Body fluid extract containing micro RNA

JP2025098184APending Publication Date: 2025-07-01CRAIF INC
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Patent Information

Application Number
JP2025052355
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2019-09-09
Filing Date
2025-03-26
Publication Date
2025-07-01

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Abstract

To provide an analytic method for a body fluid extract containing micro RNAs.SOLUTION: The present invention provides a method for predicting the likelihood that a subject has lung cancer for the subject having or suspected of having lung cancer, the method comprising predicting the likelihood that the subject has lung cancer using the expression level of let-7a-5p in a urine extract obtained from the subject as an indicator.SELECTED DRAWING: None
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Claims

1. 1. A method for predicting the likelihood of a subject having lung cancer in a subject having or suspected of having lung cancer, comprising: A method comprising predicting the possibility that the subject has lung cancer using the expression level of let-7a-5p in a urinary extract obtained from the subject as an index.

2. In addition to let-7a-5p, (i) any microRNA listed in Table 3-1, Table 3-2, or Table 2; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Tables 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4 to 15 The method of claim 1, wherein when the expression level of any one or more microRNAs {in each table, the microRNA may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}, among one or more types of microRNAs selected from the group consisting of, is equal to or greater than a first threshold value set for each microRNA, it is indicated that the urine is likely derived from a lung cancer patient.

3. The method of claim 2, wherein when an expression level of one or more of the microRNAs in each table whose expression levels are increased in lung cancer patients is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be likely to be derived from a patient having lung cancer.

4. The method of claim 2 or 3, wherein the first threshold is equal to or lower than the third quartile value of the corresponding microRNA in healthy individuals.

5. In addition to let-7a-5p, miR-17-5p, miR-33a-5p, miR-95-3p, miR-9-5p, miR-155-5p, miR-496, miR-544a, mi R-556-5p, miR-577, miR-607, miR-19a-5p, miR-548c-5p, miR-548o-5p, miR-548am-5 p, miR-1278, miR-3117-3p, miR-3128, miR-3139, miR-3145-3p, miR-3201, miR-4282 , miR-548ad-3p, miR-548ag, miR-4471, miR-4678, miR-4699-5p, miR-4704-3p, miR-1 245b-5p, miR-5582-5p, miR-5582-3p, miR-5590-5p, miR-548aw, miR-5683, miR-580-5p, miR-1252-3p, miR-8058, and miR-548bb-5p. When the expression level of any one or more types of microRNAs {which may be one or more types, two or more types, three or more types, four or more types, five or more types, ten or more types, fifteen or more types, or twenty or more types of microRNAs} selected from the group consisting of microRNAs is equal to or greater than a first threshold value set for each microRNA, the urine is indicated to be possibly derived from a patient having lung cancer. The method according to any one of claims 2 to 4.

6. In addition to let-7a-5p, (i) any microRNA listed in Table 3-1, Table 3-2, or Table 2; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Tables 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4 to 15 The method according to claim 1, wherein, when the expression level of any one or more microRNAs {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs} whose expression levels are decreased in lung cancer patients among one or more microRNAs selected from the group consisting of: is equal to or lower than a second threshold value set for each microRNA, it is indicated that the urine may be derived from a patient having lung cancer.

7. A method for predicting the likelihood that a subject will not have lung cancer in a subject suspected of having or having lung cancer, comprising detecting let-7a-5p or In addition to let-7a-5p, among any of the microRNAs described in Table 2, Table 3-1, Table 3-2, and Tables 4-1 to 4-15, let-7c-5p, let-7d-5p, let-7f-5p, miR-18a-5p, miR-19a-3p, miR-20a-5p, miR-21-5p, miR-24-1-5p, miR-26a-5p, miR-26b-5p, miR-31-5p, miR-96-5p, miR-98-5p, miR-99a-5p, miR-100-5p, miR-101-3p, miR-106a-5p, miR-148a-3p, miR-7-5p, miR-181c-5p, miR-182-3p, miR-216a-5p, miR-217-5p, miR-219a-5p, miR-222-3p, miR-1-3p, miR-130a-3p, miR-137-3p, miR-142-5p, miR-144-3p, miR-152-3p, miR-153-3p, miR-9-3p, miR-126-5p, miR-126-3p, miR-127-3p, miR-136-5p, miR-150-5p, miR-186-5p, miR-190a-5p, miR-200a-3p, miR-302a-5p, miR-30e-5p, miR-362-5p, miR-302b-5p, miR-302b-3p, miR-302c-3p, miR-302d-3p, miR-367-3p, miR-376c-3p, miR-369-3p, miR-376a-3p, miR-377-3p, miR-384, miR-409-5p, miR-410-3p, miR-376b-3p, miR-146b-5p, miR-520f-3p, miR-519c-3p, miR-523-3p, miR-518c-3p, miR-524-3p, miR-518d-3p, miR-499a-5p, miR-505-3p, miR-507, miR-508-3p, miR-514a-3p, miR-455-5p, miR-545-3p, miR-553, miR-559, miR-561-3p, miR-567, miR-568, miR-569, miR-570-3p, miR-573, miR-582-5p, miR-548a-3p, miR-586, miR-548b-3p, miR-590-5p, miR-592, miR-597-5p, miR-599,miR-606, miR-548c-3p, miR-618, miR-620, miR-621, miR-33b-5p, miR-633 、miR-648, miR-6511-5p, miR-411-5p, miR-655-3p, miR-60-5 p, miR-542-3p, miR-758-3p, miR-454-3p, miR-802, miR-19b-1-5p, miR-19 b-2-5p,miR-28-3p,miR-100-3p,miR-105-3p,miR-10d-3p,miR-10a-3p,mi R-10b-3p,miR-34a-3p,miR-196a-3p,miR-218-1-3p,miR- 221-5p,miR-27b-5p,miR-195-3p,miR-26a-2-3p,miR-367-5p,miR-374a-3 p, miR-340-5p, miR-135b-3p, miR-488-3p, miR-497-3p, miR-455-3p, miR- 545-5p,miR-556-3p,miR-576-3p,miR-548a-5p 、miR-628-5p,miR-548d-5p,miR-40b-3p,miR-890,miR-89-3p,miR-875 -5p,miR-876-5p,miR-708-3p,miR-190b-5p,miR-873-5p,miR-301b-3p,mi R-208b-3p,miR-922,miR-934,miR-944,miR-1185-5p,miR-1283,miR-117 9, miR-183, miR-1206, miR-548e-3p, miR-548j-5p, miR-548k, miR-1295a, miR-1302, miR-1305, miR-1244, miR-1245a, miR-1256, miR-1258, miR-126 1, 1262 ... 1277-3p,miR-548i,miR-1282,miR-1197,miR-1537-3p,miR-205-3p,miR-1 973, miR-2054, miR-759, miR-2115-3p, miR-3115, miR-3118, miR-3121-3p,miR-3123,miR-3129-5p,miR-3134,miR-3135a,miR-544b,miR-3140-3p,m iR-548t-5p,miR-3143,miR-548u,miR-3146,miR-3152-3p,miR-3159,miR -3167, miR-3171, miR-548w, miR-3183, miR-3065-5p, miR-4302, miR-4309 、miR-4263, miR-4277, miR-4291, miR-3606-5p, miR-3609, miR-3 611, miR-3613-5p, miR-3616-5p, miR-3618, miR-23c, miR-3658, miR-366 、miR-3664-5p, miR-368, miR-3671, miR-3672, miR-3674, miR-3683, miR-3 684, miR-3689a-5p, miR-3689b-5p, miR-3689e, miR-3912-3p, m iR-3914, miR-3920, miR-3923, miR-3927-3p, miR-3938, miR-548y, miR-393 9, miR-548h-3p, miR-4422, miR-548ac, miR-442, miR-4426, mi R-4427, miR-548ae-3p, miR-4445-5p, miR-4452, miR-4457, miR-4464, miR- 548ai, 70-5p, 548aj-3p, 77a, 77a, 77a, 7iR, 748ak, 7iR -4490,0000!miR-4503,-4504,-iR-4509,-iR-4517,-iR-4528,-iR -548an,miR-3117-5p,miR-3121-5p,miR-3124-3p,miR-3136-3p,miR-314 0-5p, miR-364-3p, miR-3688-5p, miR-3942-3p, miR-4474-5p, miR-3976, m iR-3977, miR-4636, miR-462a-5p, miR-462a-3p, miR-4659b-5p, miR-46 63, miR-4662b, miR-4666a-5p, miR-4666a-3p, miR-4668-3p, miR-219b-3p,miR-4677-3p, miR-4679, miR-4680-5p, miR-4680-3p, miR-4 683, miR-4693-5p, miR-4693-3p, miR-4696, miR-4699-3p, miR-4703-5p, mi R-4705, miR-203b-3p, miR-471-5p, miR-4714-3p, miR-4720-3p, miR-473 5-5p,miR-4742-5p,miR-4744,miR-499b-5p,miR-4757-5p,m iR-4757-3p,miR-4760-5p,miR-4760-3p,miR-4760-3p,miR-47 72-5p,!miR-4772-3p,!miR-4774-3p,!miR-4777- 3p, miR-4778-3p, miR-4782-5p, miR-4782-3p, miR-1245b-3p, miR-4789-5 p, miR-4789-3p, miR-4790-3p, miR-4795-5p, miR-4798-5p, miR-4798-5p, m iR-4799-3p,miR-4520-2-3p,miR-5047,miR-548ah-3p,miR-548ao-5p,mi R-548ap-5p,miR-548ap-3p,miR-5186,miR-5191,miR-5197-3p,miR-548aq -5p,miR-548aq-3p,miR-548ar-5p,miR-548ar-3p,miR-5583-5p,miR-558 3-3p,miR-5586-5p,miR-548au-5p,miR-5590-3p,miR-5591-5p,miR-548av -5p, miR-5682, miR-5692c, miR-5687, miR-5688, miR-5691, miR-5692a, mi R-5697, miR-5700, miR-5692b, miR-40a-1-3p, miR-506-5p, miR -539-3p,miR-561-5p,miR-1271-3p,miR-548g-5p,miR-548x-5p,miR-548 aj-5p,miR-1277-5p,miR-513c-3p,miR-1178-5p,miR-36-3p,miR-6079,miR-6128, miR-548ay-5p, miR-548az-5p, miR-548az-3p, miR-6502 -3p, miR-6508-3p, miR-95-5p, miR-215-3p, miR-153-5p, miR-190a -3p, miR-412-5p, miR-520g-5p, miR-510-3p, miR-653-3p, miR-670-3p, miR-548e-5p, miR-548f-5p, miR-513b-3p, miR-1537-5p, miR- 6733-5p, miR-6811-5p, miR-6828-3p, miR-6838-3p, miR-6844, miR-6854-5p, miR-6864-3p, miR-6866-5p, miR-7153-5p, miR-7153-3p , miR-7154-5p, miR-7159-3p, miR-7160-3p, miR-7161-3p, miR-7705, miR-6516-3p, miR-8053, miR-8056, miR-8061, miR-8066, miR-80 67, miR-8076, miR-181b-2-3p, miR-548ad-5p, miR-548ae-5p, miR-548bb-3p, miR-520e-5p, miR-549a-5p, miR-147b-5p, miR-9900, mi R-548bc, miR-10393-5p, miR-10393-3p, miR-10397-3p, miR-10399-5p, miR-10525-3p, miR-12123, miR-12129, miR-12130, and miR-12 132 is less than a first threshold value for a microRNA that is more highly expressed in lung cancer patients than in non-lung cancer patients, or is greater than or equal to a second threshold value for a microRNA that is less highly expressed in lung cancer patients than in non-lung cancer patients, indicating that the urine is likely to be derived from a patient without lung cancer.

8. A method for predicting the possibility that a subject has early-stage lung cancer in a subject having or suspected of having lung cancer, the method comprising predicting the possibility that the subject has early-stage lung cancer using the expression level of let-7a-5p in a urinary extract of the subject as an index, or using the expression of a microRNA listed in any one of Tables 22-1 and Tables 23-1 to 23-14 in addition to let-7a-5p as an index {each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}.

