Two-layer liquid containing cannabidiol and the like, and ingestion method thereof

Abstract

To realize effects such as prolonged duration of efficacy and improved taste quality by allowing oil and an acidic aqueous solution to separate after a predetermined time elapses following their mixing.SOLUTION: A liquid containing a cannabinoid such as cannabidiol comprises an edible oil in which a cannabinoid is dissolved and an edible acidic aqueous solution, the liquid having a separation state S1 of the oil and the acidic aqueous solution and a mixed state S2 of the oil and the acidic aqueous solution, and becoming the separation state S1 after a predetermined time has elapsed in the mixed state S2. A ratio of amounts of the oil and the acidic aqueous solution may be 1:9 to 9:1; the cannabinoid may be a cannabidiol-type compound; the acidic aqueous solution may be a citric acid aqueous solution; an edible saccharide may be dissolved in the acidic aqueous solution; and dissolution of the saccharide may be saturated. An ingestion method of the cannabinoid-containing liquid comprises a stirring step P1 of stirring the oil and the acidic aqueous solution in the separation state S1 to generate a mixed portion K, and an ingestion step P2 of ingesting the mixed portion K before the mixed portion K disappears and the separation state S1 is reached.SELECTED DRAWING: Figure 1

Description

[Technical Field]

[0001] The present invention relates to a liquid containing a cannabinoid such as cannabidiol, and a method for ingesting the cannabinoid-containing liquid. [Background technology]

[0002] Conventionally, methods for making cannabinoids hydrophilic have been known (see Patent Document 1). The method includes heating a base oil, such as vegetable glycerin, to a temperature in the range of 120-220°F; adding a cannabinoid, such as cannabidiol (CBD), to prepare a mixture; blending the mixture at high speed; adding an emulsifier, such as gum arabic or sunflower lecithin, to the mixture while blending; and adding water to form a composition in which the cannabinoid is hydrophilic and water soluble. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Special Publication No. 2019-511580 Summary of the Invention [Problem to be solved by the invention]

[0004] These cannabinoids are contained in the stems and seed coats of hemp plants and contain various components such as cannabidiol (CBD).Cannabidiol and other compounds have unique effects, such as reducing stress and providing a sense of relaxation, and are widely used in the medical field, such as in pharmaceutical preparations, and in the food field, such as in food additives, making them highly useful components. However, the method described in Patent Document 1 has the problem that the duration of cannabinoid efficacy is short due to emulsification. Furthermore, the method of Patent Document 1 merely uses vegetable glycerin or the like as a base oil, and therefore the taste is not satisfactory.

[0005] In view of these points, the present invention aims to provide a cannabinoid-containing liquid and a method for ingesting the same, which can achieve "extended efficacy" and "improved palatability" by being in a mixed state of oil and an acidic aqueous solution and then separating the oil and the acidic aqueous solution after a predetermined time has passed. [Means for solving the problem]

[0006] The liquid containing cannabinoid of the present invention is a liquid containing cannabinoid, and contains an edible oil in which the cannabinoid has been dissolved and an edible acidic aqueous solution, and has a separated state in which the oil and the acidic aqueous solution are separated, and a mixed state in which the oil and the acidic aqueous solution are mixed, and its first feature is that it enters the separated state after a predetermined time has passed since it entered the mixed state.

[0007] A second feature of the containing liquid according to the present invention is that, in addition to the first feature, the ratio of the amounts of the oil and the acidic aqueous solution in the separated state is 1:9 to 9:1.

[0008] A third feature of the liquid containing the present invention is that, in addition to the first feature, the cannabinoid is at least one of a cannabidiol-type compound, a cannabinol-type compound, a cannabigerol-type compound, and a cannabichromene-type compound.

[0009] A fourth feature of the containing liquid according to the present invention is that, in addition to the first feature, the acidic aqueous solution is an edible citric acid aqueous solution.

[0010] A fifth feature of the liquid according to the present invention is that, in addition to the first feature, edible carbohydrates are dissolved in the acidic aqueous solution.

[0011] A sixth feature of the liquid according to the present invention is that, in addition to the fifth feature, the carbohydrate is saturated in the acidic aqueous solution.

[0012] These features allow the edible oil and edible acidic aqueous solution to reach a mixed state S2 and then separate state S1 after a predetermined time has passed, which, unlike Patent Document 1, means that not only the cannabinoid dissolved in the oil but also the acidic aqueous solution can be ingested at the same time, thereby lengthening the duration of the cannabinoid's efficacy (the efficacy is gradually exerted, thereby "extending the duration of efficacy") and preventing the efficacy from quickly fading. At the same time, the refreshing taste of the acidic aqueous solution is imparted to the liquid containing the cannabinoid, which can be said to "improve the taste." In addition, since the liquid containing cannabinoids according to the present invention can be said to be a "two-layered liquid containing cannabidiol, etc." in the separated state S1, where the oil and the acidic aqueous solution are separated into two layers, in addition, in the mixed state S2, the oil in which the cannabinoids are dissolved and the acidic aqueous solution are mixed to form a substantially uniform state, it can be said that at least a portion of the cannabinoids are also dissolved in the acidic aqueous solution.

