Ozone-containing composition and method for producing ozone-containing composition

Abstract

SOLUTION: An ozone-containing composition according to the present invention contains a volatile oily solvent, a volatile aqueous solvent, and ozone. The volatile oily solvent is one or two or more kinds of volatile fluid paraffins selected from the group consisting of light isoparaffin, light fluid isoparaffin, and hydrogenated polyisobutene, a volatile silicone oil containing cyclic dimethyl silicone oil, or a mixture thereof, and has concentration in the range of 10 wt.% to 90 wt.% with reference to the total composition. The volatile aqueous solvent is a volatile alcohol, a volatile ketone, or a mixture thereof, and has concentration in the range of 10 wt.% to 90 wt.% with reference to the total composition.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to an ozone-containing composition and a method for producing an ozone-containing composition. [Background technology]

[0002] Ozone (ozone gas) has been known to have a very strong bactericidal power, which is due to the destruction of bacterial cell membranes or nucleic acids. Therefore, compared to general disinfectants and antibiotics, ozone is capable of inactivating (killing) all bacteria, including highly durable spore-forming bacteria, and has the characteristic of not generating resistant bacteria.

[0003] The present inventor has independently developed disinfectants and germicides containing ozone by utilizing such characteristics of ozone, filed patent applications, and obtained rights.For example, JP-T-2009-525974 (Patent Document 1) discloses a disinfectant containing ozone, which is a disinfectant that is given germicidal power by mixing ozone into liquid paraffin or Vaseline and stirring the mixture to make the ozone contained therein.In addition, JP-A-2013-234132 (Patent Document 2) discloses an ozone-containing silicone oil that is given germicidal power by blowing ozone into silicone oil as bubbles and stirring the silicone oil, thereby making the silicone oil contain ozone as fine bubbles. Furthermore, Japanese Patent Application Laid-Open No. 2015-071586 (Patent Document 3) discloses a volatile disinfectant which is obtained by stirring a volatile solvent containing volatile liquid paraffin, volatile silicone oil, or a mixture thereof as a base while blowing ozone gas into the volatile solvent, thereby causing the volatile solvent to contain ozone gas; when the disinfectant is applied to a specified object, it inactivates pathogens on the object and then volatilizes from the object.

[0004] On the other hand, in addition to the use of disinfection and sterilization, the above-mentioned characteristics of ozone are being used to develop pest control and insecticide, and to decontaminate and decompose anticancer drugs used in medical settings. For example, Japanese Patent Laid-Open Publication No. 05-170610 (Patent Document 4) discloses a method for exterminating pests by exposure to ozone. It is said that household pests and pests called nuisance pests, such as cockroaches, mites, termites, fleas, lice, flies, and mosquitoes, can be exterminated by exposure to ozone at a concentration of 0.2 ppm or more, or to the ozone and a small amount of nitrogen oxides. It is also said that pest extermination can be performed efficiently by a pest extermination device equipped with an ozone generation means and an ozone decomposition means.

[0005] In addition, JP 2019-208864 A (Patent Document 5) discloses a sterilization or pest control system for sterilizing or pest-controlling fruits and vegetables by exposing the fruits and vegetables to a sterilizing or pest-control gas having a sterilizing or pest-control effect in a gas-filled space. This system includes a memory unit, a selection designation receiving unit, a decision processing unit, and a control processing unit. The memory unit stores a combination of the gas concentration of the sterilizing or pest-control gas and the exposure time of the fruits and vegetables to the sterilizing or pest-control gas as a sterilization or pest control condition for each type of fruits and vegetables. The selection designation receiving unit accepts the selection of the type of fruits and vegetables and the designation of the exposure time or gas concentration. The decision processing unit reads out the sterilization or pest control condition corresponding to the type of fruits and vegetables selected by the selection designation receiving unit from the memory unit, and determines the gas concentration corresponding to the exposure time designated by the selection designation receiving unit, or the exposure time corresponding to the gas concentration designated by the selection designation receiving unit. The control processing section generates a sterilizing or pest control gas and maintains the gas concentration in the gas-filled space determined by the determination processing section, or controls the exposure of the fruits or vegetables to the sterilizing or pest control gas for the exposure time determined by the determination processing section. The sterilizing or pest control gas is ozone gas. This makes it possible to obtain a sufficient sterilizing or pest control effect at a gas concentration or exposure time that does not cause damage to the fruits or vegetables by using a sterilizing or pest control gas that has a sterilizing or pest control effect on the fruits or vegetables.

[0006] In addition, Patent Publication No. 2019-073996 (Patent Document 6) discloses a harmful substance treatment method in which ozone gas is applied to decompose or sterilize harmful substances in an environment humidified with an aqueous surfactant solution. The harmful substances are anticancer drugs, and the surfactants used include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. This makes it possible to decompose harmful substances that are not easily decomposed by ozone gas alone, or to promote the detoxification of harmful microorganisms.

