Anhydrous composition that stabilizes poorly soluble substance and provides excellent feeling of use

Abstract

To provide an anhydrous composition.SOLUTION: A composition according to one aspect of the present disclosure includes a fatty acid alcohol, an emollient, a wax, and a poorly soluble substance, has a viscosity of 300 cSt or more at 30°C, can stabilize poorly soluble substances that provide effects to the human body to increase the moisture retention in the skin or hair, can provide softness and shine to the hair upon use, and can exhibit excellent feeling of use without stickiness or residual feeling on the hands.SELECTED DRAWING: Figure 1

Description

Technical Field

[0001] The present disclosure relates to an anhydrous composition (anhydrous pharmaceutical composition) that stabilizes poorly soluble substances and has excellent usability.

Background Art

[0002] Ceramide is a typical component of the skin and hair, and can exhibit a unique skin barrier function by preventing the loss of moisture from the human body and blocking the inflow of harmful substances from the outside. However, ceramide has a fatal drawback in that it aggregates in cosmetic formulations or separates and precipitates as needle-like crystals. Thus, although it can exhibit excellent efficacy against the human body such as the skin and hair, it is difficult to dissolve and / or stabilize when applied to cosmetic formulations and the like, and there are many poorly soluble substances that are difficult to actually deliver efficacy to the human body. Therefore, there is an urgent need to develop a composition that can stably dissolve and / or disperse poorly soluble substances in cosmetic formulations and the like.

[0003] On the other hand, anhydrous compositions such as oily cosmetics (for example, hair oil) can give softness and gloss by immediately forming a coating film on the skin and hair. However, many of them only have a temporary effect, and in addition, due to the slippery feeling peculiar to oil remaining on the hands, it may give users an uncomfortable feeling. Therefore, there is a demand for the development of a composition that does not leave a residue on the hands during use, gives a refreshing feeling of use, is effectively absorbed by the skin and hair, and can give softness and gloss to the skin and hair.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] One aspect of the present disclosure aims to provide an anhydrous composition that stabilizes poorly soluble substances and has excellent usability.

Means for Solving the Problems

[0006] The anhydrous composition according to one aspect of the present disclosure includes a fatty alcohol, an emollient, a wax, and a poorly soluble substance, and has a viscosity at 30 °C of 300 cSt or more.

Effects of the Invention

[0007] The anhydrous composition according to one aspect of the present disclosure can stabilize a poorly soluble substance effective for the human body in the formulation.

[0008] In the present disclosure, the anhydrous composition according to one aspect can stabilize a poorly soluble substance effective for the human body, enhance the transmission efficiency to the body, and as a result, can enhance the moisturizing power in the skin and hair, provide softness and gloss to the skin and hair, and provide an excellent usability without stickiness or a residual feeling.

Brief Description of the Drawings

[0009]

Figure 1

Figure 2

Figure 3

Mode for Carrying Out the Invention

[0010] The various examples and terms used herein are not intended to limit the technology described herein to specific examples, but should be understood to include various modifications, equivalents, or alternatives of such examples.

[0011] The inventors have developed an anhydrous composition that can effectively dissolve and stabilize poorly soluble substances, exhibit efficacy in the human body such as on the skin and hair, and at the same time has little stickiness and excellent usability.

[0012] One aspect of the present disclosure provides an anhydrous composition comprising a fatty alcohol, an emollient, and a wax. One aspect of the present disclosure provides an anhydrous composition comprising a fatty alcohol, an emollient, and a wax, and having a viscosity at 30 °C of 300 cSt or more.

[0013] According to one implementation example, the anhydrous composition may have a viscosity at 30 °C of 300 cSt or more, 350 cSt or more, 400 cSt or more, 450 cSt or more, 500 cSt or more, 550 cSt or more, 600 cSt or more, 650 cSt or more, 700 cSt or more, 750 cSt or more, 800 cSt or more, 850 cSt or more, 900 cSt or more, 950 cSt or more, 1000 cSt or more, and may be 10000 cSt or less, 11000 cSt or less, 12000 cSt or less, 13000 cSt or less, 14000 cSt or less, 15000 cSt or less, 20000 cSt or less, 30000 cSt or less, 40000 cSt or less, 50000 cSt or less, or a range combining them (for example, 300 to 15000 cSt), but is not limited thereto. 30 °C may be the temperature serving as the viscosity measurement standard. cSt may be the unit for measuring kinematic viscosity.

[0014] According to an embodiment of the present disclosure, when the viscosity of the anhydrous composition at 30 °C is equal to or higher than the predetermined viscosity, poorly soluble substances (e.g., ceramides, etc.) can be dissolved in the composition and uniformly dispersed, and the preparation does not separate and has excellent stability. On the other hand, when the viscosity of the anhydrous composition at 30 °C is lower than the predetermined viscosity, poorly soluble substances such as ceramides do not dissolve in the composition and precipitate, or the preparation separates, etc., and the preparation stability is poor. The composition according to one aspect of the present disclosure has poorly soluble substances uniformly dispersed and stabilized, and when applied to the human body such as the skin and hair, the efficacy (e.g., moisturizing power, etc.) of the poorly soluble substances can be effectively exerted.

