Herbicide composition and weed control method

Abstract

To provide a herbicide composition having an excellent control effect on weeds and a weed control method.SOLUTION: A herbicide composition includes epyrifenacil and methoproxybicyclon, wherein the weight ratio of the epyrifenacil to the methoproxybicyclon is in the range of 1:1 to 1:10.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a herbicidal composition and a method for controlling weeds. [Background technology]

[0002] Currently, many herbicides are used for the purpose of weed control, and for example, epirifenacil and methoproxibicyclon are known (see Patent Documents 1 and 2). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] U.S. Patent No. 6,537,948 [Patent Document 2] International Publication No. 2015 / 197468 Summary of the Invention [Problem to be solved by the invention]

[0004] An object of the present invention is to provide a herbicidal composition and a weed control method having excellent weed control effects. [Means for solving the problem]

[0005] The present inventors have found that the combined use of epirifenacil and methoproxibicyclon exerts an excellent weed control effect. The present invention includes the following aspects.

[0006] [1] A herbicide composition comprising epirifenacil and methoproxibicyclon, wherein the weight ratio of epirifenacil to methoproxibicyclon is in the range of 1:1 to 1:10. [2] The herbicide composition according to [1], wherein the weight ratio of epirifenacil to methoproxibicyclon is approximately 1:5. [3] The herbicide composition according to [1], which contains at least one organic solvent. [4] A method for weed control comprising the step of applying epirifenacil and methoproxibicyclon, together or separately in any order, wherein the application rate of epirifenacil is in the range of 15 to 40 g / ha and the application rate of methoproxibicyclon is in the range of 40 to 150 g / ha. [5] The weed control method according to [4], which comprises applying epirifenacil and methoproxibicyclon to a crop field. [6] The weed control method according to [5], wherein the crop field is a soybean field. Effect of the Invention

[0007] The present invention makes it possible to control weeds with high effectiveness. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0008] The herbicidal composition of the present invention (hereinafter referred to as the composition of the present invention) contains epirifenacil and methoproxibicyclon.

[0009] Epirifenacil is a known compound and can be prepared by known methods, such as the method described in US Pat. No. 6,537,948.

[0010] Metoproxibicyclon (CAS Registry Number: 1848207-89-5) is a known compound represented by the following formula (I), and can be produced by known methods such as the method described in WO 2015 / 197468. Formula (I) TIFF2025035589000001.tif3872

[0011] The composition of the present invention is usually a formulation prepared by mixing epirifenacil and methoproxibicyclon with a solid or liquid carrier, and adding formulation auxiliary such as surfactant as necessary.Preferable formulation forms of such formulations are aqueous suspension concentrate, oil dispersion, wettable powder, water dispersible granule, granule, aqueous emulsion, oil-in-water, oil-in-oil, and emulsifiable concentrate.More preferred formulation form is emulsion. The content of epirifenacil in the composition of the present invention is usually in the range of 0.01 to 80% by weight, preferably 0.1 to 50% by weight. Specific examples of the content of epirifenacil in the composition of the present invention include 1% by weight, 2% by weight, 3% by weight, 4% by weight, 5% by weight, 6% by weight, 7% by weight, 8% by weight, 9% by weight, 10% by weight, 11% by weight, 12% by weight, 13% by weight, 14% by weight, 15% by weight, 20% by weight, 30% by weight, and 40% by weight. The content of methoproxibicyclon in the composition of the present invention is usually in the range of 0.01 to 80% by weight, preferably 0.1 to 50% by weight. Specific examples of the content of methoproxibicyclon in the composition of the present invention include 5% by weight, 6% by weight, 7% by weight, 8% by weight, 9% by weight, 10% by weight, 12% by weight, 14% by weight, 16% by weight, 18% by weight, 20% by weight, 25% by weight, 30% by weight, 35% by weight, 40% by weight, and 45% by weight. The total content of epirifenacil and methoproxibicyclon in the composition of the present invention is usually in the range of 0.01 to 99% by weight, preferably 1 to 80% by weight. Specific examples of the total content of epirifenacil and methoproxibicyclon in the composition of the present invention include 2% by weight, 4% by weight, 5% by weight, 8% by weight, 10% by weight, 15% by weight, 20% by weight, 25% by weight, 30% by weight, 40% by weight, 50% by weight, 60% by weight, 70% by weight, and 90% by weight.

[0012] The weight ratio of epirifenacil to methoproxibicyclon in the composition of the present invention is usually in the range of 1:1 to 1:10. Specific examples of the weight ratio of epirifenacil to methoproxibicyclon in the composition of the present invention include 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, and 1:10. The weight ratios can also be expressed as "approximately". "Approximately" means plus or minus 10%, for example, approximately 1:5 means 1:4.5 to 1:5.5. "Approximately" can be used in the same sense not only for the weight ratios, but also for any numerical values ​​described in this specification, such as the amount of spray solution or application amount.

[0013] The composition of the present invention may contain an organic solvent as a liquid carrier. Examples of organic solvents that can be used in the composition of the present invention include aliphatic hydrocarbons (hexane, 1-hexene, cyclohexane, octane, isooctane, 1-heptene, d-limonene, pinene, hexadecane, etc.), aromatic hydrocarbons (alkylbenzenes (toluene, xylene, isopropylbenzene, p-diethylbenzene, etc.), alkylbenzene derivatives, alkylnaphthalenes, alkylnaphthalene derivatives, tetrahydronaphthalene, etc.), chlorinated hydrocarbons (monochloroethylene, dichloroethylene, trichloroethylene, tetra ... chloroethylene, dichloromethane, 1,1,1-trichloroethane, 1,1,2-trichloroethane, 1,2-dichloropropane, etc.), ketones (cyclohexanone, acetone, 2-heptanone, isophorone, mesityl oxide, methyl isoamyl ketone, methyl ethyl ketone, methyl isobutyl ketone, acetophenone, diacetone alcohol, methylcyclohexanone, etc.), esters (fatty acid esters (ethyl acetate, butyl acetate, amyl acetate, isoamyl acetate, isobornyl acetate, hexyl acetate, heptyl acetate, acetic acid octyl acetate, isopropyl myristate, methyl octanoate, methyl oleate, methyl laurate, dibutyl adipate, tributyl citrate, dibutyl phthalate, etc.), lactate esters (ethyl lactate, propyl lactate, etc.), carbonate esters (ethylene carbonate, propylene carbonate, butylene carbonate, diethyl carbonate, dibutyl carbonate, etc.), esterified polyols (glycerol acetate, glycol acetate, glycerin monoacetate, glycerin diacetate, glycerin triacetate, diethylene glycol abietate, dipropylene glycol dibenzoate, dipropylene glycol monomethyl ester, etc.), lactones (γ-butyl lactone, etc.), ethers (1,4-dioxane, tetrahydrofuran, dipropylene glycol methyl ether, ethylene glycol methyl ether, propylene glycol methyl ether, etc.), amides (N-octyl-caprolactam, N-dodecyl-caprolactam, N,N-dimethylformamide, fatty acid dimethylamides (N,N-dimethylacetamide, N,N-dimethyldecanamide, N,N-dimethyloctaneamide, etc.), alkylpyrrolidones (N-methylpyrrolidone, N-octylpyrrolidone, N-dodecylpyrrolidone, etc.), lactams (α-lactam, β-lactam, γ-lactam, δ-lactam, etc.), amines (octylamine, octylamine acetate, oleylamine, diethanolamine, laurylamine, etc.), alcohols (methanol, ethanol, butanol, propanol, isopropanol, butanol, amyl alcohol, hexanol, heptanol, octanol, 2-ethylhexanol, etc.), hexylene glycol, cyclohexanol, phenol, benzyl alcohol, methoxypropanol (1-methoxy-2-propanol), tetrahydrofurfuryl alcohol, furfuryl alcohol, polyethylene glycol, ethylene glycol, diethylene glycol, hexylene glycol, ethylene glycol methyl ether, diethylene glycol Lithium methyl ether, diethylene glycol butyl ether, triethylene glycol, propylene glycol methyl ether, dipropylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol butyl ether, dipropylene glycol methyl ether, dipropylene glycol ether, dipropylene glycol monomethyl ether, glycerin, etc.), mineral oils (naphtha, petroleum ether, kerosene, diesel oil, paraffin, olefin, etc.), oils derived from animals and plants, oils derived from plants (palm oil, rapeseed oil, castor oil, coconut oil, soybean oil and derivatives thereof, etc.), oils derived from animals (sardine oil, saury oil, whale oil and derivatives thereof, etc.), dimethyl sulfoxide, silicone oil, acetonitrile, propanenitrile, acid anhydrides (such as acetic anhydride), triethyl phosphate, oleic acid, propionic acid, lactic acid, xylene sulfonic acid.

[0014] When the composition of the present invention contains an organic solvent, the total content of the organic solvent contained in the composition of the present invention is usually 10 to 90% by weight. Specific contents of the organic solvent in the composition of the present invention include 15% by weight, 20% by weight, 25% by weight, 30% by weight, 35% by weight, 40% by weight, 50% by weight, 60% by weight, 70% by weight, and 80% by weight. In this case, it is preferable that one or both of epirifenacil and methoproxibicyclon are dissolved in the solvent.

[0015] The composition of the present invention is used to control weeds. The method of using the composition of the present invention is similar to the method of controlling weeds of the present invention described below. The composition of the present invention exerts a more synergistic herbicidal effect against a wide range of weeds than would be expected from the herbicidal effects of epirifenacil and methoproxibicyclon when used alone, and can effectively control a wide range of weeds in crop and vegetable fields, orchards, and non-agricultural lands where normal tillage and no-tillage cultivation is performed, without causing any problematic chemical damage to useful plants.

[0016] The compositions of the present invention may further contain other agriculturally active ingredients, such as insecticides, nematicides and fungicides, including neonicotinoid compounds, diamide compounds, carbamates, organophosphorus compounds, biological nematicides and other insecticides, as well as azole compounds, strobilurin compounds, metalaxyl compounds, SDHI compounds, other fungicides and plant growth regulators.

[0017] The weed control method of the present invention (hereinafter referred to as the method of the present invention) has a step of applying epirifenacil and methoproxybicyclon together or separately in any order (hereinafter referred to as the application step). The application step is carried out in a crop field, a vegetable field, an orchard, or a non-agricultural land, and in the application step, epirifenacil and methoproxybicyclon are applied to a place where weeds are occurring or occurring. When epirifenacil and methoproxybicyclon are applied together, the composition of the present invention may be used, or a composition containing epirifenacil and a composition containing methoproxybicyclon may be used in combination. When epirifenacil and methoproxybicyclon are applied separately, a composition containing epirifenacil is applied, and then a composition containing methoproxybicyclon is applied, or they are applied in the reverse order. The compositions containing epirifenacil and the compositions containing methoproxibicyclon are typically preparations prepared by mixing epirifenacil and methoproxibicyclon with carriers such as solid carriers and liquid carriers, respectively, and adding formulation auxiliary agents such as surfactants as necessary.

