Aerosol-generating article having a biomarker sensor

Abstract

The present invention relates to an aerosol-generating article comprising an aerosol-forming substrate. The aerosol-generating article comprises an oral end, a distal end, and a biomarker sensor, the biomarker sensor being provided on the aerosol-generating article and being at least one centimeter away from the oral end. The present invention also relates to an aerosol generating device, and an aerosol generating system comprising the aerosol generating device and the aerosol-generating article. The present invention also relates to a method of operating such an aerosol generating system.

Description

[Technical field]

[0001] The present invention relates to an aerosol-generating article comprising a mouthpiece and a biomarker sensor. The present invention also relates to an aerosol-generating device for receiving such an aerosol-generating article, and to a system comprising the aerosol-generating article and the aerosol-generating device. The present invention further relates to a method of using such a system. [Background technology]

[0002] The present disclosure generally relates to an aerosol-generating article including a biomarker sensor. The aerosol-generating article may be used with an aerosol generating device. The biomarker sensor may be read by corresponding control electronics of the aerosol generating device. In this manner, feedback may be provided that may be used to tailor the user experience. For example, nicotine delivery may be controlled based on a measured biomarker concentration in the user's saliva. The measured biomarker concentration may preferably be related to the user's nicotine exposure level.

[0003] Biomarkers such as nicotine or its metabolic derivatives, such as cotinine or 3-hydroxy-cotinine, may be used to determine how intensely a user has previously used tobacco products or nicotine-delivering aerosol generators. Some metabolic derivatives may be detectable in a user's saliva for more than 40 hours after use.

[0004] Therefore, by monitoring biomarker levels in a user of a nicotine delivery product, nicotine intake can be monitored and may subsequently affect the user's experience. Incentives may be provided to keep the user's nicotine intake at a constant or continuously decreasing level.

[0005] It would be desirable to provide an aerosol generating article for use in an aerosol generating system that offers increased functionality, particularly with respect to monitoring the behavior of a user.

[0006] It would be desirable to provide an aerosol generating article for use in an aerosol generating system that provides such increased functionality, and which is easy to handle. It would be desirable to provide an aerosol generating system that can be used for extended periods of time, and at the same time provides high standards of hygiene.

[0007] It would further be desirable to provide an aerosol generating system comprising an aerosol generating article that can be manufactured at reduced cost. Summary of the Invention

[0008] According to an embodiment of the invention, there is provided an aerosol-generating article comprising an aerosol-forming substrate, the aerosol-generating article having an oral end and a distal end, the aerosol-generating article comprising a biomarker sensor provided to the aerosol-generating article and spaced at least one centimeter from the oral end.

[0009] During the user experience, the mouth end of the aerosol-generating article is placed into the user's mouth. The biomarker sensor is positioned so that it is not in direct contact with the user's mouth. In this manner, the biomarker sensor may be visible throughout the user experience. Specifically, the biomarker sensor may be read by the user or by electronics during the user experience.

[0010] The aerosol-generating article may comprise a dedicated mouthpiece at the oral end of the aerosol-generating article. The mouthpiece is the part of the aerosol-generating article that may be placed in the user's mouth during the user experience. The biomarker sensor may be provided away from the mouthpiece. The biomarker sensor may be provided upstream from the mouthpiece. Positioning the biomarker sensor away from the mouthpiece may effectively ensure that the biomarker does not come into contact with the user's mouth.

[0011] The aerosol-generating article may include a part in which the aerosol-forming substrate is provided. The biomarker sensor may be located in the part in which the aerosol-forming substrate is provided. The part in which the aerosol-forming substrate is provided may not be placed into the user's mouth during the user experience. As a result, by positioning the biomarker sensor in the part in which the aerosol-forming substrate is provided, it may again be effectively ensured that the biomarker does not come into contact with the user's mouth.

[0012] The aerosol-generating article may comprise perforations. The aerosol-generating article may comprise a perforation line. The biomarker sensor may be provided upstream from the perforation line. The perforation line is provided in the aerosol-generating article to allow ambient air to be introduced into the airflow channel of the aerosol-generating article. To fulfill this function, the perforation line is typically not covered during the user experience. In particular, the perforation line is typically not covered by the user's mouth during the user experience. Hence, in this way too, it may be efficiently ensured that the biomarker does not come into contact with the user's mouth.

[0013] As used herein, "aerosol generating device" refers to a device that interacts with an aerosol-forming substrate to generate an aerosol. For example, the aerosol-forming substrate may be part of an aerosol-generating article. The generated aerosol may be an aerosol that is directly inhalable through the user's mouth into the user's lungs. The aerosol generating device may be a holder. The aerosol generating device may be an electrically heated aerosol generating device. The aerosol generating device may comprise an electrical circuit. The aerosol generating device may comprise a power source. The aerosol generating device may comprise a heating chamber. The aerosol generating device may comprise a heating element. The electrical circuit and the power source are preferably disposed within the main body of the aerosol generating device.

[0014] As used herein, the term "aerosol-generating article" refers to an article that includes an aerosol-forming substrate capable of releasing a volatile compound capable of forming an aerosol. For example, the aerosol-generating article may be an aerosol-generating article that generates an aerosol that is directly inhalable through the user's mouth into the user's lungs. The aerosol-generating article may be disposable. An aerosol-generating article that includes an aerosol-forming substrate that includes tobacco may be referred to as a tobacco stick.

