Pesticidal mixtures containing isoquinoline compounds

Abstract

A pesticidal mixture comprising as active compounds 1) at least one isoquinoline compound A of formula I: wherein R is CH2-pyrimidine-2 or cyclopropyl; and 2) ethiprole and fipronil; alpha-cypermethrin, bifenthrin, cyfluthrin, etofenprox, lambda-cyhalothrin, gamma-cyhalothrin, deltamethrin; thiamethoxam, imidacloprid, clothianidin, acetamiprid, thiacloprid, dinotefuran, nitenpyram, sulfoxaflor, flupyradifurone, triflumezopyrim; spinosad, spinetoram; abamectin, emamectin benzoate; pyriproxyfen; pymetrozine, afidopiropen; chlorfenapyr; teflubenzuron. ; buprofezin; methoxyfenozide; indoxacarb; spirotetramat, spiropydione, spidoxamat; chlorantraniliprole, cyantraniliprole, cyhalodiamide, cyclariniprole, flubendiamide, tetrachlorantraniliprole, tetraniliprole; flonicamid; brofuranilide; and at least one further compound B selected from dichloromesothiaz, dimpropyridaz, flupirimine, and oxazosulfil; methods and uses of these mixtures for controlling invertebrate pests such as insects, arachnids or nematodes in and on plants and for protecting plants and the like infested with pests, and in particular for protecting plant propagation material such as seeds. [Formula 1] TIFF2024531792000039.tif31170

Description

[Technical field]

[0001] The present invention relates to a pesticidal mixture comprising as active compounds at least one isoquinoline compound and at least one further pesticide.Furthermore, the present invention relates to a method for applying said mixture.

[0002] The present invention therefore relates to a pesticidal mixture comprising as active compounds: A) Formula I: [ka] [In the formula, R is CH2-pyrimidine-2 or cyclopropyl; B) 1) M.2 GABA-gated chloride channel antagonists: ethiprole and fipronil; 2) M.3 Pyrethroids: alpha-cypermethrin, bifenthrin, cyfluthrin, etofenprox, lambda-cyhalothrin, gamma-cyhalothrin, and deltamethrin; 3) nAChR agonists: thiamethoxam, imidacloprid, clothianidin, acetamiprid, thiacloprid, dinotefuran, nitenpyram, sulfoxaflor, flupyradifurone, and triflumezopyrim; 4) Spinosyns: spinosad and spinetoram; 5) M.6 Avermectins: abamectin and emamectin benzoate; 6) M.7 juvenile hormone analog pyriproxyfen; 7) M.9 Pymetrozine and afidopiropen; 8)M.13 Uncouplers of oxidative phosphorylation via disruption of the proton gradient: Chlorfenapyr; 9) M.15 Inhibitor of chitin biosynthesis type 0: Teflubenzuron; 10) M.16 Inhibitor of chitin biosynthesis type 1: buprofezin; 11)M.18 Ecdysone receptor agonist: methoxyfenozide; 12) M.22 Voltage-dependent sodium channel blockers: Indoxacarb; 13) M.23 Inhibitors of acetyl-CoA carboxylase: spirotetramat, spiropyridione, and spidoxamat; 14) M.28 Ryanodine receptor modulators: chlorantraniliprole, cyantraniliprole, cyhalodiamide, ciclariniprole, flubendiamide, tetrachlorantraniliprole, and tetraniliprole; 15) M.29: Chordotonal modulators: flonicamide; 16) M.30: Broflanilide; 17) M.UN. Mechanism of action unknown: dichloromesothiaz, dimpropyridaz, flupirimine, and oxazosulfil; and at least one further compound B selected from The pesticidal mixture comprises components A and B present in a weight ratio of 1000:1 to 1:1000.

[0003] One typical problem that arises in the field of pest control is the need to reduce the dosage rate of the active ingredient to reduce or avoid undesirable environmental or toxicological effects while still allowing effective pest control. Another problem that is encountered is the need to have available pest control agents that are effective against a broad spectrum of pests.

[0004] Another difficulty with the use of pesticides is that repeated, exclusive applications of individual pesticidal compounds often rapidly select for pests that have developed natural or adaptive resistance to the active compound in question. Thus, there is a need for pest control agents that help prevent or overcome resistance.

[0005] WO 2020 / 055955 describes isoxazoline compounds of formula I. These compounds are said to be useful for controlling invertebrate pests.

[0006] It is therefore an object of the present invention to provide pesticidal mixtures and / or compounds that solve at least one of the problems discussed, such as reducing the dosage rate, enhancing the activity spectrum, or combining knockdown activity with long-term control or resistance management.

[0007] It has now been found that at least one of these objects is achieved by the active compound combination defined at the beginning.

[0008] It has further been found that the simultaneous, i.e. joint or separate application of one or more active compounds A and one or more active compounds B, or the sequential application of one or more active compounds A and one or more active compounds B, can enhance the control of pests compared to the control rates possible with the individual compounds.

[0009] Furthermore, the present invention provides - a composition comprising a pesticidal mixture as defined herein and at least one inert liquid and / or solid acceptable carrier; - an agricultural composition comprising a pesticidal mixture as defined herein and at least one inert liquid and / or solid acceptable carrier; - a method for combating or controlling invertebrate pests, comprising contacting said pests or their food sources, habitats or breeding sites with a pesticidally effective amount of a pesticidal mixture as defined herein; - a method for protecting plants from attack or infestation by invertebrate pests, the method comprising contacting the plant, plant propagation material, or the soil or water in which the plant is growing, with a pesticidal effective amount of a pesticidal mixture as defined herein; - plant propagation material comprising a pesticidal mixture as defined herein in an amount ranging from 0.1 g to 10 kg per 100 kg of seeds; - a method for protecting plant propagation material, the method comprising contacting the plant propagation material with a pesticidal mixture as defined herein in an amount ranging from 0.1 g to 10 kg per 100 kg of plant propagation material; - the use of a pesticidal mixture as defined herein for protecting growing plants or plant propagation material from attack or infestation by invertebrate pests; - a method for controlling phytopathogenic harmful fungi, which comprises treating the fungi, their habitat or the plants, soil or seeds to be protected from fungal attack with an effective amount of a pesticidal mixture comprising at least one compound A as defined herein and at least one specific compound B as defined herein; - a method for protecting plants against phytopathogenic harmful fungi, comprising treating the fungi, their habitat or the plants, soil or seeds to be protected from fungal attack with an effective amount of a pesticidal mixture comprising at least one compound A as defined herein and at least one specific compound B as defined herein; - a method for protecting an animal from infestation and infection by a parasite, the method comprising administering to the animal an anti-parasitic amount of a pesticidal mixture as defined herein; - a method for treating animals infested and infected with parasites, comprising administering to the animal in need thereof a parasitic-effective amount of a pesticidal mixture as defined herein; and - the use of a pesticidal mixture as defined herein for combating parasites in and on animals; Regarding.

