Method for producing skin disease-improving agent

Abstract

To provide a method for producing a skin disease-improving agent that is safe and can be used for a long period of time.SOLUTION: The present invention provides a method for producing a skin disease-improving agent used to alleviate one or more symptoms selected from the group consisting of atopic dermatitis, dullness and dry skin, which contains as an active ingredient Alpinia zerumbet cell sap obtained by reducing the pressure on Alpinia zerumbet in a vacuum extraction device and isolating and collecting the vacuum extract, Alpinia zerumbet cell sap.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to a method for producing an agent for improving skin diseases such as atopic dermatitis, dullness, and dry skin, using shell ginger. [Background technology]

[0002] Shell ginger is a plant of the Zingiberaceae family that grows in colonies in subtropical regions, including Okinawa Prefecture. It grows to a height of 2 to 3 meters and has roots, stems, leaves, flowers, and fruits depending on its growth stage. The shell ginger used in this invention refers to the part above the root. Therefore, hereinafter, in this invention, including the wording of the claims, "shell ginger" refers to the part excluding the root, and therefore, unless otherwise specified, any one or more of the stem, leaf, flower, and fruit of shell ginger are abbreviated as "shell ginger" in this invention.

[0003] As a traditional Chinese medicine, shell ginger is said to have effects such as strengthening the stomach and regulating the intestines, increasing appetite, treating poisonous insect bites, and suppressing coughs.

[0004] Meanwhile, various agents for improving skin diseases such as atopic dermatitis, dull skin, and dry skin have been proposed.

[0005] In particular, agents for improving atopic skin diseases have been attracting attention along with agents for improving skin diseases such as eczema, hives, prurigo, burns, insect bites, heat rash, rashes, dull skin, etc. (Patent Documents 1 and 2 below). Steroid agents are particularly effective, but they are known to have serious side effects when used for a long period of time (see

[0004] of Patent Document 1 below and

[0003] of Patent Document 2 below). The present invention provides an agent for improving skin diseases that is safe and can be used without worry even for a long period of time by using natural plants as raw materials, and a method for producing the same. [Prior art documents] [Patent documents]

[0006] [Patent Document 1] JP 2017-197471 A [Patent Document 2] Patent No. 6590233 Summary of the Invention [Problem to be solved by the invention]

[0007] The present invention provides a method for producing a skin disease improving agent which is safe and can be used for a long period of time without worry by using natural plants as raw materials. [Means for solving the problem]

[0008] (1) The method for producing a skin disease improving agent of the present invention is a method for producing a skin disease improving agent used to alleviate one or more symptoms selected from the group consisting of atopic dermatitis, dullness and dry skin, which comprises reducing the pressure on shell ginger in a vacuum extraction device and separating and collecting the cell juice of shell ginger, which is a vacuum extract, and which contains the cell juice of shell ginger as an active ingredient, characterized in that the degree of vacuum in the vacuum extraction device is -90 kPa to -98 kPa in gauge pressure, and the temperature of vacuum extraction in the vacuum extraction device is 30 to 45°C, as the temperature inside a raw material container containing shell ginger, which is the raw material to be vacuum extracted.

[0009] (2) It is preferable to mix the cell juice of shell ginger, which is a vacuum extract produced by the method described in (1) above, with cell juice of Makomo, which is obtained by separately reducing the pressure of Makomo in a vacuum extraction device, setting the vacuum degree in the vacuum extraction device to -90 kPa to -98 kPa in gauge pressure, and setting the temperature of the vacuum extraction in the vacuum extraction device to 30 to 45°C, which is the temperature in the raw material container containing Makomo, which is the raw material to be vacuum extracted. This mixture can also be preferably used as a skin disease improving agent used to alleviate one or more symptoms selected from the group consisting of atopic dermatitis, dullness, and dry skin.

[0010] Makomo (Rhizome) is a plant of the Poaceae family, which can become infected with smut fungus and form enlarged stems of Makomo, and these parts are called Makomodake. Makomo as used in this invention refers to the leaves. Therefore, hereinafter, in this invention, "Makomo" including the wording of the claims means Makomo leaves, and therefore, unless otherwise specified, Makomo leaves will be abbreviated to "Makomo" in this invention. Therefore, "Makomo cell sap" means cell sap that is a vacuum extract collected by vacuum extraction from Makomo leaves.

