Fungicidal combinations and methods for controlling plant pathogenic fungi

Abstract

The present invention relates to a fungicidal combination for controlling phytopathogenic fungi causing rice blast disease and a composition comprising said combination. The present invention also relates to a method for controlling or preventing Magnaporthe grisea causing rice blast disease.

Description

[Technical field]

[0001] The present invention relates to a fungicide combination and a composition comprising said combination for controlling phytopathogenic fungi. The present invention also relates to a method for controlling or preventing phytopathogenic fungi by applying said combination or composition. More specifically, the present invention relates to a method for controlling phytopathogenic fungal infections in rice crops. [Background technology]

[0002] Protecting plants from diseases that cause great and irreparable losses, damage, harm and injury to plants is essential for healthy plant growth and improved agricultural product quality. Most crops and agricultural products are subject to attack by several fungi. As fungal infections cause significant yield losses, preventing and treating fungal infections in plants and plant parts is important for high productivity and is a continuing objective in the agricultural sector.

[0003] Fungicides are a specific class of pesticides that are widely used to control fungal diseases by suppressing or killing the fungi that cause the diseases. To date, several active compounds have been discovered that have the effect of controlling various plant diseases, and various plant disease control agents containing them as active ingredients have been developed.

[0004] 1,2,4-Triazoles and their derivative compounds are one of the most biologically active classes of compounds, with a broad spectrum of activity. 1,2,4-triazole fungicides exert their antifungal activity by inhibiting C14-demethylase (a P450 enzyme), a well-known target of fungicides. 1,2,4-triazoles are economically important pesticides due to their widespread use in crops such as wheat, barley, soybean, and orchard fruits. A particularly important triazole fungicide is 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophen-yl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4-]-triazole-3-thione, or prothioconazole. Prothioconazole is a sterol demethylation inhibitor (DMI) compound and is used as a fungicide in agriculture.

[0005] Rice (Oryza sativa) is an important staple crop for the world. Its supply must therefore double by 2050 to meet the food demands of a growing population. One of the biggest obstacles to increasing rice production is the presence of rice blast (Magnaporthe oryzae), which directly reduces rice yields and indirectly increases production costs. Mainly, Rhizoctonia solani (teleomorph: Tanatephorus cucumeris), Magnaporthe grissa (teleomorph: Magnaporthe grissa), Helminthosporium oryzae (synonym: Dreschlerella oryzae), Bacterial leaf spot, Sclerotinia sclerotinia, or Sarocladium oryzae cause rice diseases that are difficult to control. The most damaging disease of rice is rice blast, caused by the heterophyllic ascomycete pathogen Magnaporthe oryzae. The disease causes symptoms on the leaves, stems, nodes, roots and panicles of rice, leading to severe yield losses.

[0006] Rice blast (Magnaporthe oryzae) accounts for approximately 30% of global rice production losses, equivalent to feeding 60 million people, making it a major concern in achieving global food security. These losses can increase the price of global rice and reduce consumer welfare and food security. Yield losses due to blast infection vary depending on the susceptibility of the variety, the extent of infection, and the timing of fungicide spraying. Yield losses associated with blast outbreaks can reach more than 50%, and the cost of mitigating blast outbreaks through fungicide spraying is high. Because blast outbreaks can occur during extreme weather conditions such as low temperatures and sudden rains in summer, blast is one of the most serious rice diseases worldwide, and there is an urgent need to develop new control strategies for blast.

[0007] Moreover, the increasing global demand for rice, especially in Asia, combined with unpredictable weather disasters in recent years has put enormous stress on rice farmers in the region, forcing them to find new ways to grow higher quality rice efficiently and sustainably.

[0008] WO 97 / 40683 discloses a composition of propiconazole and tricyclazole suitable for protecting rice from attack by Pyricularia and Rhizoctonia. However, the performance of this combination against the above-mentioned fungal rice pathogens is not yet completely satisfactory in all respects. Therefore, there is a need for agents that more efficiently control fungal pathogens on rice plants. In order to increase global food security and reduce losses due to rice blast, there is a need for mitigation of rice blast in rice cultivation. Summary of the Invention

[0009] It is therefore an object of the present invention to provide a fungicide combination which, when applied to rice plants or cultivation, has improved and / or increased and / or broader activity spectrum of fungicidal activity against phytopathogenic fungi.

[0010] Another object of the present invention is to control or prevent phytopathogenic fungi, more particularly those causing rice blast. The present invention is particularly useful for controlling a harmful fungal disease of rice, namely rice blast caused by Magnaporthe oryzae. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0011] For purposes of the following detailed description, unless expressly stated to the contrary, it is to be understood that the present invention is susceptible to various alternative variations. Further, in any operating example or unless otherwise indicated, all numerical values ​​expressing amounts of materials / ingredients used herein, for example, are to be understood as being modified in all instances by the term "about."

[0012] The term "about" when used to describe the amount of active ingredient shall be interpreted to mean "approximately" or "reasonably close," and to mean a statistically insignificant variation therefrom.

[0013] As used herein, the terms "comprising," "including," "having," "containing," "involving," and the like, shall be understood to be open-ended, meaning including but not limited to.

[0014] In any aspect or embodiment described below, the word "comprising" may be replaced with the phrase "consisting of" or "consisting essentially of." In these aspects or embodiments, the combination or composition described comprises, consists of, consists essentially of, or consists substantially of the particular ingredients described therein, excluding other ingredients or excipients not specifically described therein.

[0015] The phrase "fungicidally effective amount of a fungicide" refers to an amount of a fungicide that kills or inhibits the plant pathogenic disease that it is desired to control, and is an amount that is not significantly toxic to the plant being treated.

[0016] As used herein, the term "disease control" refers to the control and prevention of a disease as specified herein. Control effects include any deviation from natural occurrence, such as killing, delaying, inhibiting or reducing a fungal disease.

[0017] The term "phytotoxicity" refers to a toxic (negative) effect on plant growth.

[0018] The term "plant" refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, propagules, stalks, leaves and fruits.

[0019] "Fungicidal" refers to the ability of a substance to reduce or inhibit the growth of fungi.

[0020] "Control" or "controlling" with respect to fungi means inhibiting and / or suppressing the growth and / or reproductive ability of fungi, or limiting fungal damage or loss in a crop, or controlling and preventing disease. A control effect includes any deviation from the natural development, such as killing, retarding or reducing the disease.

[0021] The term "locus" as used herein refers to the vicinity of a target crop where control of phytopathogenic fungal infection is desired. Locus includes the vicinity of a target crop where phytopathogenic fungal infection has occurred, is most likely to occur, or has not yet occurred.

[0022] The term "plant propagation material" is understood to refer to the reproductive parts of plants, such as seeds, vegetative material such as cuttings and tubers, roots, fruits, bulbs, rhizomes, plant parts, germinated plants, and young plants that are to be transplanted after germination or after emerging from the soil. These young plants may be protected by a total or partial treatment by immersion before transplanting.

[0023] The term "agriculturally acceptable effective amount" refers to an amount effective to kill or inhibit the plant disease which it is desired to control, without causing significant toxicity to the treated plants.

[0024] The term "disease severity %" as used herein refers to the percentage of decay observed in a crop as a percentage of the relevant host tissue covered with lesions or damaged by the disease. Severity is determined by the number and size of the lesions. Severity % indicates the extent of damage caused by the disease.

[0025] As used herein, the term "disease control rate" refers to the rate of control and prevention of a target disease in a crop.

[0026] As used herein, the term "g ai / L" refers to the concentration of each active ingredient in "grams" present "per liter" of the composition.