[0018] Methods for applying epirifenacil and methoproxibicyclon include, for example, spraying epirifenacil and methoproxibicyclon on soil (soil treatment) and spraying on emerged weeds (foliage treatment). Soil treatment and foliage treatment are usually carried out by mixing the composition of the present invention with water to obtain a spray solution, which is sprayed on soil or weeds using a sprayer. The amount of the spray solution is usually in the range of 50 to 1000 L / ha, and may be, for example, in the range of 100 to 500 L / ha or 140 to 300 L / ha. When epirifenacil and methoproxibicyclon are sprayed separately, a composition containing epirifenacil and a composition containing methoproxibicyclon are sprayed separately according to the method for spraying the composition of the present invention.

[0019] The application rate of epirifenacil and methoproxibicyclon in the method of the present invention is usually in the range of 1 to 10,000 g / ha, for example, 2 to 5,000 g / ha or 5 to 2,000 g / ha, in terms of the total amount of epirifenacil and methoproxibicyclon.

[0020] The application rate of epirifenacil in the method of the present invention is usually in the range of 15 to 40 g / ha, preferably in the range of 20 to 33 g / ha. Specific application rates of epirifenacil include, for example, 17, 22, 25, 30, and 35 g / ha.

[0021] The application rate of methoproxibicyclon in the method of the present invention is usually in the range of 40 to 150 g / ha, preferably in the range of 80 to 120 g / ha. Specific application rates of methoproxibicyclon include, for example, 50, 60, 70, 90, 100, 110, 130, and 140 g / ha.

[0022] The weight ratio of epirifenacil to methoproxibicyclon in the method of the present invention is usually in the range of 1:1 to 1:10. Specific examples of the weight ratio of epirifenacil to methoproxibicyclon in the method of the present invention include 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, and 1:10.

[0023] The spray liquid sprayed in the method of the present invention may contain an adjuvant. The type of adjuvant is not particularly limited, and when an oil-based adjuvant such as Agri-Dex or MSO (mineral oil such as paraffinic hydrocarbon, naphthenic hydrocarbon, aromatic hydrocarbon, or methylated seed oil esterified from vegetable oil (soybean oil or rapeseed oil)) is contained in the spray solution, the adjuvant concentration in the spray solution is 0.25%, 0.5%, 1%, 2%, 3%, 4%, 5%, or 6% (volume / volume). When a nonionic adjuvant such as Induce (polyoxyalkylene alkyl ether, polyoxyalkylene fatty acid ester, alkylaryl alkoxylate, or alkylaryl polyoxyalkylene glycol) is contained in the spray solution, the adjuvant concentration in the spray solution is 0.05%, 0.1%, 0.25%, or 0.5% (volume / volume). Other adjuvants include, for example, anionic adjuvants (substituted sulfonates) such as Gramin S, cationic adjuvants (polyoxyethyleneamines) such as Genamin T 200BM, and organosilicon adjuvants such as Silwet L77. The spray solution sprayed in the method of the present invention may further contain a drift reducing agent such as Intact (polyethylene glycol).

[0024] The pH and hardness of the spray solution prepared in the method of the present invention are not particularly limited, but the pH is usually in the range of 5 to 9, and the hardness is usually in the range of 0 to 500 ppm on the American hardness scale. The time period for applying epirifenacil and methoproxibicyclon is not particularly limited, but is usually between 5:00 a.m. and 9:00 p.m., the photon flux density at the application site is usually in the range of 10 to 2500 micromoles / m2 / sec, the temperature at the application site is usually in the range of 0 to 35 degrees Celsius, and the wind speed at the application site is usually 3 MPH or less. The spray pressure when applying epirifenacil and methoproxibicyclon is not particularly limited, but is usually in the range of 30 to 120 PSI, preferably in the range of 40 to 80 PSI.

[0025] Examples of the agricultural crop fields in which the application step is carried out in the method of the present invention include peanut fields, soybean (indeterminate, determinate, semi-determinate) fields, corn (horse-tooth, hard, soft, burst, glutinous, sweet, field corn) fields, wheat (bread wheat (hard, soft, medium, red, white), macaroni, spelt, club wheat, autumn-sown, spring-sown, and spring-sown) fields, and wheat (bread wheat (hard, soft, medium, red, white), macaroni, spelt, club wheat, autumn-sown, spring-sown, and spring-sown) fields. Examples of suitable fields include food crop fields such as barley (two-rowed barley (= beer barley), six-rowed barley, naked barley, and glutinous barley, each of which is sown in the fall and spring), forage crop fields such as sorghum fields and oat fields, industrial crop fields such as cotton (upland and pima varieties), rapeseed fields, and canola (autumn and spring sown types), and sugar crop fields such as sugar cane fields and sugar beet fields. Of these, soybean fields are preferred.

[0026] Vegetable fields in which the application step is carried out in the method of the present invention include fields in which Solanaceae vegetables (eggplant, tomato, green pepper, red pepper, potato, etc.) are grown, fields in which Cucurbitaceae vegetables (cucumber, pumpkin, zucchini, watermelon, melon, etc.) are grown, fields in which Brassicaceae vegetables (radish, turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, mustard, broccoli, cauliflower, etc.) are grown, fields in which Asteraceae vegetables (burdock, garland chrysanthemum, Examples of such fields include fields for cultivating lily family vegetables (green onions, onions, garlic, asparagus, etc.), fields for cultivating parsley family vegetables (carrots, parsley, celery, parsley, etc.), fields for cultivating chenopodiaceae vegetables (spinach, Swiss chard, etc.), fields for cultivating lamiaceae vegetables (perilla, mint, basil, lavender, etc.), strawberry fields, sweet potato fields, Chinese yam fields, taro fields, etc.

[0027] Examples of orchards in which the application step of the method of the present invention is carried out include orchards, tea gardens, mulberry gardens, coffee gardens, banana gardens, palm gardens, flower orchards, flower tree fields, nursery fields, tree nurseries, forests, gardens, etc. Examples of fruit trees include pome fruits (apples, European pears, Japanese pears, quince, quince, etc.), stone fruits (peaches, plums, nectarines, plums, cherries, apricots, prunes, etc.), citrus fruits (Satsuma mandarins, oranges, lemons, limes, grapefruits, etc.), nuts (chestnuts, walnuts, hazels, almonds, pistachios, cashew nuts, macadamia nuts, etc.), berries (grapes, blueberries, cranberries, blackberries, raspberries, etc.), persimmons, olives, loquats, etc.

[0028] Non-agricultural land in which the application step is carried out in the method of the present invention includes playgrounds, vacant lots, railroad tracks, parks, parking lots, roadsides, riverbeds, areas under power lines, residential areas, factory sites, and the like.

[0029] The crops grown in the agricultural crop fields or the like to which the application step is carried out in the method of the present invention are not particularly limited as long as they are plants of varieties generally grown as crops.

[0030] The above-mentioned plant varieties may be plants that can be produced by natural crossbreeding, plants that can be generated by mutation, F1 hybrid plants, transgenic plants (also called genetically modified plants), etc. These plants generally have characteristics such as imparting resistance to herbicides, accumulating toxic substances against pests, suppressing susceptibility to diseases, increasing yield potential, improving resistance to biotic and abiotic stress factors, accumulating substances, improving storage properties and processability.

[0031] An F1 hybrid plant is a first generation hybrid obtained by crossing two varieties of different lineages, and generally has hybrid vigor characteristics that are superior to those of either parent. A transgenic plant is a plant obtained by introducing a foreign gene from another organism such as a microorganism, and has characteristics that cannot be easily obtained by cross breeding, mutagenesis, or natural recombination in a natural environment.

[0032] The techniques for producing the above-mentioned plants include, for example, conventional breeding techniques, recombinant gene techniques, genomic breeding techniques, new breeding techniques, and genome editing techniques. Conventional breeding techniques are techniques for obtaining plants with desired properties through mutation or crossbreeding. Recombinant gene techniques are techniques for giving new properties to a certain organism (e.g., a microorganism) by extracting a desired gene (DNA) from the organism and introducing it into the genome of another target organism, and antisense or RNA interference techniques for giving new or improved characteristics by silencing other genes present in the plant. Genomic breeding techniques are techniques for using genome information to make breeding more efficient, and include DNA marker (also called genome marker or gene marker) breeding techniques and genomic selection. For example, DNA marker breeding is a method of selecting progeny having a desired useful trait gene from a large number of progeny by using a DNA marker, which is a DNA sequence that marks the location of a specific useful trait gene on the genome. This method has the advantage that the time required for breeding can be effectively shortened by analyzing the progeny of the cross using DNA markers when they are still young plants. Genomic selection is a method of creating a prediction formula from phenotype and genome information obtained in advance, and predicting characteristics from the prediction formula and genome information without evaluating the phenotype, which can contribute to the efficiency of breeding. New breeding techniques are a general term for breeding techniques that combine molecular biological techniques. Examples include cisgenesis / intragenesis, oligonucleotide-directed mutagenesis, RNA-dependent DNA methylation, genome editing, grafting onto GM rootstocks or scions, reverse breeding, agroinfiltration, and seed production technology (SPT). Genome editing technology is a technology that converts genetic information in a sequence-specific manner, and allows for deletion of base sequences, replacement of amino acid sequences, introduction of foreign genes, etc. For example, such tools include zinc finger nucleases (ZFN), TALEN, CRISPR / Cas9, CRISPR / Cpf1, and Meganuclease, which are capable of sequence-specific DNA cleavage, as well as sequence-specific genome modification technologies such as CAS9 nickase and Target-AID, which are created by modifying the aforementioned tools.

[0033] Examples of the above-mentioned plants include plants listed in the GM Approval Database on the electronic information site of the International Service for the Acquisition of Agri-Biotech Applications (ISAAA) (http: / / www.isaaa.org / ). More specifically, these include herbicide-resistant plants, pest-resistant plants, disease-resistant plants, plants with modified quality (e.g., increase or decrease in content or change in composition) of products (e.g., starch, amino acids, fatty acids, etc.), plants with modified fertility traits, abiotic stress-resistant plants, and plants with modified traits related to growth or yield.

[0034] Plants that have been conferred resistance to herbicides through genetic engineering technology also include plants that have been conferred resistance through genetic engineering technology to 4-hydroxyphenylpyruvate dioxygenase (hereinafter abbreviated as HPPD) inhibitors such as isoxaflutole, mesotrione, etc., acetolactate synthase (hereinafter abbreviated as ALS) inhibitors such as imidazolinone herbicides including imazethapyr and sulfonylurea herbicides including thifensulfuron-methyl, 5-enolpyruvylshikimate-3-phosphate synthase (hereinafter abbreviated as EPSPS) inhibitors such as glyphosate, glutamine synthase inhibitors such as glufosinate, auxin-type herbicides such as 2,4-D, dicamba, etc., oxynil herbicides including bromoxynil, and protoporphyrinogen oxidase (hereinafter abbreviated as PPO) inhibitors such as flumioxazin. Preferred herbicide-resistant transgenic plants are cereals such as wheat, barley, rye, and oats, canola, sorghum, soybean, rice, rapeseed, sugar beet, sugarcane, grape, lentil, sunflower, alfalfa, pome fruits, stone fruits, and vegetables such as coffee, tea, strawberry, turfgrass, tomato, potato, cucumber, and lettuce, more preferably cereals such as wheat, barley, rye, and oats, soybean, rice, vine, tomato, potato, and pome fruits.