[0011] (3) In the manufacturing method of the skin disease improving agent described in (2) above, the ratio of shell ginger cell juice to wild rice cell juice is preferably 100 parts by weight of shell ginger cell juice to 10 to 100 parts by weight of wild rice cell juice. Effect of the Invention

[0012] (1) The method for producing a skin disease improving agent of the present invention is a simple method of vacuum extraction of shell ginger, which contains shell ginger cell juice as an active ingredient, and the agent is easily obtained by vacuum extraction. Since no extraction solvent or drugs are used for the extraction, separation is not required and there is no risk of contamination with these drugs. Moreover, by using natural plants as raw materials, a skin disease improving agent that is safe and can be used without worry for long-term use can be provided. According to the method of the present invention, shell ginger cell juice can be collected as a vacuum extracted liquid, and the collected vacuum extracted liquid can be used as a skin disease improving agent as it is. Of course, in order to specify the formulation form, commonly used ingredients may be added as necessary to make the formulation into a cream or other appropriate formulation form as long as the original pharmacological effect is not damaged.

[0013] Furthermore, the cell fluid, which is the vacuum extract of shell ginger obtained by the method of the present invention, is not a thin liquid even in its original state, but rather a moist liquid with a slight viscosity, so it is convenient to use it as it is after being vacuum extracted, or to apply it to the affected area.

[0014] (2) Furthermore, as described in (2) above, the method for producing the skin disease improving agent of the present invention is preferable in that the cell fluid of Shell Ginger is obtained by reducing the pressure of Shell Ginger in a vacuum extraction device and separating and collecting the cell fluid of Shell Ginger, and the cell fluid of Makomo is obtained by reducing the pressure of Shell Ginger in a vacuum extraction device and separating and collecting the cell fluid of Makomo, thereby exerting the effect of improving skin diseases and the function of suppressing itching.

[0015] It is preferable to mix the shell ginger and the wild rice at the raw material stage before vacuum extraction and then vacuum extract them, but to vacuum extract them separately and mix the cell extracts obtained by each extraction in the required ratio for use. The reason is that the amount of cell fluid contained in each raw material and the amount extracted by vacuum extraction vary depending on the time and place of collection of each raw material, so it is difficult to adjust the mixing ratio at the raw material stage to the target mixing ratio of the shell ginger cell fluid and the wild rice cell fluid, so it is preferable to avoid mixing the shell ginger and the wild rice at the raw material stage and collect the cell fluid, and to carry out the extraction of the shell ginger cell fluid by vacuum extraction separately and the extraction of the wild rice cell fluid by vacuum extraction separately, so that the cell fluids collected can be mixed in the desired ratio as needed.

[0016] In the present invention, the leaves of Zizania japonica are used rather than the stems and other parts of the plant, such as Zizania makomodake, so the vacuum extract of Zizania japonica is formed from the cell fluid of Zizania makomodake leaves, which is preferable because it does not contain smut fungi contained in Zizania japonica.

[0017] Furthermore, in the manufacturing method of the skin disease improving agent of the present invention described in item (1) or (2) above, the temperature of the vacuum extraction in the vacuum extraction device is 30 to 45°C, which is the temperature inside the raw material container containing the raw material to be vacuum extracted, which is either Shell Ginger or Makomo, both when separating and collecting the cell juice of Shell Ginger and when separating and collecting the cell juice of Makomo, respectively, thereby making it possible to easily extract the active ingredients of the cell extracts of Shell Ginger and Makomo described in each of the above items without decomposing them, which is preferable.

[0018] If the extraction temperature is too high, the active ingredients in the cell extract tend to decompose, whereas if the extraction temperature is too low, the extraction efficiency tends to decrease, so the temperature range described above is preferable.

[0019] In addition, by using a preferred embodiment in which the degree of vacuum in the vacuum extraction apparatus is -90 kPa to -98 kPa in gauge pressure, the cell sap of the shell ginger and the cell sap of the wild rice described in the respective sections above can be separated into solid and liquid from the shell ginger and the wild rice and can be easily collected, which is preferable.