[0027] As used herein, the term "g ai / h" refers to the concentration of each active ingredient in "grams" applied "per hectare" of a crop field.

[0028] Each of the above aspects may have one or more embodiments.

[0029] Each of the embodiments described below may be applicable to one or all of the aspects described above. These embodiments are intended to be read as preferred features of one or all of the aspects described above. Each of the embodiments described below is individually applicable to each of the aspects described above.

[0030] The present invention relates to fungicidal combinations, compositions containing same, and methods for controlling fungal infections in crops.

[0031] The inventors have surprisingly found that fungicide combinations comprising a demethylation inhibitor fungicide, particularly prothioconazole, show superior fungicidal activity against rice blast fungus in rice plants compared to untreated plants with no phytotoxicity. The inventors have unexpectedly found that fungicide combinations comprising a demethylation inhibitor fungicide and another fungicide show superior efficacy with synergistic effects in controlling blast disease in rice cultivation, particularly rice leaf blast and rice ear blast. More specifically, the inventors have found that combinations comprising prothioconazole and at least one strobilurin fungicide show synergistic effects in controlling blast disease in rice. Further combinations including prothioconazole and 4-quinolylacetate fungicides, i.e. tebufloquine, prothioconazole and dithiolanes, i.e. isoprothiolane, prothioconazole and kasugamycin, and prothioconazole and sulfur showed efficient control of leaf blast and neck blast caused by Magnaporthe grisea.

[0032] Thus, the present invention provides various embodiments, combinations, compositions, uses, methods for controlling, preventing or partially preventing rice blast infection in rice, or symptoms or conditions associated with rice blast infection, by applying prothioconazole or combinations thereof to affected or unaffected rice plants.

[0033] The present invention provides a fungicidal combination comprising a demethylation inhibitor fungicide and at least one fungicide for the control of phytopathogenic fungi in rice cultivation.

[0034] In one embodiment the invention provides a fungicide combination comprising a demethylation inhibitor fungicide and at least one fungicide for the control of phytopathogenic fungi in rice cultivation, in particular fungi causing neck blast and leaf blast of rice.

[0035] Thus, the present invention provides a fungicide combination comprising a demethylation inhibiting (DMI) fungicide and at least one fungicide for preventing or controlling phytopathogenic fungi in rice, in particular fungi belonging to the genus Pyricularia.

[0036] The present invention therefore relates to a fungicidal combination comprising a demethylation inhibitor fungicide, in particular a triazole compound (I), and at least one second / fungicidal compound (II) as described herein, for controlling rice blast phytopathogenic fungi in rice.

[0037] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) a demethylation inhibitor fungicide; and (ii) at least one fungicide.

[0038] In one embodiment the demethylation inhibitor fungicide is a triazole fungicide.

[0039] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) a triazole fungicide; and (ii) at least one fungicide.

[0040] According to one embodiment, the triazole fungicide (I) is selected from azaconazole, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluconazole, fluquinconazole, flusilazole, flutriafol, fluconazole, fluconazole-cis, hexaconazole, imibenconazole, ipconazole, ipfentrifluconazole, mefentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, thiabendazole, triadimefon, triadimenol, triticonazole, uniconazole and uniconazole-P, their salts, esters, isomers, derivatives, or combinations thereof.

[0041] According to a preferred embodiment, the triazole compound (I) is 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4-]-triazole-3-thione (prothioconazole), or a salt, ester, metabolite, isomer, or derivative thereof.

[0042] In one embodiment the fungicidal combination of the invention comprises prothioconazole as compound (I).

[0043] Thus, the (i) and (I) numerical references assigned to a demethylation inhibitor fungicide, or a triazole compound, or prothioconazole, are deemed to designate the fungicide as the first fungicide in a combination of fungicides.

[0044] In one embodiment the fungicide combination comprises prothioconazole and at least another fungicide compound (II) as described herein to control the phytopathogenic fungus Magnaporthe oryzae in rice.

[0045] Thus, the numerical references (ii) and (II) referring to a second fungicide in a fungicide combination are deemed to designate the fungicide as the second fungicide in the fungicide combination.

[0046] In one embodiment, the second fungicide compound (II) in combination with the triazole fungicide compound (I) is selected from the group consisting of contact fungicides, inorganic compounds, dithiocarbamate fungicides, quinone external inhibitors (QoIs), succinate dehydrogenase inhibitors (SDHIs), quinone internal inhibitors (QiIs), 4-quinolylacetic acid, hexopyranosyl antibiotics, and dithiolanes, or combinations thereof.

[0047] In a further embodiment, the second fungicide is a demethylation inhibitor fungicide.

[0048] In one embodiment the second fungicide is a quinone external inhibitor fungicide.

[0049] In another embodiment, the quinone external inhibitor is selected from strobilurin fungicides.

[0050] According to one embodiment, the strobilurin fungicide is selected from the group comprising azoxystrobin, cumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, trifloxystrobin, dimoxystrobin, phenaminestrobin, metominostrobin, orysastrobin, famoxadone, fluoxastrobin, fenamidone or pyribencarb.

[0051] In a preferred embodiment, the strobilurin fungicides include azoxystrobin, picoxystrobin, pyraclostrobin, fluoxastrobin and trifloxystrobin.

[0052] In another embodiment, the succinate dehydrogenase inhibitor (SDHI) is selected from the group including benzovindiflupyr, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid, thifluzamide, carboxin, oxycarboxin, fenfuram, fluopyram, isofetamide, benodanil, flutolanil or mepronil.

[0053] In one embodiment the contact fungicide is a multi-site fungicide selected from inorganic compounds, dithiocarbamates, phthalimides, chloronitriles, sulfamides, bisguanidines, triazines, quinones, quinoxalines, maleimides and thiocarbamates.

[0054] In one embodiment, the contact fungicide comprises amovam, asomet, azithiram, carbamorph, kufuraneb, cuprobam, disulfiram, ferbam, metham, nabam, tecoram, thiram, urvacid, ziram, dazomet, ethem, milneb, copper sulfate, dibasic copper sulfate, tribasic copper sulfate, copper oxychloride, sulfur, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb, or zineb.

[0055] In a preferred embodiment, the dithiocarbamate fungicide is mancozeb.

[0056] In a preferred embodiment, the inorganic compound is a copper salt.

[0057] In a preferred embodiment, the copper salt is tribasic copper sulfate.

[0058] In a preferred embodiment, the copper salt is copper oxychloride.

[0059] In a preferred embodiment, the inorganic compound is sulfur.

[0060] In a preferred embodiment, the inorganic compound is sulfur or a salt thereof.

[0061] In one embodiment, the quinone internal inhibitor (QII) is selected from the group comprising cyazofamid, amisulbrom, fenpicoxamid and florylpicoxamid.

[0062] In one embodiment, the second fungicide is a 4-quinolylacetic acid fungicide.

[0063] In another embodiment, the 4-quinolylacetic acid fungicide is tebufloquine.

[0064] In one embodiment, the second fungicide is a hexopyranosyl antibiotic.

[0065] In another embodiment, the hexopyranosyl antibiotic is kasugamycin.

[0066] In one embodiment, the second fungicide is a dithiolane.

[0067] In one embodiment, the dithiolane fungicide is isoprothiolane.

[0068] In one embodiment, the second fungicide is a systemic fungicide, including a nucleic acid synthesis inhibitor, a cytoskeletal and motor protein inhibitor, an amino acid and protein synthesis inhibitor, a respiratory process inhibitor, a signal transduction inhibitor, a lipid synthesis and membrane integrity disruptor, a sterol biosynthesis inhibitor, a melanin synthesis inhibitor, a cell wall biosynthesis inhibitor, a melanin synthesis inhibitor in the cell wall, a host plant defense inducer, a fungicide with an unknown mechanism of action, an unclassified fungicide, or a biologic with multiple mechanisms of action.

