Liquid measuring device and method for determining efficacy of crude drug using liquid measuring device

Abstract

To provide means for determining the efficacy of a crude drug in a determination object of the same kind by electrically measuring the determination object.SOLUTION: In order to determine whether or not a crude drug of a determination object of the same kind is effective, the activity of its extract is electrically measured. The determination object for determining the efficacy of the crude drug is extracted according to a determination procedure for determining the efficacy of the crude drug prepared for each kind of the determination object, a liquid 9 to be determined is prepared, first and second electrodes 4 and 5 of a voltage or current detection unit are housed in an electrode device 2 using the same conductor for oxidation-reduction reaction relating to the liquid 9 to be determined after being sufficiently cooled and fermented, and the fluctuation of a voltage or current generated between the first and second electrode terminals 6 and 7 is measured and recorded by a measurement and recording device 3 by using characteristics of waves possessed by electrons. The measured record is compared with the efficacy determination standard of the crude drug derived from a measurement result of the determination object of the same kind, and the presence or absence of the efficacy of the crude drug is determined depending on whether or not the standard for determining the efficacy of the crude drug is satisfied.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to determining whether or not herbal medicines in foods, Chinese medicines, and other ingestible objects have efficacy. [Background technology]

[0002] There are two types of herbal medicines: those that are registered in the Japanese Pharmacopoeia as Kampo medicines and treated as medicines under the Pharmaceuticals and Medical Devices Act, and those that are not registered and are treated as foods, beverages, etc. In the case of the former, the General Provisions for Herbal Medicines and the Testing Methods for Herbal Medicines of the Japanese Pharmacopoeia are applied, and the methods of determination are various component testing methods such as smell, taste, microscopic examination, and chromatography methods described in the Testing Methods for Herbal Medicines. In the case of the latter, when sold as ordinary foods, etc., there is no particular provision for determining the efficacy of herbal medicines, but the methods for examining their components are the same as the former. [Prior art documents] [Non-patent literature]

[0003] [Non-Patent Document 1] Ministry of Health, Labor and Welfare, 18th Edition of the Japanese Pharmacopoeia Summary of the Invention [Problem to be solved by the invention]

[0004] However, there was a case where some tumors shrank when tea produced by the inventor was used. For this reason, the inventor looked into the efficacy of herbal medicines in tea and how to determine them, but there were only books and papers about the classics of botany and the ingredients of tea, and no books or papers explaining the reasons for differences in the efficacy of herbal medicines in tea produced in the same place or how to determine them. Furthermore, if there was a clear method for determining the efficacy of herbal medicines in such foods, beverages, Chinese medicines, and other ingestible objects (hereinafter referred to as objects to be determined), tea would be registered in the Japanese Pharmacopoeia and the determination method and production method would be established, but there is no such reality at all, and tea only has advertisements on the street claiming that it is good for health. There are many similar cases in other objects to be determined, and the effects are touted, but the scientific basis is to identify the ingredients and their amounts through ingredient analysis using various chromatographic methods, and there is no method to clearly determine the difference in the efficacy of herbal medicines in the same type of objects to be determined.

[0005] Therefore, the object of the present invention is to provide a method for determining the efficacy of herbal medicines by electrically measuring the activity state of an extract extracted from an object to be evaluated using the device and method for determining the efficacy of herbal medicines, even if the object to be evaluated is the same type and produced in the same place. [Means for solving the problem]

[0006] The method for determining the efficacy of herbal medicine of the present invention is a method for determining whether or not the herbal medicine is effective from the electrical activity state of the object to be determined, and is characterized in that the object to be determined is extracted to create a liquid 9 to be determined, and the voltage or current generated from the created liquid 9 to be determined is measured using a liquid measuring device 1 to determine whether or not the herbal medicine in the object to be determined is effective.

[0007] The liquid measuring device 1 for determining whether or not a herbal medicine of the present invention is effective is a device that measures the activity of a liquid 9 to be evaluated, which contains an extract extracted from an object to be evaluated, by utilizing the wave properties of electrons, and is characterized by comprising an electrode device 2 that generates an oxidation-reduction reaction when the liquid 9 to be evaluated is contained in the electrode device 2, and a measurement and recording device 3 that measures and records the voltage or current generated from the electrode device 2 when it contains the liquid 9 to be evaluated.

[0008] The electrode device 2 is characterized by having first and second electrodes 4 and 5 having surfaces made of the same conductor that undergoes an oxidation-reduction reaction with the liquid 9 to be evaluated, and having a first electrode terminal 6 electrically connected to the first electrode 4 and a second electrode terminal 7 electrically connected to the second electrode 5, which transmit the fluctuation of electrons due to the oxidation-reduction reaction that occurs when the liquid 9 to be evaluated is contained therein to the measurement and recording device 3.

[0009] The first and second electrodes 4 and 5 of the electrode device 2 are plate-like and of the same shape, arranged with their largest flat surfaces facing and parallel to each other, and are characterized in that when voltage or current measurement begins, all surfaces of the first and second electrode terminals 6 and 7 except for the connection surfaces, corners, or points of the first and second electrodes 4 and 5 and the opposite surfaces, corners, or points thereof come into contact with the liquid 9 to be evaluated.

[0010] The first and second electrode terminals 6 and 7 of the electrode device 2 are electrically connected to the first and second electrodes 4 and 5, respectively, through a plug 8 which is an insulator. The plug 8 and container 10 are shaped so as to be able to contain the liquid 9 to be evaluated without any air bubbles at the start of measurement, and the depths 16 of the first and second electrodes 4 and 5 relative to the liquid to be evaluated at the start of measurement are the same for both electrodes.

[0011] As for the preferred arrangement and shape of the first and second electrodes 4 and 5 of the electrode device 2, the thickness 14 of the first and second electrodes is preferably as thin as possible while maintaining its shape, and is preferably less than twice the distance 15 between the first and second electrodes. The distance is preferably as small as possible while the space between the first and second electrodes 4 and 5 is filled with the liquid 9 to be measured, and the volume 17 between the first and second electrodes is preferably less than half the outer volume 18 of the largest plane where the first and second electrodes face each other. The area 19 of the largest plane where the first and second electrodes face each other is preferably as large as possible as long as it does not come into contact with the container 10, and although the shape is shown as a rectangle in the drawing for convenience, it may be a square, circle, ellipse, oval, etc.

[0012] The method of the present invention for determining the efficacy of herbal medicines using a liquid measuring device 1 is characterized in that it creates a liquid 9 to be determined from the object to be determined in accordance with a procedure for determining the efficacy of herbal medicines created for each type of object to be determined, contains the liquid 9 to be determined in an electrode device 2, measures and records the voltage or current generated by the electrode device 2 with a measurement and recording device 3, and compares the measurement record with an efficacy determination standard for herbal medicines created for each type of object to be determined to determine the activity state of the object to be determined and determine whether or not the herbal medicine is effective.

[0013] The measurement and recording device 3 used in the liquid measuring device 1 is composed of a measuring device 11 and a recording device 12. The measurement and recording used to determine the efficacy of the herbal medicine of the subject to be evaluated is performed by recording the fluctuations in voltage or current generated by the oxidation-reduction reaction between the liquid 9 to be evaluated, which contains the extract extracted from the subject to be evaluated, and the conductors used for the first and second electrodes 4 and 5, for a specified time at intervals specified for each type of subject to be evaluated, without applying a voltage to the first and second electrode terminals 6 and 7. Therefore, the measurement and recording device 3 must satisfy the conditions of the measurement and recording interval and measurement and recording time specified for the subject to be measured, and there must be no current leakage from the measurement terminal connected to the electrode device 2 of the measuring device 11 to the electrode device 2.

[0014] When the efficacy of the herbal medicine cannot be confirmed by the method for determining efficacy of the herbal medicine using the liquid measuring device 1, if the procedure for determining efficacy of the herbal medicine created for each type of object to be determined specifies a method for determining efficacy of the herbal medicine using the electrode device 2, the presence or absence of efficacy of the herbal medicine can be determined using the electrode device 2. In this case, the method for determining efficacy of the herbal medicine using the electrode device 2 is characterized in that the liquid 9 to be determined is placed in the electrode device 2 and left to stand according to the procedure for determining efficacy of the herbal medicine created for each type of object to be determined, and the precipitate that precipitates inside the electrode device 2 and on the surfaces of the first and second electrodes 4 and 5 after a specified time has elapsed is compared with the efficacy criteria for the herbal medicine created for each type of object to be determined to determine the presence or absence of efficacy of the herbal medicine.