[0020] (3) Furthermore, as described in the above paragraph (3), when the cell juice of Shell Ginger is further mixed with the cell juice of Makomo, it is preferable that the ratio of Shell Ginger cell juice to Makomo cell juice is 100 parts by weight of Shell Ginger cell juice to 10 to 100 parts by weight of Makomo cell juice, since this provides the function of suppressing itching while preventing the proportion of Shell Ginger cell juice from becoming too low, thereby reducing the function of improving skin diseases. [Brief description of the drawings]

[0021] [Figure 1] 1 is a schematic diagram of a vacuum extraction device for collecting cell fluid of shell ginger or wild rice according to the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0022] The cell sap of shell ginger of the present invention can be extracted by evacuating shell ginger (above the roots, i.e., at least one of the stem, leaves, flowers, and fruits) at a relatively low temperature using a vacuum extractor or the like, and cooling the cell sap vapor (evaporated liquid) that is exhausted. It is preferable to use a relatively fresh shell ginger, since it may not be possible to extract cell sap from shell ginger that has dried out or withered.

[0023] The temperature during vacuum extraction is preferably a relatively low temperature of 30 to 45°C, more preferably 30 to 40°C, in the container containing the shell ginger raw material. There are no particular limitations on the degree of vacuum in the vacuum extraction device, but the gauge pressure is preferably -90kPa to -98kPa, more preferably -92kPa to -95kPa. Note that the gauge pressure is set such that atmospheric pressure is 0, and pressures lower than this are negative, and pressures higher than atmospheric pressure are positive.

[0024] It is preferable to use shell ginger as a raw material as fresh as possible. Although not particularly limited, when vacuum extraction is performed, the shell ginger used should be cut into small pieces in order to more efficiently extract the cell fluid.

[0025] The vacuum pump of the vacuum extractor is not particularly limited, but a water ejector pump is one of the suitable pumps.

[0026] The method of collecting the cell fluid is not particularly limited, but for example, as shown in Fig. 1, the shell ginger as the raw material is placed in a raw material container 1 that is decompressed by a vacuum pump 6, and a cooling section (condenser) 3 and a collection tank 11 that collects the shell ginger cell fluid condensed by the condenser are provided in the middle of the pipes 2, 5, 7, 8, etc. that connect the container 1 to the vacuum pump 6, i.e., between the pipes 2 and 5. When the shell ginger cell fluid has accumulated in the collection tank 11 to an appropriate amount, the communication between the pipes 7 and 8 is blocked by the three-way valve 9 between the pipes 7 and 8, the vacuum suction is stopped, the pipes 7 and 14 are connected, the inside of the collection tank 11 is made normal pressure, and the valve 13 below the collection tank 11 where the cell fluid has accumulated is opened to collect the cell fluid 12. An appropriate cooling medium is introduced into the cooling section (condenser) 3 from the pipe 4 and discharged from the pipe 4'. The cooling medium discharged from the pipe 4' is usually re-cooled in a cooling unit (not shown) and repeatedly supplied to the cooling section (condenser) 3 from the pipe 4. 10 is a pipe for exhaust. The cooling temperature of the cooling section 3 may be in a temperature range in which the steam of the object to be collected, such as the cell fluid of shell ginger, turns into droplets, and although it depends on the degree of vacuum, it is preferably in the range of, for example, 5°C to 25°C. The temperature inside the raw material container 1 is preferably 30 to 45°C, more preferably 30 to 40°C. If this temperature is made too high, there is a risk that the active ingredients of the cell extract will be decomposed. Also, if it is made too low, the efficiency of extract collection by vacuum extraction tends to decrease, so the above range is preferable.

[0027] If necessary, a cooling jacket (not shown) may be provided around recovery tank 11 for storing the cell fluid, and the recovery tank 11 may be cooled to, for example, about the same temperature range as that of the condenser 3 .

[0028] The skin disease improving agent of the present invention containing the cell juice of Shell Ginger as an active ingredient can further contain cell juice that is a vacuum extract of Zizania lattice, if necessary. When Zizania lattice cell juice is mixed, although there is no particular limitation, the ratio of Zizania lattice cell juice to 100 parts by weight of Shell Ginger cell juice is preferably 10 to 100 parts by weight.