[0069] In some embodiments, the fungicide is metrafenone, amisulbrom, isotianil, fluopicolide, fenpyrazamine, valifenarate, mandipropamid, penflufen, bixafen, fluopyram, fluxapyroxad, isopyrazam, penthiopyrad, pyriophenone, sedaxane, pydiflumetofen, diclobentiazox, isoflucipram, fenpicoxamide, florylpicoxamide, fluoxapiproline, mefentrifluconazole, It is combined with a triazole compound (I) selected from the group consisting of ifentrifluconazole, methyltetraprole, impirfluxam, quinofumelin, oxathiapiproline, fluindapyr, dipimethitron, pyridaclomethyl, benzovindiflupyr, orysastrobin, amethoctrazine, flutianil, pyraziflumide, cumoxystrobin, pyribencarb, tebufloquine, isofetamide, tolprocarb, mandestrobin, and picarbutrazox.

[0070] In one embodiment, the fungicide combination for controlling rice blast comprises: (i) prothioconazole, (ii) a second fungicide selected from the group consisting of a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, an inorganic compound, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof.

[0071] In one embodiment, the fungicide combination for controlling rice blast comprises: (i) prothioconazole, (ii) Quinone external inhibitor (QoI) fungicides, including strobilurin fungicides.

[0072] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) at least one strobilurin fungicide.

[0073] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) Azoxystrobin.

[0074] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) picoxystrobin.

[0075] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) trifloxystrobin.

[0076] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) fluoxastrobin.

[0077] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) tebufloquine,

[0078] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) kasugamycin.

[0079] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) isoprothiolane.

[0080] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) an inorganic compound.

[0081] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising prothioconazole and a copper salt.

[0082] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) Copper salts, including copper oxychloride, copper sulfate, tribasic copper sulfate, and other such copper salts.

[0083] In one embodiment, the present invention provides a fungicide combination for controlling rice blast, the fungicide combination comprising: (i) prothioconazole, (ii) sulfur or a salt thereof.

[0084] The active ingredients used throughout the disclosure include their salts, esters, ethers, polymorphs including solvates and hydrates. Salts include salts that retain the biological effectiveness and properties of the active ingredients and are not biologically or otherwise undesirable, and also include derivatives of the disclosed compounds in which the parent compound is modified by making inorganic and organic non-toxic acid or base addition salts. Salts can be synthesized from the parent compound by conventional chemical methods.

[0085] The weight ratio of active compounds used in the fungicidal combinations of the present invention is usually from about 500:1 to about 1:500, preferably from 100:1 to 1:100, more preferably from 50:1 to 1:50, and most preferably from 25:1 to 1:25.

[0086] In one embodiment the combination of fungicides comprises a demethylation inhibitor fungicide and another fungicide in a ratio of 1:15 to 15:1.

[0087] In one embodiment the combination of fungicides comprises a demethylation inhibitor fungicide and another fungicide in a ratio of 1:10 to 10:1.

[0088] In one embodiment the combination of fungicides comprises a demethylation inhibitor fungicide and another fungicide in a ratio of 1:5 to 5:1.

[0089] In one embodiment the fungicide combination comprises a triazole fungicide and another fungicide in a ratio of 1:15 to 15:1.

[0090] In one embodiment the fungicide combination comprises a triazole fungicide and another fungicide in a ratio of 1:10 to 10:1.

[0091] In one embodiment the fungicide combination comprises a triazole fungicide and another fungicide in a ratio of 1:5 to 5:1.

[0092] In one embodiment the combination of fungicides comprises prothioconazole and another fungicide in a ratio of 1:15 to 15:1.

[0093] In one embodiment the combination of fungicides comprises prothioconazole and another fungicide in a ratio of 1:10 to 10:1.

[0094] In one embodiment the fungicide combination comprises prothioconazole and one further fungicide in a ratio of 1:5 to 5:1.

[0095] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) a demethylation inhibitor fungicide; and (ii) at least one fungicide; The ratio of the demethylation inhibitor fungicide to the second fungicide is 1:15 to 15:1.

[0096] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) a triazole fungicide; and (ii) at least one fungicide; The ratio of the triazole fungicide to the second fungicide is 1:15 to 15:1.

[0097] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) a triazole fungicide; and (ii) at least one fungicide; The ratio of the triazole fungicide to the second fungicide is 1:10 to 10:1.

[0098] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) a triazole fungicide, including prothioconazole; (ii) a second fungicide selected from the group including a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, an inorganic compound, a 4-quinolylacetic acid fungicide, an inorganic compound, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof; The ratio of prothioconazole to the second fungicide is 1:15 to 15:1.

[0099] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) a second fungicide selected from the group consisting of a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, an inorganic compound, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof; The ratio of prothioconazole to the second fungicide is 1:10 to 10:1.

[0100] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) a triazole fungicide; and (ii) at least one quinone external inhibitor (QoI) fungicide; The ratio of triazole fungicide to quinone external inhibitor (QoI) fungicide is 1:15 to 15:1.

[0101] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) a triazole fungicide; and (ii) at least one quinone external inhibitor (QoI) fungicide; The ratio of triazole fungicide to quinone external inhibitor (QoI) fungicide is 1:10 to 10:1.

[0102] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) at least one quinone external inhibitor (QoI) fungicide comprising a strobilurin fungicide, wherein the ratio of prothioconazole to quinone external inhibitor (QoI) fungicide is from 1:15 to 15:1.

[0103] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) a quinone external inhibitor (QoI) fungicide, including a strobilurin fungicide, wherein the ratio of prothioconazole to the quinone external inhibitor (QoI) fungicide is from 1:10 to 10:1.

[0104] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) at least one strobilurin fungicide; The ratio of prothioconazole to strobilurin fungicide is 1:15 to 15:1.

[0105] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) at least one strobilurin fungicide; The ratio of prothioconazole to strobilurin fungicide is 1:10 to 10:1.

[0106] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) azoxystrobin, The ratio of prothioconazole to azoxystrobin is 1:15 to 15:1.

[0107] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) azoxystrobin, The ratio of prothioconazole to azoxystrobin is 1:10 to 10:1.

[0108] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) picoxystrobin, The ratio of prothioconazole to picoxystrobin was 1:15 to 15:1.

[0109] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) picoxystrobin, The ratio of prothioconazole to picoxystrobin is 1:10 to 10:1.

[0110] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) trifloxystrobin, The ratio of prothioconazole to trifloxystrobin is 1:15 to 15:1.

[0111] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) trifloxystrobin, The ratio of prothioconazole to trifloxystrobin is 1:10 to 10:1.

[0112] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) fluoxastrobin, The ratio of prothioconazole to fluoxastrobin is 1:15 to 15:1.

[0113] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) fluoxastrobin, The ratio of prothioconazole to fluoxastrobin is 1:10 to 10:1.

[0114] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) 4-quinolyl acetic acid fungicide, The ratio of prothioconazole to 4-quinolyl acetate fungicide is 1:15 to 15:1.

[0115] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) tebufloquine, The ratio of prothioconazole to tebufloquine is 1:15 to 15:1.

[0116] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) tebufloquine, The ratio of prothioconazole to tebufloquine is 1:10 to 10:1.

[0117] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) kasugamycin, The ratio of prothioconazole to kasugamycin is 1:15 to 15:1.

[0118] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) kasugamycin, The ratio of prothioconazole to kasugamycin is 1:10 to 10:1.

