered heterocycloalkyl group, and the 5- to 6-membered heteroaryl or the 4- to 7-membered heterocycloalkyl group is optionally selected from 1, 2, 3, or 4 independently selected R 6C is substituted with a substituent, Each R b62 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, and R b62 C 1-6Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6C is substituted with a substituent, Each R 6C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, NO2, OR a63 , S.R. a63 , C(O)R b63 , C(O)NR c63 R d63 , C(O)NR c63 (OR a63 ), C(O)OR a63 ,OC(O)R b63 , OC(O)NR c63 R d63 , N.R. c63 R d63 , N.R. c63 C(O)R b63 , N.R. c63 C(O)OR a63 , N.R. c63 C(O)NR c63 R d63 , N.R. c63 S(O)R b63 , N.R.c63 S(O)NR c63 R d63 , N.R. c63 S(O)2R b63 , N.R. c63 S(O)NR c63 R d63 , S(O)R b63 , S(O)NR c63 R d63 , S(O)2R b63 , S(O)NR c63 R d63 , and OS(O)2R b63 is selected from Each R a63 , R c63 , and R d63 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl- or Alternatively, any R bonded to the same N atom c63 and R d63 together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group; Each R b63 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-.

[0012] In some embodiments, W is C(R W )2, NR W , O, or S.

[0013] In some embodiments, W is C(R W )2 or NR W is.

[0014] In some embodiments, W is C(R W )2.

[0015] In some embodiments, each R W are independently H or C 1-6 It is alkyl.

[0016] In some embodiments, each R W are independently H or C 1-6 alkyl, and R W wherein one or more hydrogen atoms are optionally replaced by deuterium atoms.

[0017] In some embodiments, each R W are independently H or C 1-3 It is alkyl.

[0018] In some embodiments, W is CH2.

[0019] In some embodiments, Y is C(R Y )2, NR Y , O, or S.

[0020] In some embodiments, Y is C(R Y )2 or NR Y is.

[0021] In some embodiments, Y is C(R Y )2.

[0022] In some embodiments, each R Y are independently H or C 1-6 It is alkyl.

[0023] In some embodiments, each R Y are independently H or C 1-6 alkyl, and R Y wherein one or more hydrogen atoms are optionally replaced by deuterium atoms.

[0024] In some embodiments, each R Y are independently H or C 1-3 It is alkyl.

[0025] In some embodiments, Y is CH2.

[0026] In some embodiments, W is C(R W )2, NR W , O, or S; Y is C(R Y )2, NR Y , O, or S.

[0027] In some embodiments, W is C(R W )2 or NR W and Y is C(R Y )2 or NR Y is.

[0028] In some embodiments, W is C(R W )2, Y is C(R Y )2.

[0029] In some embodiments, W is C(R W )2, Y is C(R Y )2, Each R W are independently H or C 1-6 is alkyl, Each R Y are independently H or C 1-6 It is alkyl.

[0030] In some embodiments, W is C(R W )2, Y is C(R Y )2, Each R W are independently H or C 1-3 is alkyl, Each R Y are independently H or C 1-3 It is alkyl.

[0031] In some embodiments, W and Y are each CH2.

[0032] In some embodiments, ring A optionally contains 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6 substituted by a substituent, C 3-10 It is cycloalkyl.

[0033] In some embodiments, ring A optionally contains 1, 2, 3, or 4 independently selected R 6 substituted by a substituent, C 3-10 It is cycloalkyl.

[0034] In some embodiments, ring A optionally contains 1, 2, 3, or 4 independently selected R 6 substituted by a substituent, C 8-10 It is cycloalkyl.

[0035] In some embodiments, ring A optionally contains 1, 2, 3, or 4 independently selected R 6 substituted by a substituent, C 3-7 It is cycloalkyl.

[0036] In some embodiments, ring A optionally contains 1, 2, 3, or 4 independently selected R 6 Monocyclic C substituted by a substituent 3-7 It is cycloalkyl.

[0037] In some embodiments, ring A optionally contains one or two independently selected R 6 substituted by a substituent, C 3-7 It is cycloalkyl.

[0038] In some embodiments, ring A optionally contains 1, 2, 3, or 4 independently selected R 6 Bicyclic C substituted by substituents 8-10 It is cycloalkyl.

[0039] In some embodiments, ring A optionally contains one or two independently selected R 6 Bicyclic C substituted by substituents 8-10 It is cycloalkyl.

[0040] In some embodiments, ring A optionally contains 1, 2, 3, or 4 independently selected R 6 Spirocyclic C substituted by substituents 7-10 It is cycloalkyl.

[0041] In some embodiments, ring A optionally contains one or two independently selected R 6 Spirocyclic C substituted by substituents 7-10 It is cycloalkyl.

[0042] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, and dihydroindenyl, and the cyclobutyl, cyclopentyl, cyclohexyl, and dihydroindenyl of ring A are each optionally joined to 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0043] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, and 2,3-dihydro-1H-indenyl, and the cyclobutyl, cyclopentyl, cyclohexyl, and 2,3-dihydro-1H-indenyl of ring A are each optionally joined to 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0044] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, and cyclohexyl, and the cyclobutyl, cyclopentyl, and cyclohexyl of ring A are each optionally joined to 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0045] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, and dihydroindenyl, and each of the cyclobutyl, cyclopentyl, cyclohexyl, and dihydroindenyl of ring A is optionally coupled to one or two independently selected R 6 It is substituted by a substituent.

[0046] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, and 2,3-dihydro-1H-indenyl, and each of the cyclobutyl, cyclopentyl, cyclohexyl, and 2,3-dihydro-1H-indenyl of ring A is optionally coupled to one or two independently selected R 6 It is substituted by a substituent.

[0047] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, and cyclohexyl, and the cyclobutyl, cyclopentyl, and cyclohexyl of ring A are each optionally joined to one or two independently selected R 6 It is substituted by a substituent.

[0048] In some embodiments, ring A is an unsubstituted C 3-10 It is cycloalkyl.

[0049] In some embodiments, ring A is an unsubstituted C 8-10 It is cycloalkyl.

[0050] In some embodiments, ring A is an unsubstituted bicyclic C 8-10 It is cycloalkyl.

[0051] In some embodiments, ring A is an unsubstituted C 3-7 It is cycloalkyl.

[0052] In some embodiments, ring A is an unsubstituted monocyclic C 3-7 It is cycloalkyl.

[0053] In some embodiments, ring A is chosen from cyclobutyl, cyclopentyl, cyclohexyl, and dihydroindenyl.

[0054] In some embodiments, ring A is chosen from cyclobutyl, cyclopentyl, cyclohexyl, and 2,3-dihydro-1H-indenyl.

[0055] In some embodiments, ring A is chosen from cyclobutyl, cyclopentyl, and cyclohexyl.

[0056] In some embodiments, ring A optionally contains 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6 It is a 4- to 11-membered heterocycloalkyl substituted by a substituent.

[0057] In some embodiments, ring A optionally contains 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R 6 It is a 4- to 10-membered heterocycloalkyl substituted by a substituent.

[0058] In some embodiments, ring A optionally contains 1, 2, 3, or 4 independently selected R 6 It is a 4- to 11-membered heterocycloalkyl substituted by a substituent.

[0059] In some embodiments, ring A optionally contains 1, 2, 3, or 4 independently selected R 6 It is a 4- to 10-membered heterocycloalkyl substituted by a substituent.

[0060] In some embodiments, ring A is a monocyclic 4-6 membered heterocycloalkyl or a bicyclic 8-10 membered heterocycloalkyl, and the monocyclic 4-6 membered heterocycloalkyl and bicyclic 8-10 membered heterocycloalkyl of ring A each optionally contains 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0061] In some embodiments, ring A is a monocyclic 4-6 membered heterocycloalkyl, a bicyclic 8-10 membered heterocycloalkyl, or a spirocyclic 7-11 membered heterocycloalkyl, and the monocyclic 4-6 membered heterocycloalkyl, bicyclic 8-10 membered heterocycloalkyl, and spirocyclic 7-11 membered heterocycloalkyl of ring A each optionally contains 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0062] In some embodiments, ring A is a monocyclic 4-6 membered heterocycloalkyl, a bicyclic 8-10 membered heterocycloalkyl, or a spirocyclic 7-10 membered heterocycloalkyl, and the monocyclic 4-6 membered heterocycloalkyl, bicyclic 8-10 membered heterocycloalkyl, and spirocyclic 7-10 membered heterocycloalkyl of ring A each optionally contains 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0063] In some embodiments, ring A is C 3-10C of ring A is selected from cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, and bicyclic 8- to 10-membered heterocycloalkyl; 3-7 Cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, and bicyclic 8- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0064] In some embodiments, ring A is C 3-7 C of ring A is selected from cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, and bicyclic 8- to 10-membered heterocycloalkyl; 3-7 Cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, and bicyclic 8- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0065] In some embodiments, ring A is a monocyclic C 3-7 Cycloalkyl, Bicyclic C 8-10 cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, and spirocyclic 7- to 11-membered heterocycloalkyl; and monocyclic C of ring A is 3-7 Cycloalkyl, Bicyclic C 8-10 Cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, and spirocyclic 7- to 11-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0066] In some embodiments, ring A is a monocyclic C 3-7 Cycloalkyl, Bicyclic C 8-10 cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, and spirocyclic 7- to 10-membered heterocycloalkyl; and monocyclic C of ring A is 3-7 Cycloalkyl, Bicyclic C 8-10Cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, and spirocyclic 7- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0067] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl; and each of Ring A's cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0068] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl; and each of Ring A's cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0069] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl; and wherein the cyclo of Ring A is butyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl are each optionally substituted with one, two, three, or four independently selected R 6 It is substituted by a substituent.

[0070] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl; and wherein the cyclo of Ring A is butyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl are each optionally substituted with one, two, three, or four independently selected R 6 It is substituted by a substituent.

[0071] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl, and each of the cyclobutyl, cyclopentyl, cyclohexyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl of ring A is optionally substituted with 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0072] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of Ring A's cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0073] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of Ring A's cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0074] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of Ring A's cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0075] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of Ring A's cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0076] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl, and each of the tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl of ring A is optionally substituted with 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0077] In some embodiments, Ring A is selected from tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of the tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl of Ring A is optionally substituted with 1, 2, 3, or 4 independently selected R 6It is substituted by a substituent.

[0078] In some embodiments, Ring A is selected from tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of the tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl of Ring A is optionally substituted with 1, 2, 3, or 4 independently selected R 6 It is substituted by a substituent.

[0079] In some embodiments, ring A is selected from tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl, and each of the tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl of ring A is optionally joined to one, two, three, or four independently selected R 6 It is substituted by a substituent.

[0080] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl; and cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl are each optionally substituted with one or two independently selected R 6 It is substituted by a substituent.

[0081] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl; and cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl are each optionally substituted with one or two independently selected R 6 It is substituted by a substituent.

[0082] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl, and each of the cyclobutyl, cyclopentyl, cyclohexyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl of ring A is optionally substituted with one or two independently selected R 6 It is substituted by a substituent.

[0083] In some embodiments, ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl, and each of the tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl of ring A is optionally substituted with one or two independently selected R 6 It is substituted by a substituent.

[0084] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of Ring A's cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with one or two independently selected R 6 It is substituted by a substituent.

[0085] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of Ring A's cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with one or two independently selected R 6 It is substituted by a substituent.

[0086] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of Ring A's cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with one or two independently selected R 6 It is substituted by a substituent.

[0087] In some embodiments, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, 2,3-dihydro-1H-indenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of Ring A's cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl is optionally substituted with one or two independently selected R 6 It is substituted by a substituent.

[0088] In some embodiments, ring A is selected from tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl, and each of the tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl of ring A is optionally substituted with one or two independently selected R 6 It is substituted by a substituent.

[0089] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0090] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , and C(O)OR a6 Selected from R 6C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0091] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0092] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , and C(O)OR a6 Selected from R 6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0093] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A It is substituted with a substituent.

[0094] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , and C(O)OR a6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A It is substituted with a substituent.

[0095] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-10 Cycloalkyl-C 1-6 Alkyl-, C 6-10 Aryl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R.c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 3-10 Cycloalkyl-C 1-6 Alkyl-, C 6-10 Aryl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0096] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , and C(O)OR a6 Selected from R 6 C 1-6 Alkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, (5- to 10-membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0097] In some embodiments, each R 6 independently, C 1-6 Alkyl, C1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0098] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , and C(O)OR a6 Selected from R 6 C 1-6 Alkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, (5- to 6-membered heteroaryl)-C1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0099] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A It is substituted with a substituent.

[0100] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, (5-6 membered heteroaryl)-C 1-6Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , and C(O)OR a6 Selected from R 6 C 1-6 Alkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, (5- to 6-membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A It is substituted with a substituent.

[0101] In some embodiments, each R a6 , R b6 , R c6 , and R d6 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 alkyl-, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0102] In some embodiments, each R a6 , R b6 , R c6 , and R d6 are independently H, C1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-7 Cycloalkyl, phenyl, 4- to 7-membered heterocycloalkyl-C 1-6 alkyl-, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-7 cycloalkyl, phenyl, and 4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0103] In some embodiments, each R a6 , R b6 , R c6 , and R d6 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 6A It is substituted with a substituent.

[0104] In some embodiments, each R a6 , R b6 , R c6 , and R d6 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 alkyl-, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A It is substituted with a substituent.

[0105] In some embodiments, each R a6 , R b6 , R c6 , and R d6 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-7 Cycloalkyl, phenyl, and 4- to 7-membered heterocycloalkyl-C 1-6 alkyl-, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-7 cycloalkyl, phenyl, and 4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A It is substituted with a substituent.

[0106] In some embodiments, each R a6 , R b6 , Rc6 , and R d6 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl is optionally followed by one or two independently selected R 6A It is substituted with a substituent.

[0107] In some embodiments, each R a6 , R b6 , R c6 , and R d6 are independently H, C 1-6 Alkyl, C 3-10 Cycloalkyl, C 6-10 Aryl and 4-10 membered heterocycloalkyl-C 1-6 alkyl-, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A It is substituted with a substituent.

[0108] In some embodiments, each R a6 , R b6 , R c6 , and R d6 are independently H, C 1-6 Alkyl, C 3-7 Cycloalkyl, phenyl, and 4- to 7-membered heterocycloalkyl-C 1-6 alkyl-, and R a6 , R b6 , Rc6 , and R d6 C 1-6 Alkyl, C 3-7 cycloalkyl, phenyl, and 4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A It is substituted with a substituent.

[0109] In some embodiments, each R a6 , R b6 , R c6 , and R d6 are independently H or C 1-6 alkyl, and R a6 , R b6 , R c6 , and R d6 C 1-6 Each alkyl is optionally substituted with one or two independently selected R 6A It is substituted with a substituent.

[0110] In some embodiments, each R a6 , R b6 , R c6 , and R d6 are independently H, C 1-6 R is selected from alkyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranylmethyl; a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranylmethyl are each optionally substituted with one or two independently selected R 6A It is substituted with a substituent.

[0111] In some embodiments, each R a6 , R b6 , R c6 , and R d6 is independently selected from H, methyl, ethyl, propyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranylmethyl; R a6 , R b6, R c6 , and R d6 Methyl, ethyl, propyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranylmethyl are each optionally substituted with one or two independently selected R 6A It is substituted with a substituent.

[0112] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, phenyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, phenyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A is substituted with a substituent, Each R a6 , R b6 , R c6 , and R d6 are independently H, C 1-6Alkyl, C 3-10 Cycloalkyl, C 6-10 Aryl and 4-10 membered heterocycloalkyl-C 1-6 alkyl-, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A It is substituted with a substituent.

[0113] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, phenyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, phenyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A is substituted with a substituent, Each R a6 , R b6 , R c6 , and R d6 are independently H, C 1-6 R is selected from alkyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranylmethyl; a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranylmethyl are each optionally substituted with one or two independently selected R 6A It is substituted with a substituent.

[0114] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, phenyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6Alkyl-, phenyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A is substituted with a substituent, Each R a6 , R b6 , R c6 , and R d6 is independently selected from H, methyl, ethyl, propyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranylmethyl; R a6 , R b6 , R c6 , and R d6 Methyl, ethyl, propyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranylmethyl are each optionally substituted with one or two independently selected R 6A It is substituted with a substituent.

[0115] In some embodiments, each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, phenyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C 3-7 Cycloalkyl-C 1-6 Alkyl-, phenyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 6A is substituted with a substituent, Each R a6 , R b6 , R c6 , and R d6 is independently selected from H, methyl, ethyl, propyl, cyclopropyl, cyclobutyl, phenyl, and tetrahydropyranylmethyl.

[0116] In some embodiments, each R 6 independently, C 1-6 Alkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, and C(O)R b6 Selected from R 6 C 1-6 Alkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R b6 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R b6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 6A It is substituted by a substituent.

[0117] In some embodiments, each R 6 independently, C 1-6Alkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, and C(O)R b6 Selected from R 6 C 1-6 Alkyl, 5- to 6-membered heteroaryl, and 4- to 6-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R b6 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R b6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 6A It is substituted by a substituent.

[0118] In some embodiments, each R 6 independently, C 1-6 Alkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, and C(O)R b6 Selected from R 6 C 1-6 Alkyl, 5- to 6-membered heteroaryl, and 4- to 6-membered heterocycloalkyl are each optionally joined by one or two independently selected R 6A is substituted with a substituent, Each R b6 are independently H and C 1-6 alkyl, and R b6 C 1-6 Each alkyl is optionally substituted with one or two independently selected R 6A It is substituted by a substituent.

[0119] In some embodiments, each R 6 independently, C 1-6Alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, C(O)R b6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, and bicyclo[1.1.1]pentanyl are each optionally substituted with one or two independently selected R 6A It is substituted with a substituent.

[0120] In some embodiments, each R 6 is independently selected from ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino; R 6ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1.]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino are each optionally substituted with one or two independently selected R 6A It is substituted with a substituent.

[0121] In some embodiments, each R 6 is independently selected from ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino; R 6ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, 2-azabicyclo[2.1.1]hexanyl, and bicyclo[1.1.1]pentanyl are each optionally substituted with one or two independently selected R 6A It is substituted with a substituent.

[0122] In some embodiments, each R 6 independently, C 1-6 Alkyl, pyrazolyl, piperidinyl, and C(O)R b6 Selected from R 6 C 1-6 Alkyl, pyrazolyl, and piperidinyl are each optionally joined by one or two independently selected R 6A is substituted with a substituent, Each R b6 are independently H or C 1-6 alkyl, and R b6 C 1-6 The alkyl is optionally substituted with a 5- to 6-membered heterocycloalkyl.

[0123] In some embodiments, each R 6 independently, C 1-6 Alkyl, pyrazolyl, piperidinyl, and C(O)R b6 Selected from R 6 C 1-6 Alkyl, pyrazolyl, and piperidinyl are each optionally joined by one or two independently selected R 6A is substituted with a substituent, Each R b6 are independently H or C 1-6 alkyl, and R b6 C 1-6 The alkyl is optionally substituted by tetrahydropyranyl.

[0124] In some embodiments, each R 6A independently, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, CN, C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , and OC(O)R c61 Selected from R 6A C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6B It is substituted with a substituent.

[0125] In some embodiments, each R 6A are independently phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, CN, C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , and OC(O)R c61 Selected from R 6A Phenyl, C 3-7 Cycloalkyl, 5- to 6-membered heteroaryl, and 4- to 6-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6B It is substituted with a substituent.