[0007] Furthermore, Patent Publication No. 2014-208428 (Patent Document 7) discloses a method for decomposing an anticancer drug by using air containing ozone and humidified by a humidifying means to decompose the anticancer drug. This method is said to be able to protect medical staff from anticancer drugs that are scattered outside (safety cabinets, dispensing rooms, etc.) during dispensing, etc. [Prior art documents] [Patent documents]

[0008] [Patent Document 1] Special Publication No. 2009-525974 [Patent Document 2] JP 2013-234132 A [Patent Document 3] JP 2015-071586 A [Patent Document 4] Japanese Patent Application Publication No. 05-170610 [Patent Document 5] JP 2019-208864 A [Patent Document 6] Re-tabled publication 2019-073996 [Patent Document 7] Re-tabled publication No. 2014-208428 Summary of the Invention [Problem to be solved by the invention]

[0009] By the way, gas, liquid, and solid chemicals are used to kill and exterminate pests, but these chemicals usually have a problem that they have a bad effect on the human body.Also, chemicals usually have a residual effect, so there is a problem that the chemicals remaining after application have a bad effect on the external environment.Furthermore, even if ozone is sprayed on pests, there are cases where the pests do not die, and there is a problem that ozone alone is not useful for killing and exterminating pests.

[0010] The same is true for the decontamination and decomposition of anticancer drugs handled in medical settings. Although anticancer drugs have a pharmacological effect on patients when administered appropriately, they may cause health problems for medical professionals other than patients, such as doctors, nurses, and pharmacists. For example, medical professionals may develop health problems due to inhalation exposure to vaporized anticancer drugs or percutaneous exposure due to contact with leaked anticancer drugs, causing acute symptoms such as gastrointestinal symptoms and circulatory symptoms, or leading to the onset of cancer due to the chronic toxicity (carcinogenicity, etc.) of anticancer drugs. Therefore, in actual situations, medical experts carefully prepare, administer, and dispose of anticancer drugs according to prescribed procedures, but there is a problem that these measures are not sufficient. In addition, there is a problem that the processing agents used for general decontamination and decomposition of anticancer drugs remain on the anticancer drugs after application or contaminate the target of application. Here, the technology described in Patent Documents 1-7 cannot solve the above-mentioned problems.

[0011] Therefore, the present invention has been made to solve the above problems, and an object of the present invention is to provide an ozone-containing composition and a method for producing an ozone-containing composition which have an insecticidal effect, an insect pest repellent effect, and an effect of decontaminating and decomposing an anticancer drug, which is safe for the human body, and which allows easy post-treatment after application. [Means for solving the problem]

[0012] The ozone-containing composition according to the present invention contains a volatile oily solvent, a volatile aqueous solvent, and ozone. The volatile oily solvent is one or more volatile liquid paraffins selected from the group consisting of light isoparaffin, light liquid isoparaffin, and hydrogenated polyisobutene, a volatile silicone oil containing cyclic dimethyl silicone oil, or a mixture thereof, and has a concentration within the range of 10% to 90% by weight based on the total composition. The volatile aqueous solvent is a volatile alcohol, a volatile ketone, or a mixture thereof, and has a concentration within the range of 10% to 90% by weight based on the total composition.

[0013] The method for producing an ozone-containing composition according to the present invention includes a mixing step and a stirring step. The mixing step is to put a volatile oily solvent, a volatile aqueous solvent, and ozone as a mixture into a predetermined mixing tank and mix them. The stirring step is to stir the mixture in the mixing tank with a predetermined stirrer.

Advantages of the Invention

[0014] According to the present invention, it has effects such as an insecticidal effect, a pest repellent effect, decontamination and decomposition of anticancer agents, etc., is safe for the human body, and enables easy post-treatment after application.

Brief Description of the Drawings

[0015] [Figure 1] It is a conceptual diagram showing a method for producing an ozone-containing composition according to the present invention. [Diagram 2] They are a front photo, a right side photo, and a left side photo immediately after spraying, showing an example of the insecticidal test result of mosquitoes in Example 1. [Diagram 3] It is a photo showing an example of the anti-mite property test results in Reference Example 1 and Example 1. [Figure 4] It is a table of each component and evaluation results of the ozone-containing compositions of Example 1-7 and Comparative Example 1-2. [Diagram 5] It is a table of each component and evaluation results of the ozone-containing compositions of Example 8-16. [Figure 6] It is a table of each component and evaluation results of the ozone-containing compositions of Example 17-27. [Figure 7] Table showing each component and evaluation results of the ozone-containing compositions of Examples 28-34.

BEST MODE FOR CARRYING OUT THE INVENTION

[0016] Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings to aid in understanding the present invention. Note that the following embodiments are an example of embodying the present invention and do not limit the technical scope of the present invention.

[0017] The present inventors have been intensively researching disinfectants and bactericides containing ozone for many years. Such disinfectants and bactericides basically dissolve ozone in an oily solvent, retain the ozone in the oily solvent, and bring the oily solvent into contact with bacteria, so that the ozone in the oily solvent contacts the bacteria and inactivates the bacteria.

[0018] Here, the present inventors tried to apply such disinfectants and bactericides to insecticidal and repellent effects on pests. However, unexpectedly, pests have a strong hydrophilic nature, and even when an oily solvent in which ozone is dissolved is applied to pests, it has been found that the desired insecticidal effect and pest repellent effect cannot be obtained. Here, insects such as pests do not have lungs and breathe by directly exchanging oxygen and carbon dioxide through tracheae. However, even when ozone is sprayed on pests, the ozone does not properly contact the tracheae of the pests, so it does not interfere with the respiration of the pests, and it has been found that it is difficult to kill or repel pests with only ozone.