[0015] The procedure for determining efficacy of a herbal medicine is a procedure for determining the presence or absence of efficacy of a herbal medicine in all determination objects of the same type as the determination object for which the efficacy of the herbal medicine has been confirmed, which is created for the determination object for which the efficacy of the herbal medicine has been confirmed, and includes a procedure for creating the determination object liquid 9, which includes designation of the shape of the electrode device 2 used for measurement and the conductor to be used for the first and second electrodes 4 and 5, a method for extracting the determination object into the determination object liquid 9 and the extraction time and the static fermentation time of the extracted determination object liquid 9, a measurement procedure including a measurement method, measurement time and measurement recording interval when measuring the determination object liquid 9 created in the determination object liquid 9 creation procedure with the liquid measuring device 1, and an observation procedure including a method and a static fermentation time of the electrode device 2 containing the determination object liquid 9 after the measurement is completed, or an unused electrode device 2 containing a newly created determination object liquid 9. 、 Standards for determining efficacy of herbal medicines and measurement records and / or Five steps of the judgment procedure to judge the efficacy of the herbal medicine of the judgment object by comparing the state of the electrode device 2 Two or more of the following: The present invention is characterized by the following:

[0016] The efficacy evaluation procedure for the herbal medicine is created together with the efficacy evaluation criteria for the herbal medicine. When creating an efficacy evaluation procedure for a herbal medicine for which efficacy evaluation criteria for the herbal medicine have not been established and an efficacy evaluation procedure for a herbal medicine for which efficacy evaluation criteria for the herbal medicine have not been established, it is necessary to find a procedure that is likely to clearly show a difference in the measurement records to be adopted as the efficacy evaluation criteria for the herbal medicine by adjusting the shape of the electrode device 2, the conductor used for the first and second electrodes 4 and 5, the method and extraction time of extracting the subject of evaluation in the liquid 9 to be evaluated, the static fermentation method and static fermentation time of the liquid 9 to be evaluated from which the subject of evaluation has been extracted, and the measurement time and measurement record interval when the liquid 9 to be evaluated is contained in the liquid measuring device 1 and measured, until a clear difference in the measurement records is generated by measuring multiple subjects produced at the same production site and by the same production method, including the subject of evaluation for which efficacy evaluation criteria for the herbal medicine have not been established, and to find a procedure that is likely to clearly show a difference in the measurement records to be adopted as the efficacy evaluation criteria for the herbal medicine. In addition, it may be necessary to create a procedure for evaluating the efficacy of the herbal medicine by static observation of the electrode device 2 separately from the procedure for evaluating the efficacy of the herbal medicine by measurement records.

[0017] The method of preparing the liquid 9 to be evaluated in the procedure for evaluating the efficacy of herbal medicines is to select the type of solvent and container for extracting the substance to be evaluated, and if the substance to be evaluated is a beverage that has been extracted from the raw materials and subjected to watering and heating treatment, it is left as is, if it is a solid, the substance to be evaluated is boiled and extracted in the solvent placed in the selected container, and if it is a highly viscous liquid, it is diluted with the selected solvent to produce the liquid 9 to be evaluated. In this case, the solvent and container for extracting the substance to be evaluated that are the source of the liquid 9 to be evaluated must take into consideration the characteristics of the conductors used for the first and second electrodes 4 and 5, as can be seen from Figures 10 and 13.

[0018] The efficacy judgment criteria for the herbal medicine are criteria for judging the efficacy of the herbal medicine for all judgment objects of the same type as the judgment object for which the efficacy of the herbal medicine has been confirmed, which are created for the judgment object for which the efficacy of the herbal medicine has been confirmed, in the same manner as the procedure for judging the efficacy of the herbal medicine. The judgment is made by comparing the measurement records of multiple judgment objects of the same place of origin and the same manufacturing method, including the judgment object for which the efficacy of the herbal medicine has been confirmed, with multiple measurement records of the same type of judgment object for which the efficacy of the herbal medicine has not been confirmed, and the threshold voltage or current for each elapsed time derived from the difference other than the positive or negative voltage or current and the variable conditions of the voltage or current. and / or This device is characterized by being able to determine the efficacy of herbal medicine based on the presence or absence of precipitates other than the liquid to be evaluated 9 and the generated gas on the surfaces of the first and second electrodes 4 and 5 and inside the electrode device 2 after a specified time has elapsed.

[0019] The procedure for determining the efficacy of herbal medicines and the criteria for determining the efficacy of herbal medicines need to be created for each type of object to be evaluated, since the type of conductor that reacts and the tendency to generate voltage or current vary depending on the type of object to be evaluated.

[0020] The method for evaluating efficacy of herbal medicines in tea according to the present invention, which is based on the procedure for evaluating efficacy of herbal medicines in tea by measuring and recording using a liquid measuring device 1, comprises the steps of: boiling and extracting tea to be evaluated in water for 10 minutes in an electrically insulating container, and then electrically insulating the tea for 24 hours and thoroughly cooling and fermenting the tea to be evaluated to prepare a liquid 9 to be evaluated; storing the prepared liquid 9 to be evaluated in an electrode device 2 using copper for the first and second electrodes 4 and 5, and measuring and recording the liquid 9 at 1 second intervals for 48 hours using the liquid measuring device 1; after the measurement is completed, comparing the measurement record measured by the liquid measuring device 1 with the efficacy evaluation criteria for herbal medicines in tea to determine whether the criteria for efficacy of the herbal medicines are met.

[0021] The procedure for determining the efficacy of herbal tea by observing the electrode device 2 based on the procedure for determining the efficacy of herbal tea described above involves preparing the liquid 9 to be evaluated by the electrode device 2 after the procedure for determining the efficacy of herbal tea by measuring and recording using the liquid measuring device 1 has been completed, or preparing a new liquid 9 to be evaluated by boiling and extracting the tea to be evaluated in water for 10 minutes in an electrically insulating container, and then leaving it in an electrically insulated state for 24 hours and sufficiently cooling and fermenting it, and then storing the prepared liquid 9 to be evaluated in the electrode device 2 using copper for the first and second electrodes 4 and 5, electrically shorting the first and second electrode terminals 6 and 7, and leaving it to stand for 14 days before observing it. The observed state of the electrode device 2 is compared with the efficacy criteria for tea herbal medicines, and if the criteria for determining whether the herbal medicine has efficacy are met, the tea to be evaluated is extracted by boiling in water for 10 minutes in an electrically insulating container, and then the tea is electrically insulated for 24 hours and sufficiently cooled and fermented to prepare a liquid to be evaluated 9, which is then placed in electrode device 2 using aluminum for the first and second electrodes 4 and 5, and the first and second electrode terminals 6 and 7 are electrically short-circuited. The liquid is then allowed to stand for 96 hours, after which it is observed and compared with the efficacy criteria for tea herbal medicines.

[0022] The shape of the first and second electrodes 4 and 5 of the electrode device 2 when the procedure for evaluating the efficacy of tea herbal medicines was created was characterized by the first and second electrodes 4 and 5 having a rectangular surface measuring 60 mm in length and 10 mm in width, and 0.3 mm in thickness, arranged in parallel at intervals of 1 mm, as shown in Figure 6.

[0023] The method for determining the efficacy of tea herbs using the above-mentioned procedure for determining the efficacy of tea herbs involves repeating the procedure for determining the efficacy of tea herbs by measurement and recording using a liquid measuring device 1 ten or more times using a liquid measuring device 1 with an electrode device 2 of the same shape to derive a detection rate for the presence or absence of efficacy of the herbs, and if the procedure for determining the efficacy of tea herbs by measurement and recording using the liquid measuring device 1 does not determine that the herbs are effective, the procedure for determining the efficacy of tea herbs by observation using the electrode device 2 is used to determine the presence or absence of efficacy of the tea herbs to be determined, and it is possible to estimate from the detection rate how much tea with the efficacy of herbs is produced in the area where the tea to be determined is produced.

[0024] The criteria for determining the efficacy of tea herbs used in the procedure for determining the efficacy of tea herbs, which is based on measurements and records using liquid measuring device 1, is characterized in that the tea being evaluated is determined to have the efficacy of herbs when the voltage converges to within ±10 mV for about an hour 24 hours after the start of measurement, or when the voltage remains within ±10 mV from before 24 hours after the start of measurement to after 24 hours, and then exceeds ±10 mV.

[0025] The criterion for judging the efficacy of herbal tea used in the procedure for judging the efficacy of herbal tea, which is based on observation of the electrode device 2, is characterized in that, when the liquid 9 to be judged is placed in the electrode device 2 using copper for the first and second electrodes 4 and 5, no mold is found between the liquid 9 to be judged and the generated bubbles, and, when the liquid 9 to be judged is placed in the electrode device 2 using aluminum for the first and second electrodes 4 and 5, the generation of reddish-brown precipitates is confirmed on the first and second electrodes 4 and 5, thereby judging that the tea to be judged has the efficacy of herbal medicine.