[0029] By including the cell sap of Zizania lattice, it is possible to suppress itching, which is a common symptom of skin diseases, which is preferable. If the mixing ratio of the cell sap of Zizania lattice is too high, the cell sap of the shell ginger will be diluted, and the function of the cell sap of the shell ginger will not be fully exerted, so the ratio of the cell sap of Zizania lattice is preferably within the above range.

[0030] The vacuum extraction device and manufacturing conditions (temperature, pressure, equipment used) for the cell juice of Zizania lattice may be the same as those for the vacuum extraction of Shell Ginger described above. However, Shell Ginger and Zizania lattice can be mixed and vacuum extracted at the raw material stage before vacuum extraction, but since the amount of cell juice contained in each raw material and the amount extracted by vacuum extraction vary depending on the time and place of collection of each raw material, it is difficult to adjust the mixing ratio at the raw material stage to the target mixing ratio of Shell Ginger cell juice and Zizania lattice cell juice, so it is preferable to avoid mixing Shell Ginger and Zizania lattice at the raw material stage and extract the cell juice of the cell juice of Shell Ginger by vacuum extraction separately and extract the cell juice of each separately, and mix and use the cell juices extracted at the desired ratio as necessary.

[0031] Furthermore, if necessary, the cell juice of the shell ginger of the present invention, or the mixture of the cell juice of the shell ginger of the present invention and the cell juice of wild rice, may be mixed with a vacuum extract of at least one selected from eucalyptus, Solidago altissima, wood ear, Japanese cypress, and Mucuna pruriens (hereinafter referred to as the "third component") and a vacuum extract of mineral water.

[0032] The vacuum extract components of eucalyptus have the function of promoting the improvement of skin diseases, the vacuum extract components of Solidago altissima also have the function of promoting the improvement of skin diseases, the vacuum extract components of wood ear mushrooms have the function of brightening the skin color and improving wrinkles, the vacuum extract components of Japanese cypress have the function of absorbing ultraviolet rays, and the vacuum extract components of Mucuna bean have the function of improving blood circulation and contributing to the improvement of skin diseases, and skin disease improving agents having these functions can be easily manufactured and are preferable.

[0033] The amount of the third component used varies depending on the type, and is therefore difficult to define in general terms, and is not particularly limited; however, it is about 5 to 100 parts by weight of the third component per 100 parts by weight of shell ginger cell fluid.

[0034] To obtain a vacuum extract of the third component, the vacuum extraction equipment and processing conditions are the same as those used in the vacuum extraction processing of shell ginger, and the same vacuum extraction equipment as shown in Figure 1 can be used. The conditions for producing the third component are also the same as those used in the vacuum extraction processing of shell ginger, with the temperature inside the container when the raw materials are placed being 30 to 45°C, preferably 30 to 40°C, and the degree of vacuum in the vacuum extraction equipment is not particularly limited, but is -90 kPa to -98 kPa, more preferably -92 kPa to -95 kPa, in terms of gauge pressure.

[0035] When a third component is used, a vacuum extract of mineral water is also mixed to adjust the concentration, and the mixing ratio is about 5 to 100 parts by weight of the vacuum extract of mineral water per 100 parts by weight of the total weight excluding the vacuum extract of mineral water.

[0036] There is no particular limitation on the mineral water, and ordinary mineral water can be used. Naturally, mineral water is drinkable water in which mineral components are dissolved, such as mineral water made from well water, spring water, or underground water that meets safety standards set by the Food Sanitation Law, and mineral water in which mineral components are artificially dissolved in purified water. It is necessary to use mineral water that has been vacuum extracted once, and since mineral water that has not been vacuum extracted is not soluble in at least one vacuum extract (third component) selected from eucalyptus, solidago altissima, wood ear, Japanese cypress, and Mucuna pruriens, it is also necessary to vacuum extract the mineral water used. The equipment and processing conditions for the vacuum extraction process are the same as those for the vacuum extraction process of shell ginger, with the temperature inside the container when the raw material is placed being 30 to 45°C, preferably 30 to 40°C, and the degree of vacuum in the vacuum extraction device is not particularly limited, but is -90 kPa to -98 kPa, more preferably -92 kPa to -95 kPa in gauge pressure.