[0015] The aerosol-generating article may be substantially cylindrical in shape. The aerosol-generating article may be substantially elongated. The aerosol-generating article may have a length and a perimeter substantially perpendicular to the length. The aerosol-forming substrate may be substantially cylindrical in shape. The aerosol-forming substrate may be substantially elongated. The aerosol-forming substrate may also have a length and a perimeter substantially perpendicular to the length.

[0016] The aerosol-generating article may have an overall length of about 30 mm to about 100 mm. The aerosol-generating article may have an outer diameter of about 5 mm to about 12 mm. The aerosol-generating article may comprise a filter plug. The filter plug may be located at a downstream end of the aerosol-generating article. The filter plug may be a cellulose acetate filter plug. In one embodiment the filter plug is about 7 mm long, but may have a length of about 5 mm to about 10 mm.

[0017] In one embodiment, the aerosol-generating article may have an overall length of approximately 45 mm. The aerosol-generating article may have an outer diameter of approximately 7.2 mm. Further, the aerosol-forming substrate may have a length of approximately 10 mm. Alternatively, the aerosol-forming substrate may have a length of approximately 12 mm. Further, the diameter of the aerosol-forming substrate may be between approximately 5 mm and approximately 12 mm. The aerosol-generating article may comprise an outer paper wrapper. Further, the aerosol-generating article may comprise a separation between the aerosol-forming substrate and the filter plug. The separation may be approximately 18 mm, but may be within the range of approximately 5 mm to approximately 25 mm.

[0018] The heating chamber of the aerosol generating device may have an elongated shape. The heating chamber of the aerosol generating device may have a cross-section that corresponds to the cross-section of the aerosol-generating article that is used with and inserted into the heating chamber of the aerosol generating device.

[0019] As used herein, the term "aerosol-forming substrate" relates to a substrate capable of releasing volatile compounds capable of forming an aerosol. Such volatile compounds may be released by heating the aerosol-forming substrate. The aerosol-forming substrate may conveniently be part of an aerosol-generating article.

[0020] The aerosol-forming substrate may be a solid aerosol-forming substrate or a liquid aerosol-forming substrate. Alternatively, the aerosol-forming substrate may comprise both solid and liquid components. The aerosol-forming substrate may comprise a tobacco-containing material that contains volatile tobacco flavor compounds that are released from the substrate upon heating. Alternatively, the aerosol-forming substrate may comprise a non-tobacco material. The aerosol-forming substrate may further comprise an aerosol former that facilitates the formation of a dense and stable aerosol. Examples of suitable aerosol formers are glycerin and propylene glycol.

[0021] An aerosol-forming substrate is a substrate capable of releasing a volatile compound capable of forming an aerosol. The volatile compound may be released by heating the aerosol-forming substrate.

[0022] The aerosol generating device may comprise an electric circuit. The electric circuit may comprise a microprocessor, which may be a programmable microprocessor. The microprocessor may be part of the controller. The electric circuit may comprise further electronic components. The electric circuit may be configured to regulate the supply of power to the heating element. Power may be supplied to the heating element continuously following activation of the aerosol generating device, or may be supplied intermittently, such as after every puff. Power may be supplied to the heating element in the form of current pulses. The electric circuit may be configured to monitor the electrical resistance of the heating element, and to control the supply of power to the heating element, preferably depending on the electrical resistance of the heating element.

[0023] The aerosol generating device may include a power source (typically a battery) within the main body of the aerosol generating device. In one embodiment, the power source is a lithium ion battery. Alternatively, the power source may be a nickel metal hydride battery, a nickel cadmium battery, or a lithium-based battery (e.g., a lithium cobalt battery, a lithium iron phosphate battery, a lithium titanate battery, or a lithium polymer battery). Alternatively, the power source may be another form of charge storage device, such as a capacitor. The power source may require recharging and may have a capacity that allows for storage of sufficient energy for one or more use experiences, for example, the power source may have a capacity sufficient to continuously generate aerosol for a period of approximately 6 minutes, or a multiple of 6 minutes. In another embodiment, the power source may have a capacity sufficient to provide a predetermined number of puffs, or discontinuous activation of the heating element.

[0024] The aerosol generating device may comprise an atomizer. The atomizer is provided to atomize the liquid aerosol-forming substrate to form an aerosol that can then be inhaled by the user. The atomizer may comprise a heating element, in which case the atomizer is referred to as a vaporizer. In general, the atomizer may be configured as any device capable of atomizing the liquid aerosol-forming substrate. For example, the atomizer may comprise a nebulizer or atomizer nozzle based on the Venturi effect to atomize the liquid aerosol-forming substrate. Thus, the atomization of the liquid aerosol-forming substrate may be achieved by non-thermal aerosolization techniques. Mechanically vibrating vaporizers with vibrating elements, vibrating meshes, piezoelectrically driven nebulizers, or surface acoustic wave aerosolization may be used.