[0010] The mixture according to the invention may be a physical mixture of at least one compound A and at least one compound B. Thus, the invention also provides a mixture comprising at least one compound A and at least one compound B. However, the composition may also be any combination of at least one compound A and at least one compound B, and compounds A and B do not have to be present together in the same formulation.

[0011] An example of a composition according to the invention or a composition used according to the invention, in which at least one compound A and at least one compound B are not present together in the same formulation, is a combi-pack. In a combi-pack, the two or more components of the combi-pack are packaged separately, i.e., are not premixed together. As such, the combi-pack comprises one or more separate containers, such as vials, cans, bottles, pouches, bags, or canisters, each of which contains a separate component of the agrochemical composition. An example is a two-component combi-pack. Thus, the present invention also relates to a two-component combi-pack comprising, in sequence, a first component comprising at least one compound A, a liquid or solid carrier, and, if appropriate, at least one surfactant and / or at least one conventional auxiliary, and, in sequence, a second component comprising at least one compound B, a liquid or solid carrier, and, if appropriate, at least one surfactant and / or at least one conventional auxiliary. Further details, such as suitable liquid and solid carriers, surfactants, and conventional auxiliary agents, are described below.

[0012] The "combined" use of at least one compound A with at least one compound B can be understood, on the one hand, as the use of a physical mixture of at least one compound A and at least one compound B. On the other hand, the combined use may consist of the use of at least one compound A and at least one compound B separately, but within a sufficiently short time of each other so that the desired effect occurs. Further details of the combined use can be found in the specification below.

[0013] The term "invertebrate pests" (also called animal pests), as used herein, includes animal populations such as insects, arachnids and nematodes that attack plants and can thereby cause substantial damage to the attacked plants, as well as ectoparasites that parasitize animals, especially warm-blooded animals such as mammals or birds, or other higher animals such as reptiles, amphibians or fish, and can thereby cause substantial damage to the parasitized animal.

[0014] The term "compound according to the invention" or "compound of formula I" or "compound A" includes the compounds as defined herein, as well as their stereoisomers, salts, tautomers, or N-oxides. The term "compound of the invention" should be understood as equivalent to the term "compound according to the invention", and therefore includes its stereoisomers, salts, tautomers, or N-oxides.

[0015] The term "stereoisomer" encompasses both optical isomers, such as enantiomers and diastereomers (the latter existing due to the presence of one or more centers of chirality within a molecule) and geometric isomers (cis / trans isomers).

[0016] The compounds of the invention may be amorphous or may exist in one or more different crystalline states (polymorphs) which may have different macroscopic properties, such as stability, or may exhibit different biological properties, such as activity. The invention includes both amorphous and crystalline compounds of formula I, mixtures of the different crystalline states of each compound I, as well as amorphous or crystalline salts thereof.

[0017] Salts of compounds of formula I are preferably agriculturally and veterinarily acceptable salts, which can be formed in the usual manner, for example, if a compound of formula I has a basic functional group, by reacting the compound with an acid of said anion, or by reacting an acidic compound of formula I with a suitable base.

[0018] Suitable agriculturally acceptable salts are, in particular, salts of cations or acid addition salts of acids whose cations and anions, respectively, do not have any adverse effect on the action of the compounds according to the invention. Suitable cations are, in particular, ions of alkali metals (preferably lithium, sodium and potassium), ions of alkaline earth metals (preferably calcium, magnesium and barium) and ions of transition metals (preferably manganese, copper, zinc and iron), and also ions of ammonium (NH4 +) and substituted ammonium, in which one to four hydrogen atoms are replaced by C1-C4-alkyl, C1-C4-hydroxyalkyl, C1-C4-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, hydroxy-C1-C4-alkoxy-C1-C4-alkyl, phenyl, or benzyl. Examples of substituted ammonium ions include methylammonium, isopropylammonium, dimethylammonium, diisopropylammonium, trimethylammonium, tetramethylammonium, tetraethylammonium, tetrabutylammonium, 2-hydroxyethylammonium, 2-(2-hydroxyethoxy)ethylammonium, bis(2-hydroxyethyl)ammonium, benzyltrimethylammonium, and benzyl-triethylammonium, as well as phosphonium ions, sulfonium ions, preferably tri(C1-C4-alkyl)sulfonium, and sulfoxonium ions, preferably tri(C1-C4-alkyl)sulfoxonium.

[0019] The anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogen sulfate, sulfate, dihydrogen phosphate, hydrogen phosphate, phosphoric acid, nitric acid, hydrogen carbonate, carbonate, hexafluorosilicic acid, hexafluorophosphoric acid, benzoic acid, and anions of C1-C4-alkanoic acids, preferably formic acid, acetic acid, propionic acid, and butyric acid, which can be formed by reacting the compounds of formula I with an acid of the corresponding anion, preferably hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, or nitric acid.

[0020] The organic moieties mentioned in the definitions of the variables above, like the term halogen, are generic to a list of the individual members of that group. n ~C m represents in each case the possible number of carbon atoms in the group.

[0021] Further commercially available compounds B can be found in The Pesticide Manual, 18th Edition, British Crop Protection Council (2018) among other publications, and its online database https: / / www.bcpc.org / product / bcpc-online-pesticide-manual-latest-version.

[0022] It has been found that the simultaneous application of at least one compound I and at least one compound B, i.e. together or separately, or the sequential application of at least one compound of formula I and at least one compound B, allows for better control of animal pests than the individual compounds alone (synergistic mixtures).

[0023] The compounds of formula I can be used as synergists for certain insecticidal active compounds.By applying the compounds of formula I simultaneously with at least one active compound B, i.e. together or separately, the insecticidal activity increases superadditively.

[0024] The compounds of formula I can exist in different crystal modifications, whose biological activity may differ.

