System and method for safety syringe

Abstract

To provide a system and method suitable for a safety syringe.SOLUTION: One embodiment is directed to a system for injection, the system comprising: a syringe body defining an interior medicine chamber; a stopper member configured to be inserted into the interior medicine chamber to contain medicine in the medicine chamber; a plunger member configured to be manually manipulated to insert the stopper member relative to the syringe body; and a needle having proximal and distal ends, the proximal end having an anchoring geometry configured to be at least partially inserted into the stopper member so that upon retraction of the stopper member the needle is pulled proximally along with the stopper to be at least partially contained in the interior medicine chamber.SELECTED DRAWING: Figure 1B

Description

[Technical field]

[0001] Related Application Data This application claims the benefit under 35 U.S.C. § 119 to U.S. Provisional Application No. 61 / 984,033, filed April 24, 2014, U.S. Provisional Application No. 62 / 014,035, filed June 18, 2014, U.S. Provisional Application No. 62 / 059,110, filed October 2, 2014, U.S. Provisional Application No. 62 / 105,717, filed January 20, 2015, U.S. Provisional Application No. 62 / 117,672, filed February 18, 2015, and U.S. Provisional Application No. 62 / 150,761, filed April 21, 2015. The foregoing applications are incorporated by reference in their entireties into this application.

[0002] The present invention relates generally to injection systems, devices and processes for facilitating various levels of control over fluid injection, and more specifically to systems and methods relating to safety syringes in medical environments. [Background technology]

[0003] Countless syringes, such as the one shown in FIG. 1A (2), are consumed daily in medical environments. A typical syringe (2) comprises a tubular body (4), a plunger (6), and a needle (8). As shown in FIG. 1B, such syringes (2) may be utilized not only to inject fluids into a patient, but also to draw or expel fluids from or into a container, such as a medicine bottle, vial, bag, or other drug containment system (10). In fact, due to regulatory constraints in some countries, such as the United States, and concerns about maintaining sterility, when using a medicine bottle (10) with a syringe (2) as found in certain patient environments, such medicine bottles may have to be discarded after only a single patient use, generating medical waste from the bottle and residual medicine waste, and further contributing to periodic shortages of certain important medications. Referring to FIG. 2A, three luer type syringes (12) are shown, each having a distally disposed luer fitting geometry (14) that allows them to couple with other devices having similar mating geometry, such as the luer manifold assembly (16) shown in FIG. 2B. The luer fitting (14) of the syringe in FIG. 2A may be referred to as a "male" luer fitting, while that of FIG. 2B (18) may be referred to as a "female" luer fitting. One of the luer connections may be threaded (in which case this configuration may be referred to as a "luer lock" configuration), allowing the two sides to couple by relative rotation, which may be combined with a compressive load. In other words, one embodiment of a luer lock is configured to utilize rotation, possibly in conjunction with compression, to engage threads into a male fitting, which engages a flange onto the female fitting, bringing the devices together into a fluid-tight connection. In another embodiment, a tapered mating geometry may be utilized to provide a Luer engagement using compression, without threads or rotation (such configurations may be referred to as "slip-on" or "cone" Luer configurations). Although such Luer connections are said to be relatively safe for the operator, there is a risk of spillage / leakage of medication and of parts breaking during loading to provide the Luer connection. On the other hand, the use of needle injection configurations carries the risk of the sharp needle contacting or piercing a person or unwanted structures.For this reason, so-called "safety syringes" were developed.

[0004] One embodiment of a safety syringe (20) is shown in FIG. 3, in which a tubular shielding member (22) is spring-biased to cover the needle (8) when released from a locked position relative to the syringe body (4). Another embodiment of a safety syringe (24) is shown in FIGS. 4A-4B. In such a configuration, after full insertion of the plunger (6) into the syringe body (4), the retractable needle (26) is configured to retract (28, 26) back to a safe position within the tubular body (4) as shown in FIG. 4B. Such a configuration configured to collapse upon itself may be associated with issues of blood splashing / aerosolization, safe storage of preload energy that may cause malfunction and premature start, reduced accuracy in delivering the total dose injection due to residual dead space in the spring compression volume, and / or reduced retraction speed control that may be associated with pain and patient discomfort.

[0005] Further complicating the syringe market is the increasing demand for pre-filled syringe assemblies, such as those shown in FIGS. 5A and 5B, which generally comprise a syringe body or “drug containment delivery system” (34), a plunger tip, plug or stopper (36), and a distal seal or cap (35) that may fit over a luer-type fitting (FIG. 5A shows the cap 35 in place, while FIG. 5B removes the cap to illustrate the luer fitting 14). Drug fluid may reside in a volume or drug reservoir (40) between the distal seal and the distal end (37) of the plunger tip (36). The plunger tip (36) may comprise a standard butyl rubber material and may be coated with a biocompatible lubricious coating or the like to promote a preferred seal and relative movement to the associated syringe body structure and material. The proximal end of the syringe body (34) in FIG. 5B includes a conventional syringe flange (38), such as what is known as a “Gerresheimer” flange configuration. Syringe body (34) preferably comprises a translucent material, such as glass or a polymer. A plunger tip (36) may be positioned within syringe body (34) to form a containment volume within drug chamber or reservoir (40) and to assist in the ejection of associated fluid through the needle. The syringe body may define a substantially cylindrical shape (i.e., allowing a plunger tip 36 having a circular cross-sectional shape to establish a seal with the syringe body) or may be configured to have other cross-sectional shapes, such as an ellipse.

[0006] Such assemblies are desirable because they can be standardized and manufactured in precise volumes by a small number of manufacturers around the world who can meet all of the world's ever-changing regulations for filling, packaging, and drug / drug bond material selection and component use. However, such simple configurations will generally not meet the new global standards for single-use, safety, auto-disable, and needle-stick resistance. This has led certain suppliers to move to more "vertical" solutions, such as (41) featured in FIG. 5C, which attempt to meet all or at least part of the standards with one solution, and as a result of trying to meet these standards for many different scenarios, such products may have significant limitations (including some of those described above with reference to FIGS. 3-4B), relatively high inventory and utilization costs.