[0015] According to one implementation example, the anhydrous composition includes a fatty alcohol, an emollient, and a wax, and by having the aforementioned viscosity range, it can effectively dissolve poorly soluble substances and stabilize them in the preparation.

[0016] According to one implementation example, the anhydrous composition may further include a poorly soluble substance.

[0017] One aspect of the present disclosure provides an anhydrous composition including a fatty alcohol, an emollient, a wax, and a poorly soluble substance, and having a viscosity at 30 °C of 300 cSt or higher.

[0018] According to one implementation example, the anhydrous composition may have a viscosity at 30°C of 300 cSt or more, 350 cSt or more, 400 cSt or more, 450 cSt or more, 500 cSt or more, 550 cSt or more, 600 cSt or more, 650 cSt or more, 700 cSt or more, 750 cSt or more, 800 cSt or more, 850 cSt or more, 900 cSt or more, 950 cSt or more, 1000 cSt or more, and may be 10000 cSt or less, 11000 cSt or less, 12000 cSt or less, 13000 cSt or less, 14000 cSt or less, 15000 cSt or less, 20000 cSt or less, 30000 cSt or less, 40000 cSt or less, 50000 cSt or less, or a range combining them (for example, 300 to 15000 cSt), but is not limited thereto. 30°C may be the temperature serving as the viscosity measurement standard. cSt may be the unit for measuring kinematic viscosity.

[0019] According to one implementation example, the fatty acid alcohol may be a C9-27 fatty acid alcohol, a C10-26 fatty acid alcohol, a C11-25 fatty acid alcohol, a C12-24 fatty acid alcohol, a C13-23 fatty acid alcohol, or a C14-22 fatty acid alcohol, but is not limited thereto. According to one implementation example, the fatty acid alcohol may be a saturated fatty acid alcohol. For example, the fatty acid alcohol is a C14-22 saturated fatty acid alcohol. According to one implementation example, the fatty acid alcohol may be at least one selected from the group consisting of myristyl alcohol, cetyl alcohol, stearyl alcohol, and behenyl alcohol.

[0020] According to one implementation example, the fatty alcohol may be contained in the composition in an amount of 0.01 to 10% by weight, but is not limited thereto. For example, the fatty alcohol may be contained in the composition in an amount of 0.01% by weight or more, 0.05% by weight or more, 0.1% by weight or more, 0.5% by weight or more, 1% by weight or more, 1.5% by weight or more, 2% by weight or more, 2.5% by weight or more, 3% by weight or more, 3.5% by weight or more, 4% by weight or more, 4.5% by weight or more, 5% by weight or more, 5.5% by weight or more, 6% by weight or more, 6.5% by weight or more, 7% by weight or more, 7.5% by weight or more, 8% by weight or more, 8.5% by weight or more, 9% by weight or more, 9.5% by weight or more, 10% by weight or more, and may be contained in an amount of 0.01% by weight or less, 0.05% by weight or less, 0.1% by weight or less, 0.5% by weight or less, 1% by weight or less, 1.5% by weight or less, 2% by weight or less, 2.5% by weight or less, 3% by weight or less, 3.5% by weight or less, 4% by weight or less, 4.5% by weight or less, 5% by weight or less, 5.5% by weight or less, 6% by weight or less, 6.5% by weight or less, 7% by weight or less, 7.5% by weight or less, 8% by weight or less, 8.5% by weight or less, 9% by weight or less, 9.5% by weight or less, 10% by weight or less, or in a combination thereof.

[0021] "Emollient" is an oil-soluble oily substance for enhancing luster, and can soften the touch of the surface of the skin or hair and form a moisturizing film.

[0022] According to one implementation example, the emollient may be at least one selected from the group consisting of ester-based emollients, triglyceride-based emollients, and hydrocarbon-based emollients.

[0023] According to one implementation example, the ester-based emollient may be an ester of a carboxylic acid and a C3-C20 alcohol. According to one implementation example, the ester-based emollient may be an ester of a C3-C14 carboxylic acid and a C3-C20 alcohol, an ester of a C3-C14 carboxylic acid and a C9-C20 alcohol, an ester of a C4-C13 carboxylic acid and a C10-C19 alcohol, an ester of a C5-C12 carboxylic acid and a C10-C18 alcohol, an ester of a C6-C11 carboxylic acid and a C11-C17 alcohol, or an ester of a C7-C10 carboxylic acid and a C12-C16 alcohol, but is not limited thereto. According to one implementation example, the ester-based emollient may be at least one selected from the group consisting of cetyl ethylhexanoate, C12-15 alkyl benzoate, and isopropyl myristate.