[0019] In addition, the present inventors also tried to decontaminate and decompose anticancer agents. Similar to the above, since anticancer agents also have a hydrophilic nature, even when an oily solvent in which ozone is dissolved is applied to the anticancer agents, the effect of decontaminating and decomposing the anticancer agents could not be obtained.

[0020] Therefore, the present inventor added a certain amount of an aqueous solvent that is miscible with the oily solvent, and surprisingly discovered that the ozone in the oily solvent contacted the trachea of ​​pests through the aqueous solvent, resulting in an insecticidal effect and an insect repellent effect. The same was true for the decontamination and decomposition of anticancer drugs, and the inventor discovered that the ozone in the oily solvent contacted the anticancer drug through the aqueous solvent, resulting in the decontamination and decomposition effects of the anticancer drug. As a result, the present inventor completed the present invention based on the examples described below.

[0021] That is, the ozone-containing composition according to the present invention contains a volatile oily solvent, a volatile aqueous solvent, and ozone. Here, the volatile oily solvent is one or more volatile liquid paraffins selected from the group consisting of light isoparaffin, light liquid isoparaffin, and hydrogenated polyisobutene, and a volatile silicone oil including cyclic dimethyl silicone oil, and the concentration of the volatile aqueous solvent is within the range of 10% by weight to 90% by weight based on the total composition. Furthermore, the volatile aqueous solvent is a volatile alcohol, a volatile ketone, or a mixture thereof, and the concentration of the volatile aqueous solvent is within the range of 10% by weight to 90% by weight based on the total composition.

[0022] Here, volatile liquid paraffin and volatile silicone oil are lipophilic and stable against ozone (do not oxidize). In addition, the boiling point of volatile liquid paraffin is about 170 degrees, and the boiling point of volatile silicone oil is within the range of 170 degrees to 200 degrees, so both volatile liquid paraffin and volatile silicone oil will volatilize and dry if left exposed to the atmosphere for a while. The SP value of volatile liquid paraffin {(cal / cm 3 ) 1 / 2} is in the range of 6.5 to 7.5, and the SP value of the volatile silicone oil {(cal / cm 3 ) 1 / 2 The SP value of the volatile liquid paraffin and the SP value of the volatile silicone oil are in the range of 6.5 to 9.5, and the SP value of the volatile liquid paraffin and the SP value of the volatile silicone oil overlap partially, and the volatile liquid paraffin is mixed uniformly with the volatile silicone oil without reacting with it. 3 ) 1 / 2 is (energy of evaporation / molar volume) 1 / 2SP is a parameter that reflects the cohesive force of a substance, and solvents with close or overlapping SP values ​​have good compatibility. The above SP value is an estimated value by the Fedors method. In the present invention, ozone is dissolved in such a volatile oily solvent.

[0023] On the other hand, the volatile alcohols and volatile ketones of the volatile aqueous solvents are hydrophilic and lipophilic. Here, the volatile alcohols refer to alcohols having a boiling point of about 150°C or less, and the volatile ketones refer to ketones having a boiling point of about 150°C or less. The SP value of the volatile alcohols {(cal / cm 3 ) 1 / 2} is in the range of 10.0 to 13.8, and the SP value of the volatile ketone {(cal / cm 3 ) 1 / 2} is within the range of 8.0 to 10.0. That is, the SP value of the volatile alcohol and the SP value of the volatile ketone overlap partially, and also overlap partially with the SP value of the volatile liquid paraffin and the SP value of the volatile silicone oil. The volatile alcohol is mixed uniformly without reacting with the volatile ketone, and the volatile alcohol and the volatile ketone are mixed uniformly without reacting with the volatile liquid paraffin and the volatile silicone oil. Furthermore, the volatile alcohol and the volatile ketone have a lower reactivity with ozone compared with carboxylic acids and fatty acids. Therefore, in the present invention, by mixing a volatile aqueous solvent with a volatile oily solvent and ozone, the hydrophilic properties are imparted as a whole, which increases the contact with the trachea of ​​pests and the anticancer drug, and makes it possible to effectively contact the ozone with the anticancer drug and pests, thereby obtaining an insecticidal effect, an insect repellent effect, and an anticancer drug decontamination and decomposition effect.

[0024] In addition, the volatile oil-based solvents, volatile liquid paraffin and volatile silicone oil, are used in cosmetics, food additives, etc., and are harmless to the human body even if the user inhales them. In addition, ozone is approved as a food additive by the U.S. Food and Drug Administration (FDA), and is harmless to the human body if it is in a low concentration, even if the user inhales it. Furthermore, the volatile aqueous solvents, volatile alcohol and volatile ketone, are unlikely to affect the human body, so it is possible to ensure safety overall. Therefore, the present invention can exert effects such as insecticidal effects, pest repellent effects, and decontamination and decomposition of anticancer drugs without damaging the health of the user who handles it.

[0025] Here, since the volatile oil-based solvent and the volatile aqueous solvent hardly react with ozone, for example, if the present ozone-containing composition is stored in a sealed state, it can be stored for a long period of time without inactivating (oxidizing) the ozone.