[0119] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) a dithiolane fungicide; The ratio of prothioconazole to dithiolane fungicide is 1:15 to 15:1.

[0120] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) isoprothiolane, The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0121] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) isoprothiolane, The ratio of prothioconazole to isoprothiolane is 1:10 to 10:1.

[0122] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) an inorganic compound; The ratio of prothioconazole to inorganic compounds is 1:15 to 15:1.

[0123] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) an inorganic compound; The ratio of prothioconazole to inorganic compounds is 1:10 to 10:1.

[0124] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) sulfur, The ratio of prothioconazole to sulfur is 1:15 to 15:1.

[0125] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole, (ii) sulfur, The ratio of prothioconazole to sulfur is 1:10 to 10:1.

[0126] Rice blast in the present invention refers to a crop disease caused by the rice blast fungus Magnaporthe oryzae (synonym: Magnaporthe grisea) in rice cultivation, which causes severe damage to rice leaves (leaf blast) and panicles (panicle blast or panicle neck blast). Furthermore, all parts of the panicle, i.e. spikelets, glumes, branches, rachis, and panicle neck, are susceptible to blast, and especially damage to the panicle neck (panicle neck blast) leads to complete loss of the panicle neck.

[0127] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) a triazole fungicide; and (ii) at least one fungicide; The ratio of the triazole fungicide to the second fungicide is 1:15 to 15:1.

[0128] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) a triazole fungicide, including prothioconazole; (ii) a second fungicide selected from the group consisting of a quinone external inhibitor (QoI) fungicide, an inorganic compound, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, an inorganic compound, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof; The ratio of prothioconazole to the second fungicide is 1:15 to 15:1.

[0129] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) a quinone external inhibitor (QoI) fungicide, including a strobilurin fungicide, wherein the ratio of prothioconazole to quinone external inhibitor (QoI) fungicide is from 1:15 to 15:1.

[0130] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) azoxystrobin, The ratio of prothioconazole to azoxystrobin is 1:15 to 15:1.

[0131] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) picoxystrobin, The ratio of prothioconazole to picoxystrobin was 1:15 to 15:1.

[0132] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) trifloxystrobin, The ratio of prothioconazole to trifloxystrobin is 1:15 to 15:1.

[0133] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) fluoxastrobin, The ratio of prothioconazole to fluoxastrobin is 1:15 to 15:1.

[0134] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) tebufloquine, The ratio of prothioconazole to tebufloquine is 1:15 to 15:1.

[0135] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) kasugamycin, The ratio of prothioconazole to kasugamycin is 1:15 to 15:1.

[0136] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) isoprothiolane, The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0137] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) an inorganic compound; The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0138] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) sulfur, The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0139] In one embodiment, the present invention provides a fungicide combination for controlling the rice blast fungus, Magnaporthe grisea, in rice cultivation, the combination comprising: (i) prothioconazole, (ii) a copper salt; The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0140] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) a demethylation inhibitor fungicide in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0141] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) a triazole fungicide in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0142] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0143] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) at least one strobilurin fungicide in an amount of 10 to 300 g / ha.

[0144] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) azoxystrobin in an amount of 10 to 300 g / ha.

[0145] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) picoxystrobin in an amount of 10 to 300 g / ha.

[0146] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) trifloxystrobin in an amount of 10 to 300 g / ha.

[0147] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) fluoxastrobin in an amount of 10 to 300 g / ha.

[0148] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) tebufloquine in an amount of 10 to 300 g / ha.

[0149] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) kasugamycin in an amount of 10 to 300 g / ha.

[0150] In one embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) isoprothiolane in an amount of 10 to 300 g / ha.

[0151] In one embodiment, the combination of the present disclosure includes at least a third additional fungicide or herbicide or insecticide.

[0152] In one embodiment, the combination of the present disclosure includes at least an additional fungicide.

[0153] In one embodiment, the systemic fungicide may be a single fungicide or may be a combination of one or more systemic fungicides.

[0154] In one embodiment the systemic fungicide is a combination of at least two fungicides.

[0155] In one embodiment, the systemic fungicide in the fungicide combination is selected from a nucleic acid synthesis inhibitor, a cytoskeletal and motor protein inhibitor, an amino acid and protein synthesis inhibitor, a respiratory process inhibitor, a signal transduction inhibitor, a lipid synthesis and membrane integrity disruptor, a sterol biosynthesis inhibitor, a melanin synthesis inhibitor, a cell wall biosynthesis inhibitor, a melanin synthesis inhibitor in the cell wall, a host plant defense inducer, a fungicide with an unknown mechanism of action, an unclassified fungicide, or a biologic with multiple mechanisms of action.

[0156] In a preferred embodiment, the present invention provides a fungicide combination for controlling rice blast in rice cultivation, the combination comprising: (i) a triazole fungicide, including prothioconazole; (ii) a second fungicide comprising a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, an inorganic compound, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof; and (iii) a third fungicide, which comprises a multi-site fungicide.

[0157] In one embodiment the third fungicide, which comprises a contact-active multi-site fungicide, is selected from inorganic compounds, dithiocarbamates, phthalimides, chloronitriles, sulfamides, bisguanidines, triazines, quinones, quinoxalines, maleimides and thiocarbamates.

[0158] In one embodiment, the multi-site fungicides include copper and its salts, sulfur, amovam, ferbam, mancozeb, maneb, metiram, propineb, thiram, zinc, thiazole, zineb, ziram, captan, captafol, folpet, chlorothalonil, dichlofluanid, tolylfluanid, guazatine, iminoctadine, anilazine, dithianone, dithianone, fluoroimide, and metasulfocarb.

[0159] In one embodiment, the copper salt is selected from the group including copper sulfate, dibasic copper sulfate, tribasic copper sulfate, and copper oxychloride.

[0160] The active substances of the combination of the present invention may be applied simultaneously as a tank mix, or sequentially or as a formulation. Application to the soil before plant emergence may be carried out either before or after planting. Application may be carried out as a foliar spray at different times during crop development, with one or two applications early or late after emergence. More preferably, the combination of the present invention is applied to plant propagation material.

[0161] In some embodiments, a combination according to the present disclosure is used to treat plant propagation material.

[0162] In some embodiments, the combinations according to the present disclosure are used in the treatment of seeds, which are a type of plant propagation material.

[0163] The combinations of the present disclosure used to treat plant propagation material are effective in protecting the material and / or the plants resulting therefrom during the life cycle during which the target fungi cause damage to the seeds or plants.

[0164] In one embodiment, a combination for use in controlling leaf blast and neck blast of rice plants comprises prothioconazole and another fungicide, the combination having effective disease control in treating rice blast compared to an untreated control.

[0165] The examples presented herein demonstrate the effectiveness of combinations comprising prothioconazole and other fungicides for controlling fungal diseases of rice caused by rice blast, particularly leaf blast and neck blast.

[0166] Furthermore, the combination of the present invention showed no phytotoxicity towards crop plants.

[0167] The inventive combinations described herein may be formulated in the form of a composition.

[0168] In one embodiment, the present invention provides a composition comprising a combination as described above in any aspect or embodiment and at least one pesticidally acceptable excipient.

[0169] In one embodiment, the present invention provides a fungicidal composition for effectively controlling rice blast, the composition comprising: (i) a demethylation inhibitor fungicide; and (ii) at least one other fungicide comprising a succinate dehydrogenase inhibitor fungicide, a quinone external inhibitor fungicide, a quinone internal inhibitor fungicide, an inorganic compound, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic, a dithiolane fungicide, a dithiocarbamate fungicide; (iii) at least one pesticidally acceptable excipient.