[0024] According to one implementation example, the triglyceride-based emollient may be an ester of a C3-C22 carboxylic acid and glycerol, an ester of a C4-C14 carboxylic acid and glycerol, an ester of a C5-C13 carboxylic acid and glycerol, an ester of a C6-C12 carboxylic acid and glycerol, an ester of a C7-C11 carboxylic acid and glycerol, or an ester of a C8-C10 carboxylic acid and glycerol, but is not limited thereto. According to one implementation example, the triglyceride-based emollient may be at least one selected from the group consisting of caprylic / capric triglyceride, camellia oil, and abyssinian oil.

[0025] According to one implementation example, the hydrocarbon-based emollient may be at least one selected from the group consisting of hydrogenated polyisobutene, squalane, squalene, and polybutene.

[0026] According to one implementation example, the emollient may be contained in the composition in an amount of 0.1 to 15% by weight, but is not limited thereto. For example, the emollient may be contained in the composition in an amount of 0.1% by weight or more, 0.5% by weight or more, 1% by weight or more, 2% by weight or more, 3% by weight or more, 4% by weight or more, 5% by weight or more, 6% by weight or more, 7% by weight or more, 8% by weight or more, 9% by weight or more, 10% by weight or more, 11% by weight or more, 12% by weight or more, 13% by weight or more, 14% by weight or more, 15% by weight or more, and may also be contained in an amount of 0.1% by weight or less, 0.5% by weight or less, 1% by weight or less, 2% by weight or less, 3% by weight or less, 4% by weight or less, 5% by weight or less, 6% by weight or less, 7% by weight or less, 8% by weight or less, 9% by weight or less, 10% by weight or less, 11% by weight or less, 12% by weight or less, 13% by weight or less, 14% by weight or less, 15% by weight or less, or a combination thereof.

[0027] According to one implementation example, the wax may be a natural wax, but is not limited thereto. According to one implementation example, the wax may be at least one selected from the group consisting of JOJOBA ESTERS, MANGIFERA INDICA (MANGO) SEED BUTTER, ASTROCARYUM MURUMURU SEED BUTTER, and HYDROGENATED VEGETABLE OIL, but is not limited thereto.

[0028] According to one implementation example, the melting point of the wax may be 25 to 75 °C. According to one implementation example, the melting point of the wax may be 25 °C or higher, 26 °C or higher, 27 °C or higher, 28 °C or higher, 29 °C or higher, 30 °C or higher, 31 °C or higher, 32 °C or higher, 33 °C or higher, 34 °C or higher, 35 °C or higher, 36 °C or higher, 37 °C or higher, 38 °C or higher, 39 °C or higher, 40 °C or higher, 41 °C or higher, 42 °C or higher, 43 °C or higher, 44 °C or higher, 45 °C or higher, 46 °C or higher, 47 °C or higher, 48 °C or higher, 49 °C or higher, 50 °C or higher, 51 °C or higher, 52 °C or higher, 53 °C or higher, 54 °C or higher, 55 °C or higher, 56 °C or higher, 57 °C or higher, 58 °C or higher, 59 °C or higher, 60 °C or higher, 61 °C or higher, 62 °C or higher, 63 °C or higher, 64 °C or higher, 65 °C or higher, 66 °C or higher, 67 °C or higher, 68 °C or higher, 69 °C or higher, 70 °C or higher, 71 °C or higher, 72 °C or higher, 73 °C or higher, 74 °C or higher, 75 °C or higher, or may be 25 °C or lower, 26 °C or lower, 27 °C or lower, 28 °C or lower, 29 °C or lower, 30 °C or lower, 31 °C or lower, 32 °C or lower, 33 °C or lower, 34 °C or lower, 35 °C or lower, 36 °C or lower, 37 °C or lower, 38 °C or lower, 39 °C or lower, 40 °C or lower, 41 °C or lower, 42 °C or lower, 43 °C or lower, 44 °C or lower, 45 °C or lower, 46 °C or lower, 47 °C or lower, 48 °C or lower, 49 °C or lower, 50 °C or lower, 51 °C or lower, 52 °C or lower, 53 °C or lower, 54 °C or lower, 55 °C or lower, 56 °C or lower, 57 °C or lower, 58 °C or lower, 59 °C or lower, 60 °C or lower, 61 °C or lower, 62 °C or lower, 63 °C or lower, 64 °C or lower, 65 °C or lower, 66 °C or lower, 67 °C or lower, 68 °C or lower, 69 °C or lower, 70 °C or lower, 71 °C or lower, 72 °C or lower, 73 °C or lower, 74 °C or lower, 75 °C or lower, or a combination thereof, but is not limited thereto.