[0025] The atomizer is preferably configured as a vaporizer comprising a heater for heating a dispensed amount of the liquid aerosol-forming substrate. The heater may be any device suitable for heating the liquid aerosol-forming substrate and vaporizing at least a portion of the liquid aerosol-forming substrate to form an aerosol. The heater may be exemplarily a coil heater, a capillary heater, a mesh heater, or a metal plate heater. The heater may be exemplarily a resistive heater that receives electrical power and converts at least a portion of the received electrical power into thermal energy. Alternatively or additionally, the heater may be a susceptor that is inductively heated by a time-varying magnetic field. The heater may comprise only a single heating element or may comprise multiple heating elements. The temperature of the single or multiple heating elements is preferably controlled by an electric circuit.

[0026] As used herein, the terms "upstream," "downstream," "proximal," "distal," "forward," and "rearward" are used to describe the relative position of a component or portion of a component of an aerosol generating device with respect to the direction of airflow caused by a user inhaling into the mouthpiece of the aerosol generating device during use thereof.

[0027] The biomarker sensor may be provided in any suitable form and shape. The biomarker sensor may be provided with a test patch on the outer surface of the aerosol-generating article. The test patch may be adhered to the outer surface of the aerosol-generating article with an adhesive or any other suitable attachment means.

[0028] The biomarker sensor may be provided in the form of a band extending around the circumference of the aerosol-generating article. Such a design may be particularly advantageous for aerosol-generating articles having a cylindrical shape. A biomarker sensor provided in the form of a band may be securely fixed to the aerosol-generating article using conventional attachment methods. A biomarker sensor extending around the circumference of the aerosol-generating article may be easily observable by the user throughout the user experience or by a corresponding readout means.

[0029] The biomarkers may be used to examine any oral fluids derived from the user's mouth. Such oral fluids may primarily include saliva, but may also include, for example, condensation of the user's breath. For clarity, the term saliva is used in this document as an example of any oral fluid.

[0030] The biomarker sensor may employ any suitable biomarker detection technology. Known technologies for detecting biomarker concentrations in a user's saliva include colorimetry, gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS), high performance liquid chromatography (HPLC), and radioimmunoassay (RIA). Lateral flow test strips, such as lateral flow contact point chromatography saliva biomarker detection systems, may also be used. These biomarker detection technologies or other suitable technologies may be adapted for use in the present invention.

[0031] The biomarker sensor may include a material having a property that changes upon contact with a corresponding biomarker in the user's saliva. The biomarker sensor may contain a material including one or more of nanoparticles, dyes, and chemicals. The biomarker sensor may contain a material that leads to a change in a physical property when the presence of a particular biomarker in the user's saliva is detected. The material in the biomarker sensor may be a colorimetric material configured to change its color upon contact with a biomarker present in the user's saliva.

[0032] Chromophore-generating reagents useful in such colorimetric methods may include barbituric acid (BA), 1,3-diethyl-2-thiobarbituric acid (DETBA), and Meldrum's acid (MA). Cotinine equivalent measurements may use cyanide and chromophore-generating reagents (e.g., BA, MA, DETBA) to determine pyridine derivatives (specifically nicotine metabolites). BA is known for use with some pyridine derivatives for such colorimetric quantification of cyanide. Colorimetric nicotine metabolite (such as cotinine) assays may use pyrazolones as chromophore-generating agents. Such assays may be used to not only detect but also quantitatively measure nicotine-metabolite concentrations (such as cotinine concentrations) in a user's saliva.

[0033] The color change may be visually observed by the user. In this way, the user may obtain confirmation of the authenticity of the aerosol-generating article. The biomarker sensor may be used for prevention or detection of product counterfeiting. The material may be provided with a predefined and easily recognizable pattern, such as a brand logo, a QR code, a barcode, or another visual code, that allows the user to verify the integrity and authenticity of the product.

[0034] The biomarker sensor may be a sensor that responds to any biomarker present in the user's saliva. Suitable biomarkers include, but are not limited to, nicotine metabolites or cortisol metabolites.

[0035] Any one or more of the sensors may be configured to detect any one or more nicotine metabolites in the user's saliva, including, but not limited to, nicotine glucuronide, nicotine N'-oxide, nicotine isomethonium ion, cotinine methonium ion, cotinine glucuronide, 3-pyridylacetic acid, nicotine-Δiminium ion, cotinine, cotinine N-oxide, 4-(3-pyridyl)-butanoic acid, 2;-hydroxynicotine, nornicotine, N'-hydroxymethylnornicotine, 5'-hydroxycotinine, 7rans-3'-hydroxycotinine, 4-(methanamine), 5'-hydroxycotinine, 5'-hydroxymethylnornicotine, ... 4-oxo-4-(3-pyridyl)-butanamide, 4-oxo-4-(3-pyridyl)-N-methylbutanamide, frans-3'-hydroxycotinine glucuronide, 4-(3-pyridyl)-3-butenoic acid, 4-hydroxy-4-(3-pyridyl)-butanoic acid, 4-oxo-4-(3-pyridyl)-butanoic acid, and 5-(-3-pyridyl)-tetrahydro-furan-2-one. At least one sensor may be configured to detect cotinine levels.

[0036] Cotinine is the preferred metabolite, in part because it has a long plasma half-life and because a high percentage of nicotine is converted to cotinine. For example, cotinine typically has a plasma half-life of about 11 hours to about 37 hours, compared to about 30 minutes for nicotine. In addition, about 70 percent to about 80 percent of nicotine is converted to cotinine in the liver and delivered to the bloodstream. Furthermore, the salivary concentration of cotinine is believed to be proportional to the plasma cotinine concentration.