[0013] Furthermore, by setting the ratio of the amount of oil to the amount of acidic aqueous solution in the separated state S1 to 1:9 to 9:1, it is possible to simultaneously ingest the cannabinoids dissolved in the oil and the acidic aqueous solution, ensuring "extended efficacy" and "improved palatability," while also allowing the cannabinoid content to be adjusted to suit one's preferences. The cannabinoid may be a cannabidiol-type compound, a cannabinol-type compound, a cannabigerol-type compound, or a cannabichromene-type compound.

[0014] Furthermore, since the acidic aqueous solution is an edible citric acid aqueous solution, the refreshing taste of lemon or the like is imparted to the containing liquid. Furthermore, because edible carbohydrates are dissolved in the acidic aqueous solution, the liquid becomes sweeter and more delicious, resulting in a further ``improvement in taste.'' The acidic aqueous solution also becomes more like gum syrup, and the liquid containing the acidic aqueous solution and oil in the mixed state S2 has an increased osmotic pressure (the osmotic pressure becomes higher than that of the person or animal that ingests it, resulting in an osmotic pressure difference), which can be said to increase the absorption rate (``improvement in absorption rate''). In addition, the solubility of carbohydrates in the acidic aqueous solution is saturated, which further improves the absorption rate.

[0015] A first feature of the method for ingesting a cannabinoid-containing liquid according to the present invention is that the cannabinoid-containing liquid contains an edible oil in which the cannabinoid has been dissolved and an edible acidic aqueous solution, the cannabinoid-containing liquid having a separated state in which the oil and the acidic aqueous solution are separated, and a mixed state in which the oil and the acidic aqueous solution are mixed, the mixed state of the cannabinoid-containing liquid being reached after a predetermined time has elapsed since the mixed state, the method comprising a stirring step of stirring the oil and the acidic aqueous solution in the separated state to produce a mixed portion in which the oil and the acidic aqueous solution are mixed, and an intake step of ingesting the mixed portion before the mixed portion produced in the stirring step disappears and the cannabinoid-containing liquid enters the separated state.

[0016] Due to this feature, the method comprises a stirring step P1 in which the oil and acidic aqueous solution in the separated state S1 are stirred to produce a mixed portion K, and an intake step P2 in which the mixed portion K produced in the stirring step P1 is ingested before the mixed portion K disappears and the separated state S1 is reached. Unlike Patent Document 1, this method allows not only the cannabinoid dissolved in the oil but also the acidic aqueous solution to be ingested at the same time, thereby "extending the duration of efficacy" of the cannabinoid, preventing the efficacy from quickly disappearing, and also "improving the taste." Furthermore, the method of ingesting the liquid containing cannabidiol according to the present invention can also be said to be a method of ingesting a liquid containing cannabidiol, etc., in which the edible oil and the acidic aqueous solution are separated into two layers in the separated state S1, and therefore can also be said to be a "two-layered method of ingesting a liquid containing cannabidiol, etc." [Effects of the Invention]

[0017] According to the cannabinoid-containing liquid such as cannabidiol of the present invention and the method of ingestion thereof, the oil and the acidic aqueous solution are mixed together and then separated after a predetermined time has passed, thereby realizing "extended efficacy" and "improved taste". [Brief explanation of the drawings]

[0018] [Figure 1] 1(a) and 1(b) are photographs showing the liquid-containing composition according to the present invention, in which (a) shows a separated state, (b) shows a mixed state, (c) shows an enlarged view of the mixed portion of the mixed state, and (d) shows a coexisting state in the process of changing from a mixed state to a separated state. Note that in Fig. 1(a), the part visible between the oil portion indicated by the symbol A and the acidic aqueous solution portion indicated by the symbol M is a photograph taken obliquely from above, so only the surface of the oil portion that is in contact with the acidic aqueous solution portion is visible. [Figure 2] 1 is a flowchart showing a method for taking a liquid containing substance according to the present invention, in which (a) shows a first embodiment, (b) shows a second embodiment, and (c) shows a third embodiment. DETAILED DESCRIPTION OF THE INVENTION

[0019] Hereinafter, an embodiment of the present invention will be described with reference to the drawings. <Contained liquid> As shown in FIG. 1, the liquid according to the present invention is a liquid containing a cannabinoid, which will be described later. The liquid contains oil and an acidic aqueous solution, which will be described later, and has a separated state S1, which will be described later, and a mixed state S2, which will be described later. The containing liquid is in a mixed state S2, and after a predetermined time has elapsed, which will be described later, it is in a separated state S1.

[0020] In the containing liquid, the oil and the acidic aqueous solution may be present in approximately equal amounts. The containing liquid may particularly contain a citric acid aqueous solution, a carbohydrate, or the like, which will be described later. The container containing the containing liquid is not particularly limited, and may be, for example, a small bottle-shaped container with a dropper attached to a lid or stopper (dropper bottle), a small bottle-shaped container with a needle-shaped opening through which the containing liquid flows out (needle bottle), or a tank-shaped container with a larger capacity (polyethylene tank), etc. Alternatively, the containing liquid may be contained in a bag-shaped package made of synthetic resin.