[0007] There is a need for improved injection systems that address the shortcomings of currently available configurations, and in particular a need for a safety syringe solution that can take advantage of the existing and relatively well-controlled supply chain of conventionally delivered pre-filled syringe assemblies such as those described with reference to Figures 5A-5B. The present invention provides, for example, the following: (Item 1) 1. A system for injection comprising: a. a syringe body and a distal needle junction defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having a proximal end and a distal end, the proximal end releasably connecting to the distal needle interface of the syringe body and at least partially retractable into the internal medication chamber upon manipulation of the plunger member relative to the syringe body to convert a plunger locking member from a locked state to an unlocked state, the plunger locking member interconnecting between the syringe body and the plunger member; The plunger locking member is disposed substantially within a lumen defined by the plunger member. (Item 2) Item 1, wherein the syringe body comprises a commercially available syringe body. (Item 3) Item 1, wherein the syringe body has a generally cylindrical geometry. (Item 4) 2. The system of claim 1, wherein the medicament chamber is configured to contain about 0.5 cc to about 5 cc of medicament. (Item 5) 5. The system of claim 4, wherein the medicament chamber is configured to contain a volume of medicament selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 6) Item 1 , the syringe body comprising a glass material. (Item 7) 2. The system of claim 1, wherein the syringe body comprises a polymeric material. (Item 8) 8. The system of claim 7, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 9) Item 1 , wherein the syringe body comprises a metal. (Item 10) 2. The system of claim 1, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 11) Item 11. The system of item 10, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 12) Item 11. The system of item 10, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 13) 2. The system of claim 1, wherein the syringe body defines a distal drug port. (Item 14) Item 14. The system of item 13, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 15) Item 15. The system of item 14, wherein the distal drug port has an inner diameter of about 1 mm. (Item 16) Item 16. The system of item 15, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 17) Item 1 , the system of item 1 , wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 18) Item 1 , the system having at least one anchor element configured to resist withdrawal after the needle has penetrated at least partially into the stopper member. (Item 19) Item 19. The system of item 18, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 20) Item 10. The system of item 1, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 21) Item 10. The system of item 1, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 22) 2. The system of claim 1, further comprising a sealant coating applied to at least a portion of the stopper to isolate a drug material from the stopper. (Item 23) 23. The system of claim 22, wherein the sealant coating comprises a PTFE film. (Item 24) Item 10. The system of item 1, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 25) 25. The system of claim 24, wherein the lubricant layer comprises a silicone oil. (Item 26) 2. The system of claim 1, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 27) 27. The system of claim 26, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 28) Item 1 , the system of item 1 , wherein the needle includes at least one radially protruding locking surface feature. (Item 29) 30. The system of claim 28, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 30) 30. The system of claim 29, wherein the piercing element comprises a pointed tip. (Item 31) Item 31. The system of item 30, wherein the piercing element comprises a solid structure having no lumen or aperture defined therethrough. (Item 32) 30. The system of claim 29, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 33) Item 30. The system of item 28, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 34) Item 34. The system of item 33, wherein the cannula member and hub member are formed from the same piece of material. (Item 35) Item 34. The system of item 33, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 36) Item 34. The system of item 33, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form a portion of the needle. (Item 37) Item 36. The system of item 35, wherein the hub member is formed from a single piece of tubing. (Item 38) Item 34. The system of item 33, wherein the proximal member comprises a piece of flat sheet metal having a proximal linkage joint. (Item 39) Item 33. The system of item 32, wherein the cannula member comprises metal. (Item 40) Item 33. The system of item 32, wherein the hub comprises a metal or plastic material. (Item 41) 33. The system according to claim 32, wherein the proximal member is made of a metal or plastic material. (Item 42) Item 1, the system further comprising an energy storage member operably coupled between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 43) Item 43. The system of item 42, wherein the plunger member comprises a plunger member body defining an interior volume, the energy storage member being housed substantially within the interior volume of the plunger member body. (Item 44) Item 44. The system of item 43, further comprising a locking member operatively coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 45) Item 45. The system of item 44, wherein the locking member comprises a trigger portion extending outside an internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 46) Item 46. The system of item 45, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 47) Item 43. The system of item 42, wherein the energy storage member is a spring. (Item 48) Item 48. The system of item 47, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 49) Item 48. The system of item 47, wherein the spring comprises an elastomeric polymer. (Item 50) 50. The system of claim 49, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 51) Item 43. The system of item 42, wherein the energy storage member comprises a solid pellet member. (Item 52) 52. The system of claim 51, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 53) Item 48. The system of item 47, wherein the spring includes a single generally helical shaped coil. (Item 54) Item 48. The system of item 47, wherein the spring includes a plurality of generally helical shaped coils. (Item 55) Item 55. The system of item 54, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 56) Item 55. The system of item 54, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 57) Item 56. The system of item 55, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 58) Item 58. The system of item 57, wherein the coaxially and longitudinally parallel aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 59) Item 43. The system of item 42, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 60) 2. The system of claim 1, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. (Item 61) Item 1 , the system of item 1 , wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 62) 2. The system of claim 1, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after an initial insertion of the plunger member into a predetermined position relative to the syringe body. (Item 63) Item 63. The system of item 62, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 64) Item 63. The system of item 62, further comprising a locking member operably coupled between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal interface engageable with a handle portion of the syringe body. (Item 65) Item 45. The system of item 44, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 66) Item 1, the system of item 1 further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 67) Item 67. The system of item 66, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 68) Item 69. The system of item 67, wherein the damping member comprises a plate aperture damping portion. Item 69. The system of item 68, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 70) Item 70. The system of item 68, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 71) Item 71. The system of item 70, wherein the plate aperture damper is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 72) Item 68. The system of item 67, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 73) Item 73. The system of item 72, wherein the storage start load is applied by a spring member operatively connected to the brake member. (Item 74) Item 73. The system of item 72, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 75) Item 74. The system of item 73, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 76) Item 75. The system of item 74, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 77) Item 67. The system of item 66, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 78) Item 78. The system of item 77, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 79) 2. The system of claim 1, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharpened distal end of the needle while also aligning the sharpened proximal end of the needle for mating with the syringe body upon deployment by a user. (Item 80) 80. The system of claim 79, wherein the needle shield removably couples to the needle by at least one snap-over detent joint. (Item 81) Item 81. The system of item 80, wherein the needle shield removably couples to the needle by at least two snap-over detent joints. (Item 82) Item 82. The system of item 81, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 83) Item 82. The system of item 81, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 84) 80. The system of claim 79, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 85) 2. The system of claim 1, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 86) Item 86. The system of item 85, further comprising an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal medication chamber and the extension member. (Item 87) 2. The system of claim 1, further comprising an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 88) 2. The system of claim 1, wherein the plunger member is configured to be manually retracted by an operator when the plunger locking member is in an unlocked state. (Item 89) Item 91. The system of item 88, wherein the distal end of the needle becomes structurally encapsulated within the internal medication chamber. (Item 90) Item 89. The system of item 88, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 1) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. A system comprising: a needle having a proximal end and a distal end, the proximal end comprising an anchor geometry configured to be at least partially inserted into the stopper member to pull the needle proximally with the stopper upon retraction of the stopper member and at least partially contained within the internal medication chamber. (Item 2) Item 1, wherein the syringe body comprises a commercially available syringe body. (Item 3) Item 1, wherein the syringe body has a generally cylindrical geometry. (Item 4) 2. The system of claim 1, wherein the medicament chamber is configured to contain about 0.5 cc to about 5 cc of medicament. (Item 5) 5. The system of claim 4, wherein the medicament chamber is configured to contain a volume of medicament selected from the group consisting of 0.5 cc, 1 cc, 2.25 cc, 3 cc, and 5 cc. (Item 6) Item 1 , the syringe body comprising a glass material. (Item 7) 2. The system of claim 1, wherein the syringe body comprises a polymeric material. (Item 8) 8. The system of claim 7, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 9) Item 1 , wherein the syringe body comprises a metal. (Item 10) 2. The system of claim 1, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 11) Item 11. The system of item 10, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 12) Item 11. The system of item 10, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 13) 2. The system of claim 1, wherein the syringe body defines a distal drug port. (Item 14) Item 14. The system of item 13, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 15) Item 15. The system of item 14, wherein the distal drug port has an inner diameter of about 1 mm. (Item 16) Item 16. The system of item 15, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 17) Item 1 , the system of item 1 , wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 18) Item 1 , the system having at least one anchor element configured to resist withdrawal after the needle has penetrated at least partially into the stopper member. (Item 19) Item 19. The system of item 18, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 20) Item 10. The system of item 1, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 21) Item 10. The system of item 1, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 22) 2. The system of claim 1, further comprising a sealant coating applied to at least a portion of the stopper to isolate a drug material from the stopper. (Item 23) 23. The system of claim 22, wherein the sealant coating comprises a PTFE film. (Item 24) Item 10. The system of item 1, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 25) 25. The system of claim 24, wherein the lubricant layer comprises a silicone oil. (Item 26) 2. The system of claim 1, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 27) 27. The system of claim 26, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 28) Item 1 , the system of item 1 , wherein the needle includes at least one radially protruding locking surface feature. (Item 29) 30. The system of claim 28, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 30) 30. The system of claim 29, wherein the piercing element comprises a pointed tip. (Item 31) Item 31. The system of item 30, wherein the piercing element comprises a solid structure having no lumen or aperture defined therethrough. (Item 32) 30. The system of claim 29, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 33) Item 30. The system of item 28, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 34) Item 34. The system of item 33, wherein the cannula member and hub member are formed from the same piece of material. (Item 35) Item 34. The system of item 33, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 36) Item 34. The system of item 33, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form a portion of the needle. (Item 37) Item 36. The system of item 35, wherein the hub member is formed from a single piece of tubing. (Item 38) Item 34. The system of item 33, wherein the proximal member comprises a piece of flat sheet metal having a proximal linkage joint. (Item 39) Item 37. The system of item 36, wherein the cannula member comprises metal. (Item 40) Item 37. The system of item 36, wherein the hub comprises a metal or plastic material. (Item 41) 37. The system of claim 36, wherein the proximal member is made of a metal or plastic material. (Item 42) Item 1, the system further comprising an energy storage member operably coupled between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 43) Item 43. The system of item 42, wherein the plunger member comprises a plunger member body defining an interior volume, the energy storage member being housed substantially within the interior volume of the plunger member body. (Item 44) Item 44. The system of item 43, further comprising a locking member operatively coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 45) Item 45. The system of item 44, wherein the locking member comprises a trigger portion extending outside an internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 46) Item 46. The system of item 45, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 47) Item 43. The system of item 42, wherein the energy storage member is a spring. (Item 48) Item 48. The system of item 47, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 49) Item 48. The system of item 47, wherein the spring comprises an elastomeric polymer. (Item 50) 50. The system of claim 49, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 51) Item 43. The system of item 42, wherein the energy storage member comprises a solid pellet member. (Item 52) 52. The system of claim 51, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 53) Item 48. The system of item 47, wherein the spring includes a single generally helical shaped coil. (Item 54) Item 48. The system of item 47, wherein the spring includes a plurality of generally helical shaped coils. (Item 55) Item 55. The system of item 54, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 56) Item 55. The system of item 54, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 57) Item 56. The system of item 55, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 58) Item 58. The system of item 57, wherein the coaxially and longitudinally parallel aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 59) Item 43. The system of item 42, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 60) 2. The system of claim 1, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. (Item 61) Item 1 , the system of item 1 , wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 62) 2. The system of claim 1, wherein the plunger member comprises one or more ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after an initial insertion of the plunger member into a predetermined position relative to the syringe body. (Item 63) Item 63. The system of item 62, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 64) Item 63. The system of item 62, further comprising a locking member operably coupled between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the one or more ratchet mechanisms and a proximal interface engageable with a handle portion of the syringe body. (Item 65) Item 45. The system of item 44, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 66) Item 1, the system of item 1 further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 67) Item 67. The system of item 66, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 68) Item 69. The system of item 67, wherein the damping member comprises a plate aperture damping portion. Item 69. The system of item 68, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 70) Item 69. The system of item 68, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 71) Item 71. The system of item 70, wherein the plate aperture damper is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 72) Item 68. The system of item 67, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 73) Item 73. The system of item 72, wherein the storage start load is applied by a spring member operatively connected to the brake member. (Item 74) Item 73. The system of item 72, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 75) Item 74. The system of item 73, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 76) Item 75. The system of item 74, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 77) Item 67. The system of item 66, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 78) Item 78. The system of item 77, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 79) 2. The system of claim 1, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharpened distal end of the needle while also aligning the sharpened proximal end of the needle for mating with the syringe body upon deployment by a user. (Item 80) 80. The system of claim 79, wherein the needle shield removably couples to the needle by at least one snap-over detent joint. (Item 81) Item 81. The system of item 80, wherein the needle shield removably couples to the needle by at least two snap-over detent joints. (Item 82) Item 82. The system of item 81, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 83) Item 82. The system of item 81, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 84) 80. The system of claim 79, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 85) 2. The system of claim 1, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 86) Item 86. The system of item 85, further comprising an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal medication chamber and the extension member. (Item 87) 2. The system of claim 1, further comprising an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 88) 2. The system of claim 1, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 89) Item 91. The system of item 88, wherein the distal end of the needle becomes structurally encapsulated within the internal medication chamber. (Item 90) Item 89. The system of item 88, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 91) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having a proximal end and a distal end; e. A coupling member operably connected to a syringe body and a needle, the coupling member having a first state in which the needle is releasably coupled to the syringe body and a second state in which the needle is freely retractable relative to the syringe body. (Item 92) Item 92. The system of item 91, wherein the coupling member is further configured to have a third state in which the needle is mechanically prevented from further insertion into the syringe body. (Item 93) Item 92. The system of item 91, wherein the syringe body comprises a commercially available syringe body. (Item 94) Item 92. The system of item 91, wherein the syringe body comprises a generally cylindrical geometry. (Item 95) Item 92. The system of item 91, wherein the medicament chamber is configured to contain about 0.5 cc to about 5 cc of medicament. (Item 96) Item 96. The system of item 95, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 97) Item 92. The system of item 91, wherein the syringe body comprises a glass material. (Item 98) Item 92. The system of item 91, wherein the syringe body comprises a polymeric material. (Item 99) Item 99. The system of item 98, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 100) Item 92. The system of item 91, wherein the syringe body comprises a metal. (Item 101) Item 92. The system of item 91, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 102) Item 102. The system of item 101, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 103) Item 102. The system of item 101, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 104) Item 92. The system of item 91, wherein the syringe body defines a distal drug port. (Item 105) Item 105. The system of item 104, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 106) Item 106. The system of item 105, wherein the distal drug port has an inner diameter of about 1 mm. (Item 107) Item 107. The system of item 106, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 108) Item 92. The system of item 91, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 109) Item 92. The system of item 91, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 110) Item 110. The system of item 109, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 111) Item 102. The system of item 101, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 112) Item 92. The system of item 91, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 113) 92. The system of claim 91, further comprising a sealant coating applied to at least a portion of the stopper to isolate a drug material from the stopper. (Item 114) Item 115. The system of item 113, wherein the sealant coating comprises a PTFE film. Item 92. The system of item 91, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 116) Item 116. The system of item 115, wherein the lubricant layer comprises a silicone oil. (Item 117) Item 92. The system of item 91, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 118) Item 118. The system of item 117, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 119) Item 102. The system of item 101, wherein the needle comprises at least one radially protruding locking surface feature. (Item 120) Item 120. The system of item 119, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 121) Item 121. The system of item 120, wherein the piercing element comprises a pointed tip. (Item 122) Item 122. The system of item 121, wherein the piercing element comprises a solid structure having no lumen or aperture defined therethrough. (Item 123) Item 121. The system of item 120, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 124) The system of claim 116, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 125) Item 125. The system of item 124, wherein the cannula member and hub member are formed from the same piece of material. (Item 126) Item 125. The system of item 124, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 127) Item 125. The system of item 124, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form a portion of the needle. (Item 128) Item 127. The system of item 126, wherein the hub member is formed from a single piece of tubing. (Item 129) Item 125. The system of item 124, wherein the proximal member comprises a piece of flat sheet metal having a proximal linkage joint. (Item 130) Item 128. The system of item 127, wherein the cannula member comprises metal. (Item 131) Item 128. The system of item 127, wherein the hub comprises a metal or plastic material. (Item 132) The proximal member may be made of a metal or plastic material. (Item 133) Item 92. The system of item 91, further comprising an energy storage member operably coupled between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 134) Item 134. The system of item 133, wherein the plunger member comprises a plunger member body defining an interior volume, the energy storage member being housed substantially within the interior volume of the plunger member body. (Item 135) Item 135. The system of item 134, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 136) Item 136. The system of item 135, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 137) Item 137. The system of item 136, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 138) Item 134. The system of item 133, wherein the energy storage member is a spring. (Item 139) Item 139. The system of item 138, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 140) Item 139. The system of item 138, wherein the spring comprises an elastomeric polymer. (Item 141) Item 141. The system of item 140, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 142) Item 143. The system of item 133, wherein the energy storage member comprises a solid pellet member. Item 143. The system of item 142, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 144) Item 139. The system of item 138, wherein the spring includes a single generally helical shaped coil. (Item 145) The system according to item 138, wherein the spring includes a plurality of generally helical coils. (Item 146) The system according to item 145, wherein at least two of the coils including the plurality of generally helical coils are coaxially aligned. (Item 147) The system according to item 145, wherein at least two of the coils including the plurality of generally helical coils are aligned parallel to each other in the longitudinal direction. (Item 148) The system according to item 146, wherein the coaxially aligned helical coils are also aligned parallel to each other in the longitudinal direction. (Item 149) The system according to item 148, wherein the helical coils that are coaxially and longitudinally aligned parallel to each other are helically wound in opposite winding directions with respect to each other so as to prevent interference between the coils when the coils are compressed. (Item 150) The system according to item 91, wherein the plunger is stored in the interconnected stopper member and the needle, and as a result, at least a part of the needle is drawn into the internal drug chamber of the syringe body. (Item 151) The system according to item 91, wherein the plunger includes a proximal thumb pad configured to facilitate manual insertion and storage control of the plunger with respect to the syringe body. (Item 152) The system according to item 91, comprising a plunger distal end screw joint, wherein the plunger is helically inserted into the stopper member and is configured to be connected to the stopper member by such insertion. (Item 153) Item 92. The system of item 91, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 154) Item 154. The system of item 153, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 155) Item 154. The system of item 153, further comprising a locking member operably coupled between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 156) Item 136. The system of item 135, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 157) Item 92. The system of item 91, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 158) Item 158. The system of item 157, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 159) Item 159. The system of item 158, wherein the damping member comprises a plate aperture damping portion. (Item 160) Item 160. The system of item 159, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 