[0037] If necessary, glycerin or xanthan gum may be added as a moisturizing agent to the vacuum extraction solution of the present invention. By including such a moisturizing agent, the skin condition can be kept moist and in good condition, which is preferable.

[0038] In the case of glycerin, 10 parts by weight or less of glycerin is preferable for 100 parts by weight of shell ginger vacuum extract, and if it is too much, the oil components of the skin are removed and it is difficult to function as a moisturizing component. There is no particular lower limit, but 3 parts by weight or more of glycerin is preferable to function as a moisturizing component.

[0039] In the case of xanthan gum, the amount of xanthan gum is preferably 0.1 parts by weight or less per 100 parts by weight of shell ginger vacuum extract, and if the amount is too much, the liquid becomes hard and difficult to use. There is no particular lower limit, but 0.05 parts by weight or more of xanthan gum is preferred to exhibit the function as a moisturizing agent.

[0040] As described above, the skin disease improving agent of the present invention is not extracted with chemicals or solvents, but is harvested from the above-mentioned plants as raw materials, which is preferable because it does not contain unnecessary residual impurities such as solvents.

[0041] The vacuum-extracted liquid of the present invention is derived from natural products, unlike so-called chemically synthesized drugs, and therefore can be used safely without side effects even when used for a long period of time, and is also excellent in improving skin diseases as a skin disease improving agent derived from a natural product. It has also been confirmed that the skin disease improving agent of the present invention, when passed through a sterilizing filter capable of filtering out germs, for example a sterilizing filter with a pore size of 2 μm, and sterilized with ozone or, in some cases, ultraviolet light, does not spoil for a long period of time (six months or more) at room temperature and normal pressure when the skin disease improving agent of the present invention is placed in a container with a lid closed.

[0042] Furthermore, the skin disease improving agent of the present invention has good permeability into the skin when applied to the skin.

[0043] The skin disease improving agent of the present invention can be used to alleviate symptoms such as atopic dermatitis, dullness, dry skin, etc. In particular, it is revolutionary that the agent is derived from natural plants and is effective in treating atopic dermatitis without using steroid ingredients.

[0044] The formulation form is not particularly limited, but in the case of topical skin preparations, it is preferable to use the extracted liquid form as it is, as it is easily absorbed into the skin. The extracted liquid form may also be in the form of a spray, lotion, or emulsion, but it is particularly preferable to use a pump-type spray container containing the extracted liquid vacuum extract as a spray, which does not require application to the skin by first applying it to a finger or the like and then to the affected area, and does not require rubbing the skin.

[0045] The skin disease improving agent of the present invention has no side effects even when used in large amounts, so the amount applied can be adjusted appropriately according to the symptoms. There are no particular limitations, but it is recommended to apply it about twice a day (or once a day depending on the symptoms), for an area of ​​10 cm of skin per application. 2 The amount is about 1 to 6 g, preferably about 3 to 5 g, in terms of the amount of cell solution.

[0046] In the case of an external preparation for skin, it is more effective to wash the affected area before administering the skin disease improving agent of the present invention.

[0047] In addition, other drugs may be used in combination as appropriate, so long as the object of the present invention can be achieved and the function of the active ingredient is not inhibited. EXAMPLES

[0048] In order to facilitate understanding of the present invention, the present invention will be described in detail below with reference to examples, but the present invention is not limited to these examples in any way.

[0049] Example 1 Using the device shown in Figure 1, fresh shell ginger (leaves, stems, and fruit) cut to a length of about 2 cm was placed in a sealable container 1, and the temperature inside the container 1 was kept at 35°C, and a water ejector vacuum pump was used as the vacuum pump 6 to reduce the pressure to a maximum of -95 kPa. The container 1 was cooled to 10°C in the cooling section (condenser) 3 located in the pipes 2, 5 connecting the container 1 and the vacuum pump 6, and the cell fluid of the shell ginger that had accumulated in the recovery tank 11 was collected. The cell fluid obtained by vacuum extraction of wild rice produced in the same manner was mixed at a ratio of 50 parts by weight to 100 parts by weight of shell ginger cell fluid, and the resulting mixture of shell ginger cell fluid and wild rice cell fluid was placed in a pump-type spray container and used twice a day (morning and evening) to treat dull skin that had developed near the nasolabial folds of the face, with one dose applied to an affected area of ​​10 cm. 2 After spraying about 3g per day for one week, it was confirmed that the dullness of the affected area had become smaller and lighter. Even with just one week of use, it was confirmed that severe dullness had improved and the area of ​​dullness had become smaller.