[0026] In this way, the ozone-containing composition of the present invention can suitably obtain insecticidal effects, pest repellent effects, decontamination and decomposition effects of anticancer drugs, etc. in the fields of hygiene, medicine, agriculture, dairy farming, etc. In addition, it can be applied to other uses and fields where hydrophilic objects need to be decomposed by ozone.

[0027] Here, the type of ozone is not particularly limited, and examples thereof include a mixed gas of ozone and oxygen, a single gas of ozone only, etc. The mixture ratio of ozone and oxygen in the mixed gas is, for example, in the range of 50% by weight-2% by weight for ozone and 50% by weight-98% by weight for oxygen.

[0028] In addition, there is no particular limitation on the concentration of ozone in the present ozone-containing composition, and from the standpoint of the reliability of the insecticidal effect, pest repellent effect, decontamination and decomposition of anticancer drugs, and safety to the human body, the concentration of ozone in the present ozone-containing composition is preferably in the range of 10 ppm to 500 ppm, and more preferably in the range of 20 ppm to 400 ppm. Here, there is a legal exposure regulation (work environment permissible concentration) that limits the concentration of ozone in the atmosphere to 0.1 ppm or less, but by keeping the concentration of ozone within the above-mentioned range, the concentration of ozone in the atmosphere that evaporates together with the volatile solvent can be kept within the legal exposure regulation, ensuring safety to the human body.

[0029] In addition, the type of volatile liquid paraffin of the volatile oily solvent is not particularly limited, and examples thereof include light isoparaffins such as isododecane and isohexadecane, light liquid isoparaffins (a mixture of hydrocarbons having side chains obtained by copolymerizing isobutene and n-butene and then hydrogenating them), and hydrogenated polyisobutene (a type of branched aliphatic hydrogen oxide, a synthetic liquid oil mainly composed of isoparaffin). In addition, the type of volatile silicone oil of the volatile oily solvent is not particularly limited, and examples thereof include cyclic dimethyl silicone oil. In addition, the composition of the volatile liquid paraffin is not particularly limited, and it may be one type of volatile liquid paraffin or a mixture of two or more types of volatile liquid paraffins. In addition, the composition of the volatile silicone oil is not particularly limited, and it may be one type of volatile silicone oil or a mixture of two or more types of volatile silicone oils. The volatile liquid paraffin and volatile silicone oil described in this specification include both of these meanings.

[0030] In addition, the type of volatile alcohol of the volatile aqueous solvent is not particularly limited, and includes alcohols having a boiling point of about 150 degrees or less. Examples of volatile alcohols include methanol (boiling point about 64 degrees), ethanol (boiling point about 78 degrees), isopropyl alcohol (boiling point about 80 degrees), tert-butyl alcohol (boiling point about 82 degrees), allyl alcohol (boiling point about 97 degrees), 1-propanol (boiling point about 97 degrees), 1-propyl alcohol (boiling point about 97 degrees), 2-butanol (boiling point about 100 degrees), 2-methyl-2-butanol (boiling point about 102 degrees), 3-pentanol (boiling point about 116 degrees), and 1-butanol (boiling point about 118 degrees). Examples of such alcohols include 2-methoxyethanol (boiling point of approximately 124 degrees), 2-chloroethanol (boiling point of approximately 128 degrees), 3-methyl-1-butanol (boiling point of approximately 131 degrees), isoamyl alcohol (boiling point of approximately 131 degrees), isopentyl alcohol (boiling point of approximately 131 degrees), propylene glycol monoethyl ether (boiling point of approximately 133 degrees), 2-ethoxyethanol (boiling point of approximately 135 degrees), 1-pentanol (boiling point of approximately 138 degrees), and propylene glycol monopropyl ether (boiling point of approximately 150 degrees).

[0031] Furthermore, there is no particular limitation on the type of volatile ketone in the volatile aqueous solvent, and ketones having a boiling point of about 150° C. or less are included. Examples of volatile ketones include acetone (2-propanone) (boiling point of about 56°C), methyl ethyl ketone (2-butanone) (boiling point of about 80°C), methyl vinyl ketone (3-buten-2-one) (boiling point of about 81°C), methyl isopropyl ketone (3-methyl-2-butanone) (boiling point of about 93°C), diethyl ketone (3-pentanone) (boiling point of about 101°C), methyl-n-propyl ketone (2-pentanone) (boiling point of about 102°C), methyl-n-butyl ketone (2-hexanone) (boiling point of about 128°C), acetylacetone (boiling point of about 141°C), di-n-propyl ketone (boiling point of about 144°C), and ethyl-n-butyl ketone (boiling point of about 148°C).

[0032] The concentration of the volatile oily solvent is not particularly limited as long as it is within the range of 10% by weight to 90% by weight based on the total composition, but is more preferably within the range of 30% by weight to 90% by weight based on the total composition, which increases the amount of ozone dissolved in the volatile oily solvent and allows the effect of ozone to be obtained.

[0033] The concentration of the volatile aqueous solvent is not particularly limited as long as it is within the range of 10% by weight to 90% by weight based on the total composition, but is more preferably within the range of 10% by weight to 70% by weight based on the total composition, which increases the amount of ozone dissolved in the volatile oily solvent and allows the effect of ozone to be obtained.