161) Item 160. The system of item 159, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 162) Item 162. The system of item 161, wherein the plate aperture damper is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 163) Item 159. The system of item 158, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 164) Item 164. The system of item 163, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 165) Item 164. The system of item 163, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 166) Item 165. The system of item 164, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 167) Item 166. The system of item 165, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 168) Item 158. The system of item 157, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 169) Item 169. The system of item 168, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 170) Item 92. The system of item 91, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharpened distal end of the needle while also aligning the sharpened proximal end of the needle for mating with the syringe body upon placement by a user. (Item 171) Item 171. The system of item 170, wherein the needle shield removably couples to the needle by at least one snap-over detent joint. (Item 172) Item 172. The system of item 171, wherein the needle shield removably couples to the needle by at least two snap-over detent joints. (Item 173) Item 173. The system of item 172, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 174) Item 173. The system of item 172, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 175) Item 171. The system of item 170, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 176) Item 92. The system of item 91, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 177) Item 177. The system of item 176, further comprising an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal medication chamber and the extension member. (Item 178) Item 92. The system of item 91, further comprising an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 179) Item 92. The system of item 91, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and such that subsequent access to the distal end of the needle is prevented. (Item 180) Item 180. The system of item 179, wherein the distal end of the needle becomes structurally encapsulated within the internal medication chamber. (Item 181) Item 179. The system of item 179, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 182) 1. A system for injection comprising: a syringe body defining an internal medication chamber and a distal needle junction; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber, the stopper member having a proximal end and a distal end; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having a proximal end and a distal end, the proximal end connecting to the distal needle interface of the syringe body; The system, wherein the distal end of the stopper member is configured to have no preformed needle coupling mechanism. (Item 183) Item 183. The system of item 182, wherein the distal end of the stopper member is configured to have a distal surface shape selected from the group consisting of a convex shape, a concave shape, a flat shape, and a conical shape. (Item 184) Item 183. The system of item 182, wherein the syringe body comprises a commercially available syringe body. (Item 185) Item 186. The system of item 182, wherein the syringe body comprises a generally cylindrical geometry. Item 183. The system of item 182, wherein the medicament chamber is configured to contain about 0.5 cc to about 5 cc of medicament. (Item 187) Item 187. The system of item 186, wherein the medicament chamber is configured to accommodate a volume of medicament selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 188) Item 183. The system of item 182, wherein the syringe body comprises a glass material. (Item 189) Item 183. The system of item 182, wherein the syringe body comprises a polymeric material. (Item 190) Item 189. The system of item 189, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 191) Item 183. The system of item 182, wherein the syringe body comprises a metal. (Item 192) Item 183. The system of item 182, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 193) Item 193. The system of item 192, wherein the syringe body includes a distal outer geometry of the syringe body that includes a luer lock junction. (Item 194) Item 193. The system of item 192, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 195) Item 183. The system of item 182, wherein the syringe body defines a distal drug port. (Item 196) Item 196. The system of item 195, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 197) Item 197. The system of item 196, wherein the distal drug port has an inner diameter of about 1 mm. (Item 198) Item 198. The system of item 197, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 199) Item 183. The system of item 182, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 200) Item 183. The system of item 182, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 201) Item 201. The system of item 200, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 202) Item 183. The system of item 182, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 203) Item 183. The system of item 182, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 204) Item 183. The system of item 182, further comprising a sealant coating applied to at least a portion of the stopper to isolate a drug material from the stopper. (Item 205) Item 206. The system of item 204, wherein the sealant coating comprises a PTFE film. Item 183. The system of item 182, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 207) Item 207. The system of item 206, wherein the lubricant layer comprises silicone oil. (Item 208) Item 183. The system of item 182, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 209) Item 209. The system of item 208, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 210) Item 183. The system of item 182, wherein the needle comprises at least one radially protruding locking surface feature. (Item 211) Item 211. The system of item 210, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 212) Item 212. The system of item 211, wherein the piercing element comprises a pointed tip. (Item 213) Item 213. The system of item 212, wherein the piercing element comprises a solid structure having no lumen or aperture defined therethrough. (Item 214) Item 212. The system of item 211, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 215) Item 211. The system of item 210, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 216) Item 216. The system of item 215, wherein the cannula member and hub member are formed from the same piece of material. (Item 217) Item 216. The system of item 215, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 218) Item 216. The system of item 215, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form part of the needle. (Item 219) Item 218. The system of item 217, wherein the hub member is formed from a single piece of tubing. (Item 220) Item 216. The system of item 215, wherein the proximal member comprises a piece of flat sheet metal having a proximal linkage joint. (Item 221) Item 219. The system of item 218, wherein the cannula member comprises metal. (Item 222) Item 219. The system of item 218, wherein the hub comprises a metal or plastic material. (Item 223) The proximal member may be made of a metal or plastic material, the system being described in item 218. (Item 224) Item 183. The system of item 182, further comprising an energy storage member operably coupled between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 225) Item 225. The system of item 224, wherein the plunger member comprises a plunger member body defining an interior volume, the energy storage member being housed substantially within the interior volume of the plunger member body. (Item 226) Item 226. The system of item 225, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 227) Item 227. The system of item 226, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 228) Item 228. The system of item 227, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 229) Item 225. The system of item 224, wherein the energy storage member is a spring. (Item 230) Item 230. The system of item 229, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 231) Item 230. The system of item 229, wherein the spring comprises an elastomeric polymer. (Item 232) 232. The system of claim 231, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 233) Item 234. The system of item 224, wherein the energy storage member comprises a solid pellet member. 234. The system of claim 233, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 235) Item 230. The system of item 229, wherein the spring includes a single generally helical shaped coil. (Item 236) Item 230. The system of item 229, wherein the spring includes a plurality of generally helical shaped coils. (Item 237) Item 237. The system of item 236, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 238) Item 237. The system of item 236, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 239) Item 238. The system of item 237, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 240) Item 239. The system of item 238, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 241) Item 225. The system of item 224, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 242) Item 243. The system of item 182, wherein the plunger includes a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 183. The system of item 182, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 244) Item 183. The system of item 182, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 245) Item 245. The system of item 244, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 246) Item 245. The system of item 244, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 247) Item 227. The system of item 226, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 248) Item 183. The system of item 182, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 249) Item 249. The system of item 248, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 250) Item 250. The system of item 249, wherein the damping member comprises a plate aperture damping portion. (Item 251) Item 251. The system of item 250, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 252) Item 251. The system of item 250, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 253) Item 253. The system of item 252, wherein the plate aperture damper is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 254) Item 250. The system of item 249, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 255) Item 255. The system of item 254, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 256) Item 255. The system of item 254, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 257) Item 256. The system of item 255, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 258) Item 257. The system of item 256, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 259) Item 249. The system of item 248, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 260) Item 260. The system of item 259, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 261) Item 183. The system of item 182, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharp distal end of the needle while also aligning the sharp proximal end of the needle for mating with the syringe body upon installation by a user. (Item 262) Item 262. The system of item 261, wherein the needle shield removably couples to the needle by at least one snap-over detent joint. (Item 263) Item 263. The system of item 262, wherein the needle shield removably couples to the needle by at least two snap-over detent joints. (Item 264) Item 264. The system of item 263, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 265) Item 264. The system of item 263, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 266) Item 262. The system of item 261, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 267) Item 183. The system of item 182, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 268) Item 268. The system of item 267, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal medication chamber and the extension member. (Item 269) Item 183. The system of item 182, further comprising an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 270) Item 183. The system of item 182, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 271) Item 271. The system of item 270, wherein the distal end of the needle becomes structurally encapsulated within the internal medication chamber. (Item 272) Item 271. The system of item 270, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 273) 1. A system for injection comprising: a syringe body defining an internal drug chamber and a distal needle junction defining a luer taper; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber, the stopper member having a proximal end and a distal end; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having a proximal end and a distal end, the proximal end connecting to the distal needle interface of the syringe body; The system, wherein the needle proximal end is configured to releasably couple to an outer surface of the Luer taper. (Item 274) Item 274. The system of item 273, wherein the syringe body comprises a commercially available syringe body. (Item 275) Item 276. The system of item 273, wherein the syringe body comprises a generally cylindrical geometry. Item 274. The system of item 273, wherein the medicament chamber is configured to contain about 0.5 cc to about 5 cc of medicament. (Item 277) Item 277. The system of item 276, wherein the medicament chamber is configured to accommodate a volume of medicament selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 278) The system according to item 273, wherein the syringe body comprises a glass material. (Item 279) The system according to item 273, wherein the syringe body comprises a polymer material. (Item 280) The system according to item 279, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 281) The system according to item 273, wherein the syringe body comprises a metal. (Item 282) The system according to item 273, comprising a distal outer geometry configured to be mechanically coupled to one or more other device elements. (Item 283) The system according to item 282, wherein the distal outer geometry of the syringe body comprises a luer lock joint. (Item 284) The system according to item 282, wherein the distal outer geometry of the syringe body comprises a luer taper joint. (Item 285) The system according to item 273, wherein the syringe body defines a distal drug port. (Item 286) The system according to item 285, wherein the needle is selected to have a maximum outer diameter such that it can be inserted through the distal drug port of the syringe body. (Item 287) The system according to item 286, wherein the distal drug port has an inner diameter of about 1 mm. (Item 288) The system according to item 287, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 289) The system according to item 273, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 290) Item 274. The system of item 273, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 291) Item 291. The system of item 290, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 292) Item 274. The system of item 273, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 293) Item 274. The system of item 273, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 294) Item 274. The system of item 273, further comprising a sealant coating applied to at least a portion of the stopper to isolate drug material from the stopper. (Item 295) Item 296. The system of item 294, wherein the sealant coating comprises a PTFE film. Item 274. The system of item 273, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 297) 30. The system of claim 296, wherein the lubricant layer comprises a silicone oil. (Item 298) Item 274. The system of item 273, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 299) 30. The system of claim 298, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 300) Item 274. The system of item 273, wherein the needle comprises at least one radially protruding locking surface feature. (Item 301) Item 301. The system of item 300, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 302) Item 302. The system of item 301, wherein the piercing element comprises a pointed tip. (Item 303) Item 303. The system of item 302, wherein the piercing element comprises a solid structure having no lumen or aperture defined therethrough. (Item 304) Item 302. The system of item 301, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 305) Item 301. The system of item 300, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 306) Item 306. The system of item 305, wherein the cannula member and hub member are formed from the same piece of material. (Item 307) Item 306. The system of item 305, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 308) Item 306. The system of item 305, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form part of the needle. (Item 309) Item 308. The system of item 307, wherein the hub member is formed from a single piece of tubing. (Item 310) Item 306. The system of item 305, wherein the proximal member comprises a piece of flat sheet metal having a proximal linkage joint. (Item 311) Item 309. The system of item 308, wherein the cannula member comprises metal. (Item 312) Item 309. The system of item 308, wherein the hub comprises a metal or plastic material. (Item 313) The proximal member may be made of a metal or plastic material, the system being described in item 308. (Item 314) Item 274. The system of item 273, further comprising an energy storage member operably coupled between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 315) Item 315. The system of item 314, wherein the plunger member comprises a plunger member body defining an interior volume, the energy storage member being housed substantially within the interior volume of the plunger member body. (Item 316) Item 316. The system of item 315, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 317) Item 317. The system of item 316, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 318) Item 318. The system of item 317, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 319) Item 315. The system of item 314, wherein the energy storage member is a spring. (Item 320) Item 319. The system of item 319, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 321) Item 320. The system of item 319, wherein the spring comprises an elastomeric polymer. (Item 322) Item 322. The system of item 321, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 323) Item 324. The system of item 314, wherein the energy storage member comprises a solid pellet member. 324. The system of claim 323, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 325) Item 320. The system of item 319, wherein the spring includes a single generally helical shaped coil. (Item 326) Item 320. The system of item 319, wherein the spring includes a plurality of generally helical shaped coils. (Item 327) Item 327. The system of item 326, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 328) Item 327. The system of item 326, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 329) Item 328. The system of item 327, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 330) Item 330. The system of item 329, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 331) Item 317. The system of item 316, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 332) Item 333. The system of item 273, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 274. The system of item 273, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 334) Item 274. The system of item 273, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 335) Item 335. The system of item 334, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 336) Item 335. The system of item 334, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 337) Item 315. The system of item 314, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 338) Item 274. The system of item 273, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 339) Item 339. The system of item 338, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 340) Item 340. The system of item 339, wherein the damping member comprises a plate aperture damping portion. (Item 341) Item 341. The system of item 340, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 342) Item 341. The system of item 340, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 343) Item 343. The system of item 342, wherein the plate aperture damper is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 344) Item 340. The system of item 339, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 345) Item 345. The system of item 344, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 346) Item 345. The system of item 344, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 347) Item 343. The system of item 342, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 348) Item 347. The system of item 346, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 349) Item 339. The system of item 338, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 350) Item 349. The system of item 349, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 351) Item 274. The system of item 273, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharpened distal end of the needle while also aligning the sharpened proximal end of the needle for mating with the syringe body upon installation by a user. (Item 352) Item 352. The system of item 351, wherein the needle shield removably couples to the needle by at least one snap-over detent joint. (Item 353) Item 353. The system of item 352, wherein the needle shield removably couples to the needle by at least two snap-over detent joints. (Item 354) Item 354. The system of item 353, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 355) Item 354. The system of item 353, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 356) Item 352. The system of item 351, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 357) Item 274. The system of item 273, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 358) Item 358. The system of item 357, further comprising an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal medication chamber and the extension member. (Item 359) Item 274. The system of item 273, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 360) Item 274. The system of item 273, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 361) Item 361. The system of item 360, wherein the distal end of the needle becomes structurally encapsulated within the internal medication chamber. (Item 362) Item 361. The system of item 360, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 363) 1. A system for injection comprising: a syringe body defining an internal medication chamber and a distal needle junction; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having a proximal end and a distal end, the proximal end configured to couple to the stopper member upon retraction of the stopper member to a fully inserted position such that upon retraction of the stopper member, the needle is pulled proximally with the stopper into the internal medicament chamber; A system for preventing the needle from being reinserted out of the internal drug chamber and reinserted therein by being misaligned with the longitudinal axis of the syringe body when the needle is retracted into the internal drug chamber at a position where the distal end of the needle is contained within the internal drug chamber. (Item 364) Item 364. The system of item 363, wherein the needle is configured to plastically deform upon an attempt to reinsert the needle into the syringe body after the needle becomes misaligned with the longitudinal axis of the syringe body. (Item 365) Item 365. The system of item 364, wherein the needle is configured to plastically deform with bending in at least a portion of the needle. (Item 366) Item 364. The system of item 363, wherein the syringe body comprises a commercially available syringe body. (Item 367) Item 368. The system of item 363, wherein the syringe body comprises a generally cylindrical geometry. Item 364. The system of item 363, wherein the medication chamber is configured to contain about 0.5 cc to about 5 cc of medication. (Item 369) Item 369. The system of item 368, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 370) Item 364. The system of item 363, wherein the syringe body comprises a glass material. (Item 371) Item 364. The system of item 363, wherein the syringe body comprises a polymeric material. (Item 372) Item 372. The system of item 371, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 373) Item 364. The system of item 363, wherein the syringe body comprises metal. (Item 374) Item 364. The system of item 363, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 375) Item 375. The system of item 374, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 376) Item 375. The system of item 374, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 377) Item 364. The system of item 363, wherein the syringe body defines a distal drug port. (Item 378) Item 378. The system of item 377, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 379) Item 379. The system of item 378, wherein the distal drug port has an inner diameter of about 1 mm. (Item 380) Item 379. The system of item 379, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 381) Item 364. The system of item 363, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 382) Item 364. The system of item 363, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 383) The system of item 382, wherein the at least one anchor element is selected from the group consisting of a skive cut, a hook geometry, a barb geometry, a corrugated radial geometry, a deformable member configured to be insertable in a relatively small cross-sectional state and deformable to a larger cross-sectional state, and an extended faceted barb configuration. (Item 384) The system of item 363, wherein the stopper has an outer geometry selected to substantially conform to the inner geometry of the syringe body to substantially seal therewith. (Item 385) The system of item 363, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 386) The system of item 363, further comprising a sealant coating applied to at least a portion of the stopper to isolate the pharmaceutical material therefrom. (Item 387) The system of item 386, wherein the sealant coating comprises a PTFE film. (Item 388) The system of item 363, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 389) The system of item 388, wherein the lubricant layer comprises silicone oil. (Item 390) The system of item 363, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 391) The system of item 390, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to the needle. (Item 392) The system of item 363, wherein the needle comprises at least one radially projecting locking surface mechanism. (Item 393) Item 393. The system of item 392, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 394) Item 394. The system of item 393, wherein the piercing element comprises a pointed tip. (Item 395) Item 395. The system of item 394, wherein the piercing element comprises a solid structure having no lumen or aperture defined therethrough. (Item 396) Item 394. The system of item 393, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 397) Item 393. The system of item 392, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 398) Item 398. The system of item 397, wherein the cannula member and hub member are formed from the same piece of material. (Item 399) Item 398. The system of item 397, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 400) Item 398. The system of item 397, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form a portion of the needle. (Item 401) 40. The system of claim 399, wherein the hub member is formed from a single piece of tubing. (Item 402) Item 398. The system of item 397, wherein the proximal member comprises a piece of flat sheet metal having a proximal linkage joint. (Item 403) Item 401. The system of item 400, wherein the cannula member comprises metal. (Item 404) Item 401. The system of item 400, wherein the hub comprises a metal or plastic material. (Item 405) The proximal member may be made of a metal or plastic material, as described in item 400. (Item 406) Item 364. The system of item 363, further comprising an energy storage member operably connected between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 407) Item 407. The system of item 406, wherein the plunger member comprises a plunger member body defining an internal volume, the energy storage member being housed substantially within the internal volume of the plunger member body. (Item 408) Item 408. The system of item 407, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 409) Item 409. The system of item 408, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 410) Item 409. The