[0026] The method for evaluating the efficacy of herbal medicines in tea using the procedure for evaluating the efficacy of herbal medicines in tea and the criteria for evaluating the efficacy of herbal medicines in tea described above has the following work procedure. Tea to be evaluated is prepared from the same production site and manufacturing method for an appropriate number of measurements, and is measured and recorded 10 times or more using the liquid measurement device 1 using the electrode device 2 of the same shape in the procedure for evaluating the efficacy of herbal medicines in tea by measuring and recording using the liquid measurement device 1 described above. The measurement records are compared with the criteria for evaluating the efficacy of herbal medicines in tea by measuring and recording using the liquid measurement device 1 to derive the number of measurement records that are evaluated as having the efficacy of herbal medicines, and this number is divided by the number of measurements to derive the detection rate of tea with herbal medicine efficacy. If there are zero measurement records that are evaluated as having the efficacy of herbal medicines, it is possible to estimate how much tea has the efficacy of herbal medicines in the place where the evaluation target tea is produced by comparing with the criteria for evaluating the efficacy of herbal medicines in tea by observing the electrode device 2 in the procedure for evaluating the efficacy of herbal medicines in tea by observing the electrode device 2 to determine whether there is a detection rate of less than 1 / the number of measurements. The procedure for evaluating the efficacy of herbal tea can be illustrated in the flowcharts shown in FIGS. Effect of the Invention

[0027] Although there has been a method for determining the efficacy of crude drugs from the types and amounts of components of the object to be determined, there has been no determination method regarding the activity of the object to be determined. In this method, it is possible to measure and compare the fluctuations of electrons generated from the amount of electricity held by the object to be determined, and to determine the presence or absence of the efficacy of crude drugs for a plurality of objects to be determined of the same type, even if the objects to be determined are produced in the same origin and by the same manufacturing method, based on the precipitates generated by the fluctuations of electrons.

[0028] The main tests for crude drugs used in medicine require facilities that are impossible to implement even in a laboratory and are very time-consuming. However, with this invention, anyone can conduct a determination experiment anywhere as long as they have a metal plate, a glass cup, a lid, a Horii medicine pot for boiling and extracting the object to be determined, a measuring instrument capable of recording, electrodes, and tools for processing the lid. Also, since the required power is only about the power of the measurement recording device 3 and does not require a large power source, it is possible to carry it around and conduct determination work at the production site of the object to be determined, except for the heat source for boiling water.

Brief Description of the Drawings

[0029] [Figure 1] It is a schematic diagram of the liquid measuring device according to the present invention. [Diagram 2] It is a detailed diagram showing the configuration of the liquid measuring device according to the present invention. [Diagram 3] It is a cross-sectional view showing the shape of the electrode device according to the present invention. [Figure 4] It is a cross-sectional view showing the shape of the electrode device according to the present invention. [Diagram 5] It is a cross-sectional view showing the shape of the electrode device according to the present invention. [Figure 6] It is a triangular diagram showing the dimensions and shape of the electrode portion of the electrode device created and used during the development according to the present invention. [Figure 7] It is an example of comparison of measurement records of the same type of food in which the efficacy of crude drugs has been confirmed and not confirmed according to the present invention. [Figure 8]This is a graph comparing the measurement records by harvest date of tea harvested in 2019 in the same field as the tea in which the efficacy of herbal medicine was confirmed. [Figure 9] This is a graph comparing the measurement records of commercially available teas for which the efficacy of herbal medicines has not been confirmed. [Figure 10] This is a graph showing the measurement and recording of water using a copper electrode as an example of a liquid containing no herbal ingredients. [Figure 11] 1 is an example of the difference in the measurement results of different foods having the efficacy of the herbal medicine according to the present invention using a copper electrode. [Figure 12] 1 is an example of the difference in measurement results depending on the type of conductor used in the electrode according to the present invention. [Figure 13] This is a graph showing the measurement and recording of water using an aluminum electrode as an example of a state in which there are no herbal ingredients in the liquid. [Figure 14] This is a comparative graph showing the measurements and records made with aluminum electrodes of tea and a herbal medicine whose main ingredients are Ganoderma lucidum and Kawaratake mushrooms, and whose efficacy has been confirmed as being different from that of other herbal medicines produced in different years. [Figure 15] This shows the deposition of a voltage source on the surface of an aluminum electrode when measuring tea for which the efficacy of herbal medicines was confirmed. [Figure 16] This shows the difference between copper electrodes measuring tea with confirmed herbal efficacy and tea without confirmed herbal efficacy. [Figure 17] 1 is a flowchart showing the efficacy evaluation of herbal tea using copper electrodes. [Figure 18] 13 is a flowchart for determining efficacy of herbal tea using an aluminum electrode when efficacy cannot be determined using a copper electrode. [Figure 19] This is a measurement record using a cylindrical copper electrode for tea, where the efficacy of herbal medicine has been confirmed. [Figure 20] This is a measurement record using an irregularly shaped copper electrode for tea, where the efficacy of herbal medicine has been confirmed. [Figure 21] This is a comparison graph of the measurement records using a copper electrode for tea brewed normally using tea with confirmed herbal efficacy and commercially available tea with no confirmed herbal efficacy. [Figure 22]This is a comparison graph of the measurement records using a copper electrode for tea with confirmed herbal efficacy and commercially available tea with no confirmed herbal efficacy, both boiled for 10 minutes. [Diagram 23] This is a comparison graph of measurement records using a commercially available aluminum electrode for green tea. [Figure 24] This is a comparison graph of measurement records using an aluminum electrode for tea harvested on May 20th, when the efficacy of the herbal medicine was confirmed, and commercially available bancha tea. [Diagram 25] This is a comparison graph of measurement records using aluminum electrodes for commercially available bottled green tea and commercially available black tea. [Figure 26] This is an exceptional case among the voltage measurement records using copper electrodes for commercially available tea, where the efficacy of herbal medicines has not been confirmed. [Figure 27] This is an example of an interpretation of an exceptional case among voltage measurement records using copper electrodes for commercially available tea, where the efficacy of herbal medicines has not been confirmed. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0030] A preferred embodiment of the present invention will now be described with reference to the drawings.

[0031] Fig. 1 shows an outline of how to use the liquid measuring device 1 in the method for determining the efficacy of herbal medicines of the present invention. The liquid measuring device 1 is a device that measures and records the fluctuation of electrons generated from the liquid 9 to be determined, and is composed of an electrode device 2 and a measurement and recording device 3. When determining the efficacy of the herbal medicine from the measurement and record using the liquid measuring device 1, the electrode device 2 containing the liquid 9 to be determined is used in a connected state to the measurement and recording device 3 when measuring the voltage or current, and when determining the efficacy of the herbal medicine from the state of the electrode device 2, the first and second electrode terminals 6 and 7 of the electrode device 2 containing the liquid 9 to be determined are electrically shorted with a lead wire with an alligator clip or the like and the electrode device 2 is used alone.

[0032] FIG. 2 shows a detailed diagram of the configuration of the liquid measuring device 1 according to the present invention. The activity of the extract in the liquid 9 to be determined, which is created from the object to be determined, is determined by measuring the fluctuation in voltage or current between the first and second electrodes 4 and 5, which occurs from the redox reaction between the liquid 9 to be determined and the first and second electrodes 4 and 5, utilizing the wave characteristics of electrons. Therefore, the plug 8 and container 10 for containing the liquid 9 to be determined are electrically insulating, and the first and second electrodes 4 and 5 are conductors of the same material that react with the liquid 9 to be determined corresponding to the object to be determined and that react with the liquid 9 to be determined. The first and second electrodes 4 and 5 are electrically connected to the first and second electrode terminals 6 and 7 through the plug 8, respectively, and when the liquid measuring device 1 is in use, they are electrically connected to the measuring terminal of the measuring device 11 by a lead wire with an alligator clip or the like. The measuring device 11 is connected to a recording device 12 by a signal cable or the like 13, and records the measured values ​​at regular intervals. For this reason, a computer or the like with sufficient recording capacity should be used for the recording device 12, and there should be no current leakage from the measurement terminal of the measuring device 11 to the electrode device 2. For convenience, the measuring device 11 is shown as a voltmeter in Figures 1 and 2, but it may also be an ammeter. Also, a measurement and recording device 3 in which the measuring device 11 and the recording device 12 are integrated may be used.

[0033] 3, 4 and 5 show the shape of the electrode device 2 according to the present invention. The first and second electrodes 4 and 5, which are voltage or current detection parts, have a shape in which all surfaces except the connection surfaces, corners, or points with the first and second electrode terminals 6 and 7 and the opposite surfaces, corners, or points are in contact with the liquid 9 to be determined, and have surfaces made of the same conductor that undergoes an oxidation-reduction reaction with the liquid 9 to be determined. The first and second electrodes 4 and 5 are plate-shaped with the same shape, and are shaped so that their largest flat surfaces face each other and are arranged parallel to each other. The thickness 14 of the first and second electrodes is preferably as thin as possible while maintaining the shape of the electrodes during use, and is preferably less than twice the thickness of the distance 15 between the first and second electrodes. The depth 16 of the first and second electrodes 4 and 5 with respect to the liquid to be determined is the same for both the first and second electrodes 4 and 5 at the start of measurement. The gap 15 between the first and second electrodes is preferably as narrow as possible so that the liquid 9 to be measured fills the gap between the first electrode 4 and the second electrode 5 without any air bubbles at the start of measurement, and the volume 17 between the first and second electrodes is preferably less than half the volume 18 outside the planes of the first and second electrodes facing each other. The area 19 of the planes of the first and second electrodes facing each other is preferably as large as possible as long as it does not contact the container 10. The first and second electrode terminals 6 and 7 are electrically connected to the first and second electrodes 4 and 5, and the plug 8 that fixes them has a structure that allows the liquid 9 to be measured to be contained in the container 10 without any air bubbles at the start of measurement and is electrically insulating. The gap between the first and second electrode terminals 6 and 7 must be electrically insulated before the liquid 9 to be measured is contained in the electrode device 2. In FIG. 4, the largest plane of the first and second electrodes 4 and 5 is illustrated as a rectangle for convenience, but it may be any shape such as a square, circle, ellipse, or oval. FIG. 6 shows a dimensional drawing of an electrode that was prepared and used during the development of the present invention as an example of an electrode.