[0029] According to one implementation example, the wax may be contained in the composition in an amount of 0.01 to 10% by weight, but is not limited thereto. For example, the wax may be contained in the composition in an amount of 0.01% by weight or more, 0.05% by weight or more, 0.1% by weight or more, 0.5% by weight or more, 1% by weight or more, 1.5% by weight or more, 2% by weight or more, 2.5% by weight or more, 3% by weight or more, 3.5% by weight or more, 4% by weight or more, 4.5% by weight or more, 5% by weight or more, 5.5% by weight or more, 6% by weight or more, 6.5% by weight or more, 7% by weight or more, 7.5% by weight or more, 8% by weight or more, 8.5% by weight or more, 9% by weight or more, 9.5% by weight or more, 10% by weight or more, or may be contained in an amount of 0.01% by weight or less, 0.05% by weight or less, 0.1% by weight or less, 0.5% by weight or less, 1% by weight or less, 1.5% by weight or less, 2% by weight or less, 2.5% by weight or less, 3% by weight or less, 3.5% by weight or less, 4% by weight or less, 4.5% by weight or less, 5% by weight or less, 5.5% by weight or less, 6% by weight or less, 6.5% by weight or less, 7% by weight or less, 7.5% by weight or less, 8% by weight or less, 8.5% by weight or less, 9% by weight or less, 9.5% by weight or less, 10% by weight or less, or in a combination thereof.

[0030] "Poorly soluble substance" means a substance that is not sufficiently soluble in water or oil and does not dissolve sufficiently, so that it easily precipitates from the preparation and exists unstably, and means a component that can be used in a composition for the purpose of imparting useful effects to the skin and / or hair, such as improvement of wrinkles, whitening, and moisturization of the skin.

[0031] The composition according to one aspect of the present disclosure includes a fatty alcohol, an emollient, and a wax, and by having a viscosity within a predetermined range, it can stably dissolve a poorly soluble substance and exhibit useful effects on the skin or hair.

[0032] According to one implementation example, the poorly soluble substance is a poorly soluble physiologically active substance, for example, it may be at least one selected from the group consisting of ceramide, madecassoside, hyaluronic acid, retinol, retinoid, coenzyme Q-10, ursolic acid, oleanolic acid, lipoic acid, protein, and water-soluble substances, but is not limited thereto.

[0033] According to one implementation example, ceramide is a molecule in which a fatty acid is bound to a sphingoid base. At this time, the sphingoid base may be at least one of sphingosine, dihydroxysphingosine, phytosphingosine, and 6-hydroxysphingosine, and the fatty acid may be at least one of natural fatty acids, alpha-hydroxy fatty acids, ester-bonded omega-hydroxy fatty acids, omega-hydroxy fatty acids, and 1-O-acrylamide. For example, ceramide may be at least one selected from phytosphingosine ceramide, sphingosine ceramide, dihydrosphingosine ceramide, and 6-hydroxysphingosine ceramide, but is not limited thereto. For example, ceramide may be at least one selected from ceramide NS, ceramide AS, ceramide EOS, ceramide NDS, ceramide ADS, ceramide EODS, ceramide NP, ceramide AP, ceramide EOP, ceramide NH, ceramide AH, and ceramide EOH.

[0034] According to one implementation example, the poorly soluble substance may be at least one selected from the group consisting of ceramide NS, ceramide AS, ceramide EOS, ceramide NDS, ceramide ADS, ceramide EODS, ceramide NP, ceramide AP, ceramide EOP, ceramide NH, ceramide AH, ceramide EOH, madecassoside, hyaluronic acid, retinol, retinoid, coenzyme Q-10, ursolic acid, oleanolic acid, lipoic acid, protein, and water-soluble substances, but is not limited thereto.

[0035] According to one implementation example, the poorly soluble substance may be contained in the composition in an amount of 0.1 to 1.5% by weight, but is not limited thereto. For example, the poorly soluble substance may be contained in the composition in an amount of 0.1% by weight or more, 0.2% by weight or more, 0.3% by weight or more, 0.4% by weight or more, 0.5% by weight or more, 0.6% by weight or more, 0.7% by weight or more, 0.8% by weight or more, 0.9% by weight or more, 1% by weight or more, 1.1% by weight or more, 1.2% by weight or more, 1.3% by weight or more, 1.4% by weight or more, 1.5% by weight or more, and may also be contained in an amount of 0.1% by weight or less, 0.2% by weight or less, 0.3% by weight or less, 0.4% by weight or less, 0.5% by weight or less, 0.6% by weight or less, 0.7% by weight or less, 0.8% by weight or less, 0.9% by weight or less, 1% by weight or less, 1.1% by weight or less, 1.2% by weight or less, 1.3% by weight or less, 1.4% by weight or less, 1.5% by weight or less, or in a range combining them.

[0036] According to one implementation example, the anhydrous composition may contain at least one selected from the group consisting of dimethicone, dimethiconol, cyclomethicone, and oil as a base. The oil may be cetyl ethylhexanoate, C12-15 alkyl benzoate, C9-12 alkane, but is not limited thereto.