[0021] <Cannabinoids> The cannabinoid may be, for example, at least one of a cannabidiol (CBD) type compound, a cannabinol (CBN) type compound, a cannabigerol (CBG) type compound, and a cannabichromene (CBC) type compound. It can also be said that the cannabinoids in this invention exclude (do not contain) those that are or may become subject to regulation at least in Japan. However, in fact, there are at least 104 types of cannabinoids, which are explained in detail below.

[0022] Cannabinoids are compounds with 21 carbon atoms, and the 104 types are broken down into 8 types of cannabidiol (CBD), 10 types of cannabinol (CBN), 17 types of cannabigerol (CBG), 8 types of cannabichromene (CBC), 18 types of Δ9-tetrahydrocannabinol (Δ9-Tetrahydroocannabinol, Δ9-THC), 2 types of Δ8-tetrahydrocannabinol (Δ8-Tetrahydroocannabinol, Δ8-THC), 9 types of cannabinotriol (CBT), 5 types of cannabielsoin (CBE), 3 types of cannabicyclol (CBL), 2 types of cannabinodiol (CBND), and 22 unclassified types. It can be said that cannabinoids include those derived from these 104 species and those synthesized. Also, cannabinoids may contain at least two or more types simultaneously (combination of two or more types) of the above-mentioned 104 species, derivatives, or synthetic cannabinoids. Here, the term "cannabidiol-type compound" in the present invention refers to compounds including the eight types of cannabidiol (CBD) described above, as well as compounds derived from or synthesized from these types. Similarly, hereinafter, "cannabinol-type compounds" in the present invention refer to compounds including the 10 types of cannabinol (CBN) described above, as well as compounds derived from or synthesized by these types; "cannabigerol-type compounds" in the present invention refer to compounds including the 17 types of cannabigerol (CBG) described above, as well as compounds derived from or synthesized by these types; and "cannabichromene-type compounds" in the present invention refer to compounds including the 8 types of cannabichromene (CBC) described above, as well as compounds derived from or synthesized by these types.

[0023] <Oil> As shown in Figure 1, the oil has the above-mentioned cannabinoids dissolved in it and is edible. In the present invention, "oil" refers to fats and oils that are liquid at room temperature (for example, 15 to 25°C). In addition, "edible" in the present invention means something that can be ingested by humans or animals as food or drink. Specific examples of edible oils are not particularly limited, but include vegetable oils such as salad oil, refined soybean oil, corn oil, soybean oil, sesame oil, rapeseed oil, canola oil, kaya oil, rice bran oil, rice bran oil, camellia oil, safflower oil, safflower oil, coconut oil, palm kernel oil, cottonseed oil, sunflower oil, perilla oil, perilla oil, linseed oil, olive oil, peanut oil, almond oil, avocado oil, hazelnut oil, walnut oil, grapeseed oil, mustard oil, lettuce oil, and Akebia oil, as well as animal oils such as fish oil, whale oil, shark oil, liver oil, and chrysalis oil.

[0024] In the present invention, "dissolution" means to dissolve or dissolve, and particularly refers to the phenomenon in which a gas, liquid, or solid mixes with another liquid or solid to form a homogeneous state. For example, it refers to the dissolution and mixing of solutes such as the above-mentioned cannabinoids, acids (acidic substances) described below, and carbohydrates in liquids (solvents) such as the above-mentioned oils and water to form a homogeneous liquid. In particular, dissolution in oil is referred to as "oil-soluble," and dissolution in water is referred to as "water-soluble." The concentration (wt%) of the cannabinoid dissolved in the oil is not particularly limited, but may be, for example, 1% to 90%. More specifically, the lower limit may be 1% or more, preferably 2% or more, and more preferably 4% or more, and the upper limit may be 90% or less, preferably 80% or less, more preferably 60% or less, and even more preferably 40% or less. Note that each lower limit of the concentration may be combined with any of the upper limits.