[0035] Specific herbicide-tolerant plants are shown below. Glyphosate herbicide-resistant plants; obtained by introducing one or more of the following: glyphosate-resistant EPSPS gene (CP4 epsps) derived from Agrobacterium tumefaciens strain CP4; glyphosate metabolic enzyme gene (gat4601, gat4621) derived from Bacillus licheniformis with enhanced metabolic activity of the glyphosate metabolic enzyme (glyphosate N-acetyltransferase) gene by shuffling technology; glyphosate metabolic enzyme (glyphosate oxidase gene, goxv247) derived from Ochrobacterum anthropi strain LBAA; or EPSPS gene (mepsps, 2mepsps) with glyphosate-resistant mutation derived from maize. The main plants include alfalfa (Medicago sativa), Argentine canola (Brassica napus), cotton (Gossypium hirsutum L.), creeping bentgrass (Agrostis stolonifera), corn (Zea mays L.), Polish canola (Brassica rapa), potato (Solanum tuberosum L.), soybean (Glycine max L.), sugar beet (Beta vulgaris), and wheat (Triticum aestivum). Several glyphosate-tolerant transgenic plants are commercially available. For example, genetically modified plants expressing glyphosate-resistant EPSPS derived from Agrobacterium are sold under trade names including "Roundup Ready (registered trademark)", genetically modified plants expressing glyphosate-metabolizing enzymes derived from Bacillus bacteria whose metabolic activity has been enhanced by shuffling technology are sold under trade names such as "Optimum (registered trademark) GAT (trademark)" and "Optimum (registered trademark) Gly canola", and genetically modified plants expressing EPSPS with a glyphosate-resistant mutation derived from corn are sold under the trade name "GlyTol (trademark)".

[0036] Glufosinate herbicide-resistant plants; obtained by introducing one or more of the phosphinothricin N-acetyltransferase (PAT) gene (bar), a glufosinate-metabolizing enzyme derived from Streptomyces hygroscopicus, the phosphinothricin N-acetyltransferase (PAT) enzyme gene (pat), a glufosinate-metabolizing enzyme derived from Streptomyces viridochromogenes, or the synthetic pat gene (pat syn), derived from Streptomyces viridochromogenes strain Tu494. The main plants include Argentine canola (Brassica napus), chicory (Cichorium intybus), cotton (Gossypium hirsutum L.), corn (Zea mays L.), Polish canola (Brassica rapa), rice (Oryza sativa L.), soybean (Glycine max L.), and sugar beet (Beta vulgaris). Several glufosinate-tolerant transgenic plants are commercially available. Transgenic plants derived from Streptomyces hygroscopicus and Streptomyces viridochromogenes are sold under brand names including LibertyLink™, InVigor™, and WideStrike™.

[0037] Oxynil herbicide (e.g., bromoxynil)-resistant plants: transgenic plants resistant to oxynil herbicides, such as bromoxynil, which have been introduced with the nitrilase gene (bxn), an oxynil herbicide (e.g., bromoxynil)-metabolizing enzyme derived from Klebsiella pneumoniae subsp. Ozaenae. Major plants include Argentine canola (Brassica napus), cotton (Gossypium hirsutum L.), and tobacco (Nicotiana tabacum L.), and are sold under the brand names "Navigator(TM) canola" or "BXN(TM)".

[0038] ALS inhibitor-resistant plants: carnation (Dianthus caryophyllus) "Moondust(TM)", "Moonshadow(TM)", "Moonshade(TM)", "Moonlite(TM)", "Moonaqua(TM)", "Moonvista(TM)", "Moonique(TM)", "Moonpearl(TM)", "Moonberry(TM)", "Moonvelvet(TM)" introduced with the ALS gene (surB) for resistance to ALS inhibitors derived from tobacco (Nicotiana tabacum) as a selection marker; flax (Linum usitatissumum L.) "CDC Triffid Flax" introduced with the ALS gene (als) for resistance to ALS inhibitors derived from Arabidopsis thaliana; corn (Zea mays L.) "Optimum(TM)" resistant to sulfonylurea and imidazolinone herbicides introduced with the ALS gene (zm-hra) for resistance to ALS inhibitors derived from corn GAT™; Cultivance, a soybean that is resistant to imidazolinone herbicides and has an ALS inhibitor-resistant ALS gene (csr1-2) derived from Arabidopsis; Treus™, Plenish™, and Optimum GAT™, a soybean that is resistant to sulfonylurea herbicides and has an ALS inhibitor-resistant ALS gene (gm-hra) derived from soybean (Glycine max), are sold under the trade names. There is also cotton that has an ALS inhibitor-resistant ALS gene (S4-HrA) derived from tobacco (Nicotiana tabacum cv. Xanthi) introduced into it.

[0039] HPPD inhibitor-resistant plants: Soybeans that have both the HPPD gene (avhppd-03) for resistance to mesotrione derived from oat (Avena sativa) and the gene (pat) for the glufosinate-metabolizing enzyme phosphinothricin N-acetyltransferase (PAT) derived from Streptomyces viridochromogenes are sold under the brand name "Herbicide-tolerant Soybean line."

[0040] 2,4-D tolerant plants: Corn introduced with the aryloxyalkanoate dioxygenase gene (aad-1), a 2,4-D metabolic enzyme derived from Sphingobium herbicidovorans, is sold under the brand name Enlist™ Maize. Soybeans and cotton introduced with the aryloxyalkanoate dioxygenase gene (aad-12), a 2,4-D metabolic enzyme derived from Delftia acidovorans, are sold under the brand name Enlist™ Soybean.

[0041] Dicamba-resistant plants include soybeans and cottons that have been introduced with the dicamba monooxygenase gene (dmo), a dicamba-metabolizing enzyme derived from Stenotrophomonas maltophilia strain DI-6. Soybeans (Glycine max L.) that have been introduced with the glyphosate-resistant EPSPS gene (CP4 epsps) derived from Agrobacterium tumefaciens strain CP4, as well as the above genes, are sold under the name "Genuity (registered trademark) Roundup Ready (trademark) 2 Xtend (trademark)."

[0042] Examples of PPO inhibitor-resistant plants include plants to which the ability to produce PPO with reduced affinity for PPO inhibitors has been imparted by genetic engineering technology, and plants to which the ability to detoxify and degrade PPO inhibitors by cytochrome P450 monooxygenase has been imparted by genetic engineering technology. In addition, the plant may be a crop to which both the ability to produce PPO with reduced affinity for PPO inhibitors and the ability to detoxify and degrade PPO inhibitors by cytochrome P450 monooxygenase have been imparted by genetic engineering technology. These resistant plants can be found in patent literature such as WO2011085221, WO2012080975, WO2014030090, WO2015022640, WO2015022636, WO2015022639, WO2015092706, WO2016203377, WO2017198859, WO2018019860, WO2018022777, WO2017112589, WO2017087672, WO2017039969, WO2017023778, WO2018022777, and WO2019118726, as well as in non-patent literature (Pest Management Science, 61, 2005, 277-285).

[0043] Examples of commercially available transgenic plants that have been conferred herbicide tolerance include glyphosate-tolerant corn (Roundup Ready Corn), (Roundup Ready 2), (Agrisure GT), (Agrisure GT / CB / LL), (Agrisure GT / RW), (Agrisure 3000GT), (YieldGard VT Rootworm / RR2), and (YieldGard VT Triple); glyphosate-tolerant soybean (Roundup Ready Soybean) and (Optimum GAT); glyphosate-tolerant cotton (Roundup Ready Cotton) and (Roundup Ready Flex); glyphosate-tolerant canola (Roundup Ready Canola); glyphosate-tolerant alfalfa (Roundup Ready Alfalfa); glyphosate-tolerant rice (Roundup Ready Rice); glufosinate-tolerant corn (Roundup Ready 2), (Liberty Link), (Herculex 1), (Herculex RW", "Herculex Xtra", "Agrisure GT / CB / LL", "Agrisure CB / LL / RW" and "Bt10"; glufosinate tolerant cotton "FiberMax Liberty Link"; glufosinate tolerant rice "Liberty Link Rice"; glufosinate tolerant canola "in Vigor"; bromoxynil tolerant cotton "BXN"; and bromoxynil tolerant canola "Navigator" and "Compass".Further plants modified with respect to herbicides are widely known, for example alfalfa, apple, barley, eucalyptus, flax, grape, lentil, rapeseed, pea, potato, rice, sugar beet, sunflower, tobacco, tomato, turfgrass and wheat (see, for example, US5188642, US4940835, US5633435, US5804425, US5627061) that are tolerant to glyphosate; bean, cotton, soybean, pea, potato, sunflower, tomato, Tobacco, corn, sorghum and sugarcane (see, e.g., WO2008051633, US7105724 and US5670454); glufosinate-resistant soybeans, sugar beets, potatoes, tomatoes and tobacco (see, e.g., US6376754, US5646024, US5561236); 2,4-D-resistant cotton, peppers, apples, tomatoes, sunflowers, tobacco, potatoes, corn, cucumbers, wheat, soybeans, sorghum and millet (see, e.g., US6153401, US6100446, WO2005107437, US5608147 and see US5670454); canola, corn, millet, barley, cotton, mustard, lettuce, lentil, melon, foxtail millet, oat, nata, potato, rice, rye, sorghum, soybean, sugar beet, sunflower, tobacco, tomato and wheat (see, e.g., US5013659, WO2006060634, US4761373, US5304732, US6211438, US6211439 and US6222100) that are resistant to ALS inhibitors (e.g., sulfonylurea herbicides and imidazolinone herbicides), and in particular rice that is resistant to imidazolinone herbicides is known, and acetohydroxyacid synthase genes (acetohydroxyacid synthase Rice and the like having specific mutations in the chromosome (gene) (e.g., S653N, S654K, A122T, S653(At)N, S654(At)K, A122(At)T) are known (see, for example, US2003 / 0217381 and WO200520673).Barley, sugarcane, rice, corn, tobacco, soybean, cotton, rapeseed, sugar beet, wheat and potato are also known to be resistant to HPPD inhibitors (e.g. isoxazole herbicides such as isoxaflutole, triketone herbicides such as sulcotrione and mesotrione, pyrazole herbicides such as pyrazolinates and diketonitrile decomposition products of isoxaflutole) (see, for example, WO2004 / 055191, WO199638567, WO1997049816 and US6791014).

[0044] Examples of plants that have been conferred herbicide resistance by classical or genomic breeding techniques include "Clearfield Rice", "Clearfield Wheat", "Clearfield Sunflower", "Clearfield lentils", and "Clearfield canola" (BASF products) that are resistant to imidazolinone ALS inhibitors such as imazethapyr and imazamox; "STS soybean" that is resistant to sulfonylurea ALS inhibitors such as thifensulfuron methyl; "SRcorn", "Poast Protected (registered trademark)", and "STS corn" that are resistant to acetyl-CoA carboxylase inhibitors such as trione oxime and aryloxyphenoxypropionic acid herbicides that are resistant to sethoxydim. corn; ExpressSun (registered trademark) sunflower resistant to sulfonylurea herbicides such as tribenuron; Provisia (trademark) Rice resistant to acetyl-CoA carboxylase inhibitors such as quizalofop; and Triazine Tolerant Canola resistant canola.