[0170] In a preferred embodiment, the demethylation inhibitor fungicide is preferably a triazole fungicide.

[0171] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) a triazole fungicide; and (ii) at least one fungicide selected from a succinate dehydrogenase inhibitor fungicide, a quinone external inhibitor (QoI) fungicide, a quinone internal inhibitor (QiI) fungicide, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic, a dithiolane fungicide, or a dithiocarbamate fungicide; (iii) at least one agriculturally acceptable excipient.

[0172] In one embodiment the triazole fungicide is prothioconazole, 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-2,4-dihydro-[1,2,4-]-trazol-3-thione or a salt, ester, metabolite, or isomer or derivative thereof.

[0173] Thus, in one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) at least one fungicide selected from a succinate dehydrogenase inhibitor fungicide, a quinone external inhibitor (QoI) fungicide, a quinone internal inhibitor (QII) inhibitor, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic, a dithiolane fungicide, or a dithiocarbamate fungicide; (iii) at least one pesticidally acceptable excipient.

[0174] In one embodiment, prothioconazole is applied at a rate of about 100-500 g ai / ha.

[0175] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) a quinone internal inhibitor (QiI) fungicide; and (iii) at least one pesticidally acceptable excipient.

[0176] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) a strobilurin fungicide; and (iii) at least one pesticidally acceptable excipient.

[0177] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) azoxystrobin, (iii) at least one pesticidally acceptable excipient.

[0178] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) picoxystrobin, (iii) at least one pesticidally acceptable excipient.

[0179] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) fluoxastrobin, (iii) at least one pesticidally acceptable excipient.

[0180] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) trifloxystrobin, (iii) at least one pesticidally acceptable excipient.

[0181] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) kasugamycin, (iii) at least one pesticidally acceptable excipient.

[0182] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) tebufloquine, (iii) at least one pesticidally acceptable excipient.

[0183] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) isoprothiolane, (iii) at least one pesticidally acceptable excipient.

[0184] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) an inorganic compound; (iii) at least one pesticidally acceptable excipient.

[0185] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) a copper salt; (iii) at least one pesticidally acceptable excipient.

[0186] In one embodiment, the present invention provides a fungicidal composition for controlling rice blast, the composition comprising: (i) prothioconazole, (ii) sulfur; (iii) at least one pesticidally acceptable excipient.

[0187] In one embodiment, the prothioconazole is applied in a pesticidally effective amount.

[0188] In one embodiment, the compositions can be prepared by mixing the active ingredients in the composition with an inert carrier, adding surfactants, other adjuvants and carriers as needed, and formulating into a solid or liquid formulation, including, but not limited to, wettable powders, water dispersible granules (WDG), dusts, soluble (liquid) concentrates, suspension concentrates (SC), oil dispersions (OD), oil-in-water emulsions, water-in-oil emulsions, emulsifiable concentrates, capsule suspensions, ZC formulations, or other known formulation types.

[0189] In one embodiment, prothioconazole is used as a 30% w / v OD formulation.

[0190] In one embodiment, the present invention uses prothioconazole and azoxystrobin as a 40% w / v suspension concentrate.

[0191] In one embodiment, the present invention utilizes prothioconazole and sulfur as a 60%-70% w / v suspension concentrate formulation.

[0192] Depending on the type of formulation, they consist of one or more liquid or solid carriers, where appropriate surfactants (dispersants, protective colloids, emulsifiers, wetting agents, tackifiers, etc.) and, where appropriate, other adjuvants customary for the formulation of crop protection products. Those skilled in the art are well acquainted with the formulation of such formulations. Other adjuvants include organic and inorganic thickeners, bactericides, antifreeze agents, defoamers, colorants, adhesives for seed formulations, etc.

[0193] Suitable carriers include liquid carriers and solid carriers. Examples of solid carriers used in formulation include fine powders or granules of minerals such as kaolin clay, attapulgite clay, bentonite, montmorillonite, acid clay, pyrophyllite, talc, diatomaceous earth, and calcite, natural organic substances such as corn cob powder and walnut shell powder, synthetic organic substances such as urea, salts such as calcium carbonate and ammonium sulfate, and synthetic inorganic substances such as synthetic hydrated silicon oxide. Examples of liquid carriers include aromatic hydrocarbons such as xylene, alkylbenzene, and methylnaphthalene, alcohols such as 2-propanol, ethylene glycol, propylene glycol, and ethylene glycol monoethyl ether, ketones such as acetone, cyclohexanone, and isophorone, vegetable oils such as soybean oil and cottonseed oil, petroleum-based aliphatic hydrocarbons, esters, dimethyl sulfoxide, acetonitrile, and water.

[0194] Typically, the combination / composition of the present invention is useful for controlling the phytopathogenic fungus Pyricularia oryzae in rice. Preferably, the present invention is provided for preventing and controlling rice blast, mainly, the present invention is provided for controlling rice leaf blast and / or rice ear blast by applying the combination / composition of the present invention comprising prothioconazole.

[0195] In one embodiment, the present invention provides the use of a fungicide combination comprising a demethylation inhibitor fungicide and at least one fungicide for controlling rice blast, particularly caused by Magnaporthe grisea.

[0196] In one embodiment, the present invention provides the use of a fungicide combination comprising a triazole fungicide and at least one fungicide for controlling rice blast, particularly caused by Magnaporthe grisea.

[0197] In one embodiment, the present invention provides for the use of a fungicide combination comprising a triazole fungicide and at least one fungicide selected from the group consisting of a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, an inorganic compound, a 4-quinolylacetate fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof, for the control of rice blast, particularly caused by Magnaporthe grisea.

[0198] In one embodiment, the present invention provides the use of a fungicide combination comprising a triazole fungicide and a quinone external inhibitor (QoI) fungicide, including a strobilurin fungicide, for controlling rice blast, particularly that caused by Magnaporthe grisea.

[0199] In one embodiment, the present invention provides for the use of a fungicide combination comprising prothioconazole and at least one fungicide selected from the group consisting of quinone external inhibitor (QoI) fungicides, succinate dehydrogenase inhibitor (SDHI) fungicides, quinone internal inhibitor (QiI) fungicides, inorganic compounds, 4-quinolylacetic acid fungicides, hexopyranosyl antibiotic fungicides, and dithiolane fungicides, or combinations thereof, in the control of rice blast, particularly caused by Magnaporthe grisea.

[0200] In one embodiment, the present invention provides the use of a fungicide combination comprising prothioconazole and azoxystrobin in the control of rice blast, particularly that caused by Magnaporthe grisea.

[0201] In one embodiment, the present invention provides the use of a fungicide combination comprising prothioconazole and picoxystrobin in the control of rice blast, particularly that caused by Magnaporthe grisea.

[0202] In one embodiment, the present invention provides the use of a fungicide combination comprising prothioconazole and fluoxastrobin in the control of rice blast, particularly that caused by Magnaporthe grisea.

[0203] In one embodiment, the present invention provides the use of a fungicide combination comprising prothioconazole and trifloxystrobin in the control of rice blast, particularly that caused by Magnaporthe grisea.

[0204] In one embodiment, the present invention provides the use of a fungicide combination comprising prothioconazole and isoprothiolane, particularly in the control of rice blast caused by Magnaporthe grisea.

[0205] In one embodiment, the present invention provides the use of a fungicide combination comprising prothioconazole and tebufloquine, particularly in the control of rice blast caused by Magnaporthe grisea.

[0206] In one embodiment, the present invention provides the use of a fungicide combination comprising prothioconazole and kasugamycin, particularly in the control of rice blast caused by Magnaporthe grisea.