[0037] In the present disclosure, "base" means a component that forms the basic matrix of the composition. The base plays a role in stably dissolving or dispersing other active ingredients and may affect the viscosity, feel in use, and stability of the composition.

[0038] The anhydrous composition according to one aspect of the present disclosure may further include, but is not limited to, at least one of dimethicone, dimethiconol, and oil. Dimethicone, dimethiconol, and / or oil may be components included in the base of the anhydrous composition according to one aspect of the present disclosure. According to one implementation example, the viscosity of the composition of the present disclosure may be adjusted by dimethicone and / or dimethiconol.

[0039] According to one implementation example, the fatty alcohol, emollient, and wax may form particles in the anhydrous composition. According to one aspect of the present disclosure, the fatty alcohol, emollient, and wax may be present in particulate form in the anhydrous composition. The particles may be solid lipid particles. The anhydrous composition according to one aspect of the present disclosure includes particles containing a fatty alcohol, an emollient, and a wax, and a poorly soluble substance, and may have a viscosity of 300 cSt or more at 30°C.

[0040] According to one implementation example, the anhydrous composition may not contain a surfactant. According to one implementation example, the anhydrous composition of the present disclosure can effectively dissolve and / or disperse a poorly soluble substance in an anhydrous formulation without a surfactant and can stably form a formulation.

[0041] According to one implementation example, the anhydrous formulation may be an oil formulation, specifically an anhydrous oil formulation.

[0042] In one implementation example, the composition may be a cosmetic composition, a food composition, an oral composition, a non-therapeutic composition, a non-therapeutic oral composition, a pharmaceutical composition, or a topical composition. For example, the composition is a cosmetic composition or a topical composition.

[0043] In one implementation example, the composition may further include additives such as a preservative, a thickener, a viscosity modifier, a stabilizer, a pearlescent agent, a sequestering agent, a cationic surfactant, a pH adjuster, a fragrance, and a dye, which can be easily purchased and used commercially.

[0044] The anhydrous composition according to one aspect of the present disclosure may be for skin, fingernails, toenails, or hair.

[0045] According to one implementation example, the anhydrous composition may be at least one of a hair serum, a hair oil, a hair essence, and a hair cream, but is not limited thereto. According to one implementation example, the anhydrous composition may be at least one selected from the group consisting of a lotion, a lotion, a cream, a beauty liquid, a hand cream, a mist, and an oil, but is not limited thereto.

[0046] The anhydrous composition according to one aspect of the present disclosure may be for promoting body moisturization. In one implementation example, the body further includes at least one selected from the group consisting of hair (e.g., scalp hair, eyelashes, eyebrows), skin (e.g., elbows, cuticles), fingernails, and toenails, but is not limited thereto.

[0047] The anhydrous composition according to one aspect of the present disclosure stabilizes a poorly soluble substance effective for the human body, effectively transmits the poorly soluble substance, and can enhance the moisturizing effect or moisturizing persistence in the body (e.g., skin, hair, fingernails, toenails), and at the same time, can exhibit an excellent feeling in use.

[0048] The anhydrous composition according to one aspect of the present disclosure stabilizes a poorly soluble substance and can enhance the moisturizing effect or moisturizing persistence in the body (e.g., skin, hair, fingernails, toenails).

[0049] The anhydrous composition according to one aspect of the present disclosure can provide softness and / or gloss to the body (e.g., skin, hair, fingernails, toenails) during use.

[0050] The anhydrous composition according to one aspect of the present disclosure can exhibit an excellent feeling in use without stickiness or a residue feeling on the hands during use.

[0051] The anhydrous composition according to one aspect of the present disclosure has no residue feeling on the hand during use and can be absorbed by the body (e.g., skin, hair, fingernails, toenails).

[0052] In one example, the anhydrous composition (e.g., high-viscosity oil formulation) according to one aspect of the present disclosure effectively stabilizes poorly soluble substances (e.g., ceramides) and has excellent formulation stability compared to the compositions of other formulations (e.g., low-viscosity oil formulations, low-viscosity emulsion formulations). Also, the anhydrous composition (e.g., high-viscosity oil formulation) according to one aspect of the present disclosure is excellent in the delivery efficiency of poorly soluble substances (e.g., ceramides) into the hair (e.g., the cuticle layer of the hair) compared to the compositions of other formulations (e.g., low-viscosity oil formulations, low-viscosity emulsion formulations).

[0053] One aspect of the present disclosure provides a method for promoting moisturization of the body, comprising the step of applying the aforementioned anhydrous composition to a subject. One aspect of the present disclosure provides a method for promoting moisturization of the body, comprising the step of applying the aforementioned anhydrous composition to the body of a subject. The body further includes at least one selected from the group consisting of, but not limited to, hair (e.g., scalp hair, eyelashes, eyebrows), skin (e.g., elbows, cuticles), fingernails, and toenails.