[0025] <Aqueous acid solution, citric acid solution> As shown in FIG. 1, the acidic aqueous solution is contained in the containing liquid together with the oil mentioned above and is edible. In the present invention, the term "acidic aqueous solution" refers to a liquid in which an acid (acidic substance) is dissolved in water (water solution), and in this liquid, hydrogen ions H + is occurring. Specific examples of acidic aqueous solutions are not particularly limited, but include, for example, citric acid aqueous solutions, as well as acetic acid aqueous solutions (so-called vinegar), malic acid aqueous solutions, tartaric acid aqueous solutions, succinic acid aqueous solutions, gluconic acid aqueous solutions, phosphoric acid aqueous solutions, lactic acid aqueous solutions, and carbonic acid aqueous solutions (carbonated water), which are naturally edible. More specifically, a citric acid solution is a liquid in which the acidic substance citric acid (C(OH)(CH2COOH)2COOH) is dissolved in water (water-soluble), an acetic acid solution is a liquid in which the acidic substance acetic acid (CH3COOH) is dissolved in water, a malic acid solution is a liquid in which the acidic substance malic acid (HOOC-CH(OH)-CH2-COOH) is dissolved in water, a tartaric acid solution is a liquid in which the acidic substance tartaric acid ((CH(OH)COOH)2) is dissolved in water, and a succinic acid solution is Aqueous solutions of succinic acid (HOOC-(CH2)2-COOH), an acidic substance, are dissolved in water; aqueous solutions of gluconic acid are solutions of gluconic acid (HOCH2(HCOH)4COOH), an acidic substance, are dissolved in water; aqueous solutions of phosphoric acid are solutions of phosphoric acid (H3PO4), an acidic substance, are dissolved in water; aqueous solutions of lactic acid are solutions of lactic acid (CH3CH(OH)COOH), an acidic substance, are dissolved in water; and aqueous solutions of carbonated acid are solutions of carbon dioxide (H2CO3), an acidic substance, are dissolved in water. The aqueous solutions of carbonated acid may contain carbon dioxide gas (so-called carbonated drinks).

[0026] The concentration (wt %) of the acidic substance dissolved in such an acidic aqueous solution is not particularly limited, and may be, for example, 0.1% or more and 50.0% or less. More specifically, the lower limit may be 0.1% or more, preferably 0.2% or more, and more preferably 0.4% or more, and the upper limit may be 50.0% or less, preferably 40.0% or less, and more preferably 30.0% or less. Note that each lower limit of the concentration may be combined with any of the upper limits. The hydrogen ion exponent (pH) of the acidic aqueous solution is not particularly limited, and may be, for example, 0.5 or more and 6.0 or less, or more specifically, the lower limit may be 0.5 or more, preferably 1.0 or more, more preferably 1.5 or more, and even more preferably 2.0 or more, and the upper limit may be 6.0 or less, preferably 5.0 or less, more preferably 4.0 or less, and even more preferably 3.5 or less. Each lower limit of the hydrogen ion exponent may be combined with any of the upper limits.

[0027] <Carbohydrates> The carbohydrate is dissolved in the above-mentioned acidic aqueous solution and is edible. The carbohydrate may be saturated in the acidic aqueous solution. In the present invention, "carbohydrates" refers to carbohydrates excluding dietary fiber, and includes the sugars described below, as well as trisaccharides or higher polysaccharides, sugar alcohols, and other substances. Here, "carbohydrates" in the present invention refer to sugars and their related compounds (compounds that can be expressed by a chemical formula in which carbon and water are bonded, and are composed of carbon, hydrogen, and oxygen). In addition, "other substances contained in carbohydrates" in the present invention refer to synthetic sweeteners such as acesulfame potassium and sucralose, and acidulants. In particular, sugar alcohols and synthetic sweeteners are collectively referred to as artificial sweeteners. Furthermore, in the present invention, "sugars" refers to the above-mentioned carbohydrates, excluding trisaccharide or higher polysaccharides such as oligosaccharides such as raffinose and powdered sugar (maltodextrin), sugar alcohols, and other substances, and refers to monosaccharides such as fructose and glucose, and disaccharides such as sucrose, lactose, and maltose. When such carbohydrates are dissolved in an acidic aqueous solution, the acidic aqueous solution can be said to become like gum syrup.

[0028] The maximum amount to which a solute such as the carbohydrates mentioned above will no longer dissolve is called "solubility," and generally changes depending on the temperature. The "solubility" of carbohydrates, for example, the "solubility" of sucrose in 100 g of water is approximately 198 g at a temperature of 20°C and approximately 203 g at a temperature of 25°C. However, in the present invention, carbohydrates are dissolved not in water but in an acidic aqueous solution in which an acidic substance has already been dissolved in water, which is a difference. However, when an acidic substance dissolves in water, it actually releases hydrogen ions H + combines with water molecules H2O to form oxonium ions H3O +On the other hand, when carbohydrates such as fructose and sucrose dissolve in water, the hydrogen atom H of the hydroxyl group -OH of the carbohydrate dissolves in water and dissolves by combining (hydrogen bonding) with the oxygen atom O of the water molecule HO. Therefore, since acidic substances and carbohydrates dissolve in completely different ways, it can be said that the "solubility" of acidic substances and carbohydrates does not affect each other. For example, the "solubility" of sucrose in an "acidic aqueous solution" is about 198 g at a temperature of 20°C and about 203 g at a temperature of 25°C in 100 g of acidic aqueous solution. Furthermore, the "solubility" of sucrose changes significantly at temperatures other than 20°C or 25°C. For example, as the temperature decreases, at 10°C the solubility is approximately 190g. Conversely, as the temperature increases, at 30°C the solubility is approximately 216g, at 40°C the solubility is approximately 235g, at 50°C the solubility is approximately 256g, at 60°C the solubility is approximately 287g, at 70°C the solubility is approximately 320g, at 80°C the solubility is approximately 363g, at 90°C the solubility is approximately 417g, and at 100°C the solubility is approximately 492g. It can be said that such significant changes are also observed in other carbohydrates such as fructose.