[0025] One embodiment of the present invention is characterized in that component A is a compound selected from the group consisting of compounds I-1 and I-2: (I-1): 5-[(5S)-5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-(pyrimidin-2-ylmethyl)isoquinoline-8-carboxamide, and (I-2): relates to a pesticidal mixture selected from N-cyclopropyl-5-[(5S)-5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]isoquinoline-8-carboxamide.

[0026] A preferred embodiment of the present invention relates to pesticidal mixtures in which component A is compound I-1.

[0027] A preferred embodiment of the present invention relates to a pesticidal mixture in which components A and B are present in a total weight ratio of 20:1 to 1:500, preferably 10:1 to 1:100, more preferably 10:1 to 1:50, more preferably 10:1 to 1:25, in particular 10:1 to 1:10.

[0028] A particular embodiment of the invention is any one of the pesticidal mixtures A, B, C, D, E, F, G, H, J, K, L, M, N, O, and P:

[0029] The pesticidal mixture A contains as an active ingredient: A1) at least one compound of formula I; A2) 1a) Ethiprole, and 1b) a GABA-gate chloride channel antagonist selected from fipronil; Including, Components A1) and A2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 50:1 to 1:50, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to a ratio of component A1 of 1:1 to excess; in another embodiment, a ratio of component A2 of 1:1 to excess.

[0030] A preferred embodiment is a mixture in which compound A2 is 1b, especially in a mixture ratio of 1:1 to 1:50.

[0031] Pesticidal mixture B contains as the active ingredient B1) at least one compound of formula I; B2) 2a) alpha-cypermethrin, 2b) bifenthrin, 2c) cyfluthrin, 2d) etofenprox, 2e) lambda-cyhalothrin; 2f) gamma-cyhalothrin, and 2g) deltamethrin; and Components B1) and B2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to a ratio of component B1 from 1:1 to excess; in another embodiment, a ratio of component B2 from 1:1 to excess.

[0032] Preferred mixtures B are the combinations listed in Table B.

[0033] [Table 1]

[0034] Particularly preferred embodiments are mixtures in which compound B2 is selected from 2a, 2b, 2e, 2f and 2g, in particular in a mixture ratio of 1:1 to 1:100.

[0035] Pesticidal mixture C contains as active ingredient C1) at least one compound of formula I; C2) 3a) thiamethoxam, 3b) imidacloprid, 3c) clothianidin, 3d) acetamiprid, 3e) thiacloprid, 3f) dinotefuran, 3g) Nitenpyram, 3h) sulfoxaflor, 3i) flupyradifurone, 3j) a nAChR agonist selected from triflumezopyrim, Components C1) and C2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 500:1 to 1:500, more preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component C1 in a ratio of 1:1 to excess; in another embodiment, component C2 in a ratio of 1:1 to excess.

[0036] Preferred mixtures C are the combinations listed in Table C.

[0037] [Table 2]

[0038] A particularly preferred embodiment is a mixture in which the compound C2 is selected from 3a, 3b, 3c, 3d, 3e, 3f and 3h, in particular in a mixture ratio of 10:1 to 1:500.

[0039] The pesticidal mixture D contains as active ingredients: D1) at least one compound of formula I; D2) 4a) Spinosad, and 4b) a spinosyn selected from spinetoram; Components D1) and D2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component D1 in a ratio of 1:1 to excess; in another embodiment, component D2 in a ratio of 1:1 to excess.

[0040] Mixture D is a combination listed in Table D.

[0041] [Table 3]

[0042] Mixture D is a particularly preferred embodiment of the invention, especially with a mixing ratio of 1:1 to 1:25.

[0043] Pesticidal mixture E contains as active ingredients: E1) at least one compound of formula I; E2) M.6 5a) abamectin, and 5b) avermectins selected from emamectin benzoate; Including, Components E1) and E2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component E1 in a ratio of 1:1 to excess; in another embodiment, component E2 in a ratio of 1:1 to excess.

[0044] Mixture E is the combination listed in Table E.

[0045] [Table 4]

[0046] Mixture E is a particularly preferred embodiment of the present invention.

[0047] The pesticidal mixture F contains as active ingredients: F1) at least one compound of formula I; F2) 6a) afidopiropen, and 6b) a compound selected from pyriproxyfen; Including, Components F1) and F2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component F1 in a ratio of 1:1 to excess; in another embodiment, component F2 in a ratio of 1:1 to excess.

[0048] Mixture F is the combination listed in Table F.

[0049] [Table 5]

[0050] A particularly preferred embodiment is the mixture in which compound F2 is 6a.

[0051] The pesticidal mixture G contains as active ingredients: G1) at least one compound of formula I; G2) Chlorfenapyr and Including, Components G1) and G2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to a ratio of 1:1 to excess of component G1; in another embodiment, a ratio of 1:1 to excess of component G2.

[0052] Mixture G is a preferred embodiment of the invention, especially with a mixing ratio of 1:1 to 1:10.

[0053] The pesticidal mixture H contains as active ingredients: H1) at least one compound of formula I; H2) Teflubenzuron, Including, Components H1) and H2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component H1 in a ratio of 1:1 to excess; in another embodiment, component H2 in a ratio of 1:1 to excess.

[0054] Mixture H is a preferred embodiment of the present invention.

[0055] The pesticidal mixture J contains as an active ingredient: J1) at least one compound of formula I; J2) Methoxyfenozide, Including, Components J1) and J2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component J1 in a ratio of 1:1 to excess; in another embodiment, component J2 in a ratio of 1:1 to excess.

[0056] Mixture J is a preferred embodiment of the invention, especially with a mixing ratio of 1:1 to 1:25.

[0057] The pesticidal mixture K contains as active ingredients: K1) at least one compound of formula I; K2) Indoxacarb, Including, Components K1) and K2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, in particular 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to a ratio of component K1 of 1:1 to excess; in another embodiment, a ratio of component K2 of 1:1 to excess.

[0058] Mixture K is a preferred embodiment of the invention, especially with a mixing ratio of 20:1 to 1:10.

[0059] The pesticidal mixture L contains as active ingredients: L1) at least one compound of formula I; L2) 13a) spirotetramat, 13b) spiropyridione, and 13c) an inhibitor of acetyl-CoA carboxylase selected from spidoxamat; Including, Components L1) and L2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component L1 in a ratio of 1:1 to excess; in another embodiment, component L2 in a ratio of 1:1 to excess.