[0034] As an example of a method for assessing the efficacy of herbal medicines using the liquid measuring device 1 of the present invention, a comparison example is shown in FIG. 7 where the measurement records of tea having herbal medicine efficacy and the measurement records of tea having no confirmed herbal medicine efficacy are assessed based on the efficacy assessment criteria for herbal tea. Figure 7 is a graph comparing the voltage measurements of tea using the liquid measuring device 1. When copper is used for the first and second electrodes 4 and 5 of the electrode device 2 in the case of tea, as shown in Figure 7, the activity of the extract in the liquid being evaluated 9 is strong, and the efficacy of the herbal medicine is confirmed in the record 20 using the copper electrodes of tea, in which the efficacy of the herbal medicine is confirmed, is shown to gradually increase immediately after the start of measurement, compared to the record 21 using the copper electrodes of tea, in which the efficacy of the herbal medicine is not confirmed. Between 30 and 32 hours, which is 24 hours after the start of measurement, the voltage converges to within the range of ±10mV for more than an hour, and then generates a large voltage exceeding ±10mV for a long period of time, satisfying the condition that the voltage converges to within ±10mV for more than an hour after 24 hours, as shown in the range 22 of the efficacy of the herbal medicine in tea when copper electrodes are used for the first and second electrodes 4 and 5.

[0035] As an example of the procedure for assessing the efficacy of herbal medicines and the method for creating the efficacy assessment criteria for herbal medicines in the above-mentioned method for assessing the efficacy of herbal medicines, comparison graphs and photographs of measurement records when verifying the procedure for assessing the efficacy of herbal medicines for tea and the efficacy assessment criteria for herbal medicines for tea are shown in Figures 8 to 18, and the configuration of the work required for the procedure for assessing the efficacy of herbal medicines and the method for creating the efficacy assessment criteria for herbal medicines are described below.

[0036] First, Fig. 8 shows a graph comparing the measurement records by harvest date of tea harvested in the same field as the tea with confirmed herbal efficacy, Fig. 9 shows a graph comparing the measurement records of commercially available tea with no confirmed herbal efficacy, and Fig. 10 shows measurement graphs of five types of water as representatives of a state in which there are no herbal ingredients in the liquid 9 to be judged. An electrode device 2 using copper for the first and second electrodes 4 and 5 is used for the measurement. Fig. 8 shows 23 records of tea harvested in 2019 harvested in the same field as the tea with confirmed herbal efficacy, and in four of the 23 records, there was no discharge exceeding ±10mV until 24 hours had passed after the start of measurement, or the voltage was within ±10mV for more than one hour 24 hours after the discharge from the start of measurement ended, and then the voltage exceeded ±10mV. Fig. 9 shows measurement records of randomly selected commercially available tea with no confirmed herbal efficacy, and in all cases the voltage generated after 24 hours had passed after the start of measurement was less than ±10mV. Figure 10 shows the records of tap water boiled in an iron kettle at 8.5 pH, tap water boiled in an enamel container at 8.0 pH, purified water at 8.0 pH, purified water with its acidity adjusted with citric acid at 5.0 pH, and purified water with its acidity adjusted with citric acid at 2.7 pH, and in all cases no voltage exceeding ±10 mV was generated immediately after the start of measurement. From these measurements, it can be seen that when using copper for the first and second electrodes 4 and 5 to determine whether or not the herbal medicines in tea have any efficacy, the clear difference in the voltage generated at or after 24 hours after the start of measurement can be used as the criterion for determining whether or not the herbal medicines are effective.

[0037] Next, FIG. 11 shows an example of a measurement graph when verifying the generated voltage in two different objects to be judged for which the efficacy of herbal medicines was confirmed. FIG. 11 is a graph comparing the measurement record of tea for which the efficacy of herbal medicines was confirmed with the measurement record of a herbal medicine made mainly of Ganoderma lucidum and Kawaratake mushroom. Record 23, which uses the copper electrode of the herbal medicine made mainly of Ganoderma lucidum and Kawaratake mushroom for which the efficacy of herbal medicines was confirmed, does not discharge significantly within 24 hours after the start of measurement, binds electrons, and generates a large voltage of nearly 100 mV after 32 hours has passed, compared to record 20, which uses the copper electrode of tea for which the efficacy of herbal medicines was confirmed. The generation of a voltage exceeding ±10 mV after 24 hours from the start of measurement is a guideline for determining whether or not the herbal medicines are effective, but it can be seen that the tendency of voltage generation differs depending on the type of object to be judged. In addition, it can be seen from the graph that the voltage generated immediately after the start of measurement is small, and that objects with strong electron binding power at the beginning of measurement tend to have the efficacy of herbal medicines.

[0038] Next, we will verify the difference due to the difference in the conductor used for the first and second electrodes 4 and 5. Figure 12 compares the record 20 of tea in which the efficacy of herbal medicines was confirmed using a copper electrode with the record 24 of tea in which the efficacy of herbal medicines was confirmed using an aluminum electrode. The generated voltage or current varies greatly depending on the conductivity and characteristics of the conductor used in the electrode and the characteristics of the extract that reacts to the conductor contained in the evaluation target. It can be seen that the range 22 of the efficacy of herbal medicines in tea when a copper electrode is used and the condition that the voltage converges within the range of ±10 mV for more than one hour after 24 hours from the start of measurement cannot be used as the evaluation criteria with an aluminum electrode. For this reason, when creating an evaluation criteria for the efficacy of herbal medicines, the same verification procedure must be performed for each type of conductor used in the electrode, and it must be specified whether the electrode device 2 using that conductor for the first and second electrodes 4 and 5 has the characteristics to determine whether the efficacy of herbal medicines is present in the evaluation target.

[0039] Based on the above verification, we will verify whether it is possible to determine the efficacy of herbal medicines in tea by using conductors other than copper for the first and second electrodes 4 and 5, using aluminum, which is easily available. First, water is measured with electrode device 2, which uses aluminum as a representative example of a state in which there is no efficacy of herbal medicines in the liquid, and its characteristics are understood. Figure 13 is a comparison graph showing the measurement and recording of water with different acidity levels using aluminum for the first and second electrodes 4 and 5. The dotted lines in the graph respectively represent tap water boiled in an enamel kettle with a pH of 9.3, purified water with a pH of 7.9, purified water with an acidity adjusted with citric acid with a pH of 4.9, and purified water with an acidity adjusted with citric acid with a pH of 2.7, while the solid lines represent the pH of 25 and 8.6 recorded using aluminum electrodes for water boiled in an iron kettle. All the readings except for record 25, which used the aluminum electrode for water boiled in an iron kettle, converged to within ±10mV after 30 hours of measurement, but record 25, which used the aluminum electrode for water boiled in an iron kettle (solid line), shows that the iron in the liquid 9 being judged reacts to the aluminum in the first and second electrodes 4 and 5, causing the voltage to fluctuate more significantly and for a longer period of time than the other measurement records. This shows that when aluminum is used for the first and second electrodes 4 and 5, the presence of iron in the liquid 9 being judged can be determined.

[0040] Next, we will compare the measurement records of tea with confirmed herbal efficacy measured with aluminum electrodes, tea picked in the same field as the tea with confirmed herbal efficacy, and herbal medicine made mainly from Ganoderma lucidum and Kawaratake mushrooms. The dotted lines in Figure 14 are the measurement records of tea with confirmed herbal efficacy and tea picked in the same field as the tea with confirmed herbal efficacy, which are produced in different years, and the solid lines are the measurement records of herbal medicine made mainly from Ganoderma lucidum and Kawaratake mushrooms, but no particularly similar characteristics can be seen. From this, it is clear that it is impossible to determine whether or not the herbal efficacy is present from the measurement records of the electrode device 2 using aluminum. However, after the measurement is completed, the first and second electrode terminals 6 and 7 are shorted and left to stand for 48 hours, and then the electrodes are observed, and as shown in the photograph in Figure 15, reddish-brown precipitates 27 are deposited on the surfaces of the first and second electrodes 4 and 5 of the electrode device 2 using aluminum used to measure tea with herbal efficacy. This characteristic of the aluminum electrode surface has not been observed in any teas for which no herbal medicine efficacy has been confirmed.

[0041] Experiments on the method for determining the efficacy of herbal medicines using the electrode device 2 were also conducted with the electrode device 2 using a copper electrode. As shown in Figure 16, in the case of the electrode device 2 using copper, no particular precipitate was found in the tea in which the efficacy of herbal medicines was confirmed even 14 days after the end of measurement, but in the case of commercially available tea in which the efficacy of herbal medicines was not confirmed, mold appeared between the liquid 9 to be determined and the air bubbles that appeared after the measurement began within 14 days after the end of measurement.