9. A method for predicting the possibility that a subject having or suspected of having lung cancer has early stage I lung cancer, the method comprising predicting the possibility that the subject has early stage lung cancer using the expression level of let-7a-5p in a urinary extract of the subject as an index, or using the expression of a microRNA listed in any one of Tables 22-1 to 22-13 in addition to let-7a-5p (which may independently be 1 or more types, 2 or more types, 3 or more types, 4 or more types, 5 or more types, 10 or more types, 15 or more types, or 20 or more types of microRNA in each table) as an index.

10. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with the nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, (i) any microRNA listed in Table 3-1, Table 3-2, or Table 2; (ii) any microRNA listed in Table 4-1; (iii) any microRNA listed in Table 4-2; (iv) any microRNA listed in Table 4-3; (v) any microRNA listed in Table 4-4; (vi) any microRNA listed in Tables 4-5; (vii) any microRNA listed in Tables 4-6; (viii) any microRNA listed in Tables 4-7; (ix) any microRNA listed in Tables 4-8; (x) any microRNA listed in Tables 4-9; (xi) any microRNA listed in Tables 4-10; (xii) any microRNA listed in Tables 4-11; (xiii) any microRNA listed in Tables 4-12; (xiv) any microRNA listed in Tables 4-13; (xv) any microRNA listed in Tables 4-14; and (xvi) any microRNA listed in Tables 4 to 15 one or more microRNAs selected from the group consisting of {in each table, each may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; The urine is from a subject having or suspected of having lung cancer. method.

11. 11. The method of claim 10, Specific microRNAs include let-7a-5p, as well as Below (ii) to (xiii): (ii) any microRNA with a p-value of less than 0.005 listed in Table 4-1; (iii) any microRNA having a p-value of less than 0.005 as set forth in Table 4-2; (iv) any microRNA having a p-value of less than 0.005 as set forth in Table 4-3; (v) any microRNA having a p-value of less than 0.005 as set forth in Table 4-4; (vi) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-5; (vii) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-6; (viii) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-7; (ix) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-8; (x) any microRNA listed in Tables 4-9 having a p-value of less than 0.005; (xi) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-10; (xii) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-11; and (xiii) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-12; (xiv) any microRNA having a p-value of less than 0.005 listed in Tables 4-13; (xv) any microRNA having a p-value of less than 0.005 listed in Tables 4-14; and (xvi) any microRNA having a p-value of less than 0.005 as set forth in Tables 4-15 one or more microRNAs selected from the group consisting of {in each table, each may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; method.

12. The method for analyzing a urine sample according to claim 10 or 11, Specific microRNAs include let-7a-5p and (ii) A method in which the microRNA is any one of those listed in Table 4-1 {which may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}.

13. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with the nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, (a) a microRNA described in any one of Tables 22-1 and 23-1 to 23-13 {in each table, the microRNA may be one or more, two or more, three or more, four or more, five or more, ten or more, fifteen or more, or twenty or more microRNAs}; The urine is from a subject having or suspected of having lung cancer. method.

14. A method for analyzing a urine sample according to claim 13, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (b) a microRNA listed in any one of Tables 22-1 to 22-13 {each of the tables may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; method.

15. A method for analyzing a urine sample according to claim 13, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (a) a microRNA listed in any one of Tables 22-1 and 23-1 to 23-13 (which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table), wherein the microRNA has an accuracy of 70% or more.

16. A method for analyzing a urine sample according to claim 13, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (a) a microRNA listed in any one of Tables 22-1 and 23-1 to 23-13 (which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table), wherein the microRNA has an accuracy of 80% or more.

17. A method for analyzing a urine sample according to claim 13, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (a) a microRNA listed in any one of Tables 22-1 and 23-1 to 23-13 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 90% or more.

18. 15. A method for analyzing a urine sample according to claim 14, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (b) a microRNA listed in any one of Tables 22-1 to 22-13 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 70% or more.

19. 15. A method for analyzing a urine sample according to claim 14, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (b) a microRNA listed in any one of Tables 22-1 to 22-13 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 80% or more.

20. 15. A method for analyzing a urine sample according to claim 14, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (b) a microRNA listed in any one of Tables 22-1 to 22-13 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 90% or more.

21. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with the nanowires; Extracting the microRNA captured on the nanowire; and To confirm whether a specific microRNA is included in the extracted microRNA This includes: The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, (c) a microRNA listed in any one of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 (each of which may independently be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs); The method, wherein the urine is urine from a subject having or suspected of having lung cancer.

22. 22. The method of claim 21, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (c) a microRNA listed in any one of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 70% or more in the table.

23. 22. The method of claim 21, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (c) a microRNA listed in any one of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 80% or more in the table.

24. 22. The method of claim 21, comprising: Specific microRNAs include let-7a-5p and In addition to let-7a-5p, (c) a microRNA listed in any one of Tables 22-1 to 22-13 and Tables 23-1 to 23-14 {which may be independently 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs in each table}, wherein the microRNA has an accuracy of 90% or more in the table.

25. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having metal oxide nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or let-7a-5p,miR-134-5p,miR-346,miR-564,miR-574-3p,miR-575,mi R-632,miR-661,miR-663a,miR-658, miR-297,miR-139-3p,miR-149-3p,m iR-20b-3p,miR-431-3p,miR-550a-5 p,miR-885-5p,miR-936,miR-937-3p ,miR-943,miR-1228-5p,miR-1184,m iR-1204,miR-1538,miR-1909-5p,mi R-1910-5p,miR-1912-3p,miR-196b- 3p,miR-1972,miR-3153,miR-3162-5 p,miR-1193,miR-4260,miR-4253,mi R-4326,miR-4269,miR-4276,miR-36 22a-3p,miR-3646,miR-3652,miR-31 80,miR-550b-3p,miR-4428,miR-443 3a-3p,miR-4440,miR-4444,miR-444 7,miR-4449,miR-4455,miR-3155b,m iR-4483,miR-4498,miR-2392,miR-4 535,miR-4539,miR-3173-5p,miR-45 29-5p,miR-4638-5p,miR-4655-5p,m iR-4685-3p,miR-1343-3p,miR-4701 -3p,miR-4717-3p,miR-4725-5p,miR -4726-3p,miR-4732-5p,miR-4738-3 p,miR-4748,miR-4750-5p,miR-371b -5p,miR-4436b-5p,miR-4793-3p,mi R-5001-3p,miR-5002-3p,miR-5006- 5p,miR-5090,miR-5572,miR-5584-3 p,miR-5705,miR-1237-5p,miR-6072 ,miR-6131,miR-6503-3p,miR-6511b -5p,miR-1296-3p,miR-5189-3p,miR -6728-5p,miR-6729-5p,miR-6736-3 p,miR-6738-5p,miR-6738-3p,miR-6 740-3p,miR-6753-5p,miR-6754-3p,Selected from the group (ALL) consisting of miR-6756-5p, miR-6759-5p, miR-6765-5p, miR-6768-5p, miR-6772-3p, miR-6773-3p, miR-6787-3p, miR-6790-5p, miR-6792-5p, miR-6798-5p, miR-6804-3p, miR-6805-5p, miR-6809-3p, miR-6816-5p, miR-6820-5p, miR-6821-5p, miR-6821-3p, miR-6822-5p, miR-6830-3p, miR-6832-3p, miR-6833-5p, miR-6833-3p, miR-6834-5p, miR-6780b-3p, miR-6854-3p, miR-6862-5p, miR-6867-5p, miR-6868-3p, miR-6871-5p, miR-6875-3p, miR-6877-5p, miR-6878-3p, miR-6882-3p, miR-6883-5p, miR-6883-3p, miR-6893-3p, miR-6894-3p, miR-7109-3p, miR-7152-5p, miR-7160-5p, miR-7843-5p, miR-8059, miR-8077, miR-7977, miR-4485-5p, miR-8485, miR-9718, miR-10396a-5p, miR-10398-5p, miR-10396b-5p, and miR-11400, The urine is from a subject having or suspected of having lung cancer. method.

26. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having metal oxide nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, let-7e-5p, miR-23a-3p, miR-24-3p, miR-25-3p, miR-28-5p, miR-29a-3p, miR-30a-3p, miR-92a-3p, miR-29b-3p, miR-105-5p, miR-192-5p, miR-199a-5p, miR-129-5p, miR-30c-5p, miR-181a-5p, miR-181b-5p, miR-182-5p, miR-187-3p, miR-205-5p, miR-210-3p, miR-211-5p, miR-212-3p, miR-214-3p, miR-221-3p, miR-200b-3p, let-7i-5p, miR-15b-5p, miR-23b-3p, miR-27b-3p, miR-138-5p, miR-143-3p, miR-134-5p, miR-146a-5p, miR-154-5p, miR-184, miR-194-5p, miR-34b-5p, miR-34c-5p, miR-299-3p, miR-99b-5p, miR-296-5p, miR-361-5p, miR-370-3p, miR-371a-3p, miR-373-5p, miR-378a-3p, miR-381-3p, miR-382-5p, miR-340-3p, miR-330-3p, miR-328-3p, miR-342-3p, miR-323a-3p, miR-338-3p, miR-325, miR-346, miR-196b-5p, miR-422a, miR-449a, miR-200a-5p, miR-433-3p, miR-323b-5p, miR-484, miR-485-5p, miR-485-3p, miR-486-5p, miR-487a-3p, miR-488-5p, miR-489-3p, miR-491-5p, miR-511-5p, miR-202-3p, miR-492, miR-432-5p, miR-494-3p, miR-497-5p, miR-512-5p, miR-512-3p, miR-498-5p, miR-515-5p, miR-515-3p, miR-519e-3p, miR-520a-3p, miR-526b-5p, miR-525-5p, miR-525-3p, miR-517a-3p, miR-517b-3p, miR-519d-3p, miR-521,miR-520d-3p,miR-520g-3p,miR-516b-3p,miR-516a-3p,miR-517c-3p,mi R-520h,miR-519a-3p,miR-500a-3p,miR-501-5p,miR-506- 3p,miR-509-3p,miR-510-5p,miR-299-5p,miR-18a-3p,miR-493-3p,miR- 487b-3p,miR-551a,miR-554,miR-92b-3p,miR-557,miR-558,miR-564,mi R-551b-3p,miR-572,miR-574-3p,miR-575,miR-579-3p,miR-584-5p,miR -589-3p,miR-550a-3p,miR-591,miR-593-5p,miR-595,miR-601,miR-602 ,miR-603,miR-604,miR-608,miR-609,miR-610,miR-612,miR-614,miR-6 15-3p,miR-616-5p,miR-617,miR-622,miR-623,miR-628-3p,miR-629-3p ,miR-631,miR-632,miR-634,miR-635,miR-636,miR-637,miR-638,miR-6 39,miR-642a-5p,miR-64a,miR-645,miR-649,miR-650,miR-61,miR-66 3a,miR-449b-5p,miR-654-5p,miR-657,miR-658,miR-542-5p,miR-363-� p,miR-671-5p,miR-668-3p,miR-454-5p,miR-769-3p,miR-7 66-3p,miR-765,miR-70-5p,miR-675-5p,miR-297,let-7d-3p,miR-15a- 3p,miR-16-1-3p,miR-21-3p,miR-23a-5p,miR-25-5p,miR -26b-3p,miR-92a-2-5p,miR-16-2-3p,miR-139-3p,miR-7-1-3p,miR-181 a-2-3p,miR-181c-3p,miR-183-3p,miR-187-5p,miR-214-5p,miR-222-5p,miR-200b-5p,miR-15b-3p,miR-30b-3p,miR-124-5p,miR-125b-1-3p,miR -135a-3p,miR-138-2-3p,miR-141-5p,miR-125a-3p,miR-125b-2-3p,miR- 138-1-3p,miR-149-3p,miR-185-3p,miR-186-3p,miR-193a-5p,miR-200c -5p,miR-194-3p,miR-106b-3p,miR-29c-5p,miR-219a-2-3p,miR-34b-3p, miR-34c-3p,miR-99b-3p,miR-296-3p,miR-130b-5p,miR-371a-5p,miR-3 77-5p,miR-330-5p,miR-342-5p,miR-323a-5p,miR-151a-5p,miR-338-5p, miR-339-3p,miR-335-3p,miR-424-3p,miR-18b-3p,miR-20b -3p,miR-431-3p,miR-483-5p,miR-486-3p,miR-146b-3p,miR-193b-5p,mi R-500a-5p,miR-505-5p,miR-508-5p,miR-532-3p,miR-92b-5p,miR-551b -5p,miR-574-5p,miR-589-5p,miR-550a-5p,miR-593-3p,miR-615-5p,miR -625-3p,miR-629-5p,miR-411-3p,miR-654-3p,miR-671-3p,miR-891a-� p,miR-300,miR-892a,miR-874-3p,miR-888-3p,miR-892b,miR-541-5p,mi R-541-3p,miR-875-3p,miR-708-5p,miR-147b-3p,miR-744- 3p,miR-885-5p,miR-885-3p,miR-877-3p,miR-887-3p,miR-6 65,miR-760,miR-920,miR-921,miR-935,miR-936,miR-937-3p,miR-938, miR-939-5p,miR-940,miR-1224-3p,miR-1225-5p,miR-1225-3p,miR-1226-5p,miR-1228-5p,miR-1228-3p,miR-1229-3p,mi R-1231,miR-1233-3p,miR-1234-3p,miR-1236-3p,miR-1237-3p,miR-1238 -3p,miR-513b-5p,miR-513c-5p,miR-320c,miR-1271-5p,miR-1298-5p,m iR-1178-3p,miR-1181,miR-1182,miR-1184,miR-1203,miR-120 4,miR-1207-5p,miR-1207-3p,miR-1285-3p,miR-1286,miR-1287-5p,miR -1291,miR-1293,miR-1294,miR-1297,miR-1303,miR-1304-5p,miR-1249- 3p,miR-1250-5p,miR-1260a,miR-1263,miR-1265,miR-1266-5p,miR-126 8a,miR-1269a,miR-1270,miR-1276,miR-1281,miR-1284,miR-1288-3p,mi R-1292-5p,miR-1306-3p,miR-1307-3p,miR-1322,miR-1322,miR-1825,m iR-1468-5p,miR-1469,miR-1471,miR-1538,miR-103b,miR-190 8-5p,miR-1909-5p,miR-1909-3p,miR-1910-5p,miR-19112- 3p,miR-1913,miR-1914-3p,miR-1915-3p,miR-103a-2-5p,m iR-224-3p,miR-365a-5p,miR-196b-3p,miR-49b-3p,miR-2113,miR-197 2,miR-1976,miR-2110,miR-151b,miR-49c-5p,miR-762,miR-761,miR-76 4,miR-548q,miR-2276-3p,miR-711,miR-2681-5p,miR-2682-5p, miR-2682-3p,miR-2861,miR-2909,miR-3122,miR-3124-5p,miR-3125,miR-3127-5p,miR-3130-5p,miR-378b,miR-466, miR-3137,miR-3138,miR-3141,miR-1273c,miR-3147,miR-314 8,miR-3150a-3p,miR-3151-5p,miR-3153,miR-3074-3p,miR-3154,miR-3 155a,miR-3158-3p,miR-3160-3p,miR-3162-5p,miR-3163,miR- 3165,miR-1260b,miR-3170,miR-3173-3p,miR-1193,miR-3174,miR-3175 ,miR-3176,miR-3178,miR-3180-3p,miR-3186-5p,miR-3186-3p ,miR-3187-3p,miR-3189-3p,miR-3191-3p,miR-3192-5p,miR- 3193,miR-3194-5p,miR-3195,miR-3196,miR-3197,miR-3198,miR-3199,m iR-3200-3p,miR-514b-3p,miR-3126-3p,miR-3065-3p,miR -4296,miR-4297,miR-378c,miR-4293,miR-4294,miR-4298,miR -4300,miR-4304,miR-4305,miR-4308,miR-4311,miR-4315,mi R-4316,miR-4314,miR-4318,miR-4319,miR-4317,miR-4322,miR-4321,mi R-4323,miR-4324,miR-4257,miR-4258,miR-4259,miR-4260,miR-4253,m iR-4254,miR-4255,miR-4252,miR-4326,miR-4261,miR-4265,m iR-4262,miR-4268,miR-4269,miR-4264,miR-4271,miR-4273,miR-4276, miR-4274,miR-4279,miR-4278,miR-4280,miR-4285,miR-4283,miR-4287,miR-4289,miR-4329,miR-4328,miR-2277-5p,miR-3605-5p,miR-3610,miR-361 4-5p,miR-3615,miR-3616-3p,miR-3619-5p,miR-3620-3p,miR-3621,miR-362, 2a-5p,miR-3622a-3p,miR-3622b-5p ,miR-3646,miR-3648,miR-3649,miR -3650,miR-3651,miR-3652,miR-3654,miR-3655,miR-3657,miR-3659,mi R-3660,miR-3661,miR-3663-5p,miR-3663-0,miR-3665,miR-3666,miR- 3667-5p,miR-3675-5p,miR-3675-3p,miR-3678-3p,miR-367 9-5p,miR-3679-3p,miR-3680-3p,miR-3681-3p,miR-3682-3p,miR-3685, miR-3689a-3p,miR-3690,miR-3691-5p,miR-3692-5p,miR-3713,miR-318 0,miR-3907,miR-3689b-3p,miR-3689c,miR-3911,miR-3913-5p,miR-391 7,miR-3918,miR-3919,miR-3150b-3p,miR-3925-5p,miR-676-5p,miR-392 8-3p,miR-3929,miR-3934-5p,miR-3936,miR-3937,miR-3940-3p,miR-39 44-3p,miR-374c-5p,miR-642b-3p,miR-550b-3p,miR-1268b,miR-378e,m iR-4420,miR-4421,miR-378g,miR-4425,miR-4428,miR-4429,miR-4430, miR-4431,miR-4433a-3p,miR-4435,miR-4436a,miR-4437,miR-4438,miR- 4439,miR-4440,miR-4441,miR-4444445-3p,miR-4446-3p,miR-44 47,miR-4448,miR-449,miR-4450,miR-4451,miR-4453,miR-4454,miR-4 455,miR-4456,miR-4458,miR-3135b,miR-4462,miR-4463,miR-4465,miR -4466,miR-4467,miR-4470,miR-4472,miR-4473,miR-4474-3p,miR-4475,miR-4476,miR-4478,miR-3689d,miR-3689f,miR-4479,miR-3155b,miR-4 481,miR-4483,miR-4484,miR-4486,miR-4487,miR-4488,miR-4489,miR- 4491,miR-4492,miR-4494,miR-4496,miR-4497,miR-4498,miR-4502,miR -4505,miR-4506,miR-2392,miR-4507,miR-4508,miR-4510,miR-4511,mi R-4513,miR-4514,miR-4516,miR-4521,miR-4523,miR-4524a� 5p,miR-4526,miR-4527,miR-4529-3p,miR-4530,miR-4533,miR-378i,mi R-4535,miR-4537,miR-4538,miR-4539,miR-4540,miR-3120-� p,miR-3129-3p,miR-3145-5p,miR-3150a-5p,miR-3152-5p,miR-3074-5p, miR-3157-3p,miR-3158-5p,miR-3160-5p,miR-3173-5p,mi R-3691-3p,miR-391-3p,miR-3922-5p,miR-3925-3p,miR- 3944-5p,miR-4423-5p,miR-4529-5p,miR-3960,miR-3975, miR-4634,miR-4635,miR-4638-5p,miR-4639-3p,miR-4640-5p,miR-4641, miR-4642,miR-4644,miR-4645-3p,miR-4646-3p,miR-4647 ,miR-4648,miR-4649-5p,miR-4650-3p,miR-4651,miR-4652-5p,miR-465 3-5p,miR-4654,miR-465-5p,miR-4656,miR-4657,miR-4658,miR-461- 3p,miR-4664-5p,miR-4664-3p,miR-465-3p,miR-467-5p,miR-4667-3p,miR-219b-5p,miR-469,miR-4670-5p,miR-4672,miR-4673 ,miR-4676-5p,miR-4676-3p,miR-4681,miR-4682,miR-4684-5 p,miR-4684-3p,miR-4685-3p,miR-4685-3p,miR-4687-5p,miR -4687-3p,miR-1343-3p,miR-4688,miR-4690-5p,miR-4691 -3p,miR-4694-3p,miR-4695-5p,miR-4697-5p,miR-4697-3p,m