[0054] Also, one aspect of the present disclosure provides a method for promoting moisturization of hair, skin, fingernails or toenails, comprising the step of applying the aforementioned anhydrous composition to a subject.

[0055] In one implementation example, the subject may be an animal including a mammal (e.g., a human), but is not limited thereto.

[0056] In the present disclosure, the application may be oral administration, transdermal administration, subcutaneous administration, intravenous administration, intraperitoneal administration, intramuscular administration, or topical application, but is not limited thereto, and preferably, the application may include applying the aforementioned anhydrous composition to the hair.

[0057] In one implementation example, the daily dosage of the anhydrous composition may be 0.0001 to 10,000 mg / kg, but is not limited thereto. In one implementation example, the anhydrous composition may be applied once a day or divided into several times a day. However, it should be understood that the dosage of the anhydrous composition is determined in consideration of various relevant factors such as the route of administration, the age, gender, and body weight of the subject, and thus, the above dosage is not intended to limit the scope of the present invention in any way.

[0058] In the present disclosure, the term "hair" means any type of hair growing on an individual (including, for example, mammals). For example, in the present disclosure, the hair may include at least one selected from the group consisting of scalp hair, eyebrows, and eyelashes, but is not limited thereto.

[0059] One aspect of the present disclosure provides a use for promoting body moisturization of the anhydrous composition described above.

[0060] One aspect of the present disclosure provides a use for preparing a composition for promoting body moisturization of the anhydrous composition described above.

[0061] In one implementation example, the body further includes at least one selected from the group consisting of hair (e.g., scalp hair, eyelashes, eyebrows), skin (e.g., elbows, cuticles), fingernails, and toenails, but is not limited thereto.

[0062] In one implementation example, the composition for promoting body moisturization may be a cosmetic composition, a food composition, an oral composition, a non-therapeutic composition, a non-therapeutic oral composition, a pharmaceutical composition, or a topical composition.

[0063] Hereinafter, in order to specifically describe the present invention, examples will be given and described in detail. The following examples are provided to assist in understanding the present invention, and the scope and range of the present invention are not limited thereby.

[0064] 1. Preparation of anhydrous composition Hair oils of Examples 1 to 7 and Comparative Examples 1 to 5 were produced with the compositions shown in Table 1 below. Specifically, emollients, fatty alcohols, waxes, and / or poorly soluble substances were mixed based on them, and stirred to produce oils. The bases of Examples 1 to 7 and Comparative Examples 2 to 5 contain dimethicone, dimethiconol, and oil, and the base of Comparative Example 1 contains low-viscosity silicone oil (linear dimethicone (0.65 to 100 cs)) and oil.

[0065]

Table 1

[0066] The viscosities of the examples and comparative examples were measured using product test method No. 213 / 30. Specifically, 100 g of each composition of the examples and comparative examples was placed in a viscosity bottle, and then the viscosity of the content was measured using a rotational viscometer at 30 °C, 12 rpm, and for 2 minutes with a spindle for 3 times. When the viscosity was 10,000 or more, a spindle for 4 times was used.

[0067] 2. Evaluation of dissolution and stability of poorly soluble substances in the formulation In the compositions of the examples and comparative examples, it was visually confirmed whether the poorly soluble substances were effectively dissolved and dispersed. Specifically, the compositions of the examples and comparative examples were stored in a 30 °C chamber under constant temperature / humid conditions for 24 hours. As a result, in Comparative Example 1 where the viscosity measured at 30 °C was less than 300 cSt, the poorly soluble substances were not properly dissolved and settled. On the other hand, in the examples where the viscosity measured at 30 °C was 300 cSt or more, the poorly soluble substances were uniformly dispersed in the formulation without settling (see Figure 1).

[0068] In addition, the stability of the examples and comparative examples was analyzed using a LumiSizer, which is an apparatus for analyzing the dispersion stability and particle size distribution of substances under centrifugal force. First, the stabilization time of the temperature and humidity environment was ensured so that the equipment reached a controlled environment with a set temperature of 40 °C and a humidity of 50%. After ensuring the equipment settings under the conditions of a temperature of 40 °C and a humidity of 50%, the physical stability of the formulation was measured on a 3-hour cycle basis. As a result of the analysis, in the examples where the viscosity measured at 30 °C was 300 cSt or more, no phase separation or precipitation was observed, indicating excellent dispersion stability (Figure 2, the four test tubes from the right). On the other hand, in the comparative examples (Comparative Example 3: excluding wax, Comparative Example 4: excluding fatty alcohol) in which some of the components for stabilizing the poorly soluble substance were removed, the upper and lower layers were separated, and it was confirmed that the dispersion stability was poor (Figure 2, the two test tubes from the left). Figure 2 is a photograph of the samples after LumiSizer analysis, and from the left are Comparative Example 3, Comparative Example 4, Example 4, Example 5, Example 6, and Example 7 in order.