system of item 409, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 411) Item 407. The system of item 406, wherein the energy storage member is a spring. (Item 412) Item 412. The system of item 411, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 413) Item 412. The system of item 411, wherein the spring comprises an elastomeric polymer. (Item 414) Item 414. The system of item 413, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 415) Item 416. The system of item 406, wherein the energy storage member comprises a solid pellet member. Item 416. The system of item 415, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 417) Item 412. The system of item 411, wherein the spring includes a single generally helical shaped coil. (Item 418) Item 412. The system of item 411, wherein the spring includes a plurality of generally helical shaped coils. (Item 419) Item 419. The system of item 418, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 420) Item 419. The system of item 418, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 421) Item 420. The system of item 419, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 422) Item 422. The system of item 421, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 423) Item 407. The system of item 406, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 424) Item 425. The system of item 363, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 364. The system of item 363, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 426) Item 364. The system of item 363, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 427) Item 427. The system of item 426, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 428) Item 427. The system of item 426, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 429) Item 407. The system of item 406, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 430) Item 364. The system of item 363, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 431) Item 431. The system of item 430, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 432) Item 432. The system of item 431, wherein the damping member comprises a plate aperture damping portion. (Item 433) Item 433. The system of item 432, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 434) Item 433. The system of item 432, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 435) Item 435. The system of item 434, wherein the plate aperture damper is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 436) Item 432. The system of item 431, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 437) Item 437. The system of item 436, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 438) Item 437. The system of item 436, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 439) Item 438. The system of item 437, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 440) Item 439. The system of item 438, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 441) Item 431. The system of item 430, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 442) Item 442. The system of item 441, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 443) Item 364. The system of item 363, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharp distal end of the needle while also aligning the sharp proximal end of the needle for mating with the syringe body upon installation by a user. (Item 444) Item 444. The system of item 443, wherein the needle shield removably couples to the needle by at least one snap-over detent joint. (Item 445) Item 445. The system of item 444, wherein the needle shield removably connects to the needle by at least two snap-over detent joints. (Item 446) Item 446. The system of item 445, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 447) Item 446. The system of item 445, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 448) Item 444. The system of item 443, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 449) Item 364. The system of item 363, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 450) Item 449. The system of item 449, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 451) Item 364. The system of item 363, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain connected to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 452) Item 364. The system of item 363, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 453) Item 453. The system of item 452, wherein the distal end of the needle is structurally encapsulated within the internal medication chamber. (Item 454) Item 453. The system of item 452, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 455) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having a sharp distal end; e. a needle door member movably coupled to the syringe body and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 456) Item 456. The system of item 455, wherein the needle door member defines an aperture therethrough configured to facilitate penetration of the needle when in the first state and configured to be repositioned relative to the syringe body in the second state such that the aperture is misaligned with the longitudinal axis of the needle such that the needle does not penetrate the aperture but is blocked by a non-aperture portion of the door member when insertion of the needle is attempted relative to the needle door member. (Item 457) Item 456. The system of item 455, wherein the needle door member is configured for slidable movement in a plane relative to the longitudinal axis of the needle. (Item 458) Item 458. The system of item 457, wherein the needle door member is configured for slidable movement in a plane that is substantially perpendicular to a longitudinal axis of the needle. (Item 459) Item 456. The system of item 455, wherein the needle door member is configured to rotate relative to a longitudinal axis of the needle. (Item 460) Item 460. The system of item 459, wherein the needle door member is configured to rotate about an axis of rotation that substantially intersects a longitudinal axis of the needle. (Item 461) Item 459. The system of item 459, wherein the needle door member is configured to rotate about an axis of rotation that does not intersect a longitudinal axis of the needle. (Item 462) Item 461. The system of item 460, wherein the needle door member comprises a spherical geometry defining a needle through channel therethrough. (Item 463) Item 456. The system of item 455, wherein the syringe body comprises a commercially available syringe body. (Item 464) Item 465. The system of item 455, wherein the syringe body comprises a generally cylindrical geometry. Item 456. The system of item 455, wherein the medication chamber is configured to contain between about 0.5 cc and about 5 cc of medication. (Item 466) Item 466. The system of item 465, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 467) Item 456. The system of item 455, wherein the syringe body comprises a glass material. (Item 468) Item 456. The system of item 455, wherein the syringe body comprises a polymeric material. (Item 469) Item 469. The system of item 468, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 470) Item 456. The system of item 455, wherein the syringe body comprises metal. (Item 471) Item 456. The system of item 455, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 472) Item 473. The system of item 472, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 473) Item 473. The system of item 472, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 474) Item 456. The system of item 455, wherein the syringe body defines a distal drug port. (Item 475) Item 475. The system of item 474, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 476) Item 476. The system of item 475, wherein the distal drug port has an inner diameter of about 1 mm. (Item 477) Item 476. The system of item 475, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 478) Item 456. The system of item 455, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 479) Item 456. The system of item 455, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 480) Item 479. The system of item 479, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 481) Item 456. The system of item 455, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 482) Item 456. The system of item 455, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 483) Item 456. The system of item 455, further comprising a sealant coating applied to at least a portion of the stopper to isolate drug material from the stopper. (Item 484) Item 484. The system of item 483, wherein the sealant coating comprises a PTFE film. (Item 485) Item 456. The system of item 455, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 486) Item 486. The system of item 485, wherein the lubricant layer comprises a silicone oil. (Item 487) Item 456. The system of item 455, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 488) Item 488. The system of item 487, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 489) Item 456. The system of item 455, wherein the needle comprises at least one radially protruding locking surface feature. (Item 490) Item 489, the system of item 489, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 491) Item 491. The system of item 490, wherein the piercing element comprises a pointed tip. (Item 492) Item 492. The system of item 491, wherein the penetrating element comprises a solid structure having no lumen or aperture defined therethrough. (Item 493) Item 491. The system of item 490, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 494) Item 489. The system of item 489, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 495) Item 495. The system of item 494, wherein the cannula member and hub member are formed from the same piece of material. (Item 496) Item 495. The system of item 494, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 497) Item 495. The system of item 494, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form part of the needle. (Item 498) Item 497. The system of item 496, wherein the hub member is formed from a single piece of tubing. (Item 499) Item 495. The system of item 494, wherein the proximal member comprises a piece of flat sheet metal having a proximal connection joint. (item 500) Item 498. The system of item 497, wherein the cannula member comprises metal. (Item 501) Item 498. The system of item 497, wherein the hub comprises a metal or plastic material. (Item 502) The proximal member may be made of a metal or plastic material, the system being described in item 497. (Item 503) Item 456. The system of item 455, further comprising an energy storage member operably connected between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 504) Item 504. The system of item 503, wherein the plunger member comprises a plunger member body defining an internal volume, the energy storage member being housed substantially within the internal volume of the plunger member body. (Item 505) Item 505. The system of item 504, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 506) Item 506. The system of item 505, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 507) Item 507. The system of item 506, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 508) Item 504. The system of item 503, wherein the energy storage member is a spring. (Item 509) Item 509. The system of item 508, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 510) Item 509. The system of item 508, wherein the spring comprises an elastomeric polymer. (Item 511) 511. The system of claim 510, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 512) Item 513. The system of item 503, wherein the energy storage member comprises a solid pellet member. 513. The system of claim 512, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 514) Item 509. The system of item 508, wherein the spring includes a single generally helical shaped coil. (Item 515) Item 509. The system of item 508, wherein the spring includes a plurality of generally helical shaped coils. (Item 516) Item 516. The system of item 515, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 517) Item 516. The system of item 515, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 518) Item 517. The system of item 516, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 519) Item 519. The system of item 518, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 520) Item 504. The system of item 503, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 521) Item 522. The system of item 455, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 456. The system of item 455, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 523) Item 456. The system of item 455, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 524) Item 524. The system of item 523, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 525) Item 524. The system of item 523, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 526) Item 505. The system of item 504, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 527) Item 456. The system of item 455, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 528) Item 528. The system of item 527, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 529) Item 529. The system of item 528, wherein the damping member comprises a plate aperture damping portion. (Item 530) Item 530. The system of item 529, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 531) Item 530. The system of item 529, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 532) Item 532. The system of item 531, wherein the plate aperture damper is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 533) Item 529. The system of item 528, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 534) Item 534. The system of item 533, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 535) Item 534. The system of item 533, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 536) Item 535. The system of item 534, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 537) Item 536. The system of item 535, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 538) Item 528. The system of item 527, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 539) Item 407. The system of item 406, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 540) Item 456. The system of item 455, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharpened distal end of the needle while also aligning the sharpened proximal end of the needle for mating with the syringe body upon installation by a user. (Item 541) Item 541. The system of item 540, wherein the needle shield removably couples to the needle by at least one snap-over detent joint. (Item 542) Item 542. The system of item 541, wherein the needle shield removably couples to the needle by at least two snap-over detent joints. (Item 543) Item 543. The system of item 542, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 544) Item 543. The system of item 542, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 545) Item 541. The system of item 540, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 546) Item 456. The system of item 455, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 547) Item 547. The system of item 546, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 548) Item 456. The system of item 455, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain connected to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 549) Item 456. The system of item 455, wherein the plunger member is configured to be manually retracted into the second state by an operator. (Item 550) 1. A system for injection comprising: a syringe body defining an internal drug chamber and a distal needle junction defining a luer taper; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber, the stopper member having a proximal end and a distal end; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a medication cap configured to removably couple to the distal needle interface and seal the interior medication chamber; e. a needle having a proximal end and a distal end, the proximal end comprising a coupling portion configured to releasably couple to an outer surface of the luer taper after the drug cap is removed, and a retraction portion configured to couple to the stopper member such that the needle may be retracted relative to the syringe body upon retraction of the stopper member relative to the syringe body; (Item 551) Item 551. The system of item 550, wherein the syringe body comprises a commercially available syringe body. (Item 552) Item 553. The system of item 550, wherein the syringe body comprises a generally cylindrical geometry. Item 551. The system of item 550, wherein the medicament chamber is configured to contain between about 0.5 cc and about 5 cc of medicament. (Item 554) Item 554. The system of item 553, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 555) Item 551. The system of item 550, wherein the syringe body comprises a glass material. (Item 556) Item 551. The system of item 550, wherein the syringe body comprises a polymeric material. (Item 557) Item 557. The system of item 556, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 558) Item 551. The system of item 550, wherein the syringe body comprises a metal. (Item 559) Item 551. The system of item 550, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 560) Item 559, the system of item 559, wherein the distal outer geometry of the syringe body includes a luer lock junction. (Item 561) Item 559, the system of item 559, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 562) The system of item 550, wherein the syringe body defines a distal drug port. (Item 563) Item 563. The system of item 562, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 564) Item 564. The system of item 563, wherein the distal drug port has an inner diameter of about 1 mm. (Item 565) Item 565. The system of item 564, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 566) Item 551. The system of item 550, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 567) Item 551. The system of item 550, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 568) Item 568. The system of item 567, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 569) Item 551. The system of item 550, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 570) Item 551. The system of item 550, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 571) Item 551. The system of item 550, further comprising a sealant coating applied to at least a portion of the stopper to isolate drug material from the stopper. (Item 572) Item 573. The system of item 571, wherein the sealant coating comprises a PTFE film. Item 551. The system of item 550, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 574) Item 574. The system of item 573, wherein the lubricant layer comprises silicone oil. (Item 575) Item 551. The system of item 550, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 576) Item 576. The system of item 575, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 577) Item 551. The system of item 550, wherein the needle comprises at least one radially protruding locking surface feature. (Item 578) Item 578. The system of item 577, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 579) Item 579. The system of item 578, wherein the piercing element comprises a pointed tip. (Item 580) Item 579. The system of item 579, wherein the penetrating element comprises a solid structure having no lumen or aperture defined therethrough. (Item 581) Item 579. The system of item 578, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 582) Item 578. The system of item 577, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 583) Item 583. The system of item 582, wherein the cannula member and hub member are formed from the same piece of material. (Item 584) Item 583. The system of item 582, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 585) Item 583. The system of item 582, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form a portion of the needle. (Item 586) Item 585. The system of item 584, wherein the hub member is formed from a single piece of tubing. (Item 587) Item 585. The system of item 584, wherein the proximal member comprises a piece of flat sheet metal having a proximal linkage joint. (Item 588) Item 586. The system of item 585, wherein the cannula member comprises metal. (Item 589) Item 586. The system of item 585, wherein the hub comprises a metal or plastic material. (Item 590) The proximal member may be made of a metal or plastic material, the system being described in item 585. (Item 591) Item 551. The system of item 550, further comprising an energy storage member operably coupled between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 592) Item 592. The system of item 591, wherein the plunger member comprises a plunger member body defining an internal volume, the energy storage member being housed substantially within the internal volume of the plunger member body. (Item 593) Item 593. The system of item 592, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 594) Item 594. The system of item 593, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 595) Item 595. The system of item 594, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 596) Item 592. The system of item 591, wherein the energy storage member is a spring. (Item 597) Item 597. The system of item 596, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 598) Item 597. The system of item 596, wherein the spring comprises an elastomeric polymer. (Item 599) 599. The system of claim 598, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 600) Item 601. The system of item 591, wherein the energy storage member comprises a solid pellet member. Item 601. The system of item 600, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 602) Item 597. The system of item 596, wherein the spring includes a single generally helical shaped coil. (Item 603) Item 70. The system of item 596, wherein the spring includes a plurality of generally helical shaped coils. (Item 604) Item 604. The system of item 603, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 605) Item 604. The system of item 603, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 606) Item 605. The system of item 604, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 607) Item 607. The system of item 606, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 608) Item 592. The system of item 591, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 609) Item 610: The system of item 550, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 551. The system of item 550, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 611) Item 551. The system of item 550, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 612) Item 612. The system of item 611, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 613) Item 612. The system of item 611, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 614) Item 594. The system of item 593, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 615) Item 551. The system of item 550, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 616) Item 616. The system of item 615, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 617) Item 617. The system of item 616, wherein the damping member comprises a plate aperture damping portion. (Item 618) Item 618. The system of item 617, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 619) Item 618. The system of item 617, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 620) Item 620. The system of item 619, wherein the plate aperture damping portion is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 621) Item 617. The system of item 616, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 622) Item 622. The system of item 621, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 623) Item 622. The system of item 621, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 624) Item 623. The system of item 622, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 625) Item 624. The system of item 623, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 626) Item 616. The system of item 615, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 627) Item 627. The system of item 626, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 628) Item 551. The system of item 550, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharpened distal end of the needle while also aligning the sharpened proximal end of the needle for mating with the syringe body upon installation by a user. (Item 629) Item 629. The system of item 628, wherein the needle shield removably couples to the needle by at least one snap-over detent joint. (Item 630) Item 629. The system of item 629, wherein the needle shield removably connects to the needle by at least two snap-over detent joints. (Item 631) Item 631. The system of item 630, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 632) Item 631. The system of item 630, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 633) Item 629. The system of item 628, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 634) Item 551. The system of item 550, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 635) Item 635. The system of item 634, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 636) Item 551. The system of item 550, further comprising an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 637) Item 551. The system of item 550, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 638) Item 638. The system of item 637, wherein the distal end of the needle is structurally encapsulated within the internal medication chamber. (Item 639) Item 638. The system of item 637, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body, and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 640) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having sharp proximal and distal ends; e. a needle shield defining an interior volume configured to temporarily house and protect at least the sharpened distal end of the needle while also aligning the sharpened proximal end of the needle for mating with the syringe body upon installation by a user. (Item 641) Item 641. The system of item 640, wherein the syringe body comprises a commercially available syringe body. (Item 642) Item 643. The system of item 640, wherein the syringe body comprises a generally cylindrical geometry. Item 641. The system of item 640, wherein the medication chamber is configured to contain between about 0.5 cc and about 5 cc of medication. (Item 644) Item 644. The system of item 643, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 645) Item 641. The system of item 640, wherein the syringe body comprises a glass material. (Item 646) The system of item 640, wherein the syringe body comprises a polymeric material. (Item 647) Item 647. The system of item 646, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 648) Item 641. The system of item 640, wherein the syringe body comprises a metal. (Item 649) Item 641. The system of item 640, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 650) Item 649. The system of item 649, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 651) Item 649, the system of item 649, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 652) The system of item 640, wherein the syringe body defines a distal drug port. (Item 653) Item 653. The system of item 652, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 654) The system of item 653, wherein the distal drug port has an inner diameter of about 1 mm. (Item 655) Item 655. The system of item 654, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 656) Item 641. The system of item 640, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 657) Item 641. The system of item 640, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 658) Item 658. The system of item 657, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 659) Item 641. The system of item 640, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 660) Item 641. The system of item 640, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 661) Item 641. The system of item 640, further comprising a sealant coating applied to at least a portion of the stopper to isolate a drug material from the stopper. (Item 662) Item 663. The system of item 661, wherein the sealant coating comprises a PTFE film. Item 641. The system of item 640, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 664) Item 664. The system of item 663, wherein the lubricant layer comprises silicone oil. (Item 665) Item 641. The system of item 640, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 666) Item 666. The system of item 665, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 667) Item 641. The system of item 640, wherein the needle comprises at least one radially protruding locking surface feature. (Item 668) Item 668. The system of item 667, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 669) Item 669. The system of item 668, wherein the piercing element comprises a pointed tip. (Item 670) Item 669. The system of item 669, wherein the penetrating element comprises a solid structure having no lumen or aperture defined therethrough. (Item 671) Item 669. The system of item 668, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 672) Item 668. The system of item 667, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 673) Item 673. The system of item 672, wherein the cannula member and hub member are formed from the same piece of material. (Item 674) Item 673. The system of item 672, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 675) Item 673. The system of item 672, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form part of the needle. (Item 676) Item 675. The system of item 674, wherein the hub member is formed from a single piece of tubing. (Item 677) Item 673. The system of item 672, wherein the proximal member comprises a piece of flat sheet metal having a proximal connection joint. (Item 678) Item 677. The system of item 676, wherein the cannula member comprises metal. (Item 679) Item 677. The system of item 676, wherein the hub comprises a metal or plastic material. (Item 680) The proximal member may be made of a metal or plastic material, the system being described in item 676. (Item 681) Item 641. The system of item 640, further comprising an energy storage member operably connected between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 682) Item 682. The system of item 681, wherein the plunger member comprises a plunger member body defining an internal volume, the energy storage member being housed substantially within the internal volume of the plunger member body. (Item 683) Item 683. The system of item 682, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 684) Item 684. The system of item 683, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 685) Item 685. The system of item 684, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 686) Item 682. The system of item 681, wherein the energy storage member is a spring. (Item 687) Item 687. The system of item 686, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 688) Item 687. The system of item 686, wherein the spring comprises an elastomeric polymer. (Item 689) Item 687. The system of item 686, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 690) Item 691. The system of item 681, wherein the energy storage member comprises a solid pellet member. 