[0060] Mixture L is a combination listed in Table L.

[0061] [Table 6]

[0062] Mixture L is a particularly preferred embodiment of the invention, especially in a mixing ratio of 1:1 to 1:400.

[0063] The pesticidal mixture M contains as active ingredients: M1) at least one compound of formula I; M2) 14a) flubendiamide, 14b) chlorantraniliprole, 14c) cyantraniliprole, 14d) Tetraniliprole, 14e) tetrachlorantraniliprole, 14f) Ciclariniprole, 14g) cyhalodiamide, and a ryanodine receptor modulator selected from Components M1) and M2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component M1 in a ratio of 1:1 to excess; in another embodiment, component M2 in a ratio of 1:1 to excess.

[0064] Preferred mixtures M are the combinations listed in Table M.

[0065] [Table 7]

[0066] A particularly preferred embodiment is a mixture in which compound C2 is selected from 14b and 14c, in particular in a mixing ratio of 1:1 to 1:50.

[0067] The pesticidal mixture N contains as an active ingredient: N1) at least one compound of formula I; N2) flonicamid and Including, Components N1) and N2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component N1 in a ratio of 1:1 to excess; in another embodiment, component N2 in a ratio of 1:1 to excess.

[0068] Mixture N is a preferred embodiment of the present invention.

[0069] The pesticidal mixture O contains as active ingredients: O1) at least one compound of formula I; O2) Broflanilide and Including, Components O1) and O2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 100:1 to 1:100, more preferably 25:1 to 1:25, especially 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to component O1 in a ratio of 1:1 to excess; in another embodiment, component O2 in a ratio of 1:1 to excess.

[0070] Mixture O is a preferred embodiment of the present invention, especially with a mixing ratio of 1:1 to 1:250.

[0071] The pesticidal mixture P contains as active ingredients: P1) at least one compound of formula I; P2) 17a) dichloromethazone, 17b) Gymnopropyrrhizal, 17c) Flupirimine, and 17d) A compound having an unknown mechanism of action selected from oxazosulfils; Including, Components P1) and P2) are present in a total weight ratio of 1000:1 to 1:1000, preferably 25:1 to 1:25, in particular 10:1 to 1:10. In the above mentioned ratios, one embodiment relates to a ratio of component P1 from 1:1 to excess; in another embodiment, a ratio of component P2 from 1:1 to excess.

[0072] Mixture P is a combination listed in Table P.

[0073] [Table 8]

[0074] A particularly preferred embodiment is a mixture in which compound P2 is selected from 17a and 17b, in particular in a mixing ratio of 5:1 to 1:2.

[0075] A binary mixture of a compound of formula I and compound B is a preferred embodiment of the present invention.

[0076] The present invention also relates to an agrochemical composition comprising an adjuvant and a mixture according to the invention.

[0077] The pesticide composition comprises a pesticidally effective amount of the mixture of the present invention.

[0078] Compound I can be converted into the usual types of pesticide compositions, such as solutions, emulsifiable concentrates, suspensions, dusts, powders, pastes, granules, compacts, capsules, and mixtures thereof. Examples of types of compositions are suspensions (e.g. SC, OD, FS), emulsifiable concentrates (e.g. EC), emulsifiable concentrates (e.g. EW, EO, ES, ME), capsules (e.g. CS, ZC), pastes, pastilles, wettable powders or dusts (e.g. WP, SP, WS, DP, DS), compacts (e.g. BR, TB, DT), granules (e.g. WG, SG, GR, FG, GG, MG), insecticidal articles (e.g. LN), and gel formulations (e.g. GF) for the treatment of plant propagation materials (e.g. seeds). These and further types of compositions are defined in “Catalogue of pesticide formulation types and international coding system”, Technical Monograph No. 2, 6th Ed. May 2008, CropLife International. The compositions are prepared by known methods, for example those described by Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001; or Knowles, New developments in crop protection product formulation, Agrow Reports DS243, T&F Informa, London, 2005.

[0079] Suitable auxiliaries are solvents, liquid carriers, solid carriers or fillers, surfactants, dispersants, emulsifiers, wetting agents, adjuvants, solubilizers, penetration enhancers, protective colloids, adhesives, thickeners, moisturizers, water repellents, attractants, feeding stimulants, compatibilizers, bactericides, antifreeze agents, antifoaming agents, colorants, tackifiers, and binders.

[0080] Suitable solvents and liquid carriers are water and organic solvents. Suitable solid carriers or fillers are mineral earths.

[0081] Suitable surfactants are surface active compounds such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes. Such surfactants can be used as emulsifiers, dispersants, solubilizers, wetting agents, penetration enhancers, protective colloids, or adjuvants. Surfactants are listed in McCutcheon's, Vol. 1: Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (International or North American Ed.). Suitable anionic surfactants are alkali, alkaline earth, or ammonium salts of sulfonates, sulfates, phosphates, and carboxylates. Suitable nonionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar surfactants, and polymeric surfactants. Suitable cationic surfactants are quaternary surfactants.

[0082] The agrochemical composition generally contains 0.01 to 95% by weight, preferably 0.1 to 90% by weight, most preferably 0.5 to 75% by weight of the active substance. The active substance is used at a purity of 90% to 100%, preferably 95% to 100%.

[0083] Various types of oils, wetting agents, adjuvants or fertilizers can be added to the active substances or to the compositions containing them as premixes or, if appropriate, can be added only immediately before use (tank mix). These agents can be mixed with the compositions according to the invention in a weight ratio of 1:100 to 100:1.

[0084] The user usually applies the composition according to the invention from a predosage device, a backpack sprayer, a spray tank, a spray aircraft or an irrigation system. Usually, the agrochemical composition is made up to the desired application concentration with water, buffers and / or further auxiliaries, thus obtaining a ready-to-use spray solution or agrochemical composition according to the invention. Usually, 20 to 2000 liters of ready-to-use spray solution are applied per hectare of agriculturally useful area.

[0085] The mixtures of the present invention are suitable for use in protecting crops, plants, plant propagation materials, such as seeds, or the soil or water in which the plants are growing, from attack or infestation by animal pests.The present invention therefore also relates to a method for protecting plants, which comprises contacting the crops, plants, plant propagation materials (such as seeds), or the soil or water in which the plants are growing, to be protected from attack or infestation by animal pests, with a pesticidal amount of the mixtures of the present invention.