[0126] In some embodiments, each R 6A are independently phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, CN, C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , and OC(O)R c61 Selected from R 6A Phenyl, C 3-7Cycloalkyl, 5- to 6-membered heteroaryl, and 4- to 6-membered heterocycloalkyl are each optionally joined by one or two independently selected R 6B It is substituted with a substituent.

[0127] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 6-10 aryl, and R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 6-10 Each aryl is optionally selected from 1, 2, 3, or 4 independently selected R 6B It is substituted by a substituent.

[0128] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 6-10 aryl, R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 6-10 Each aryl is optionally selected from one or two independently selected R 6B It is substituted by a substituent.

[0129] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and phenyl; R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and phenyl each optionally contain 1, 2, 3, or 4 independently selected R 6B It is substituted by a substituent.

[0130] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and phenyl; R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl and phenyl each optionally contain one or two independently selected R 6B It is substituted by a substituent.

[0131] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 Alkyl, and C 6-10 aryl, Ra61 , R b61 , R c61 , and R d61 C 1-6 Alkyl and C 6-10 Each aryl is optionally selected from 1, 2, 3, or 4 independently selected R 6B It is substituted by a substituent.

[0132] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 Alkyl, and C 6-10 aryl, R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl and C 6-10 Each aryl is optionally selected from one or two independently selected R 6B It is substituted by a substituent.

[0133] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 alkyl, and phenyl; R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl and phenyl each optionally have 1, 2, 3, or 4 independently selected R 6B It is substituted by a substituent.

[0134] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 alkyl, and phenyl; R a61 , R b61 , R c61 , and R d61 C1-6 Alkyl and phenyl each optionally contain one or two independently selected R 6B It is substituted by a substituent.

[0135] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, and R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 6B It is substituted by a substituent.

[0136] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H and C 1-6 alkyl, and R a61 , R b61 , R c61 , and R d61 C 1-6 Each alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 6B It is substituted by a substituent.

[0137] In some embodiments, each R a61 , R b61 , R c61 , and R d61 are independently H and C 1-6 alkyl, and R a61 , R b61 , R c61 , and R d61 C 1-6Each alkyl is optionally substituted with one or two independently selected R 6B It is substituted by a substituent.

[0138] In some embodiments, each R a61 , R b61 , R c61 , and R d61 is independently selected from H, methyl, ethyl, and phenyl.

[0139] In some embodiments, each R 6A are independently halo, oxo, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, CN, OR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , N.R. c61 S(O)2R b61 , and S(O)2R b61 Selected from R 6A Each C 1-6 Alkyl and 4- to 10-membered heterocycloalkyl optionally contain 1, 2, 3, or 4 independently selected R 6B It is substituted with a substituent.

[0140] In some embodiments, each R 6A are independently halo, oxo, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, CN, OR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NRc61 R d61 , N.R. c61 S(O)2R b61 , and S(O)2R b61 Selected from R 6A Each C 1-6 Alkyl and 4- to 10-membered heterocycloalkyl optionally contain 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 Alkyl, and C 6-10 aryl, R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl and C 6-10 Each aryl is optionally selected from one or two independently selected R 6B It is substituted by a substituent.

[0141] In some embodiments, each R 6A are independently halo, oxo, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, CN, OR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , N.R. c61 S(O)2R b61 , and S(O)2R b61 Selected from R 6A Each C 1-6 Alkyl and 4- to 10-membered heterocycloalkyl optionally contain 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, In some embodiments, each Ra61 , R b61 , R c61 , and R d61 are independently H, C 1-6 Alkyl, and C 6-10 aryl, R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl and C 6-10 Each aryl is optionally selected from one or two independently selected R 6B It is substituted by a substituent.

[0142] In some embodiments, each R 6A are independently halo, oxo, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, CN, OR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , N.R. c61 S(O)2R b61 , and S(O)2R b61 Selected from R 6A Each C 1-6 Alkyl and 4- to 10-membered heterocycloalkyl optionally contain 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R a61 , R b61 , R c61 , and R d61 are independently H, C 1-6 alkyl, and phenyl; R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl and phenyl each optionally contain one or two independently selected R 6BIt is substituted by a substituent.

[0143] In some embodiments, each R 6A are independently halo, oxo, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, CN, OR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , N.R. c61 S(O)2R b61 , and S(O)2R b61 Selected from R 6A Each C 1-6 Alkyl and 4- to 10-membered heterocycloalkyl optionally contain 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R a61 , R b61 , R c61 , and R d61 is independently selected from H, methyl, ethyl, and phenyl.

[0144] In some embodiments, each R 6A are independently 4 to 10 membered heterocycloalkyl, CN, and C(O)R b61 Selected from R 6A Each 4- to 10-membered heterocycloalkyl optionally has 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R b61 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R b61 C 1-6 Alkyl, C 1-6 Haloalkyl, C2-6 Alkenyl, C 2-6 Each alkynyl is optionally followed by one or two independently selected R 6B It is substituted by a substituent.

[0145] In some embodiments, each R 6A are independently 4- to 6-membered heterocycloalkyl, CN, and C(O)R b61 Selected from R 6A each 4- to 6-membered heterocycloalkyl optionally being selected from 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R b61 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R b61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl is optionally followed by one or two independently selected R 6B It is substituted by a substituent.

[0146] In some embodiments, each R 6A are independently 4- to 6-membered heterocycloalkyl, CN, and C(O)R b61 Selected from R 6A Each 4- to 6-membered heterocycloalkyl optionally contains one or two independently selected R 6B is substituted with a substituent, Each R b61 are independently H and C 1-6 alkyl, and R b61 C 1-6 Each alkyl is optionally substituted with one or two independently selected R 6B It is substituted by a substituent.

[0147] In some embodiments, each R 6B independently, C 1-6Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, and C(O)NR c62 R d62 Selected from R 6B C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 6C It is substituted by a substituent.

[0148] In some embodiments, each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, and R 6B C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 6C It is substituted by a substituent.

[0149] In some embodiments, each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, and C(O)NR c62 R d62 Selected from R 6B C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally followed by one or two independently selected R 6C is substituted by a substituent, Each R c62 and R d62 are independently H or C 1-6It is alkyl.

[0150] In some embodiments, each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, and C(O)NR c62 R d62 Selected from R 6B C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally followed by one or two independently selected R 6C is substituted by a substituent, Each R c62 and R d62 are independently H or C 1-3 It is alkyl.

[0151] In some embodiments, each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, and R 6B C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally followed by one or two independently selected R 6C It is substituted by a substituent.

[0152] In some embodiments, each R 6C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 It is selected from alkynyl, CN, and NO2.

[0153] In some embodiments, each R 6C independently, halo, C1-6 Alkyl, C 1-6 It is selected from haloalkyl, CN, and NO2.

[0154] In some embodiments, each R 6C is CN.

[0155] In some embodiments, each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, and C(O)NR c62 R d62 Selected from C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally substituted by CN.

[0156] In some embodiments, each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally substituted by CN.

[0157] In some embodiments, each R 6B independently, C 1-6 Alkyl, CN, and C(O)NR c62 R d62 Selected from R 6B C 1-6 Each alkyl is optionally substituted by CN, and each R c62 and R c62 are independently H and C 1-3 alkyl.

[0158] In some embodiments, each R 6B independently, C 1-6 alkyl, CN, and C(O)NH; R 6B C 1-6 Each alkyl is optionally substituted by CN.

[0159] In some embodiments, each R 6B independently, C 1-6 alkyl, and R 6B C 1-6 Each alkyl is optionally substituted by CN.

[0160] In some embodiments, each R 6B are independently selected from methyl, CN, and C(O)NH; R 6B Each methyl in is optionally substituted by CN.

[0161] In some embodiments, each R 6C is CN.

[0162] In some embodiments, each R 6A is independently selected from fluoro, oxo, methyl, CN, methoxy, tetrahydropyranyl, methylcarbonyl, aminocarbonyl, methylcarbonylamino, ethylaminocarbonyl, methoxycarbonyl, methoxycarbonylamino, ethylaminocarbonyl, ethylsulfonyl, and phenylsulfonylamino; R 6A each methyl in is optionally substituted by CN or aminocarbonyl, and R 6A is optionally substituted by cyanomethyl.

[0163] In some embodiments, each R 6Ais independently selected from fluoro, oxo, methyl, CN, cyanomethyl, methoxy, tetrahydropyranyl, cyanomethyltetrahydropyranyl, methylcarbonylamino, aminocarbonyl, methylcarbonylamino, ethylaminocarbonyl, methoxycarbonylamino, methoxycarbonylamino, ethylaminocarbonylamino, ethylsulfonyl, and phenylsulfonylamino.

[0164] In some embodiments, each R 6A is independently selected from cyano, tetrahydropyranyl, cyanomethyltetrahydropyranyl, and methylcarbonyl.

[0165] In some embodiments, R 2 is H, C 1-6 Alkyl, C 2-6 Alkenyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0166] In some embodiments, R 2 is C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 2 C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0167] In some embodiments, R 2 is H, C 1-6 Alkyl, C 2-6 Alkenyl, phenyl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 2 C 1-6 Alkyl, C 2-6 Alkenyl, phenyl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, phenyl-C1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 2A It is substituted with a substituent.

[0168] In some embodiments, R 2 is phenyl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 2 Phenyl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 2A It is substituted with a substituent.

[0169] In some embodiments, R 2 is H, C 1-6 Alkyl, C 2-6 Alkenyl, C 6-10 aryl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R 2 C 1-6 Alkynyl, C 2-6 Alkenyl, C 6-10Aryl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0170] In some embodiments, R 2 is C 6-10 aryl and 5- to 10-membered heteroaryl; R 2 C 6-10 The aryl and 5- to 10-membered heteroaryl each optionally contain 1, 2, 3, or 4 independently selected R 2A It is substituted by a substituent.

[0171] In some embodiments, R 2 is H, C 1-6 Alkyl, C 2-6 Alkenyl, phenyl, C 3-10 cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R 2 Phenyl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0172] In some embodiments, R 2 is phenyl, C 3-10 cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R 2 Phenyl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0173] In some embodiments, R 2 is H, C 1-6 Alkyl, C 2-6alkenyl, phenyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R 2 C 1-6 Alkyl, C 2-6 Alkenyl, phenyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl each optionally have 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0174] In some embodiments, R 2 is selected from phenyl and 5- to 10-membered heteroaryl; R 2 The phenyl and 5- to 10-membered heteroaryl each optionally contain 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0175] In some embodiments, R 2 is H, C 1-6 Alkyl, C 2-6 R is selected from alkenyl, phenyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, and monocyclic 4- to 6-membered heterocycloalkyl; 2 C 1-6 Alkyl, C 2-6 Alkenyl, phenyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, and monocyclic 4- to 6-membered heterocycloalkyl each optionally have 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0176] In some embodiments, R 2 is selected from phenyl and 8- to 10-membered heteroaryl; R 2 The phenyl and 5- to 10-membered heteroaryl each optionally contain 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0177] In some embodiments, R 2 is H, C 1-6 Alkyl, C 2-6R is selected from alkenyl, phenyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, and monocyclic 4- to 6-membered heterocycloalkyl; 2 C 1-6 Alkyl, C 2-6 Alkenyl, phenyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, and monocyclic 4- to 6-membered heterocycloalkyl each optionally contain one or two independently selected R 2A It is substituted with a substituent.

[0178] In some embodiments, R 2 is selected from phenyl and 8- to 10-membered heteroaryl; R 2 The phenyl and 5- to 10-membered heteroaryl may each optionally be one or two independently selected R 2A It is substituted with a substituent.

[0179] In some embodiments, R 2 is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R 2 ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl are each optionally selected from 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0180] In some embodiments, R 2 is selected from phenyl and indazolyl; R 2 The phenyl and indazolyl in each optionally contain 1, 2, 3, or 4 independently selected R 2A It is substituted with a substituent.

[0181] In some embodiments, R 2is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R 2 ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl are each optionally substituted with one or two independently selected R 2A It is substituted with a substituent.

[0182] In some embodiments, R 2 is selected from phenyl and indazolyl; R 2 The phenyl and indazolyl in each of the groups may optionally be substituted with one or two independently selected R 2A It is substituted with a substituent.

[0183] In some embodiments, each R 2A independently, halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, (4- to 10-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0184] In some embodiments, each R 2A independently, C 1-6 Alkyl, C1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0185] In some embodiments, each R 2A independently, halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, (4- to 6-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-6 Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0186] In some embodiments, each R 2A independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C3-7 cycloalkyl, 5- to 6-membered heteroaryl, and 4- to 6-membered heterocycloalkyl; R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-6 Cycloalkyl, 5- to 6-membered heteroaryl, and 4- to 6-membered heterocycloalkyl are each optionally joined by 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0187] In some embodiments, each R 2A independently, halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, (4- to 6-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-6 Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 2B It is substituted with a substituent.

[0188] In some embodiments, each R 2A independently, halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, (4- to 6-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, and OR a21Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-6 Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 2B is substituted with a substituent, Each R a21 are independently H, C 1-6 Alkyl, and C 1-6 haloalkyl.

[0189] In some embodiments, each R 2A independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 cycloalkyl, 5- to 6-membered heteroaryl, and 4- to 6-membered heterocycloalkyl; R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-6 Cycloalkyl, 5- to 6-membered heteroaryl, and 4- to 6-membered heterocycloalkyl are each optionally joined by one or two independently selected R 2B It is substituted with a substituent.

[0190] In some embodiments, each R 2A independently, halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, (4- to 10-membered heterocycloalkyl)-C 1-6 Alkyl, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10Cycloalkyl, 5- to 10-membered heteroaryl, and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0191] In some embodiments, each R 2A independently, C 1-6 alkyl and 5- to 10-membered heteroaryl; R 2A C 1-6 The alkyl and 5- to 10-membered heteroaryl each optionally have 1, 2, 3, or 4 independently selected R 2B It is substituted with a substituent.

[0192] In some embodiments, each R 2A independently, halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, (4- to 10-membered heterocycloalkyl)-C 1-6 Alkyl, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl is optionally substituted with one or two independently selected R 2B It is substituted with a substituent.

[0193] In some embodiments, each R 2A independently, C 1-6 alkyl and 5- to 10-membered heteroaryl; R 2A C 1-6 The alkyl and 5- to 10-membered heteroaryl are each optionally joined by one or two independently selected R 2B It is substituted with a substituent.

[0194] In some embodiments, each R 2Aindependently, halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 5-6 membered heteroaryl, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 5- to 6-membered heteroaryl, and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl is optionally substituted with one or two independently selected R 2B It is substituted with a substituent.

[0195] In some embodiments, each R 2A independently, halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 5-6 membered heteroaryl, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-6 Cycloalkyl, 5- to 6-membered heteroaryl, and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl is optionally substituted with one or two independently selected R 2B It is substituted with a substituent. Each R a21 are independently H, C 1-6 Alkyl, and C 1-6 haloalkyl.

[0196] In some embodiments, each R 2A independently, C 1-6 alkyl and 5- to 6-membered heteroaryl; R 2A C 1-6 The alkyl and 5- to 6-membered heteroaryl are each optionally joined by one or two independently selected R 2BIt is substituted with a substituent.

[0197] In some embodiments, each R 2A are independently selected from fluoro, methyl, CD3, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy, and methyl, cyclopropyl, pyrazolyl, and piperazinylmethyl are each optionally coupled to one or two independently selected R 2B It is substituted with a substituent.

[0198] In some embodiments, each R 2A are independently selected from methyl and pyrazolyl, each of which is optionally followed by one or two independently selected R 2B It is substituted with a substituent.

[0199] In some embodiments, each R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, S(O)R b22 , and S(O)2R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 2C It is substituted with a substituent.

[0200] In some embodiments, each R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and S(O)R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 2C It is substituted with a substituent.

[0201] In some embodiments, each R a22 , R b22 , R c22 , and R d22 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl.

[0202] In some embodiments, each R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and S(O)R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R b22 are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl.

[0203] In some embodiments, each R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and S(O)R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R b22 are independently H or C 1-6 alkyl.

[0204] In some embodiments, each R 2B independently, halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, and R 2B C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 2C It is substituted with a substituent.

[0205] In some embodiments, each R 2B independently, C 1-6 Alkyl and S(O)R b22 Selected from R 2B C 1-6 Each alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 2C It is substituted with a substituent.

[0206] In some embodiments, each R 2B independently, C 1-6 Alkyl and S(O)R b22 Selected from R 2B C 1-6 Each alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R b22 are independently H or C 1-6 alkyl.

[0207] In some embodiments, each R 2B independently, C 1-6 alkyl, and R2B C 1-6 Each alkyl is optionally selected from 1, 2, 3, or 4 independently selected R 2C It is substituted with a substituent.

[0208] In some embodiments, each R 2B independently, C 1-6 Alkyl and S(O)R b22 Selected from R 2B C 1-6 Each alkyl is optionally substituted with one or two independently selected R 2C It is substituted with a substituent.

[0209] In some embodiments, each R 2B independently, C 1-6 Alkyl and S(O)R b22 Selected from R 2B C 1-6 Each alkyl is optionally substituted with one or two independently selected R 2C is substituted with a substituent, Each R b22 are independently H or C 1-6 alkyl.

[0210] In some embodiments, each R 2B independently, C 1-6 alkyl, and R 2B C 1-6 Each alkyl is optionally substituted with one or two independently selected R 2C It is substituted with a substituent.

[0211] In some embodiments, each R 2C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 It is selected from alkynyl, CN, and NO2.

[0212] In some embodiments, each R 2C independently, halo, C1-6 Alkyl, C 1-6 It is selected from haloalkyl, CN, and NO2.

[0213] In some embodiments, each R 2C is CN.

[0214] In some embodiments, each R 2B are independently cyanoisopropyl and S(O)R b22 Each R b22 are independently H and C 1-6 alkyl.

[0215] In some embodiments, each R 2B is independently selected from cyanomethyl and methylsulfonyl.

[0216] In some embodiments, each R 2A is independently selected from fluoro, methyl, CD3, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy; R 2A wherein methyl and pyrazolyl are each optionally cyano-C 1-6 substituted by alkyl, R 2A The piperazinylmethyl of the formula is optionally S(O)R b22 is replaced by Each R b22 are independently H or C 1-6 alkyl.

[0217] In some embodiments, each R 2A is independently selected from fluoro, methyl, CD3, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy; R 2A wherein the methyl and pyrazolyl are each optionally cyano-C 1-6 is substituted by alkyl, and R 2A The piperazinylmethyl in is optionally substituted with methylsulfonyl.

[0218] In some embodiments, each R 2A is independently selected from fluoro, methyl, CD3, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy; R 2A The pyrazolyl in R is optionally substituted by cyanoisopropyl; 2A The piperazinylmethyl in is optionally substituted with methylsulfonyl.

[0219] In some embodiments, each R 2A is independently selected from methyl and pyrazolyl, each of which is optionally selected from cyano-C 1-6 It is substituted by alkyl.

[0220] In some embodiments, R 2 is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R 2 and indazolyl are each optionally substituted with one or two R independently selected from fluoro, methyl, CD, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy. 2A is substituted with a substituent, R 2A wherein the methyl and pyrazolyl are each optionally cyano-C 1-6 is substituted by alkyl, and R 2A The piperazinylmethyl in is optionally substituted with methylsulfonyl.

[0221] In some embodiments, R 2 is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R 2and indazolyl are each optionally substituted with one or two R independently selected from fluoro, methyl, CD, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy. 2A is substituted with a substituent, R 2A wherein the methyl and pyrazolyl are each optionally cyano-C 1-6 is substituted by alkyl, and R 2A The piperazinylmethyl in is optionally substituted with methylsulfonyl.