691. The system of claim 690, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 692) Item 687. The system of item 686, wherein the spring includes a single generally helical shaped coil. (Item 693) Item 687. The system of item 686, wherein the spring includes a plurality of generally helical shaped coils. (Item 694) Item 694. The system of item 693, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 695) Item 694. The system of item 693, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 696) Item 695. The system of item 694, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 697) Item 697. The system of item 696, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 698) Item 682. The system of item 681, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 699) Item 700 is a system according to item 640, wherein the plunger includes a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 641. The system of item 640, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 701) Item 641. The system of item 640, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 702) Item 702. The system of item 701, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member relative to the syringe body. (Item 703) Item 702. The system of item 701, further comprising a locking member operably coupled between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 704) Item 684. The system of item 683, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 705) Item 641. The system of item 640, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 706) Item 706. The system of item 705, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 707) Item 707. The system of item 706, wherein the damping member comprises a plate aperture damping portion. (Item 708) Item 708. The system of item 707, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 709) Item 708. The system of item 707, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 710) Item 709. The system of item 709, wherein the plate aperture damper is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 711) Item 707. The system of item 706, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 712) Item 712. The system of item 711, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 713) Item 712. The system of item 711, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 714) Item 713. The system of item 712, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 715) Item 714. The system of item 713, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 716) Item 706. The system of item 705, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 717) Item 717. The system of item 716, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is withdrawn into the internal drug chamber of the syringe body. (Item 718) Item 641. The system of item 640, wherein the needle shield removably couples to the needle by at least one snap-over detent joint. (Item 719) Item 719. The system of item 718, wherein the needle shield removably couples to the needle by at least two snap-over detent joints. (Item 720) Item 719. The system of item 719, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 721) The system according to item 719, wherein the snap-over return stop joint is oriented to prevent axial movement of the needle covering member relative to the needle until the return stop is mechanically overcome by an axial load. (Item 722) The system according to item 640, comprising a plurality of inwardly radial projecting surfaces, wherein the internal volume of the needle covering member is configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and the syringe body are manually interconnected. (Item 723) The system according to item 640, wherein the drug chamber is defined by the length of the chamber and the needle is defined by a needle length that is greater than or equal to the length of the chamber. (Item 724) The system according to item 723, further comprising an extension member connected to the proximal end of the syringe body, the extension member being operably connected to the plunger member and configured to receive at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 725) The system according to item 640, further comprising an extension member connected to the proximal end of the syringe body, the extension member being operably connected to the plunger member and configured to receive the stopper member when the stopper is retracted to the extent that it at least partially exits the internal drug chamber, the extension member comprising a fluid receiving surface positioned directly adjacent to the distal surface during retraction of the stopper member into the extension chamber of the stopper member, the fluid receiving surface being configured to receive residual droplets of the drug and remaining connected to the distal surface of the stopper member until they are received by the fluid receiving surface. (Item 726) The system according to item 640, wherein the plunger member is configured to be manually stored by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 727) Item 727. The system of item 726, wherein the distal end of the needle is structurally encapsulated within the internal medication chamber. (Item 728) Item 727. The system of item 726, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 729) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having sharp proximal and distal ends; e. A needle shield defining an interior volume configured to temporarily house and protect at least the sharpened distal end of the needle, the needle shield being removably connectable to the needle by at least one snap-over detent joint. (Item 730) Item 729, the system comprising a syringe body comprising a commercially available syringe body. (Item 731) Item 732. The system of item 729, wherein the syringe body comprises a generally cylindrical geometry. Item 729. The system of item 729, wherein the medication chamber is configured to contain about 0.5 cc to about 5 cc of medication. (Item 733) Item 733. The system of item 732, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 734) Item 729. The system of item 729, wherein the syringe body comprises a glass material. (Item 735) Item 729, the system comprising the syringe body comprising a polymeric material. (Item 736) Item 736. The system of item 735, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 737) Item 729. The system of item 729, wherein the syringe body comprises a metal. (Item 738) Item 729, the system comprising: a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 739) Item 739. The system of item 738, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 740) Item 739. The system of item 738, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 741) The system of item 729, wherein the syringe body defines a distal drug port. (Item 742) Item 742. The system of item 741, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 743) The system of item 742, wherein the distal drug port has an inner diameter of about 1 mm. (Item 744) Item 744. The system of item 743, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 745) Item 730. The system of item 729, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 746) Item 730. The system of item 729, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 747) Item 747. The system of item 746, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 748) Item 729. The system of item 729, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 749) Item 729. The system of item 729, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 750) Item 730. The system of item 729, further comprising a sealant coating applied to at least a portion of the stopper to isolate drug material from the stopper. (Item 751) Item 752. The system of item 750, wherein the sealant coating comprises a PTFE film. Item 729. The system of item 729, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 753) Item 753. The system of item 752, wherein the lubricant layer comprises a silicone oil. (Item 754) Item 729. The system of item 729, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 755) Item 755. The system of item 754, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 756) Item 730. The system of item 729, wherein the needle comprises at least one radially protruding locking surface feature. (Item 757) Item 757. The system of item 756, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 758) Item 758. The system of item 757, wherein the piercing element comprises a pointed tip. (Item 759) Item 759. The system of item 758, wherein the penetrating element comprises a solid structure having no lumen or aperture defined therethrough. (Item 760) Item 758. The system of item 757, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 761) Item 757. The system of item 756, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 762) Item 762. The system of item 761, wherein the cannula member and hub member are formed from the same piece of material. (Item 763) Item 762. The system of item 761, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 764) Item 762. The system of item 761, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form a portion of the needle. (Item 765) Item 764. The system of item 763, wherein the hub member is formed from a single piece of tubing. (Item 766) Item 762. The system of item 761, wherein the proximal member comprises a piece of flat sheet metal having a proximal connection joint. (Item 767) Item 765. The system of item 764, wherein the cannula member comprises metal. (Item 768) Item 765. The system of item 764, wherein the hub comprises a metal or plastic material. (Item 769) The proximal member may be made of a metal or plastic material, the system being described in item 764. (Item 770) Item 729. The system of item 729, further comprising an energy storage member operably coupled between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 771) Item 771. The system of item 770, wherein the plunger member comprises a plunger member body defining an interior volume, the energy storage member being housed substantially within the interior volume of the plunger member body. (Item 772) Item 772. The system of item 771, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 773) Item 773. The system of item 772, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 774) Item 774. The system of item 773, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 775) Item 771. The system of item 770, wherein the energy storage member is a spring. (Item 776) Item 776. The system of item 775, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 777) Item 776. The system of item 775, wherein the spring comprises an elastomeric polymer. (Item 778) 771. The system of claim 770, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 779) Item 780. The system of item 770, wherein the energy storage member comprises a solid pellet member. 78. The system of claim 779, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 781) Item 776. The system of item 775, wherein the spring includes a single generally helical shaped coil. (Item 782) Item 776. The system of item 775, wherein the spring includes a plurality of generally helical shaped coils. (Item 783) Item 783. The system of item 782, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 784) Item 783. The system of item 782, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 785) Item 517. The system of item 516, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 786) Item 786. The system of item 785, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 787) Item 771. The system of item 770, wherein retraction of the plunger retracts the interconnected stopper member and needle such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 788) Item 789. The system of item 729, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 729 is a system according to item 729, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and to couple to the stopper member by such insertion. (Item 790) Item 729. The system of item 729, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 791) Item 791. The system of item 790, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member relative to the syringe body. (Item 792) 791. The system of claim 790, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 793) Item 773. The system of item 772, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 794) Item 729. The system of item 729, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 795) Item 795. The system of item 794, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 796) Item 796. The system of item 795, wherein the damping member comprises a plate aperture damping portion. (Item 797) Item 797. The system of item 796, wherein the plate aperture stopper comprises a piece of sheet metal having an aperture formed therethrough. (Item 798) Item 797. The system of item 796, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 799) Item 799. The system of item 798, wherein the plate aperture damping portion is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (item 800) Item 796. The system of item 795, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 801) Item 801. The system of item 800, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 802) Item 8. The system of item 800, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 803) Item 802. The system of item 801, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 804) Item 803. The system of item 802, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 805) Item 795. The system of item 794, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 806) Item 806. The system of item 805, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 807) Item 729. The system of item 729, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharp distal end of the needle while also aligning the sharp proximal end of the needle for mating with the syringe body upon installation by a user. (Item 808) Item 729 is a system according to item 729, wherein the needle shield removably connects to the needle by at least two snap-over detent joints. (Item 809) Item 809. The system of item 808, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 810) Item 809. The system of item 808, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 811) Item 808. The system of item 807, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 812) Item 729. The system of item 729, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 813) Item 813. The system of item 812, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 814) Item 729. The system of item 729, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 815) Item 729. The system of item 729, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 816) Item 816. The system of item 815, wherein the distal end of the needle is structurally encapsulated within the internal medication chamber. (Item 817) Item 816. The system of item 815, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 818) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. A system comprising: a needle having proximal and distal ends and an air bubble exhaust lumen defined therebetween, the air bubble exhaust lumen comprising an inlet port defined into the needle and positioned directly adjacent the distal end of the drug chamber such that air bubbles within the drug chamber may be released by insertion of the stopper member regardless of the degree to which the proximal end of the needle protrudes into the drug chamber. (Item 819) Item 819. The system of item 818, wherein the syringe body comprises a commercially available syringe body. (Item 820) Item 821. The system of item 818, wherein the syringe body comprises a generally cylindrical geometry. Item 819. The system of item 818, wherein the medication chamber is configured to contain between about 0.5 cc and about 5 cc of medication. (Item 822) Item 822. The system of item 821, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 823) Item 819. The system of item 818, wherein the syringe body comprises a glass material. (Item 824) Item 819. The system of item 818, wherein the syringe body comprises a polymeric material. (Item 825) 825. The system of claim 824, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 826) Item 819. The system of item 818, wherein the syringe body comprises metal. (Item 827) Item 819. The system of item 818, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 828) Item 827. The system of item 827, wherein the distal outer geometry of the syringe body includes a luer lock junction. (Item 829) Item 828. The system of item 827, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 830) The system of item 818, wherein the syringe body defines a distal drug port. (Item 831) Item 831. The system of item 830, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 832) The system of item 831, wherein the distal drug port has an inner diameter of about 1 mm. (Item 833) Item 833. The system of item 832, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 834) Item 819. The system of item 818, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 835) Item 819. The system of item 818, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 836) Item 836. The system of item 835, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 837) Item 819. The system of item 818, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 838) Item 819. The system of item 818, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 839) Item 819. The system of item 818, further comprising a sealant coating applied to at least a portion of the stopper to isolate a drug material from the stopper. (Item 840) Item 841. The system of item 839, wherein the sealant coating comprises a PTFE film. Item 819. The system of item 818, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 842) Item 842. The system of item 841, wherein the lubricant layer comprises silicone oil. (Item 843) Item 819. The system of item 818, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 844) Item 844. The system of item 843, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 845) Item 819. The system of item 818, wherein the needle comprises at least one radially protruding locking surface feature. (Item 846) Item 846. The system of item 845, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 847) Item 847. The system of item 846, wherein the piercing element comprises a pointed tip. (Item 848) Item 848. The system of item 847, wherein the penetrating element comprises a solid structure having no lumen or aperture defined therethrough. (Item 849) Item 847. The system of item 846, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 850) Item 846. The system of item 845, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 851) Item 851. The system of item 850, wherein the cannula member and hub member are formed from the same piece of material. (Item 852) Item 851. The system of item 850, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 853) Item 851. The system of item 850, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form a portion of the needle. (Item 854) Item 853. The system of item 852, wherein the hub member is formed from a single piece of tubing. (Item 855) Item 851. The system of item 850, wherein the proximal member comprises a piece of flat sheet metal having a proximal linkage joint. (Item 856) Item 854. The system of item 853, wherein the cannula member comprises metal. (Item 857) Item 854. The system of item 853, wherein the hub comprises a metal or plastic material. (Item 858) The proximal member may be made of a metal or plastic material, the system being described in item 853. (Item 859) Item 819. The system of item 818, further comprising an energy storage member operably connected between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 860) Item 859. The system of item 859, wherein the plunger member comprises a plunger member body defining an internal volume, the energy storage member being housed substantially within the internal volume of the plunger member body. (Item 861) Item 860. The system of item 860, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 862) Item 862. The system of item 861, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 863) Item 863. The system of item 862, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 864) Item 859. The system of item 859, wherein the energy storage member is a spring. (Item 865) Item 865. The system of item 864, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 866) Item 865. The system of item 864, wherein the spring comprises an elastomeric polymer. (Item 867) 867. The system of claim 866, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 868) Item 869. The system of item 859, wherein the energy storage member comprises a solid pellet member. 869. The system of claim 868, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 870) Item 865. The system of item 864, wherein the spring includes a single generally helical shaped coil. (Item 871) Item 865. The system of item 864, wherein the spring includes a plurality of generally helical shaped coils. (Item 872) Item 872. The system of item 871, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 873) Item 872. The system of item 871, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 874) Item 873. The system of item 872, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 875) Item 875. The system of item 874, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 876) Item 859. The system of item 859, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 877) Item 878. The system of item 818, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 819. The system of item 818, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 879) Item 819. The system of item 818, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 880) Item 879. The system of item 879, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member relative to the syringe body. (Item 881) Item 879. The system of item 879, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 882) Item 862. The system of item 861, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 883) Item 819. The system of item 818, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 884) Item 883. The system of item 883, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 885) Item 885. The system of item 884, wherein the damping member comprises a plate aperture damping portion. (Item 886) Item 886. The system of item 885, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 887) Item 885. The system of item 885, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 888) Item 888. The system of item 887, wherein the plate aperture damping portion is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 889) Item 885. The system of item 884, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 890) Item 889. The system of item 889, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 891) Item 889. The system of item 889, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 892) Item 891. The system of item 890, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 893) Item 892. The system of item 891, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 894) Item 884. The system of item 883, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 895) Item 895. The system of item 894, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 896) Item 819. The system of item 818, further comprising a needle shield defining an interior volume configured to temporarily house and protect at least the sharp distal end of the needle while also aligning the sharp proximal end of the needle for mating with the syringe body upon installation by a user. (Item 897) Item 897. The system of item 896, wherein the needle shield removably connects to the needle by at least one snap-over detent joint. (Item 898) Item 898. The system of item 897, wherein the needle shield removably connects to the needle by at least two snap-over detent joints. (Item 899) Item 899. The system of item 898, wherein a snap-over detent joint is oriented to prevent rotation of the needle shield about an axis substantially aligned with the axis of the needle until the detent is mechanically overcome by a torsional load. (Item 900) Item 899. The system of item 898, wherein a snap-over detent joint is oriented to prevent axial movement of the needle shield relative to the needle until the detent is mechanically overcome by an axial load. (Item 901) Item 897. The system of item 896, wherein the interior volume of the needle shield comprises a plurality of inwardly radially protruding surfaces configured to guide the pointed proximal end of the needle relative to the syringe body when the needle and syringe body are manually interconnected. (Item 902) Item 819. The system of item 818, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 903) Item 903. The system of item 902, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 904) Item 819. The system of item 818, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain connected to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 905) Item 819. The system of item 818, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 906) Item 906. The system of item 905, wherein the distal end of the needle is structurally encapsulated within the internal medication chamber. (Item 907) Item 906. The system of item 905, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 908) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having sharp proximal and distal ends; e. a distal sealing element having a proximal end and a distal end, sealably disposed within the medicament chamber, the distal sealing element releasably coupling to the needle proximal end such that a sealed joint is provided therebetween; in a first coupling mode, the pointed proximal end of the needle is positioned at least partially through the distal sealing element such that the distal sealing element grips the needle proximal end; In a second release mode, an expansion element expands the junction between the distal sealing element and the pointed end of the needle such that the needle is releasable from the distal sealing element. (Item 909) Item 909. The system of item 908, wherein the sharpened needle proximal end is coupled to the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper and at least partially contained within the internal medication chamber. (Item 910) Item 909 is a system according to item 909, wherein the pointed needle proximal end comprises an anchor geometry configured to be at least partially inserted into the stopper member. (Item 911) The system of item 908, wherein the syringe body comprises a commercially available syringe body. (Item 912) Item 913. The system of item 908, wherein the syringe body comprises a generally cylindrical geometry. Item 909. The system of item 908, wherein the medication chamber is configured to contain between about 0.5 cc and about 5 cc of