[0086] The mixture of the present invention is also suitable for use in eliminating or controlling animal pests.Therefore, the present invention also relates to a method for eliminating or controlling animal pests, which comprises contacting animal pests, their habitats, breeding grounds or feeding sources, or crops, plants, plant propagation materials (e.g. seeds), or soils, or areas, materials or environments in which animal pests grow or can grow, with a pesticidally effective amount of the mixture of the present invention.

[0087] The mixtures of the present invention are effective against any and all developmental stages, including eggs, larvae, pupae, and adults, both through contact and ingestion.

[0088] The mixtures according to the invention can be applied on their own or in the form of compositions which contain them.

[0089] Application can be carried out both before and after infestation of the crops, plants or plant propagation materials by pests.

[0090] The term "contacting" includes both direct contact (applying a compound / composition directly onto an animal pest or plant) and indirect contact (applying a compound / composition to a locus).

[0091] The term "animal pests" includes arthropods, gastropods and nematodes. Preferred animal pests according to the invention are arthropods, preferably insects and arachnids, especially insects.

[0092] The term "plants" includes but is not limited to cereals such as durum and other wheat, rye, barley, triticale, oats, rice, or corn (fodder and sugar / sweet corn and field corn); beets, such as sugar beet or fodder beet; fruits, such as pome fruits, stone fruits, or soft fruits, such as apple, pear, plum, peach, nectarine, almond, cherry, papaya, strawberry, raspberry, blackberry, or gooseberry; legumes, such as beans, lentils, peas, alfalfa, or soybeans; oil plants, such as rapeseed (oilseed rape), turnip, or other oilseeds. rape), mustard, olive, sunflower, coconut, cocoa bean, castor bean, oil palm, groundnut, or soybean; cucurbits, such as squash, pumpkin, cucumber, or melon; fibre plants, such as cotton, flax, hemp, or jute; citrus fruits, such as orange, lemon, grapefruit, or mandarin; vegetables, such as eggplant, spinach, lettuce (e.g. iceberg lettuce), chicory, cabbage, asparagus, cabbage, carrot, onion, These include garlic, leek, tomato, potato, cucurbits, or sweet pepper; lauraceae, such as avocado, cinnamon, or camphor; energy plants and source plants, such as corn, soybean, rapeseed, sugarcane, or oil palm; tobacco; nuts, such as walnuts; pistachios; coffee; tea; bananas; vines; hops; sweetleaf (stevia); rubber plants, or ornamental and forest plants, shrubs, broadleaf or evergreen trees, eucalyptus; turf; lawn; grasses. Preferred plants include potato, sugar beet, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybean, rapeseed, legumes, sunflower, coffee, or sugarcane; fruits; vines; ornamental plants; or vegetables, such as cucumber, tomato, bean, or squash.

[0093] The term "seed" encompasses seeds and plant propagation bodies (including true seeds, seed pieces, suckers, corms, bulbs, fruits, tubers, grains, cuttings and cut shoots), preferably meaning true seeds.

[0094] "Pesticidal effective amount" means the amount of active ingredient required to obtain an observable effect on growth, including the effect of necrosis, killing, hindering, preventing, and removing, destroying, or otherwise gradually reducing the appearance and activity of the target organism. Pesticidal effective amount may vary for various compounds / compositions used in the present invention. Pesticidal effective amount of the composition also varies according to the prevailing conditions (e.g., desired pesticidal effect and duration, weather, target species, location, mode of application).

[0095] When used in treating crop plants (e.g. by foliar application), the rate of application of the active ingredient of the invention may range from 0.0001 g to 4000 g per hectare, for example from 1 g to 2 kg per hectare, or from 1 g to 750 g per hectare, desirably from 1 g to 100 g per hectare.

[0096] The mixtures of the present invention are also suitable for use against non-crop insect pests.For use against said non-crop pests, compound I can be used as bait compositions, gels, general insect sprays, aerosols, ultra-low-volume applications and mosquito nets (impregnation or surface application).

[0097] The term "non-crop insect pest" refers to pests that are particularly associated with non-crop targets, such as ants, termites, wasps, flies, ticks, mosquitoes, bedbugs, crickets, or cockroaches, such as Aedes aegypti, Musca domestica, Tribolium spp.; termites, such as Reticulitermes flavipes, Coptotermes formosanus; cockroaches, such as Blatella germanica, Periplaneta Americana; ants, such as Solenopsis invicta, Linepithema humile, and Camponotus pennsylvanicus.

[0098] The bait can be a liquid, solid, or semi-solid preparation (e.g., a gel).When used in a bait composition, the typical content of the active ingredient is 0.001% to 15% by weight of the active compound, preferably 0.001% to 5% by weight.

[0099] The mixtures and compositions thereof of the present invention can be used to protect wood materials, such as trees, wooden fences, sleepers, picture frames, artwork, and the like, as well as buildings, building materials, furniture, leather, textiles, vinyl products, electrical wires and cables, from ants, termites, and / or wood- or textile-destroying beetles, and to control ants and termites from harming crops or humans (e.g., when pests invade homes and public facilities or nest in gardens, orchards, or parks).

[0100] Customary application rates for protecting materials are, for example, 1 m of treated material. 2 per unit area, the amount of active compound is 0.001 g to 2000 g, or 0.01 g to 1000 g, preferably 1 m 2 Each serving weighs 0.1g to 50g.

[0101] Insecticidal compositions for use in impregnating materials typically contain from 0.001 to 95% by weight, preferably from 0.1 to 45% by weight, more preferably from 1 to 25% by weight of at least one repellent and / or insecticide.