[0045] Examples of plants that have been given herbicide resistance by genome editing include canola "SU Canola (registered trademark)" that has sulfonylurea herbicide resistance using the rapid trait development system (RTDS (registered trademark)). RTDS (registered trademark) corresponds to oligonucleotide-directed mutagenesis of genome editing technology, and is a technology that can introduce mutations without cutting the DNA in plants through Gene Repair Oligonucleotide (GRON), i.e., a chimeric oligonucleotide of DNA and RNA. Other examples include corn with reduced herbicide resistance and phytic acid content by deleting the endogenous gene IPK1 using zinc finger nuclease (see, for example, Nature 459, 437-441 2009); and rice that has been given herbicide resistance using CRISPR-Cas9 (see, for example, Rice, 7, 5 2014).

[0046] New breeding techniques for imparting herbicide resistance include grafting, and an example of imparting the properties of a GM rootstock to a scion is the use of the glyphosate-resistant Roundup Ready® soybean as a rootstock to impart glyphosate resistance to a non-transgenic soybean scion (see Weed Technology 27:412-416, 2013).

[0047] The above-mentioned plants include lines that have been imparted with two or more of the above-mentioned abiotic stress resistance, disease resistance, herbicide resistance, pest resistance, growth or yield traits, nutrient uptake, product quality, fertility traits, etc. using genetic engineering techniques, classical breeding techniques, genomic breeding techniques, new breeding techniques, genome editing techniques, etc., as well as lines that have been imparted with two or more traits possessed by parent lines by crossing plants with similar or different traits.

[0048] Commercially available plants that have been made resistant to two or more herbicides include, for example, cotton "GlyTol (trademark) LibertyLink (trademark)" and "GlyTol (trademark) LibertyLink (trademark)" that are resistant to glyphosate and glufosinate; corn "Roundup Ready (trademark) LibertyLink (trademark) Maize" that is resistant to glyphosate and glufosinate; soybean "Enlist (trademark) Soybean" that is resistant to glufosinate and 2,4-D; soybean "Genuity (registered trademark) Roundup Ready (trademark) 2 Xtend (trademark)" that is resistant to glyphosate and dicamba; corn and soybean "OptimumGAT (trademark)" that are resistant to glyphosate and ALS inhibitors; and genetically modified soybeans "Enlist E3 (trademark)" and "Enlist (trademark) Roundup Ready 2" that are resistant to three herbicides, glyphosate, glufosinate, and 2,4-D. Yield(R); Enlist(TM) Roundup Ready(TM) Corn 2, a genetically modified corn that is resistant to glyphosate, 2,4-D, and aryloxyphenoxypropionic acid (FOPs) herbicides; Enlist(TM) Roundup Ready(TM) Corn 2, a genetically modified corn that is resistant to glyphosate, 2,4-D, and aryloxyphenoxypropionic acid (FOPs) herbicides; Bollgard II(R) XtendFlex(TM) Cotton, a genetically modified cotton that is resistant to dicamba, glyphosate, and glufosinate; and Enlist(TM) Cotton, a genetically modified cotton that is resistant to three herbicides: glyphosate, glufosinate, and 2,4-D. Other genetically modified varieties that have been developed include cotton that is resistant to glufosinate and 2,4-D, cotton that is resistant to both glufosinate and dicamba, corn that is resistant to both glyphosate and 2,4-D, soybeans that are resistant to both glyphosate and HPPD herbicides, and genetically modified corn that is resistant to glyphosate, glufosinate, 2,4-D, aryloxyphenoxypropionic acid (FOPs) herbicides, and cyclohexadione (DIMs) herbicides.

[0049] Commercially available plants that have been given herbicide tolerance and pest resistance include, for example, corn "YieldGard Roundup Ready" and "YieldGard Roundup Ready 2" that are tolerant to glyphosate and resistant to corn borer; corn "Agrisure CB / LL" that is tolerant to glufosinate and resistant to corn borer; corn "Yield Gard VT Rootworm / RR2" that is tolerant to glyphosate and resistant to corn rootworm and corn borer; corn "Yield Gard VT Triple" that is tolerant to glyphosate and resistant to lepidopteran pests (Cry1F) (e.g., resistance to western bean cutworm, corn borer, black cutworm, and fall armyworm); corn "Herculex I" that is tolerant to glufosinate and resistant to lepidopteran pests (Cry1F) (e.g., resistance to western bean cutworm, corn borer, black cutworm, and fall armyworm); corn "YieldGard Corn Rootworm / Roundup Ready" that is tolerant to glyphosate and resistant to corn rootworm; 2"; Agrisure GT / RW corn with glufosinate resistance and coleopteran resistance (Cry3A) (e.g., resistance to western corn rootworm, northern corn rootworm, and Mexican corn rootworm); Herculex RW corn with glufosinate resistance and coleopteran resistance (Cry34 / 35Ab1) (e.g., resistance to western corn rootworm, northern corn rootworm, and Mexican corn rootworm); Yield Gard VT Root worm / RR2 corn with glyphosate resistance and corn rootworm resistance; and Bollgard 3 (registered trademark) XtendFlex (registered trademark) cotton with dicamba resistance, glyphosate resistance, glufosinate resistance, and lepidopteran resistance (e.g., resistance to bollworms, tobacco budworms, armyworms, etc.).

[0050] The nozzle used when applying epirifenacil and methoproxibicyclon in the method of the present invention may be a flat fan nozzle or a drift-reducing nozzle. Flat fan nozzles include Teejet's Teejt110 series and XR Teejet110 series. When these are used at normal spray pressures, typically in the range of 30 to 120 PSI, the volume median diameter of droplets discharged from the nozzle is usually less than 430 microns. A drift-reducing nozzle is a nozzle in which drift is reduced compared to a flat fan nozzle, and is called an air induction nozzle or a pre-orifice nozzle. The volume median diameter of droplets discharged from a drift-reducing nozzle is usually 430 microns or more.

[0051] The air induction nozzle is a nozzle that has an air introduction section between the inlet (chemical introduction section) and the outlet (chemical discharge section) of the nozzle, and forms droplets filled with air by mixing air into the chemical. Examples of air induction nozzles include TDXL11003-D, TDXL11004-D1, TDXL11005-D1, and TDXL11006-D from Green Leaf Technology, TTI110025, TTI11003, TTI11004, TTI11005, TTI11006, and TTI11008 from Teejet, and ULD120-041, ULD120-051, and ULD120-061 from Pentair. A particularly preferred air induction nozzle is TTI11004.

[0052] A pre-orifice nozzle is a nozzle in which the nozzle inlet (chemical introduction part) is a metering orifice, which restricts the flow rate into the nozzle and reduces the pressure inside the nozzle to form large droplets. This reduces the pressure at the time of discharge by about half compared to before introduction. Examples of pre-orifice nozzles include Wilger's DR110-10, UR110-05, UR110-06, UR110-08, and UR110-10, and Teejet's 1 / 4TTJ08 Turf Jet and 1 / 4TTJ04 Turf Jet.

[0053] The sprayer used in applying epirifenacil and methoproxibicyclon in the method of the present invention may be a hooded sprayer certified by the U.S. Environmental Protection Agency (EPA) as a drift reduction technology (DRT). Examples of hooded sprayers certified by the DRT include REDBALL 642, REDBALL 642E, REDBALL SPK645, REDBALL 645, REDBALL 645T, REDBALL SP645, and REDBALL ATV642, all of which are manufactured by Willmar Fabrication LLC.

[0054] When the method of the present invention is carried out in a field where crops are grown, such as a crop field, epirifenacil and methoproxibicyclon may be applied before sowing the crops, or epirifenacil and methoproxibicyclon may be applied simultaneously with and / or after sowing the crops. That is, the number of times epirifenacil and methoproxibicyclon are applied can be, for example, once before, simultaneously with, or once after sowing the crop, twice excluding before sowing, twice excluding simultaneously with sowing, or twice excluding after sowing, and three times, applied at all of the times before, simultaneously with, and after sowing.

[0055] When epirifenacil and methoproxibicyclon are applied before sowing of a crop, epirifenacil and methoproxibicyclon are usually applied from 50 days before sowing to just before sowing, preferably from 30 days before sowing to just before sowing, more preferably from 20 days before sowing to just before sowing, and even more preferably from 10 days before sowing to just before sowing. When epirifenacil and methoproxibicyclon are applied after sowing of a crop, epirifenacil and methoproxibicyclon are usually applied from immediately after sowing to before flowering, preferably from immediately after sowing to before emergence, or during the 1 to 6 true leaf stage of the crop. When epirifenacil and methoproxibicyclon are applied simultaneously with sowing of crops, a machine combining a seeder and a sprayer is used.

[0056] As described above, the method of applying epirifenacil and methoproxibicyclon includes soil treatment in which epirifenacil and methoproxibicyclon are applied to soil where weeds grow, and foliar treatment in which epirifenacil and methoproxibicyclon are applied to weeds that have grown and grown. When epirifenacil and methoproxibicyclon are applied to growing weeds, the treatment can be both foliar and soil treatment. The application time can be determined independently of the above-mentioned growth stage of the crop. For example, foliar treatment can be performed on growing weeds before sowing the crop, or soil treatment can be performed during the growth of the crop. These treatments can be uniformly applied to the land or spot treatments.

[0057] In the method of the present invention, spot treatment is a concept opposite to uniform area application of a herbicide, and means selective application of a herbicide to a place where weeds are growing or where weeds will occur. "Apply to a place" means application to the weeds or the soil where weeds are growing if weeds are growing, and means application to the soil of a place where weeds are expected to occur in the future if weeds have not yet occurred. Even when epirifenacil and methoproxybicyclon are sprayed to a certain extent to a place where weeds have not occurred or will not occur in the future due to scattering, transpiration, etc., it is included in spot treatment as long as it is not a uniform area treatment. In addition, only when all the places where weeds are growing or where weeds will occur in a continuous crop cultivation area are selectively treated is not considered to be spot treatment. In other words, even if a part of the cultivation area is treated in a surface area, or even if a part of the area where weeds grow or occur is not treated, if there is a spot-treated area in a continuous cultivation area of ​​the crop, it is included in the spot treatment. Spot treatment may be carried out while avoiding the crop, or may be carried out based only on the position of the weeds, regardless of the position of the crop.