medication. (Item 914) Item 914. The system of item 913, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 915) Item 909. The system of item 908, wherein the syringe body comprises a glass material. (Item 916) The system of item 908, wherein the syringe body comprises a polymeric material. (Item 917) Item 917. The system of item 916, wherein the polymer material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 918) Item 919. The system of item 918, wherein the syringe body comprises metal. (Item 919) The system of item 908, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 920) Item 920. The system of item 919, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 921) Item 920. The system of item 919, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 922) The system of item 908, wherein the syringe body defines a distal drug port. (Item 923) Item 923. The system of item 922, wherein the needle has a maximum outer diameter selected to be insertable through the distal drug port of the syringe body. (Item 924) The system of item 923, wherein the distal drug port has an inner diameter of about 1 mm. (Item 925) Item 925. The system of item 924, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 926) Item 909. The system of item 908, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 927) Item 909. The system of item 908, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 928) Item 928. The system of item 927, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 929) Item 909. The system of item 908, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 930) Item 909. The system of item 908, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 931) Item 909. The system of item 908, further comprising a sealant coating applied to at least a portion of the stopper to isolate a drug material from the stopper. (Item 932) Item 933. The system of item 931, wherein the sealant coating comprises a PTFE film. Item 909. The system of item 908, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 934) Item 934. The system of item 933, wherein the lubricant layer comprises silicone oil. (Item 935) The system of item 908, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 936) Item 936. The system of item 935, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 937) Item 909. The system of item 908, wherein the needle comprises at least one radially protruding locking surface feature. (Item 938) Item 938. The system of item 937, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 939) Item 939. The system of item 938, wherein the piercing element comprises a pointed tip. (Item 940) Item 939. The system of item 938, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 941) Item 938. The system of item 937, wherein the needle comprises a cannula member and a hub member. (Item 942) Item 942. The system of item 941, wherein the cannula member and hub member are formed from the same piece of material. (Item 943) Item 942. The system of item 941, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 944) Item 942. The system of item 941, wherein the cannula member protrudes axially at a location proximal to the location of the hub member to form a sealing surface configured to mate against the distal sealing element. (Item 945) Item 944. The system of item 943, wherein the hub member is formed from a single piece of tubing. (Item 946) The system of item 944, wherein the cannula member comprises metal. (Item 947) Item 945. The system of item 944, wherein the hub comprises a metal or plastic material. (Item 948) Item 909. The system of item 908, further comprising an energy storage member operably connected between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 949) Item 949. The system of item 948, wherein the plunger member comprises a plunger member body defining an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 950) Item 949. The system of item 949, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 951) Item 951. The system of item 950, wherein the locking member comprises a trigger portion extending outside the internal volume of the plunger member body and operably coupled to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 952) Item 952. The system of item 951, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 953) Item 949. The system of item 949, wherein the energy storage member is a spring. (Item 954) Item 954. The system of item 953, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 955) Item 954. The system of item 953, wherein the spring comprises an elastomeric polymer. (Item 956) Item 956. The system of item 955, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 957) Item 958. The system of item 948, wherein the energy storage member comprises a solid pellet member. Item 958. The system of item 957, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 959) Item 954. The system of item 953, wherein the spring includes a single generally helical shaped coil. (Item 960) Item 954. The system of item 953, wherein the spring includes a plurality of generally helical shaped coils. (Item 961) Item 961. The system of item 960, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 962) Item 961. The system of item 960, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 963) Item 962. The system of item 961, wherein the coaxially aligned spiral-shaped coils are also aligned parallel to the longitudinal direction. (Item 964) Item 964. The system of item 963, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 965) Item 949. The system of item 948, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 966) Item 967. The system of item 908, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 909. The system of item 908, wherein the plunger comprises a plunger distal end threaded joint configured to be spirally inserted into the stopper member and to couple to the stopper member upon such insertion. (Item 968) Item 909. The system of item 908, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 969) Item 969. The system of item 968, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 970) Item 969. The system of item 968, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 971) Item 951. The system of item 950, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 972) Item 909. The system of item 908, further comprising a proximal seal configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 973) Item 973. The system of item 972, further comprising a brake member operably coupled to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member relative to the syringe body but resist retraction of the plunger member relative to the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 974) Item 974. The system of item 973, wherein the damping member comprises a plate aperture damping portion. (Item 975) Item 975. The system of item 974, wherein the plate aperture stop comprises a piece of sheet metal having an aperture formed therethrough. (Item 976) Item 975. The system of item 974, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 977) Item 977. The system of item 976, wherein the plate aperture damping portion is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 978) Item 974. The system of item 973, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 979) Item 979. The system of item 978, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 980) Item 979. The system of item 978, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 981) Item 979. The system of item 979, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 982) Item 981. The system of item 980, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 983) Item 973. The system of item 972, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 984) Item 984. The system of item 983, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 985) Item 909. The system of item 908, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 986) Item 985. The system of item 985, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to store at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 987) Item 909. The system of item 908, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of medicament and remain connected to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 988) Item 909. The system of item 908, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 989) Item 989. The system of item 988, wherein the distal end of the needle is structurally encapsulated within the internal medication chamber. (Item 990) Item 989. The system of item 988, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body, and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 991) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having sharp proximal and distal ends; e. a distal sealing element configured to removably couple around at least a portion of the proximal end of the needle and to grip the proximal end of the needle until extended therefrom; and f. an expansion element coupled to the needle proximal end and configured to expand the distal sealing element away from the proximal end of the needle to release the needle from the distal sealing element by advancement of the distal sealing element towards the expansion element, while the expansion element and interconnected needle remain substantially immobile relative to the syringe body. (Item 992) Item 992. The system of item 991, wherein the sharpened needle proximal end is coupled to the stopper member such that upon retraction of the stopper member, the needle is pulled proximally along with the stopper and at least partially contained within the internal medication chamber. (Item 993) Item 993. The system of item 992, wherein the pointed needle proximal end comprises an anchor geometry configured to be at least partially inserted into the stopper member. (Item 994) Item 992. The system of item 991, wherein the syringe body comprises a commercially available syringe body. (Item 995) Item 996. The system of item 991, wherein the syringe body comprises a generally cylindrical geometry. Item 992. The system of item 991, wherein the medication chamber is configured to contain between about 0.5 cc and about 5 cc of medication. (Item 997) Item 997. The system of item 996, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 998) Item 992. The system of item 991, wherein the syringe body comprises a glass material. (Item 999) Item 992. The system of item 991, wherein the syringe body comprises a polymeric material. (item 1000) Item 999. The system of item 999, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1001) Item 992. The system of item 991, wherein the syringe body comprises metal. (Item 1002) Item 992. The system of item 991, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 1003) The system of item 1002, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 1004) The system of item 1002, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 1005) The system of item 991, wherein the syringe body defines a distal drug port. (Item 1006) Item 1006. The system of item 1005, wherein the needle has a maximum outer diameter selected so as to be insertable through the distal drug port of the syringe body. (Item 1007) The system of item 1006, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 1008) Item 1007, the system according to item 1007, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 1009) Item 992. The system of item 991, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 1010) Item 992. The system of item 991, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 1011) Item 1011. The system of item 1010, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 1012) Item 992. The system of item 991, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 1013) Item 992. The system of item 991, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1014) Item 992. The system of item 991, further comprising a sealant coating applied to at least a portion of the stopper to isolate drug material from the stopper. (Item 1015) Item 1015. The system of item 1014, wherein the sealant coating comprises a PTFE film. (Item 1016) Item 992. The system of item 991, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 1017) Item 1016, the system of item 1016, wherein the lubricant layer comprises silicone oil. (Item 1018) Item 992. The system of item 991, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 1019) Item 1019. The system of item 1018, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 1020) Item 992. The system of item 991, wherein the needle comprises at least one radially protruding locking surface feature. (Item 1021) Item 1021. The system of item 1020, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 1022) Item 1022. The system of item 1021, wherein the piercing element comprises a pointed tip. (Item 1023) Item 1022. The system of item 1021, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 1024) Item 1021. The system of item 1020, wherein the needle comprises a cannula member and a hub member. (Item 1025) Item 1025. The system of item 1024, wherein the cannula member and hub member are formed from the same piece of material. (Item 1026) Item 1025. The system of item 1024, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 1027) Item 1025, the system of item 1024, wherein the cannula member protrudes axially at a location proximal to the location of the hub member to form a sealing surface configured to mate against the distal sealing element. [The sealing portion seals against the needle and not the hub, whereas in the prior art, the sealing portion seals against the hub.] (Item 1028) Item 1026. The system of item 1025, wherein the hub member is formed from a single piece of tubing. (Item 1029) The system of claim 1027, wherein the cannula member comprises metal. (Item 1030) Item 1027. The system of item 1027, wherein the hub comprises a metal or plastic material. (Item 1031) Item 991. The system of item 991, further comprising an energy storage member operably connected between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 1032) Item 1032. The system of item 1031, wherein the plunger member comprises a plunger member body defining an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 1033) Item 1033. The system of item 1032, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 1034) The system described in item 1033, wherein the locking member includes a trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 1035) Item 1035. The system of item 1034, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 1036) Item 1032. The system of item 1031, wherein the energy storage member is a spring. (Item 1037) Item 1037. The system of item 1036, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 1038) Item 1037. The system of item 1036, wherein the spring comprises an elastomeric polymer. (Item 1039) Item 1039. The system of item 1038, wherein the elastomeric polymer is selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 1040) Item 1032. The system of item 1031, wherein the energy storage member comprises a solid pellet member. (Item 1041) Item 1041. The system of item 1040, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 1042) Item 1043. The system of item 1036, wherein the spring includes a single generally helical shaped coil. Item 1044. The system of item 1036, wherein the spring includes a plurality of generally helical shaped coils. Item 1044. The system of item 1043, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 1045) Item 1044. The system of item 1043, wherein at least two of the coils comprising the plurality of generally helical shaped coils are aligned longitudinally parallel. (Item 1046) Item 1046. The system of item 1045, wherein the coaxially aligned spiral-shaped coils are also aligned parallel to the longitudinal direction. (Item 1047) Item 1047. The system of item 1046, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 1048) Item 1032. The system of item 1031, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 1049) Item 1050 is a system according to item 991, wherein the plunger includes a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. Item 992. The system of item 991, wherein the plunger comprises a plunger distal end threaded joint configured to be spirally inserted into the stopper member and to couple to the stopper member upon such insertion. (Item 1051) Item 992. The system of item 991, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member is initially inserted into a predetermined position relative to the syringe body. (Item 1052) Item 1052. The system of item 1051, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 1053) The system described in item 1051, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 1054) Item 1034. The system of item 1033, further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 1055) Item 992. The system of item 991, further comprising a proximal sealing portion configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 1056) The system described in item 1055, further comprising a brake member operably connected to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member into the syringe body but resist retraction of the plunger member into the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 1057) Item 1057. The system of item 1056, wherein the damping member comprises a plate aperture damping portion. (Item 1058) Item 1058. The system of item 1057, wherein the plate aperture stopper comprises a piece of sheet metal having an aperture formed therethrough. (Item 1059) Item 1058. The system of item 1057, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 1060) Item 1059. The system of item 1059, wherein the plate aperture damping portion is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 1061) Item 1057. The system of item 1056, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 1062) Item 1062. The system of item 1061, wherein the storage start load is applied by a spring member operably connected to the brake member. (Item 1063) Item 1062. The system of item 1061, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 1064) Item 1063. The system of item 1062, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 1065) Item 1064. The system of item 1063, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 1066) Item 1057. The system of item 1056, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 1067) Item 1067. The system of item 1066, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 1068) Item 992. The system of item 991, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 1069) Item 1069. The system of item 1068, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 1070) Item 991. The system of item 991, further comprising an extension member connected to the proximal end of the syringe body, the extension member operably connected to the plunger member and configured to accommodate the stopper member when it is retracted to the extent that it at least partially exits the internal drug chamber, the extension member comprising a fluid containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid containing surface configured to accommodate residual droplets of drug and remain connected to the distal surface of the stopper member until they are accommodated by the fluid containing surface. (Item 1071) Item 992. The system of item 991, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 1072) 104. The system of item 1071, wherein the distal end of the needle becomes structurally encapsulated within the internal medication chamber. (Item 1073) Item 1072. The system of item 1071, wherein the distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. (Item 1074) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having a proximal end and a distal end, the proximal end connecting to the distal end of the syringe body; e. a needle sheath operably coupled to the syringe body and defining a lumen through which at least the distal end of the needle may pass, the needle sheath configured to have a first state in which the needle sheath is compressed toward the proximal end of the needle to expose the distal end of the needle for injection, and a second state in which the needle sheath advances forward over the needle distal end to substantially cover the needle and prevent contact with the distal end of the needle; wherein in the first state, in the absence of a sheath retaining element to hold the needle sheath in the first position until the stopper member is advanced to a predetermined position relative to the syringe body, an energy storage member is compressed to bias the needle sheath to spring forward to the second state. (Item 1075) Item 1075. The system of item 1074, wherein the predetermined position of the stopper member is a position where the stopper member is advanced to a maximum advanced position relative to the syringe body. (Item 1076) Item 1075. The system of item 1074, further comprising a sheath limiting member configured to inhibit the needle sheath from advancing past a predetermined axial extension position relative to the syringe body to a second state. (Item 1077) Item 1075. The system of item 1074, wherein the energy storage member comprises a spring. (Item 1078) Item 1075. The system of item 1074, wherein at the predetermined position, the plunger applies a load to the needle that releases a sheath retaining element. (Item 1079) The system of item 1074, wherein the syringe body comprises a commercially available syringe body. (Item 1080) The system of item 1074, wherein the syringe body has a generally cylindrical geometry. (Item 1081) Item 1075. The system of item 1074, wherein the medication chamber is configured to contain between about 0.5 cc and about 5 cc of medication. (Item 1082) Item 1082. The system of item 1081, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 1083) Item 1075. The system of item 1074, wherein the syringe body comprises a glass material. (Item 1084) The system of item 1074, wherein the syringe body comprises a polymeric material. (Item 1085) Item 12. The system of item 11, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1086) The system of item 1074, wherein the syringe body comprises metal. (Item 1087) Item 1075. The system of item 1074, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 1088) The system according to item 1087, wherein the distal outer geometry of the syringe body includes a luer lock joint. (Item 1089) The system according to item 1087, wherein the distal outer geometry of the syringe body includes a luer taper joint. (Item 1090) The system according to item 1074, wherein the syringe body defines a distal drug port. (Item 1091) The system according to item 1090, wherein the needle is selected to have a maximum outer diameter such that it can be inserted through the distal drug port of the syringe body. (Item 1092) The system according to item 1091, wherein the distal drug port has an inner diameter of about 1 mm. (Item 1093) The system according to item 1092, wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 1094) The system according to item 1074, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body for substantially sealing together with the syringe body. (Item 1095) The system according to item 1074, wherein the stopper includes an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1096) The system according to item 1074, further comprising a sealant coating applied to at least a portion of the stopper to isolate the drug material from the stopper. (Item 1097) The system according to item 1096, wherein the sealant coating includes a PTFE film. (Item 1098) The system according to item 1074, further comprising a lubricant layer introduced between the stopper and the syringe body. (Item 1099) Item 1098. The system of item 1098, wherein the lubricant layer comprises a silicone oil. (Item 1100) The system described in item 1074, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 1101) Item 1075. The system of item 1074, wherein the needle comprises at least one radially protruding locking surface feature. (Item 1102) Item 1075. The system of item 1074, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. (Item 1103) Item 1075. The system of item 1074, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 1104) Item 1075. The system of item 1074, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 1105) The system described in item 1104, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to store at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 1106) Item 1 further comprises an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid-containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid-containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid-containing surface. 074. A system as described in claim 074. (Item 1107) Item 1075. The system of item 1074, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 1108) The system of item 1107, wherein the distal end of the needle is structurally encapsulated within the internal medication chamber. (Item 1109) Item 110. The distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. 7. The system according to claim 7. (Item 1110) 1. A system for injection comprising: a. a syringe body defining an internal medication chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having a proximal end and a distal end, the proximal end connecting to the distal end of the syringe body; e. a retractable needle sheath operatively coupled to the syringe body and defining a lumen through which at least the distal end of the needle may pass, the needle sheath configured to have a first state in which the retractable needle sheath is retractably compressed toward the proximal end of the needle to expose the distal end of the needle for injection, and a second state in which the needle sheath is retractably advanced forward beyond the needle distal end to substantially cover the needle and prevent contact with the distal end of the needle; in the first state, in the absence of a sheath retaining element to hold the needle sheath in the first position until the stopper member is advanced to a predetermined position relative to the syringe body, an energy storage member is compressed to bias the needle sheath to spring forward to the second state. (Item 1111) Item 111. The system of item 1110, wherein the predetermined position of the stopper member is a position where the stopper member is advanced to a maximum advanced position relative to the syringe body. (Item 1112) Item 1110. The system of item 1110, further comprising a sheath limiting member configured to inhibit the needle sheath from advancing past a predetermined axial extension position relative to the syringe body to a second state. (Item 1113) Item 1110. The system of item 1110, wherein the energy storage member comprises a spring. (Item 1114) Item 1111. The system of item 1110, wherein at the predetermined position, the plunger applies a load to the needle that releases a sheath retaining element. (Item 1115) The system of item 1110, wherein the syringe body comprises a commercially available syringe body. (Item 1116) The system described in Item 1110, wherein the syringe body has a generally cylindrical geometry. (Item 1117) Item 1110. The system of item 1110, wherein the medication chamber is configured to hold between about 0.5 cc and about 5 cc of medication. (Item 1118) Item 1117. The system of item 1117, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 1119) The system of item 1110, wherein the syringe body comprises a glass material. (Item 1120) The system of item 1110, wherein the syringe body comprises a polymeric material. (Item 1121) The system of item 1120, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1122) The system of item 1110, wherein the syringe body comprises metal. (Item 1123) The system of item 1110, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 1124) The system described in item 1123, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 1125) The system described in item 1123, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 1126) The system of item 1110, wherein the syringe body defines a distal drug port. (Item 1127) Item 1127. The system of item 1126, wherein the needle has a maximum outer diameter selected so as to be insertable through the distal drug port of the syringe body. (Item 1128) The system described in item 1127, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 1129) Item 1128, the system wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 1130) Item 1111. The system of item 1110, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 1131) Item 1111. The system of item 1110, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1132) Item 1111. The system of item 1110, further comprising a sealant coating applied to at least a portion of the stopper to isolate a drug material from the stopper. (Item 1133) Item 1134. The system of item 1132, wherein the sealant coating comprises a PTFE film. Item 1111. The system of item 1110, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 1135) Item 1135. The system of item 1134, wherein the lubricant layer comprises silicone oil. (Item 1136) The system of item 1110, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 1137) Item 1111. The system of item 1110, wherein the needle comprises at least one radially protruding locking surface feature. (Item 1138) Item 1111. The system of item 1110, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. (Item 1139) Item 1111. The system of item 1110, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 1140) Item 1110. The system of item 1110, wherein the medicament chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 1141) The system described in item 1140, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to store at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 1142) Item 1 further comprises an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid-containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid-containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid-containing surface. 