[0034] In addition, there is no particular limitation on the mixing weight ratio (-) of the volatile oily solvent to the volatile aqueous solvent. Here, when the mixing weight ratio of the volatile oily solvent to the volatile aqueous solvent is close to 0.1, the amount of volatile oily solvent is large relative to the volatile aqueous solvent, so that the amount of solvent that dissolves ozone increases, resulting in an ozone-containing composition with high oxidizing power by ozone. On the other hand, when the mixing weight ratio of the volatile oily solvent to the volatile aqueous solvent is close to 10.0, the amount of volatile oily solvent is small relative to the volatile aqueous solvent, so that the volatile aqueous solvent promotes volatility, resulting in an ozone-containing composition with excellent volatility. When an insecticidal effect, a pest repellent effect, or an effect such as decontamination and decomposition of anticancer drugs is expected, the mixing weight ratio (-) of the volatile oily solvent to the volatile aqueous solvent is preferably, for example, within the range of 0.1 to 10.0, and more preferably within the range of 0.3 to 10.0. This allows the amount of ozone dissolved in the volatile oily solvent to be increased, and the effect of ozone can be obtained.

[0035] In addition to the above-mentioned components, volatile oil-based solvent, volatile aqueous solvent, and ozone, additives may be added to the ozone-containing composition of the present invention, provided that the effects of the present invention are not impaired. Examples of additives include oxidizing agents, reducing agents, alkaline agents, acidic agents, fragrances, solvents, dyes, stabilizers, pH adjusters, ultraviolet light inhibitors, and antioxidants.

[0036] Here, the type of additive is not particularly limited, but examples thereof include oxidizing agents such as hydrogen peroxide, manganese dioxide, and nitric acid, reducing agents such as iron (II) ions, lithium aluminum hydride, sulfite, oxalic acid, and formic acid, alkaline agents such as sodium hydroxide, acidic agents such as hydrochloric acid, non-volatile liquid paraffin, non-volatile silicone oil, cyclomethyl hydrogen silicone oil, hydrocarbons, isoparaffins, mineral spirits, acyclic hydrocarbons, cyclic hydrocarbons, halogenated hydrocarbons, ethers, esters, and carboxylic acids. Examples of acyclic hydrocarbons include pentane, hexane, heptane, octane, nonane, decane, undecane, and dodecane. Examples of cyclic hydrocarbons include cyclopentane, cyclohexane, cycloheptane, and cyclooctane. Examples of halogenated hydrocarbons include methylene chloride, ethyl chloride, chloroform, carbon tetrachloride, and trichloroethylene. Examples of ethers include dimethyl ether, diethyl ether, butyl ether, and tetrahydrofuran (THF). Examples of the ester include methyl acetate, ethyl acetate, n-butyl acetate, γ-butyrolactone, etc. Examples of the carboxylic acid include acetic acid, etc. Also, examples of the solvent include solvents containing a double bond such as isophorone and oleic acid.

[0037] In addition, there is no particular limitation on the mode of use of the ozone-containing composition according to the present invention. Here, since both the volatile oil-based solvent and the volatile aqueous solvent have high fluidity, the ozone-containing composition may be directly applied to the object, sprayed, or immersed. The ozone-containing composition may be impregnated into a cloth such as gauze and then attached to the object. Furthermore, the ozone-containing composition may be filled into an aerosol container (spray container) together with a high-pressure gas (compressed gas, liquefied gas) and used as an aerosol product. The ozone-containing composition may also be diluted and used.

[0038] Furthermore, the type of pest that is the target of the ozone-containing composition of the present invention is not particularly limited, and the composition can be applied to all pests, such as mosquitoes, mites, fleas, lice, flies, bees, horseflies, cockroaches, ants, spiders, stink bugs, etc.

[0039] In addition, the type of anticancer drug that is the target of the ozone-containing composition of the present invention is not particularly limited, and the composition can be applied to anticancer drugs in general. Examples of anticancer drugs include alkylating agents, metabolic antagonists, platinum compounds, topoisomerase inhibitors, microtubule inhibitors, and antibiotics. Examples of alkylating agents include nitrogen mustards such as cyclophosphamide, ifosfamide, busulfan, and melphalan, and nitrosoureas such as nimustine, ranimustine, carmustine, and streptozocin. Examples of metabolic antagonists include pyrimidine antagonists such as 5-fluorouracil, gemcitabine, cytarabine, and tegafur, purine antagonists such as 6-mercaptopurine, fludarabine, nelarabine, and pentostatin, and folate antagonists such as methotrexate and pemtrix sodium. Examples of platinum compounds include cisplatin, carboplatin, miriplatin, oxaliplatin, and nedaplatin. Examples of topoisomerase inhibitors include etoposide, irinotecan, nogitecan, and sobuzoxane. Examples of microtubule inhibitors include taxanes such as paclitaxel and docetaxel, vin alkaloids such as vincristine, vinblastine, and vindesi, and eribulins such as eribulin mesylate. Examples of antibiotics include anthracyclines such as doxorubicin, mitomycin, and daunomycin, actinomycin D, and bleomycin.

[0040] Next, the manufacturing apparatus and manufacturing method of the ozone-containing composition according to the present invention will be described. As shown in FIG. 1, the manufacturing apparatus 10 of the ozone-containing composition according to the present invention includes a generation section 11, a mixing tank 12, a supply section 13, and an agitator 14. The generation section 11 generates ozone. The mixing tank 12 contains both volatile solvents 12a, which are a volatile oil-based solvent and a volatile aqueous solvent. The supply section 13 blows ozone 12b into the volatile solvent 12a in the mixing tank 12. The agitator 14 stirs the volatile solvent 12a into which the ozone 12b is being blown, thereby causing the volatile solvent 12a to contain the ozone 12b.