[0050] Example 2 A patient with atopic dermatitis had 8 inflamed areas (eczema) on his arm. The patient was sprayed with a pump-type spray bottle containing the skin disease improving agent prepared in the same manner as in Example 1 twice a day (morning and evening), covering an area of ​​10 cm2. 2 The researchers applied the product at a rate of approximately 5g per area and observed the condition of the affected area after one week of spraying. As a result, it was found that the number of inflamed areas caused by atopic dermatitis was reduced to three points after just one week of use, and that inflammation of atopic dermatitis was relatively improved even after just one week of use.

[0051] Example 3 The cell fluid of the vacuum extract of shell ginger produced in Example 1 (cell fluid of the vacuum extract of shell ginger alone, without any cell fluid of the vacuum extract of wild rice) was applied to the arm of a patient with dry skin who had itchy, flaky skin. The cell fluid of the vacuum extract of shell ginger alone obtained by the method of the present invention was applied to the entire arm of the patient with dry skin twice a day (morning and evening), with one application covering an area of ​​10 cm2. 2After applying approximately 5g per skin area and observing the condition of the skin one week later, it was confirmed that the itching had been reduced, the dryness had almost completely disappeared, and the skin had become smooth. [Industrial Applicability]

[0052] The method of the present invention for producing a skin disease improving agent containing cell juice from shell ginger and other plants as an active ingredient is useful as a simple method for producing agents for improving skin diseases such as atopic dermatitis, dullness, and dry skin.These skin disease improving agents can be easily produced by the simple means of placing the agent in a vacuum extraction device and performing vacuum extraction.Since no extraction solvents or drugs are used for extraction, there is no need to separate these, and a production method is provided that eliminates the risk of contamination with these chemicals, and can be used in the pharmaceutical industry, etc. [Explanation of symbols]

[0053] 1 Raw material container 2, 5, 7, 8, 14 Piping 3 Cooling section (condenser) 4, 4´ Piping for cooling medium 6. Vacuum Pump 9 3-way valve 10 Exhaust piping 11 Collection tank for storing cell fluid 12 Cell fluid 13 Valve

Claims

1. A method for producing a skin disease improving agent used to alleviate one or more symptoms selected from the group consisting of atopic dermatitis, dullness and dry skin, which contains shell ginger cell fluid as an active ingredient, by reducing the pressure of shell ginger in a vacuum extraction device and separating and collecting the cell fluid of the shell ginger, wherein the degree of vacuum in the vacuum extraction device is -90 kPa to -98 kPa in terms of gauge pressure, and the temperature of the vacuum extraction in the vacuum extraction device is 30 to 45°C, as measured inside a raw material container containing the shell ginger, which is the raw material to be vacuum extracted.

2. A method for producing a skin disease improving agent used to alleviate one or more symptoms selected from the group consisting of atopic dermatitis, dullness and dry skin, characterized in that it comprises mixing the cell juice of shell ginger which is a vacuum extract produced by the method described in claim 1 with the cell juice of shell ginger which has been separated and collected by separately reducing the pressure of seaweed in a vacuum extraction device, the degree of vacuum in the vacuum extraction device being -90 kPa to -98 kPa in gauge pressure, and the temperature of the vacuum extraction in the vacuum extraction device being 30 to 45°C, which is the temperature inside a raw material container containing seaweed, the raw material to be vacuum extracted.

3. A method for producing a skin disease improving agent as described in claim 2, characterized in that the ratio of shell ginger cell juice to wild rice cell juice is 100 parts by weight of shell ginger cell juice to 10 to 100 parts by weight of wild rice cell juice.

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