iR-4698,miR-4700-5p,miR-4700-3p,miR-4701-3p,miR-47 06,miR-4707-5p,miR-4707-3p,miR-4708-3p,miR-4709-5p ,miR-4709-3p,miR-4710,miR-4711-3p,miR-4712-5p,miR- 4713-3p,miR-4716-5p,miR-4716-3p,miR-3529-5p,miR-4717-5p,miR-47 17-3p,miR-4718,miR-4721,miR-4722-5p,miR-4722-3p,miR-4723-3p,mi R-4724-5p,miR-4724-3p,miR-4725-3p,miR-4726-5p,miR- 4726-3p,miR-4727-3p,miR-4728-3p,miR-4731-5p,miR-4731- 3p,miR-4732-3p,miR-4732-3p,miR-473-3p,miR-4734mi R-4736,miR-4737,miR-3064-3p,miR-4738-3p,miR-4739,m iR-4740-5p,miR-4741,miR-4743-5p,miR-122b-3p,miR-4745-5p,miR-47 46-3p,miR-4747-5p,miR-4747-3p,miR-4748,miR-4749-5p,miR-4749-3p,miR-4750-5p,miR-4753-3p,miR-371b-3p,miR-4754,miR-4 755-3p,miR-4756-5p,miR-4756-3p,miR-4758-5p,miR-475 9,miR-4761-3p,miR-4763-3p,miR-4764-3p,miR-4766-5p, miR-4767,miR-4768-5p,miR-4768-3p,miR-4769-3p,miR-4 773,miR-4776-5p,miR-4776-3p,miR-4778-5p,miR-4780,miR-4436b-5p, miR-4436b-3p,miR-4783-3p,miR-4783-3p,miR-4785,miR-246 7-3p,miR-4786-3p,miR-4787-5p,miR-4787-3p,miR-4788, miR-4793-3p,miR-4794,miR-4796-5p,miR-4797-3p,miR-48 00-5p,miR-4800-3p,miR-4804-3p,miR-642a-3p,miR-550a-3p 5p,miR-4433a-5p,miR-4482-3p,miR-49999-3p,miR-5000-5 p,miR-5001-5p,miR-5001-3p,miR-5002-3p,miR-5004-5p, miR-5004-3p,miR-5006-5p,miR-5006-3p,miR-5007-5p,miR-5008-5p,mi R-5010-5p,miR-5088-5p,miR-5090,miR-5093,miR-5187-5p,m iR-5188,miR-5189-5p,miR-5190,miR-5192,miR-5194,miR-5196-5p,miR -5196-3p,miR-5197-5p,miR-4524b-3p,miR-5571-3p,miR -5100,miR-5572,miR-664b-3p,miR-5580-5p,miR-5580-3p,miR-5581-3p,miR-5584-3p,miR-5585-3p,miR-1295b-3p,miR-5588-5p, miR-5588-3p,miR-5589-5p,miR-5591-3p,miR-5684,miR-5685,miR-5681 b,miR-5690,miR-5694,miR-5696,miR-5698,miR-5702,miR-5703,miR-57 04,miR-5705,miR-5708,miR-197-5p,miR-204-3p,miR-211-3p,miR-212- 5p,miR-301a-5p,miR-345-3p,miR-584-3p,miR-60-3p,miR -1185-2-3p,miR-766-5p,miR-1285-5p,miR-1304-3p,miR- 1255b-2-3p,miR-1306-5p,miR-3184-3p,miR-3191-5p,miR -550b-2-5p,miR-365b-5p,miR-1185-1-3p,miR-3190-3p,miR-216a-3p,m iR-381-5p,miR-495-5p,miR-503-3p,miR-937-5p,miR-939-3p,miR-122 7-5p,miR-1229-5p,miR-1233-5p,miR-1236-5p,miR-1237-5p,miR-1238- 5p,miR-3617-3p,miR-3620-5p,miR-3927-5p,miR-3934-3p,miR-4632-5p ,miR-4743-3p,miR-5089-3p,miR-5739,miR-6068,miR-6069,m iR-6071,miR-6072,miR-6074,miR-6075,miR-6076,miR-6080, miR-6081,miR-6083,miR-6085,miR-6086,miR-6089,miR-6090 ,miR-6124,miR-6125,miR-6126,miR-6127,miR-6129,miR-6130,miR-613 1,miR-6132,miR-6133,miR-6134,miR-6165,miR-6499-3p,miR-548ay-3p,miR-6500-5p,miR-6500-3p,miR-6501-3p,miR-6502-5p,miR- 6503-3p,miR-6504-3p,miR-6505-3p,miR-6506-5p,miR-6508-5p,miR-6509, -5p,miR-6510-5p,miR-6511a-5p,miR-6512-3p,miR-6513-5p,miR-6513- 3p,miR-6514-3p,miR-6515-5p,miR-6515-3p,miR-6715a-3p ,miR-6715b-5p,miR-6716-5p,miR-6716-3p,miR-6717-5p,miR-6511b-5p ,miR-6511b-3p,miR-6718-5p,miR-6719-3p,miR-6721-5p,m iR-6722-3p,miR-6724-5p,miR-892c-3p,miR-208a-5p,miR -210-5p,miR-128-1-5p,miR-134-3p,miR-370-5p,miR-328-5p,miR-433-� p,miR-487a-5p,miR-489-5p,miR-494-5p,miR-504-3p,miR-487b-5p,miR -579-5p,miR-585-5p,miR-598-5p,miR-619-5p,miR-656-5p,miR-668-5p, miR-1296-3p,miR-1301-5p,miR-1298-3p,miR-891a-3p,miR-874-5p,miR -889-5p,miR-887-5p,miR-216b-3p,miR-942-3p,miR-1180-5p,miR-1287- 3p,miR-1251-3p,miR-1266-3p,miR-1288-5p,miR-1908-3p,miR-190-3p ,miR-3151-3p,miR-3192-3p,miR-500b-3p,miR-3928-5p,miR-1343-5p,mi R-5088-3p,miR-5189-3p,miR-6720-5p,miR-6726-3p,miR- 6727-5p,miR-6727-3p,miR-6728-5p,miR-672 9-3p,miR-6730-5p,miR-6730-3p,miR-6731-5p,miR-6732-5p,miR-6732- 3p,miR-673-3p,miR-6734-5p,miR-6735-3p,miR-6736-3p,miR-6737-5p,miR-6738-5p,miR-6739-3p,miR-6740-5p,mi R-6740-3p,miR-6741-5p,miR-6741-3p,miR-6742-5p,miR- 6743-3p,miR-6744-3p,miR-6747-3p,miR-6748-5p,miR-67 48-3p,miR-6749-5p,miR-6749-3p,miR-6750-3p,miR-6751- 5p,miR-6751-3p,miR-6752-3p,miR-6753-5p,miR-6754-5p ,miR-6755-5p,miR-6755-3p,miR-6756-5p,miR-6756-3p,mi R-6758-5p,miR-6758-3p,miR-6759-5p,miR-6759-3p,miR- 6760-3p,miR-6761-5p,miR-6762-3p,miR-676 3-3p,miR-6764-3p,miR-6765-5p,miR-6766- 3p,miR-6767-5p,miR-6768-5p,miR-6769a-3p,miR-6770- 5p,miR-6770-3p,miR-6771-5p,miR-6772-5p,miR-6772-3p,miR-6773-3p ,miR-6774-3p,miR-6775-5p,miR-6776-5p,miR-6776-3p,mi R-6777-5p,miR-6777-3p,miR-6778-5p,miR-6778-3p,miR- 6779-3p,miR-6781-5p,miR-6781-3p,miR-6782-3p,miR-678 3-5p,miR-6784-5p,miR-6784-3p,miR-6785-3p,miR-6786- 5p,miR-6786-3p,miR-6787-3p,miR-6788-5p,miR-6789-5p,miR-6789-3p,miR-6790-5p,miR-6791-5p,miR-6791-3p,miR-6792-5p,mi R-6792-3p,miR-6793-5p,miR-6794-5p,miR-6796-5p,miR- 6797-5p,miR-6797-3p,miR-6798-5p,miR-6798-3p,miR-6799-5p,miR-68 00-5p,miR-680-3p,miR-6801-3p,miR-6802-3p,miR-6803p 5p,miR-6803-3p,miR-6804-3p,miR-6805-5p,miR-6805-3p ,miR-6806-5p,miR-6807-5p,miR-6808-5p,miR-6809-3p,mi R-6810-5p,miR-6810-3p,miR-6812-5p,miR-6813-3p,miR- 6814-5p,miR-6815-3p,miR-6816-5p,miR-6816-3p,miR-6817-5p,miR-681 7-3p,miR-6818-3p,miR-6819-3p,miR-6820-5p,miR-6820-3p,miR-6821- 5p,miR-6821-3p,miR-6822-5p,miR-6823-3p ,miR-6824-3p,miR-6825-5p,miR-6825-3p,miR-6826-3p,m iR-6827-5p,miR-6829-5p,miR-6829-3p,miR-6830-3p,miR- 6831-5p,miR-6832-3p,miR-6832-3p,miR-6833-30,miR-68 34-5p,miR-6780b-3p,miR-6780b-3p,miR-6836-3p,miR-683 7-5p,miR-6838-5p,miR-6839-5p,miR-6840-3p,miR-6842-5p,miR-6842- 3p,miR-6843-3p,miR-6845-3p,miR-6846-5p,miR-6846-3p,miR-6847-3p,miR-6848-5p,miR-6848-3p,miR-6849-5p,m iR-6849-3p,miR-6850-5p,miR-6850-3p,miR-6851-5p,miR -6852-3p,miR-6853-5p,miR-6854-3p,miR-6855-3p,miR-6 856-5p,miR-6856-3p,miR-6857-5p,miR-6858-5p,miR-685 9-5p,miR-6859-3p,miR-6769b-5p,miR-6860,miR-6861-3p ,miR-6862-3p,miR-6862-3p,miR-6863,miR-6867-5p,miR- 6867-3p,miR-6868-5p,miR-68689-5p,miR-68 70-3p,miR-6871-5p,miR-6873-5p,miR-6874-3p,miR-6875 -5p,miR-6876-5p,miR-6876-3p,miR-6877-5p,miR-6877-3 p,miR-6878-3p,miR-6879-5p,miR-6879-3p,miR-6880-5p,miR-6880-3p, miR-6881-5p,miR-6882-3p,miR-6883-3p,miR-6884-5p,mi R-6884-3p,miR-6885-3p,miR-6886-5p,miR-6886-3p,miR- 6888-5p,miR-6889-3p,miR-6890-5p,miR-6890-3p,miR-68 91-5p,miR-6891-3p,miR-6892-5p,miR-6892-3p,miR-6893 -3p,miR-6894-3p,miR-6895-5p,miR-6895-3p,miR-7106-� p,miR-7106-3p,miR-7107-5p,miR-7108-5p,miR-7108-3p,miR-7109-5p,miR-7109-3p,miR-7110-5p,miR-7111-3p,mi R-7112-5p,miR-7113-5p,miR-7113-3p,miR-7114-3p,miR- 7150,miR-7151-5p,miR-7151-3p,miR-7152-5p,miR-7154-3p,miR-7155- 5p,miR-7155-3p,miR-7156-5p,miR-7156-3p,miR-7158-5p,miR-7160- ,miR-7162-3p,miR-7515,miR-7702,miR-7704,miR-7706,miR-7843-5p,m iR-4433b-3p,miR-1273h-5p,miR-6516-5p,miR-7844-5p, miR-7845-5p,miR-7846-3p,miR-7848-3p,miR-7850-5p,mi R-7851-3p,miR-7854-3p,miR-7856-5p,miR-8052,miR-8055 ,miR-8057,miR-8059,miR-8060,miR-8062,miR-8063,miR-8064,miR-806 9,miR-8070,miR-8071,miR-8072,miR-8073,miR-8074,miR-8075,miR-80 77,miR-8078,miR-8079,miR-8080,miR-8082,miR-8083,miR-8 085,miR-8089,miR-128-2-5p,miR-7973,miR-7974,miR-7975,miR-7976,m iR-7977,miR-1249-5p,miR-4485-5p,miR-8485,miR-9500,miR-103a-1-5 p,miR-217-3p,miR-135a-2-3p,miR-375-5p,miR-498-3p,miR-9718,miR- 9899,miR-9902,miR-1843,miR-9986,miR-10392-3p,miR- 10394-5p,miR-10394-3p,miR-10395-5p,miR-10396a-3p,miR-10397-5p,miR-10398-5p,miR-10398-3p,miR-10400-3p,miR-1 0401-5p,miR-10401-3p,miR-10396b-3p,miR-10522-5p,miR-105, 23-5p, miR-10527-5p, miR-11181-3p, miR-11399, miR-11400, miR-11401, miR-3059-5p , miR-3059-3p, miR-3085-3p, miR-6529-5p, miR-6529-3p, miR-9851-5p, miR-12114, mi miR-12115, miR-12116, miR-12117, miR-12118, miR-12119, miR-12120, miR-12121, miR-12122, miR-12124, miR-12125, miR-12127, miR-12128, and miR-12131; The urine is from a subject having or suspected of having lung cancer. method.

27. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having metal oxide nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, let-7e-5p, miR-105-5p, miR-192-5p, miR-198, miR-129-5p, miR-187-3p, miR-210-3p, miR-212-3p, miR-214-3p, miR-200b-3p, miR-125b-5p, miR-138-5p, miR-134-5p, miR-184, miR-185-5p, miR-206, miR-106b-5p, miR-34c-5p, miR-99b-5p, miR-296-5p, miR-130b-3p, miR-302c-5p, miR-370-3p, miR-373-3p, miR-378a-3p, miR-382-5p, miR-340-3p, miR-342-3p, miR-337-3p, miR-323a-3p, miR-324-5p, miR-346, miR-422a, miR-425-3p, miR-369-5p, miR-323b-5p, miR-409-3p, miR-412-3p, miR-485-5p, miR-485-3p, miR-488-5p, miR-491-5p, miR-202-3p, miR-492, miR-432-3p, miR-494-3p, miR-512-5p, miR-512-3p, miR-498-5p, miR-520e-3p, miR-515-3p, miR-519c-5p, miR-523-5p, miR-518e-5p, miR-522-5p, miR-519a-5p, miR-519b-5p, miR-526b-5p, miR-525-5p, miR-518f-3p, miR-520b-3p, miR-526a-5p, miR-520c-5p, miR-518d-5p, miR-518c-5p, miR-519d-3p, miR-520d-5p, miR-516b-3p, miR-516a-3p, miR-501-5p, miR-513a-5p, miR-510-5p, miR-18a-3p, miR-551a, miR-92b-3p, miR-558, miR-564, miR-551b-3p, miR-572, miR-574-3p, miR-575, miR-583, miR-550a-3p, miR-595, miR-596, miR-601, miR-602, miR-604, miR-608, miR-610, miR-612, miR-614,miR-615-3p,miR-616-5p,miR-617,miR-622,miR-623,miR-629-3p,miR-6 32,miR-636,miR-637,miR-638,miR-639,miR-646,miR-650,miR-661,miR -663a,miR-654-5p,miR-657,miR-658,miR-421,miR-542-5p,miR-363-5p ,miR-668-3p,miR-769-3p,miR-766-3p,miR-770-5p,miR-297,let-7d-3p, miR-15a-3p,miR-21-3p,miR-23a-5p,miR-25-5p,miR-26b-3p,miR-92a-2 -5p,miR-30c-2-3p,miR-139-3p,miR-183-3p,miR-187-5p,miR-214-5p,m iR-200b-5p,miR-30b-3p,miR-130a-5p,miR-135a-3p,miR-138-2-3p,miR -125a-3p,miR-125b-2-3p,miR-138-1-3p,miR-149-3p,miR-150-3p,miR-� 85-3p,miR-186-3p,miR-193a-5p,miR-200c-5p,miR-155-3p,miR-194-3p ,miR-34b-3p,miR-34c-3p,miR-296-3p,miR-130b-5p,miR-361-3p,miR-3 02d-5p,miR-377-5p,miR-342-5p,miR-323a-5p,miR-338-5p,miR-424-3p ,miR-18b-3p,miR-20b-3p,miR-483-5p,miR-486-3p,miR-193 b-5p,miR-05-5p,miR-508-5p,miR-92b-5p,miR-51b-5p,miR-574-5p,m iR-550a-5p,miR-593-3p,miR-615-5p,miR-625-3p,miR-629-5p,miR-671- 3p,miR-891a-5p,miR-300,miR-892b,miR-541-3p,miR-744- 5p,miR-885-5p,miR-885-3p,miR-877-5p,miR-887-3p,miR-665,miR-760,miR-920,miR-921,miR-935,miR-936,miR-937-3p,miR-938,miR-939-5p, miR-940,miR-943,miR-1224-5p,miR-1224-3p,miR-1225-5 p,miR-1226-5p,miR-1228-5p,miR-1228-3p,miR-1233-3p,miR -1237-3p,miR-1238-3p,miR-513b-5p,miR-320c,miR-1271-5p, miR-1301-3p,miR-1298-5p,miR-1178-3p,miR-1182,miR-1184 ,miR-1203,miR-1204,miR-1207-5p,miR-1285-3p,miR-1293,miR-1303,m iR-1249-3p,miR-1250-5p,miR-548g-3p,miR-1266-5p,miR-1268a,miR-1 269a,miR-1270,miR-1276,miR-1292-5p,miR-1306-3p,miR-1307-3p,miR- 1321,miR-1468-5p,miR-1469,miR-1471,miR-153 8,miR-1908-5p,miR-1909-5p,miR-1909-3p,miR-1910-5p,miR-1912-3p, miR-1913,miR-1914-3p,miR-103a-2-5p,miR-365a-5p,miR -196b-3p,miR-449b-3p,miR-1972,miR-2110,miR-49c-5p,miR-762,miR- 670-5p,miR-761,miR-764,miR-2116-5p,miR-548q,miR-2276-3p,miR-22 77-3p,miR-711,miR-718,miR-2682-5p,miR-449c-3p,miR-3122,miR-312 4-5p,miR-3126-5p,miR-3130-30-5p,miR-3131,miR-3132,miR -3133,miR-466,miR-3137,miR-3138,miR-3141,miR-3147,miR-3150a-3p,miR-3151-5p,miR-3153,miR-3074-3p,miR-3155a,miR-3158-3p,miR-316 1,miR-3162-5p,miR-3163,miR-3164,miR-3160b,miR-3173-3p ,miR-1193,miR-3176,miR-3177-3p,miR-31780-3p,miR-3185,m iR-3186-3p,miR-3187-3p,miR-3189-3p,miR-3192-5p,miR -3195,miR-3196,miR-3197,miR-3198,miR-3199,miR-3202,miR-3126-3p ,miR-4296,miR-4297,miR-4299,miR-43004,miR-430 5,miR-4306,miR-4307,miR-4308,miR-4313,miR-4316,miR-4314,miR-43 19,miR-4317,miR-4322,miR-4321,miR-4323,miR-4257,miR-4 258,miR-4259,miR-4260,miR-4253,miR-4255,miR-4252,miR- 4326,miR-4327,miR-4261,miR-4265,miR-426,miR-4262,miR -4268,miR-4269,miR-4276,miR-4274,miR-4280,miR-4285,miR-4289,mi R-2277-5p,miR-3200-5p,miR-3605-3p,miR-3610,miR-361 2,miR-3614-5p,miR-3616-3p,miR-3619-5p,miR-3621,miR-3622a-5p,mi R-3622a-3p,miR-3622b-5p,miR-3646,miR-3648,miR-3650,miR-3651,mi R-3652,miR-3654,miR-36559,miR-360,miR-363-5p,miR-366 3-3p,miR-3665,miR-367-3p,miR-367-3p,miR-3677-3p,miR-3679-5p,miR-3679-3p,miR-3682-3p,miR-3685,miR-3689a-3p,miR- 3691-5p,miR-3713,miR-3714,miR-3180,miR-3689b-3p,miR-3689c,miR- 3917,miR-3918,miR-3150b-3p,miR-3925-5p,miR-3928-3p,miR-3934-5p ,miR-3935,miR-3936,miR-3937,miR-3944-3p,miR-3945,miR-550b-3p,mi R-1268b,miR-4421,miR-4428,miR-4429,miR-4430,miR-4431,miR-4433a -3p,miR-4435,miR-4436a,miR-4439,miR-4440,miR-4441,miR-4443,miR- 4444,miR-4446-3p,miR-4447,miR-4448,miR-449,miR-4450,miR-4451, miR-4453,miR-4454,miR-4456,miR-4458,miR-3135b,miR-4462 ,miR-4463,miR-4465,miR-4466,miR-4467,miR-4470,miR-4472,miR-447 4-3p,miR-4475,miR-4476,miR-3689d,miR-4479,miR-3155b,miR-4481,m iR-4483,miR-4484,miR-4485-3p,miR-4486,miR-4487,miR-4488,miR-44 89,miR-4492,miR-4496,miR-4497,miR-4498,miR-4499,miR-4502,miR-45 05,miR-4506,miR-2392,miR-4507,miR-4508,miR-4510,miR-4 513,miR-4514,miR-4515,miR-4516,miR-4525,miR-4 530,miR-4531,miR-4533,miR-4535,miR-1587,miR-4538,miR- 4539,miR-4540,miR-3120-5p,miR-3150a-5p,miR-3074-5p,miR-3156-3p,miR-3160-5p,miR-3162-3p,miR-3173-5p,miR-3619-3p,miR-3922-5p,m iR-3940-5p,miR-3944-5p,miR-4520-5p,miR-4529-5p,miR-3960,miR-4634,miR-4635, miR-4639-3p,miR-4640-5p,miR-4642,miR-4646-5p,miR-4 647,miR-4648,miR-4650-3p,miR-4651,miR-4652-5p,miR-4653-5p,miR- 4653-3p,miR-4654,miR-4655-5p,miR-4657,miR-4658,miR-4664-5p,miR -4664-3p,miR-4665-5p,miR-465-3p,miR-467-5p,miR-219b-5p,miR-46 69,miR-4670-5p,miR-4673,miR-4674,miR-4676-5p,miR-4681,miR-4682 ,miR-4684-5p,miR-4684-3p,miR-4685-3p,miR-4687-5p,miR-1343-3p,mi R-4688,miR-4690-5p,miR-4690-3p,miR-4691-5p,miR-4692,miR-4695-� p,miR-4700-5p,miR-4701-3p,miR-4707-5p,miR-4707-3p,miR- 4708-5p,miR-4708-3p,miR-203b-5p,miR-4710,miR-4714- 5p,miR-4716-3p,miR-4717-5p,miR-4717-3p,miR-4720-5p, miR-4722-3p,miR-4724-5p,miR-4725-5p,miR-4 726-3p,miR-4727-3p,miR-4728-5p,miR-4728-3p,miR-4730,miR-4731-3p ,miR-4732-3p,miR-4734,miR-47364-5p,miR-306 4-3p,miR-4740-5p,miR-4740-3p,miR-4741,miR-4743-5p,m iR-122b-3p,miR-4745-5p,miR-4746-3p,miR-4747-3p,miR -4748,miR-4749-5p,miR-4749-3p,miR-475p,miR-371b-5p,miR-4754,miR-4755-3p,miR-4758-5p,miR-4764-3p,miR-4767,miR- 4769-5p,miR-4776-5p,miR-4776-3p,miR-4780,miR-4436b-5p,miR-4436 b-3p,miR-4781-5p,miR-4783-3p,miR-4783-3p,miR-4785,miR-2467-3p, miR-4786-5p,miR-4786-3p,miR-4786-3p,miR-4793-3p,miR-4800-5p,mi R-4800-3p,miR-4801,miR-4804-3p,miR-550a-3-5p,miR- 4482-3p,miR-4999-5p,miR-5001-5p,miR-5002-3p,miR-50 04-5p,miR-5004-3p,miR-5006-5p,miR-5009-3p,miR-5010-5p,miR-5088 -5p,miR-5090,miR-5093,miR-5187-5p,miR-5188,miR-5189-5p,miR-519 0,miR-5193,miR-5195-5p,miR-5196-5p,miR-571-3p,miR-5100,miR-5 572,miR-664b-3p,miR-5580-3p,miR-5581-3p,miR-5584-3 p,miR-5585-3p,miR-5587-5p,miR-5588-5p,miR-5589-5p, miR-5685,miR-5681b,miR-5698,miR-5703,miR-5705,miR-197-5p,miR-2 04-3p,miR-211-3p,miR-301a-5p,miR-345-3p,miR-584-3p,miR-659-5p, miR-1185-2-3p,miR-766-5p,miR-873-3p,miR-1285-5p,miR-1247-3p,mi R-1255b-2-3p,miR-3191-5p,miR-64 2b-5p,miR-550b-2-5p,miR-365b-5p ,miR-1185-1-3p,miR-3190-3p,miR-937-5p,miR-1227-5p,miR-1236-5p,miR-1237-5p,miR-1238-5p,miR-1292-3p,miR-3617-3p,mi R-3934-3p,miR-4632-5p,miR-4750-3p,miR-5739,miR-5787,miR-6068,mi R-6070,miR-6071,miR-6072,miR-6074,miR-6075,miR-6076,miR-6080,m iR-6081,miR-6083,miR-6084,miR-6085,miR-6089,miR-6090,m iR-6124,miR-6125,miR-6126,miR-6127,miR-6129,miR-6130,miR-6131, miR-6132,miR-6133,miR-6134,miR-616500-5p,miR-6500-3p,miR -6501-5p,miR-6501-3p,miR-6503-3p,miR-6504-3p,miR-6508-5p,miR-6 509-3p,miR-6511a-5p,miR-6512-3p,miR-6513-5p,miR-6514-5p,miR-651 4-3p,miR-6515-5p,miR-6515-3p,miR-6716-3p,miR-6717 -5p,miR-6511b-5p,miR-6718-5p,miR-6721-5p,miR-6722-5p,miR-6722-3 p,miR-6724-5p,miR-210-5p,miR-128-1-5p,miR-134-3p,mi R-487a-5p,miR-489-5p,miR-504-3p,miR-487b-5p,miR-585-5p,miR-605� 3p,miR-619-5p,miR-656-5p,miR-668-5p,miR-1296-3p,miR-1301-5p,mi R-1298-3p,miR-874-5p,miR-1180-5p,miR-548j-3p,miR-125 0-3p,miR-1266-3p,miR-1288-5p,miR-1908-3p,miR-3192- 3p,miR-500b-3p,miR-3928-5p,miR-1343-5p,miR-5088-3p,miR-5189-3p,miR-6720-5p,miR-6726-5p,miR-6728-5p,miR-6728-3p,mi R-6729-5p,miR-6729-3p,miR-6730-3p,miR-6731-5p,miR- 6731-3p,miR-6732-5p,miR-6734-5p,miR-6736-5p,miR-67 36-3p,miR-6737-5p,miR-6738-3p,miR-6740-5p,miR-6740- 3p,miR-6741-5p,miR-6742-5p,miR-6743-5p,miR-6746-5p,mi R-6747-5p,miR-6748-5p,miR-6749-5p,miR-6751-5p,miR- 6752-5p,miR-6752-3p,miR-6753-5p,miR-6753-3p,miR-67 56-5p,miR-6759-5p,miR-6760-5p,miR-6760-3p,miR-6761- 5p,miR-6762-5p,miR-6762-3p,miR-6763-5p,miR-6763-3p ,miR-6765-5p,miR-6765-3p,miR-6766-5p,m iR-6768-5p,miR-6769a-5p,miR-6770-5p,miR-6770-3p,miR-6772-5p,mi R-6772-3p,miR-6774-3p,miR-6776-5p,miR-6776-3p,miR-6 777-5p,miR-677-3p,miR-6778-5p,miR-6778-3p,miR-679-3p,miR-678 0a-5p,miR-6780a-3p,miR-6781-5p,miR-6781-3p,miR-6782-5p,miR-678 3-5p,miR-6784-5p,miR-6784-3p,miR-6785-3p,miR-6786- 5p,miR-6787-3p,miR-6788-5p,miR-6789-5p,miR-6789-3p,miR-6790-5p,miR-6791-3p,miR-6792-5p,miR-6792-3p,mi R-6793-5p,miR-6794-5p,miR-6795-5p,miR-6795-3p,miR-6796-5p,miR- 6796-3p,miR-6797-5p,miR-6798-5p,miR-6798-3p,miR-6800-5p,miR-68 00-3p,miR-6803-3p,miR-6804-3p,miR-6805-5p,miR-6805p 3p,miR-6806-5p,miR-6808-5p,miR-6809-3p,miR-6810-5p ,miR-6810-3p,miR-6812-5p,miR-6813-3p,miR-6814-5p,mi R-6815-5p,miR-6816-3p,miR-6817-5p,miR-6819-3p,miR- 6820-5p,miR-6820-3p,miR-6821-3p,miR-682 3-5p,miR-6824-5p,miR-6825-5p,miR-6827-5p,miR-6829-5p,miR-6829- 3p,miR-6830-5p,miR-6830-3p,miR-6832-5p,miR-6832-3p ,miR-6833-5p,miR-683-3p,miR-6834-5p,miR-6780b-3p ,miR-6836-3p,miR-6837-5p,miR-6837-3p,mi R-6839-5p,miR-6840-3p,miR-6842-5p,miR-6843-3p,miR- 6845-3p,miR-6846-5p,miR-6847-3p,miR-6848-5p,miR-684 9-5p,miR-6849-3p,miR-6850-5p,miR-6850-3p,miR-6852-5p,miR-6852- 3p,miR-6855-5p,miR-6855-3p,miR-6856-5p,miR-6856-3p,miR-6857-5p,miR-6859-5p,miR-6859-3p,miR-6769b-5p,miR-6860,miR-6861-5p ,miR-6862-5p,miR-6867-3p,miR-6868-3p,miR-6869-5p,miR-6870, -5p,miR-6871-5p,miR-6872-5p,miR-6873-5p,miR-6874-5p,miR-6875-� p,miR-6875-3p,miR-6876-5p,miR-6877-3p,miR-6878-3p,m iR-6879-5p,miR-6879-3p,miR-6880-5p,miR -6882-3p,miR-6883-3p,miR-6883-3p,miR-6887-5p,miR-68 87-3p,miR-6889-5p,miR-6891-3p,miR-6892-5p,miR-6892 -3p,miR-6893-3p,miR-6894-3p,miR-6895-5p ,miR-7106-5p,miR-7107-5p,miR-7108-5p,miR-7108-3p,miR-7109-3p,m iR-7110-5p,miR-711-5p,miR-7112-5p,miR-7113-5p,miR-7114-5p,miR- 7114-3p,miR-7150,miR-7151-3p,miR-7152-5p,miR-7154-3p,miR-7155- 5p,miR-7156-3p,miR-7160-5p,miR-7162-3p,miR-7515,miR-7702,miR-77 04,miR-7843-5p,miR-4433b-3p,miR-1273h-5p,miR-6516 -5p,miR-7845-5p,miR-7846-3p,miR-7851-3p,miR-7855-5p ,miR-7856-5p,miR-8052,miR-8057,miR-8059,miR-8060,miR-8063,miR- 8064,miR-8069,miR-8070,miR-8071,miR-8072,miR-8073,miR-8074,miR- 8075,miR-8077,miR-8079,miR-8082,miR-8085,miR-8087,miR -80889,miR-7974,miR-7975,miR-7976,miR-7977,miR-4485-5p,Selected from the group (Hemo) consisting of miR-8485, miR-103a-1-5p, miR-196a-1-3p, miR-217-3p, miR-135a-2-3p, miR-9718, miR-9898, miR-9902, miR-1843, miR-10226, miR-10392-5p, miR-10392-3p, miR-10394-3p, miR-10395-5p, miR-10396a-5p, miR-10396a-3p, miR-10398-5p, miR-10398-3p, miR-10400-5p, miR-10400-3p, miR-10401-5p, miR-10401-3p, miR-10396b-5p, miR-10396b-3p, miR-10522-5p, miR-10526-3p, miR-10527-5p, miR-11181-3p, miR-11399, miR-11400, miR-11401, miR-3059-3p, miR-3085-5p, miR-3085-3p, miR-6529-5p, miR-9851-5p, miR-12114, miR-12115, miR-12116, miR-12118, miR-12119, miR-12120, miR-12122, miR-12124, miR-12126, miR-12127, and miR-12128,, The urine is from a subject having or suspected of having lung cancer. method.