[0041] Here, the method by which the generator 11 generates the ozone 12b can be, for example, a silent discharge method, an electrolysis method, a photoreaction method, a high-frequency electrolysis method, a solid polymer electrolysis method, etc. Also, an ozone cylinder containing the ozone 12b may be used as the generator 11 as it is.

[0042] The method of blowing in ozone 12b by the supply unit 13 can be, for example, as shown in FIG. 1, in which an end 12d of a long supply pipe 12c is placed directly on the bottom surface of the volatile solvent 12a, or an aeration pipe 12e made of a porous material that releases the enclosed gas as fine bubbles is attached to the end 12d.

[0043] The method of the agitator 14 agitating the volatile solvent 12a in the mixing tank 12 may be, for example, to rotate a predetermined agitator blade 14a at a predetermined rotation speed or to rotate an agitator using magnetic force, as in a magnetic stirrer, as shown in Fig. 1. Alternatively, the ozone 12b may be agitated and micronized by vibrating a predetermined vibrator placed in the volatile solvent 12a or irradiating the volatile solvent 12a with ultrasonic waves using a predetermined ultrasonic generator.

[0044] In addition, since the concentration of ozone 12b in the volatile solvent 12a is proportional to the blowing time of the ozone 12b, the target concentration of ozone 12b (target concentration) can usually be obtained by adjusting the blowing time (sec).

[0045] The method for producing an ozone-containing composition according to the present invention includes a mixing step of mixing a volatile oil-based solvent, a volatile aqueous solvent, and ozone in a mixing tank 12 using the above-mentioned production apparatus 10, and a stirring step of stirring the mixture in the mixing tank 12 with a predetermined stirrer 14. This makes it possible to produce the ozone-containing composition of the present invention.

[0046] Here, in addition to the above, the method for producing an ozone-containing composition according to the present invention may be, for example, a method in which ozone is contained in a volatile oily solvent in advance, and the mixing step may involve putting a volatile oily solvent containing ozone and a volatile aqueous solvent into the mixing tank 12 as a mixture and mixing the volatile oily solvent, the volatile aqueous solvent, and the ozone. Also, for example, a method in which ozone is contained in a volatile aqueous solvent in advance, and the mixing step may involve putting a volatile aqueous solvent containing ozone and a volatile oily solvent into the mixing tank 12 as a mixture and mixing the volatile oily solvent, the volatile aqueous solvent, and the ozone. Furthermore, for example, the mixing step may involve putting a volatile oily solvent and ozone into the mixing tank 12 as a mixture and mixing the volatile oily solvent and ozone, and then adding and mixing the volatile aqueous solvent. There is no particular limitation on the order of mixing the volatile oily solvent, the volatile aqueous solvent, and the ozone. EXAMPLES

[0047] Examples and comparative examples of the present invention will be described below in detail, but the application of the present invention is not limited to these examples.

[0048] (Production of ozone-containing composition) The ozone-containing composition according to the present invention was produced using the production apparatus shown in Fig. 1. As shown in the tables of Fig. 4 to Fig. 7, the components were mixed to produce the ozone-containing compositions of Examples 1-34 and Comparative Examples 1-2. The values ​​in the tables indicate the concentrations (wt%). Among the components, the concentration of ozone was set within the range of 10 ppm to 500 ppm by adjusting the blowing time.

[0049] (Evaluation method) Next, the performance of the ozone-containing composition was evaluated in the following items: (1) mosquito killing test, (2) acaricidal test, (3) anti-acaricidal test, (4) paclitaxel decontamination test, (5) 5-fluorouracil decontamination test, and (6) volatility test.

[0050] (1) Mosquito insecticidal test A glass cylinder with an inner diameter of 20 cm and a length of 43 cm was placed horizontally, one opening was blocked with a nylon mesh cloth, and the other opening was blocked with a nylon mesh cloth with sleeves. A predetermined number of mosquitoes (about 60 mosquitoes) as test pests were put into the cylinder, and an ozone-containing composition was directly sprayed from the nylon mesh cloth with sleeves toward the inside for 5 seconds. Five minutes and 60 minutes after spraying, the mosquitoes were transferred from the cylinder to a glass petri dish, and the number of dead mosquitoes was counted. The quotient obtained by dividing the number of dead mosquitoes by the number of put-in mosquitoes was calculated as the mosquito death rate (%), and the mosquitoes were ranked according to the following criteria. The evaluations of "◯" and "◎" indicate that the product is acceptable. Figure 2 shows a front photograph, a right side photograph, and a left side photograph immediately after spraying, showing an example of the results of the insecticidal test of mosquitoes in Example 1.