[0102] The mixtures of the present invention are particularly suitable for effectively controlling animal pests, such as arthropods and nematodes, including: Insects of the suborder Auchenorrhyncha, e.g. Amrasca biguttula, Empoasca spp., Nephotettix virescens, Sogatella furcifera, Mahanarva spp., Laodelphax striatellus, Mahanarva fimbriolata, Nilaparvata lugens, Diaphorina citri; Lepidoptera, e.g. Diatraea saccharalis, Helicoverpa spp., Heliothis virescens, Lobesia botrana, Manduca sexta, Ostrinia nubilalis, Plutella xylostella, Pseudoplusia includens, Scirpophaga incertulas, Sesamia spp., Spodoptera spp., Trichoplusia ni, Tuta absoluta, Cnaphalocrocis medialis, Cydia pomonella, Chilo suppressalis, Anticarsia gemmatalis, Agrotis ipsilon, Chrysodeixis includens; Hemipteran insects, such as Lygus spp., stink bugs, such as Euschistus spp., Halyomorpha halys, Nezara viridula, Piezodorus guildinii, Dichelops furcatus; Thrips, e.g. Frankliniella spp., Thrips spp., Dichromothrips corbettii; Aphids, for example Acyrthosiphon pisum, Aphis spp., Myzus persicae, Macrosiphum euphorbiae, Rhopalosiphum spp., Schizaphis graminum, Megoura viciae; Whiteflies, e.g. Trialeurodes vaporariorum, Bemisia spp.; Coleoptera, such as Atomaria linearia, Phyllotreta spp., Melanotus spp., Meligethes aeneus, Leptinotarsa ​​decimlineata, Ceutorhynchus spp., Diabrotica spp., Anthonomus grandis, Atomaria linearia, Agriotes spp., Epilachna spp.; Hypothenemus hampei; Lissorhoptrus oryzophilus);Melanotus spp.;Otiorhynchus sulcatus;Oulema spp.;Phyllotreta spp.;Japanese beetle (Popillia japonica);Psylliodes chrysocephala; Flies, e.g. Delia spp., Ceratitis capitata, Bactrocera spp., Liriomyza spp.; Mayetiola destructor; Rhagoletis spp. Scale insects (Coccoidea), e.g. Aonidiella aurantia, Ferrisia virgate; Coccus spp.; Quadraspidiotus perniciosus Arachnida anthropods (mites), for example Penthaleus major, Panonychus spp.; Tetranychus spp.; Nematodes, for example Heterodera glycines, Meloidogyne spp., Pratylenchus spp., Caenorhabditis elegans.

[0103] The mixtures of the present invention are suitable for use in treating or protecting animals against parasitic infestation or infection.Accordingly, the present invention also relates to the use of the compounds of the present invention for the manufacture of a medicament for treating or protecting animals against parasitic infestation or infection.Furthermore, the present invention relates to a method for treating or protecting animals against parasitic infestation and infection, which comprises administering or applying to the animal a parasiticidally effective amount of compound I orally, topically or parenterally.

[0104] The present invention also relates to the non-therapeutic use of the compounds of the present invention for treating or protecting animals against parasitic infestation and infection.Furthermore, the present invention relates to a non-therapeutic method of treating or protecting animals against parasitic infestation or infection, which comprises applying to the locus a parasiticidally effective amount of the mixtures of the present invention.

[0105] The mixtures of the present invention are further suitable for use in combating or controlling parasites in and on animals.The present invention further relates to a method of combating or controlling parasites in and on animals, comprising contacting the parasites with a parasitic-effective amount of the mixtures of the present invention.

[0106] The present invention also relates to the non-therapeutic use of the mixtures of the present invention for controlling or eradicating parasites.Furthermore, the present invention relates to a non-therapeutic method for eradicating or controlling parasites, which comprises applying to a locus a parasiticidally effective amount of the mixtures of the present invention.

[0107] The mixtures of the present invention can be effective both through contact (through soil, glass, walls, mosquito nets, carpets, blankets, or animal parts) and ingestion (e.g., bait).Furthermore, compound I can be applied to any and all developmental stages.

[0108] The mixtures according to the invention can be applied on their own or in the form of compositions which contain them.

[0109] The term "habitat" refers to a habitat, food source, breeding ground, area, material, or environment outside an animal in which a parasite lives or can live.

[0110] As used herein, the term "parasites" includes endoparasites and ectoparasites. In some embodiments of the invention, endoparasites may be preferred. In other embodiments, ectoparasites may be preferred. Infestations of warm-blooded animals and fish include lice, bite lice, ticks, nasal bots, pediculid flies, stable flies, muscoid flies, flies, myiasitic fly larvae, chiggers, black flies, mosquitoes, and fleas.

[0111] The mixtures of the present invention are particularly useful for controlling the following parasites: bedbugs (Cimex lectularius), brown dog ticks (Rhipicephalus sanguineus), and cat fleas (Ctenocephalides felis).

[0112] As used herein, the term "animal" includes warm-blooded animals (including humans) and fish. Preferred are mammals, such as cattle, sheep, swine, camels, deer, horses, pigs, poultry, rabbits, goats, dogs, and cats, buffalo, donkeys, fallow deer, and reindeer, as well as fur animals, such as minks, chinchillas, and raccoons, birds, such as hens, geese, turkeys, and ducks, and fish, such as freshwater and saltwater fish, such as trout, carp, and eels. Particularly preferred are domestic animals, such as dogs or cats.

[0113] The mixture of the present invention may be applied in a total amount of 0.5 mg / kg to 100 mg / kg per day, preferably 1 mg / kg to 50 mg / kg per day.

[0114] For oral administration to warm-blooded animals, Compound I may be formulated as animal feed, animal feed premix, animal feed concentrate, pill, liquid, paste, suspension, drench, gel, tablet, bolus, and capsule. For oral administration, the selected dosage form should provide the animal with 0.01 mg to 100 mg of the mixture of the present invention per kg of animal body weight per day, preferably 0.5 mg to 100 mg per kg of animal body weight per day.

[0115] Alternatively, the mixture of the present invention may be administered parenterally (e.g., by intraruminal, intramuscular, intravenous, or subcutaneous injection) to animals. Compound I may be dispersed or dissolved in a physiologically acceptable carrier for subcutaneous injection. Alternatively, the mixture of the present invention may be formulated into an implant for subcutaneous administration. In addition, the mixture of the present invention may be administered transdermally to animals. For parenteral administration, the selected dosage form should provide the animal with 0.01 mg / kg to 100 mg / kg of the mixture of the present invention per kg of animal body weight per day.

[0116] The mixture of the present invention can also be applied topically to animals in the form of dips, powders, dusts, collars, medallions, sprays, shampoos, spot-on formulations and pour-on formulations, as well as ointments or oil-in-water or water-in-oil emulsions.For topical application, dips and sprays usually contain 0.5 ppm to 5,000 ppm, preferably 1 ppm to 3,000 ppm of compound I.In addition, the mixture of the present invention can be formulated as an ear tag for animals, especially quadrupeds (e.g., cattle and sheep).