[0222] In some embodiments, R 2 is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R 2 and indazolyl are each optionally substituted with one or two R independently selected from fluoro, methyl, CD, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy. 2A is substituted with a substituent, R 2A Each of the methyl and pyrazolyl in R is optionally substituted by cyanoisopropyl; 2A The piperazinylmethyl in is optionally substituted with methylsulfonyl.

[0223] In some embodiments, R 2 is selected from phenyl and indazolyl; R 2 The phenyl and indazolyl each optionally have one or two R selected from fluoro, methyl, CD, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy. A is substituted with a substituent, R 2A wherein the pyrazolyl is optionally substituted by cyanoisopropyl; R 2AThe piperazinylmethyl in is optionally substituted with methylsulfonyl.

[0224] In some embodiments, R 2 is selected from phenyl, methylindazolyl, and trideuteromethylindazolyl; R 2 The phenyl optionally has one or two R selected from fluoro, methyl, CD, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy. 2A is substituted with a substituent, R 2A wherein the pyrazolyl is optionally substituted by cyanoisopropyl; R 2A The piperazinylmethyl in is optionally substituted with methylsulfonyl.

[0225] In some embodiments, R 2 is selected from phenyl and indazolyl; R 2 The phenyl and indazolyl in each of the groups may optionally be substituted with one or two R independently selected from methyl and pyrazolyl. 2A is substituted with a substituent, R 2A wherein the methyl and pyrazolyl are each optionally cyano-C 1-6 It is substituted by alkyl.

[0226] In some embodiments, R 2 is selected from methylindazolyl and trideuteromethylindazolyl.

[0227] In some embodiments, R 3 is C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3 C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0228] In some embodiments, R 3 is phenyl, C 3-7 Cycloalkyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3 Phenyl, C 3-7 Cycloalkyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0229] In some embodiments, R 3 is phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3 Phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0230] In some embodiments, R 3 is phenyl, C 3-7 Cycloalkyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3 Phenyl, C 3-7 Cycloalkyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl, (5-6 membered heteroaryl)-C1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 3A It is substituted with a substituent.

[0231] In some embodiments, R 3 is phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3 Phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 3A It is substituted with a substituent.

[0232] In some embodiments, R 3 is C 6-10 Aryl, C 3-10 cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R 3 C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0233] In some embodiments, R 3 is C6-10 Aryl, C 3-10 cycloalkyl, and 5- to 10-membered heteroaryl; R 3 C 6-10 Aryl, C 3-10 The cycloalkyl and 5- to 10-membered heteroaryl each optionally contain 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0234] In some embodiments, R 3 is phenyl, C 3-7 cycloalkyl, monocyclic 5-6 membered heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl; R 3 Phenyl, C 3-7 Cycloalkyl, monocyclic 5-6 membered heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0235] In some embodiments, R 3 is phenyl, C 3-7 cycloalkyl, and 5- to 6-membered heteroaryl; R 3 Phenyl, C 3-7 The cycloalkyl and 5- to 6-membered heteroaryl each optionally contain 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0236] In some embodiments, R 3 is phenyl, C 3-7 cycloalkyl, monocyclic 5-6 membered heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl; R 3 Phenyl, C 3-7 Cycloalkyl, monocyclic 5-6 heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl each optionally contain one or two independently selected R 3AIt is substituted with a substituent.

[0237] In some embodiments, R 3 is phenyl, C 3-7 cycloalkyl, and 5- to 6-membered heteroaryl; R 3 Phenyl, C 3-7 The cycloalkyl and 5- to 6-membered heteroaryl are each optionally joined by one or two independently selected R 3A It is substituted with a substituent.

[0238] In some embodiments, R 3 is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl; R 3 phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0239] In some embodiments, R 3 is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl; R 3phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally substituted with one or two independently selected R 3A It is substituted with a substituent.

[0240] In some embodiments, R 3 is selected from phenyl, cyclopropyl, and pyrazolyl; R 3 Each of the phenyl, cyclopropyl, and pyrazolyl groups is optionally selected from 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0241] In some embodiments, R 3 is selected from phenyl, cyclopropyl, and pyrazolyl; R 3 The phenyl and pyrazolyl in each of the groups optionally have 1, 2, 3, or 4 independently selected R 3A It is substituted with a substituent.

[0242] In some embodiments, R 3 is selected from phenyl, cyclopropyl, and pyrazolyl; R 3 Each of the phenyl and pyrazolyl groups may optionally be selected from one or two independently selected R 3A It is substituted with a substituent.

[0243] In some embodiments, each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0244] In some embodiments, each R a31 , R b31 , R c31 , and R d31 are independently H, C 1-6 alkyl, and 4- to 10-membered heterocycloalkyl.

[0245] In some embodiments, each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R a31 , R b31 , R c31 , and R d31 are independently H, C 1-6 alkyl, and 4- to 10-membered heterocycloalkyl.

[0246] In some embodiments, each R a31 , R b31 , R c31 , and R d31 are independently H, C 1-6 alkyl, and 4- to 6-membered heterocycloalkyl.

[0247] In some embodiments, each R a31 , R b31 , R c31 , and R d31 are independently H, C 1-6 alkyl, and 4- to 6-membered heterocycloalkyl.

[0248] In some embodiments, each R a31 , R b31 , R c31 , and R d31 are independently H, C 1-3 alkyl, and 4- to 6-membered heterocycloalkyl.

[0249] In some embodiments, each R a31 , R b31 , R c31 , and R d31 is independently selected from H, methyl, ethyl, and morpholinyl.

[0250] In some embodiments, each R 3A are independently H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0251] In some embodiments, each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0252] In some embodiments, each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R a31 , R b31 , R c31 , and R d31 are independently H, C 1-6 alkyl, and 4- to 10-membered heterocycloalkyl.

[0253] In some embodiments, each R 3A independently, C 1-6 Alkyl, C 1-6Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0254] In some embodiments, each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31, and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 3B It is substituted with a substituent.

[0255] In some embodiments, each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 3B is substituted with a substituent, Each R b31 , R c31 , and R d31 are independent, H, C 1-6 alkyl, and 4- to 10-membered heterocycloalkyl.

[0256] In some embodiments, each R 3A independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 3B It is substituted with a substituent.

[0257] In some embodiments, each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 3-10 Cycloalkyl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0258] In some embodiments, each R 3A independently, C 1-6 Alkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0259] In some embodiments, each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 3-7 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0260] In some embodiments, each R 3A independently, C 1-6 Alkyl, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0261] In some embodiments, each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 3-7 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 3B It is substituted with a substituent.

[0262] In some embodiments, each R 3A independently, C 1-6 Alkyl, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally replaced by one or two independently selected R 3B It is substituted with a substituent.

[0263] In some embodiments, each R 3B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, OR a32 , C(O)R b32 , C(O)NR c32 R d32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , S(O)NR c32 R d32 Each R a32 , R b32 , R c32 , and R d32 are independently H and C 1-6 alkyl.

[0264] In some embodiments, each R 3B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C(O)R b32 , C(O)NR c32 R d32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , S(O)NR c32 R d32 Each R a32 , R b32 , R c32 , and R d32 are independently H and C 1-6 alkyl.

[0265] In some embodiments, each R 3B are independently CN, OR a32 , C(O)R b32 , S(O)R b32 , S(O)NRc32 R d32 , S(O)2R b32 , and S(O)NR c32 R d32 Each R a32 , R b32 , R c32 , and R d32 are independently H and C 1-6 alkyl.

[0266] In some embodiments, each R 3B are independent of each other, S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , and S(O)NR c32 R d32 Each R a32 , R b32 , R c32 , and R d32 are independently H and C 1-6 alkyl.

[0267] In some embodiments, each R 3B are independently CN, OR a32 , C(O)R b32 , and S(O)2R b32 Each R a32 and R b32 are independently H and C 1-6 alkyl.

[0268] In some embodiments, each R 3B are independently S(O)2R b32 Each R b32 are independently H and C 1-6 alkyl.

[0269] In some embodiments, each R 3B is independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano.

[0270] In some embodiments, each R 3Bis independently selected from methylsulfonyl.

[0271] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3A methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 3B It is substituted with a substituent.

[0272] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3A methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally substituted with one or two independently selected R3B It is substituted with a substituent.

[0273] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3A wherein methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano.

[0274] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3Awherein methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally substituted with one or two substituents independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano.

[0275] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), methylpyridyl, methylpiperidinyl, pyridylmethyl, and piperidinylmethyl; R 3A wherein the methylpyridyl, methylpiperidinyl, pyridylmethyl, and piperidinylmethyl are each optionally substituted by methylsulfonyl.

[0276] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), pyridylmethyl, and piperidinylmethyl; R 3A wherein each of the pyridylmethyl and piperidinylmethyl is optionally substituted by methylsulfonyl.

[0277] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), methylpyridyl, and methylpiperidinyl; R 3A wherein the methylpyridyl and methylpiperidinyl are each optionally substituted by methylsulfonyl.

[0278] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), methylpyridyl, and methylpiperidinyl; R 3A Each methylpiperidinyl in is optionally substituted by methylsulfonyl.

[0279] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3A wherein methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally substituted with one or two substituents independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano.

[0280] In some embodiments, each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), isopropyl, difluoroethyl, trifluoroethyl, methoxyethyl, hydroxymethylpropyl, hydroxyisobutyl, methoxyisobutyl, methoxy, cyclopropyl, cyclopentyl, (cyanophenyl)methyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, cyclopropylmethyl, cyclopropylethyl, tetrahydrofuranyl, tetrahydropyranyl, methylcarbonylpiperidinyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3A wherein each of the pyridylmethyl and piperidinylmethyl is optionally substituted by methylsulfonyl.

[0281] In some embodiments, R 3is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl; R 3 phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3A wherein methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally substituted with one or two substituents independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano.

[0282] In some embodiments, R 3is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl; R 3 phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally substituted with one or two independently selected R 3A is substituted with a substituent, Each R 3A is independently selected from methyl, trideuteromethyl (i.e., -CD3), ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3A wherein methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally substituted with one or two substituents independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano.

[0283] In some embodiments, R 3is selected from phenyl, cyclopropyl, and pyrazolyl; R 3 The phenyl, cyclopropyl, and pyrazolyl in each of the formula (I) and (II) may optionally be selected from methyl, trideuteromethyl, methylpyridyl, and methylpiperidinyl. 3A is substituted with a substituent, R 3A wherein the methylpyridyl and methylpiperidinyl are each optionally substituted by methylsulfonyl.

[0284] In some embodiments, R 4 is H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, OH, NH2, and NHC 1-6 alkyl, C 1-6 The alkyl is optionally substituted with OH, CN, and NH; R 4 Each hydrogen atom of (e.g., R 4 H or R 4 C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, OH, NH2, and NHC 1-6 Each hydrogen in an alkyl is optionally replaced by a deuterium atom.

[0285] In some embodiments, R 4 is H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, and C 1-6 haloalkoxy.

[0286] In some embodiments, R 4 is H and C 1-6 alkyl.

[0287] In some embodiments, R 4 is H.

[0288] In some embodiments, R 4 is C 1-6 It is alkyl.

[0289] In some embodiments, R 4 is C 1-3 It is alkyl.

[0290] In some embodiments, R 4 is methyl or CD3.

[0291] In some embodiments, R 4 is methyl.

[0292] In some embodiments, R 4 is CD3.

[0293] In some embodiments, R 5 But, H, Halo, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, OH, CN, C(O)OH, C(O)NHR a5 , NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; R a5 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, OH, NH2, and NHC 1-6 alkyl, C 1-6 alkyl is optionally substituted with OH, CN, and NH; R 5 and R a5 Each hydrogen atom of (e.g., R 5 H or R 5 C 1-6 Alkyl, C1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, C 2-6 Alkynyl, OH, C(O)OH, C(O)NHR a5 NH2 and NHC 1-6 Each hydrogen in an alkyl is optionally replaced by a deuterium atom.

[0294] In some embodiments, R 5 is H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, and C 2-6 alkynyl.

[0295] In some embodiments, R 5 is H and C 1-6 alkyl.

[0296] In some embodiments, R 5 is H and C 1-3 alkyl.

[0297] In some embodiments, R 5 is H.

[0298] In some embodiments, R 4 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, and C 1-6 haloalkoxy; R 5 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, and C 2-6 alkynyl.

[0299] In some embodiments, R 4 is H and C 1-6 alkyl, R 5 is H and C 1-6 alkyl.

[0300] In some embodiments, R 4 is H and C 1-3 alkyl, R 5 is H and C 1-3 alkyl.

[0301] In some embodiments, R 4 is C 1-6 alkyl, and R 5 is H.

[0302] In some embodiments, R 4 is C 1-3 alkyl, and R 5 is H.

[0303] In some embodiments, R 4 is methyl or CD3, and R 5 is H.

[0304] In some embodiments, R 4 is methyl and R 5 is H.

[0305] In some embodiments, R 4 is CD3 and R 5 is H.

[0306] In some embodiments, each R M are independently H, OH, halo, oxo, CN, C(O)OH, C(O)NH2, C(O)NH(C 1-4 alkyl), C(O)N(C 1-6 alkyl)2, NH2, NO2, SF5, C1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 alkyl-, R M Each hydrogen atom of (e.g., R M H or R M OH, C(O)OH, C(O)NH2, C(O)NH(C 1-4 alkyl), C(O)N(C 1-6 alkyl)2, NH2, NH2, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkoxy, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each hydrogen in alkyl- is optionally replaced by a deuterium atom.

[0307] In some embodiments, W is C(R W )2, Y is C(R Y )2, Each R W are independently H or C 1-6is alkyl, Each R Y are independently H or C 1-6 is alkyl, Ring A is C 3-10 cycloalkyl or 4- to 11-membered heterocycloalkyl, and C of ring A 3-10 The cycloalkyl and 4- to 11-membered heterocycloalkyl each optionally have 1, 2, 3, or 4 independently selected R 6 is substituted with a substituent, R 2 But H, C 1-6 Alkyl, C 2-6 Alkenyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R 2A independently, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, (4- to 10-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2B is substituted with a substituent, Each R a21 are independent, H, C 1-6 Alkyl, and C 1-6 haloalkyl; Each R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, S(O)R b22 , and S(O)2R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R b22 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, Each R 2C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 selected from alkynyl, CN, and NO2; R 3 But C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3 C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R a31 , R b31 , R c31 , and R d31 are independent, H, C 1-6 alkyl, and 4- to 10-membered heterocycloalkyl; Each R 3B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, OR a32 , C(O)R b32 , C(O)NR c32 R d32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , S(O)NR c32 R d32 is selected from Each R a32 , R b32 , R c32 , and R d32 are independently H and C 1-6 alkyl, R 4 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, and C1-6 haloalkoxy; R 5 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, and C 2-6 alkynyl, Each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R a6 , R b6 , R c6 , and R d6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 alkyl-, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R 6A are independently halo, oxo, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, CN, OR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , N.R. c61 S(O)2R b61 , and S(O)2R b61 Selected from R 6A Each C 1-6The alkyl and 4- to 10-membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R a61 , R b61 , R c61 , and R d61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 6-10 aryl, R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 6-10 Each aryl is optionally selected from 1, 2, 3, or 4 independently selected R 6B is substituted by a substituent, Each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, and C(O)NR c62 R d62 Selected from R 6B C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 6C is substituted by a substituent, Each R c62 and R d62 are independently H or C 1-6 is alkyl, Each R 6C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6It is selected from alkynyl, CN, and NO2.

[0308] In some embodiments, W is C(R W )2, Y is C(R Y )2, Each R W are independently H or C 1-6 is alkyl, Each R Y are independently H or C 1-6 is alkyl, Ring A is C 3-10 cycloalkyl or 4- to 10-membered heterocycloalkyl, and C of ring A 3-10 The cycloalkyl and 4- to 10-membered heterocycloalkyl each optionally have 1, 2, 3, or 4 independently selected R 6 is substituted with a substituent, R 2 But H, C 1-6 Alkyl, C 2-6 Alkenyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 2 C 1-6 Alkyl, C 2-6 Alkenyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R 2A independently, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, (4- to 10-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2B is substituted with a substituent, Each R a21 are independent, H, C 1-6 Alkyl, and C 1-6 haloalkyl; Each R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, S(O)R b22 , and S(O)2R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R b22 are independent, H, C 1-6 Alkyl, C1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, Each R 2C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 selected from alkynyl, CN, and NO2; R 3 But C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3 C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R a31 , R b31 , R c31 , and R d31 are independent, H, C 1-6 alkyl, and 4- to 10-membered heterocycloalkyl; Each R 3B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, OR a32 , C(O)R b32 , C(O)NR c32 R d32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , S(O)NR c32 R d32 is selected from Each R a32 , R b32 , R c32 , and R d32 are independently H and C 1-6 alkyl, R 4 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, and C 1-6 haloalkoxy; R 5 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, and C 2-6 alkynyl, Each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R a6 , R b6 , R c6 , and R d6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 alkyl-, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-10 Cycloalkyl, C 6-10 Aryl, and 4-10 membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R 6A are independently halo, oxo, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, CN, OR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , N.R. c61 C(O)R b61 , N.R.c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , N.R. c61 S(O)2R b61 , and S(O)2R b61 Selected from R 6A Each C 1-6 The alkyl and 4- to 10-membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R a61 , R b61 , R c61 , and R d61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 6-10 aryl, R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and C 6-10 Each aryl is optionally selected from 1, 2, 3, or 4 independently selected R 6B is substituted by a substituent, Each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, CN, and C(O)NR c62 R d62 Selected from R 6B C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 6C is substituted by a substituent, Each Rc62 and R d62 are independently H or C 1-6 is alkyl, Each R 6C are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 It is selected from alkynyl, CN, and NO2.