110. The system according to claim 110. (Item 1143) Item 1110. The system of item 1110, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 1144) The system of item 1143, wherein the distal end of the needle is structurally encapsulated within the internal medication chamber. (Item 1145) Item 114. The distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. 3. The system according to claim 3. (Item 1146) A system for injection, comprising: a syringe body defining an internal drug chamber and a distal junction comprising a luer taper defining an interior surface in fluid communication with the internal drug chamber; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. A system comprising: a needle having a proximal end and a distal end, the proximal end being removably attached to an inner surface of the Luer taper. (Item 1147) The system of item 1146, wherein the syringe body comprises a commercially available syringe body. (Item 1148) The system of item 1146, wherein the syringe body has a generally cylindrical geometry. (Item 1149) Item 1147. The system of item 1146, wherein the medication chamber is configured to hold between about 0.5 cc and about 5 cc of medication. (Item 1150) Item 1151. The system of item 1150, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 1151) The system of item 1146, wherein the syringe body comprises a glass material. (Item 1152) The system of item 1146, wherein the syringe body comprises a polymeric material. (Item 1153) The system of item 1152, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1154) The system of item 1146, wherein the syringe body comprises metal. (Item 1155) The system of item 1146, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 1156) The system described in item 1155, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 1157) The system described in item 1155, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 1158) The system described in item 1146, wherein the syringe body defines a distal drug port. (Item 1159) Item 1159. The system of item 1158, wherein the needle has a maximum outer diameter selected so as to be insertable through the distal drug port of the syringe body. (Item 1160) The system described in item 1159, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 1161) Item 1160, the system wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 1162) The system described in Item 1146, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 1163) Item 1147. The system of item 1146, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 1164) Item 1164. The system of item 1163, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 1165) Item 1147. The system of item 1146, wherein the stopper has an outer geometry selected to substantially match the inner geometry of the syringe body to substantially seal with the syringe body. (Item 1166) Item 1147. The system of item 1146, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1167) The system of claim 1146, further comprising a sealant coating applied to at least a portion of the stopper to isolate drug material from the stopper. (Item 1168) Item 1167, the system wherein the sealant coating comprises a PTFE film. (Item 1169) Item 1147. The system of item 1146, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 1170) Item 1169. The system of item 1169, wherein the lubricant layer comprises silicone oil. (Item 1171) The system described in item 1146, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 1172) Item 1172. The system of item 1171, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 1173) Item 1147. The system of item 1146, wherein the needle comprises at least one radially protruding locking surface feature. (Item 1174) Item 1174. The system of item 1173, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 1175) Item 1175. The system of item 1174, wherein the piercing element has a pointed tip. (Item 1176) Item 1175. The system of item 1175, wherein the penetrating element comprises a solid structure having no lumen or aperture defined therethrough. (Item 1177) Item 1178. The system of item 1174, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. Item 1174. The system of item 1173, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 1179) Item 1179. The system of item 1178, wherein the cannula member and hub member are formed from the same piece of material. (Item 1180) Item 1179. The system of item 1178, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 1181) Item 1179. The system of item 1178, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form part of the needle. (Item 1182) Item 1181. The system of item 1180, wherein the hub member is formed from a single piece of tubing. (Item 1183) Item 1179. The system of item 1178, wherein the proximal member comprises a piece of flat sheet metal having a proximal connection joint. (Item 1184) The system of item 1181, wherein the cannula member comprises metal. (Item 1185) The system of item 1181, wherein the hub comprises a metal or plastic material. (Item 1186) The proximal member may be made of a metal or plastic material, the system being described in item 1181. (Item 1187) Item 1147. The system of item 1146, further comprising an energy storage member operably connected between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 1188) The system of claim 1187, wherein the plunger member comprises a plunger member body defining an internal volume, and the energy storage member is housed substantially within the internal volume of the plunger member body. (Item 1189) The system described in item 1188, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 1190) The system described in Item 1189, wherein the locking member has a trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 1191) Item 1191. The system of item 1190, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 1192) Item 1187, the system wherein the energy storage member is a spring. (Item 1193) The system described in Item 1192, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 1194) Item 1193. The system of item 1192, wherein the spring comprises an elastomeric polymer. (Item 1195) The system of claim 1194, wherein the elastomeric polymer is selected from the group consisting of styrene-based polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 1196) Item 1188. The system of item 1187, wherein the energy storage member comprises a solid pellet member. (Item 1197) Item 1197. The system of item 1196, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 1198) Item 1199. The system of item 1192, wherein the spring includes a single generally helical shaped coil. Item 1200. The system of item 1192, wherein the spring includes a plurality of generally helical shaped coils. Item 1199, a system according to item 1199, wherein at least two of the coils comprising the plurality of generally spiral-shaped coils are coaxially aligned. (Item 1201) Item 1199, a system according to item 1199, wherein at least two of the coils comprising the plurality of generally spiral-shaped coils are aligned longitudinally parallel. (Item 1202) Item 120. The system of item 1200, wherein the coaxially aligned helical coils are also aligned parallel to the longitudinal direction. (Item 1203) Item 1202. The system of item 1202, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 1204) The system of claim 1187, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 1205) Item 1147. The system of item 1146, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. (Item 1206) Item 1147. The system of item 1146, wherein the plunger comprises a plunger distal end threaded joint configured to be spirally inserted into the stopper member and to couple to the stopper member upon such insertion. (Item 1207) Item 1147. The system of item 1146, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 1208) Item 1208. The system of item 1207, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 1209) The system described in item 1207, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 1210) Item 1189, the system further comprising a trigger engagement member coupled to the syringe body and configured to engage the trigger portion of the locking member through a trigger engagement window defined through at least a portion of the plunger member. (Item 1211) The system of item 1146, further comprising a proximal sealing portion configured to encapsulate the stopper member within the internal drug chamber of the syringe body such that a vacuum load is created when the stopper is inserted into the internal drug chamber. (Item 1212) The system described in item 1211, further comprising a brake member operably connected to the plunger member and the syringe body, the brake member configured to facilitate insertion of the plunger member into the syringe body but resist retraction of the plunger member into the syringe body in a first mode until the brake member is disposed in a second mode of a brake release configuration. (Item 1213) Item 1212. The system of item 1212, wherein the damping member comprises a plate aperture damping portion. (Item 1214) Item 1214. The system of item 1213, wherein the plate aperture stopper comprises a piece of sheet metal having an aperture formed therethrough. (Item 1215) The system of claim 1210, further comprising a spring member configured to facilitate retraction of the plunger relative to the syringe body after the plunger is fully inserted relative to the syringe body. (Item 1216) Item 1216. The system of item 1215, wherein the plate aperture damping portion is configured to switch from the first mode to the second mode by inducing plastic deformation of at least a portion of the spring member. (Item 1217) Item 1213. The system of item 1212, wherein retraction of the plunger member is facilitated in the second mode through application of a retraction initiation load. (Item 1218) Item 1217. The system of item 1217, wherein the storage initiation load is applied by a spring member operably connected to the brake member. (Item 1219) Item 1218. The system of item 1217, wherein the retraction initiation load is applied by a spring member coupled between the plunger member and the syringe body. (Item 1220) Item 1219. The system of item 1218, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 1221) Item 1219. The system of item 1219, wherein the spring member is selected from the group consisting of a coil spring, a leaf spring, and an elastomeric spring element. (Item 1222) Item 1212. The system of item 1211, wherein the vacuum load is sufficient to at least partially retract the plunger relative to the syringe body. (Item 1223) The system of claim 1222, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 1224) Item 1147. The system of item 1146, wherein the medication chamber is defined by a chamber length and the needle is defined by a needle length that is equal to or greater than the chamber length. (Item 1225) Item 1225. The system of item 1224, further comprising an extension member connected to a proximal end of the syringe body, the extension member operably connected to the plunger member and configured to house at least a portion of the needle when the needle is fully retracted into a volume defined by the internal drug chamber and the extension member. (Item 1226) Item 1 further comprises an extension member coupled to a proximal end of the syringe body, the extension member operably coupled to the plunger member and configured to accommodate the stopper member when it is retracted to an extent that it at least partially exits the internal medicament chamber, the extension member comprising a fluid-containing surface positioned directly adjacent to the distal surface upon retraction of the stopper member into the extension chamber, the fluid-containing surface configured to accommodate residual droplets of medicament and remain coupled to the distal surface of the stopper member until they are accommodated by the fluid-containing surface. 146. The system according to claim 146. (Item 1227) Item 1147. The system of item 1146, wherein the plunger member is configured to be manually retracted by an operator such that the distal end of the needle becomes structurally encapsulated and subsequent access to the distal end of the needle is prevented. (Item 1228) The system of item 1227, wherein the distal end of the needle is structurally encapsulated within the internal medication chamber. (Item 1229) Item 122. The distal end of the needle is structurally encapsulated by a needle door member, the needle door member movably coupled to the syringe body, and configured to have a first state in which the needle door member facilitates insertion of the needle into the syringe body and a second state in which the needle door member prevents insertion of the needle into the syringe body. 7. The system according to claim 7. (Item 1230) 1. A system for injection comprising: a syringe body defining an internal medication chamber and a distal needle junction; b. a stopper member configured to be inserted into the inner medicament chamber to contain a medicament within the medicament chamber; c. a plunger member configured to be manually manipulated to insert the stopper member into the syringe body; and d. a needle having a proximal end and a distal end, the proximal end being removably attached to a distal needle interface of the syringe body; e. a needle seal operatively coupled between the needle and a distal needle junction, the needle seal configured to prevent fluid flow between an exterior surface of the needle and the distal needle junction; The system, wherein the needle is coupled to at least one radially protruding locking feature, the locking feature configured to mate with a mechanical lock to prevent axial movement of the needle relative to the syringe body in a locked configuration and to facilitate axial movement of the needle relative to the syringe body in an unlocked configuration. (Item 1231) The system of item 1230, wherein the needle comprises a pointed distal end. (Item 1232) Item 1231. The system of item 1230, comprising a pointed proximal end configured to pierce at least a portion of the stopper member. (Item 1233) Item 1231. The system of item 1230, further comprising a locking interface surface coupled to the distal needle interface and configured to mechanically facilitate the locking configuration. (Item 1234) Item 1233, wherein the locking interface surface is formed into the distal portion of the syringe body. The system described in (Item 1235) Item 1234. The system of item 1233, wherein the locking interface surface comprises a separate locking interface member operably coupled to the syringe body. (Item 1236) Item 1234. The system of item 1233, wherein in the locking configuration, the radially protruding locking features couple into recesses formed in the locking interface surfaces. (Item 1237) Item 1234. The system of item 1233, wherein in an unlocked configuration, the radially protruding locking feature aligns with an aperture formed in the locking interface surface that facilitates passage of the radially protruding locking feature through the locking interface surface so that the needle may be inserted or retracted relative to the syringe body. (Item 1238) Item 1237. The system of item 1236, wherein in the unlocked configuration, the radially protruding locking feature aligns with an aperture formed in the locking interface surface that facilitates passage of the radially protruding locking feature through the locking interface surface so that the needle may be inserted or retracted relative to the syringe body, and the recesses and apertures are at different radial positions relative to each other on the locking interface surface such that rotation of the needle between radial positions changes state between the locked configuration and the unlocked configuration. (Item 1239) Item 1239. The system of item 1238, wherein the radial positions of the depressions and apertures are separated by approximately 60 degrees relative to one another on the locking interface surface. (Item 1240) The system described in item 1232, wherein a twisted portion of the needle member is interposed between the sharpened proximal end and the distal end of the needle, the twisted portion being configured to rotate the needle relative to the stopper when the sharpened proximal end and at least a portion of the twisted portion are inserted into the stopper. (Item 1241) Item 1231. The system of item 1230, wherein the needle seal comprises a first compliant member configured to be compressed in the locked state to maintain the needle locked and to be further compressed to facilitate conversion to an unlocked configuration. (Item 1242) Item 1241. The system of item 1241, further comprising a seal backing member coupled to the first compliant member and configured to substantially maintain a geometry of a central portion of the first compliant member relative to the needle and reduce contact friction between the needle and the first compliant member. (Item 1243) The system of item 1230, wherein the syringe body comprises a commercially available syringe body. (Item 1244) The system of item 1230, wherein the syringe body has a generally cylindrical geometry. (Item 1245) Item 1231. The system of item 1230, wherein the medication chamber is configured to hold between about 0.5 cc and about 5 cc of medication. (Item 1246) Item 1245. The system of item 1245, wherein the medication chamber is configured to accommodate a volume of medication selected from the group consisting of 0.5cc, 1cc, 2.25cc, 3cc, and 5cc. (Item 1247) The system of item 1230, wherein the syringe body comprises a glass material. (Item 1248) The system of item 1230, wherein the syringe body comprises a polymeric material. (Item 1249) The system of item 1248, wherein the polymeric material is selected from the group consisting of COP, COC, polyester, and polypropylene. (Item 1250) The system of item 1230, wherein the syringe body comprises a metal. (Item 1251) The system of item 1230, wherein the syringe body comprises a distal outer geometry configured to mechanically couple to one or more other device elements. (Item 1252) The system described in item 1251, wherein the distal outer geometry of the syringe body includes a Luer lock junction. (Item 1253) The system described in item 1251, wherein the distal outer geometry of the syringe body includes a Luer taper junction. (Item 1254) The system of item 1230, wherein the syringe body defines a distal drug port. (Item 1255) Item 1255. The system of item 1254, wherein the needle has a maximum outer diameter selected so as to be insertable through the distal drug port of the syringe body. (Item 1256) The system described in item 1255, wherein the distal drug port has an inner diameter of approximately 1 mm. (Item 1257) Item 1256, the system wherein the needle has a size of about 34 gauge to about 20 gauge. (Item 1258) Item 1231. The system of item 1230, wherein the stopper member is configured to be at least partially penetrated by the sharp proximal end of the needle. (Item 1259) Item 1231. The system of item 1230, wherein the needle has at least one anchor element configured to resist withdrawal after penetrating at least partially into the stopper member. (Item 1260) Item 1259. The system of claim 1259, wherein the at least one anchor element is selected from the group consisting of a barb, a skive cut, a hook geometry, an arrowhead geometry, a wavy radial geometry, an expanded faceted barb configuration, and a deformable member that is insertable in a relatively small cross-sectional state and configured to deform to a larger cross-sectional state. (Item 1261) Item 1231. The system of item 1230, wherein the stopper has an outer geometry selected to substantially match an inner geometry of the syringe body to substantially seal with the syringe body. (Item 1262) Item 1231. The system of item 1230, wherein the stopper comprises an elastomeric material selected from the group consisting of chlorobutyl rubber, bromobutyl rubber, and silicone rubber. (Item 1263) The system of claim 1230, further comprising a sealant coating applied to at least a portion of the stopper to isolate a drug material from the stopper. (Item 1264) The system of claim 1263, wherein the sealant coating comprises a PTFE film. (Item 1265) Item 1231. The system of item 1230, further comprising a lubricant layer disposed between the stopper and the syringe body. (Item 1266) Item 1266. The system of item 1265, wherein the lubricant layer comprises silicone oil. (Item 1267) The system of item 1230, wherein the distal portion of the stopper member comprises a conventional commercially available compliant stopper. (Item 1268) Item 1267. The system of item 1267, wherein the stopper member comprises an unmodified solid compliant member having no recesses or protrusions for connection to a needle. (Item 1269) Item 1231. The system of item 1230, wherein the needle comprises at least one radially protruding locking surface feature. (Item 1270) Item 1269 is a system according to item 1269, wherein the proximal end of the needle includes at least one piercing element located proximally relative to at least one anchor element. (Item 1271) Item 1271. The system of item 1270, wherein the piercing element comprises a pointed tip. (Item 1272) Item 1272. The system of item 1271, wherein the penetrating element comprises a solid structure having no lumen or aperture defined therethrough. (Item 1273) Item 1272. The system of item 1271, wherein the needle defines an injection passage therethrough, the injection passage being selected to lead from a distal tip of the needle to a location proximal to the distal tip of the anchor element. (Item 1274) Item 1269. The system of item 1269, wherein the needle comprises a cannula member, a hub member, and a proximal member. (Item 1275) The system of item 41274, wherein the cannula member and hub member are formed from the same piece of material. (Item 1276) Item 1275. The system of item 1274, wherein the cannula member and hub member comprise separately formed elements fixedly connected together to form a portion of the needle. (Item 1277) Item 1275. The system of item 1274, wherein the proximal member also comprises a separately formed element fixedly coupled to the cannula member and hub member to form part of the needle. (Item 1278) Item 1277. The system of item 1276, wherein the hub member is formed from a single piece of tubing. (Item 1279) Item 1275. The system of item 1274, wherein the proximal member comprises a piece of flat sheet metal having a proximal connection joint. (Item 1280) The system of item 1277, wherein the cannula member comprises metal. (Item 1281) Item 1277, the system comprising the hub comprising a metal or plastic material. (Item 1282) The proximal member may be made of a metal or plastic material, the system being described in item 1277. (Item 1283) Item 1231. The system of item 1230, further comprising an energy storage member operably connected between the stopper member and the syringe body, the energy storage member configured to facilitate retraction of the stopper member relative to the syringe body. (Item 1284) The system of claim 1283, wherein the plunger member comprises a plunger member body defining an internal volume, the energy storage member being housed substantially within the internal volume of the plunger member body. (Item 1285) Item 1285. The system of item 1284, further comprising a locking member operably coupled to the plunger member and substantially contained within an internal volume of the plunger member body, the locking member configured to have a first mechanical state in which the locking member maintains the energy storage member in an energy stored state, and a second mechanical state in which the locking member causes the energy storage member to release energy stored by the energy storage member to assist in retraction of the stopper member relative to the syringe body. (Item 1286) The system described in Item 1285, wherein the locking member includes a trigger portion extending outside the internal volume of the plunger member body and operably connected to the syringe body such that the energy storage member can be automatically released when the plunger member and interconnected stopper member reach a predetermined insertion position relative to the syringe body. (Item 1287) Item 1287. The system of item 1286, wherein the predetermined insertion position is a position where the stopper is positioned in a fully inserted state relative to the syringe body. (Item 1288) Item 1284. The system of item 1283, wherein the energy storage member is a spring. (Item 1289) Item 1289. The system of item 1288, wherein the spring comprises a material selected from the group consisting of stainless steel, carbon steel, beryllium copper alloy, nickel titanium alloy, chromium silicon alloy, and cobalt nickel alloy. (Item 1290) The system of item 1288, wherein the spring comprises an elastomeric polymer. (Item 1291) The system of claim 1290, wherein the elastomeric polymer is selected from the group consisting of styrene-based polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubber. (Item 1292) Item 1284. The system of item 1283, wherein the energy storage member comprises a solid pellet member. (Item 1293) Item 1292. The system of item 1292, wherein the solid pellet member is an elastomeric polymer selected from the group consisting of styrenic polymers, copolyester polymers, polyurethanes, polyamides, polyolefin blends, polyolefin alloys, polyolefin plastomers, polyolefin plastomers, and rubbers. (Item 1294) Item 1295. The system of item 1288, wherein the spring includes a single generally helical shaped coil. Item 1296. The system of item 1288, wherein the spring includes a plurality of generally helical shaped coils. Item 1295, a system according to item 1295, wherein at least two of the coils comprising the plurality of generally helical shaped coils are coaxially aligned. (Item 1297) Item 1295, a system according to item 1295, wherein at least two of the coils comprising the plurality of generally spiral-shaped coils are aligned longitudinally parallel. (Item 1298) Item 1297. The system of item 1296, wherein the coaxially aligned spiral-shaped coils are also aligned parallel to the longitudinal direction. (Item 1299) Item 1299. The system of item 1298, wherein the coaxially and longitudinally aligned helical shaped coils are helically wound in opposite winding directions relative to each other to prevent coil interference upon compression of the coils. (Item 1300) The system of claim 1283, wherein retraction of the plunger retracts the interconnected stopper member and needle, such that at least a portion of the needle is retracted into the internal drug chamber of the syringe body. (Item 1301) Item 1231. The system of item 1230, wherein the plunger comprises a proximal thumb pad configured to facilitate manual insertion and retraction control of the plunger relative to the syringe body. (Item 1302) Item 1231. The system of item 1230, wherein the plunger comprises a plunger distal end threaded joint configured to be helically inserted into the stopper member and coupled to the stopper member by such insertion. (Item 1303) Item 1231. The system of item 1230, wherein the plunger member comprises a plurality of ratchet mechanisms positioned on a surface of the plunger member, the ratchet mechanisms configured to prevent reinsertion of the plunger member into the syringe body after the plunger member has been initially inserted into a predetermined position relative to the syringe body. (Item 1304) Item 1304. The system of item 1303, wherein the predetermined position is a position in which the stopper member is advanced to a position where it is fully inserted by the plunger member into the syringe body. (Item 1305) The system described in item 1303, further comprising a locking member operably connected between the plunger member and the syringe body, the locking portion comprising at least one ratchet tooth engageable with the ratchet mechanism and a proximal joint engageable with a handle portion of the syringe body. (Item 1306) Item 1285. The system of item 1285, further comprising a trigger engagement member coupled to the syringe bo...