[0042] From the results of comparing and observing the measurement records, there are two methods for judging the efficacy of herbal medicines using the liquid measuring device 1 of the present invention. One is a method of measuring the voltage or current generated from the liquid 9 to be judged using the liquid measuring device 1, comparing the measurement record with a standard for each type of object to be judged, and judging the efficacy of the herbal medicine. The other is a method of judging the efficacy of the herbal medicine by storing the liquid 9 to be judged in the electrode device 2 and leaving it to stand, observing the internal state, and comparing it with the standard for each type of object to be judged. To implement these two methods for judging the efficacy of herbal medicines, a criterion for judging the efficacy of herbal medicines and a procedure for judging the efficacy of herbal medicines are required for each type of object to be judged, and if they do not exist for the object to be judged, it is necessary to create a procedure for judging the efficacy of herbal medicines and a criterion for judging the efficacy of herbal medicines by experiment. In addition, when creating a procedure for judging the efficacy of herbal medicines and a criterion for judging the efficacy of herbal medicines for a type of object to be judged for which a procedure for judging the efficacy of herbal medicines and a criterion for judging the efficacy of herbal medicines do not exist, it is assumed that the efficacy of the herbal medicines is clearly generated when the object to be judged is ingested.

[0043] The procedure for evaluating efficacy of herbal medicine includes a preparation procedure including a method for extracting the substance to be evaluated into the liquid 9 to be evaluated and an extraction time and a static fermentation time of the liquid 9 to be evaluated after the substance to be evaluated is extracted, a measurement procedure including a measurement method, measurement time, and measurement record interval when measuring the liquid 9 to be evaluated prepared in the preparation procedure with a liquid measurement device 1, an observation procedure including a method for leaving the electrode device 2 containing the liquid 9 to be evaluated after measurement or the electrode device 2 containing the liquid 9 to be evaluated prepared in the preparation procedure and a static leaving time, and a judgment procedure for comparing and verifying the measurement record or observation result with the efficacy evaluation criteria of the herbal medicine, and by combining these procedures, it becomes possible to estimate the degree of efficacy of the herbal medicine produced at the place where the substance to be evaluated is produced from the detection rate. The procedure for evaluating efficacy of herbal medicine also includes designation of the shape of the electrode device 2 according to the substance to be evaluated and the conductor to be used for the first and second electrodes 4 and 5, designation of the solvent to which the substance to be evaluated is extracted when preparing the liquid 9 to be evaluated, and designation of the container for preparing the liquid 9 to be evaluated.

[0044] As described above, the procedure for determining the efficacy of herbal medicines requires the following steps after the efficacy of the herbal medicine has been confirmed in the object to be determined: selecting the type of conductor to be used in the first and second electrodes 4 / 5; considering the method for producing the liquid 9 to be determined, the measurement method using the liquid measuring device 1, and the observation method for the electrode device 2; measuring records of the object to be determined that has the efficacy of a herbal medicine, multiple records of objects to be determined that are produced in the same place and by the same manufacturing method, and multiple records of the same type of object to be determined that has no confirmed efficacy of a herbal medicine, for each type of conductor used in the first and second electrodes 4 / 5; determining the determination conditions based on the threshold and variation of the generated voltage or current for each type of conductor used for measurement, referring to the records of objects to be determined that have the efficacy of different types of herbal medicines and the determination criteria; and determining the determination conditions based on the presence or absence of precipitates and precipitates of mold, etc. on the surfaces of the first and second electrodes 4 / 5 and inside the electrode device 2 by observing the electrode device 2 containing the liquid 9 to be determined.

[0045] In the preparation of the procedure for determining the efficacy of herbal medicines and the criteria for determining the efficacy of herbal medicines, when the subject to be determined is extracted to form the liquid to be determined 9, the extract reacts with the solvent to which it is extracted over a period of time according to the characteristics of the subject to be determined, thereby charging the liquid to be determined 9. If the subject to be determined is of a type for which a procedure for determining the efficacy of herbal medicines and criteria for determining the efficacy of herbal medicines exist, it is sufficient to perform measurements and observations according to the procedure for determining the efficacy of herbal medicines and criteria for determining the efficacy of herbal medicines to determine whether or not the herbal medicine is effective. However, when preparing a procedure for determining the efficacy of herbal medicines and criteria for determining the efficacy of herbal medicines for a subject to be determined for which a procedure for determining the efficacy of herbal medicines and criteria for determining the efficacy of herbal medicines do not exist, it is important to determine the time for which the liquid to be determined 9 is left to stand before measurement and whether or not there is a discharge at the beginning of the measurement during measurement. The fact that a large voltage or current is generated simply after the start of measurement does not clearly indicate the activity of the extract and prove the efficacy of the herbal medicine of the subject to be determined. For example, regarding record 20, which was taken using a copper electrode for tea in which the efficacy of herbal medicine was confirmed, as shown in Figure 7, which is easy to understand, the electrical insulation resting time for liquid 9 to be evaluated in the preparation procedure of liquid 9 to be evaluated is 24 hours, and the initial discharge of electrons charged during the preparation procedure is from 9 hours to 30 hours after the start of measurement, and the portion of voltage generated within ±10 mV from 30 hours to 32 hours and exceeding ±10 mV after 32 hours is the subject of activity evaluation for the extract, and is the portion that meets the criteria for evaluation of herbal medicine efficacy.

[0046] Even if the procedure for judging the efficacy of herbal medicines and the criteria for judging the efficacy of herbal medicines already exist for the object to be judged, the procedure for judging the efficacy of herbal medicines and the criteria for judging the efficacy of herbal medicines, which summarize the electrode shape and procedure, should be added or updated every time an effective method for improving the judgment accuracy or shortening the judgment time is discovered, and one procedure for judging the efficacy of herbal medicines and the criteria for judging the efficacy of herbal medicines do not necessarily correspond to one type of object to be judged. The procedure for judging the efficacy of herbal medicines in tea and the criteria for judging the efficacy of herbal medicines in tea described in this embodiment are one of the procedures for judging the efficacy of herbal medicines in tea and the criteria for judging the efficacy of herbal medicines, and are an example of the most easily implementable judgment method derived through experiments.

[0047] The procedure for determining efficacy of herbal medicines in tea by measurement and recording using the liquid measuring device 1 is as follows: the tea to be evaluated is boiled in water for 10 minutes in an electrically insulating container to extract the liquid 9 to be evaluated, and the liquid is left in an electrically insulating state for 24 hours to fully ferment the extract. The liquid 9 to be evaluated is then placed in an electrode device 2 using copper for the first and second electrodes 4 and 5, and measured and recorded by the liquid measuring device 1 at 1 second intervals for 48 hours. After the measurement is completed, the measurement and record measured by the liquid measuring device 1 is compared with the efficacy criteria for herbal medicines in tea to determine whether the criteria for efficacy of herbal medicines are met. This procedure makes it possible to determine efficacy of herbal medicines in tea.

[0048] The procedure for determining efficacy of herbal medicines in tea by static observation of the electrode device 2 is as follows: after the procedure for determining efficacy of herbal medicines in tea by measurement and recording using the liquid measuring device 1 based on the observation results of Figs. 15 and 16 is completed, the electrode device 2 in a state in which the liquid 9 to be determined is contained therein, or the liquid 9 to be determined is newly prepared by boiling and extracting the tea to be determined in water in an electrically insulating container for 10 minutes, electrically insulating it for 24 hours, and sufficiently cooling and fermenting the extract, and the liquid 9 to be determined is contained in the electrode device 2 using copper for the first and second electrodes 4 and 5, and the first and second electrode terminals are connected to the electrode device 2. 6 and 7 are electrically shorted, and the liquid is allowed to stand for 14 days, and then observed. If the criteria for efficacy of herbal medicines are met by comparing with the efficacy criteria for herbal medicines in tea, the tea to be judged is extracted by boiling in water for 10 minutes in an electrically insulating container, and the extract is sufficiently cooled and fermented under an electrically insulated state for 24 hours to create a liquid to be judged 9, which is then placed in electrode device 2 using aluminum for first and second electrodes 4 and 5, and the first and second electrode terminals 6 and 7 are electrically shorted, and the liquid is allowed to stand for 96 hours, and then observed and compared with the efficacy criteria for herbal medicines in tea. This procedure shows that the efficacy of herbal medicines in tea can be judged.

[0049] From a comparison of the measurement records in Figures 7 to 11, it can be seen that the standard for judging the efficacy of herbal medicines in tea based on the measurement records using liquid measuring device 1 is that the voltage converges to within ±10 mV for about an hour 24 hours after the start of measurement, or remains within ±10 mV from before 24 hours after the start of measurement to after 24 hours, and then the voltage exceeds ±10 mV, thereby determining that the tea being evaluated has the efficacy of herbal medicines.