[0037] The biomarker sensor may be configured to quantify the amount of cotinine within a relevant concentration range. As an example, studies have shown that passive exposure to nicotine-containing aerosols results in salivary cotinine concentrations below 5 nanograms per milliliter, while heavy passive exposure may result in salivary concentrations of 10 nanograms per milliliter. Cotinine concentrations in the saliva of regular users may range from about 10 nanograms per milliliter to about 100 nanograms per milliliter. As a result, and preferably, the sensor may be configured to accurately quantify salivary concentrations of cotinine within a range of about 5 nanograms per milliliter to about 200 nanograms per milliliter, such as about 10 nanograms per milliliter to about 150 nanograms per milliliter. However, it will be appreciated that the reliability and sensitivity range of the sensor may be adjusted to include other concentration ranges as needed or desired.

[0038] The biomarker sensor may include a biological material that acts as a binding or detection partner for nicotine metabolites. Such biological material is generally referred to herein as an antibody to a nicotine metabolite. How such an antibody can be prepared is known in the prior art. Exemplarily, reference is made herein to U.S. Pat. No. 5,164,504 (antibodies for immunoassays for cotinine derivatives), U.S. Patent Application No. 2011 / 305715 (antibodies for 3-hydroxycotinine), and U.S. Pat. No. 7,517,699 (lateral flow cotinine immunoassay), all of which are incorporated herein by reference in their entirety to the extent not inconsistent with the present disclosure.

[0039] Sensor technologies that can be employed to achieve or approximate the above-mentioned results are described, for example, by Francesco Riccia, b, Gianluca Adornettoa, Giuseppe Palleschia, ELECTROCHEMICAL SCIENCE AND TECHNOLOGY State of the Art and Future Perspectives On the occasion of the International Year of Chemistry (2011); Electrochimica Acta; Volume 84, 1 December 2012, Pages 74-83, which is incorporated by reference in its entirety herein to the extent not inconsistent with the present disclosure. Further description of suitable sensor technologies can be found in Ashlesha Bhide, et al., “Next-Generation Continuous Metabolite Sensing toward Emerging Sensor Needs”, ACS Omega 2021, 6, 6031-6040, in Shikha Sharma et al., “Antibodies and antibody-derived analytical biosensors”, Essays in Biochemistry (2016) 60 9-18, and Nikhil Bhalla et al., Introduction to biosensors Essays in Biochemistry (2016) 60 1-8, all of which are incorporated by reference in their entirety herein to the extent not inconsistent with this disclosure.

[0040] The aerosol-generating article may comprise multiple biomarker sensors. The biomarker sensors may all respond to the same biomarker. The sensors may respond to different biomarkers. By using multiple biomarker sensors, a biomarker signature or molecular signature may be obtained.

[0041] To provide saliva to the biomarker sensor, the user may be required to use the tongue to lick the cigarette paper or biomarker strip. Licking the biomarker strip or cigarette paper allows the user's saliva to be directly absorbed and made available for chemical reaction at the biomarker sensor. An optically visible change in color of the biomarker sensor may be perceived immediately after application of the user's saliva.

[0042] The user's saliva may also be transported to the biomarker sensor during normal use of the aerosol-generating article, and to this end, the aerosol-generating article may be provided with one or more capillary channels extending between the biomarker sensor and the oral end of the aerosol-generating article.

[0043] The mouth end of the aerosol-generating article is placed into the user's mouth during the user experience, such that a capillary channel extending from the mouth end of the aerosol-generating article may be advantageously used to transport saliva from the user's mouth towards a biomarker sensor in the aerosol-generating article.

[0044] When multiple biomarker sensors are used, multiple capillary channels may be employed, each of which may be operatively coupled to one of the biomarker sensors.

[0045] The aerosol-generating article may be elongate and may define a longitudinal axis. The one or more capillary channels may extend in a direction substantially parallel to the longitudinal axis of the aerosol-generating article.

[0046] The capillary channel may be formed as a hollow tube.The capillary channel may be formed from a polymeric or composite material.

[0047] The diameter of the capillary channel may be in the range of 0.001 to 1.0 millimeters. The diameter of the capillary channel may be in the range of 0.01 to 0.5 millimeters. The diameter of the capillary channel may be in the range of 0.01 to 0.1 millimeters. The diameter of the capillary channel may depend on the fluid material being transported by capillary action. Low viscosity materials generally require smaller diameter capillaries to achieve sufficiently fast transport.

[0048] A capillary channel may be a hollow channel having a non-circular internal cross-section. The diameter of such a non-circular capillary channel is understood to be the cross-sectional dimension that has the largest extension.

[0049] The aerosol-generating article may comprise three, four or five capillary channels. The capillary channels may have the same dimensions. The capillary channels may be of different lengths. The capillary channels may be of different diameters. The capillary channels may be of different lengths and diameters.

[0050] The aerosol-generating article may comprise a mouthpiece. The mouthpiece may comprise a mouthpiece core surrounded by a wrapper, a tipping paper, or by both a wrapper and a tipping paper. The wrapper and tipping paper may be formed from any suitable material or combination of materials. The wrapper or tipping paper may be formed from paper, a laminated paper, or a cellulosic material. The wrapper or tipping paper may be formed from cigarette paper.