[0029] Based on these considerations, the term "saturated" in the present invention refers to a state in which, under certain conditions (for example, the temperature of the solvent such as an acidic aqueous solution or water is 20°C or 25°C, i.e., room temperature), the amount of solute such as carbohydrate dissolved in the solvent such as an acidic aqueous solution or water is increased until it reaches a maximum where no more solute dissolves, and this state is also called a saturated state. In other words, even if the carbohydrate reaches its maximum limit of insolubility when the temperature of the acidic aqueous solution is 20°C, it is possible that the carbohydrate will dissolve further when the temperature of the acidic aqueous solution is 40°C or 60°C. However, if the carbohydrate reaches its maximum limit of insolubility when the temperature of the acidic aqueous solution is 20°C or 25°C, the carbohydrate may dissolve further at a higher temperature such as 40°C or 60°C, or conversely, the carbohydrate that was dissolved at a lower temperature such as 10°C may no longer dissolve and may come out (even if some of it crystallizes), which is considered to be a saturated state. In addition, in a saturated state, an acidic aqueous solution saturated with carbohydrates becomes like gum syrup, as described above. It can also be said that the acidic aqueous solution and oil do not spoil (go rancid). Here, the temperature of the solvent in the present invention is, for example, the temperature of the solvent at 1 atmosphere (1 atm or 1013 hPa), or so-called normal pressure.

[0030] <Separate state S1 and mixed state S2, etc.> As shown in FIG. 1, the separated state S1 is a state in which the oil and the acidic aqueous solution are separated, and the mixed state S2 is a state in which the oil and the acidic aqueous solution are mixed. As described above, the containing liquid changes to the mixed state S2 and then changes to the separated state S1 after a predetermined time has elapsed. This predetermined time can be called the "separation time from mixing" and is not particularly limited, but may be, for example, 1 minute or more and 30 minutes or less (about 10 minutes, etc.), and more specifically, the lower limit may be 1 minute or more, preferably 2 minutes or more, and more preferably 4 minutes or more, and the upper limit may be 30 minutes or less, preferably 20 minutes or less, and more preferably 15 minutes or less. Note that each lower limit of this "separation time from mixing" may be combined with any of the upper limits. Furthermore, the period between the mixed state S2 and the separated state S1 (the period from the mixed state S2 to the separated state S1) can also be said to be a coexistence state S3 in which the mixed state S2 and the separated state S1 coexist (see Figure 1(d)).

[0031] <Ratio of oil to acidic aqueous solution> In a single container containing the containing liquid, in the separated state S1, the amount of oil and the amount of acidic aqueous solution may be approximately the same (approximately the same amount, i.e., the ratio of the amount of oil to the amount of acidic aqueous solution may be 5:5 (=1:1)). Alternatively, in the separated state S1, the ratio of the amount of oil to the amount of acidic aqueous solution may be 1:9 to 9:1 (1:9 or more and 9:1 or less), or 1:7 to 7:1 (1:7 or more and 7:1 or less), or more specifically, the lower limit may be 1:9 or more, preferably 2:8 or more, more preferably 3:7 or more, even more preferably 4:6 or more, or the upper limit may be 9:1 or less, preferably 8:2 or less, even more preferably 7:3 or less, even more preferably 6:4 or less. Note that each lower limit of this ratio may be combined with any of the upper limits. The ratio of the amounts of oil and acidic aqueous solution in the separated state S1 does not have to be 1:9 to 9:1 (1:9 or more and 9:1 or less), and may be, for example, greater than 0:10 and less than 1:9 (e.g., 0.5:9.5), or greater than 9:1 and less than 10:0 (e.g., 9.5:0.5). No matter how little the amounts of oil and acidic aqueous solution are, the amount never becomes 0 (zero) (i.e., the ratio of the amounts never becomes 0:10 or 10:0). Here, in the present invention, "substantially the same amount" means, for example, that if the ratio of the amount of oil to the amount of acidic aqueous solution is a volume ratio in ml (milliliters), the difference between the amount of oil and the amount of acidic aqueous solution is 1 ml or less; if the ratio of the amount of oil to the amount of acidic aqueous solution is a weight ratio in mg (milligrams), the difference between the amount of oil and the amount of acidic aqueous solution is 1 mg or less. Furthermore, even if the ratio of the amounts of oil and acidic aqueous solution in the separated state S1 is initially approximately the same (the ratio of the amount of oil to the amount of acidic aqueous solution is 5:5), when the liquid containing the oil is ingested several times, it is possible that more of either the oil or the acidic aqueous solution is ingested. Therefore, even if the ratio of the amounts of oil and acidic aqueous solution in the separated state S1 is 4.5:5.5 to 5.5:4.5 (4.5:5.5 or more and 5.5:4.5 or less), it can be said that the amounts of oil and the amount of acidic aqueous solution are approximately the same. Each unit may be a larger unit (for example, l (liter) or g (gram)).