[0309] In some embodiments, W is C(R W )2, Y is C(R Y )2, Each R W are independently H or C 1-6 is alkyl, Each R Y are independently H or C 1-6 is alkyl, Ring A is C 3-10 cycloalkyl or 4- to 10-membered heterocycloalkyl, and C of ring A 3-10 The cycloalkyl and 4- to 10-membered heterocycloalkyl each optionally have 1, 2, 3, or 4 independently selected R 6 is substituted with a substituent, R 2 But H, C 1-6 Alkyl, C 2-6 Alkenyl, C 6-10 aryl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R 2 C 1-6 Alkynyl, C 2-6 Alkenyl, C 6-10 Aryl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl are each optionally joined by 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R 2A independently, Halo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6Alkynyl, phenyl, C 3-7 Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, (4- to 6-membered heterocycloalkyl)-C 1-6 Alkyl-, CN, and OR a21 Selected from R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-6 Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2B is substituted with a substituent, Each R a21 are independent, H, C 1-6 Alkyl, and C 1-6 haloalkyl; Each R 2B are independently halo, oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, and S(O)R b22 Selected from R 2B C 1-6 Alkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 2C is substituted with a substituent, Each R b22 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, Each R 2C independently, Halo, C 1-6 Alkyl, C 1-6 selected from haloalkyl, CN, and NO2; R 3 But phenyl, C 3-7cycloalkyl, monocyclic 5-6 membered heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl; R 3 Phenyl, C 3-7 Cycloalkyl, monocyclic 5-6 membered heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl are each optionally represented by 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A are independently oxo, C 1-6 Alkyl, C 1-6 Haloalkyl, C 3-7 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4-6 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b31 , C(O)NR c31 R d31 , N.R. c31 R d31 , and S(O)2R b31 Selected from R 3A C 1-6 Alkyl, C 3-7 Cycloalkyl, 4-6 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-6 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 6-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R b31 , R c31 , and R d31 are independent, H, C 1-6 alkyl, and 4- to 10-membered heterocycloalkyl; Each R 3B Independently, CN, ORa32 , C(O)R b32 , S(O)R b32 , S(O)NR c32 R d32 , S(O)2R b32 , and S(O)NR c32 R d32 is selected from Each R a32 , R b32 , R c32 , and R d32 are independently H and C 1-6 alkyl, R 4 However, H and C 1-6 alkyl, R 5 However, H and C 1-6 alkyl, Each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C 1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl-, (4- to 7-membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , C(O)OR a6 , N.R. c6 C(O)R b6 , N.R. c6 S(O)2R b6 , and S(O)2R b6 Selected from R 6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, phenyl, C 3-7 Cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-6 Alkyl-, C 3-7 Cycloalkyl-C 1-6 Alkyl-, (5-6 membered heteroaryl)-C 1-6 Alkyl- and (4- to 7-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R a6 , R b6 , R c6 , and R d6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-7 Cycloalkyl, phenyl, 4- to 7-membered heterocycloalkyl-C 1-6 alkyl-, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 3-7 cycloalkyl, phenyl, and 4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R 6A are independently halo, oxo, C 1-6 Alkyl, 4-10 membered heterocycloalkyl, CN, OR a61 , C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , N.R. c61 C(O)R b61 , N.R. c61 C(O)OR a61 , N.R. c61 C(O)NR c61 R d61 , N.R. c61 S(O)2R b61, and S(O)2R b61 Selected from R 6A Each C 1-6 The alkyl and 4- to 10-membered heterocycloalkyl are optionally substituted with 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R a61 , R b61 , R c61 , and R d61 are independent, H, C 1-6 alkyl, and phenyl; R a61 , R b61 , R c61 , and R d61 C 1-6 alkyl and phenyl are each optionally substituted with one or two independently selected R 6B is substituted by a substituent, Each R 6B independently, C 1-6 Alkyl, CN, and C(O)NR c62 R d62 Selected from R 6B Each C 1-6 alkyl is optionally substituted by CN; Each R c62 and R d62 are independently H and C 1-3 alkyl.

[0310] In some embodiments, W is CH2, Y is CH2, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl; and each of cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl in Ring A is optionally substituted with one or two independently selected R 6 is substituted by a substituent, R 2 is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R 2 ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R 2A are independently selected from fluoro, methyl, CD3, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy, and methyl, cyclopropyl, pyrazolyl, and piperazinylmethyl are each optionally coupled to one or two independently selected R 2B is substituted with a substituent, Each R 2B independently, C 1-6 Alkyl and S(O)R b22 Selected from R 2B C 1-6 each alkyl is optionally substituted with CN; Each R b22 are independently H or C 1-6 alkyl, R3 is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl; R 3 phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally represented by 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A is independently selected from methyl, trideuteromethyl, ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3A methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally replaced by 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R 3B is independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano; R 4However, H and C 1-6 alkyl, R 5 However, H and C 1-6 alkyl, Each R 6 is independently selected from ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino; R 6 ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino are each optionally substituted with one or two independently selected R 6A is substituted with a substituent, Each R 6A is independently selected from fluoro, oxo, methyl, CN, methoxy, tetrahydropyranyl, methylcarbonyl, aminocarbonyl, methylcarbonylamino, ethylaminocarbonyl, methoxycarbonyl, methoxycarbonylamino, ethylaminocarbonyl, ethylsulfonyl, and phenylsulfonylamino; R6A each methyl in is optionally substituted by CN or aminocarbonyl, and R 6A is optionally substituted by cyanomethyl.

[0311] In some embodiments, W is CH2, Y is CH2, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl; and each of cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl in Ring A is optionally substituted with one or two independently selected R 6 is substituted by a substituent, R 2 is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R 2 ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R 2A are independently selected from fluoro, methyl, CD3, trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy, and methyl, cyclopropyl, pyrazolyl, and piperazinylmethyl are each optionally coupled to one or two independently selected R 2B is substituted with a substituent, Each R 2B independently, C 1-6 Alkyl and S(O)R b22 Selected from R 2B C 1-6 each alkyl is optionally substituted with CN; Each R b22 are independently H or C 1-6 alkyl, R 3 is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl; R 3 phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally represented by 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A is independently selected from methyl, trideuteromethyl, ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R 3Amethyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally replaced by 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R 3B is independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano; R 4 However, H and C 1-6 alkyl, R 5 However, H and C 1-6 alkyl, Each R 6 is independently selected from ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino; R 6ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino are each optionally substituted with one or two independently selected R 6A is substituted with a substituent, Each R 6A is independently selected from fluoro, oxo, methyl, CN, methoxy, tetrahydropyranyl, methylcarbonyl, aminocarbonyl, methylcarbonylamino, ethylaminocarbonyl, methoxycarbonyl, methoxycarbonylamino, ethylaminocarbonyl, ethylsulfonyl, and phenylsulfonylamino; R 6A each methyl in is optionally substituted by CN or aminocarbonyl, and R 6A is optionally substituted by cyanomethyl.

[0312] In some embodiments, W is C(R W )2, Y is C(R Y )2, Each R W are independently H or C 1-6 is alkyl, Each R Y are independently H or C 1-6 is alkyl, Ring A is C 3-10 cycloalkyl or 4- to 10-membered heterocycloalkyl, and C of ring A 3-10The cycloalkyl and 4- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6 is substituted with a substituent, R 2 But C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 2 C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R 2A But C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R 2A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10Cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl are each optionally joined by 1, 2, 3, or 4 independently selected R 2B is substituted with a substituent, Each R 2B are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R 2B C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 each alkynyl is optionally substituted by cyano; R 3 But C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3 C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R 3B are independent, S(O)2R b32 is selected from Each R b32 are independently H and C 1-6 alkyl, R 4 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, and C 1-6 haloalkoxy; R 5 But H, C 1-6 Alkyl, C 1-6 Alkoxy, C 1-6 Haloalkyl, C 1-6 Haloalkoxy, C 2-6 Alkenyl, and C 2-6alkynyl, Each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , and C(O)OR a6 Selected from R 6 C 1-6 Alkyl, C 2-6 Alkenyl, C 2-6 Alkynyl, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C 6-10 Aryl-C 1-6 Alkyl-, C 3-10 Cycloalkyl-C 1-6 Alkyl-, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R a6 , R b6 , R c6 , and R d6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R a6 , R b6 , R c6, and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R 6A independently, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, CN, C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , and OC(O)R c61 Selected from R 6A C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl are each optionally joined by 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R a61 , R b61 , R c61 , and R d61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl optionally has 1, 2, 3, or 4 independently selected R 6B is substituted by a substituent, Each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, C1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally substituted by CN.

[0313] In some embodiments, W is C(R W )2, Y is C(R Y )2, Each R W are independently H or C 1-6 is alkyl, Each R Y are independently H or C 1-6 is alkyl, Ring A is C 3-10 cycloalkyl or 4- to 10-membered heterocycloalkyl, and C of ring A 3-10 The cycloalkyl and 4- to 10-membered heterocycloalkyl each optionally have 1, 2, 3, or 4 independently selected R 6 is substituted with a substituent, R 2 But C 6-10 aryl and 5- to 10-membered heteroaryl; R 2 C 6-10 The aryl and the 5- to 10-membered heteroaryl each optionally have 1, 2, 3, or 4 independently selected R 2A is substituted by a substituent, Each R 2A independently, C 1-6 alkyl, and 5- to 10-membered heteroaryl; R 2A C 1-6 The alkyl and 5- to 10-membered heteroaryl are each optionally substituted with one or two independently selected R 2B is substituted with a substituent, Each R 2B However, H and C 1-6 alkyl, and R 2B C 1-6 alkyl is optionally substituted by cyano; R 3 But C6-10 Aryl, C 3-10 cycloalkyl, and 5- to 10-membered heteroaryl; R 3 C 6-10 Aryl, C 3-10 The cycloalkyl and the 5- to 10-membered heteroaryl are each optionally substituted with 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A independently, C 1-6 Alkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R 3B are independent, S(O)2R b32 is selected from Each R b32 are independently H and C 1-6 alkyl, R 4 However, H and C 1-6 alkyl, R 5 However, H and C 1-6 alkyl, Each R 6 independently, C 1-6 Alkyl, C 1-6 Haloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl-, (4-10 membered heterocycloalkyl)-C 1-6 Alkyl-, C(O)R b6 , C(O)NR c6 R d6 , and C(O)OR a6 Selected from R 6 C1-6 Alkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, (5- to 10-membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R a6 , R b6 , R c6 , and R d6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R a6 , R b6 , R c6 , and R d6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R 6A independently, C 6-10 Aryl, C 3-10 Cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, CN, C(O)R b61 , C(O)NR c61 R d61 , C(O)OR a61 , and OC(O)R c61 Selected from R 6A C 6-10 Aryl, C 3-10 Cycloalkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl are each optionally joined by 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R a61 , R b61 , R c61 , and R d61 are independent, H, C 1-6 Alkyl, C1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R a61 , R b61 , R c61 , and R d61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 6B is substituted by a substituent, Each R 6B independently, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 alkynyl, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, and C 2-6 Each alkynyl is optionally substituted by CN.

[0314] In some embodiments, W is CH2, Y is CH2, Ring A is C 3-7 C of ring A is selected from cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, and bicyclic 8- to 10-membered heterocycloalkyl; 3-7 The cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, and bicyclic 8- to 10-membered heterocycloalkyl each optionally contain 1, 2, 3, or 4 independently selected R 6 is substituted by a substituent, R 2 is selected from phenyl and indazolyl; R 2 and indazolyl are each optionally selected from 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R 2A independently, C 1-6alkyl, and 5- to 10-membered heteroaryl; R 2A C 1-6 The alkyl and 5- to 10-membered heteroaryl are each optionally substituted with one or two independently selected R 2B is substituted with a substituent, Each R 2B are independently H and C 1-6 alkyl, and R 2B C 1-6 alkyl is optionally substituted by CN; R 3 is selected from phenyl, cyclopropyl, and pyrazolyl; R 3 phenyl, cyclopropyl, and pyrazolyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A independently, C 1-6 Alkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R 3B are independent, S(O)2R b32 is selected from Each R b32 are independently H and C 1-6 alkyl, R 4 However, H and C 1-6 alkyl, R 5 However, H and C 1-6 alkyl, Each R 6 independently, C 1-6Alkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, and C(O)R b6 Selected from R 6 C 1-6 Alkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R b6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R b6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 6A is substituted by a substituent, Each R 6A are independently 4 to 10 membered heterocycloalkyl, CN, and C(O)R b61 Selected from R 6A each 4- to 10-membered heterocycloalkyl optionally being selected from 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R b61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R b61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl is optionally selected from one or two independently selected R 6B is substituted by a substituent, Each R 6B independently, C 1-6 alkyl, and R 6B C 1-6The alkyl is optionally substituted by CN.

[0315] In some embodiments, W is CH2, Y is CH2, Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl, and each of the cyclobutyl, cyclopentyl, cyclohexyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, and azabicyclo[3.2.1]octanyl of Ring A is optionally substituted with 1, 2, 3, or 4 independently selected R 6 is substituted by a substituent, R 2 is selected from phenyl and indazolyl; R 2 and indazolyl are each optionally selected from 1, 2, 3, or 4 independently selected R 2A is substituted with a substituent, Each R 2A independently, C 1-6 alkyl, and 5- to 10-membered heteroaryl; R 2A C 1-6 The alkyl and 5- to 10-membered heteroaryl are each optionally substituted with one or two independently selected R 2B is substituted with a substituent, Each R 2B are independently H and C 1-6 alkyl, and R 2B C 1-6 alkyl is optionally substituted by CN; R 3 is selected from phenyl, cyclopropyl, and pyrazolyl; R 3 phenyl, cyclopropyl, and pyrazolyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 3A is substituted with a substituent, Each R 3A independently, C1-6 Alkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 alkyl-, and R 3A C 1-6 Alkyl, (5-10 membered heteroaryl)-C 1-6 Alkyl- and (4- to 10-membered heterocycloalkyl)-C 1-6 Each alkyl- is optionally substituted with 1, 2, 3, or 4 independently selected R 3B is substituted with a substituent, Each R 3B are independent, S(O)2R b32 is selected from Each R b32 are independently H and C 1-6 alkyl, R 4 However, H and C 1-6 alkyl, R 5 However, H and C 1-6 alkyl, Each R 6 independently, C 1-6 Alkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, and C(O)R b6 Selected from R 6 C 1-6 Alkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl are each optionally substituted with 1, 2, 3, or 4 independently selected R 6A is substituted with a substituent, Each R b6 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R b6 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R 6Ais substituted by a substituent, Each R 6A are independently 4 to 10 membered heterocycloalkyl, CN, and C(O)R b61 Selected from R 6A each 4- to 10-membered heterocycloalkyl optionally being selected from 1, 2, 3, or 4 independently selected R 6B is substituted with a substituent, Each R b61 are independent, H, C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 alkynyl, and R b61 C 1-6 Alkyl, C 1-6 Haloalkyl, C 2-6 Alkenyl, C 2-6 Each alkynyl is optionally selected from one or two independently selected R 6B is substituted by a substituent, Each R 6B independently, C 1-6 alkyl, and R 6B C 1-6 The alkyl is optionally substituted by CN.

[0316] In some embodiments, the compound of formula I is a compound of formula II: [ka] or a pharmaceutically acceptable salt thereof.

[0317] In some embodiments, the compound of formula I is a compound of formula IIa: [ka] or a pharmaceutically acceptable salt thereof.

[0318] In some embodiments, the compound of Formula I is a compound of Formula IIb: [ka] or a pharmaceutically acceptable salt thereof.

[0319] In some embodiments, the compound of formula I is a compound of formula III: [ka] or a pharmaceutically acceptable salt thereof.

[0320] In some embodiments, the compound of Formula I is a compound of Formula IIIa: [ka] or a pharmaceutically acceptable salt thereof.

[0321] In some embodiments, the compound of Formula I is a compound of Formula IIIb: [ka] or a pharmaceutically acceptable salt thereof.

[0322] In some embodiments, the compound of formula I is a compound of formula IV: [ka] or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, 2, 3, 4, or 5.

[0323] In some embodiments, the compound of formula I is a compound of formula IVa: [ka] or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, 2, 3, 4, or 5.

[0324] In some embodiments, the compound of Formula I is a compound of Formula IVb: [ka] or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, 2, 3, 4, or 5.

[0325] In some embodiments, the compound of formula I is a compound of formula V: [ka] or a pharmaceutically acceptable salt thereof.

[0326] In some embodiments, the compound of formula I is a compound of formula Va: [ka] or a pharmaceutically acceptable salt thereof.

[0327] In some embodiments, the compound of Formula I is a compound of Formula Vb: [ka] or a pharmaceutically acceptable salt thereof.

[0328] In some embodiments, the compound of formula I is a compound of formula VI: [ka] or a pharmaceutically acceptable salt thereof.

[0329] In some embodiments, the compound of Formula I is a compound of Formula VIa: [ka] or a pharmaceutically acceptable salt thereof.

[0330] In some embodiments, the compound of formula I is a compound of formula VIb: [ka] or a pharmaceutically acceptable salt thereof.

[0331] In some embodiments, the compound of formula I is a compound of formula VII: [ka] or a pharmaceutically acceptable salt thereof.

[0332] In some embodiments, the compound of Formula I is a compound of Formula VIIa: [ka] or a pharmaceutically acceptable salt thereof.

[0333] In some embodiments, the compound of Formula I is a compound of Formula VIIb: [ka] or a pharmaceutically acceptable salt thereof.

[0334] In some embodiments, the compound of formula I is a compound of formula VIII: [ka] or a pharmaceutically acceptable salt thereof.

[0335] In some embodiments, the compound of Formula I is a compound of Formula VIIIa: [ka] or a pharmaceutically acceptable salt thereof.

[0336] In some embodiments, the compound of Formula I is a compound of Formula VIIIb: [ka] or a pharmaceutically acceptable salt thereof.

[0337] In some embodiments, the compound of formula I is a compound of formula IX: [ka] or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, or 2.

[0338] In some embodiments, the compound of formula I is a compound of formula IXa: [ka] or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, or 2.

[0339] In some embodiments, the compound of formula I is a compound of formula IXb: [ka] or a pharmaceutically acceptable salt thereof, wherein n is 0, 1, or 2.

[0340] In some embodiments, the compound of formula I is a compound of formula X: [ka] or a pharmaceutically acceptable salt thereof.

[0341] In some embodiments, the compound of formula I is a compound of formula Xa: [ka] or a pharmaceutically acceptable salt thereof.

[0342] In some embodiments, the compound of formula I is a compound of formula Xb: [ka] or a pharmaceutically acceptable salt thereof.

[0343] In some embodiments, a compound provided herein (e.g., a compound of any of Formulas I-Xb) or a pharmaceutically acceptable salt thereof comprises at least one deuterium atom.

[0344] In some embodiments, a compound provided herein (e.g., a compound of any of Formulas I-Xb) or a pharmaceutically acceptable salt thereof contains two or more deuterium atoms.

[0345] In some embodiments, all of the hydrogen atoms in a compound provided herein (e.g., a compound of any of Formulas I-Xb) or a pharmaceutically acceptable salt thereof are replaced with deuterium atoms.

[0346] In some embodiments, the compounds provided herein are 6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-2',3,3',5',6,6'-hexahydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridin-8,4'-pyran]-7-one; 6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-3,4',5',6-tetrahydro-2'H,7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridin-8,3'-furan]-7-one; 1-(1-acetylpiperidin-4-yl)-6'-methyl-2'-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1'-phenyl-3',6'-dihydro-7'H-spiro[azetidine-3,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 3-(6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)propanenitrile; 3-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)propanenitrile; 2-(4-(4-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)-1H-pyrazol-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile; 3-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-(methyl-d3)-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)propanenitrile; 6'-Methyl-1'-(1-methyl-1H-indazol-5-yl)-2'-(1-(pyridin-4-ylmethyl)-1H-pyrazol-4-yl)-3',6'-dihydro-7'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 2'-Cyclopropyl-6'-methyl-1'-(1-methyl-1H-indazol-5-yl)-3',6'-dihydro-7'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 6'-methyl-2'-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1'-phenyl-3',6'-dihydro-7'H-spiro[cyclobutane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 6'-methyl-2'-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1'-phenyl-3',6'-dihydro-7'H-spiro[cyclohexane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-1'-(2-(tetrahydro-2H-pyran-4-yl)acetyl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidin]-7-one; 8-acetyl-6'-methyl-2'-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1'-phenyl-3',6'-dihydro-7'H-8-azaspiro[bicyclo[3.2.1]octane-3,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 3-(4-(4-(6'-methyl-2'-(1-methyl-1H-pyrazol-4-yl)-7'-oxo-6',7'-dihydro-3'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-1'-yl)phenyl)-1H-pyrazol-1-yl)butanenitrile; 6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-1'-(pyrimidin-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyrid...