[0207] In one embodiment, the present invention provides the use of a fungicide combination comprising prothioconazole and an inorganic compound, particularly in the control of rice blast caused by Magnaporthe grisea.

[0208] In one embodiment, the present invention provides the use of a combination of prothioconazole and a sulphur-containing fungicide for controlling rice blast, particularly that caused by Magnaporthe grisea.

[0209] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) a demethylation inhibitor fungicide; and (ii) at least one fungicide; The ratio of the demethylation inhibitor fungicide to the second fungicide is 1:15 to 15:1.

[0210] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) a triazole fungicide; and (ii) at least one fungicide; The ratio of the triazole fungicide to the second fungicide is 1:15 to 15:1.

[0211] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) a triazole fungicide; and (ii) a second fungicide selected from the group consisting of a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, an inorganic compound, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof; The ratio of prothioconazole to the second fungicide is 1:15 to 15:1.

[0212] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) a second fungicide selected from the group consisting of a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, an inorganic compound, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof; The ratio of prothioconazole to the second fungicide is 1:15 to 15:1.

[0213] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) a triazole fungicide; and (ii) at least a quinone external inhibitor (QoI) fungicide; The ratio of triazole fungicide to quinone external inhibitor (QoI) fungicide is 1:15 to 15:1.

[0214] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) at least one quinone external inhibitor (QoI) fungicide; The ratio of triazole fungicide to quinone external inhibitor (QoI) fungicide is 1:15 to 15:1.

[0215] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) at least one strobilurin fungicide; The ratio of prothioconazole to strobilurin fungicide is 1:15 to 15:1.

[0216] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) azoxystrobin, The ratio of prothioconazole to azoxystrobin is 1:15 to 15:1.

[0217] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) picoxystrobin, The ratio of prothioconazole to picoxystrobin was 1:15 to 15:1.

[0218] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) trifloxystrobin, The ratio of prothioconazole to trifloxystrobin is 1:15 to 15:1.

[0219] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) fluoxastrobin, The ratio of prothioconazole to fluoxastrobin is 1:15 to 15:1.

[0220] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) tebufloquine, The ratio of prothioconazole to tebufloquine is 1:15 to 15:1.

[0221] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) kasugamycin, The ratio of prothioconazole to kasugamycin is 1:15 to 15:1.

[0222] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) isoprothiolane, The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0223] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole, (ii) sulfur, The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0224] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) a demethylation inhibitor fungicide in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0225] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) a triazole fungicide in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0226] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0227] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) at least one strobilurin fungicide in an amount of 10 to 300 g / ha.

[0228] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) azoxystrobin in an amount of 10 to 300 g / ha.

[0229] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) picoxystrobin in an amount of 10 to 300 g / ha.

[0230] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) trifloxystrobin in an amount of 10 to 300 g / ha.

[0231] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) fluoxastrobin in an amount of 10 to 300 g / ha.

[0232] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) tebufloquine in an amount of 10 to 300 g / ha.

[0233] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) an amount of prothioconazole in the range of 50 to 500 g / ha; (ii) kasugamycin in an amount of 10 to 300 g / ha.

[0234] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) isoprothiolane in an amount of 10 to 300 g / ha.

[0235] In one embodiment the present invention provides the use of a combination of fungicides to control rice blast comprising applying a combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) sulfur in an amount of 10 to 300 g / ha.

[0236] In a preferred embodiment, the present invention provides the use of a composition / combination comprising a fungicidally effective amount of prothioconazole and another fungicide in the control of rice leaf blast, as demonstrated in the examples.

[0237] In a preferred embodiment, the present invention provides the use of a composition / combination comprising a fungicidally effective amount of prothioconazole and another fungicide in the control of rice neck blast, as demonstrated in the examples.

[0238] In one embodiment, the present invention provides for the use of a fungicidal composition comprising at least one fungicide selected from the group comprising triazole fungicides, quinone external inhibitor (QoI) fungicides, succinate dehydrogenase inhibitor (SDHI) fungicides, quinone internal inhibitor (QiI) fungicides, 4-quinolylacetic acid fungicides, hexopyranosyl antibiotic fungicides, and dithiolane fungicides or combinations thereof, and an agriculturally acceptable excipient, particularly in the control of rice blast caused by Magnaporthe grisea.

[0239] In one embodiment, the present invention provides the use of a fungicidal composition comprising a triazole fungicide, a quinone external inhibitor (QoI) fungicide including a strobilurin fungicide, and an agriculturally acceptable excipient, in the control of rice blast, particularly caused by Magnaporthe grisea.

[0240] In one embodiment, the present invention provides the use of a fungicidal composition comprising prothioconazole, azoxystrobin and an agriculturally acceptable excipient in the control of rice blast, particularly caused by Magnaporthe grisea.

[0241] In one embodiment, the present invention provides the use of a fungicidal composition comprising prothioconazole, picoxystrobin and an agriculturally acceptable excipient in the control of rice blast, particularly caused by Magnaporthe grisea.

[0242] In one embodiment, the present invention provides the use of a fungicidal composition comprising prothioconazole, fluoxastrobin and an agriculturally acceptable excipient in the control of rice blast, particularly caused by Magnaporthe grisea.

[0243] In one embodiment, the present invention provides the use of a fungicidal composition comprising prothioconazole, trifloxystrobin and an agriculturally acceptable excipient in the control of rice blast, particularly caused by Magnaporthe grisea.

[0244] In one embodiment, the present invention provides the use of a fungicidal composition comprising prothioconazole, isoprothiolane and an agriculturally acceptable excipient in the control of rice blast, particularly caused by Magnaporthe grisea.

[0245] In one embodiment, the present invention provides the use of a fungicidal composition comprising prothioconazole, tebufloquine and an agriculturally acceptable excipient in the control of rice blast, particularly caused by Magnaporthe grisea.

[0246] In one embodiment, the present invention provides the use of a fungicidal composition comprising prothioconazole, kasugamycin and an agriculturally acceptable excipient in the control of rice blast, particularly caused by Magnaporthe grisea.

[0247] In one embodiment, the present invention provides the use of a fungicidal composition comprising prothioconazole, sulphur and an agriculturally acceptable excipient in the control of rice blast, particularly caused by Magnaporthe grisea.

[0248] The present invention further relates to a method for therapeutically controlling, partially or completely, a disease, condition, symptom or adverse effect associated with the occurrence of rice blast caused by Magnaporthe grisea.

[0249] Typically, the present invention provides a method for preventing or controlling phytopathogenic fungi in rice, the method comprising applying a combination / composition of the present invention to a rice plant, plant part, or plant propagation material, or to the locus thereof, in a fungicidally effective amount against the target disease.

[0250] Thus, the present invention provides a method for effectively controlling rice blast, particularly rice leaf blast and rice neck blast, by applying a tank mix of the combinations disclosed herein, or a composition comprising a prothioconazole combination, to rice plants, plant parts, or plant propagation material, or to the locus thereof.

[0251] In one embodiment, a method for controlling rice blast comprises applying to a plant, plant part, plant propagation material, or a locus thereof a fungicide combination of the present invention comprising a) a demethylation inhibitor fungicide, and b) at least one fungicide selected from a succinate dehydrogenase inhibitor fungicide, a quinone external inhibitor fungicide, a quinone internal inhibitor fungicide, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof.

[0252] Preferred demethylation inhibitor fungicides are triazole fungicides.

[0253] A preferred demethylation inhibitor fungicide is prothioconazole.