[0050] From the observation results in Figures 15 and 16, it can be seen that the criteria for judging the efficacy of herbal medicines in tea by static observation of electrode device 2 are that when the liquid 9 to be judged is placed in electrode device 2 using copper for the first and second electrodes 4 and 5, no mold grows between the liquid 9 to be judged and the generated air bubbles, and when the liquid 9 to be judged is placed in electrode device 2 using aluminum for the first and second electrodes 4 and 5, the occurrence of reddish-brown precipitates on the surfaces of the first and second electrodes 4 and 5 can be confirmed, thereby determining that the tea to be judged has the efficacy of herbal medicines.

[0051] From the above verification, as shown in Figure 8, of the measurement records measured using the procedure for determining the efficacy of tea herbs based on measurement records using the liquid measuring device 1, 4 out of 23 measurement records were for tea harvested in the same field as the tea for which the efficacy of the herbs was confirmed to meet the efficacy criteria for tea herbs. Therefore, if 10 randomly selected teas are measured, it can be determined that at least one of them satisfies the efficacy criteria for tea herbs based on measurement records using the liquid measuring device 1, if the tea has the efficacy of herbs. From this, the method of judging the efficacy of herbal medicines in tea is to repeat the procedure of judging the efficacy of herbal medicines in tea by the measurement record using the liquid measuring device 1 10 times or more in the same field and with tea produced by the same production method, and judge whether the generated voltage meets the efficacy judgment criteria of herbal medicines in tea by the measurement record using the liquid measuring device 1, and if none of the measurement records meets the efficacy judgment criteria of herbal medicines in tea by the measurement record using the liquid measuring device 1, the presence or absence of efficacy of herbal medicines is judged by observing the electrode device 2 using the procedure of judging the efficacy of herbal medicines in tea by static observation of the electrode device 2, and the detection rate of tea with herbal medicine efficacy in the same field and with the same production method can be calculated. The procedure of calculating the detection rate of tea with herbal medicine efficacy is shown in the flowcharts of Figures 17 and 18. EXAMPLES

[0052] The verification experiments conducted during the development of this invention and their results are shown in the figures, and the process of inventing the liquid measuring device 1 and the method for determining the efficacy of herbal medicines is explained below.

[0053] When the inventor confirmed that the tumor contracted in the tea produced by the inventor, he first examined the acidity and sugar content to see what was different from other teas, but found no particular difference from commercially available teas.He then considered a method to electrically measure tea, devised a method to measure the fluctuations in voltage and current generated by tea, and carried out a verification experiment according to the following procedure.

[0054] First, the shape of the electrode device 2 to be used for the efficacy evaluation of herbal medicines and the experimental procedure for the efficacy evaluation method of herbal medicines will be described in this paragraph. paragraph 61 The components used in the electrode device 2, such as the container 10 and the first and second electrodes 4 and 5 for voltage or current detection, were a 50-milliliter glass Erlenmeyer flask that fits comfortably in the container 10, and cork was used as the stopper 8 for containing the liquid 9 to be evaluated without bubbles in the container 10, which is easy to process and through which the first and second electrode terminals 6 and 7 can be inserted. The first and second electrodes 4 and 5 were made of 0.3-mm-thick pure copper and aluminum plates, cut into two pieces measuring 100 mm in length and 10 mm in width. The contact areas of the first and second electrodes 4 and 5 with the liquid 9 to be evaluated were 60 mm in length and 10 mm in width. The first and second electrodes 4 and 5 were arranged so that their largest surfaces faced each other and were parallel to each other, with a gap of 1 mm. To secure the first and second electrodes 4 and 5 to the plug 8 and to maintain the electrode spacing, commercially available hot glue made of insulating material and resistant to acid is used to secure the electrode spacing fixing position 26 shown in Figure 6, and the first and second electrode terminals 6 and 7 are cut off leaving a length sufficient to be clamped by an alligator clip for connection to the measurement device 11. The dimensions of the measurement electrodes actually used are shown in Figure 6.

[0055] Each component of the electrode device 2 is disinfected by boiling and thoroughly dried in advance, and then assembled. The resistance between the first and second electrode terminals 6 and 7 is measured to confirm that the first and second electrodes 4 and 5 are electrically insulated.

[0056] Boil 1 liter of water in an enamel kettle or similar container that can electrically insulate the contents.

[0057] Five grams of the tea to be tested is placed in a non-woven fabric bag or similar and added to boiling water, then left to boil for 10 minutes.

[0058] After boiling for 10 minutes, cover both the water inlet and the pouring spout and leave to stand for 24 hours. Cool and ferment the liquid 9 to be judged, which contains the extract. Remove the nonwoven fabric pack containing the food when the liquid 9 to be judged has reached room temperature.

[0059] Before measurement, the measuring device 11 checks for current leakage from the measurement terminals using another ammeter or the like. Since the measuring device 11 measures the voltage or current generated from the liquid 9 to be evaluated, a voltmeter or ammeter with current leakage from the measurement terminals must not be used for measurement.

[0060] The liquid 9 to be evaluated is poured into the container 10 until it is full, the electrodes are inserted, and the measuring device 11 is connected to the first and second electrode terminals 6 and 7, and the voltage or current is measured and recorded at 1 second intervals for 48 hours. When inserting the electrodes into the container 10 filled with the liquid 9 to be evaluated, it is confirmed that the surface between the first electrode 4 and the second electrode 5 and the outer surface are completely in contact with the liquid 9 to be evaluated. If there are air bubbles, remove them before measurement.

[0061] After the measurement is completed, the electrode device 2 is separated from the liquid measurement device 1, the first and second electrode terminals 6 and 7 are shorted, and the electrode device 2 is left to stand and observed. This completes the procedure for the measurement and observation experiment.

[0062] The shape of the first and second electrodes 4 and 5 of the electrode device 2 used in the liquid measuring device 1 was verified as follows. Copper was used as the electrode material, and the shapes of the first and second electrodes 4 and 5 were tried as plate-like, cylindrical, different shapes for the first electrode 4 and the second electrode 5, sandwiching an electrode for induction between the first electrode 4 and the second electrode 5, and increasing the distance between the first and second electrodes 4 and 5. However, when the first and second electrodes 4 and 5 were cylindrical in shape, the voltage generation caused the detection position 28 of the efficacy of the herbal medicine to occur beyond the assumed measurement time of 48 hours, and it was unclear when a large fluctuation in voltage indicating the efficacy of the herbal medicine would occur. In addition, when the sizes of the first electrode 4 and the second electrode 5 were different, the voltage seemed to be drawn to the positive or negative side, and it was unclear how many volts should be the center. The results were difficult to grasp the characteristics. Therefore, in order to maximize the sensitivity of the nerves, which was the original starting point of the idea of ​​"if herbal medicines literally represent a living state, electrodes should be modeled as nerves to capture biological reactions," the area of ​​the opposing surfaces of the first and second electrodes 4 and 5 of the same shape and size was made as large as possible, and the electrode thickness and electrode spacing were made as thin and narrow as possible so that when the liquid 9 to be judged reacts to the first and second electrodes 4 and 5, the electric field lines passing through the opposing surfaces of the first and second electrodes 4 and 5 are secured widely and widely, and a clear difference in generated voltage was obtained as shown in the measurement record in Figure 7. For reference, Figure 19 shows a measurement record using a cylindrical copper electrode for tea, for which the efficacy of herbal medicines has been confirmed, and Figure 20 shows an example of a measurement record using an irregularly shaped copper electrode for tea, for which the efficacy of herbal medicines has been confirmed, with the first and second electrodes 4 and 5 of different sizes.

[0063] The procedure for preparing the liquid 9 to be judged in the procedure for judging the efficacy of herbal medicines in tea was carried out by measuring the liquid 9 to be judged, which was prepared by three different procedures, and the procedure that produced a clear difference was verified. Figure 21 is a comparison graph of the measurement records using a copper electrode for tea that was brewed normally, Figure 22 is a comparison graph of the measurement records using a copper electrode for tea that was boiled for 10 minutes, and Figures 7 to 9 are comparison graphs of the measurement records using a copper electrode for tea that was boiled for 10 minutes and then electrically insulated and left to ferment for 24 hours. In both graphs, the solid lines are teas for which the efficacy of herbal medicines has been confirmed, and the dotted lines are records for commercially available teas for which the efficacy of herbal medicines has not been confirmed. It can be seen from the graphs in Figures 21 and 22 that it is not possible to draw a clear threshold line as a standard, but it can be seen from Figures 7 and 9 that a clear threshold can be set, such as the efficacy judgment range 22 for herbal medicines in tea when a copper electrode is used. From this, when judging whether or not tea has any herbal efficacy, it can be judged that the procedure for preparing the liquid 9 to be judged is to boil the tea for 10 minutes in an electrically insulated state and then ferment it in an electrically insulated state for 24 hours, which is appropriate for judging whether or not tea has any herbal efficacy.