Claims

1. A compound of formula I, 【Chemistry 1】 or a pharma- ceutically acceptable salt thereof, W is CR Ｗ , C(R Ｗ ) ２ , N.R. Ｗ , O, or S; Y is CR Ｙ , C(R Ｙ ) ２ , N.R. Ｙ , O, or S; At least one of W is CR Ｗ Or C(R Ｗ ) ２ or Y is CR Ｙ Or C(R Ｙ ) ２ and Each R Ｗ are independently H, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, and C ２－６ alkynyl, Each R Ｙ are independently H, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, and C ２－６ alkynyl, Ring A is C ３－１０ cycloalkyl or 4- to 10-membered heterocycloalkyl, ３－１０ Cycloalkyl and 4- to 10-membered heterocycloalkyl each optionally have 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ６ is substituted with a substituent, R ２ But, H, halo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ２ , S.R. ａ２ , N.H.O.R. ａ２ , C(O)R ｂ２ , C(O)NR ｃ２ R ｄ２ , C(O)NR ｃ２ (OR ａ２ ), C(O)OR ａ２ , O.C.(O)R ｂ２ , O.C.(O)NR ｃ２ R ｄ２ , N.R. ｃ２ R ｄ２ , N.R. ｃ２ N.R. ｃ２ R ｄ２ , N.R. ｃ２ C(O)R ｂ２ , N.R. ｃ２ C(O)OR ａ２ , N.R. ｃ２ C(O)NR ｃ２ R ｄ２ , C(=NR ｅ２ ) R ｂ２ , C(=NR ｅ２ ) N.R. ｃ２ R ｄ２ , N.R. ｃ２ C (=NR ｅ２ ) N.R. ｃ２ R ｄ２ , N.R. ｃ２ C (=NR ｅ２ ) R ｂ２ , N.R. ｃ２ S(O)R ｂ２ , N.R. ｃ２ S(O)NR ｃ２ R ｄ２ , N.R. ｃ２ S (O) ２ R ｂ２ , N.R. ｃ２ S(O)(=NR ｅ２ ) R ｂ２ , N.R. ｃ２ S (O) ２ N.R. ｃ２ R ｄ２ , S(O)R ｂ２ , S(O)NR ｃ２ R ｄ２ , S(O) ２ R ｂ２ , S(O) ２ N.R. ｃ２ R ｄ２ , OS(O)(=NR ｅ２ ) R ｂ２ , and OS(O) ２ R ｂ２ is selected from R ２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ２Ａ is substituted with a substituent, Each R ａ２ , R ｃ２ , and R ｄ２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ２ , R ｃ２ , and R ｄ２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ２Ａ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ２ and R ｄ２ together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group, said 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R ２Ａ is substituted with a substituent, Each R ｂ２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ２Ａ is substituted with a substituent, Each R ｅ２ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, Each R ２Ａ But, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ２１ , S.R. ａ２１ , N.H.O.R. ａ２１ , C(O)R ｂ２１ , C(O)NR ｃ２１ R ｄ２１ , C(O)NR ｃ２１ (OR ａ２１ ), C(O)OR ａ２１ , O.C.(O)R ｂ２１ , O.C.(O)NR ｃ２１ R ｄ２１ , N.R. ｃ２１ R ｄ２１ , N.R. ｃ２１ N.R. ｃ２１ R ｄ２１ , N.R. ｃ２１ C(O)R ｂ２１ , N.R. ｃ２１ C(O)OR ａ２１ , N.R. ｃ２１ C(O)NR ｃ２１ R ｄ２１ , C(=NR ｅ２１ ) R ｂ２１ , C(=NR ｅ２１ ) N.R. ｃ２１ R ｄ２１ , N.R. ｃ２１ C (=NR ｅ２１ ) N.R. ｃ２１ R ｄ２１ , N.R. ｃ２１ C (=NR ｅ２１ ) R ｂ２１ , N.R. ｃ２１ S(O)R ｂ２１ , N.R. ｃ２１ S(O)NR ｃ２１ R ｄ２１ , N.R. ｃ２１ S (O) ２ R ｂ２１ , N.R. ｃ２１ S(O)(=NR ｅ２１ ) R ｂ２１ , N.R. ｃ２１ S (O) ２ N.R. ｃ２１ R ｄ２１ , S(O)R ｂ２１ , S(O)NR ｃ２１ R ｄ２１ , S(O) ２ R ｂ２１ , S(O) ２ N.R. ｃ２１ R ｄ２１ , OS(O)(=NR ｅ２１ ) R ｂ２１ , and OS(O) ２ R ｂ２１ is selected from R ２Ａ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ２Ｂ is substituted with a substituent, Each R ａ２１ , R ｃ２１ , and R ｄ２１ are independently H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ２１ , R ｃ２１ , and R ｄ２１ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ２Ｂ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ２１ and R ｄ２１ together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group, said 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R ２Ｂ is substituted with a substituent, Each R ｂ２１ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ２１ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ２Ｂ is substituted with a substituent, Each R ｅ２１ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, Each R ２Ｂ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ２２ , S.R. ａ２２ , N.H.O.R. ａ２２ , C(O)R ｂ２２ , C(O)NR ｃ２２ R ｄ２２ , C(O)NR ｃ２２ (OR ａ２２ ), C(O)OR ａ２２ , O.C.(O)R ｂ２２ , O.C.(O)NR ｃ２２ R ｄ２２ , N.R. ｃ２２ R ｄ２２ , N.R. ｃ２２ N.R. ｃ２２ R ｄ２２ , N.R. ｃ２２ C(O)R ｂ２２ , N.R. ｃ２２ C(O)OR ａ２２ , N.R. ｃ２２ C(O)NR ｃ２２ R ｄ２２ , C(=NR ｅ２２ ) R ｂ２２ , C(=NR ｅ２２ ) N.R. ｃ２２ R ｄ２２ , N.R. ｃ２２ C (=NR ｅ２２ ) N.R. ｃ２２ R ｄ２２ , N.R. ｃ２２ C (=NR ｅ２２ ) R ｂ２２ , N.R. ｃ２２ S(O)R ｂ２２ , N.R. ｃ２２ S(O)NR ｃ２２ R ｄ２２ , N.R. ｃ２２ S (O) ２ R ｂ２２ , N.R. ｃ２２ S(O)(=NR ｅ２２ ) R ｂ２２ , N.R. ｃ２２ S (O) ２ N.R. ｃ２２ R ｄ２２ , S(O)R ｂ２２ , S(O)NR ｃ２２ R ｄ２２ , S(O) ２ R ｂ２２ , S(O) ２ N.R. ｃ２２ R ｄ２２ , OS(O)(=NR ｅ２２ ) R ｂ２２ , and OS(O) ２ R ｂ２２ is selected from R ２Ｂ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ２Ｃ is substituted with a substituent, Each R ａ２２ , R ｃ２２ , and R ｄ２２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ２２ , R ｃ２２ , and R ｄ２２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ２Ｃ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ２２ and R ｄ２２ together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group, said 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R ２Ｃ is substituted with a substituent, Each R ｂ２２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ２２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ２Ｃ is substituted with a substituent, Each R ｅ２２ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, Each R ２Ｃ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl-, (4- to 7-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ２３ , S.R. ａ２３ , N.H.O.R. ａ２３ , C(O)R ｂ２３ , C(O)NR ｃ２３ R ｄ２３ , C(O)NR ｃ２３ (OR ａ２３ ), C(O)OR ａ２３ , O.C.(O)R ｂ２３ , O.C.(O)NR ｃ２３ R ｄ２３ , N.R. ｃ２３ R ｄ２３ , N.R. ｃ２３ N.R. ｃ２３ R ｄ２３ , N.R. ｃ２３ C(O)R ｂ２３ , N.R. ｃ２３ C(O)OR ａ２３ , N.R. ｃ２３ C(O)NR ｃ２３ R ｄ２３ , C(=NR ｅ２３ ) R ｂ２３ , C(=NR ｅ２３ ) N.R. ｃ２３ R ｄ２３ , N.R. ｃ２３ C (=NR ｅ２３ ) N.R. ｃ２３ R ｄ２３ , N.R. ｃ２３ C (=NR ｅ２３ ) R ｂ２３ , N.R. ｃ２３ S(O)R ｂ２３ , N.R. ｃ２３ S(O)NR ｃ２３ R ｄ２３ , N.R. ｃ２３ S (O) ２ R ｂ２３ , N.R. ｃ２３ S(O)(=NR ｅ２３ ) R ｂ２３ , N.R. ｃ２３ S (O) ２ N.R. ｃ２３ R ｄ２３ , S(O)R ｂ２３ , S(O)NR ｃ２３ R ｄ２３ , S(O) ２ R ｂ２３ , S(O) ２ N.R. ｃ２３ R ｄ２３ , OS(O)(=NR ｅ２３ ) R ｂ２３ , and OS(O) ２ R ｂ２３ is selected from R ２Ｃ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl-, (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R Ｍ is substituted with a substituent, Each R ａ２３ , R ｃ２３ , and R ｄ２３ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ａ２３ , R ｃ２３ , and R ｄ２３ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R Ｍ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ２３ and R ｄ２３ together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group, said 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R Ｍ is substituted with a substituent, Each R ｂ２３ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ２３ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R Ｍ is substituted with a substituent, Each R ｅ２３ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ３ But, H, halo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ３ , S.R. ａ３ , N.H.O.R. ａ３ , C(O)R ｂ３ , C(O)NR ｃ３ R ｄ３ , C(O)NR ｃ３ (OR ａ３ ), C(O)OR ａ３ , O.C.(O)R ｂ３ , O.C.(O)NR ｃ３ R ｄ３ , N.R. ｃ３ R ｄ３ , N.R. ｃ３ N.R. ｃ３ R ｄ３ , N.R. ｃ３ C(O)R ｂ３ , N.R. ｃ３ C(O)OR ａ３ , N.R. ｃ３ C(O)NR ｃ３ R ｄ３ , C(=NR ｅ３ ) R ｂ３ , C(=NR ｅ３ ) N.R. ｃ３ R ｄ３ , N.R. ｃ３ C (=NR ｅ３ ) N.R. ｃ３ R ｄ３ , N.R. ｃ３ C (=NR ｅ３ ) R ｂ３ , N.R. ｃ３ S(O)R ｂ３ , N.R. ｃ３ S(O)NR ｃ３ R ｄ３ , N.R. ｃ３ S (O) ２ R ｂ３ , N.R. ｃ３ S(O)(=NR ｅ３ ) R ｂ３ , N.R. ｃ３ S (O) ２ N.R. ｃ３ R ｄ３ , S(O)R ｂ３ , S(O)NR ｃ３ R ｄ３ , S(O) ２ R ｂ３ , S(O) ２ N.R. ｃ３ R ｄ３ , OS(O)(=NR ｅ３ ) R ｂ３ , and OS(O) ２ R ｂ３ is selected from R ３ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ３Ａ is substituted with a substituent, Each R ａ３ , R ｃ３ , and R ｄ３ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ３ , R ｃ３ , and R ｄ３ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ３Ａ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ３ and R ｄ３ together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group, said 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R ３Ａ is substituted with a substituent, Each R ｂ３ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ３ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ３Ａ is substituted with a substituent, Each R ｅ３ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, Each R ３Ａ But, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ３１ , S.R. ａ３１ , N.H.O.R. ａ３１ , C(O)R ｂ３１ , C(O)NR ｃ３１ R ｄ３１ , C(O)NR ｃ３１ (OR ａ３１ ), C(O)OR ａ３１ , O.C.(O)R ｂ３１ , O.C.(O)NR ｃ３１ R ｄ３１ , N.R. ｃ３１ R ｄ３１ , N.R. ｃ３１ N.R. ｃ３１ R ｄ３１ , N.R. ｃ３１ C(O)R ｂ３１ , N.R. ｃ３１ C(O)OR ａ３１ , N.R. ｃ３１ C(O)NR ｃ３１ R ｄ３１ , C(=NR ｅ３１ ) R ｂ３１ , C(=NR ｅ３１ ) N.R. ｃ３１ R ｄ３１ , N.R. ｃ３１ C (=NR ｅ３１ ) N.R. ｃ３１ R ｄ３１ , N.R. ｃ３１ C (=NR ｅ３１ ) R ｂ３１ , N.R. ｃ３１ S(O)R ｂ３１ , N.R. ｃ３１ S(O)NR ｃ３１ R ｄ３１ , N.R. ｃ３１ S (O) ２ R ｂ３１ , N.R. ｃ３１ S(O)(=NR ｅ３１ ) R ｂ３１ , N.R. ｃ３１ S (O) ２ N.R. ｃ３１ R ｄ３１ , S(O)R ｂ３１ , S(O)NR ｃ３１ R ｄ３１ , S(O) ２ R ｂ３１ , S(O) ２ N.R. ｃ３１ R ｄ３１ , OS(O)(=NR ｅ３１ ) R ｂ３１ , and OS(O) ２ R ｂ３１ is selected from R ３Ａ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ３Ｂ is substituted with a substituent, Each R ａ３１ , R ｃ３１ , and R ｄ３１ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ３１ , R ｃ３１ , and R ｄ３１ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ３Ｂ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ３１ and R ｄ３１ together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group, said 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R ３Ｂ is substituted with a substituent, Each R ｂ３１ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ３１ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ３Ｂ is substituted with a substituent, Each R ｅ３１ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, Each R ３Ｂ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ３２ , S.R. ａ３２ , N.H.O.R. ａ３２ , C(O)R ｂ３２ , C(O)NR ｃ３２ R ｄ３２ , C(O)NR ｃ３２ (OR ａ３２ ), C(O)OR ａ３２ , O.C.(O)R ｂ３２ , O.C.(O)NR ｃ３２ R ｄ３２ , N.R. ｃ３２ R ｄ３２ , N.R. ｃ３２ N.R. ｃ３２ R ｄ３２ , N.R. ｃ３２ C(O)R ｂ３２ , N.R. ｃ３２ C(O)OR ａ３２ , N.R. ｃ３２ C(O)NR ｃ３２ R ｄ３２ , C(=NR ｅ３２ ) R ｂ３２ , C(=NR ｅ３２ ) N.R. ｃ３２ R ｄ３２ , N.R. ｃ３２ C (=NR ｅ３２ ) N.R. ｃ３２ R ｄ３２ , N.R. ｃ３２ C (=NR ｅ３２ ) R ｂ３２ , N.R. ｃ３２ S(O)R ｂ３２ , N.R. ｃ３２ S(O)NR ｃ３２ R ｄ３２ , N.R. ｃ３２ S (O) ２ R ｂ３２ , N.R. ｃ３２ S(O)(=NR ｅ３２ ) R ｂ３２ , N.R. ｃ３２ S (O) ２ N.R. ｃ３２ R ｄ３２ , S(O)R ｂ３２ , S(O)NR ｃ３２ R ｄ３２ , S(O) ２ R ｂ３２ , S(O) ２ N.R. ｃ３２ R ｄ３２ , OS(O)(=NR ｅ３２ ) R ｂ３２ , and OS(O) ２ R ｂ３２ is selected from R ３Ｂ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ３Ｃ is substituted with a substituent, Each R ａ３２ , R ｃ３２ , and R ｄ３２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ３２ , R ｃ３２ , and R ｄ３２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ３Ｃ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ３２ and R ｄ３２ together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group, said 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R ３Ｃ is substituted with a substituent, Each R ｂ３２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ３２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ３Ｃ is substituted with a substituent, Each R ｅ３２ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, Each R ３Ｃ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl-, (4- to 7-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ３３ , S.R. ａ３３ , N.H.O.R. ａ３３ , C(O)R ｂ３３ , C(O)NR ｃ３３ R ｄ３３ , C(O)NR ｃ３３ (OR ａ３３ ), C(O)OR ａ３３ , O.C.(O)R ｂ３３ , O.C.(O)NR ｃ３３ R ｄ３３ , N.R. ｃ３３ R ｄ３３ , N.R. ｃ３３ N.R. ｃ３３ R ｄ３３ , N.R. ｃ３３ C(O)R ｂ３３ , N.R. ｃ３３ C(O)OR ａ３３ , N.R. ｃ３３ C(O)NR ｃ３３ R ｄ３３ , C(=NR ｅ３３ ) R ｂ３３ , C(=NR ｅ３３ ) N.R. ｃ３３ R ｄ３３ , N.R. ｃ３３ C (=NR ｅ３３ ) N.R. ｃ３３ R ｄ３３ , N.R. ｃ３３ C (=NR ｅ３３ ) R ｂ３３ , N.R. ｃ３３ S(O)R ｂ３３ , N.R. ｃ３３ S(O)NR ｃ３３ R ｄ３３ , N.R. ｃ３３ S (O) ２ R ｂ３３ , N.R. ｃ３３ S(O)(=NR ｅ３３ ) R ｂ３３ , N.R. ｃ３３ S (O) ２ N.R. ｃ３３ R ｄ３３ , S(O)R ｂ３３ , S(O)NR ｃ３３ R ｄ３３ , S(O) ２ R ｂ３３ , S(O) ２ N.R. ｃ３３ R ｄ３３ , OS(O)(=NR ｅ３３ ) R ｂ３３ , and OS(O) ２ R ｂ３３ is selected from R ３Ｃ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl-, (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R Ｍ is substituted with a substituent, Each R ａ３３ , R ｃ３３ , and R ｄ３３ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ａ３３ , R ｃ３３ , and R ｄ３３ C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R Ｍ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ３３ and R ｄ３３ together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group, said 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R Ｍ is substituted with a substituent, Each R ｂ３３ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ３３ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R Ｍ is substituted with a substituent, Each R ｅ３３ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ４ But, H, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, OH, NH ２ , and N.H.C. １－６ alkyl, １－６ Alkyl is optionally selected from OH, CN, and NH ２ is replaced by R ５ But, H, halo, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, OH, CN, C(O)OH, C(O)NHR ａ５ , N.H. ２ , and N.H.C. １－６ alkyl, １－６ Alkyl is optionally selected from OH, CN, and NH ２ is replaced by R ａ５ But, H, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, OH, NH ２ , and N.H.C. １－６ alkyl, １－６ Alkyl is optionally selected from OH, CN, and NH ２ is replaced by Each R ６ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ６ , S.R. ａ６ , N.H.O.R. ａ６ , C(O)R ｂ６ , C(O)NR ｃ６ R ｄ６ , C(O)NR ｃ６ (OR ａ６ ), C(O)OR ａ６ , O.C.(O)R ｂ６ , O.C.(O)NR ｃ６ R ｄ６ , N.R. ｃ６ R ｄ６ , N.R. ｃ６ N.R. ｃ６ R ｄ６ , N.R. ｃ６ C(O)R ｂ６ , N.R. ｃ６ C(O)OR ａ６ , N.R. ｃ６ C(O)NR ｃ６ R ｄ６ , C(=NR ｅ６ ) R ｂ６ , C(=NR ｅ６ ) N.R. ｃ６ R ｄ６ , N.R. ｃ６ C (=NR ｅ６ ) N.R. ｃ６ R ｄ６ , N.R. ｃ６ C (=NR ｅ６ ) R ｂ６ , N.R. ｃ６ S(O)R ｂ６ , N.R. ｃ６ S(O)NR ｃ６ R ｄ６ , N.R. ｃ６ S (O) ２ R ｂ６ , N.R. ｃ６ S(O)(=NR ｅ６ ) R ｂ６ , N.R. ｃ６ S (O) ２ N.R. ｃ６ R ｄ６ , S(O)R ｂ６ , S(O)NR ｃ６ R ｄ６ , S(O) ２ R ｂ６ , S(O) ２ N.R. ｃ６ R ｄ６ , OS(O)(=NR ｅ６ ) R ｂ６ , and OS(O) ２ R ｂ６ is selected from R ６ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ６Ａ is substituted with a substituent, Each R ａ６ , R ｃ６ , and R ｄ６ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ６ , R ｃ６ , and R ｄ６ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ６Ａ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ６ and R ｄ６ together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group, said 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R ６Ａ is substituted with a substituent, Each R ｂ６ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ６ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ６Ａ is substituted with a substituent, Each R ｅ６ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, Each R ６Ａ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ６１ , S.R. ａ６１ , N.H.O.R. ａ６１ , C(O)R ｂ６１ , C(O)NR ｃ６１ R ｄ６１ , C(O)NR ｃ６１ (OR ａ６１ ), C(O)OR ａ６１ , O.C.(O)R ｂ６１ , O.C.(O)NR ｃ６１ R ｄ６１ , N.R. ｃ６１ R ｄ６１ , N.R. ｃ６１ N.R. ｃ６１ R ｄ６１ , N.R. ｃ６１ C(O)R ｂ６１ , N.R. ｃ６１ C(O)OR ａ６１ , N.R. ｃ６１ C(O)NR ｃ６１ R ｄ６１ , C(=NR ｅ６１ ) R ｂ６１ , C(=NR ｅ６１ ) N.R. ｃ６１ R ｄ６１ , N.R. ｃ６１ C (=NR ｅ６１ ) N.R. ｃ６１ R ｄ６１ , N.R. ｃ６１ C (=NR ｅ６１ ) R ｂ６１ , N.R. ｃ６１ S(O)R ｂ６１ , N.R. ｃ６１ S(O)NR ｃ６１ R ｄ６１ , N.R. ｃ６１ S (O) ２ R ｂ６１ , N.R. ｃ６１ S(O)(=NR ｅ６１ ) R ｂ６１ , N.R. ｃ６１ S (O) ２ N.R. ｃ６１ R ｄ６１ , S(O)R ｂ６１ , S(O)NR ｃ６１ R ｄ６１ , S(O) ２ R ｂ６１ , S(O) ２ N.R. ｃ６１ R ｄ６１ , OS(O)(=NR ｅ６１ ) R ｂ６１ , and OS(O) ２ R ｂ６１ is selected from R ６Ａ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ６Ｂ is substituted with a substituent, Each R ａ６１ , R ｃ６１ , and R ｄ６１ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ６１ , R ｃ６１ , and R ｄ６１ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ６Ｂ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ６１ and R ｄ６１ together with the N atom to which they are attached form a 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group, said 5- to 10-membered heteroaryl or 4- to 10-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R ６Ｂ is substituted with a substituent, Each R ｂ６１ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ６１ C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, 4, 5, 6, 7, or 8 independently selected R ６Ｂ is substituted with a substituent, Each R ｅ６１ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, Each R ６Ｂ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl-, (4- to 7-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ６２ , S.R. ａ６２ , N.H.O.R. ａ６２ , C(O)R ｂ６２ , C(O)NR ｃ６２ R ｄ６２ , C(O)NR ｃ６２ (OR ａ６２ ), C(O)OR ａ６２ , O.C.(O)R ｂ６２ , O.C.(O)NR ｃ６２ R ｄ６２ , N.R. ｃ６２ R ｄ６２ , N.R. ｃ６２ N.R. ｃ６２ R ｄ６２ , N.R. ｃ６２ C(O)R ｂ６２ , N.R. ｃ６２ C(O)OR ａ６２ , N.R. ｃ６２ C(O)NR ｃ６２ R ｄ６２ , C(=NR ｅ６２ ) R ｂ６２ , C(=NR ｅ６２ ) N.R. ｃ６２ R ｄ６２ , N.R. ｃ６２ C (=NR ｅ６２ ) N.R. ｃ６２ R ｄ６２ , N.R. ｃ６２ C (=NR ｅ６２ ) R ｂ６２ , N.R. ｃ６２ S(O)R ｂ６２ , N.R. ｃ６２ S(O)NR ｃ６２ R ｄ６２ , N.R. ｃ６２ S (O) ２ R ｂ６２ , N.R. ｃ６２ S(O)(=NR ｅ６２ ) R ｂ６２ , N.R. ｃ６２ S (O) ２ N.R. ｃ６２ R ｄ６２ , S(O)R ｂ６２ , S(O)NR ｃ６２ R ｄ６２ , S(O) ２ R ｂ６２ , S(O) ２ N.R. ｃ６２ R ｄ６２ , OS(O)(=NR ｅ６２ ) R ｂ６２ , and OS(O) ２ R ｂ６２ is selected from R ６Ｂ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ｃ is substituted with a substituent, Each R ａ６２ , R ｃ６２ , and R ｄ６２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ａ６２ , R ｃ６２ , and R ｄ６２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ｃ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ６２ and R ｄ６２ together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group, said 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R ６Ｃ is substituted with a substituent, Each R ｂ６２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ６２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ｃ is substituted with a substituent, Each R ｅ６２ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, Each R ６Ｃ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl-, (4- to 7-membered heterocycloalkyl)-C １－６ Alkyl-, CN, NO ２ , OR ａ６３ , S.R. ａ６３ , N.H.O.R. ａ６３ , C(O)R ｂ６３ , C(O)NR ｃ６３ R ｄ６３ , C(O)NR ｃ６３ (OR ａ６３ ), C(O)OR ａ６３ , O.C.(O)R ｂ６３ , O.C.(O)NR ｃ６３ R ｄ６３ , N.R. ｃ６３ R ｄ６３ , N.R. ｃ６３ N.R. ｃ６３ R ｄ６３ , N.R. ｃ６３ C(O)R ｂ６３ , N.R. ｃ６３ C(O)OR ａ６３ , N.R. ｃ６３ C(O)NR ｃ６３ R ｄ６３ , C(=NR ｅ６３ ) R ｂ６３ , C(=NR ｅ６３ ) N.R. ｃ６３ R ｄ６３ , N.R. ｃ６３ C (=NR ｅ６３ ) N.R. ｃ６３ R ｄ６３ , N.R. ｃ６３ C (=NR ｅ６３ ) R ｂ６３ , N.R. ｃ６３ S(O)R ｂ６３ , N.R. ｃ６３ S(O)NR ｃ６３ R ｄ６３ , N.R. ｃ６３ S (O) ２ R ｂ６３ , N.R. ｃ６３ S(O)(=NR ｅ６３ ) R ｂ６３ , N.R. ｃ６３ S (O) ２ N.R. ｃ６３ R ｄ６３ , S(O)R ｂ６３ , S(O)NR ｃ６３ R ｄ６３ , S(O) ２ R ｂ６３ , S(O) ２ N.R. ｃ６３ R ｄ６３ , OS(O)(=NR ｅ６３ ) R ｂ６３ , and OS(O) ２ R ｂ６３ is selected from R ６Ｃ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R Ｍ is substituted with a substituent, Each R ａ６３ , R ｃ６３ , and R ｄ６３ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ａ６３ , R ｃ６３ , and R ｄ６３ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R Ｍ Is substituted with a substituent, Alternatively, any R bonded to the same N atom ｃ６３ and R ｄ６３ together with the N atom to which they are attached form a 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group, said 5- to 6-membered heteroaryl or 4- to 7-membered heterocycloalkyl group optionally being selected from 1, 2, 3, or 4 independently selected R Ｍ is substituted with a substituent, Each R ｂ６３ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, R ｂ６３ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R Ｍ is substituted with a substituent, Each R ｅ６３ are independently H, OH, CN, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ alkyl-, Each R Ｍ are independently H, OH, halo, oxo, CN, C(O)OH, C(O)NH ２ , C(O)NH(C １－４ alkyl), C(O)N(C １－６ Alkyl) ２ , N.H. ２ , NO ２ , S.F. ５ , C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkoxy, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ The compound of formula I, or a pharma- ceutically acceptable salt thereof, wherein the compound is selected from: alkyl-;