28. 1. A method for analyzing a urine sample, comprising: contacting a urine sample with nanowires in a nanowire-integrated fluidic device having metal oxide nanowires; Extracting the microRNA captured on the nanowire; and and determining whether or not a specific microRNA is contained in the extracted microRNA by contacting the extracted microRNA with a nucleic acid containing a sequence capable of hybridizing to the microRNA; The specific microRNA includes at least let-7a-5p, or In addition to let-7a-5p, let-7b-5p, miR-25-3p, miR-28-5p, miR-29a-3p, miR-29b-3p, miR-105-5p, miR-192-5p, miR-196a-5p, miR-197-3p, miR-198, miR-199a-5p, miR-129-5p, miR-30d-5p, miR-147a, miR-10a-5p, miR-34a-5p, miR-181a-5p, miR-181b-5p, miR-187-3p, miR-199b-5p, miR-204-5p, miR-210-3p, miR-211-5p, miR-212-3p, miR-214-3p, miR-221-3p, miR-223-3p, miR-200b-3p, miR-23b-3p, miR-30b-5p, miR-122-5p, miR-124-3p, miR-125b-5p, miR-138-5p, miR-125a-5p, miR-134-5p, miR-149-5p, miR-184, miR-185-5p, miR-194-5p, miR-206, miR-106b-5p, miR-34c-5p, miR-299-3p, miR-99b-5p, miR-296-5p, miR-130b-3p, miR-365a-3p, miR-365b-3p, miR-302c-5p, miR-370-3p, miR-373-5p, miR-373-3p, miR-378a-3p, miR-380-3p, miR-382-5p, miR-340-3p, miR-330-3p, miR-328-3p, miR-342-3p, miR-337-3p, miR-324-5p, miR-324-3p, miR-338-3p, miR-133b, miR-325, miR-346, miR-196b-5p, miR-422a, miR-425-3p, miR-448, miR-449a, miR-191-3p, miR-200a-5p, miR-369-5p, miR-433-3p, miR-323b-5p, miR-409-3p, miR-412-3p, miR-483-3p, miR-484, miR-485-5p, miR-485-3p, miR-486-5p, miR-488-5p, miR-489-3p, miR-491-5p, miR-202-3p, miR-492, miR-432-3p, miR-494-3p,miR-497-5p,miR-512-5p,miR-498-5p,miR-515-5p,miR-519c-5p,miR-52 3-5p,miR-518e-5p,miR-522-5p,miR-519a-5p,miR-519b-5p,miR-526b-5p ,miR-525-5p,miR-525-3p,miR-518b,miR-518c-5p,miR-519d-3p,miR-52 0d-3p,miR-520g-3p,miR-516b-3p,miR-516b-3p,miR-516a-3p,miR-518a- 3p,miR-502-5p,miR-504-5p,miR-513a-5p,miR-506-3p,miR-510-5p,miR -532-5p,miR-299-5p,miR-18a-3p,miR-487b-3p,miR-551am iR-54,miR-92b-3p,miR-557,miR-558,miR-563,miR-564,miR-551b-3p, miR-572,miR-574-3p,miR-575,miR-579-3p,miR-580-3p,miR-583,miR-58 4-5p,miR-585-3p,miR-588,miR-589-3p,miR-550a-3p,miR-595,miR-601 ,miR-603,miR-604,miR-605-5p,miR-608,miR-610,miR-612,miR-614,miR -615-3p,miR-61-5p,miR-617,miR-622,miR-628-3p,miR-629-3p,miR-6 32,miR-634,miR-635,miR-636,miR-637,miR-638,miR-639,miR-642a-5p, miR-644a,miR-650,miR-548d-3p,miR-661,miR-663a,miR-449b-5p,miR- 654-5p,miR-657,miR-658,miR-421,miR-542-5p,miR-671-5p,miR-668-3p ,miR-767-3p,miR-454-5p,miR-769-5p,miR-769-3p,miR-76 5,miR-770-5p,miR-297,let-7b-3p, let-7d-3p,let-7f-1-3p,miR-21-3p,miR-23a-5p,miR-25-5p,miR-26b-3p,miR-92a-2-5p,miR-29b-2-5p,miR- 106a-3p,miR-16-2-3p,miR-192-3p,miR-129-1-3p,miR-139-3p,miR-183 -3p,miR-187-5p,miR-214-5p,miR-222-5p,miR-200b-5p,miR-15b-3p,mi R-30b-3p,miR-124-5p,miR-125b-1-3p,miR-135a-3p,miR-138-2-3p,miR -140-3p,miR-125a-3p,miR-125b-2-3p,miR-127-5p,miR-129-2-3p,miR- 138-1-3p,miR-149-3p,miR-150-3p,miR-185-3p,miR-186-3p,miR-193a- 5p,miR-200c-5p,miR-194-3p,miR-30c-1-3p,miR-219a-2-3p,miR-34b-3 p,miR-34c-3p,miR-99b-3p,miR-296-3p,miR-130b-5p,miR-361-3p,miR- 302d-5p,miR-371a-5p,miR-30-5p,miR-342-5p,miR-323a-5p,miR-15a -5p,miR-338-5p,miR-424-3p,miR-18b-3p,miR-20b-3p,miR -431-3p,miR-483-5p,miR-486-3p,miR-490-5p,miR-146b-3p,miR-193b- 5p,miR-516a-5p,miR-505-5p,miR-508-5p,miR-532-3p,miR-92b-5p,miR -551b-5p,miR-574-5p,miR-50a-5p,miR-593-3p,miR-615-5p,miR-625� 3p,miR-629-5p,miR-654-3p,miR-671-3p,miR-891a-5p,miR-300,miR-87 4-3p,miR-888-3p,miR-892b,miR-541-5p,miR-541-3p,miR-876-3p,miR- 708-5p,miR-147b-3p,miR-744-5p,miR-885-5p,miR-885-3p,miR-877-5p,miR-877-3p,miR-887-3p,miR-665,miR-760,miR-920,miR- 921,miR-933,miR-935,miR-936,miR-937-3p,miR-938,miR-939-5p,miR- 940,miR-943,miR-1224-5p,miR-1224-3p,miR-1225-3p,mi R-1226-3p,miR-1226-3p,miR-1227-3p,miR-1228-5p,miR-1228-3p,miR- 1229-3p,miR-1231,miR-123-3p,miR-1234-3p,miR-1236-3p,miR-1237- 3p,miR-1238-3p,miR-513b-5p,miR-513c-5p,miR-320b,miR-320c,miR-1 271-5p,miR-1301-3p,miR-1298-5p,miR-1178-3p,miR-1182,m iR-1184,miR-1202,miR-1203,miR-1204,miR-1207-5p,miR-1207-3p,miR -1285-3p,miR-1286,miR-1287-5p,miR-12893,miR-1294,miR- 1303,miR-1304-5p,miR-1249-3p,miR-1250-5p,miR-1257,miR-1260a,mi R-548g-3p,miR-1263,miR-1266-5p,miR-1267,miR-1268a,miR-1269a,mi R-1270,miR-1275,miR-1276,miR-1281,miR-1284,miR-1288-3p,miR-129 2-5p,miR-1255b-5p,miR-664a-3p,miR-1306-3p,miR-1307-3p,miR-1321 ,miR-1322,miR-320d,miR-1825,miR-1468-5p,miR-675-3p,miR-1469,mi R-1470,miR-1471,miR-1538,miR-1539,miR-103b,miR-1908-5p,miR-190 9-5p,miR-1909-3p,miR-1910-5p,miR-1912-3p,miR-1913,miR-1914-3p,miR-1915-3p,miR-103a-2-5p,miR-365a-5p,miR-196b-3p,miR-49b-3p, miR-2113,miR-1972,miR-1976,miR-2110,let-7a-2-3p,miR-151b,miR-76 2,miR-670-5p,miR-761,miR-764,miR-2115-5p,miR-2116- 3p,miR-548q,miR-2276-3p,miR-2277-3p,miR-2278,miR-711,mi R-2681-3p,miR-2682-5p,miR-2682-3p,miR-49c-3p,miR-2909,miR-31� 6,miR-3119,miR-3120-3p,miR-3122,miR-3124-5p,miR-3125,miR-3126-� p,miR-3127-5p,miR-3130-3p,miR-3130-5p,miR-3132,miR-31 33,miR-466,miR-3136-5p,miR-3137,miR-3138,miR-3141,miR-3144-5p,m iR-1273c,miR-3147,miR-3148,miR-3149,miR-3151-5p,m iR-3153,miR-3074-3p,miR-3154,miR-3155a,miR-3156-5p,miR-3157-�p, miR-3158-3p,miR-3160-3p,miR-3162-5p,miR-3163,miR-3165 ,miR-1260b,miR-3173-3p,miR-1193,miR-3176,miR-3177-3p,m iR-3178,miR-3179,miR-3180-3p,miR-3185,miR-3186-5p, miR-3186-3p,miR-3187-3p,miR-3188,miR-3189-3p,miR-320e,miR-3190- 5p,miR-3191-3p,miR-3192-5p,miR-3195,miR-3196,miR-3197,miR-3198, miR-3199,miR-3200-3p,miR-3202,miR-3126-3p,miR-4295,miR-4296,miR-4297,miR-4293,miR-4294,miR-4301,miR-4299,miR-4298,miR-430 0,miR-4304,miR-4303,miR-4305,miR-4306,miR-4307,miR-4308,miR-4311,miR-4, 312,miR-4313,miR-4316,miR-4314319,miR-4317,miR-4322,miR- 4321,miR-4323,miR-4324,miR-4256,miR-4257,miR-4258,miR-4259,miR- 4260,miR-4253,miR-4251,miR-4254,miR-4252,miR-4326,miR -4327,miR-4261,miR-4265,miR-4262,miR-2355-5p,miR-4268, miR-4269,miR-4271,miR-4276,miR-4274,miR-4279,miR-4278,miR-4280 ,miR-4285,miR-4283,miR-4284,miR-4286,miR-4288,miR-4292,miR-4289 ,miR-43290,miR-4329,miR-2277-5p,miR-3605-3p,miR-361 0,miR-3612,miR-3614-5p,miR-3615,miR-3616-3p,miR-3619-5p,miR-362 0-3p,miR-3621,miR-3622a-3p,miR-3622b-5p,miR-3646, miR-3648,miR-3649,miR-3650,miR-3651,miR-3652,miR-3654,miR-365��, miR-3659,miR-360,miR-361,miR-3663-5p,miR-3663-3p,miR-3665,mi R-3667-3p,miR-367-3p,miR-3675-3p,miR-3679-5p,miR-3 679-3p,miR-3682-3p,miR-3685,miR-3689a-3p,miR-3691-5p,miR-3692- 5p,miR-3713,miR-3714,miR-3714,miR-3689b-3p,miR-3689c,miR-3911,m iR-3917,miR-3918,miR-3919,miR-3150b-3p,miR-3922-3p,miR-3925-5p ,miR-676-3p,miR-3929,miR-3934-5p,miR-3935,miR-3936,miR-3937,miR-3940-3p,miR-3944-3p,miR-3945,miR-642b-3 p,miR-550b-3p,miR-1268b,miR-4420,miR-4421,miR-378g,miR-4425,mi R-4428,miR-4429,miR-4430,miR-4431,miR-4433a-3p,miR-4435,miR-44 36a,miR-4437,miR-4438,miR-4439,miR-4440,miR-4441,miR-4443,miR- 4444,miR-4445-3p,miR-4446-3p,miR-4447,miR-4448,miR-449,miR-44 50,miR-4451,miR-4453,miR-4454,miR-44556,miR-4458,miR-3 78h,miR-3135b,miR-4462,miR-4463,miR-4465,miR-4466,miR-4467,miR -4470,miR-4472,miR-4474-3p,miR-4475,miR-4476,miR-4478,miR-3689 d,miR-3689f,miR-4479,miR-3155b,miR-4483,miR-4484,miR- 4486,miR-4487,miR-4488,miR-4489,miR-4491,miR-4492,miR-4494,miR -4496,miR-4497,miR-4498,miR-499,miR-4502,miR-4505,miR-4506,mi R-2392,miR-4507,miR-4508,miR-4510,miR-4513,miR-4514,miR-4516,m iR-4518,miR-4520-3p,miR-4521,miR-1269b,miR-4522,miR-4523,miR-4 524a-3p,miR-4525,miR-4526,miR-4529-3p,miR-4530,miR-4531,miR-45 33,miR-4534,miR-378i,miR-4535,miR-1587,miR-4537,miR-4 539,miR-4540,miR-3120-5p,miR-3127-3p,miR-3129-3p,miR-3150a-5p,miR-3152-5p,miR-3074-5p,miR-3156-3p,miR-3158-5p,miR-3160-5p,mi R-3162-3p,miR-3173-5p,miR-3187-5p,miR-3189-5p,miR-3619-3p,miR-3 691-3p,miR-3150b-5p,miR-3922-5p,miR-3940-5p,miR-3944-5p,miR-44 23-5p,miR-446-5p,miR-4520-5p,miR-4529-5p,miR-3960,miR-3972,miR -463-3p,miR-4634,miR-4635,miR-4638-5p,miR-4640-5p ,miR-4640-3p,miR-4641,miR-4642,miR-46446-5p,miR-4646-3p ,miR-4647,miR-4648,miR-4649-3p,miR-4650-3p,miR-465 1,miR-4652-5p,miR-4653-5p,miR-4654,miR-4655-5p,miR- 4656,miR-4657,miR-4658,miR-460,miR-461-3p,miR-464-5p,miR-46 