[0058] Specific examples of spot treatment methods are given below. In the cultivated area of ​​the crop, epirifenacil and methoproxybicyclon may be applied visually using a handheld nozzle or a robot arm nozzle while the applicator is walking or riding on a device running on the ground or a flying device. Also, spot treatment may be performed by mapping the location where weeds grow or occur in advance and applying epirifenacil and methoproxybicyclon based on the map information. In application based on map information, in addition to the above-mentioned method, spot treatment may be performed by automatically or manually opening and closing the nozzle on the boom or the robot arm nozzle based on the position information of the applicator (obtained by GPS, etc.) and the map information while the applicator is running or flying. The map information may be created based on image information taken by a manned or unmanned flying object, etc., and may be created visually by an observer walking on the ground, an observer riding on a device running on the ground, or an observer riding on a flying device. Furthermore, a running or flying sprayer may be equipped with a function for detecting where weeds are growing or occurring, and may perform spot treatment using the boom or robot arm while performing real-time mapping. Such technology is described in patent documents (e.g., WO2018001893, WO2018036909) and non-patent documents (e.g., Crop Protection 26, 270-277, Weed Technology 17, 711-717, Applied Engineering in Agriculture. 30, 143-152). These technologies are a form of emerging agriculture called precision agriculture, smart agriculture, digital agriculture, etc., and the uneven spray pattern caused by the spot treatment is also called VRA (Variable Rate Application) as a term in the emerging agriculture. In addition, a technology in which a running sprayer performs spot treatment in real time while detecting growing weeds is known as "See & Spray" or "OSST (Optical Spot Spray Technology)".

[0059] The location of weed occurrence may be estimated based on the fact that the weed formed a vegetation patch in the past growing season, or may be estimated from the distribution of buried seeds in the soil, which may be investigated by soil sampling or remote sensing.

[0060] The method of the present invention exerts a synergistic herbicidal effect against a wide range of weeds that is greater than would be expected from the herbicidal effects of epirifenacil and methoproxibicyclon when used alone, and can effectively control a wide range of weeds in crop fields, vegetable fields, orchards, and non-agricultural land where normal tillage and no-tillage cultivation is practiced, without causing any problematic chemical damage to useful plants.

[0061] In the method of the present invention, other pesticide active ingredients, such as insecticides, nematicides and fungicides, may be used in combination. Such insecticides, nematicides and fungicides include neonicotinoid compounds, diamide compounds, carbamates, organophosphorus compounds, biological nematicides and other insecticides, as well as azole compounds, strobilurin compounds, metalaxyl compounds, SDHI compounds, other fungicides and plant growth regulators.

[0062] Specific examples of weeds that can be controlled by the composition or method of the present invention include, but are not limited to, the following weeds: Urticaceae: Urtica urens Polygonaceae weeds: Polygonum convolvulus, Polygonum lapathifolium, Polygonum pensylvanicum, Polygonum persicaria, Polygonum longisetum, Polygonum aviculare, Polygonum arenastrum, Polygonum cuspidatum, Rumex japonicus, Rumex crispus, Rumex obtusifolius, Rumex acetosa Portulacaceae weeds: Portulaca oleracea Caryophyllaceae: Chickweed (Stellaria media), Cow chickweed (Stellaria aquatica), Earweed (Cerastium holosteoides), Dutch earweed (Cerastium glomeratum), Common clover (Spergula arvensis), Silene gallica Molluginaceae: Mollugo verticillata Chenopodiaceae: Chenopodium album, Chenopodium ambrosioides, Kochia scoparia, Salsola kali, Atriplex spp.

[0063] Amaranthaceae: Amaranthus retroflexus, Amaranthus viridis, Amaranthus lividus, Amaranthus spinosus, Amaranthus hybridus, Amaranthus palmeri, Amaranthus patulus, Amaranthus tuberculatus = Amaranthus rudis = Amaranthus tamariscinus, Amaranthus blitoides, Amaranthus deflexus, Amaranthus quitensis, Alternanthera philoxeroides), Alternanthera sessilis, Sanguinaria (Alternanthera tenella) Papaveraceae: Corn poppy (Papaver rhoeas), Corn poppy (Papaver dubium), Argemone mexicana Brassicaceae: Wild radish (Raphanus raphanistrum), radish (Raphanus sativus), field mustard (Sinapis arvensis), shepherd's purse (Capsella bursa-pastoris), mustard (Brassica juncea), rapeseed (Brassica napus), burdock grass (Descurainia pinnata), burdock root (Rorippa islandica), shepherd's purse (Rorippa sylvestris), shepherd's purse (Thlaspi arvense), watercress (Myagrum rugosum), shepherd's purse (Lepidium virginicum), shepherd's purse (Coronopus didymus) Capparaceae weeds: Cleome affinis

[0064] Legume weeds (Fabaceae): Aeschynomene indica, Aeschynomene rudis, Sesbania exaltata, Cassia obtusifolia, Cassia occidentalis, Desmodium tortuosum, Desmodium adscendens, Desmodium illinoense, Trifolium repens, Pueraria lobata, Vicia angustifolia, Indigofera hirsuta, Indigofera truxillensis, Vigna sinensis Oxalidaceae: Wood sorrel (Oxalis corniculata), wood sorrel (Oxalis stricta), Oxalis oxyptera Geraniaceae weeds: Geranium carolinense, Erodium cicutarium Euphorbiaceae: Euphorbia helioscopia, Euphorbia maculata, Euphorbia humistrata, Euphorbia esula, Euphorbia heterophylla, Euphorbia brasiliensis, Acalypha australis, Croton glandulosus, Croton lobatus, Phyllanthus corcovadensis, Ricinus communis

[0065] Malvaceae: Abutilon theophrasti, Sida rhombifolia, Sida cordifolia, Sida spinosa, Sida glaziovii, Sida santaremnensis, Hibiscus trionum, Anoda cristata, Malvastrum coromandelianum Onagraceae: Ludwigia epilobioides, Ludwigia octovalvis, Ludwigia decurrens, Oenothera biennis, Oenothera laciniata Sterculiaceae: Waltheria indica Violaceae: Viola arvensis, Viola tricolor Cucurbitaceae: Sichyos angulatus, Echinocystis lobata, Momordica charantia Weeds of the Lythraceae family: Ammannia multiflora, Ammannia auriculata, Ammannia coccinea, Lythrum salicaria, Rotala indica Elatinaceae: Elatine triandra, California waterwort

[0066] Apiaceae: Oenanthe javanica, Daucus carota, Conium maculatum Araliaceae: Hydrocotyle sibthorpioides, Hydrocotyle ranunculoides Ceratophyllaceae: Ceratophyllum demersum Cabombaceae: Cabomba caroliniana Haloragaceae: Myriophyllum aquaticum, Myriophyllum verticillatum, watermilfoils (Myriophyllum spicatum, Myriophyllum heterophyllum, etc.) Sapindaceae weeds: Cardiospermum halicacabum Primulaceae weeds: Anagallis arvensis Asclepiadaceae: Giant milkweed (Asclepias syriaca), Honeyvine milkweed (Ampelamus albidus) Rubiaceae: Catchweed bedstraw (Galium aparine), Cleaver grass (Galium spurium var. echinospermon), Broadleaf grass (Spermacoce latifolia), Brazilian false grass (Richardia brasiliensis), Winged buttonweed (Borreria alata)

[0067] Convolvulaceae weeds: Ipomoea nil, Ipomoea hederacea, Ipomoea purpurea, Ipomoea hederacea var. integriuscula, Ipomoea lacunosa, Ipomoea triloba, Ipomoea acuminata, Ipomoea hederifolia, Ipomoea coccinea, Ipomoea quamoclit, Ipomoea grandifolia, Ipomoea aristolochiaefolia, Ipomoea cairica), European bindweed (Convolvulus arvensis), Calystegia hederacea, Calystegia japonica, Merremia hederacea, Hairy wood rose (Merremia aegyptia), Roadside wood rose (Merremia cissoides), Morning glory (Jacquemontia tamnifolia) Boraginaceae: Forget-me-not (Myosotis arvensis) Lamiaceae: Lamium purpureum, Lamium amplexicaule, Leonotis nepetaefolia, Hyptis suaveolens, Hyptis lophanta, Leonurus sibiricus, Stachys arvensis

[0068] Solanaceae: Datura stramonium, Solanum nigrum, Solanum americanum, Solanum ptycanthum, Solanum sarrachoides, Solanum rostratum, Solanum aculeatissimum, Solanum sisymbriifolium, Solanum carolinense, Physalis angulata, Physalis subglabrata, Nicandra physalodes Scrophulariaceae weeds: Veronica hederaefolia, Veronica persica, Veronica arvensis, Lindernia procumbens, Lindernia dubia, Lindernia angustifolia, Bacopa rotundifolia, Dopatrium junceum, Gratiola japonica Plantaginaceae: Plantago asiatica, Plantago lanceolata, Plantago major, Callitriche palustris

[0069] Asteraceae weeds: Xanthium pensylvanicum, Xanthium occidentale, Xanthium italicum, Helianthus annuus, Matricaria chamomilla, Matricaria perforata, Chrysanthemum segetum, Matricaria matricarioides, Artemisia princeps, Artemisia vulgaris, Artemisia verlotorum, Solidago altissima, Taraxacum officinale, Galinsoga ciliata, Galinsoga parviflora, Senecio vulgaris, Senecio brasiliensis, Senecio grisebachii, Conyza bonariensis, Conyza smatrensis, Conyza canadensis, Ambrosia artemisiifolia, Ambrosia trifida, Bidens tripartita, Bidens pilosa, Bidens frondosa, Bidens subalternans, Cirsium arvense, Cirsium vulgare), Milk thistle (Silybum marianum), Musk thistle (Carduus nutans), Lactuca serriola, Cornus oleraceus, Sonchus asper, Beach creeping oxeye (Wedeliaglauca, Melampodium perfoliatum, Emilia sonchifolia, Tagetes minuta, Blainvillea latifolia, Tridax procumbens, Porophyllum ruderale, Acanthospermum australe, Acanthospermum hispidum, Cardiospermum halicacabum, Ageratum conyzoides, Eupatorium perfoliatum, Erechtites hieracifolia, Gamochaeta spicata, Gnaphalium spicatum, Jaegeria hirta, Parthenium hysterophorus, Siegesbeckia orientalis, Soliva sessilis, Eclipta prostrata, Eclipta alba, Centipeda minima

[0070] Alismataceae weeds: Sagittaria pygmaea, Sagittaria trifolia, Sagittaria sagittifolia, Sagittaria montevidensis, Sagittaria aginashi, Alisma canaliculatum, Alisma plantago-aquatica Limnocharitaceae: Limnocharis flava Hydrocharitaceae: Frogbit (Limnobium spongia), Hydrilla verticillata, Common water nymph (Najas guadalupensis) Araceae weeds: Pistia stratiotes Duckweeds (Lemnaceae): Lemna aoukikusa, Lemna paucicostata, Lemna aequinoctialis, Spirodela polyrhiza, Wolffia spp. Potamogetonaceae: Potamogeton distinctus, pondweeds (Potamogeton crispus, Potamogeton illinoensis, Stuckenia pectinata, etc.) Liliaceae: Wild onion (Allium canadense), wild garlic (Allium vineale), nobile (Allium macrostemon) Pontederiaceae: Water hyacinth (Eichhornia crassipes), American whiteweed (Heteranthera limosa), water hyacinth (Monochoria korsakowii), and whiteweed (Monochoria vaginalis) Dayflower (Commelinaceae): Commelina communis, Commelina benghalensis, Commelina erecta, Murdannia keisak