[0064] Figures 8 and 9 show graphs comparing the measurement records when verifying the efficacy evaluation criteria for herbal tea based on the measurement records using the liquid measurement device 1, which is the main method for evaluating the efficacy of herbal tea, and Figure 10 shows a graph of water measured and recorded using a copper electrode as an example of a state in which there are no herbal ingredients in the liquid. Figure 8 shows the records of tea harvested on each day in 2019 harvested in the same field as the tea for which the efficacy of herbal tea was confirmed, and Figure 9 shows the records of commercially available tea for which the efficacy of herbal tea was not confirmed. When copper is used for the first and second electrodes 4 and 5, if there are no herbal ingredients in the liquid 9 to be evaluated, the voltage falls within ±10 mV as shown in Figure 10. Next, looking at the voltage generation trend of commercially available tea for which the efficacy of herbal tea was not confirmed, a voltage of ±10 mV or more is generated for the first 24 hours from the start of measurement as shown in Figure 9, but after 24 hours from the start of measurement, the generated voltage falls within ±10 mV. As can be seen from Figures 9 and 10, when tea that does not have the efficacy of herbal medicine is boiled and extracted in an electrically insulated state, and then left to stand for 24 hours to allow the extract to ferment sufficiently, it discharges about 24 hours after the start of measurement, after which it loses activity and no longer generates a voltage of more than ±10mV. In contrast, Figure 8 shows that there are four records in which the voltage converges to within ±10mV for more than an hour 24 hours after the start of measurement, and then a voltage is generated that exceeds ±10mV after that. From this, it can be seen that one of the criteria for the measurement records that are determined to have the efficacy of herbal medicine among the measurement records that satisfy the range 22 for determining the efficacy of herbal medicine for tea when a copper electrode is used is whether the voltage converges to within ±10mV for more than an hour 24 hours after the start of measurement, and then a voltage is generated that exceeds ±10mV.

[0065] Figure 11 is a graph comparing the measurement records of two different objects with herbal medicine efficacy in order to investigate the voltage generation tendency of the object with herbal medicine efficacy. Compared to record 20 using the copper electrode of tea, which was confirmed to have herbal medicine efficacy, record 23 using the copper electrode of Chinese medicine made mainly from Ganoderma lucidum and Kawaratake mushroom, which was confirmed to have herbal medicine efficacy, the generated voltage converges within ±10mV for 24 hours after the start of measurement, and the voltage gradually increases after 24 hours, and after 33 hours, the voltage generated exceeds 100mV. As can be seen from this, it can be seen that one of the criteria for judging the efficacy of herbal medicine is whether the liquid 9 to be judged has a strong electron binding force before 24 hours after the start of measurement, suppressing the generated voltage, and after 24 hours, it reacts greatly to the copper electrode and generates a voltage exceeding ±10mV.

[0066] FIG. 12 is a comparison graph of measurements and records of tea that has been confirmed to have medicinal herbal efficacy, using electrode device 2 that uses copper for the first and second electrodes 4 and 5, and electrode device 2 that uses aluminum for the first and second electrodes 4 and 5. There is a difference in the voltage generation tendency between record 20 of tea that has been confirmed to have medicinal herbal efficacy, using the copper electrodes, and record 24 of tea that has been confirmed to have medicinal herbal efficacy, using the aluminum electrodes, and it can be seen that the range 22 of tea that can be used to determine the medicinal herbal efficacy when copper electrodes are used cannot be used with electrode device 2 that uses aluminum.

[0067] Figure 13 is a graph verifying the absence of herbal ingredients using electrode device 2, which uses aluminum for the first and second electrodes 4 and 5. The dotted lines, where no voltage exceeding ±10mV was generated after 30 hours, are tap water boiled in an enamel kettle at 9.3 pH, purified water at 7.9 pH, purified water with its acidity adjusted with citric acid at 4.9 pH, and purified water with its acidity adjusted with citric acid at 2.7 pH, while the solid lines, where voltages exceeding ±10mV were generated even after 24 hours, are records 25 and 8.6 pH, where an aluminum electrode was used for water boiled in an iron kettle. Record 25, where an aluminum electrode was used for water boiled in an iron kettle, continues to generate voltage due to the reaction between the iron dissolved in the water and the aluminum electrode surface, and the redox reaction continues even after 24 hours. As can be seen from the graph in Figure 10, where copper is used for the first and second electrodes 4 and 5 of the electrode device 2, the voltage generated 24 hours after the start of measurement is not due to differences in the acidity of the liquid 9 being evaluated, but rather the continuity of the redox reaction between the extract from the substance to be evaluated in the liquid 9 being evaluated and the first and second electrodes 4 and 5, in other words, the strength of activity. The problem here is that, depending on the type of conductor used for the electrodes, there are combinations in which a large voltage is generated for a long time by the extract of the substance to be evaluated that has dissolved in the liquid 9 being evaluated, even if the substance to be evaluated does not have the efficacy of a herbal medicine.

[0068] Figure 14 shows the records of measurements taken with electrode device 2, which uses aluminum for the first and second electrodes 4 and 5, on an object to be determined to have the efficacy of a herbal medicine. The solid line shows the measurement record of a traditional Chinese medicine made primarily from Ganoderma lucidum and Kawaratake mushrooms, which have been confirmed to have the efficacy of a herbal medicine, and the dotted line shows the measurement record of tea, which has the efficacy of a herbal medicine, but no similar characteristics can be found in either. This shows that there are no commonalities that would allow one to identify the efficacy of a herbal medicine from the records of objects to be determined to have the efficacy of a herbal medicine, which were measured with electrode device 2, which uses aluminum for the first and second electrodes 4 and 5.

[0069] Figures 23, 24, and 25 are records of tea measured with aluminum electrodes. Figure 23 shows two types of measurement records of new tea with no confirmed efficacy of commercially available herbal medicines, Figure 24 shows three types of measurement records: one for tea picked in the same field as tea with confirmed efficacy of herbal medicines and two for bancha with no confirmed efficacy of commercially available herbal medicines, and Figure 25 shows three types of measurement records of bottled green tea with no confirmed efficacy of commercially available herbal medicines and black tea with no confirmed efficacy of commercially available herbal medicines. Each figure has a common characteristic29 in the amplitude of voltage by time, and it can be inferred that Figure 23 is the first batch of tea picked in the first half of May, Figure 24 is the first batch of tea picked in the second half of May, and the black tea in Figure 25 is the second batch of tea picked in the month with the longest period from sunrise to sunset. The picking time of the commercially available bottled green tea is unknown, but judging from the characteristics of the voltage waveform, it is likely that the second batch of tea picked in the month with the longest period from sunrise to sunset is used. These figures show that the approximate picking time of tea can be determined from the tea records measured with an aluminum electrode.

[0070] Figures 15 and 16 show the observation of the electrode device 2 after the measurement was completed. The presence or absence of the efficacy of the herbal medicine can also be determined from the appearance of the surfaces of the first and second electrodes 4 and 5 and the inside of the electrode device 2. Figure 15 shows the surface appearance of the first and second electrodes 4 and 5 made of aluminum 48 hours after the measurement was completed. In the case of tea for which the efficacy of the herbal medicine was confirmed, a reddish-brown precipitate 27 as shown in Figure 15 is precipitated. This characteristic does not occur in commercially available tea for which the efficacy of the herbal medicine was not confirmed. In addition, Figure 16 shows the observation of the tea for which the efficacy of the herbal medicine was confirmed and the commercially available tea for which the efficacy of the herbal medicine was not confirmed after measurement with the electrode device 2 made of copper. The commercially available tea for which the efficacy of the herbal medicine was not confirmed had mold growth between the liquid 9 to be evaluated and the generated air bubbles, whereas the tea for which the efficacy of the herbal medicine was confirmed had no mold growth.

[0071] Figure 26 shows an exceptional case among the voltage measurement records using copper electrodes of commercially available tea that does not have any herbal efficacy. In a probability of less than 1 in 100 cases, the voltage does not converge to within ±10mV and continues to generate a nearly constant voltage before 24 hours have passed since the start of measurement. This phenomenon mainly occurs when mold that has grown in the liquid 9 to be judged between the first electrode 4 and the second electrode 5 causes an electrical short circuit. In this case, since the voltage does not converge to within ±10mV for more than 1 hour after 24 hours from the start of measurement, which is the condition for herbal efficacy, it can be determined that the herbal efficacy is not present. In addition, in this case, as shown in Figure 27, if the estimated judgment criterion deviation of 30 minutes is shifted from the average voltage measurement value of about -21mV after 24 hours from the start of measurement, it can be seen that the voltage fluctuation value after 24 hours is within ±10mV. [Explanation of symbols]

[0072] 1 Liquid measuring device 2 electrode device 3. Measurement and recording equipment 4 1st electrode 5 Second electrode 6 1st electrode terminal 7 Second electrode terminal 8 Stopper 9 Liquid to be judged 10 containers 11. Measurement Equipment 12 Recording Devices 13 Signal cables, etc. 14 Thickness of the first and second electrodes 15 Distance between the first and second electrodes 16 Depth of the first and second electrodes in the liquid to be judged 17 Volume between the first and second electrodes 18 Volume outside the mutually opposing planes of the first and second electrodes 19 Area of ​​the mutually facing planes of the first and second electrodes 20 Recording of tea with confirmed efficacy of herbal medicine using copper electrodes 21 Recording of tea with copper electrodes where the efficacy of herbal medicines is not confirmed 22. Range of efficacy assessment of herbal tea using copper electrodes 23 Recording of herbal medicine using copper electrodes, with the main ingredients being Ganoderma lucidum and Kawaratake mushroom, whose efficacy has been confirmed 24 Recording of tea with confirmed herbal medicine efficacy using aluminum electrodes 25 Recording of water boiled in an iron kettle using an aluminum electrode 26 Electrode spacing fixed position 27 Reddish brown precipitate 28 Location of herbal medicine efficacy detection 29 Common characteristics of voltage amplitudes over time 30 Expected deviations in judgment criteria