[0051] The mouthpiece core may be formed from materials commonly used in the manufacture of cigarette filters. The mouthpiece core may comprise a filter. The filter may be formed from one or more suitable filtration materials. Many such filtration materials are known in the art. In one embodiment, the mouthpiece core may comprise a filter formed from cellulose acetate tow. The mouthpiece core may comprise a hollow acetate tube.

[0052] The mouthpiece may have an outer diameter approximately equal to the outer diameter of the aerosol-generating article.

[0053] The mouthpiece may have an outer diameter of about 5 millimeters to about 10 millimeters in diameter.

[0054] The mouthpiece may have a length of about 5 millimeters to about 20 millimeters.

[0055] The mouthpiece may include a capillary channel. The mouthpiece core and the capillary channel may be surrounded by a wrapper.

[0056] The capillary channels may extend in a direction generally parallel to the longitudinal axis of the mouthpiece, and may be positioned radially between the mouthpiece core and the wrapper.

[0057] The aerosol-generating article may comprise further components upstream from the mouthpiece. Such further components may include a portion having a sensory medium. The biomarker sensor may be provided in any portion of the aerosol-generating article other than the mouthpiece. A capillary channel may extend from the mouth end of the aerosol-generating article to where the biomarker sensor is located.

[0058] The biomarker sensor may be provided in a sensory media portion of the aerosol-generating article. A capillary channel may extend from the mouth end of the aerosol-generating article to the biomarker sensor positioned within the sensory media portion.

[0059] By providing the biomarker sensor in a location that is not accessible to the user's mouth, it may be ensured that the response of the biomarker sensor to exposure to the user's saliva can be visually inspected by the user throughout the user experience.

[0060] The biomarker sensor may be provided on an outer surface of the aerosol-generating article, thus ensuring that the biomarker sensor can be visually inspected by the user or by a corresponding sensor arrangement throughout the user experience.

[0061] The biomarker sensor may also be covered by one or more layers of transparent, translucent, or perforated material, which may be useful to protect the biomarker sensor during handling of the aerosol-generating article.

[0062] To still allow the user's saliva to reach the biomarker sensor, the outer wrapping material of the aerosol-generating article may be configured as a paper microfluidic device. Such a paper microfluidic device may include the use of hydrophilic cellulose fibers provided between hydrophobic barriers. Such a paper microfluidic device may transport fluids by capillary forces, which are also well known in the art. Paper microfluidic devices may be prepared by wax printing, inkjet printing, photolithography, flexography, plasma treatment, laser treatment, wet etching, screen printing, or wax screen printing. The manufacture of such a paper microfluidic device may also include multiple paper layers that are stacked to form a 3D arrangement of capillary channels.

[0063] The thickness of the layers of transparent, translucent, or perforated material should be configured such that the biomarker sensor can still be visually inspected by a user or by a corresponding sensor arrangement. The overall thickness of these layers may be less than 1.0 millimeter. The overall thickness of these layers may be less than 0.1 millimeter.

[0064] The present invention also relates to an aerosol generating device comprising a cavity for receiving an aerosol-generating article as described above. The cavity may form a heating chamber of the aerosol generating device. The aerosol generating device may comprise a sensor arrangement configured to detect a change in a property of the biomarker sensor. The sensor arrangement of the aerosol generating device may comprise an optical sensor configured to detect a colorimetric change in the biomarker sensor.

[0065] The sensor arrangement of the aerosol generating device may be positioned such that, in use, the biomarker sensor can be read out when the aerosol-generating article is inserted into the cavity of the aerosol generating device.

[0066] If the biomarker sensor is provided in the form of a test patch that does not extend around the entire circumference of the aerosol-generating article, it is necessary to ensure that the aerosol-generating article is inserted into the cavity of the aerosol-generating device in the correct rotational orientation to ensure that the sensor arrangement and the biomarker sensor are located at a readout position adjacent to each other. Alternatively, the sensor arrangement may be provided such that the entire circumference of the aerosol-generating article can be monitored. In such a case, it is only necessary that the aerosol-generating article is inserted in such a way that the axial position of the biomarker sensor corresponds to the axial position of the sensor arrangement. In this case, the biomarker sensor can be read independently of the rotational orientation of the aerosol-generating article.

[0067] If the biomarker sensor is provided in the form of a band extending around the entire circumference of the aerosol-generating article, the biomarker sensor can also be read out independent of the rotational orientation of the aerosol-generating article, which may facilitate handling of the aerosol-generating device.

[0068] Suitable sensor arrangements for reading out biomarker sensors are well known to those skilled in the art and need not be described in more detail herein. In particular, sensor arrangements for reading out colorimetric data of biomarker sensors are known in this regard. Optical sensor arrangements may include a camera for determining a color change of the biomarker sensor. Such optical sensor arrangements may be able to determine a color change of the biomarker sensor and thus determine whether a given biomarker is present in the user's saliva. Such optical sensor arrangements may also be used to determine a quantification of the color change of the biomarker sensor and thereby determine the concentration level of the biomarker in the user's saliva.

[0069] The aerosol generating device may comprise a control unit operatively coupled to the sensor arrangement. The control unit may be configured to use data provided by the sensor arrangement to control operation of the aerosol generating device. The control unit may be configured to control operation of the aerosol generating device based on biomarker concentration levels obtained by the biomarker sensor in the aerosol-generating article.