[0071] Poaceae weeds: Echinochloa crus-galli, Echinochloa oryzicola, Echinochloa crus-galli var. formosensis, Echinochloa oryzoides, Echinochloa colona, ​​Echinochloa crus-pavonis, Setaria viridis, Setaria faberi, Setaria glauca, Setaria geniculata, Digitaria ciliaris, Digitaria sanguinalis, Digitaria horizontalis, Digitaria insularis, Eleusine indica, Poa annua, Poa trivialis, Poa pratensis, Alopecurus aequalis, Alopecurus myosuroides, Avena fatua, Sorghum halepense, Sorghum vulgare, Agropyron repens, Lolium multiflorum, Lolium perenne, Lolium rigidum, Bromus catharticus, Bromus sterilis, Bromus japonicus, Bromus secalinus, Bromus tectorum), Hordeum jubatum, Goat wheat (Aegilops cylindrica), Phalaris arundinacea, Phalaris arundinaceaminor), Silky bentgrass (Apera spica-venti), Panicum dichotomiflorum, Texas panicum (Panicum texanum), Guinea millet (Panicum maximum), American millet (Brachiaria platyphylla), Ruzigrass (Brachiaria ruziziensis), Alexander grass (Brachiaria plantaginea), Suriname grass (Brachiaria decumbens), Palisade grass (Brachiaria brizantha), Columbia grass (Brachiaria humidicola), Cenchrus echinatus, Cenchrus pauciflorus, Narco grass (Eriochloa villosa), Pennisetum setosum, African moustache grass (Chloris gayana), African moustache grass (Chloris virgata, Eragrostis pilosa, Rhynchelytrum repens, Dactyloctenium aegyptium, Ischaemum rugosum, Isachne globosa, Oryza sativa, Paspalum notatum, Paspalum maritimum, Paspalum distichum, Pennisetum clandestinum, Pennisetum setosum, Rottboellia cochinchinensis, Leptochloa chinensis, Leptochloa fascicularis), Leptochloa filiformis, Leptochloa panicoides, Leersia japonica, Leersiasayanuka, Leersia oryzoides, Glyceria leptorrhiza, Glyceria acutiflora, Glyceria maxima, Agrostis gigantea, Agrostis stolonifera, Cynodon dactylon, Dactylis glomerata, Eremochloa ophiuroides, Festuca arundinacea, Festuca rubra, Imperata cylindrica, Miscanthus sinensis, Switchgrass, Zoysia japonica)

[0072] Cyperaceae weeds: Cyperus microiria, Cyperus iria, Cyperus compressus, Cyperus difformis, Cyperus flaccidus, Cyperus globosus, Cyperus nipponicus, Cyperus odoratus, Cyperus serotinus, Cyperus rotundus, Cyperus esculentus, Kyllinga gracillima, Kyllinga brevifolia, Fimbristylis miliacea, Fimbristylis dichotoma, Eleocharis acicularis, Eleocharis kuroguwai, Schoenoplectiella hotarui, Schoenoplectiella juncoides, Schoenoplectiella wallichii, Schoenoplectiella mucronatus, Schoenoplectiella triangulatus, Schoenoplectiella nipponicus, Schoenoplectiella triqueter, Bolboschoenus koshevnikovii, Bolboschoenus fluviatilis Equisetaceae: Horsetail (Equisetum arvense), Horsetail (Equisetum palustre) Salviniaceae Weeds: Salvinia natans Azollaceae weeds: Azolla japonica, Azolla pinnata Marsileaceae: Marsilea quadrifolia Other: suckers of filamentous algae (Pithophora, Cladophora), mosses, liverworts, hornworts, cyanobacteria, ferns, perennial crops (pome fruits, stone fruits, berries, nuts, citrus, hops, grapes, etc.).

[0073] The above weeds are not particularly limited due to intraspecific mutations. In other words, weeds that have reduced sensitivity (also referred to as resistant) to a specific herbicide are also included in the weeds that can be controlled by the composition or method of the present invention. The reduced sensitivity may be due to a mutation at the target site (site of action mutation) or due to a factor other than site of action mutation (non-site of action mutation). Site of action mutations include those in which an amino acid substitution occurs in the protein that is the target site due to a mutation in the nucleic acid sequence portion (open reading frame) corresponding to the amino acid sequence of the protein, and those in which the protein at the target site is overexpressed due to a mutation such as deletion of a suppressor sequence in the promoter region, amplification of an enhancer sequence, or an increase in the copy number of a gene. Factors that cause reduced susceptibility due to non-acting site mutations include increased metabolism, poor absorption, poor transport, and excretion from the system. Examples of factors that cause increased metabolism include increased activity of metabolic enzymes such as cytochrome P450 monooxygenase, aryl acylamidase, esterase, and glutathione S-transferase. Examples of excretion from the system include transport to the vacuole by ABC transporters. Examples of herbicide resistant weeds include: Glyphosate Resistance: Examples of weeds with reduced susceptibility due to site mutations include weeds with one or more of the following amino acid substitutions in the EPSPS gene: Thr102Ile, Pro106Ser, Pro106Ala, Pro106Leu, and Pro106Thr. In particular, weeds with both Thr102Ile and Pro106Ser, and those with both Thr102Ile and Pro106Thr, are included. Weeds with glyphosate resistance that have these site mutations, such as goosegrass, mouse rye, ryegrass, and Bidens subalternans, are effectively controlled. Similarly, examples of glyphosate resistance due to site mutations include those with an increased copy number of the EPSPS gene (PNAS, 2018 115 (13) 3332-3337). According to the present invention, glyphosate-resistant weeds such as amaranth, water hemp, and kochia with an increased copy number of the EPSPS gene are effectively controlled. Examples of weeds with reduced susceptibility due to non-acting point mutations include glyphosate-resistant Artemisia gracilis, Rhaetophorum gracilis, and Rhaetophorum gracilis, which are resistant to glyphosate due to the involvement of ABC transporters, and these are effectively controlled by the present invention. Furthermore, as a non-acting point mutation, barnyard millet is known to have reduced susceptibility to glyphosate due to increased expression of aldo-keto reductase (Plant Physiology 181, 1519-1534), which is effectively controlled by the present invention. Furthermore, glyphosate-resistant large crabgrass due to non-acting mutations is known to have glyphosate resistance (Weed Biology and Management 18, 50-59), which is effectively controlled by the present invention. ALS-inhibited herbicide resistance: Examples of weeds with reduced susceptibility due to site-of-action mutations include weeds with mutations in the ALS gene that cause one or more of the following amino acid substitutions: Ala122Thr, Ala122Val, Ala122Tyr, Pro197Ser, Pro197His, Pro197Thr, Pro197Arg, Pro197Leu, Pro197Gln, Pro197Ala, Pro197Ile, Ala205Val, Ala205Phe, Asp376Glu, Asp376Gln, Asp376Asn, Arg377His, Trp574Leu, Trp574Gly, Trp574Met, Ser653Thr, Ser653Asn, Ser635Ile, Gly654Glu, and Gly645Asp. According to the present invention, ALS inhibitor-resistant weeds having these site-of-action mutations, such as Amaranthus retroflexus, Amaranthus retroflexus, Amaranthus retroflexus, waterhemp, and Kochia japonica, can be effectively controlled. Examples of weeds with reduced susceptibility due to non-site-of-action mutations include weeds that have become resistant to ALS inhibitors due to the involvement of CYP or GST, and these weeds can be effectively controlled by the present invention. Known examples of such weeds include Boumugi, which overexpresses CYP81A10 or CYP81A1v1, Echinochloa oryzicola, which overexpresses CYP81A12 or CYP81A21, and Black-legged foxtail, which overexpresses GSTF1 or GSTU2. ACCase inhibitor resistance: Examples of weeds with reduced susceptibility due to site mutation include weeds with one or more of the following amino acid substitutions in the ACCase gene: Ile1781Leu, Ile1781Val, Ile1781Thr, Trp1999Cys, Trp1999Leu, Ala2004Val, Trp2027Cys, Ile2041Asn, Ile2041Val, Asp2078Gly, Asp2078Glu, Cys2088Arg, Gly2096Ala, and Gly2096Ser. The present invention effectively controls ACCase inhibitor-resistant weeds with these site mutations. Examples of weeds with reduced susceptibility due to non-site mutation include weeds that have become resistant to ACCase inhibitors due to the involvement of CYP or GST, and the present invention effectively controls these weeds. Examples of these include Japanese barnyard grass overexpressing CYP81A10 or CYP81A1v1, barnyard grass overexpressing CYP81A12 or CYP81A21, and black-grass foxtail millet overexpressing GSTF1 or GSTU2. In addition, large crabgrass is known to be resistant to haloxyfop-methyl due to Trp2027Cys (Pesticide Biochemistry and Physiology 164, 1-6), but it can be effectively controlled by the present invention. PPO inhibitor resistance: Examples of reduced susceptibility of weeds due to site-of-effect mutations include weeds that have mutations in the PPO gene that result in one or more of the following amino acid substitutions, which are known to be or are predicted to be resistance mutations to carfentrazone-ethyl, fomesafen, or lactofen. Arg128Leu, Arg128Met, Arg128Gly, Arg128His, Arg128Ala, Arg128Cys, Arg128Glu, Arg128Ile, Arg128Lys, Arg128Asn, Arg128Gln, Arg128Ser, Arg128Thr, Arg128Val, Arg128Tyr, Gly210 deletion, Ala210 deletion, Gly210Thr, Ala210Thr, Gly211 deletion, Gly114Glu, Ser149Ile, Gly399Ala (all amino acid numbers are standardized to the sequence of PPO2 from Amaranthus palmeri). Usually, the PPO genes of weeds include the PPO1 gene and the PPO2 gene, and the mutation may be present in either the PPO1 gene or the PPO2 gene, or in both. The mutation is preferably present in the PPO2 gene. For example, Arg128Met means that there is a mutation in the 128th amino acid. In the PPO2 gene of ragweed, the mutation corresponds to the 98th amino acid (Weed Science 60, 335-344), and is known to be represented as Arg98Leu, but this Arg98 is the same as Arg128 in this specification.In the PPO genes of weeds that are the subject of the present invention, Arg128Met and Arg128Gly are known in Amaranthus retroflexus (Pest Management Science 73, 1559-1563), Arg128Gly is known in the PPO2 of waterhemp (Pest Management Science, 2019; 75: 3235-3244), Arg128Ile and Arg128Lys are known in the PPO2 of waterhemp (Pest Management Science, 2019; 75: 3235-3244), Arg128His is known as Arg132His in the PPO2 of Bouquet (WSSA annual meeting, 2018), and Gly114Glu, Ser149Ile, and Gly399Ala are known in the PPO2 of Amaranthus retroflexus (Frontiers in Plant Science 10, Article 568), and Ala210Thr is known as Ala212Thr in PPO1 of goosegrass (Pest Management Science, doi: 10.1002 / ps.5703). According to the present invention, PPO inhibitor-resistant weeds having these site mutations can be effectively controlled, but the PPO inhibitor-resistant weeds to be controlled are not limited to these. That is, not only ambrosia having the Arg128Leu, Arg128Met, Arg128Gly, Arg128His, Arg128Ala, Arg128Cys, Arg128Glu, Arg128Ile, Arg128Lys, Arg128Asn, Arg128Gln, Arg128Ser, Arg128Thr, Arg128Val, Arg128Tyr, Gly210 deficiency, Ala210 deficiency, Gly210Thr, Ala210Thr, Gly211 deficiency, Gly114Glu, Ser149Ile or Gly399Ala mutation in PPO1 or PPO2, but also, for example, waterhemp having the same mutation, ragweed having the same mutation, and dayflower having the same mutation, etc. are effectively controlled.Examples of weeds with reduced susceptibility due to non-acting site mutations include waterhemp and ambrosia, which have become resistant to PPO inhibitors due to the involvement of CYP or GST, and waterhemp, which has become resistant to carfentrazone-ethyl (PLOS ONE, doi: 10.1371 / journal.pone.0215431), but these can be effectively controlled by the present invention. Auxinic herbicide resistance: An example of an active point mutation is a mutation that causes Gly-Asn in the degron region of the AUX / IAA gene. Kochia quinqueradiata, Amaranthus retroflexus, and waterhemp that have this mutation can be effectively controlled by the present invention. Examples of non-active point mutations include dicamba-resistant Amaranthus retroflexus and 2,4-D-resistant waterhemp, which are suggested to be involved in CYP, and these can be effectively controlled by the present invention. The same applies to non-active point mutations involving GST. HPPD inhibitor resistance: Examples of weeds with reduced susceptibility due to non-acting site mutations include waterhemp and amplexicaule, which have become resistant to HPPD inhibitors due to the involvement of CYP or GST, and these can be effectively controlled by the present invention. One such example is amplexicaule, which is known to overexpress CYP72A219, CYP81B, or CYP81E8. Photosystem II inhibitor resistance: Examples of weeds with reduced susceptibility due to site mutation include weeds with one or more of the following amino acid substitutions in the psbA gene: Val219Ile, Ser264Gly, Ser264Ala, and Phe274Val. The present invention effectively controls Amaranthus retroflexus and waterhemp, which have these site mutations and are resistant to photosystem II inhibitors. Examples of weeds with reduced susceptibility due to non-site mutation include Amaranthus retroflexus and waterhemp, which are resistant to photosystem II inhibitors due to the involvement of CYP, GST, or AAA, and are effectively controlled by the present invention. One example of such weeds is Boumugi, which has overexpressed CYP71R4. Glutamate synthetase inhibitor resistance: An example of reduced susceptibility of weeds due to site-of-action mutations is a weed with a mutation that causes an amino acid substitution of Asp171Asn in the glutamine synthetase gene. According to the present invention, glutamine synthetase inhibitor-resistant weeds such as Amaranthus retroflexus and waterhemp having this mutation can be effectively controlled. Examples of reduced susceptibility of weeds due to non-site-of-action mutations include Amaranthus retroflexus and waterhemp that have become resistant to glufosinate due to the involvement of CYP or GST, and these can be effectively controlled by the present invention. An example of such weeds is Amaranthus retroflexus, which has overexpressed CYP72A219, CYP81B, or CYP81E8. Resistant weeds that have "combined" (stacked) resistance to two or more of the above groups (arbitrarily selected group 2, arbitrarily selected group 3, arbitrarily selected group 4, arbitrarily selected group 5, arbitrarily selected group 6, arbitrarily selected group 7, and arbitrarily selected group 8) are also effectively controlled. An example of a stacked resistant weed is waterhemp, which is resistant to all of photosystem II inhibitors, HPPD inhibitors, 2,4-D, PPO inhibitors, ALS inhibitors, and glyphosate, and is also effectively controlled. The stack may be a combination of active point mutations, a combination of non-active point mutations, or a combination of active and non-active point mutations.