[0032] <Mixing ratio R, mixed portion K, etc.> The mixing ratio of the oil and the acidic aqueous solution (hereinafter referred to as "mixing ratio R") is not particularly limited, but for example, between the mixed state S2 and the separated state S1 (i.e., the coexistence state S3), the mixing ratio R may be greater than 0% and less than 100%, or 1% to 99%. Alternatively, the lower limit may be greater than 0%, or the lower limit may be 1% or more, preferably 10% or more, and more preferably 20% or more. The upper limit may be less than 100%, or 99% or less, preferably 90% or less, and more preferably 80% or less. Note that each lower limit of the mixing ratio R may be combined with any of the upper limits. Here, the "mixing ratio R" in the present invention is calculated by calculating the amounts (volumes, etc.) of the oil portion (the portion indicated by symbol A in FIG. 1) which is the oil portion described above, the acidic aqueous solution portion (the portion indicated by symbol M in FIG. 1) which is the acidic aqueous solution portion described above, and the mixed portion (the portion indicated by symbol K in FIG. 1) which is the mixture of the oil and the acidic aqueous solution, using the symbols A, M, and K, from the formula "R(%)=K(ml) / {A(ml)+M(ml)+K(ml)}×100." If the amount in this formula is weight, the unit will be mg, or the like, and these units may also be larger units (e.g., l (liter) or g (gram)).

[0033] 1, the oil portion A exists in a separated state S1 and a coexisting state S3, the acidic aqueous solution portion S also exists in a separated state S1 and a coexisting state S3, and the mixed portion K exists in a mixed state S2 and a coexisting state S3. In other words, in the separated state S1, only the oil portion A and the acidic aqueous solution portion M exist (i.e., the mixing ratio R is 0%), in the mixed state S2, only the mixed portion K exists (i.e., the mixing ratio R is 100%), and in the coexisting state S3, the oil portion A, the acidic aqueous solution portion M, and the mixed portion K coexist. Therefore, in the coexisting state S3, the mixing ratio R can be said to be greater than 0% and less than 100%. In particular, as shown in Figures 1(c) and (d), if carbohydrates are dissolved in the acidic aqueous solution (especially if it is saturated), the mixed portion K will become like gum syrup, and it can also be said that the mixed portion K will become in a hazy state. Furthermore, as shown in Figure 1(d), between the mixed state S2 and the separated state S1, the acidic aqueous solution portion M gradually appears from the bottom of the container containing the liquid, and the oil portion A gradually appears from the top of the container. As described above, in the mixed portion K, the oil in which the cannabinoids are dissolved and the acidic aqueous solution are mixed to form a substantially uniform state, so it can be said that at least a portion of the cannabinoids are also dissolved in the acidic aqueous solution, and this mixing ratio R can be said to represent the rate at which the cannabinoids are dissolved in water.

[0034] <Cannabinoids in Mixture K and their Content> It can be said that such a mixed portion K can be formed regardless of the ratio of the amounts of oil and acidic aqueous solution in the above-described separated state S1. For example, even if the ratio of the amount of oil to the amount of acidic aqueous solution is 1:9 or 9:1 in the separated state S1, the oil and the acidic aqueous solution will mix to form the mixed portion K, and in this case, the oil and the acidic aqueous solution will exist in the mixed portion K at an amount ratio of 1:9 or 9:1. It can also be said that when the ratio of the amount of oil to the amount of acidic aqueous solution is 1:9 or 9:1, the above-described "separation time from mixing" is shorter than when the ratio of the amount of oil to the amount of acidic aqueous solution is 5:5 (approximately the same amount). Taking these points into consideration, and referring to the ratio of the amounts of oil to the acidic aqueous solution and the cannabinoid content (wt%), the cannabinoid content in the containing liquid is, for example, if the ratio of the amount of oil to the amount of acidic aqueous solution is 5:5 and the concentration (wt%) of cannabinoids dissolved in the oil is 90%, then the cannabinoid content in the containing liquid (i.e. the total amount of oil and acidic aqueous solution combined) will be only half that, 45% (i.e. 0.9 x 0.5 = 0.45). However, if the ratio of oil to acidic aqueous solution is 9:1 and the cannabinoid concentration is 90%, then multiplying 90% by 90% gives a cannabinoid content of 81% (i.e., 0.9 x 0.9 = 0.81); if the ratio of oil to acidic aqueous solution is 9.5:0.5, the cannabinoid content will be greater than 81%. Therefore, the cannabinoid content (wt%) in the cannabinoid-containing liquid is not particularly limited, but may be, for example, 1% to 90%. More specifically, the lower limit may be 1% or more, preferably 2% or more, and more preferably 4% or more, and the upper limit may be 60% or less, preferably 50% or less, more preferably 40% or less, and even more preferably 30% or less. Note that each lower limit of the content may be combined with any of the upper limits.