[0254] In one embodiment, the method of the invention for controlling rice blast fungus in rice comprises applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicidally effective amount of a combination / composition comprising prothioconazole and at least one fungicide selected from a succinate dehydrogenase inhibitor fungicide or a quinone external inhibitor fungicide or a quinone internal inhibitor fungicide, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or combinations thereof, as described herein.

[0255] In one embodiment the method of the invention controls rice blast, in particular rice leaf blast or rice neck blast, by applying to the plant a combination of the invention comprising prothioconazole.

[0256] For use in accordance with the methods of the present invention, compositions containing the prothioconazole combinations described herein will generally contain from 0.01 to 95%, preferably from 0.1 to 90%, and most preferably from 0.5 to 50% by weight of active material.

[0257] The application rate of the composition according to the invention depends on various factors, such as the subject of treatment (e.g. plants, soil or seeds), the type of treatment (e.g. spraying, dusting or seed dressing), the purpose of the treatment (e.g. preventive or therapeutic disease control), and in the case of disease control, the type of fungus to be controlled or the time of application. The amount of the combination of the invention to be applied can be easily estimated by a skilled agronomist.

[0258] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) a demethylation inhibitor fungicide; and (ii) at least one fungicide; The ratio of the demethylation inhibitor fungicide to the second fungicide is 1:15 to 15:1.

[0259] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) a triazole fungicide; and (ii) at least one fungicide; The ratio of the triazole fungicide to the second fungicide is 1:15 to 15:1.

[0260] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) a triazole fungicide; and (ii) a second fungicide selected from the group consisting of a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof; The ratio of prothioconazole to the second fungicide is 1:15 to 15:1.

[0261] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) a second fungicide selected from the group consisting of a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, an inorganic compound, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof; The ratio of prothioconazole to the second fungicide is 1:15 to 15:1.

[0262] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) a triazole fungicide; and (ii) at least a quinone external inhibitor (QoI) fungicide; The ratio of triazole fungicide to quinone external inhibitor (QoI) fungicide is 1:15 to 15:1.

[0263] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) at least one quinone external inhibitor (QoI) fungicide; The ratio of triazole fungicide to quinone external inhibitor (QoI) fungicide is 1:15 to 15:1.

[0264] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) at least one strobilurin fungicide; The ratio of prothioconazole to strobilurin fungicide is 1:15 to 15:1.

[0265] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) azoxystrobin, The ratio of prothioconazole to azoxystrobin is 1:15 to 15:1.

[0266] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) picoxystrobin, The ratio of prothioconazole to picoxystrobin was 1:15 to 15:1.

[0267] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) trifloxystrobin, The ratio of prothioconazole to trifloxystrobin is 1:15 to 15:1.

[0268] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) fluoxastrobin, The ratio of prothioconazole to fluoxastrobin is 1:15 to 15:1.

[0269] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) tebufloquine, The ratio of prothioconazole to tebufloquine is 1:15 to 15:1.

[0270] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) kasugamycin, The ratio of prothioconazole to kasugamycin is 1:15 to 15:1.

[0271] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) isoprothiolane, The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0272] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) an inorganic compound; The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0273] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) sulfur, The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0274] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) a copper salt; The ratio of prothioconazole to isoprothiolane is 1:15 to 15:1.

[0275] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole, (ii) tribasic copper sulfate, The ratio of lotioconazole to isoprothiolane is 1:15 to 15:1.

[0276] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) a demethylation inhibitor fungicide in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0277] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) a triazole fungicide in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0278] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0279] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) at least one strobilurin fungicide in an amount of 10 to 300 g / ha.

[0280] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) azoxystrobin in an amount of 10 to 300 g / ha.

[0281] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) picoxystrobin in an amount of 10 to 300 g / ha.

[0282] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) trifloxystrobin in an amount of 10 to 300 g / ha.

[0283] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) fluoxastrobin in an amount of 10 to 300 g / ha.

[0284] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) tebufloquine in an amount of 10 to 300 g / ha.

[0285] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) kasugamycin in an amount of 10 to 300 g / ha.

[0286] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) isoprothiolane in an amount of 10 to 300 g / ha.

[0287] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) inorganic compounds in an amount of 10 to 300 g / ha.

[0288] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) sulfur in an amount of 10 to 300 g / ha.

[0289] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) a copper salt in an amount of 10 to 300 g / ha.

[0290] In some embodiments, the combination and composition of the present invention can be used in the form of tank-mixed or premixed formulations.The concentration of active substance in ready-to-use, premixed or tank-mixed formulations can vary within a relatively wide range.In addition, it can be applied both before and after plant infection.

[0291] In one embodiment, the active compounds / ingredients of the composition are tank mixed and sprayed onto the site of infection, or alternatively may be mixed with a surfactant and then sprayed.

[0292] In one embodiment, the components of the composition may be used for foliar application, soil application, or application to plant propagation material.

[0293] In one embodiment, the formulation of prothioconazole may be applied to affected plants in an amount of about 0.5 L / Ha to about 5.0 L / Ha, preferably about 1.0 L / Ha to about 2.0 L / Ha, and more preferably about 1.0 L / Ha to about 1.5 L / Ha.

[0294] In one embodiment, the invention provides a method for controlling phytopathogenic fungi that cause rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicide combination, the fungicide combination comprising: (i) a triazole fungicide in an amount of 50 to 500 g / ha; (ii) at least one fungicide in an amount of 10 to 300 g / ha.

[0295] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast disease, the method comprising applying a fungicidal composition comprising prothioconazole and at least one fungicide to rice plants, plant parts or plant propagation material, or the locus thereof, in an amount of from 100 to 3000 g / ha.

[0296] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast disease, the method comprising applying to a rice plant, plant part, or plant propagation material, or to the locus thereof, a fungicidal composition comprising prothioconazole and at least one fungicide in an amount of from 200 to 2500 g / ha.

[0297] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast disease, the method comprising applying to a rice plant, plant part or plant propagation material, or the locus thereof, a fungicidal composition comprising prothioconazole and a strobilurin fungicide in an amount of 100 to 3000 g / ha.

[0298] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part or plant propagation material, or the locus thereof, a fungicidal composition comprising prothioconazole and a strobilurin fungicide in an amount of from 200 to 2500 g / ha.

[0299] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or the locus thereof, a fungicidal composition comprising prothioconazole and picoxystrobin in an amount of 100 to 3000 g / ha.

[0300] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and picoxystrobin in an amount of 200-2500 g / ha.

[0301] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or the locus thereof, a fungicidal composition comprising prothioconazole and azoxystrobin in an amount of 100 to 3000 g / ha.

[0302] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and azoxystrobin in an amount of 200-2500 g / ha.

[0303] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, or plant propagation material, or the locus thereof, a fungicidal composition comprising prothioconazole and trifloxystrobin in an amount of 100 to 3000 g / ha.

[0304] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast disease, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and trifloxystrobin in an amount of 200-2500 g / ha.

[0305] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and fluoxastrobin in an amount of 100 to 3000 g / ha.

[0306] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and fluoxastrobin in an amount of 200-2500 g / ha.

[0307] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and tebufloquine in an amount of 100 to 3000 g / ha.

[0308] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast disease, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and tebufloquine in an amount of from 200 to 2500 g / ha.

[0309] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast disease, the method comprising applying to a rice plant, plant part, or plant propagation material, or the locus thereof, a fungicidal composition comprising prothioconazole and kasugamycin in an amount of 100-3000 g / ha.

[0310] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast disease, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and kasugamycin in an amount of 200-2500 g / ha.

[0311] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast disease, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and isoprothiolane in an amount of from 100 to 3000 g / ha.

[0312] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and isoprothiolane in an amount of from 200 to 2500 g / ha.