[0070] By evaluating the biomarker data provided by the sensor arrangement, the control of the aerosol generating device can be adapted to the determined biomarker data or the determined biomarker signature. In this way, the individual user experience can be enhanced. For example, nicotine delivery can be adjusted based on the biomarker data. If the biomarker data indicates a significant biomarker level, the operation of the aerosol generating device can be limited or prevented.

[0071] The present invention also relates to an aerosol generating system comprising an aerosol generating article and an aerosol generating device as described above.

[0072] The present invention also relates to a method of operating an aerosol generating system. The method may comprise the step of inserting an aerosol-generating article as described above into an aerosol generating device. The aerosol generating device comprises a control unit operatively linked to the sensor arrangement for reading out the biomarker sensor of the aerosol-generating article. Operation of the aerosol generating device may be controlled based on the biomarker concentration level determined by the biomarker sensor of the aerosol-generating article.

[0073] Below is provided a non-exhaustive list of non-limiting examples, any one or more of the features of these examples may be combined with any one or more features of the other examples, embodiments, or aspects described herein. Example 1

[0074] An aerosol-generating article comprising an aerosol-forming substrate, An aerosol-generating article comprising an oral end and a distal end, and a biomarker sensor, the biomarker sensor being provided on the aerosol-generating article and at least 1 centimeter away from the oral end. Example 2

[0075] An aerosol-generating article according to Example 1, further comprising a mouthpiece at the oral end, and a biomarker sensor provided separate from the mouthpiece. Example 3

[0076] The aerosol-generating article according to any preceding embodiment, further comprising a portion provided with an aerosol-forming substrate, and wherein the biomarker sensor is located in the portion provided with the aerosol-forming substrate. Example 4

[0077] An aerosol-generating article according to any preceding embodiment, further comprising a perforation, and wherein a biomarker sensor is provided upstream from the perforation. Example 5

[0078] The aerosol-generating article according to any preceding embodiment, wherein the biomarker sensor is a test patch provided on an outer surface of the aerosol-generating article. Example 6

[0079] An aerosol-generating article according to any preceding embodiment, wherein the aerosol-generating article has a cylindrical shape and the biomarker sensor is provided in the form of a band around the circumference of the aerosol-generating article. Example 7

[0080] An aerosol-generating article according to any preceding embodiment, wherein the biomarker sensor comprises a material having properties that change upon contact with a corresponding biomarker in the user's saliva. Example 8

[0081] The aerosol-generating article according to any preceding embodiment, wherein the substrate in the nicotine metabolite sensor comprises one or more of a dye and a chemical. Example 9

[0082] The aerosol-generating article according to any preceding embodiment, wherein the substrate within the biomarker sensor is a colorimetric material configured to change its color upon contact with nicotine or nicotine metabolites present in the user's saliva. Example 10

[0083] An aerosol-generating article according to any preceding embodiment, comprising one or more capillary channels extending between the biomarker sensor and the oral end of the aerosol-generating article. Example 11

[0084] An aerosol-generating article according to any preceding embodiment, wherein the one or more capillary channels may be polymeric or composite tubes having an inner diameter of less than 0.1 millimeters, preferably less than 0.01 millimeters. Example 12

[0085] An aerosol-generating article according to any preceding embodiment, comprising a mouthpiece and a capillary channel extending along a length of the mouthpiece. Example 13

[0086] An aerosol-generating article according to any preceding embodiment, wherein the mouthpiece comprises a mouthpiece core material and a capillary channel, the mouthpiece core material and the capillary channel being surrounded by a wrapper. Example 14

[0087] An aerosol-generating article according to any preceding embodiment, wherein the capillary channels are positioned radially between the mouthpiece core material and the wrapper. Example 15

[0088] An aerosol-generating article according to any preceding embodiment, wherein the biomarker sensor is positioned such that it can be visually inspected by a user. Example 16

[0089] The aerosol-generating article according to any preceding embodiment, wherein the biomarker sensor is positioned on an outer surface of the aerosol-generating article. Example 17

[0090] The aerosol-generating article according to any preceding embodiment, wherein the biomarker sensor is covered by one or more layers of transparent, translucent, or perforated material. Example 18

[0091] An aerosol-generating article according to any preceding embodiment, wherein multiple biomarker sensors are used, the biomarker sensors responding to the same or different biomarkers. Example 19

[0092] An aerosol generating device comprising a cavity for receiving an aerosol-generating article according to any preceding embodiment, wherein the aerosol generating device comprises a sensor configured to detect a change in a characteristic of the biomarker sensor. Example 20

[0093] An aerosol generating device according to Example 19, wherein the aerosol generating device comprises an optical sensor configured to detect a colorimetric change in the biomarker sensor. Example 21

[0094] An aerosol generating system comprising an aerosol generating article according to any one of Examples 1 to 18 and an aerosol generating device according to any one of Examples 19 to 20. Example 22

[0095] An aerosol generating system according to Example 21, wherein the aerosol generating device is operably coupled to the sensor and comprises a control unit that controls operation of the aerosol generating device based on the biomarker concentration level obtained by the biomarker sensor in the aerosol-generating article. Example 23

[0096] A method of operating an aerosol generating system according to Example 21 or 22, wherein the aerosol generating device comprises a control unit operably coupled to the sensor, and the operation of the aerosol generating device is controlled based on the biomarker concentration level obtained by the biomarker sensor in the aerosol-generating article.