[0035] <How to take the liquid> As shown in FIG. 2, the above-mentioned method for ingesting a liquid containing the substance (hereinafter also referred to as "the ingesting method") includes at least a stirring step P1, which will be described later, and an ingesting step P2, which will also be described later. The intake method may include an opening step P1-1, a suction step P1-2, a sealing step P2-1, and the like, which will be described later, in addition to the stirring step P1 and the intake step P2. Here, in the intake method, if only the stirring step P1 and the intake step P2 are included, it is considered to be the first embodiment (see Figure 2(a)), if the container of the containing liquid is the above-mentioned dropper bottle, in particular, if it includes the stirring step P1, the opening step P1-1, the suction step P1-2, the intake step P2, and the sealing step P2-1, it is considered to be the second embodiment (see Figure 2(b)), and if the container of the containing liquid is the above-mentioned needle bottle, in particular, if it includes the stirring step P1, the opening step P1-1, the intake step P2, and the sealing step P2-1, it is considered to be the third embodiment (see Figure 2(c)).

[0036] <Stirring process P1> As shown in FIG. 2, the stirring step P1 is a step of stirring the oil and the acidic aqueous solution in the above-described separated state S1 to form a mixed state S2. In the present invention, "stirring the oil and the acidic aqueous solution in the separated state S1" means stirring the oil and the acidic aqueous solution in the separated state S1 to mix the oil and the acidic aqueous solution. Here, the means of stirring in the stirring step P1 is not particularly limited, and may be, for example, stirring by shaking the entire container containing the containing liquid, or stirring by rotating a rod, plate, propeller-shaped stirrer, or the like in the container, or spraying one of the oil and the acidic aqueous solution into a container containing only the other without using a rod or the like. In the stirring step P1, the liquid contained in the container may be stirred until it becomes entirely mixed portion K (that is, until it becomes mixed state S2), but it is sufficient to stir at least until mixed portion K is produced.

[0037] <Intake process P2> As shown in FIG. 2, the intake step P2 is a step of ingesting the mixed portion K generated in the above-described stirring step P1 before the mixed portion K disappears and the separated state S1 is reached. That is, in the intake step P2, the mixed portion K of the oil and the acidic aqueous solution is ingested while the liquid is in the mixed state S2 or the coexisting state S3. In the intake step P2, it is sufficient that at least the mixed portion K of the liquid is ingested, and the oil portion A and / or the acidic aqueous solution portion M of the liquid may be ingested simultaneously with this mixed portion K. Here, "ingestion" in the present invention means putting a liquid containing the mixed part K etc. into the body of a human or animal, and the means for this may be oral ingestion, which is also called taking it. Furthermore, in the present invention, "oral ingestion" may include dripping the liquid containing the mixed part K, etc. into the mouth (particularly onto the tongue), dripping it onto other food and eating the food, or dripping it into a drink and mixing it with the drink and drinking the drink, or may also include turning the liquid containing the mixed part K, etc. into a mist and spraying it into the mouth.

[0038] <Opening process P1-1, suction process P1-2, sealing process P2-1> As shown in FIG. 2, the opening step P1-1 is a step of opening a container containing the liquid after the above-described stirring step P1 when the container is a dropper bottle, a needle bottle, or the like. In other words, if the container has a lid, it can be said to be a process of opening the lid, and if the container has a stopper, it can be said to be a process of opening the stopper.

[0039] As shown in FIG. 2, the suction step P1-2 is a step of sucking up the mixed portion K with a dropper after the above-described opening step P1-1 when the container containing the containing liquid is a dropper bottle. In the suction step P1-2, it is sufficient to suction up at least the mixed portion K of the liquid-containing solution, and the oil portion A and the acidic aqueous solution portion M of the liquid-containing solution may be suctioned up together with the mixed portion K. In the intake step P2 after the suction step P1-2, the tip of the dropper may be positioned above the tongue or in the mouth of a person or animal to receive the sucked-up mixed portion K or the like. The dropper may be attached to the lid or stopper of a container containing the liquid, or may be separate from the lid or stopper.

[0040] As shown in FIG. 2, the sealing step P2-1 is a step of sealing the container after the above-mentioned intake step P2 when the container containing the liquid is a dropper bottle, a needle bottle, or the like. In other words, if the container has a lid, it can be said to be a process of closing the lid, and if the container has a stopper, it can be said to be a process of putting the stopper back on.

[0041] <Other> The present invention is not limited to the above-described embodiment. The individual components of the liquid and the method of taking the liquid, as well as the overall structure, shape, and dimensions, can be modified as appropriate in accordance with the spirit of the present invention. The containing liquid may not contain an emulsifier, a surfactant, or a dispersant. The carbohydrate does not have to be dissolved in the acidic aqueous solution, and even if the carbohydrate is dissolved in the acidic aqueous solution, it does not have to be saturated.