Claims

1. This is a method for determining the efficacy of a herbal medicine from the electrical activity state of an object to be determined, in which the object to be determined is extracted to prepare a liquid to be determined (9), and the voltage or current generated from the liquid to be determined (9) is measured by a liquid measuring device (1). A method for determining the efficacy of a herbal medicine, comprising:

2. The method uses the liquid measuring device (1) to determine whether or not the herbal medicine in the subject of evaluation has efficacy, and the liquid (9) to be evaluated is prepared according to a procedure for evaluating the efficacy of herbal medicine created for each type of subject of evaluation, and is placed in an electrode device (2). Fluctuations in voltage or current generated from the electrode device (2) containing the liquid (9) to be evaluated are measured and recorded using a measurement and recording device (3) according to the procedure for evaluating the efficacy of herbal medicine created for each type of subject of evaluation. The effectiveness of the herbal medicine is determined by comparing the measurement record with the efficacy evaluation criteria for herbal medicine created for each type of subject of evaluation.

2. The method for determining efficacy of a herbal medicine according to claim 1.

3. The method uses the electrode device (2) to determine whether or not the herbal medicine in the subject of evaluation is effective, and involves leaving the electrode device (2) containing the liquid (9) to be evaluated after the liquid measuring device (1) has been used to determine whether or not the herbal medicine in the subject of evaluation is effective, according to a procedure for determining the efficacy of the herbal medicine created for each type of subject of evaluation, or leaving the electrode device (2) containing the liquid (9) to be evaluated, which has been created according to a procedure for determining the efficacy of the herbal medicine created for each type of subject of evaluation, to stand. After a standing time specified in the procedure for determining the efficacy of the herbal medicine created for each type of subject of evaluation has elapsed, the presence or absence of the efficacy of the herbal medicine is determined by comparing the precipitates other than the liquid (9) to be evaluated that are precipitated inside the electrode device (2) and on the surfaces of the first electrode (4) and the second electrode (5) with the efficacy criteria for the herbal medicine created for each type of subject of evaluation. The method for determining efficacy of a herbal medicine according to claim 2.

4. The procedure for determining efficacy of a herbal medicine according to claim 2 and / or claim 3, which is created for a subject for which efficacy of a herbal medicine has been confirmed and is applied to all subjects of the same type as the subject for which efficacy of a herbal medicine has been confirmed, includes a procedure for creating the liquid to be determined (9) including a shape of the electrode device (2) used in the liquid measuring device (1) and designation of conductors to be used for the first electrode (4) and the second electrode (5), a method and extraction time for extracting the subject for determination, and a static fermentation time for the liquid to be determined (9) from which the subject for determination has been extracted, and a method for measuring the efficacy of the liquid to be determined (9) using the liquid measuring device (1). a measurement procedure including a measurement method and a measurement time and a measurement record interval for specifying whether or not to perform a measurement; an observation procedure including a method and a time for leaving the electrode device (2) containing the liquid (9) to be evaluated after the measurement is completed or the electrode device (2) containing the newly prepared liquid (9) to be evaluated in an unused electrode device (2); and a judgment procedure for judging the presence or absence of efficacy of the herbal medicine of the evaluation object by comparing the efficacy judgment criteria for the herbal medicine prepared for each type of evaluation object with the records measured by the liquid measuring device (1), the state inside the electrode device (2), and the state of the surfaces of the first electrode (4) and the second electrode (5). The method for determining efficacy of a herbal medicine according to claim 2 or 3.

5. The efficacy judgment criterion for herbal medicine according to claim 2 and / or claim 3 is created for an object to be judged for which the efficacy of the herbal medicine has been confirmed and is applied to all objects of the same type as the object to be judged for which the efficacy of the herbal medicine has been confirmed, and includes: a comparison of a plurality of measurement records of objects to be judged that are produced in the same place of origin and produced by the same method, including the object to be judged for which the efficacy of the herbal medicine has been confirmed, and a comparison criterion for the presence or absence of efficacy of the herbal medicine based on a threshold value for voltage or current for each elapsed time derived from a difference other than the positive or negative voltage or current of the measurement records, and a comparison criterion for the presence or absence of efficacy of the herbal medicine based on the presence or absence of a precipitate other than the liquid to be judged (9) on the surfaces of the first electrode (4) and the second electrode (5) and inside the electrode device (2) after a specified time has elapsed. The method for determining efficacy of a herbal medicine according to claim 2 or 3.

6. The procedure for evaluating the efficacy of herbal medicines for tea is based on the procedure for evaluating the efficacy of herbal medicines as described in claim 4, and the liquid (9) to be evaluated is prepared by boiling and extracting the tea to be evaluated in water for 10 minutes in an electrically insulating container, followed by static fermentation for 24 hours, and the liquid is placed in the electrode device (2) using copper for the first electrode (4) and the second electrode (5), and the voltage is measured and recorded every second for 48 hours by the liquid measuring device (1). The procedure includes comparing the measurement record with the efficacy evaluation standard for herbal medicines for tea. A method for determining the efficacy of tea herbs.

7. This is a procedure for determining the efficacy of herbal medicines for tea based on the procedure for determining the efficacy of herbal medicines described in claim 4, in which the electrode device (2) containing the liquid (9) to be determined used for measurement in claim 6, or a liquid to be determined newly prepared by boiling and extracting the tea to be determined in water for 10 minutes in an electrically insulating container and then leaving it to ferment for 24 hours, is contained in the electrode device (2) in which copper is used for the first electrode (4) and the second electrode (5). The first electrode terminal (6) and the second electrode terminal (7) of the electrode device (2) are electrically shorted, and the result is left to stand for 14 days and compared with the efficacy criteria for herbal medicines for tea. If the condition for determining whether the tea has efficacy as a herbal medicine is satisfied, the liquid (9) to be determined is extracted by boiling in water for 10 minutes in an electrically insulating container, and then left to stand for 24 hours to ferment, and the liquid (9) to be determined is stored in the electrode device (2) using aluminum for the first electrode (4) and the second electrode (5). The first electrode terminal (6) and the second electrode terminal (7) of the electrode device (2) are electrically short-circuited, and the liquid is left to stand for 96 hours, and compared with the efficacy criteria for herbal medicine of tea. The method for determining efficacy of tea herbs according to claim 6.

8. The efficacy criteria for herbal medicines in tea are based on the efficacy criteria for herbal medicines as described in claim 5, and are used to determine the presence or absence of efficacy of herbal medicines in tea from records measured according to the procedure for determining efficacy of herbal medicines in tea as described in claim 6. The efficacy criteria for herbal medicines in tea are determined to have herbal medicine efficacy when the voltage converges once within ±10 mV for about one hour after 24 hours from the start of measurement and then exceeds ±10 mV, or when the voltage remains within ±10 mV from before 24 hours to after 24 hours from the start of measurement and then exceeds ±10 mV. The method for determining efficacy of tea herbs according to claim 6.

9. The efficacy criterion for tea herbal medicine based on the efficacy criterion for herbal medicine as described in claim 5, and the efficacy criterion for tea herbal medicine is for judging the presence or absence of efficacy of tea herbal medicine by observing the state of the electrode device (2) containing the liquid (9) to be judged, which is prepared according to the procedure for judging efficacy of tea herbal medicine as described in claim 7, and judges that the tea to be judged has efficacy of herbal medicine by confirming that there is no mold growth between the liquid (9) to be judged and the gas generated by the oxidation-reduction reaction inside the electrode device (2) using copper for the first electrode (4) and the second electrode (5), and that a reddish-brown precipitate is generated on the surface of the first electrode (4) and the second electrode (5) of the electrode device (2) using aluminum for the first electrode (4) and the second electrode (5). The method for determining efficacy of tea herbs according to claim 6.

10. The liquid measuring device (1) for determining the efficacy of herbal medicine is a device that measures the liquid (9) to be determined by utilizing the wave properties of electrons, and is equipped with the electrode device (2) that causes an oxidation-reduction reaction when the liquid (9) to be determined is contained in the electrode device (2), and the measurement and recording device (3) that measures and records the voltage or current generated from the electrode device (2) when the liquid (9) to be determined is contained therein. A liquid measuring device (1).

11. The electrode device (2) includes the first electrode (4) and the second electrode (5) having surfaces made of the same conductor that undergoes an oxidation-reduction reaction with the liquid (9) to be determined, the first electrode terminal (6) electrically connected to the first electrode (4), and the second electrode terminal (7) electrically connected to the second electrode (5). Liquid measuring device (1) according to claim 10.

12. The first electrode (4) and the second electrode (5) are plate-shaped and have the same shape, and are arranged with their largest flat surfaces facing each other and parallel to each other. Liquid measuring device (1) according to claim 10.

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