64-3p,miR-4665-5p,miR-4665-3p,miR-467-3p,miR-219b- 5p,miR-4669,miR-4672,miR-4673,miR-4674,miR-4676-5p,miR-4676-3p ,miR-4677-5p,miR-4681,miR-4682,miR-4684-5p,miR-4684-3p,miR-4685 -5p,miR-4685-3p,miR-4687-5p,miR-1343-3p,miR-4688,miR- 4689,miR-4690-5p,miR-4691-5p,miR-4692,miR-4695-5p,miR-4695-3p,m iR-4697-5p,miR-4697-3p,miR-4698,miR-4700-5p,miR-4700-3p,miR-47 01-5p,miR-4701-3p,miR-4706,miR-4707-5p,miR-4707-3p,miR-4708-5p,miR-4708-3p,miR-4709-5p,miR-4709-3p,miR-4711-3p,miR-4 713-5p,miR-4713-3p,miR-4714-5p,miR-4716-3p,miR-352 9-5p,miR-4717-5p,miR-4717-3p,miR-4718,miR-4720-5p,miR-4721,miR -4722-5p,miR-4722-3p,miR-4723-3p,miR-4724-5p,miR-4 725-5p,miR-4725-3p,miR-4726-5p,miR-4727-3p,miR-472 8-5p,miR-4728-3p,miR-4730,miR-4731-3p,miR-4732-5p, miR-4732-3p,miR-4734,miR-47364-5p,miR-3064-3p ,miR-4738-3p,miR-4740-5p,miR-4740-3p,miR-4743-5p,miR- 122b-3p,miR-4745-5p,miR-4746-3p,miR-4748,miR-4749- 5p,miR-4749-3p,miR-4750-5p,miR-4753-3p,mi R-371b-3p,miR-4754,miR-4755-3p,miR-4756-5p,miR-475 6-3p,miR-4758-5p,miR-4758-3p,miR-4763-5p,miR-4763-3p, miR-4764-5p,miR-4769-5p,miR-4769-3p,miR-4773,miR-4 776-5p,miR-4776-3p,miR-4778-5p,miR-4779,miR-4780,miR-4436b-5p, miR-4436b-3p,miR-4781-5p,miR-4783-3p,miR-4785,miR-246 7-3p,miR-4786-3p,miR-4787-5p,miR-4787-3p,miR-4788,miR-4793-3p,miR-4794,miR-4800-5p,miR-4800-3p,miR-4801,miR-480 4-3p,miR-642a-3p,miR-550a-3-5p,miR-4433a-5p,miR-4482-3p,miR-49 99-5p,miR-5000-5p,miR-5000-3p,miR-5001-3p,miR-5002 -5p,miR-5002-3p,miR-5003-3p,miR-5004-3p,miR-5006-5 p,miR-5006-3p,miR-5007-5p,miR-5009-3p,miR-5010-3p, miR-5087,miR-5088-5p,miR-5089-5p,miR-50903,miR-5187-5p ,miR-5187-3p,miR-5188,miR-5189-5p,miR-5190,miR-5192,miR-5193,m iR-5194,miR-5195-5p,miR-5196-5p,miR-5196-3p,miR-4524b-5p,miR-4 524b-3p,miR-5571-5p,miR-5571-3p,miR-5100,miR-5572,miR-664b-p ,miR-664b-3p,miR-5580-5p,miR-5581-5p,miR-5581-3p,m iR-5584-5p,miR-5584-3p,miR-5585-3p,miR-5587-3p,miR-548au-3p,mi R-5588-5p,miR-5588-3p,miR-5589-5p,miR-5684,miR-5681b, miR-5690,miR-5694,miR-5698,miR-5702,miR-5703,miR-5704,miR-5705 ,miR-5708,miR-197-5p,miR-204-3p,miR-211-3p,miR-345-3p,miR-584- 3p,miR-652-5p,miR-660-3p,miR-1185-2-3p,miR-766-5p,miR-873-3p,m iR-1285-5p,miR-1304-3p,miR-1247-3p,miR-1255b-2-3p,miR-1306-5p,miR-3184-3p,miR-3191-5p,miR-642b-5p,miR-365b-5p,miR-1185-1-3 p,miR-3190-3p,miR-98-3p,miR-216a-3p,miR-381-5p,miR-495-5p,miR-503-3p,miR-7, 58-5p,miR-939-3p,miR-1227-5p,miR-1229-5p,miR-1233-� p,miR-1236-5p,miR-1237-5p,miR-1238-5p,miR-1292-3p,miR-3617-3p, miR-3620-5p,miR-3927-5p,miR-3934-3p,miR-4632-5p,miR-4750-3p,mi R-5089-3p,miR-5739,miR-5787,miR-6068,miR-6069,miR-6071,miR-6072 ,miR-6074,miR-6075,miR-6076,miR-6077,miR-6080,miR-6081,miR-608 3,miR-6084,miR-6085,miR-6086,miR-6089,miR-6090,miR-6124,miR-612 5,miR-6126,miR-6127,miR-378j,miR-6129,miR-6130,miR-6131,miR-61 32,miR-6133,miR-6165,miR-6499-3p,miR-6500-3p,miR-65 01-5p,miR-6501-3p,miR-6503-5p,miR-6504-5p,miR-6504 -3p,miR-6505-3p,miR-6506-5p,miR-6507-3p,miR-6508-5p,miR-6509-5p ,miR-6509-3p,miR-6510-5p,miR-6511a-5p,miR-6511a-3p,miR-6512-3p ,miR-6513-3p,miR-6514-5p,miR-6515-5p,mi R-6515-3p,miR-6715a-3p,miR-6715b-5p,miR-6716-5p,mi R-6717-5p,miR-6511b-5p,miR-6511b-3p,miR-6718-5p,miR-6719-3p,miR -6721-5p,miR-6722-5p,miR-6722-3p,miR-6724-5p,miR-892c-5p,miR-8 92c-3p,let-7c-3p,miR-210-5p,miR-128-1-5p,miR-134-3p,miR-370-5p,miR-433-5p,miR-329-5p,miR-410-5p,miR-487a-5p,miR-489-5p,miR-49 4-5p,miR-504-3p,miR-487b-5p,miR-579-5p,miR-585-5p,mi R-605-3p,miR-619-5p,miR-656-5p,miR-68-5p,miR-1296-3p,miR-130� -5p,miR-1298-3p,miR-874-5p,miR-889-5p,miR-887-5p,miR-1250-3p,mi R-1251-3p,miR-1266-3p,miR-1288-5p,miR-1910-3p,miR- 3192-3p,miR-500b-3p,miR-3928-5p,miR-1343-5p,miR-5088-3p,miR-518 9-3p,miR-5699-5p,miR-6720-5p,miR-6726-3p,miR-6727- 5p,miR-6727-3p,miR-6728-3p,miR-6729-5p,miR-6729-3p, miR-6730-5p,miR-6730-3p,miR-6731-3p,miR-6732-5p,mi R-6732-3p,miR-6734-5p,miR-6735-3p,miR-6 736-3p,miR-6737-5p,miR-6737-3p,miR-6738-3p,miR-673 9-3p,miR-6740-5p,miR-6741-3p,miR-6741-3p,miR-6742-5 p,miR-6742-3p,miR-6743-3p,miR-6744-5p,miR-6744-3p, miR-6745,miR-6746-5p,miR-6747-3p,miR-67 48-5p,miR-6748-3p,miR-6749-3p,miR-6750-5p,miR-675�- 3p,miR-6751-3p,miR-6752-5p,miR-6752-3p,miR-6753-5p,miR-6753-3p,miR-6754-3p,miR-6755-5p,miR-6756-5p,mi R-6756-3p,miR-6757-3p,miR-6758-5p,miR-6759-5p,miR-6 759-3p,miR-6760-5p,miR-6760-3p,miR-6761-3p,miR-676 2-5p,miR-6762-3p,miR-6763-5p,miR-6763-3p,miR-6764-3p,miR-6765-5 p,miR-6766-5p,miR-6766-3p,miR-6767-5p,miR-6768-5p,miR-6769a-5p ,miR-6769a-3p,miR-6770-5p,miR-6770-3p,miR-6771-3p,miR-6772-5p,m iR-6772-3p,miR-6773-3p,miR-6774-3p,miR-6775-5p,miR -6775-3p,miR-6776-5p,miR-6777-3p,miR-67 78-5p,miR-6779-5p,miR-6779-3p,miR-6780a-5p,miR-678 0a-3p,miR-6781-5p,miR-6781-3p,miR-6782-5p,miR-6782-3p,miR-6783- 5p,miR-6783-3p,miR-6784-3p,miR-6785-3p,miR-6786-�p ,miR-6786-3p,miR-6787-5p,miR-6787-3p,miR-6788-5p,mi R-6789-3p,miR-6790-5p,miR-6790-3p,miR-6791-3p,miR- 6792-5p,miR-6792-3p,miR-6793-3p,miR-6794-5p,miR-679 4-3p,miR-6795-3p,miR-6796-5p,miR-6796-3p,miR-6797- 5p,miR-6797-3p,miR-6798-3p,miR-6799-5p,miR-6799-3p,miR-6800-5p,miR-6800-3p,miR-6801-3p,miR-6802-3p,mi R-6803-3p,miR-6804-5p,miR-6804-3p,miR-6805-5p,miR- 6805-3p,miR-6806-5p,miR-6807-5p,miR-6808-5p,miR-68 09-3p,miR-6810-5p,miR-6810-3p,miR-6812-3p,miR-6813- 5p,miR-6813-3p,miR-6814-3p,miR-6815-5p,miR-6815-3p ,miR-6816-5p,miR-6816-3p,miR-6817-5p,miR-6817-3p,miR-6819-5p,mi R-6819-3p,miR-6820-5p,miR-6820-3p,miR-6821-3p,miR- 6822-5p,miR-6822-3p,miR-6823-3p,miR-6824-5p,miR-682 4-3p,miR-6825-5p,miR-6825-3p,miR-6827-5p,miR-6827- 3p,miR-6828-5p,miR-6829-3p,miR-6830-5p,miR-6830-3p ,miR-6831-3p,miR-6831-3p,miR-6832-3p,miR-6833-5p,m iR-6833-3p,miR-6834-3p,miR-6780b-3p,mi R-6836-5p,miR-6837-5p,miR-6838-5p,miR-6839-5p,miR- 6840-5p,miR-6840-3p,miR-6841-3p,miR-6842-5p,miR-6842-3p,miR-684 3-3p,miR-6845-3p,miR-6846-5p,miR-6846-3p,miR-6847- 5p,miR-6847-3p,miR-6848-3p,miR-6849-3p,miR-6850-5p,miR-6851-3p,miR-6852-5p,miR-6852-3p,m iR-6853-5p,miR-6854-3p,miR-6855-5p,miR -6857-3p,miR-6858-5p,miR-6858-3p,miR-6859-5p,miR-6 859-3p,miR-6769b-5p,miR-6860,miR-6861-3p,miR-6862- 5p,miR-6862-3p,miR-6863,miR-6865-3p,miR-6867-5p,miR-6867-3p,mi R-6868-5p,miR-6868-3p,miR-6869-5p,miR-6870-3p,miR- 6871-5p,miR-6871-3p,miR-6872-3p,miR-6873-3p,miR-6874-5p,miR-68 75-5p,miR-6876-5p,miR-6876-3p,miR-6877-5p,miR-6877 -3p,miR-6878-3p,miR-6879-5p,miR-6879-3p,miR-6880-5p,miR-6880-3 p,miR-6881-3p,miR-6882-5p,miR-6882-3p,miR-6883-5p, miR-6883-3p,miR-6884-3p,miR-6885-3p,miR-6886-5p,mi R-6886-3p,miR-6887-3p,miR-6888-5p,miR-6889-5p,miR- 6889-3p,miR-6890-3p,miR-6891-3p,miR-6891-3p,miR-68 92-3p,miR-6893-3p,miR-6894-3p,miR-6894-3p,miR-6895 -5p,miR-6895-3p,miR-7106-5p,miR-7106-3p,miR-7107-5p,miR-7108-5 p,miR-7108-3p,miR-7109-5p,miR-7110-3p,miR-7111-5p,miR-711-3p,miR-7112-5p,miR-7113-3p,miR-71 14-5p,miR-7114-3p,miR-7151-5p,miR-7151-3p,miR-7152-5p,miR, -7152-3p,miR-7154-3p,miR-7155-3p,miR-7155-3p,miR-7 157-5p,miR-7157-3p,miR-7158-5p,miR-7160-5p,miR-7162-3p,miR-75� 5,miR-7702,miR-7843-5p,miR-4433b-3p,miR-1273h-5p, miR-1273h-3p,miR-6516-5p,miR-7846-3p,miR-7847-3p,m iR-7850-5p,miR-7851-3p,miR-7854-3p,miR-7855-5p,miR -8052,miR-8054,miR-8057,miR-8059,miR-8060,miR-8062,miR-8063,mi R-8064,miR-8069,miR-8070,miR-8071,miR-8072,miR-8073,miR-8074,m iR-8075,miR-8077,miR-8079,miR-8080,miR-8082,miR-8083, miR-8085,miR-8086,miR-8087,miR-80889,miR-1199-3p,miR-7 975,miR-7976,miR-7978,miR-1249-5p,miR-485-5p,miR-848 5,miR-103a-1-5p,miR-196a-1-3p,miR-135a-2-3p,miR-375-5p,miR-526 a-3p,miR-9718,miR-9898,miR-1843,miR-9986,miR-10226,mi R-10392-5p,miR-10394-3p,miR-10395-5p,miR-10395-3p ,miR-10396a-3p,miR-10398-5p,miR-10398-3p,miR-104 00-3p,miR-10401-5p,miR-10401-3p,miR-10396b-3p,mi R-10522-5p,miR-10523-5p,miR-10526-3p,miR-10527-5p,miR-1181-5p,miR-11181-3p, miR-11399, miR-11400, miR-11401, miR-3059-5p, miR-3059-3p, miR -3085-5p, miR-3085-3p, miR-6529-5p, miR-12114, miR-12115, miR-12116, miR-1211 7, miR-12118, miR-12119, miR-12120, miR-12121, miR-12122, miR-12124, miR-12125, miR-12126, miR-12127, miR-12128, miR-12131, and miR-12136 (Uro); The urine is from a subject having or suspected of having lung cancer. method.