[0042] Here, even when carbohydrates are dissolved, not being saturated means that under certain conditions (for example, the temperature of the solvent such as an acidic aqueous solution or water is 20°C or 25°C), the amount of solute such as carbohydrates dissolved in the solvent such as an acidic aqueous solution or water has not reached the maximum level at which it no longer dissolves (i.e., a non-saturated state). In such a non-saturated state, the concentration (wt%) of carbohydrate dissolved in a solvent such as an acidic aqueous solution or water is not particularly limited, but its upper limit is the solubility at each temperature (for example, the solubility of sucrose in 100 g of water is approximately 198 g at 20°C, meaning that approximately twice as much sucrose dissolves as in water). Therefore, it may be, for example, 1% or more and 500% or less. More specifically, the lower limit may be 1% or more, preferably 10% or more, and even more preferably 100% or more. The upper limit, although depending on the temperature of the solvent as described above, may be 500% or less, preferably 400% or less, more preferably 300% or less, and even more preferably 250% or less. Note that each lower limit of the concentration may be combined with any of the upper limits. Also, the acidic aqueous solution in which carbohydrates are dissolved is <1> First, an acidic substance may be dissolved in water to form an acidic aqueous solution, and then a carbohydrate may be further dissolved in the acidic aqueous solution. <2> First, carbohydrates are dissolved in water to obtain water with carbohydrates dissolved therein (so-called carbohydrate water such as sugar water), and then an acidic substance may be dissolved in the water with carbohydrates dissolved therein.

[0043] The oil and the acidic aqueous solution in the containing liquid may each be light red, light pink, light gold, dark brown, or a color close to black, or may be colorless and transparent. For example, if the oil is colored (e.g., light red) and the acidic aqueous solution is approximately colorless and transparent, and the ratio of the amount of oil to the amount of acidic aqueous solution in the separated state S1 is 1:9 or 9:1, the color of the mixed portion K of the oil and the acidic aqueous solution may be slightly lighter or darker than the color of the mixed portion K where the ratio of the amount of oil to the amount of acidic aqueous solution is 5:5 (approximately equal amounts), and even if the ratio of the amount of oil to the amount of acidic aqueous solution is 5:5, the color of the mixed portion K in the coexistence state S3 from the mixed state S2 to the separated state S1 may become lighter over time. If the container containing the liquid is a dropper bottle with a dropper attached to the lid or the like, when the lid is closed and the liquid is stirred, the liquid containing the oil and the acidic aqueous solution will also enter the dropper, but the oil and the acidic aqueous solution may separate even in this dropper after a predetermined time has passed. The container for the liquid may not have a lid or a stopper, and may be, for example, a cup-shaped container. In this case, in the stirring step P1, the liquid is stirred with a stick or the like, and in the intake step P2, the mixed portion K may be drunk by putting the mouth over the cup-shaped container. The method for ingesting a liquid-containing container may include steps other than the stirring step P1, the ingesting step P2, the opening step P1-1, the suction step P1-2, and the sealing step P2-1. For example, the method may include an injection step of injecting the liquid-containing container into the container before the stirring step P1 in each embodiment of the method described above. [Industrial Applicability]

[0044] The liquid containing the present invention and the method for ingestion of the liquid containing the present invention can be used as a luxury item, as well as for pharmaceutical, food, cosmetic, and animal feed applications. [Explanation of symbols]

[0045] S1 Separated state S2 mixed state P1 Stirring process P2 intake process

Claims

1. A cannabinoid-containing liquid, The cannabinoid-containing edible oil and the edible acidic aqueous solution are included. a separated state in which the oil and the acidic aqueous solution are separated, and a mixed state in which the oil and the acidic aqueous solution are mixed, The liquid is characterized in that it becomes the separated state after a predetermined time has passed since it became the mixed state.

2. The liquid according to claim 1, wherein the ratio of the amount of the oil to the amount of the acidic aqueous solution in the separated state is 1:9 to 9:

1.

3. 2. The liquid according to claim 1, wherein the cannabinoid is at least one of a cannabidiol-type compound, a cannabinol-type compound, a cannabigerol-type compound, and a cannabichromene-type compound.

4. 2. The liquid according to claim 1, wherein the acidic aqueous solution is an edible citric acid aqueous solution.

5. 2. The liquid according to claim 1, wherein edible carbohydrates are dissolved in the acidic aqueous solution.

6. 6. The solution according to claim 5, wherein the carbohydrate is saturated in the acidic aqueous solution.

7. A method for ingesting a liquid containing cannabinoids, comprising: The liquid contains an edible oil in which the cannabinoid is dissolved and an edible acidic aqueous solution, the containing liquid has a separated state in which the oil and the acidic aqueous solution are separated, and a mixed state in which the oil and the acidic aqueous solution are mixed, The liquid containing the mixture enters the separated state after a predetermined time has elapsed since the mixture was formed, a stirring step of stirring the oil and the acidic aqueous solution in the separated state to generate a mixed portion in which the oil and the acidic aqueous solution are mixed; A method for ingesting a liquid-containing solution, comprising the step of ingesting the mixed portion produced in the stirring step before the mixed portion disappears and the liquid is separated.

Images