[0051] <Standards> ◎: When the mosquito mortality rate is 75% to 100% ○: When the mosquito mortality rate is 50% to 75% △: When the mosquito mortality rate is 25% to 50% ×: When the mosquito mortality rate is 0% to 25%

[0052] (2) Miticidal activity test 0.5mL of the ozone-containing composition liquid was evenly dropped onto a filter paper 10cm long and 5cm wide, which was then folded in half to make a size of 5cm x 5cm, and a specified number (several dozen) of live test pest mites were placed inside the folded part, and the three sides other than the fold were completely sealed with clips. After 24 hours had passed, the clips were removed, the live mites were observed under a microscope, and the number of dead live mites was counted. The quotient obtained by dividing the number of deaths by the number placed in was calculated as the mosquito mortality rate (%), and the products were ranked according to the following criteria. Products with ratings of "〇" and "◎" passed the test.

[0053] <Standards> ◎: When the mosquito mortality rate is 75% to 100% ○: When the mosquito mortality rate is 50% to 75% △: When the mosquito mortality rate is 25% to 50% ×: When the mosquito mortality rate is 0% to 25%

[0054] (3) Anti-mite test A filter paper with a diameter of 40 mm on which the liquid of the ozone-containing composition was dropped was placed in a petri dish, and 50 mg (about 250 mites) of the test pest mite rearing medium was spread in the center with a diameter of about 3 cm. In addition, a mite rearing medium was placed in an empty petri dish adjacent to the petri dish. The petri dish was immersed in saturated saline, kept at 25 degrees, and left for 24 hours. Thereafter, the movement of the mites was observed. The value obtained by dividing the diameter of the mites (mite rearing medium) after the movement by the diameter of the mites before the movement (about 3 cm) was calculated as the mite repellency rate (%), and the product was ranked according to the following criteria. The evaluations of "◯" and "◎" are acceptable products. Figure 3 is a photograph showing an example of the results of the anti-mite test in Reference Example 1 and Example 1. Reference Example 1 shows a control, which is a mixture of a volatile oily solvent and a volatile aqueous solvent that does not contain ozone. As shown in Fig. 3, in the anti-mite test, the diameter of the mites in Reference Example 1 is shown as a circle of about 3 cm, which is almost the same as the diameter of the mites before migration. On the other hand, the diameter of the mites in Example 1 is shown as a circle of 1 cm or less, which indicates that the diameter of the mites is reduced by the liquid of the ozone-containing composition that has a mite repellent effect.

[0055] <Standards> ◎: When the mite repellency rate is 0% to 25% ○: When the mite repellency rate is 25% to 50% △: When the mite repellency rate is 50% to 75% ×: When the mite repellency rate is between 75% and 100%

[0056] (4) Paclitaxel decontamination test 10μL of paclitaxel was dropped onto a stainless steel pad, which was then wiped once with a cleaning wipe soaked in 15mL of water, and then sprayed with the liquid of an ozone-containing composition or wiped once with a wipe soaked in the ozone-containing composition. Then, 250μL of an extraction solution was dropped onto the pad, and the solution was wiped off twice with filter paper. The wiped filter paper was then placed into a test tube, and the concentration (ng / mL) of the remaining paclitaxel was calculated using a liquid chromatograph mass spectrometer (LC-MS / MS), and the product was ranked according to the following criteria. The evaluations of "〇" and "◎" were acceptable products.

[0057] <Standards> ◎: When the residual paclitaxel concentration is 0.00ng / mL to 0.05ng / mL ○: When the residual paclitaxel concentration is 0.05ng / mL to 0.30ng / mL △: When the residual paclitaxel concentration is 0.30ng / mL to 0.50ng / mL ×: When the residual paclitaxel concentration is 0.50 ng / mL or more

[0058] (5) 5-fluorouracil decontamination test, (4) The same as the paclitaxel decontamination test. 10 μL of 5-fluorouracil (5-FU) was dropped onto a stainless steel pad, which was then wiped once with a cleaning wipe soaked in 15 mL of water, and then sprayed with an ozone-containing composition liquid or wiped once with a wipe soaked in an ozone-containing composition. Then, 250 μL of extraction solution was dropped onto the pad, and the solution was wiped off twice with filter paper. The wiped filter paper was then placed into a test tube, and the residual 5-FU concentration (ng / mL) was calculated using a liquid chromatograph mass spectrometer (LC-MS / MS), and ranked according to the following criteria. The products were evaluated as acceptable with "〇" and "◎".

[0059] <Standards> ◎: When the residual 5-FU concentration is 0.00ng / mL to 0.05ng / mL ○: When the residual 5-FU concentration is 0.05ng / mL to 0.30ng / mL △: When the residual 5-FU concentration is 0.30ng / mL to 0.50ng / mL ×: When the residual 5-FU concentration is 0.50 ng / mL or more

[0060] (6) Volatility test A given amount of the ozone-containing composition liquid (about 1 mL, the amount of one spray) was dropped onto a glass plate, and then the plate was kept at 25 degrees and left to stand. 10 minutes after dropping, the state of drying of the ozone-containing composition liquid was observed. The weight of the ozone-containing composition liquid after 10 minutes was divided by the amount dropped to calculate the drying rate (%), and the product was ranked according to the following criteria. Evaluations of "◯" and "◎" are acceptable products.