[0117] Oral solutions are administered directly.

[0118] Solutions for application to the skin may be dripped, spread, rubbed, sprinkled or sprayed.

[0119] The gel is applied or spread onto the skin or introduced into a body cavity.

[0120] Pour-on formulations are applied or sprayed onto limited areas of the skin, allowing the active compound to penetrate the skin and act systemically. Pour-on formulations are prepared by dissolving, suspending or emulsifying the active compound in a suitable skin-compatible solvent or solvent mixture.

[0121] The emulsion may be administered orally, transdermally, or as an injection.

[0122] Suspensions may be administered orally or topically / dermally.

[0123] Semisolid preparations may be administered orally or topically / dermally.

[0124] For the production of solid preparations, the active compound is mixed with suitable excipients and, if appropriate with the addition of auxiliaries, brought into the desired form.

[0125] The compositions that can be used in the present invention can generally contain about 0.001 to 95% of the mixture.

[0126] The ready-to-use preparations contain the compound acting against parasites, preferably ectoparasites, in a concentration of 10 ppm to 80% by weight, preferably 0.1 to 65% by weight, more preferably 1 to 50% by weight, most preferably 5 to 40% by weight.

[0127] Preparations which are diluted before use contain the compound acting against ectoparasites in a concentration of 0.5 to 90% by weight, preferably 1 to 50% by weight.

[0128] Furthermore, the preparation comprises a compound of the formula I acting against endoparasites in a concentration of 10 ppm to 2% by weight, preferably 0.05 to 0.9% by weight, very particularly preferably 0.005 to 0.25% by weight.

[0129] The solid formulations releasing the compounds of the invention may be applied in a total amount of 10 mg to 300 mg, preferably 20 mg to 200 mg, most preferably 25 mg to 160 mg per kg of body weight of the animal to be treated, for a period of 3 weeks. EXAMPLES

[0130] Biological Examples of the Invention The present invention will now be described in more detail with reference to the following examples. Synergy can be described as an interaction where the combined effect of two or more compounds is greater than the sum of the individual effects of each compound. The Colby formula can be used to calculate the presence of synergy in terms of control rate between two mixing partners (X and Y) (Colby, SR, 1967, Calculating Synergistic and Antagonistic Responses in Herbicide Combinations, Weeds, 15, 20-22):

number

[0131] If the observed combination control effect is greater than the expected combination control effect (E), then the combination effect is synergistic.

[0132] The following tests demonstrate the effectiveness of the compounds, mixtures or compositions of the present invention against certain pests.However, the pest control protection that the compounds, mixtures or compositions provide is not limited to these species.In certain cases, the combination of the compounds of the present invention with other invertebrate pest control compounds or agents is found to show synergistic effects against certain important invertebrate pests.

[0133] Analysis of synergy or antagonism between mixtures or compositions was determined using Colby's formula.

[0134] Test 1 To evaluate control of Tobacco budworm (Heliothis virescens), test units consisted of 96-well microtiter plates containing insect bait and 15-25 H. virescens eggs.

[0135] Compounds or mixtures were formulated using a solution containing 75% water and 25% DMSO. Various concentrations of formulated compounds were sprayed in duplicate, 10 μL, onto the insect diet using a custom-made microatomizer.

[0136] For the experimental mixtures in this study, equal volumes of both mixing partners at the respective desired concentrations were mixed together.

[0137] After application, the microtiter plates were incubated for 5 days at about 28±1° C. and about 80±5% relative humidity. Egg and larval mortality were then assessed visually. The results are listed in Tables 1.1 to 1.7 for the mixtures tested, where * indicates synergistic control effect according to Colby's formula.

[0138] [Table 9]

[0139] [Table 10]

[0140] [Table 11]

[0141] [Table 12]

[0142] [Table 13]

[0143] [Table 14]

[0144] [Table 15]

[0145] Test 2 To evaluate control of yellow fever mosquitoes (Aedes aegypti), test units consisted of 96-well microtiter plates containing 200 μl of tap water and 5-15 newly hatched A. aegypti larvae per well.

[0146] Compounds or mixtures were formulated using a solution containing 75% water and 25% DMSO. Various concentrations of formulated compounds or mixtures were sprayed in duplicate, at 2.5 μL, onto the insect diet using a custom-made microatomizer.

[0147] For the experimental mixtures in this study, identical volumes of both mixing partners at the desired concentrations were mixed together.

[0148] After application, the microtiter plates were incubated at 28±1°C and 80±5% RH for 2 days. Larval mortality was then visually assessed. The results are listed in Tables 2.1 to 2.11 for the mixtures tested, where * indicates synergistic control effect according to Colby's formula.

[0149] [Table 16]

[0150] [Table 17]

[0151] [Table 18]

[0152] [Table 19]

[0153] [Table 20]

[0154] [Table 21]

[0155] [Table 22]

[0156] [Table 23]

[0157] [Table 24]

[0158] [Table 25]

[0159] [Table 26]

[0160] Test 3 To evaluate control of the peach aphid (Myzus persicae) through systemic means, the test unit consisted of a 96-well microtiter plate containing a liquid artificial bait under an artificial membrane.

[0161] Compounds or mixtures were formulated using a solution containing 75% water and 25% DMSO. Various concentrations of formulated compounds or mixtures were transferred into the aphid diet in duplicate using a custom-made pipettor.

[0162] For the experimental mixtures in this study, identical volumes of both mixing partners at the desired concentrations were mixed together.

[0163] After application, 5-8 adult aphids were placed on the artificial membrane in the microtiter plate wells. The aphids were then allowed to feed on the treated aphid bait and incubated at 23±1°C and 50±5% RH for 3 days. Aphid mortality and reproduction were then visually assessed. For the mixtures tested, the results are listed in Tables 3.1-3.3, where * indicates synergistic control effect according to Colby's formula.

[0164] [Table 27]

[0165] [Table 28]

[0166] [Table 29]

[0167] Test 4 To evaluate control of boll weevils (Anthonomus grandis), the test units consisted of 24-well microtiter plates containing insect bait and 20-30 A. grandis eggs.

[0168] Compounds or mixtures were formulated using a solution containing 75% water and 25% DMSO. Various concentrations of formulated compounds or mixtures were sprayed in duplicate onto the insect diet at 20 μL using a custom-made microatomizer.