29. The method according to any one of claims 25 to 28, comprising detecting five or more types of microRNA.

30. The method of any one of claims 25 to 28, comprising detecting 10 or more, 15 or more, or 20 or more microRNAs.

31. The method according to any one of claims 25 to 28, wherein the microRNA is a microRNA that further satisfies the condition in Tables 4-1 to 4-15 that its expression is increased in lung cancer patients {in each table, the microRNA may be one or more types, two or more types, three or more types, four or more types, five or more types, ten or more types, fifteen or more types, or twenty or more types of microRNA}.

32. The method according to any one of claims 25 to 28, wherein the microRNA is a microRNA that further satisfies the condition in Tables 4-1 to 4-15 that its expression is reduced in lung cancer patients {in each table, the microRNA may be one or more types, two or more types, three or more types, four or more types, five or more types, ten or more types, fifteen or more types, or twenty or more types of microRNA}.

33. 1. A method for predicting the likelihood of a subject having early stage lung cancer in a subject having or suspected of having lung cancer, comprising:

26. The method according to claim 25, wherein the microRNA further satisfies the condition in Tables 4-1 to 4-15 that its expression is increased in lung cancer patients {in each table, the microRNA may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; the presence of a microRNA with expression greater than a first threshold indicates a likelihood that the subject from which the urine was derived has early stage lung cancer; method.

34. 1. A method for predicting the likelihood of a subject having early stage lung cancer in a subject having or suspected of having lung cancer, comprising:

26. The method according to claim 25, wherein the microRNA further satisfies the condition in Tables 4-1 to 4-15 that expression is reduced in cancer patients {in each table, the microRNA may be 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 10 or more, 15 or more, or 20 or more microRNAs}; the presence of a microRNA with expression below a first threshold indicates a likelihood that the subject from which the urine was derived has lung cancer; method.

35. The method of claim 33, wherein the number of microRNAs showing expression higher than the first threshold is five or more.

36. The method of claim 33, wherein the number of microRNAs showing expression higher than the first threshold is 10 or more, 15 or more, or 20 or more.

37. The method of claim 34, wherein the number of microRNAs whose expression is lower than the second threshold is five or more.

38. The method of claim 34, wherein the number of microRNAs whose expression is lower than the second threshold is 10 or more, 15 or more, or 20 or more.

39. The method according to any one of claims 1 to 38, which is an in vitro method.

40. The method of any one of claims 10 to 39, wherein the nanowires are nanowires having a metal oxide surface.

41. 41. The method of claim 40, wherein the nanowires are nanowires having a zinc oxide surface.

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