2. W is C(R Ｗ ) ２ 2. The compound of claim 1, wherein:

3. Each R Ｗ are independently H or C １－６ 3. The compound of claim 1 or 2, or a pharma- ceutically acceptable salt thereof, wherein: R is an alkyl group;

4. W is CH ２ 2. The compound of claim 1, wherein:

5. Y is C(R Ｙ ) ２ 5. The compound according to any one of claims 1 to 4, which is: or a pharma- ceutically acceptable salt thereof.

6. Each R Ｙ are independently H or C １－６ 6. The compound according to any one of claims 1 to 5, or a pharma- ceutically acceptable salt thereof, wherein R is an alkyl group.

7. Y is CH ２ 5. The compound according to any one of claims 1 to 4, which is: or a pharma- ceutically acceptable salt thereof.

8. W and Y are each CH ２ 2. The compound of claim 1, wherein:

9. Ring A optionally comprises 1, 2, 3, or 4 independently selected R ６ C substituted by a substituent ３－１０ 9. The compound of any one of claims 1 to 8, or a pharma- ceutically acceptable salt thereof, which is cycloalkyl.

10. Ring A optionally comprises 1, 2, 3, or 4 independently selected R ６ C substituted by a substituent ３－７ 9. The compound of any one of claims 1 to 8, or a pharma- ceutically acceptable salt thereof, which is cycloalkyl.

11. Ring A optionally comprises 1, 2, 3, or 4 independently selected R ６ Bicyclic C substituted by substituents ８－１０ Cycloalkyl or monocyclic C ３－７ 9. The compound of any one of claims 1 to 8, or a pharma- ceutically acceptable salt thereof, which is cycloalkyl.

12. Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, and dihydroindenyl, and each of said cyclobutyl, cyclopentyl, cyclohexyl, and dihydroindenyl of Ring A is optionally selected from 1, 2, 3, or 4 independently selected R ６ The compound according to any one of claims 1 to 8, or a pharma- ceutically acceptable salt thereof, which is substituted by a substituent.

13. Ring A optionally comprises 1, 2, 3, or 4 independently selected R ６ The compound according to any one of claims 1 to 8, which is a 4- to 10-membered heterocycloalkyl substituted with a substituent, or a pharma- ceutically acceptable salt thereof.

14. Ring A is a monocyclic 4- to 6-membered heterocycloalkyl, a bicyclic 8- to 10-membered heterocycloalkyl, or a spirocyclic 7- to 10-membered heterocycloalkyl, and said monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, and spirocyclic 7- to 10-membered heterocycloalkyl of Ring A are each optionally selected from 1, 2, 3, or 4 independently selected R ６ The compound according to any one of claims 1 to 8, or a pharma- ceutically acceptable salt thereof, which is substituted by a substituent.

15. Ring A is selected from tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and said tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl of Ring A are each optionally selected from 1, 2, 3, or 4 independently selected R ６ The compound according to any one of claims 1 to 8, or a pharma- ceutically acceptable salt thereof, which is substituted by a substituent.

16. Each R ６ became independent and C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ６ , C(O)NR ｃ６ R ｄ６ , C(O)OR ａ６ , N.R. ｃ６ C(O)R ｂ６ , N.R. ｃ６ S (O) ２ R ｂ６ , and S(O) ２ R ｂ６ is selected from R ６ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ The compound according to any one of claims 1 to 10 and 13 to 15, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

17. Each R ６ became independent and C １－６ Alkyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ３－１０ Cycloalkyl-C １－６ Alkyl-, C ６－１０ Aryl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ６ , C(O)NR ｃ６ R ｄ６ , C(O)OR ａ６ , N.R. ｃ６ C(O)R ｂ６ , N.R. ｃ６ S (O) ２ R ｂ６ , and S(O) ２ R ｂ６ is selected from R ６ The above C １－６ Alkyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ３－１０ Cycloalkyl-C １－６ Alkyl-, C ６－１０ Aryl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ The compound according to any one of claims 1 to 10 and 13 to 15, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

18. Each R ａ６ , R ｂ６ , R ｃ６ , and R ｄ６ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ３－１０ Cycloalkyl, C ６－１０ aryl, and 4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ６ , R ｂ６ , R ｃ６ , and R ｄ６ The above C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ３－１０ Cycloalkyl, C ６－１０ aryl, and 4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ The compound according to any one of claims 1 to 10 and 13 to 17, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

19. Each R ６ became independent and C １－６ Alkyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ３－１０ Cycloalkyl-C １－６ Alkyl-, C ６－１０ Aryl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ６ , C(O)NR ｃ６ R ｄ６ , C(O)OR ａ６ , N.R. ｃ６ C(O)R ｂ６ , N.R. ｃ６ S (O) ２ R ｂ６ , and S(O) ２ R ｂ６ is selected from R ６ The above C １－６ Alkyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ３－１０ Cycloalkyl-C １－６ Alkyl-, C ６－１０ Aryl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ is substituted with a substituent, Each R ａ６ , R ｂ６ , R ｃ６ , and R ｄ６ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ３－１０ Cycloalkyl, C ６－１０ aryl, and 4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ６ , R ｂ６ , R ｃ６ , and R ｄ６ The above C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ３－１０ Cycloalkyl, C ６－１０ aryl, and 4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ The compound according to any one of claims 1 to 10 and 13 to 15, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

20. Each R ６ is independently selected from ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino; R ６ wherein said ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino are each optionally selected from one or two R ６Ａ The compound according to any one of claims 1 to 10 and 13 to 15, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

21. Each R ６Ａ Independently, halo, oxo, C １－６ Alkyl, 4-10 membered heterocycloalkyl, CN, OR ａ６１ , C(O)R ｂ６１ , C(O)NR ｃ６１ R ｄ６１ , C(O)OR ａ６１ , N.R. ｃ６１ C(O)R ｂ６１ , N.R. ｃ６１ C(O)OR ａ６１ , N.R. ｃ６１ C(O)NR ｃ６１ R ｄ６１ , N.R. ｃ６１ S (O) ２ R ｂ６１ , and S(O) ２ R ｂ６１ is selected from R ６Ａ Each C １－６ The alkyl and 4- to 10-membered heterocycloalkyl are optionally represented by 1, 2, 3, or 4 independently selected R ６Ｂ The compound according to any one of claims 1 to 10 and 13 to 20, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

22. Each R ａ６１ , R ｂ６１ , R ｃ６１ , and R ｄ６１ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, and C ６－１０ aryl; R ａ６１ , R ｂ６１ , R ｃ６１ , and R ｄ６１ The above C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, and C ６－１０ Each aryl is optionally selected from 1, 2, 3, or 4 independently selected R ６Ｂ 22. The compound according to any one of claims 1 to 10 and 13 to 21, or a pharma- ceutically acceptable salt thereof, which is substituted by a substituent.

23. Each R ６Ａ Independently, halo, oxo, C １－６ Alkyl, 4-10 membered heterocycloalkyl, CN, OR ａ６１ , C(O)R ｂ６１ , C(O)NR ｃ６１ R ｄ６１ , C(O)OR ａ６１ , N.R. ｃ６１ C(O)R ｂ６１ , N.R. ｃ６１ C(O)OR ａ６１ , N.R. ｃ６１ C(O)NR ｃ６１ R ｄ６１ , N.R. ｃ６１ S (O) ２ R ｂ６１ , and S(O) ２ R ｂ６１ is selected from R ６Ａ Each C １－６ The alkyl and 4- to 10-membered heterocycloalkyl are optionally represented by 1, 2, 3, or 4 independently selected R ６Ｂ is substituted with a substituent, Each R ａ６１ , R ｂ６１ , R ｃ６１ , and R ｄ６１ are independent, H, C １－６ alkyl, and phenyl; R ａ６１ , R ｂ６１ , R ｃ６１ , and R ｄ６１ The above C １－６ Each of alkyl and phenyl is optionally selected from 1, 2, 3, or 4 independently selected R ６Ｂ The compound according to any one of claims 1 to 10 and 13 to 20, or a pharma- ceutically acceptable salt thereof, which is substituted by a substituent.

24. Each R ６Ｂ became independent and C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, CN, and C(O)NR ｃ６２ R ｄ６２ and C is selected from １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, and C ２－６ Each alkynyl is optionally substituted by CN; and each R ｃ６２ and R ｄ６２ are independently H or C １－６ 24. The compound according to any one of claims 1 to 10 and 13 to 23, or a pharma- ceutically acceptable salt thereof, which is alkyl.

25. Each R ６Ａ is independently selected from fluoro, oxo, methyl, CN, methoxy, tetrahydropyranyl, methylcarbonyl, aminocarbonyl, methylcarbonylamino, ethylaminocarbonyl, methoxycarbonyl, methoxycarbonylamino, ethylaminocarbonyl, ethylsulfonyl, and phenylsulfonylamino; R ６Ａ Each methyl in is optionally substituted by CN or aminocarbonyl; ６Ａ 21. The compound of any one of claims 1 to 10 and 13 to 20, wherein each tetrahydropyranyl is optionally substituted by cyanomethyl, or a pharma- ceutically acceptable salt thereof.

26. Each R ２ But, H, C １－６ Alkyl, C ２－６ Alkenyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ２Ａ 26. The compound according to any one of claims 1 to 25, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

27. R ２ But, H, C １－６ Alkyl, C ２－６ Alkenyl, C ６－１０ aryl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R ２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ６－１０ Aryl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl are each optionally represented by 1, 2, 3, or 4 independently selected R ２Ａ 26. The compound according to any one of claims 1 to 25, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

28. R ２ is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R ２ wherein said ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl are each optionally selected from 1, 2, 3, or 4 independently selected R ２Ａ 26. The compound according to any one of claims 1 to 25, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

29. Each R ２Ａ became independent, Halo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, and OR ａ２１ is selected from R ２Ａ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ２Ｂ 29. The compound according to any one of claims 1 to 28, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

30. Each R ２Ａ became independent, Halo, C １－６ Alkyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, and OR ａ２１ is selected from R ２Ａ The above C １－６ Alkyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ２Ｂ is substituted with a substituent, Each R ａ２１ are independent, H, C １－６ Alkyl, and C １－６ 29. The compound of any one of claims 1 to 28, or a pharma- ceutically acceptable salt thereof, selected from haloalkyl.

31. Each R ２Ａ are independently fluoro, methyl, CD ３ , trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy, wherein said methyl, cyclopropyl, pyrazolyl, and piperazinylmethyl are each optionally selected from one or two independently selected R ２Ｂ 29. The compound according to any one of claims 1 to 28, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

32. R ２ is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R ２ wherein the phenyl and indazolyl are each optionally selected from fluoro, methyl, CD ３ , trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy; ２Ａ is substituted with a substituent, R ２Ａ wherein said methyl and pyrazolyl are each optionally selected from cyano-C １－６ is substituted by alkyl; R ２Ａ 26. The compound of any one of claims 1 to 25, wherein said piperazinylmethyl is optionally substituted with methylsulfonyl, or a pharma- ceutically acceptable salt thereof.

33. R ３ But, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ３ The above C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ３Ａ The compound according to any one of claims 1 to 32, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

34. R ３ But phenyl, C ３－７ Cycloalkyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl, (5-6 membered heteroaryl)-C １－６ Alkyl- and (4- to 6-membered heterocycloalkyl)-C １－６ alkyl-, R ３ The phenyl, C ３－７ Cycloalkyl, monocyclic 5- to 6-membered heteroaryl, bicyclic 8- to 10-membered heteroaryl, monocyclic 4- to 6-membered heterocycloalkyl, bicyclic 8- to 10-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl, (5-6 membered heteroaryl)-C １－６ Alkyl- and (4- to 6-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ３Ａ The compound according to any one of claims 1 to 32, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

35. R ３ is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl; R ３ wherein said phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally selected from 1, 2, 3, or 4 independently selected R ３Ａ The compound according to any one of claims 1 to 32, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

36. Each R ３Ａ independently, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ３１ , C(O)NR ｃ３１ R ｄ３１ , N.R. ｃ３１ R ｄ３１ , and S(O) ２ R ｂ３１ is selected from R ３Ａ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ３Ｂ The compound according to any one of claims 1 to 35, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

37. Each R ３Ａ are independently oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ３－１０ Cycloalkyl, 4-10 membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ３１ , C(O)NR ｃ３１ R ｄ３１ , N.R. ｃ３１ R ｄ３１ , and S(O) ２ R ｂ３１ is selected from R ３Ａ The above C １－６ Alkyl, C ３－１０ Cycloalkyl, 4-10 membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ３Ｂ is substituted with a substituent, Each R ｂ３１ , R ｃ３１ , and R ｄ３１ are independent, H, C １－６ 36. The compound of any one of claims 1 to 35, or a pharma- ceutically acceptable salt thereof, which is alkyl, and 4- to 10-membered heterocycloalkyl.