[0074] The composition of the present invention may further contain another herbicide in addition to epirifenacil and methoproxybicyclon. Also, in the method of the present invention, another herbicide may be used in combination with epirifenacil and methoproxybicyclon. In addition to epirifenacil and methoproxibicyclon, herbicides which may be included in the compositions of the invention or which may be used in combination with epirifenacil and methoproxibicyclon in the methods of the invention include, for example, the following herbicides, which may also be mixed (tank-mixed) into compositions of the invention containing only epirifenacil and methoproxibicyclon as active ingredients: Glyphosate and its salts (isopropylammonium salt, ammonium salt, potassium salt, guanidine salt, dimethylamine salt, monoethanolamine salt, choline salt, BAPMA (N,N-bis-(aminopropyl)methylamine) salt), 2,4-D and its salts or esters (ammonium salt, butotyl ester, 2-butoxypropyl ester, butyl ester, diethylammonium salt, dimethylammonium salt, diolamine salt, dodecylammonium salt, ethyl ester, 2-ethylhexyl ester, heptylammonium salt, ammonium salt, isobutyl ester, isoctyl ester, isopropyl ester, isopropylammonium salt, lithium salt, meptyl ester, methyl ester, octyl ester, pentyl ester, propyl ester, sodium salt, tefuryl ester, tetradecylammonium salt, triethylammonium salt, tris(2-hydroxypropyl)ammonium salt, trolamine salt, choline salt), 2,4-DB and its salts or esters (dimethylammonium salt, isoctyl ester, choline salt), pyroxasulfone, dicamba and its salts or esters are esters (diglycolamine salt, dimethylammonium salt, diolamine salt, isopropylammonium salt, methyl ester, olamine salt, potassium salt, sodium salt, trolamine salt, BAPMA (N,N-bis-(aminopropyl)methylamine) salt, choline salt, TBA (tetrabutylammonium) salt, TBP (tetrabutylphosphonium) salt), MCPA and its salts or esters (dimethylammonium salt, 2-ethylhexyl ester, isoctyl ester, sodium salt, choline salt), MCPB, mecoprop (mecoprop p) and its salts or esters (dimethylammonium salt, diolamine salt, ethathyl ester, 2-ethylhexyl ester, isoctyl ester, methyl ester, potassium salt, sodium salt, trolamine salt, choline salt), mecoprop-P and its salts or esters (dimethylammonium salt, 2-ethylhexyl ester, isobutyl salt, potassium salt, choline salt), dichlorprop and its salts or esters (butotyl ester, dimethylammonium salt, 2-ethylhexyl ester,Isoctyl ester, methyl ester, potassium salt, sodium salt, choline salt), dichlorprop-P, dichlorprop-P-dimethylammonium, quinclorac, quinmerac, bromoxynil, bromoxynil-octanoate, dichlobenil, methiozolin, ioxynil, ioxynil-octanoate, di-allate, butyrate, tri-allate, phenmedipham, chlorpropham, desmedipham, asulam, phenisopham, benthiocarb benthiocarb, molinate, esprocarb, pyributicarb, prosulfocarb, orbencarb, EPTC, dimepiperate, swep, propachlor, metazachlor, alachlor, acetochlor, metolachlor, S-metolachlor, butachlor, pretilachlor, thenylchlor, aminocyclopyrachlor, aminocyclopyrachlor-methyl, aminocyclopyrachlor-potassium, trifluralin, pendimethalin, ethalfluralin, benfluralin, prodiamine, simazine, atrazine, propazine, cyanazine, ametryn, simetryn, dimethametryn, prometryn , indaziflam, icafolin-methyl, triaziflam, metribuzin, hexazinone, terbumeton, terbuthylazine, terbutryn, trietazine, isoxaben, diuron, linuron, metobromuron omuron, metoxuron, monolinuron, siduron, fluometuron, difenoxuron, methyl-daimuron, isoproturon, isouron, tebuthiuron, benzthiazuron, methabenzthiazuron, pro propanil, mefenacet, clomeprop, naproanilide, bromobutide, daimuron, cumyluron, diflufenzopyr, etobenzanid, bentazon, tridiphane, indanofan, amitrole,Fenchlorazole, clomazone, maleic hydrazide hydrazide, pyridate, chloridazon, norflurazon, bromacil, terbacil, lenacil, oxaziclomefone, cinmethylin, benfuresate, cafenstrole, flufenacet, pyrithiobac, pyrithiobac-sodium, pyriminobac, pyriminobac-methyl, bispyribac, bispyribac-sodium, pyribenzoxim, pyrimisulfan, pyriftalid riftalid, triafamone, fentrazamide, dimethenamid, dimethenamid-P, ACN, dithiopyr, triclopyr and its salts or esters (butotyl ester, triethylammonium salt), fluroxypyr, fluroxypyr-meptyl l), thiazopyr, aminopyralid and its salts (potassium salt, triisopropanol ammonium salt, choline salt), clopyralid and its salts (auramine salt, potassium salt, triethylammonium salt, choline salt), picloram and its salts (potassium salt, triisopropanol ammonium salt, choline salt), dalapon, chlorthiamid, Amidosulfuron, azimsulfuron, bensulfuron, bensulfuron-methyl, chlorimuron, chlorimuron-ethyl, cyclosulfamuron, ethoxysulfuron, flazasulfuron, flucetsulfuron osulfuron, flupyrsulfuron, flupyrsulfuron-methyl-sodium, foramsulfuron, halosulfuron, halosulfuron-methyl, imazosulfuron, mesosulfuron, mesosulfuron-methyl, mesosulfuron-methyl Metasulfuron, Nicosulfuron, Orthosulfamuron, Oxasulfuron, Primisulfuron, Primisulfuron-methyl, Propyrisulfuron, Pyrazosulfuron, Pyrazosulfuron-ethyl, Rim Sulfuron, sulfometuron, sulfometuron-methyl, sulfosulfuron, trifloxysulfuron-sodium, trifloxysulfuron, chlorsulfuron, cinosulfuron, ethametsulfuron,ethametsulfuron-methyl, iodosulfuron, iodosulfuron-methyl-sodium, iofensulfuron, iofensulfuron-sodium, metsulfuron, metsulfuron-methyl, prosulfuron, thifensulfuron, thifensulfuron-methyl, triasulfuron, tribenuron, tribenuron-methyl, triflusulfuron, triflusulfuron-methyl, tritosulfuron, Diflufenican, picolinafen, beflubutamid, norflurazon, fluridone, flurochloridone, flurtamone, rimisoxafen, benzobicyclon, bicyclopyrone, mesotrione, sulcotrione ulcotrione, tefuryltrione, tembotrione, isoxachlortole, isoxaflutole, benzofenap, pyrasulfotole, pyrazolinate, pyrazoxyfen, topramezone, tolpyralate, rancotrionate lancotrione-sodium, flupoxam, amicarbazone, bencarbazone, flucarbazone, flucarbazone-sodium, ipfencarbazone, propoxycarbazone, propoxycarbazone-sodium, thiencarbazone Thiencarbazone, thiencarbazone-methyl, cloransulam, cloransulam-methyl, diclosulam, florasulam, flumetsulam, metosulam, penoxsulam, pyroxsulam, imazamethabenz,Imazamethabenz-methyl, imazamox, imazamox-ammonium, imazapic, imazapic-ammonium, imazapyr, imazapyr-ammonium, imazaquin, imazaquin-ammonium, imazethapyr thapyr, imazethapyr-ammonium, clodinafop, clodinafop-propargyl, cyhalofop, cyhalofop-butyl, diclofop, diclofop-methyl, fenoxaprop, fenoxaprop-ethyl, fenoxaprop fenoxaprop-P, fenoxaprop-P-ethyl, fluazifop, fluazifop-butyl, fluazifop-P, fluazifop-P-butyl, haloxyfop, haloxyfop-methyl, haloxyfop-P, haloxyfop-P-m ethyl), metamifop, propaquizafop, quizalofop, quizalofop-ethyl, quizalofop-P, quizalofop-P-ethyl, alloxydim, clethodim, sethoxydim, tepraloxydim, tralkoxydim,Pinoxaden, fenoxasulfone, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-sodium, bialafos, anilofos, bensulide, butamifos, paraquat, para Paraquat-dichloride, diquat, diquat-dibromide, halauxifen, halauxifen-methyl, florpyrauxifen, florpyrauxifen-benzyl, flumiclorac-pentyl, fomesafen sodium salt n-sodium, lactofen, acifluorfen-sodium, aclonifen, bifenox, chlomethoxyfen, chlornitrofen, ethoxyfen-ethyl, fluorodifen, fluoroglycofen-ethyl, fluoronitrofen, halosaphene, nitrofen, nitrofluorfen, oxyfluorfen, cinidon-ethyl, profluazol, pyraclonil, oxadiargyl, oxadiazone, pentoxazone, fluazolate,Pyraflufen-ethyl, benzfendizone, butafenacil, fluthiacet-methyl, thidiazimin, azafenidin, carfentrazone-ethyl, sulfentrazone, flufenpyr-ethyl, flumioxazin, saflufenacil, thiafenacil, trifluthiacet-methyl Ludimoxadine (3S,4S)-N-(2-fluorophenyl)-1-methyl-2-oxo-4-[3-(trifluoromethyl)phenyl]-3-pyrrolidinecarboxamide, 4-amino-3-chloro-5-fluoro-6-(7-fluoro-1H-indol-6-yl)-2-pyridinecarboxylic acid and its salts, bixlozone, cyclopyranil, fenquinotrione, cyclopyrimorate and tetflupyrolimet.