Claims

1. A system for mixing and injecting pharmaceutical formulations, the system comprising: a syringe body (34), said syringe body (34) defining a proximal opening and a distal needle junction at a distal end thereof; proximal and distal stopper members (32, 36) disposed within the syringe body (34), the proximal and distal stopper members (32, 36) defining a proximal medicament chamber between the proximal and distal stopper members (32, 36) and a distal medicament chamber between the distal stopper member (36) and the distal end of the syringe body (34); a plunger member defining a plunger interior, the plunger member configured to be manually manipulated to insert the proximal stopper member (32) into the syringe body (34); a needle hub assembly (58) connected to the distal needle joint of the syringe body (34); Equipped with The needle hub assembly (58) includes a needle having a needle proximal end (50); the proximal and distal stop members (32, 36) are configured such that distal movement of the proximal stop member (32) moves the distal stop member (36) distally before the needle proximal end (50) pierces the distal stop member (36), thereby causing the needle proximal end (50) to pierce the distal stop member (36) and the needle forms a fluid passageway between the proximal and distal drug chambers; Manual actuation of the plunger member to distally displace the distal stop member (36) and penetrate the needle proximal end (50) through the distal stop member (36) initiates transfer of drug from the proximal drug chamber to the distal drug chamber through the fluid passageway.

2. The system of claim 1, wherein the needle proximal end (50) is configured to enter inside the plunger when the plunger is manually manipulated to move the proximal and distal stopper members (32, 36) distally to the distal end of the distal drug chamber.

3. The system of claim 1, wherein the proximal and distal drug chambers respectively contain first and second components of a drug that are mixed prior to injection into a patient.

4. The system of claim 3, wherein the first component is a fluid and the second component is a solid.

5. The needle, a proximal mixing opening; Distal mixing opening and The system of claim 1 , comprising:

6. The system described in claim 5, wherein a fluid passage is formed between the proximal drug chamber and the distal drug chamber when the needle proximal end (50) distally pierces the distal stopper member (36).

7. The needle, a proximal injection opening; Distal injection opening and The system of claim 5 further comprising:

8. The needle, The system of claim 7 , further comprising a lumen plug disposed in the needle between the distal mixing opening and the proximal injection opening.

9. The system of claim 8, wherein the fluid passage enables mixing of first and second components in the proximal and distal drug chambers.

10. The system of claim 8, wherein the proximal and distal stop members (32, 36) are configured such that further distal movement of the proximal and distal stop members (32, 36) forces the mixed medication through the proximal injection opening, through the needle, and out the distal injection opening and into the patient.

11. The system of claim 1, wherein the syringe body (34) has a distal outer geometry configured to be mechanically coupled to the needle hub assembly (58).

12. The system described in claim 11, wherein the distal outer geometry of the syringe body (34) includes a Luer lock joint.

13. The system described in claim 11, wherein the distal outer geometry of the syringe body (34) includes a Luer taper junction.

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