38. Each R ３Ｂ are independent, CN, OR ａ３２ , C(O)R ｂ３２ , and S(O) ２ R ｂ３２ Each R ａ３２ and R ｂ３２ are independently H and C １－６ 38. The compound of any one of claims 1 to 37, or a pharma- ceutically acceptable salt thereof, wherein: R is selected from the group consisting of alkyl, aryl, arylsulfates, arylalkyl, arylsulfates ...

39. Each R ３Ａ are independently methyl, CD ３ , ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R ３Ａ wherein the methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl each represent one, two, three, or four independently selected R ３Ｂ The compound according to any one of claims 1 to 35, or a pharma- ceutically acceptable salt thereof, which is substituted with a substituent.

40. R ３ is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl; R ３ wherein said phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally selected from 1, 2, 3, or 4 independently selected R ３Ａ is substituted with a substituent, Each R ３Ａ are independently methyl, -CD ３ , ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R ３Ａ 33. The compound of any one of claims 1 to 32, wherein said methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally substituted with one or two substituents independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano, or a pharma- ceutically acceptable salt thereof.

41. R ４ But, H, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl and C １－６ 41. The compound of any one of claims 1 to 40, or a pharma- ceutically acceptable salt thereof, selected from haloalkoxy.

42. R ４ But H and C １－６ 41. The compound of any one of claims 1 to 40, or a pharma- ceutically acceptable salt thereof, wherein: R is selected from the group consisting of alkyl, aryl, arylsulfates, arylalkyl, arylsulfates ...

43. R ４ Methyl or CD ３ 41. The compound according to any one of claims 1 to 40, which is: or a pharma- ceutically acceptable salt thereof.

44. R ５ But, H, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, and C ２－６ 44. The compound of any one of claims 1 to 43, or a pharma- ceutically acceptable salt thereof, selected from alkynyl.

45. R ５ But H and C １－６ 44. The compound of any one of claims 1 to 43, or a pharma- ceutically acceptable salt thereof, wherein: R is selected from the group consisting of alkyl, aryl, arylsulfates, arylalkyl, arylsulfates ...

46. R ５ The compound according to any one of claims 1 to 43, wherein is H, or a pharma- ceutically acceptable salt thereof.

47. R ４ But, C １－６ alkyl, R ５ The compound according to any one of claims 1 to 40, wherein is H, or a pharma- ceutically acceptable salt thereof.

48. R ４ Methyl or CD ３ and R ５ The compound according to any one of claims 1 to 40, wherein is H, or a pharma- ceutically acceptable salt thereof.

49. W is C(R Ｗ ) ２ and Y is C(R Ｙ ) ２ and Each R Ｗ are independently H or C １－６ is alkyl, Each R Ｙ are independently H or C １－６ is alkyl, Ring A is C ３－１０ cycloalkyl or 4- to 10-membered heterocycloalkyl, ３－１０ Each of the cycloalkyl and 4- to 10-membered heterocycloalkyl optionally has 1, 2, 3, or 4 independently selected R ６ is substituted with a substituent, R ２ But, H, C １－６ Alkyl, C ２－６ Alkenyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ２ The above C １－６ Alkyl, C ２－６ Alkenyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ２Ａ is substituted with a substituent, Each R ２Ａ became independent, Halo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, CN, and OR ａ２１ is selected from R ２Ａ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ２Ｂ is substituted with a substituent, Each R ａ２１ are independent, H, C １－６ Alkyl, and C １－６ haloalkyl; Each R ２Ｂ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, S(O)R ｂ２２ , and S(O) ２ R ｂ２２ is selected from R ２Ｂ The above C １－６ Alkyl, C ２－６ Alkenyl, and C ２－６ Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R ２Ｃ is substituted with a substituent, Each R ｂ２２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, and C ２－６ alkynyl, Each R ２Ｃ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, CN, and NO ２ is selected from R ３ But, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ３ The above C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ３Ａ is substituted with a substituent, Each R ３Ａ are independently oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ３１ , C(O)NR ｃ３１ R ｄ３１ , N.R. ｃ３１ R ｄ３１ , and S(O) ２ R ｂ３１ is selected from R ３Ａ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ３Ｂ is substituted with a substituent, Each R ａ３１ , R ｂ３１ , R ｃ３１ , and R ｄ３１ are independent, H, C １－６ alkyl, and 4- to 10-membered heterocycloalkyl; Each R ３Ｂ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, CN, OR ａ３２ , C(O)R ｂ３２ , C(O)NR ｃ３２ R ｄ３２ , S(O)R ｂ３２ , S(O)NR ｃ３２ R ｄ３２ , S(O) ２ R ｂ３２ , S(O) ２ N.R. ｃ３２ R ｄ３２ is selected from Each R ａ３２ , R ｂ３２ , R ｃ３２ , and R ｄ３２ are independently H and C １－６ alkyl, R ４ But, H, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl and C １－６ haloalkoxy; R ５ But, H, C １－６ Alkyl, C １－６ Alkoxy, C １－６ Haloalkyl, C １－６ Haloalkoxy, C ２－６ Alkenyl, and C ２－６ alkynyl, Each R ６ became independent and C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl-, (4- to 10-membered heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ６ , C(O)NR ｃ６ R ｄ６ , C(O)OR ａ６ , N.R. ｃ６ C(O)R ｂ６ , N.R. ｃ６ S (O) ２ R ｂ６ , and S(O) ２ R ｂ６ is selected from R ６ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ６－１０ Aryl, C ３－１０ Cycloalkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, C ６－１０ Aryl-C １－６ Alkyl-, C ３－１０ Cycloalkyl-C １－６ Alkyl-, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ is substituted with a substituent, Each R ａ６ , R ｂ６ , R ｃ６ , and R ｄ６ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ３－１０ Cycloalkyl, C ６－１０ aryl, and 4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ａ６ , R ｂ６ , R ｃ６ , and R ｄ６ The above C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ３－１０ Cycloalkyl, C ６－１０ aryl, and 4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ is substituted with a substituent, Each R ６Ａ Independently, halo, oxo, C １－６ Alkyl, 4-10 membered heterocycloalkyl, CN, OR ａ６１ , C(O)R ｂ６１ , C(O)NR ｃ６１ R ｄ６１ , C(O)OR ａ６１ , N.R. ｃ６１ C(O)R ｂ６１ , N.R. ｃ６１ C(O)OR ａ６１ , N.R. ｃ６１ C(O)NR ｃ６１ R ｄ６１ , N.R. ｃ６１ S (O) ２ R ｂ６１ , and S(O) ２ R ｂ６１ is selected from R ６Ａ Each C １－６ The alkyl and 4- to 10-membered heterocycloalkyl are optionally represented by 1, 2, 3, or 4 independently selected R ６Ｂ is substituted with a substituent, Each R ａ６１ , R ｂ６１ , R ｃ６１ , and R ｄ６１ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, and C ６－１０ aryl; R ａ６１ , R ｂ６１ , R ｃ６１ , and R ｄ６１ The above C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, and C ６－１０ Each aryl is optionally selected from 1, 2, 3, or 4 independently selected R ６Ｂ is substituted by a substituent; Each R ６Ｂ became independent and C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, CN, and C(O)NR ｃ６２ R ｄ６２ is selected from R ６Ｂ The above C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, and C ２－６ Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R ６Ｃ is substituted by a substituent; Each R ｃ６２ and R ｄ６２ are independently H or C １－６ is alkyl, Each R ６Ｃ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, CN, and NO ２ 2. The compound of claim 1, selected from:

50. W is C(R Ｗ ) ２ and Y is C(R Ｙ ) ２ and Each R Ｗ are independently H or C １－６ is alkyl, Each R Ｙ are independently H or C １－６ is alkyl, Ring A is C ３－１０ cycloalkyl or 4- to 10-membered heterocycloalkyl, ３－１０ Each of the cycloalkyl and 4- to 10-membered heterocycloalkyl optionally has 1, 2, 3, or 4 independently selected R ６ is substituted with a substituent, R ２ But, H, C １－６ Alkyl, C ２－６ Alkenyl, C ６－１０ aryl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl; R ２ The above C １－６ Alkynyl, C ２－６ Alkenyl, C ６－１０ Aryl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl are each optionally represented by 1, 2, 3, or 4 independently selected R ２Ａ is substituted with a substituent, Each R ２Ａ became independent, Halo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, (4- to 6-membered heterocycloalkyl)-C １－６ Alkyl-, CN, and OR ａ２１ is selected from R ２Ａ The above C １－６ Alkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－６ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 6-membered heterocycloalkyl, and (4- to 6-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ２Ｂ is substituted with a substituent, Each R ａ２１ are independent, H, C １－６ Alkyl, and C １－６ haloalkyl; Each R ２Ｂ Independently, halo, oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, and S(O) ２ R ｂ２２ is selected from R ２Ｂ The above C １－６ Alkyl, C ２－６ Alkenyl, and C ２－６ Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R ２Ｃ is substituted with a substituent, Each R ｂ２２ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, and C ２－６ alkynyl, Each R ２Ｃ became independent, Halo, C １－６ Alkyl, C １－６ Haloalkyl, CN, and NO ２ is selected from R ３ But phenyl, C ３－７ cycloalkyl, monocyclic 5-6 membered heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl; R ３ The phenyl, C ３－７ Cycloalkyl, monocyclic 5-6 heteroaryl, bicyclic 8-10 membered heteroaryl, and bicyclic 8-10 membered heterocycloalkyl each optionally represent 1, 2, 3, or 4 independently selected R ３Ａ is substituted with a substituent, Each R ３Ａ are independently oxo, C １－６ Alkyl, C １－６ Haloalkyl, C ３－７ Cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－６ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl-, (4- to 6-membered heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ３１ , C(O)NR ｃ３１ R ｄ３１ , N.R. ｃ３１ R ｄ３１ , and S(O) ２ R ｂ３１ is selected from R ３Ａ The above C １－６ Alkyl, C ３－７ Cycloalkyl, 4- to 6-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－６ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 6-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ３Ｂ is substituted with a substituent, Each R ｂ３１ , R ｃ３１ , and R ｄ３１ are independent, H, C １－６ alkyl, and 4- to 10-membered heterocycloalkyl; Each R ３Ｂ are independent, CN, OR ａ３２ , C(O)R ｂ３２ , S(O)R ｂ３２ , S(O)NR ｃ３２ R ｄ３２ , S(O) ２ R ｂ３２ , and S(O) ２ N.R. ｃ３２ R ｄ３２ is selected from Each R ａ３２ , R ｂ３２ , R ｃ３２ , and R ｄ３２ are independently H and C １－６ alkyl, R ４ But H and C １－６ alkyl, R ５ But H and C １－６ alkyl, Each R ６ became independent and C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl-, (4- to 7-membered heterocycloalkyl)-C １－６ Alkyl-, C(O)R ｂ６ , C(O)NR ｃ６ R ｄ６ , C(O)OR ａ６ , N.R. ｃ６ C(O)R ｂ６ , N.R. ｃ６ S (O) ２ R ｂ６ , and S(O) ２ R ｂ６ is selected from R ６ The above C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, phenyl, C ３－７ Cycloalkyl, 5- to 6-membered heteroaryl, 4- to 7-membered heterocycloalkyl, phenyl-C １－６ Alkyl-, C ３－７ Cycloalkyl-C １－６ Alkyl-, (5- to 6-membered heteroaryl)-C １－６ Alkyl- and (4- to 7-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ is substituted with a substituent, Each R ａ６ , R ｂ６ , R ｃ６ , and R ｄ６ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ３－７ Cycloalkyl, phenyl, 4- to 7-membered heterocycloalkyl-C １－６ alkyl-, R ａ６ , R ｂ６ , R ｃ６ , and R ｄ６ The above C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Alkynyl, C ３－７ cycloalkyl, phenyl, and 4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ is substituted with a substituent, Each R ６Ａ Independently, halo, oxo, C １－６ Alkyl, 4-10 membered heterocycloalkyl, CN, OR ａ６１ , C(O)R ｂ６１ , C(O)NR ｃ６１ R ｄ６１ , C(O)OR ａ６１ , N.R. ｃ６１ C(O)R ｂ６１ , N.R. ｃ６１ C(O)OR ａ６１ , N.R. ｃ６１ C(O)NR ｃ６１ R ｄ６１ , N.R. ｃ６１ S (O) ２ R ｂ６１ , and S(O) ２ R ｂ６１ is selected from R ６Ａ Each C １－６ The alkyl and 4- to 10-membered heterocycloalkyl are optionally represented by 1, 2, 3, or 4 independently selected R ６Ｂ is substituted with a substituent, Each R ａ６１ , R ｂ６１ , R ｃ６１ , and R ｄ６１ are independent, H, C １－６ alkyl, and phenyl; R ａ６１ , R ｂ６１ , R ｃ６１ , and R ｄ６１ The above C １－６ Each of alkyl and phenyl is optionally represented by one or two independently selected R ６Ｂ is substituted by a substituent; Each R ６Ｂ became independent and C １－６ Alkyl, CN, and C(O)NR ｃ６２ R ｄ６２ is selected from R ６Ｂ Each C １－６ alkyl is optionally substituted by CN; Each R ｃ６２ and R ｄ６２ are independently H and C １－３ 2. The compound of claim 1, or a pharma- ceutically acceptable salt thereof, wherein: R is selected from the group consisting of aryl, ... and aryl;

51. W is CH ２ and Y is CH ２ and Ring A is C ３－７ cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, and bicyclic 8- to 10-membered heterocycloalkyl; ３－７ Cycloalkyl, monocyclic 4- to 6-membered heterocycloalkyl, and bicyclic 8- to 10-membered heterocycloalkyl each optionally have 1, 2, 3, or 4 independently selected R ６ is substituted by a substituent; R ２ is selected from phenyl and indazolyl; R ２ wherein said phenyl and indazolyl each have one, two, three, or four independently selected R ２Ａ is substituted with a substituent, Each R ２Ａ became independent and C １－６ alkyl, and 5- to 10-membered heteroaryl; R ２Ａ The above C １－６ Each of the alkyl and 5- to 10-membered heteroaryl is optionally represented by one or two independently selected R ２Ｂ is substituted with a substituent, Each R ２Ｂ are independently H and C １－６ alkyl; R ２Ｂ The above C １－６ alkyl is optionally substituted by CN; R ３ is selected from phenyl, cyclopropyl, and pyrazolyl; R ３ wherein each of said phenyl, cyclopropyl, and pyrazolyl is optionally selected from 1, 2, 3, or 4 independently selected R ３Ａ is substituted with a substituent, Each R ３Ａ became independent and C １－６ Alkyl, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ alkyl-, R ３Ａ The above C １－６ Alkyl, (5- to 10-membered heteroaryl)-C １－６ Alkyl- and (4- to 10-membered heterocycloalkyl)-C １－６ Each alkyl- is optionally selected from 1, 2, 3, or 4 independently selected R ３Ｂ is substituted with a substituent, Each R ３Ｂ is independent, S(O) ２ R ｂ３２ is selected from Each R ｂ３２ are independently H and C １－６ alkyl, R ４ But H and C １－６ alkyl, R ５ But H and C １－６ alkyl, Each R ６ became independent and C １－６ Alkyl, 5- to 10-membered heteroaryl, 4- to 10-membered heterocycloalkyl, and C(O)R ｂ６ is selected from R ６ The above C １－６ Each of alkyl, 5- to 10-membered heteroaryl, and 4- to 10-membered heterocycloalkyl is optionally represented by 1, 2, 3, or 4 independently selected R ６Ａ is substituted with a substituent, Each R ｂ６ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ alkynyl; R ｂ６ C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Each alkynyl is optionally selected from 1, 2, 3, or 4 independently selected R ６Ａ is substituted by a substituent; Each R ６Ａ are independently 4 to 10 membered heterocycloalkyl, CN, and C(O)R ｂ６１ is selected from R ６Ａ each of said 4-10 membered heterocycloalkyl optionally has 1, 2, 3, or 4 independently selected R ６Ｂ is substituted with a substituent, Each R ｂ６１ are independent, H, C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ alkynyl; R ｂ６１ The above C １－６ Alkyl, C １－６ Haloalkyl, C ２－６ Alkenyl, C ２－６ Each alkynyl is optionally selected from one or two independently selected R ６Ｂ is substituted by a substituent; Each R ６Ｂ became independent and C １－６ alkyl; R ６Ｂ The above C １－６ 2. The compound of claim 1, or a pharma- ceutically acceptable salt thereof, wherein alkyl is optionally substituted by CN.

52. W is CH ２ and Y is CH ２ and Ring A is selected from cyclobutyl, cyclopentyl, cyclohexyl, dihydroindenyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl, and each of said cyclobutyl, cyclopentyl, tetrahydro-2H-pyranyl, tetrahydrofuranyl, azetidinyl, piperidinyl, pyrrolidinyl, azepanyl, dihydropyridinyl, azabicyclo[3.2.1]octanyl, 2-azaspiro[3.3]heptanyl, and 7-azaspiro[3.5]nonanyl of Ring A is optionally selected from one or two independently selected R ６ is substituted by a substituent; R ２ is selected from H, ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl; R ２ wherein said ethyl, ethenyl, phenyl, indazolyl, thiazolyl, thieno[3,2-c]pyridinyl, 3,6-dihydro-2H-pyranyl, and indolyl are each optionally selected from 1, 2, 3, or 4 independently selected R ２Ａ is substituted with a substituent, Each R ２Ａ are independently fluoro, methyl, CD ３ , trifluoromethyl, cyclopropyl, pyrazolyl, piperazinylmethyl, cyano, methoxy, and trifluoromethoxy, wherein said methyl, cyclopropyl, pyrazolyl, and piperazinylmethyl are each optionally selected from one or two independently selected R ２Ｂ is substituted with a substituent, Each R ２Ｂ became independent and C １－６ Alkyl and S(O) ２ R ｂ２２ is selected from R ２Ｂ The above C １－６ each alkyl is optionally substituted with CN; Each R ｂ２２ are independently H or C １－６ alkyl, R ３ is selected from phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl; R ３ wherein said phenyl, cyclopropyl, cyclohexenyl, pyrazolyl, pyrrolyl, 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridinyl, 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazinyl, 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazolyl, and pyrazolo[1,5-a]pyrimidinyl are each optionally selected from 1, 2, 3, or 4 independently selected R ３Ａ is substituted with a substituent, Each R ３Ａ is independently selected from methyl, trideuteromethyl, ethyl, isopropyl, isobutyl, difluoroethyl, trifluoroethyl, methoxy, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, morpholinylethyl, morpholinylcarbonyl, dimethylaminocarbonyl, and ethylsulfonyl; R ３Ａ wherein the methyl, ethyl, isopropyl, isobutyl, cyclopropyl, cyclopentyl, piperidinyl, tetrahydrofuranyl, tetrahydropyranyl, cyclopropylmethyl, cyclopropylethyl, phenylmethyl, pyridylmethyl, piperidinylmethyl, morpholinylmethyl, and morpholinylethyl are each optionally selected from 1, 2, 3, or 4 independently selected R ３Ｂ is substituted with a substituent, Each R ３Ｂ is independently selected from hydroxy, methoxy, methylsulfonyl, methylcarbonyl, and cyano; R ４ But H and C １－６ alkyl, R ５ But H and C １－６ alkyl, Each R ６ is independently selected from ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino; R ６ wherein said ethyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, azetidinyl, tetrahydrothiophenyl, pyrazolyl, piperidinyl, pyrimidinyl, cyclopropylmethyl, spiro[3.3]heptanylmethyl, phenylmethyl, triazolylisopropyl, azetidinylisopropyl, 2-azabicyclo[2.1.1]hexanyl, bicyclo[1.1.1]pentanyl, methylcarbonyl, tetrahydropyranylmethylcarbonyl, propylcarbonyl, dimethylaminocarbonyl, methoxycarbonyl, phenylaminocarbonyl, ethylsulfonyl, cyclobutylcarbonylamino, cyclopropylsulfonyl, and cyclopropylsulfonylamino are each optionally selected from one or two R ６Ａ is substituted with a substituent, Each R ６Ａ is independently selected from fluoro, oxo, methyl, CN, methoxy, tetrahydropyranyl, methylcarbonyl, aminocarbonyl, methylcarbonylamino, ethylaminocarbonyl, methoxycarbonyl, methoxycarbonylamino, ethylaminocarbonyl, ethylsulfonyl, and phenylsulfonylamino; R ６Ａ Each methyl in is optionally substituted by CN or aminocarbonyl; ６Ａ 2. The compound of claim 1, wherein each tetrahydropyranyl is optionally substituted by cyanomethyl, or a pharma- ceutically acceptable salt thereof.