[0097] Features described with respect to one embodiment may equally be applied to other embodiments of the invention.

[0098] The invention will now be further described, by way of example only, with reference to the accompanying drawings in which: [Brief description of the drawings]

[0099] [Figure 1] FIG. 1 shows an aerosol-generating article having capillary channels. [Diagram 2] FIG. 2 shows an aerosol-generating article having a biomarker sensor. [Diagram 3] FIG. 3 shows an aerosol generating device of the present invention. [Figure 4] FIG. 4 shows an aerosol-generating article having perforations. [Diagram 5] FIG. 5 shows an aerosol-generating article having filter tipping paper. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0100] Figure 1 shows an aerosol-generating article 10 in an embodiment of the present invention. As shown in Figure 1A, the cylindrical aerosol-generating article 10 comprises a sensory media portion 12 and a mouthpiece portion 14. The mouthpiece portion 14 may be provided at a mouth end 16 of the aerosol-generating article 10. Both portions are wrapped around and interconnected by a wrapper 18.

[0101] Capillary channels 20 are provided along the length of the aerosol-generating article 10. These capillary channels 20 are hollow polymeric tubes having an inner diameter of 0.01 millimeters. The capillary channels are provided outside the periphery of the sensory medium portion 12 and the mouthpiece portion 14, and are sandwiched between these portions 12, 14 and a wrapper 16. The wrapper 18 is made from conventional cigarette paper.

[0102] Provided perpendicular to the capillary channel 20 is a biomarker sensor 22. In this case, the biomarker sensor 22 comprises a pyrazolone, which is useful for determining nicotine and cotinine concentrations in a user's saliva.

[0103] The biomarker sensor 22 is provided in the form of a band extending around the entire circumference of the aerosol-generating article 10. The biomarker sensor 22 is operatively coupled to the capillary channel 20. Fluid, particularly a user's saliva, may enter into the capillary channel 20 from the mouth end 16 when the aerosol-generating article 10 is placed in the user's mouth during a user experience.

[0104] Figure IB shows a fully rolled aerosol-generating article 10. The wrapper is provided with different colors to distinguish between the sensory media portion 12 and the mouthpiece portion 14 of the aerosol-generating article 10. As illustrated in Figure IB, a biomarker sensor 22 is provided in the sensory media portion 12 of the aerosol-generating article 10. Unless nicotine or cotinine is detected at the biomarker sensor 22, the biomarker sensor 22 is colorless and cannot be discerned on the aerosol-generating article 10.

[0105] During use of the aerosol-generating article 10, the mouthpiece portion is placed in the mouth of a user. Physical contact of the aerosol-generating article 10 with the user's mouth allows saliva to enter into the capillary channel 20. The saliva is drawn by capillary action towards and onto the biomarker sensor 22. If the user's saliva contains nicotine or cotidine, these biomarkers react with the pyrazolones of the biomarker sensor and cause the biomarker sensor 22 to change color, as shown diagrammatically in FIG. 1C. This color change can be visually determined by the user and may be detected by a corresponding sensor arrangement in the aerosol generating device.

[0106] Figure 2 shows an alternative arrangement of an aerosol-generating article 10 of the present invention. The aerosol-generating article 10 largely corresponds to the aerosol-generating article 10 of Figure 1. The aerosol-generating article 10 of Figure 2 does not include any capillary channels. Therefore, to allow the user's saliva to contact the biomarker sensor 22, the user may directly lick the biomarker sensor 22 or a portion of the cigarette paper wrapper 18 containing the biomarker sensor 22 with the user's tongue.

[0107] Again, if the user's saliva contains nicotine or cocidine, a color change will be caused which can be visually determined by the user and may also be detected by a corresponding sensor arrangement in the aerosol generating device.

[0108] 3 illustrates an aerosol generating device 30 for use with the aerosol generating article 10. The aerosol generating article 30 and the aerosol generating device 10 together form an aerosol generating system.

[0109] 3A, the aerosol generating device 30 includes a housing 32 having a removable cap 34. The removable cap 34 includes a cover 36 that covers an opening in the removable cap 34. The aerosol generating device 30 includes a button 38 via which the aerosol generating device 30 may be turned on and off.

[0110] 3B illustrates the internal components of the aerosol generating device 30. The aerosol generating device 30 includes a battery 40, a charging port 42, and a printed circuit board 44 having a control unit 46.

[0111] The aerosol generating device defines a cavity 50 accessible through an opening in the removable cap 34. The cavity 50 contains an electric heater 52 and acts as a heating chamber for heating the sensory media portion of the aerosol generating article.

[0112] A sensor arrangement is provided within the cavity 50. The sensor arrangement includes an optical sensor 54. The optical sensor 54 is ring-shaped and extends around the inner surface of the cavity 50. The optical sensor 54 is located within direct line of sight of the biomarker sensor 22 of the inserted aerosol-generating article 10.

[0113] Figure 3C shows an aerosol-generating article 10 according to Figure 1 or 2 with a strip-shaped biomarker sensor 22. As can be seen from a comparison of Figures 3B and 3C, the vertical position of the biomarker sensor 22 corresponds to the vertical position of the optical sensor 54 when the aerosol-generating article 10 is fully inserted into the cavity of the aerosol-generating device 30.