[0069] 3. Evaluation of usability and persistence of moisturizing effect (1) Evaluation of usability The usability of Examples 1 to 7 and Comparative Examples 2 to 5 was evaluated for a panel consisting of 20 female subjects aged 20 to 26 years.

[0070] The evaluation of usability was carried out after using the compositions of the examples and comparative examples once a day for two weeks each. The evaluation was conducted in a way that the subjects answered using a 9-point scale (the higher the score, the better). Specifically, for "softness of hair", a high score was given when the hair felt soft during use and the usability was good, and for "residual feeling on hands during use", a high score was given when the residual feeling on hands during use was small and it felt refreshing. Comparative Example 1 was excluded from this evaluation because the poorly soluble substance did not dissolve well, precipitated, and had poor formulation stability.

[0071] The average values of the usability evaluation scores of the 20 subjects are shown in Table 2 below. In the usability evaluation results in Table 2, X indicates that the quality is poor (1 - 3 points), △ indicates that the quality is ordinary (4 - 6 points), and O indicates that the quality is excellent (7 - 9 points).

[0072] (2) Evaluation of the Persistence of Moisturizing Effect The persistence of the moisturizing effect of Examples 1 to 7 and Comparative Examples 2 to 5 was evaluated.

[0073] Specifically, the contents were pumped twice onto towel-dried hair after shampooing, evenly applied, and the moisture content was measured. The hair used in the test was 60 bundles of black hair bundles (dyed once) with a hair moisture retention (infrared moisture meter FD-660) and 60 bundles of hair moisture retention (Epsilon E100). The moisturizing power before use, after one use, 8 hours after use, and 24 hours after use was confirmed.

[0074] As a result, Examples 1 to 7, which stably contained ceramide in the formulation, had a hair moisturizing persistence effect. On the other hand, Comparative Example 2, which did not contain ceramide, had no hair moisturizing effect. When the increase in water content after 24 hours compared to immediately after use was 10% or less, it was designated as X, and when it was more than 10%, it was designated as O. In Example 1, the water content increased by 42% after 24 hours compared to immediately after use.

[0075]

Table 2

[0076] As shown in Table 2, Comparative Examples 3 to 5, which did not contain any one of fatty acid alcohol, emollient, and wax, showed poor usability such as a residue feeling or stickiness on the hand during use, or poor softness of the hair after use. Comparative Example 2, which did not contain ceramide, a poorly soluble substance, had a poor moisturizing effect on the hair. Examples 1 to 7 showed an excellent moisturizing effect on the hair by stably dissolving / dispersing the poorly soluble substance, and at the same time had excellent usability and were soft when applied to the hair.

[0077] 4. Evaluation of ceramide residue amount in hair for each formulation The residual amount of ceramide in the hair of a high-viscosity oil formulation containing ceramide and a low-viscosity emulsion formulation was comparatively evaluated.

[0078] First, a low-viscosity emulsified formulation containing ceramide and a high-viscosity oil formulation according to one aspect of the present disclosure were prepared. Each formulation was prepared to contain the same amount of ceramide. More specifically, for the low-viscosity emulsified formulation, a general cream-type hair mist formulation was selected. Specifically, an O / W-type emulsified formulation containing a cationic surfactant and a higher alcohol (1-docosanol; a saturated aliphatic alcohol containing 22 carbon atoms) was used. Since the ratio of the surfactant to the higher alcohol in the low-viscosity emulsified formulation was not high, it was a formulation with a viscosity of less than 300 cSt (2 minutes, 12 rpm, 4 spindles). For the high-viscosity oil formulation, Example 1 in Table 1 was used.

[0079] Each of the formulations (low-viscosity emulsified formulation and high-viscosity oil formulation) prepared above was treated on three hair bundles. Treatment conditions such as the formulation application amount, washing time, and shampoo amount were similarly controlled. To prepare a standard solution and a test solution for evaluating the residual amount of ceramide, ceramide was precisely weighed and dissolved in methane to prepare a standard stock solution with a concentration of 1 mg / mL. For the test solution, 0.1 g was precisely weighed in the case of untreated hair bundles, and 0.05 g was precisely weighed in the case of hair bundles treated with each formulation (low-viscosity emulsifier type and high-viscosity oil formulation). Then, methanol was added to make it 10 mL, and ultrasonic extraction was performed for 1 hour.

[0080] To prepare a hair cross-section sample, the hair bundle sample was cut to a length of 2 cm, placed in a mold with O.C.T compound (Tissue-TeK) added, positioned so that no bubbles were formed between the hairs, and the hair was fixed with liquid nitrogen. Then, using a Cryotome (CM1850-7-1), it was cut into sections with a thickness of 5 μm or 10 μm to evaluate the residual amount of ceramide. Then, the residual amount of ceramide was calculated using MS Condition and UPLC.