[0169] For the experimental mixtures in this study, identical volumes of both mixing partners at the desired concentrations were mixed together.

[0170] After application, the microtiter plates were incubated at 23±1° C. and 50±5% RH for 5 days. Egg and larval mortality were then visually assessed. The results are listed in Tables 4.1 to 4.4 for the mixtures tested, where * indicates synergistic control effect according to Colby's formula.

[0171] [Table 30]

[0172] [Table 31]

[0173] [Table 32]

[0174] [Table 33]

[0175] Test 5 To evaluate control of Tobacco budworm (Plutella xylostella), test units consisted of 96-well microtiter plates containing insect bait and 15-25 P. xylostella eggs.

[0176] Compounds or mixtures were formulated using a solution containing 75% water and 25% DMSO. Various concentrations of formulated compounds were sprayed in duplicate onto the insect diet at 5 μL using a custom-made microatomizer.

[0177] For the experimental mixtures in this study, identical volumes of both mixing partners at the desired concentrations were mixed together.

[0178] After application, the microtiter plates were incubated at 28±1° C. and 80±5% RH for 5 days. Egg and larval mortality were then visually assessed. The results are listed in Table 5 for the mixtures tested.

[0179] [Table 34]

Claims

1. A pesticidal mixture comprising, as active ingredients: 1) Formula I: 【Chemical 1】 [In the formula, R is CH ２ -pyrimidine-2 or cyclopropyl; B) 1) M.2 GABA-gated chloride channel antagonists: ethiprole and fipronil; 2) M.3 Pyrethroids: alpha-cypermethrin, bifenthrin, cyfluthrin, etofenprox, lambda-cyhalothrin, gamma-cyhalothrin, and deltamethrin; 3) nAChR agonists: thiamethoxam, imidacloprid, clothianidin, acetamiprid, thiacloprid, dinotefuran, nitenpyram, sulfoxaflor, flupyradifurone, and triflumezopyrim; 4) Spinosyns: spinosad and spinetoram; 5) M. 6 Avermectins: abamectin and emamectin benzoate; 6) M.7 juvenile hormone analog pyriproxyfen; 7) M.9 Pymetrozine and Afidopiropen; 8) M. 13 Uncoupler of oxidative phosphorylation through disruption of the proton gradient: chlorfenapyr; 9) M. 15 chitin biosynthesis type 0 inhibitor: teflubenzuron; 10) M. 16 chitin biosynthesis type 1 inhibitor: buprofezin; 11) M. 18 Ecdysone receptor agonist: methoxyfenozide; 12) M. 22 Voltage-gated sodium channel blocker: indoxacarb; 13) M. 23 Inhibitors of acetyl-CoA carboxylase: spirotetramat, spiropydione, and spidoxamat; 14) M.28 ryanodine receptor modulators: chlorantraniliprole, cyantraniliprole, cyhalodiamide, cyclariniprole, flubendiamide, tetrachlorantraniliprole, and tetraniliprole; 15) M. 29: Chordotonal organ modulator: flonicamide; 16) M. 30: Broflanilide; 17) M. UN. Mechanism of action unknown: dichloromezothiaz, dimpropyridaz, flupirimine, and oxazosulfil; and at least one further compound B selected from A pesticidal mixture in which component A and component B are present in a weight ratio of from 1000:1 to 1:1000.

2. Compound A is compound I-1: (I-1): The mixture according to claim 1, which is 5-[(5S)-5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-(pyrimidin-2-ylmethyl)isoquinoline-8-carboxamide.

3. 2. The mixture of claim 1, comprising one compound A and one compound B.

4. 2. The mixture of claim 1, wherein component 2) is selected from alpha-cypermethrin, bifenthrin, cyfluthrin, etofenprox, lambda-cyhalothrin, gamma-cyhalothrin, and deltamethrin.

5. 2. The mixture of claim 1, wherein component 2) is selected from alpha-cypermethrin, bifenthrin, cyfluthrin, and lambda-cyhalothrin.

6. 2. The mixture of claim 1, wherein component 2) is selected from the compounds thiamethoxam, imidacloprid, clothianidin, acetamiprid, thiacloprid, dinotefuran, sulfoxaflor, flupyradifurone, and triflumezopyrim.

7. 2. The mixture of claim 1, wherein component 2) is selected from the compounds thiamethoxam, imidacloprid, clothianidin, acetamiprid, thiacloprid, and triflumezopyrim.

8. 2. The mixture of claim 1, wherein component 2) is selected from the compounds spinosad and spinetoram.

9. 2. The mixture of claim 1, wherein component 2) is spinetoram.

10. 2. The mixture of claim 1, wherein component 2) is selected from the compounds flubendiamide, chlorantraniliprole, cyantraniliprole, and tetraniliprole.

11. 2. The mixture of claim 1, wherein component 2) is selected from the compounds chlorantraniliprole and cyantraniliprole.

12. 2. The mixture of claim 1, wherein component 2) is selected from the compounds fipronil, spinetoram, chlorfenapyr, teflubenzuron, methoxyfenozide, indoxacarb, spirotetramat, broflanilide, and dimpropyridaz.

13. 2. The mixture of claim 1, comprising compound A and active compound B in a weight ratio of 25:1 to 1:

25.

14. A composition comprising a pesticidal mixture according to any one of claims 1 to 13 and at least one inert liquid and / or solid carrier.

15. 14. An agricultural composition for combating animal pests, comprising a pesticidal mixture according to any one of claims 1 to 13, at least one inert liquid and / or solid acceptable carrier, and optionally at least one surfactant.

16. A method for combating or controlling invertebrate pests, comprising contacting the pests or their food sources, habitats or breeding sites with a pesticidally effective amount of the pesticidal mixture of any one of claims 1 to 13.

17. A method for protecting growing plants or plant propagation material from attack or infestation by invertebrate pests, comprising contacting the plants, plant propagation material, or the soil or water in which the plants are growing, with a pesticidally effective amount of the pesticidal mixture of any one of claims 1 to 13.

18. Use of a pesticidal mixture according to any one of claims 1 to 13 for protecting growing plants or plant propagation material from attack or infestation by invertebrate pests.

19. Use of a pesticidal mixture according to any one of claims 1 to 13 for combating parasites in and on animals.

Images