[0114] The control unit of the aerosol generating device 30 is coupled to an optical sensor 54. The optical sensor 54 is configured to monitor the biomarker sensor 22. When the biomarker sensor 22 changes its color due to the presence of nicotine or cotinine in the user's saliva, the optical sensor 54 may generate a corresponding signal that is received by the control unit 46. Based on the data received from the optical sensor 54, the control unit 46 may adjust the operation of the aerosol generating device 30.

[0115] 4 shows a further embodiment of the aerosol-generating article 10 of the present invention. The aerosol-generating article 10 comprises a sensory media portion 12 and a mouthpiece portion 14 connected by a wrapper 18. Additional components 60, 62 are provided between the sensory media portion 12 and the mouthpiece portion 14. These additional components 60, 62 are hollow acetate tubes having different diameters, which are used to assist aerosol formation within the airflow path defined within the aerosol-generating article 10. A perforation line 58 containing a plurality of perforations is provided in an area of ​​the component 62, which is a hollow acetate tube of a larger diameter. A biomarker sensor 22 is provided upstream from the perforation line 58. The perforation line 58 is not covered by the user's mouth during the user experience, so that the biomarker sensor 22 located even further away from the mouth end 16 of the aerosol-generating article 10 does not directly contact the user's mouth during the user experience in the same way. To transfer the user's saliva to the biomarker sensor 22, the biomarker sensor 22 may be licked by the user in accordance with the embodiment described using FIG. 2, or a capillary tube may be provided in the aerosol-generating article 10 in accordance with the embodiment described using FIG. 1.

[0116] FIG. 5 also shows an embodiment of an aerosol-generating article 10 of the present invention, similar to the aerosol-generating article 10 of FIG. 4. In this embodiment, no perforation lines are provided. However, the part that may come into contact with the user's mouth is additionally wrapped with tipping paper 64 having a different color than the wrapper 18. The biomarker sensor 22 is provided upstream from the region covered by the tipping paper 64. Hence, again the biomarker sensor 22 is provided in an area of ​​the aerosol-generating article 10 that does not come into direct contact with the user's mouth during the user experience. To transport the user's saliva to the biomarker sensor 22, a capillary tube 20 is provided extending from the mouth end 16 of the aerosol-generating article 10 and operably connected to the biomarker sensor 22. For better visibility, only a portion of the capillary tube 20 is shown in FIG. 5 extending from the mouth end 16 of the aerosol-generating article 10. Typically, all the capillary tubes 20 will be configured to extend from the mouth end 16 of the aerosol-generating article 10.

Claims

1. An aerosol-generating article comprising an aerosol-forming substrate, wherein the aerosol-generating article comprises a mouth-side end and a distal end, and a biomarker sensor, wherein the biomarker sensor is provided to the aerosol-generating article and is at least 1 centimeter away from the mouth-side end. The aerosol-generating article.

2. The aerosol-generating article according to claim 1, further comprising a mouthpiece at the mouth-side end, and wherein the biomarker sensor is provided away from the mouthpiece.

3. The aerosol-generating article according to claim 1, further comprising a portion where the aerosol-forming substrate is provided, and wherein the biomarker sensor is positioned in the portion where the aerosol-forming substrate is provided.

4. The aerosol-generating article according to claim 1, further comprising a perforation, and wherein the biomarker sensor is provided upstream from the perforation.

5. The aerosol-generating article according to claim 1, wherein the aerosol-generating article has a cylindrical shape, and wherein the biomarker sensor is provided in the form of a band around the outer circumference of the aerosol-generating article.

6. The aerosol-generating article according to claim 1, wherein the biomarker sensor comprises a substance having a property that changes upon contact with a corresponding biomarker in the user's saliva.

7. The aerosol-generating article according to claim 1, wherein the substrate in the biomarker sensor is a colorimetric substance configured to change its color upon contact with nicotine or a nicotine metabolite present in the user's saliva.

8. The aerosol-generating article according to claim 1, wherein the biomarker sensor is positioned so as to be visually inspectable by the user.

9. The aerosol-generating article according to claim 1, wherein the biomarker sensor is positioned on the outer surface of the aerosol-generating article.

10. The aerosol-generating article according to claim 1, wherein the biomarker sensor is covered by one or more layers of a transparent, translucent, or perforated material.

11. The aerosol generating device according to any one of claims 1 to 10, comprising a cavity for receiving an aerosol generating article, and a sensor configured to detect a change in the characteristics of the biomarker sensor of the aerosol generating article.

12. The aerosol generating device according to claim 11, comprising an optical sensor configured to detect a colorimetric change of the biomarker sensor of the aerosol generating article.

13. An aerosol generating system comprising the aerosol generating article according to claim 1 and the aerosol generating device according to claim 11.

14. The aerosol generating system according to claim 13, wherein the aerosol generating device comprises a control unit operably coupled to the sensor and configured to control the operation of the aerosol generating device based on the biomarker concentration level obtained by the biomarker sensor of the aerosol generating article.

15. A method of operating the aerosol generating system according to claim 13, wherein the aerosol generating device comprises a control unit operably coupled to the sensor, and the operation of the aerosol generating device is controlled based on the biomarker concentration level obtained by the biomarker sensor of the aerosol generating article.

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