[0081] As a result of the analysis, it was found that in the group (test group) to which the high-viscosity oil formulation was applied, the residual amount of ceramide in the hair was about 1.63 times higher after 7 cumulative treatments compared to the group (control group) to which the low-viscosity emulsified formulation was applied.

[0082] Such results indicate that the high-viscosity oil preparation according to one aspect of the present disclosure is even more effective in delivering and retaining ceramides in hair, which is also consistent with the results confirmed in the above "3. Evaluation of feel and persistence of moisturizing effect".

[0083] 5. Evaluation of penetration effect of ceramide in hair When the composition of the high-viscosity oil preparation according to one aspect of the present disclosure was applied to hair, it was evaluated whether ceramides effectively penetrated into the hair.

[0084] First, a high-viscosity oil preparation containing ceramides was prepared. Specifically, Example 1 in Table 1 was used as the high-viscosity oil preparation.

[0085] An untreated white hair bundle (control group) and a white hair bundle treated with Example 1 (test group) were prepared, and then cut to a length of 2 cm and placed in a mold with O.C.T compound (Tissue-TeK) added to fix the hair. Then, a cryotome (CM1850-7-1) was used to cut sections with a thickness of 10 μm for analyzing the hair cross-section.

[0086] The image was mosaicked using an objective lens microscope, and then a point was specified to obtain a real-time Raman spectrum. The peak of ceramides was identified and extracted from the Raman spectrum and visualized by chemical image processing.

[0087] As a result of the analysis, clear penetration of ceramides in the cuticle layer of the hair was observed in the test group to which the composition of the example was applied, as compared with the untreated group (right photograph in Figure 3; ceramides are shown in red).

[0088] Such results indicate that the high-viscosity oil preparation according to one aspect of the present disclosure is even more effective in delivering and retaining ceramides in hair, which is also consistent with the results confirmed in the above "3. Evaluation of feel and persistence of moisturizing effect".

Claims

1. An anhydrous composition comprising a fatty alcohol, an emollient, a wax, and a poorly soluble substance, having a viscosity at 30 °C of 300 cSt or more.

2. The anhydrous composition according to claim 1, wherein the fatty alcohol is a C14-22 saturated fatty alcohol.

3. The anhydrous composition according to claim 1, wherein the fatty alcohol is at least one selected from the group consisting of myristyl alcohol, cetyl alcohol, stearyl alcohol, and behenyl alcohol.

4. The anhydrous composition according to claim 1, wherein the emollient is at least one selected from the group consisting of an ester-based emollient, a triglyceride-based emollient, and a hydrocarbon-based emollient.

5. The anhydrous composition according to claim 4, wherein the ester-based emollient is an ester of a C3-C14 carboxylic acid and a C3-C20 alcohol.

6. The anhydrous composition according to claim 4, wherein the ester-based emollient is at least one selected from the group consisting of cetyl ethylhexanoate, C12-15 alkyl benzoate, and isopropyl myristate.

7. The anhydrous composition according to claim 4, wherein the triglyceride-based emollient is an ester of a C8-C10 carboxylic acid and glycerol.

8. The anhydrous composition according to claim 4, wherein the triglyceride-based emollient is at least one selected from the group consisting of glyceryl tri(caprylate / caprate), camellia oil, and abyssinian oil.

9. The anhydrous composition according to claim 4, wherein the hydrocarbon-based emollient is at least one selected from the group consisting of hydrogenated polyisobutene, squalane, squalene, and polybutene.

10. The anhydrous composition according to claim 1, wherein the wax is a natural wax.

11. The anhydrous composition according to claim 1, wherein the melting point of the wax is 25-75 °C.

12. The anhydrous composition according to claim 1, wherein the wax is at least one selected from the group consisting of jojoba ester, mango (Mangifera indica) seed butter, astrocaryum murumuru seed butter, and hydrogenated vegetable oil.

13. The anhydrous composition according to claim 1, wherein the poorly soluble substance is at least one selected from the group consisting of ceramide, madecassoside, hyaluronic acid, retinol, retinoid, coenzyme Q-10, ursolic acid, oleanolic acid, lipoic acid, protein, and water-soluble substances.

14. The anhydrous composition according to claim 13, wherein the ceramide is at least one selected from the group consisting of ceramide NS, ceramide AS, ceramide EOS, ceramide NDS, ceramide ADS, ceramide EODS, ceramide NP, ceramide AP, ceramide EOP, ceramide NH, ceramide AH, and ceramide EOH.

15. The anhydrous composition according to claim 1, further comprising at least one of dimethicone, dimethiconol, cyclomethicone, and oil.

16. The anhydrous composition according to claim 1, wherein the fatty alcohol, the emollient, and the wax form particles.

17. The anhydrous composition according to claim 1, wherein the anhydrous composition does not contain a surfactant.

18. The anhydrous composition according to claim 1, wherein the anhydrous composition is for hair.

19. The anhydrous composition according to claim 1, wherein the anhydrous composition is an anhydrous cosmetic composition.

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