53. The compound of formula I is a compound of formula II: 【Chemistry 2】 2. The compound of claim 1, wherein:

54. said compound of formula I being a compound of formula III: 【Chemistry 3】 2. The compound of claim 1, wherein:

55. The compound of formula I is a compound of formula IV: 【Chemistry 4】 2. The compound of claim 1, wherein n is 0, 1, 2, 3, 4, or 5, or a pharma- ceutically acceptable salt thereof.

56. 56. The compound of any one of claims 1 to 55, or a pharma- ceutically acceptable salt thereof, wherein said compound comprises at least one deuterium atom.

57. 57. The compound of any one of claims 1 to 56, or a pharma- ceutically acceptable salt thereof, wherein the compound comprises two or more deuterium atoms.

58. 58. The compound of any one of claims 1 to 57, or a pharma- ceutically acceptable salt thereof, wherein all of said hydrogen atoms in said compound are replaced by deuterium atoms.

59. 6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-2',3,3',5',6,6'-hexahydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-pyran]-7-one; 6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-3,4',5',6-tetrahydro-2'H,7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridin-8,3'-furan]-7-one; 1-(1-acetylpiperidin-4-yl)-6'-methyl-2'-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1'-phenyl-3',6'-dihydro-7'H-spiro[azetidine-3,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 3-(6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)propanenitrile; 3-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)propanenitrile; 2-(4-(4-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)-1H-pyrazol-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile; 3-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-(methyl-d3)-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)propanenitrile; 6'-methyl-1'-(1-methyl-1H-indazol-5-yl)-2'-(1-(pyridin-4-ylmethyl)-1H-pyrazol-4-yl)-3',6'-dihydro-7'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 2'-cyclopropyl-6'-methyl-1'-(1-methyl-1H-indazol-5-yl)-3',6'-dihydro-7'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 6'-methyl-2'-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1'-phenyl-3',6'-dihydro-7'H-spiro[cyclobutane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 6'-methyl-2'-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1'-phenyl-3',6'-dihydro-7'H-spiro[cyclohexane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-1'-(2-(tetrahydro-2H-pyran-4-yl)acetyl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidin]-7-one; 8-acetyl-6'-methyl-2'-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1'-phenyl-3',6'-dihydro-7'H-8-azaspiro[bicyclo[3.2.1]octane-3,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; and 3-(4-(4-(6'-methyl-2'-(1-methyl-1H-pyrazol-4-yl)-7'-oxo-6',7'-dihydro-3'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridine]-1'-yl)phenyl)-1H-pyrazol-1-yl)butanenitrile; 2. The compound of claim 1, selected from:

60. 6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1-phenyl-1'-(pyrimidin-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidin]-7-one; (1R,3r,5S)-6'-methyl-2'-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1'-phenyl-8-(pyrimidin-4-yl)-3',6'-dihydro-7'H-8-azaspiro[bicyclo[3.2.1]octane-3,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-(2-methylthiazol-5-yl)-1'-(pyrimidin-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidin]-7-one; 6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1'-(pyrimidin-4-yl)-1-vinyl-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidin]-7-one; 1-ethyl-6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1'-(pyrimidin-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidin]-7-one; 1-(3,6-dihydro-2H-pyran-4-yl)-6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1'-(pyrimidin-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidin]-7-one; N-(3-methoxyphenyl)-6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-carboxamide; 6'-methyl-2'-(1-methyl-1H-pyrazol-4-yl)-1'-(4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenyl)-3',6'-dihydro-7'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 2-(1-(ethylsulfonyl)-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)azetidin-3-yl)acetonitrile; 2-(1-acetyl-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)azetidin-3-yl)acetonitrile; 3-(cyanomethyl)-N-ethyl-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)azetidine-1-carboxamide; 2-(4-fluorophenyl)-2-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)acetamide; Methyl (3-(cyanomethyl)-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)carbamate; 1-(3-(cyanomethyl)-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)-3-ethylurea; N-(3-(cyanomethyl)-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-1-phenyl-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)benzenesulfonamide; 2-(1-(2-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-2-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(4-(morpholine-4-carbonyl)cyclohex-1-en-1-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(4-(ethylsulfonyl)phenyl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(1-(1-hydroxy-2-methylpropan-2-yl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(3-cyclopropyl-1-methyl-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(1-(1-acetylpiperidin-4-yl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrrol-3-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-2-(4,5,6,7-tetrahydropyrazolo[1,5-a])pyridin-3-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(1-(2-methoxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-2-(1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)-6-methyl-1-(1-methyl-d ３ )-1H-indol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(1-(3,5-difluoro-4-methoxyphenyl)-2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-1-(thieno[3,2-c]pyridin-2-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(1-(4-cyclopropylphenyl)-2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 2-(1-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-1-(4-(trifluoromethoxy)phenyl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 4-(1'-(1-(cyanomethyl)cyclobutyl)-2-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1-yl)benzonitrile; 2-(1-(2-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-6-methyl-7-oxo-1-(4-(trifluoromethyl)phenyl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; (R)-1-(ethylsulfonyl)-2'-(1-isopropyl-1H-pyrazol-4-yl)-6'-methyl-1'-(1-methyl-1H-indazol-5-yl)-3',6'-dihydro-7'H-spiro[azepane-4,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; (S)-1-(ethylsulfonyl)-2'-(1-isopropyl-1H-pyrazol-4-yl)-6'-methyl-1'-(1-methyl-1H-indazol-5-yl)-3',6'-dihydro-7'H-spiro[azepane-4,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; 1-(ethylsulfonyl)-2"-(1-isopropyl-1H-pyrazol-4-yl)-6"-methyl-1"-(1-methyl-1H-indazol-5-yl)-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; N-((1S,3R)-6'-methyl-1'-(1-methyl-1H-indazol-5-yl)-2'-(1-methyl-1H-pyrazol-4-yl))-7'-oxo-6',7'-dihydro-3'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-3-yl)cyclopropanesulfonamide; N-((1R,3S)-6'-methyl-1'-(1-methyl-1H-indazol-5-yl)-2'-(1-methyl-1H-pyrazol-4-yl))-7'-oxo-6',7'-dihydro-3'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-3-yl)cyclopropanesulfonamide; N-((1S,3S)-6'-methyl-1'-(1-(methyl-d ３ )-1H-indazol-5-yl)-2'-(1-methyl-1H-pyrazol-4-yl)-7'-oxo-6',7'-dihydro-3'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-3-yl)cyclopropanesulfonamide; N-((1R,3R)-6'-methyl-1'-(1-(methyl-d ３ )-1H-indazol-5-yl)-2'-(1-methyl-1H-pyrazol-4-yl)-7'-oxo-6',7'-dihydro-3'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-3-yl)cyclopropanesulfonamide; 6-methyl-2-(4-((4-(methylsulfonyl)piperidin-1-yl)methyl)phenyl)-1',3,3',6-tetrahydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridin-8,2'-inden]-7-one; Methyl 6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-(1-(methyl-d ３ )-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-dispiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,1'-cyclobutane-3',4"-piperidine]-1"-carboxylate; 1"-butyryl-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,1'-cyclobutane-3',4"-piperidin]-7-one; N,N,6-trimethyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-dispiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,1'-cyclobutane-3',4"-piperidine]-1"-carboxamide; Methyl 6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-(methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-dispiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,1'-cyclobutane-3',4"-piperidine]-1"-carboxylate; 1"-((2-methoxyethyl)sulfonyl)-6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-phenyl-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,1'-cyclobutane-3',4"-piperidin]-7-one; 4-(1″-butyryl-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-dispiro[dipyrrolo[2,3]-b:3′,2′-d]pyridine-8,1′-cyclobutane-3′,4″-piperidin]-2-yl)-N,N-dimethylcyclohex-3-ene-1-carboxamide; 1"-butyryl-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrrol-3-yl)-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,1'-cyclobutane-3',4"-piperidin]-7-one; (R)-2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidine]-1'-yl)methyl)cyclopropyl)acetonitrile; (S)-2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidine]-1'-yl)methyl)cyclopropyl)acetonitrile; 2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidine]-1'-yl)methyl)cyclopropyl)acetonitrile; 2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-2-(pyrazolo[1,5-a]pyrimidin-3-yl)-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidine]-1'-yl)methyl)cyclopropyl)acetonitrile; 4-((4-(1'-((1-(cyanomethyl)cyclopropyl)methyl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidine]-2-yl)-1H-pyrazol-1-yl)methyl)benzonitrile; 2-(2-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidine]-1'-yl)methyl)spiro[3.3]heptan-2-yl)acetonitrile; 2-(1-((6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidine]-1'-yl)sulfonyl)cyclopropyl)acetonitrile; 2-(1-((6-methoxy-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,3'-pyrrolidine]-1'-yl)methyl)cyclopropyl)acetonitrile; 2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclopentyl)acetonitrile; 2-(1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-1′H,3H-spiro[dipyrrolo[2,3-b:3′,2′-d]pyridine-8,4′-pyridine]-1′-yl)cyclopropyl)acetonitrile; 2-(4-methoxy-1-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclobutyl)acetonitrile; 1'-(2-(1H-1,2,3-triazol-4-yl)propan-2-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidin]-7-one; 1'-(2-(4H-1,2,4-triazol-3-yl)propan-2-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidin]-7-one; 6-methyl-1'-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidin]-7-one; 2-(1-(2-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-6-methyl-1-(1-(methyl-d ３ )-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)cyclopentyl)acetonitrile; (R)-4-Methoxy-3-methyl-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-(1-(methyl-d ３ )-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)butanenitrile; (S)-4-Methoxy-3-methyl-3-(6-methyl-2-(1-methyl-1H-pyrazol-4-yl)-1-(1-(methyl-d ３ )-1H-indazol-5-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)butanenitrile; Methyl 4-(cyanomethyl)-4-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)piperidine-1-carboxylate; N-(3-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)bicyclo[1.1.1]pentan-1-yl)acetamide; Methyl 4-(6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-7-oxo-6,7-dihydro-3H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidine]-1'-yl)-2-azabicyclo[2.1.1]hexane-2-carboxylate; 1'-(2-(azetidin-3-yl)propan-2-yl)-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3,6-dihydro-7H-spiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,4'-piperidin]-7-one; 1-(ethylsulfonyl)-6"-methyl-1"-(1-(methyl-d ３ )-1H-indazol-5-yl)-2″-(4-(morpholinomethyl)phenyl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one; 1-(ethylsulfonyl)-6"-methyl-1"-(1-methyl-1H-indazol-5-yl)-2"-(1-methyl-1H-pyrazol-4-yl)-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 2"-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-6"-methyl-1"-(1-methyl-1H-indazol-5-yl))-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 1-(ethylsulfonyl)-2"-(1-(2-methoxyethyl-1H-pyrazol-4-yl)-6"-methyl-1"-(1-methyl-1H-indazol-5-yl)-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 1-(ethylsulfonyl)-2"-(1-isopropyl-1H-pyrazol-4-yl)-6"-(methyl-d ３ )-1″-(1-methyl-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one; 2"-(1-(cyclopentyl)-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-6"-methyl-1"-(1-methyl-1H-indazol-5-yl)-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 1-(4-(1-(ethylsulfonyl)-6"-methyl-1"-(1-(methyl-d ３ )-1H-indazol-5-yl)-7″-oxo-6″,7″-dihydro-3″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridine]-2″-yl)benzyl)piperidine-4-carbonitrile; 1-(ethylsulfonyl)-1″-(4-methoxyphenyl)-6″-(methyl-d ３ )-2″-(4-(morpholinomethyl)phenyl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one; 2"-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-6"-methyl-1"-(1-methyl-1H-indazol-5-yl)-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 2″-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-(ethylsulfonyl)-6″-methyl-1″-(1-methyl-1H-indazol-5-yl)-3″,6″-dihydro-7″H-dispiro[azetidine-3,1′-cyclobutane-3′,8″-dipyrrolo[2,3-b:3′,2′-d]pyridin]-7″-one; 2"-(1-ethyl-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-1"-(4-methoxyphenyl)-6"-(methyl-d ３ )-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 1-(ethylsulfonyl)-2"-(1-(2-methoxy-2-methylpropyl)-1H-pyrazol-4-yl)-6"-methyl-1"-(1-(methyl-d ３ )-1H-indazol-5-yl)-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 1-(ethylsulfonyl)-6"-methyl-1"-(1-methyl-1H-indazol-5-yl)-2"-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazol-4-yl)-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 2"-(6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-3-yl)-1-(ethylsulfonyl)-6"-methyl-1"-(1-(methyl-d ３ )-1H-indazol-5-yl)-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 1-(ethylsulfonyl)-2"-(3-methoxy-1-methyl-1H-pyrazol-4-yl)-6"-methyl-1"-(1-(methyl-d ３ )-1H-indazol-5-yl)-3",6"-dihydro-7"H-dispiro[azetidine-3,1'-cyclobutane-3',8"-dipyrrolo[2,3-b:3',2'-d]pyridin]-7"-one; 1-(2-amino-2-oxoethyl)-N-((1S,3S)-6'-methyl-2'-(1-methyl-1H-pyrazol-4-yl)-1'-(1-methyl-d ３ )-1H-indazol-5-yl)-7'-oxo-6',7'-dihydro-3'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-3-yl)cyclobutane-1-carboxamide; 1-(2-amino-2-oxoethyl)-N-((1R,3R)-6'-methyl-2'-(1-methyl-1H-pyrazol-4-yl)-1'-(1-(methyl-d ３ )-1H-indazol-5-yl)-7'-oxo-6',7'-dihydro-3'H-spiro[cyclopentane-1,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-3-yl)cyclobutane-1-carboxamide; 1"-Butyryl-6-methyl-1-(1-methyl-1H-indazol-5-yl)-2-(1-methyl-d ３ )-1H-pyrrol-3-yl)-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,1'-cyclobutane-3',4"-piperidin]-7-one; 1"-Butyryl-6-methyl-1-(1-(methyl-d ３ )-1H-indazol-5-yl)-2-(1-(methyl-d ３ )-1H-pyrrol-3-yl)-3,6-dihydro-7H-dispiro[dipyrrolo[2,3-b:3',2'-d]pyridine-8,1'-cyclobutane-3',4"-piperidin]-7-one; 2'-(1-isopropyl-1H-pyrazol-4-yl)-6'-(methyl-d ３ )-1'-(1-methyl-1H-indazol-5-yl)-1-((1-methylcyclopropyl)sulfonyl)-3',6'-dihydro-7'H-spiro[azepane-4,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one; and 2'-(1-(1-cyclopropylethyl)-1H-pyrazol-4-yl)-1-(ethylsulfonyl)-6'-(methyl-d ３ )-1'-(1-methyl-1H-indazol-5-yl)-3',6'-dihydro-7'H-spiro[azepane-4,8'-dipyrrolo[2,3-b:3',2'-d]pyridin]-7'-one 2. The compound of claim 1, selected from:

61. 61. The compound of any one of claims 1 to 60, or a pharma- ceutically acceptable salt thereof, wherein the compound is deuterated.

62. 62. A pharmaceutical composition comprising a compound according to any one of claims 1 to 61, or a pharma- ceutically acceptable salt thereof, and a pharma- ceutically acceptable carrier.

63. A pharmaceutical composition for inhibiting the activity of the V617F variant of JAK2 kinase, comprising a compound according to any one of claims 1 to 61, or a pharma- ceutically acceptable salt thereof.

64. A pharmaceutical composition for treating cancer in a patient in need thereof, comprising a compound according to any one of claims 1 to 61, or a pharma- ceutically acceptable salt thereof.

65. 65. The pharmaceutical composition of claim 64, wherein the cancer is selected from bladder cancer, breast cancer, cervical cancer, large intestine cancer, small intestine cancer, colon cancer, rectal cancer, anal cancer, endometrial cancer, gastric cancer, head and neck cancer, kidney cancer, liver cancer, lung cancer, ovarian cancer, prostate cancer, testicular cancer, uterine cancer, vulvar cancer, esophageal cancer, gallbladder cancer, pancreatic cancer, stomach cancer, thyroid cancer, parathyroid cancer, neuroendocrine cancer, skin cancer, and brain cancer.

66. 65. The pharmaceutical composition of claim 64, wherein the cancer is a hematological cancer.

67. 65. The pharmaceutical composition of claim 64, wherein the cancer is selected from leukemia, lymphoma, multiple myeloma, chronic lymphocytic lymphoma, adult T-cell leukemia, acute myeloid leukemia, B-cell lymphoma, cutaneous T-cell lymphoma, acute myeloid leukemia, Hodgkin's or non-Hodgkin's lymphoma, myeloproliferative neoplasms, myelodysplastic syndromes, chronic eosinophilic leukemia, Waldenstrom's macroglobulinemia, hairy cell lymphoma, chronic myeloid lymphoma, acute lymphoblastic lymphoma, AIDS-related lymphoma, and Burkitt's lymphoma.

68. A pharmaceutical composition for treating a myeloproliferative disorder in a patient in need thereof, comprising a compound according to any one of claims 1 to 61, or a pharma- ceutically acceptable salt thereof.

69. 69. The pharmaceutical composition of claim 68, wherein the myeloproliferative disorder is selected from polycythemia vera, essential thrombocythemia, myelofibrosis with myeloid metaplasia, primary myelofibrosis, post-essential thrombocythemia myelofibrosis, post-polycythemia vera myelofibrosis, chronic myelogenous leukemia, chronic myelomonocytic leukemia, hypereosinophilic syndrome, and systemic mast cell disease.

70. A pharmaceutical composition for treating myelodysplastic syndrome in a patient in need thereof, comprising a compound according to any one of claims 1 to 61, or a pharma- ceutically acceptable salt thereof.

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