[0075] In addition to epirifenacil and methoproxibicyclon, preferred herbicides which may be included in the compositions of the invention or which may be used in combination with epirifenacil and methoproxibicyclon in the methods of the invention include potassium glyphosate, guanidine glyphosate, dimethylamine glyphosate, monoethanolamine glyphosate, ammonium glufosinate, isopropylammonium glyphosate, diflufenican, rimisoxafen, icaforin-methyl, pyroxasulfone, dicamba diglycolamine, dicamba BAPMA, dicamba TBA, dicamba TBP, flumiclorac pentyl, clethodim, lactofen, S-metolachlor, metribuzin, flufenacet, nicosulfuron, rimsulfuron, acetochlor, mesotrione, isoxaflutole, chlorimuron-ethyl, thifensulfuron-methyl, cloransulam-methyl, and imazethapyr ammonium.

[0076] When the composition of the present invention contains another herbicide in addition to epirifenacil and metoproxibicyclon, or when another herbicide is used in addition to epirifenacil and metoproxibicyclon in the method of the present invention, the weight ratio of epirifenacil to the other herbicide is usually in the range of 1:0.01 to 1:1000, preferably in the range of 1:0.1 to 1:300. Specific examples of the ratio of epirifenacil to the other herbicide include 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:15, 1:20, 1:25, 1:30, 1:40, 1:50, 1:60, 1:70, 1:80, 1:90, 1:100, 1:150, 1:200, and 1:250. In this specification, when the active ingredient of the herbicide is a salt or ester (for example, potassium glyphosate, monoethanolamine glyphosate), the weight refers to the acid equivalent weight unless otherwise specified.

[0077] More preferred specific combinations of epirifenacil, methoproxibicyclon and one or more additional herbicides are listed below, where the numbers in parentheses represent the preferred application rates (g / ha). Epirifenacil (20) + Metoproxibicyclon (60, 100) Epirifenacil (20) + Metoproxibicyclon (60, 100) + Glyphosate potassium salt (1080) Epirifenacil (20) + Metoproxibicyclon (60, 100) + Flumioxazin (75) Epirifenacil (20) + Metoproxibicyclon (60, 100) + Imazethapyr (105) Epirifenacil (20) + Metoproxibicyclon (60, 100) + Fluroxypyr Meptyl (400) Epirifenacil (20) + Metoproxibicyclon (60, 100) + Clethodim (100) Epirifenacil (20) + Metoproxibicyclon (60, 100) + S-Metolachlor (864) Epirifenacil (20) + Metoproxibicyclon (60, 100) + Flumioxazin (75) + Glyphosate potassium salt (1080) Epirifenacil (20) + Metoproxibicyclon (60, 100) + Imazethapyr (105) + Glyphosate potassium salt (1080) Epirifenacil (20) + Metoproxibicyclon (60, 100) + Fluroxypyr meptyl (400) + Glyphosate potassium salt (1080) Epirifenacil (20) + Metoproxibicyclon (30, 50) + Clethodim (100) + Glyphosate potassium salt (1080) Epirifenacil (20) + Metoproxibicyclon (60, 100) + S-Metolachlor (864) + Glyphosate potassium salt (1080)

[0078] In the cultivation of the crops of the present invention, plant nutritional management as in general crop cultivation can be performed. The fertilization system may be based on Precision Agriculture or may be a uniform system as in the conventional practice. In addition, nitrogen fixing bacteria and mycorrhizal fungi can be inoculated in combination with seed treatment.

[0079] An example of a formulation is shown below. Formulation Example 1 5 grams of epirifenacil, 25 grams of methoproxibicyclon, 5.55 grams of Phenylsulfonat CAL (a mixture of 70% calcium dodecylbenzenesulfonate and 30% isobutanol, manufactured by Clariant), 5.55 grams of Emulsogen TS290 (polyoxyethylene tristyryl phenyl ether, manufactured by Clariant), and 58.9 grams of Aromatic 200ND Fluid (mainly C10-C13 alkyl naphthalene as aromatic hydrocarbon, manufactured by Exxon Mobile Chemical) are thoroughly mixed to obtain approximately 100 ml of a liquid formulation. Formulation Example 2 2 grams of epirifenacil, 6 grams of methoproxibicyclon, 7.65 grams of Phenylsulfonat CAL (a mixture of 70% calcium dodecylbenzenesulfonate and 30% isobutanol, manufactured by Clariant), 7.65 grams of Emulsogen TS290 (polyoxyethylene tristyryl phenyl ether, manufactured by Clariant), and 76.7 grams of Aromatic 200ND Fluid (mainly C10-C13 alkyl naphthalene as aromatic hydrocarbon, manufactured by Exxon Mobile Chemical) are thoroughly mixed to obtain approximately 100 ml of a liquid formulation. Formulation Example 3 Mix 4 grams of epirifenacil, 20 grams of methoproxibicyclon, 5 grams of Sorupol 2680X (a product prepared by diluting Sorupol 2680 (a mixture of nonionic and anionic surfactants) with xylene to 80% by weight, manufactured by Toho Chemical Industry Co., Ltd.), and 71 grams of cyclohexanone thoroughly to obtain approximately 100 ml of a liquid preparation. Formulation Example 4 Mix 1 gram of epirifenacil, 4 grams of methoproxibicyclon, 5 grams of Sorpol 2680X (a product prepared by diluting Sorpol 2680 (a mixture of nonionic and anionic surfactants) with xylene to 80% by weight, manufactured by Toho Chemical Industry Co., Ltd.), and 90 grams of cyclohexanone thoroughly to obtain approximately 100 ml of a liquid preparation. EXAMPLES

[0080] The present invention will be described below with reference to examples, but the present invention is not limited to these examples.

[0081] First, the evaluation criteria for the herbicidal effect and phytotoxicity to crops shown in the following examples are shown below. [Weed-killing effect and phytotoxicity to crops] The herbicidal effect is evaluated on a scale from 0 to 100, with a score of "0" indicating that there is no or almost no difference in the emergence or growth of the test weeds at the time of the survey compared to untreated control, and a score of "100" indicating that the test weeds are completely dead or the emergence or growth of the test weeds is completely suppressed. Damage to crops caused by pesticides is assessed as "harmless" if little damage is observed, "small" if slight damage is observed, "medium" if moderate damage is observed, and "large" if severe damage is observed.

[0082] Example 1 In a field that has not been tilled since the harvest of the previous crop (where glyphosate-resistant crabgrass and broadleaf grass have appeared or are appearing), the composition of the present invention of Formulation Example 1 is diluted with water containing 0.5% (v / v) of a spreading agent (Iharol Gold) to prepare a spray solution, and the composition of the present invention is sprayed over the field at a volume of 190 L / ha using a boom sprayer. At this time, the composition of the present invention is applied to the foliage of the growing weeds, and to the soil of the unemerged weeds. Five days after the day of application, soybean seeds are sown in the same field. 25 days after application (20 days after sowing), excellent herbicidal effects are confirmed. Meanwhile, harmlessness to soybeans is confirmed. Example 2 Plastic pots were filled with soil, and sowed with Loose Barley, Barnyardgrass, and PPO inhibitor-resistant water hemp. They were grown in a greenhouse, and when the heights of the weeds reached 20 cm, 30 cm, and 15 cm, respectively, a given amount of either epirifenacil EC (obtained by thoroughly mixing 5 g of epirifenacil, 7 g of Phenylsulfonat CAL, 7 g of Emulsogen TS290, and 81 g of Aromatic 200ND Fluid) or metroxibicyclon EC (obtained by thoroughly mixing 5 g of metroxibicyclon, 7 g of Phenylsulfonat CAL, 7 g of Emulsogen TS290, and 81 g of Aromatic 200ND Fluid) was diluted with water containing 1% (v / v) Agri-Dex, and sprayed uniformly from above with a sprayer to apply the spray solution to the foliage at a rate of 200 L / ha. The overall herbicidal effect was examined 3 weeks after treatment, and the results are shown in Table 1. The expected herbicidal effect when epirifenacil and methoproxibicyclon are used together was calculated from the herbicidal effect (A or B value) of each compound used alone using Colby's formula ((expected value) = 100-(100-A) x (100-B) / 100). Table 1 TIFF2025035589000002.tif31145 [Industrial Applicability]

[0083] The present invention makes it possible to control weeds with high effectiveness.

Claims

1. A herbicide composition comprising epirifenacil and methoproxibicyclon, wherein the weight ratio of epirifenacil to methoproxibicyclon is in the range of 1:1 to 1:

10.

2. 2. The herbicidal composition of claim 1, wherein the weight ratio of epirifenacil to metroproxibicyclon is approximately 1:

5.

3. 10. The herbicidal composition of claim 1 comprising at least one organic solvent.

4. A method for controlling weeds comprising the step of applying epirifenacil and methoproxibicyclon together or separately in any order, wherein the application rate of epirifenacil is in the range of 15 to 40 g / ha and the application rate of methoproxibicyclon is in the range of 40 to 150 g / ha.

5. 5. The method for controlling weeds according to claim 4, wherein epirifenacil and methoproxibicyclon are applied to a crop field.

6. 6. The method for controlling weeds according to claim 5, wherein the crop field is a soybean field.

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