[0061] <Standards> ◎: Drying rate is 0% to 25% ○: When the drying rate is 25% to 50% △: Dryness rate is 50% to 80% ×: Drying rate is 80% to 100%

[0062] (Evaluation Results) When the evaluation results are checked, as shown in Fig. 4, in Comparative Example 1, although a volatile oily solvent and ozone are contained, a volatile aqueous solvent is not contained, so the ozone does not properly contact the trachea of ​​pests or the anticancer drug, and the evaluation results of (1) mosquito killing test, (2) acaricidal test, (3) anti-mite test, (4) paclitaxel decontamination test, and (5) 5-fluorouracil decontamination test are all "△", and the product is unsatisfactory. In addition, in Comparative Example 2, although a volatile aqueous solvent and ozone are contained, a volatile oily solvent is not contained, so the ozone itself is not dissolved in the liquid, and the evaluation results of (1) mosquito killing test, (2) acaricidal test, (3) anti-mite test, (4) paclitaxel decontamination test, and (5) 5-fluorouracil decontamination test are all "X", and the product is unsatisfactory.

[0063] On the other hand, in Examples 1-7, when the concentrations of the volatile oily solvent and the volatile aqueous solvent were within a specific concentration range, the evaluation results of (1) mosquito killing test, (2) acaricidal test, (3) anti-acaricidal test, (4) paclitaxel decontamination test, and (5) 5-fluorouracil decontamination test were "good" or "good". (6) The evaluation result of the volatility test was "good" or "good", and the product passed the test.

[0064] Next, as shown in FIG. 5, in Examples 8-16, even when the type of volatile oily solvent was any one of light isoparaffin, light liquid isoparaffin, hydrogenated isobutene, cyclic dimethyl silicone oil, or a mixture of these, the evaluation results of (1) mosquito killing test, (2) acaricidal test, (3) anti-acaricidal test, (4) paclitaxel decontamination test, and (5) 5-fluorouracil decontamination test were "◎", and the evaluation result of (6) volatility test was "◯", indicating that the product passed the test.

[0065] Furthermore, as shown in FIG. 6, in Examples 17-27, even when the type of volatile aqueous solvent was either a volatile alcohol (isopropanol, ethanol, 1-pentanol), a volatile ketone (acetone, methyl ethyl ketone, 2-hexanone), or a mixture of these, the evaluation results of (1) mosquito killing test, (2) acaricidal test, (3) anti-acaricidal test, (4) paclitaxel decontamination test, and (5) 5-fluorouracil decontamination test were all "◎", and the evaluation result of (4) volatility test was "◯", indicating that the product passed the test.

[0066] Furthermore, as shown in FIG. 7, in Examples 28-34, even when a volatile oil-based solvent, a volatile aqueous solvent, and ozone were contained, and further, any of hydrogen peroxide, an alkaline agent (sodium hydroxide), an acidic agent (hydrochloric acid), fragrances, and colorants were added as additives, the evaluation results of (1) mosquito killing test, (2) acaricidal test, (3) anti-acaricidal test, (4) paclitaxel decontamination test, and (5) 5-fluorouracil decontamination test were "◎", and the evaluation result of (4) volatility test was "◯", indicating that the products passed the test. [Industrial Applicability]

[0067] As described above, the ozone-containing composition and the method for producing an ozone-containing composition according to the present invention are useful not only in the fields of insecticide and pest repellent, and decontamination and decomposition of anticancer drugs, but also in the fields of hygiene, medicine, agriculture, dairy farming, etc., and are effective as an ozone-containing composition and a method for producing an ozone-containing composition that have insecticidal effects, pest repellent effects, decontamination and decomposition of anticancer drugs, etc., are safe for the human body, and can facilitate post-treatment after application. [Explanation of symbols]

[0068] 10 Manufacturing equipment 11. Generator 12 Mixing tank 12a Volatile Solvents 12b Ozone 13 Supply section 14 Mixer

Claims

1. A volatile oily solvent, which is one or more volatile liquid paraffins selected from the group consisting of light isoparaffin, light liquid isoparaffin, and hydrogenated polyisobutene, a volatile silicone oil including cyclic dimethyl silicone oil, or a mixture thereof, and has a concentration in the range of 10% by weight to 90% by weight based on the total composition; a volatile aqueous solvent, which is a volatile alcohol, a volatile ketone, or a mixture thereof, in a concentration ranging from 10% to 90% by weight of the total composition; Ozone and An ozone-containing composition comprising:

2. The concentration of the volatile oily solvent is within the range of 30% to 90% by weight based on the total composition; The concentration of the volatile aqueous solvent is within the range of 10% to 70% by weight based on the total composition; 2. The ozone-containing composition of claim 1.

3. The ozone-containing composition further contains any one of an oxidizing agent, a reducing agent, an alkaline agent, and an acidic agent as an additive.

2. The ozone-containing composition of claim 1.

4. A volatile oily solvent, which is one or more volatile liquid paraffins selected from the group consisting of light isoparaffin, light liquid isoparaffin, and hydrogenated polyisobutene, a volatile silicone oil including cyclic dimethyl silicone oil, or a mixture thereof, and has a concentration in the range of 10% by weight to 90% by weight based on the total composition; a volatile aqueous solvent, which is a volatile alcohol, a volatile ketone, or a mixture thereof, in a concentration ranging from 10% to 90% by weight of the total composition; Ozone and a mixing step of mixing the above in a predetermined mixing tank; a stirring step of stirring the mixture in the mixing tank with a predetermined stirrer; A method for producing an ozone-containing composition comprising the steps of:

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