[0313] In one embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and sulfur in an amount of from 100 to 3000 g / ha.

[0314] In a preferred embodiment, the present invention provides a method for controlling phytopathogenic fungi causing rice blast disease, the method comprising applying to a rice plant, plant part, plant propagation material, or the locus thereof a fungicidal composition comprising prothioconazole and sulfur in an amount of from 200 to 2500 g / ha.

[0315] The compositions containing the prothioconazole combinations described herein may be applied directly by means such as spraying, atomizing, dusting, painting, brushing, dipping or pouring.

[0316] The composition of the present invention may further comprise fertilizers such as ammonium nitrate, urea, potash, superphosphate, phytotoxic substances, plant growth regulators, and safeners. These may be used sequentially or in combination with the above compositions, and may be added only immediately before use (tank mix) if appropriate. For example, the plant(s) may be sprayed with the composition of the present invention before or after being treated with fertilizer.

[0317] In some embodiments, the compositions of the present invention may be applied sequentially or simultaneously in any desired order or in any combination. The application rate of the total amount of the fungicidally active composition including the combination of prothioconazole may be any rate suitable for treating the target plant.

[0318] In one embodiment, the method of the present invention provides effective control of fungal pathogens and can be applied before or after fungal disease emergence, thereby providing resistance management and complete control of fungal pathogens. Furthermore, the current combinations are not phytotoxic to plants.

[0319] The present invention also provides a kit comprising a prothioconazole combination and instructions for use for controlling rice blast fungus in rice. The kit comprising the prothioconazole combination described herein is highly useful for controlling rice blast, particularly rice leaf blast and rice ear blast. The instructions typically include instructions for applying the prothioconazole combination of the present invention to a target site.

[0320] In one embodiment, the kit comprises: i) a first component comprising prothioconazole; ii) a second component comprising a second fungicide selected from the group comprising a quinone external inhibitor (QoI) fungicide, a succinate dehydrogenase inhibitor (SDHI) fungicide, a quinone internal inhibitor (QiI) fungicide, a 4-quinolylacetic acid fungicide, a hexopyranosyl antibiotic fungicide, and a dithiolane fungicide, or a combination thereof.

[0321] Typically, the kit comprises: i) a first component comprising prothioconazole; ii) a second component comprising a second fungicide; and iii) a third component comprising at least one pesticidally acceptable excipient, diluent, adjuvant and / or safener; and, optionally, and iv) instructions for use.

[0322] Typically, the instructions include instructions instructing the user to mix the components of the kit. Usually, the instructions include instructions instructing the user to mix the components of the kit prior to applying the components of the kit to a target site.

[0323] In many cases, the components of the kit are packaged separately. However, the present invention is not limited to kits in which the components are packaged separately. For example, the first component and the second component may be packaged together or formulated together.

[0324] The fungicide combination / composition of the present invention is very safe for crops, can control target fungi in paddy fields, and surprisingly, has a synergistic effect on controlling target fungi in paddy fields. Therefore, the present invention provides the best solution to the problems of rice farmers.

[0325] The present invention will be described in more detail below with reference to examples. The above description of the present invention allows a person skilled in the art to make and use what is currently considered to be the best mode, but the person skilled in the art will understand and recognize the existence of variations, combinations, and equivalents of the specific embodiments, methods, and examples described herein. Therefore, the present invention is not limited to the above-mentioned embodiments, methods, and examples below, but should be limited to all embodiments and methods within the scope and spirit of the present invention. EXAMPLES

[0326] Example 1: Efficacy of combined use of prothioconazole and azoxystrobin in controlling rice leaf blast

[0327] Tests were carried out to confirm the efficacy of the combination of prothioconazole and azoxystrobin against leaf blast in rice crops by foliar spray. The application efficacy of the above fungicide combination according to the invention against leaf blast fungus was demonstrated by the following field test. Evaluation of the control rate of the pathogen in rice crops was carried out using a scale of 0-100% compared to an untreated control rice crop. Applications were carried out in a plot size of 12 m2 (3 m x 4 m).

[0328] In the following experiment, the fungicidal activity of the combination of prothioconazole and azoxystrobin was evaluated. In this test, time T was the application time, A-0 day, i.e., the first application, B was designated as the second application 7 days after application "A" (i.e., 7 DAA), C was designated as the third application 14 days after application "A" (i.e., 14 DAA), and so on. Thus, observations of control rate in rice crops were made at 7 DAA, 14 DAA, 21 DAA, and 28 DAA. Final values ​​reported were the average of four replicates.

[0329] [Table 1(a)]

[0330] [Table 1(b)]

[0331] As can be seen from the data in Table 1(b), the combination of prothioconazole and azoxystrobin showed significantly higher fungicidal efficacy in controlling leaf blast compared to the reference product (tricyclazole).

[0332] Example 2: Efficacy of combined use of prothioconazole and kasugamycin in controlling rice leaf blast

[0333] A trial was carried out to determine whether the combination of prothioconazole and kasugamycin is effective against rice leaf blast. The application efficacy of the above fungicide combination according to the invention against the leaf blast fungus was demonstrated by the following field trial. The trial also included a tricyclazole treatment. The application efficacy of the above fungicide combination according to the invention against the leaf blast fungus (Magnaporthe grisea) was demonstrated by the following field trial. The evaluation of the inhibition rate of the pathogenic leaf blast fungus was carried out using a 0-100% scale compared to untreated control plants. The application was carried out at 12 m 2 The study was carried out on a plot size of (3m x 4m).

[0334] In the following experiment, the fungicidal activity of the combination of prothioconazole and kasugamycin was evaluated. In this test, time T was the application time, A-0 day i.e. the first application, B was designated as the second application 7 days after application “A” (i.e. 7 DAA), C was designated as the third application 14 days after application “A” (i.e. 14 DAA), and so on. Thus, observations of control rate in rice crop were made at 7 DAA, 14 DAA, 21 DAA, and 28 DAA.

[0335] [Table 2(a)]

[0336] [Table 2(b)]

[0337] As can be seen from the data in the table above, the combination of prothioconazole and kasugamycin showed significantly greater effectiveness in controlling leaf blast compared to the reference product (tricyclazole).

[0338] Example 3: Efficacy of Prothioconazole and Qol combination against rice panicle blast fungus

[0339] A test was carried out to determine whether the combination of prothioconazole and kasugamycin is effective against rice ear blast. The application efficacy of the above fungicide combination according to the present invention against rice ear blast was demonstrated by the following field test.

[0340] [Table 3(a)]

[0341] [Table 3(b)]

[0342] The above results indicate that the fungicide combination with prothioconazole is highly effective in controlling rice blast disease, and its efficacy is superior to that of prothioconazole alone.

[0343] Example 4: Efficacy of combination use of prothioconazole against rice panicle blast fungus A study was conducted to determine the efficacy of prothioconazole combination against rice neck blast fungus ( Magnaporthe grisea ).

[0344] [Table 4(a)]

[0345] [Table 4(b)]

[0346] From the above results, the fungicide combination containing prothioconazole exerted superior control effect against rice panicle blast disease compared to the untreated control.

[0347] Example 5: Synergistic control of rice ear blast

[0348] A test was conducted to confirm the synergistic control effect of the combination of prothioconazole against rice ear blast. The application effect of the fungicide combination disclosed in accordance with the present invention against rice ear blast was demonstrated by the following field test.

[0349] A method often used to improve the use profile of a pesticide is to combine the active compound with one or more other active compounds that contribute desirable additional properties. However, when two or more active compounds are used in combination, it is not uncommon to encounter phenomena that result in physical and biological incompatibilities, such as insufficient stability of the combined formulation, degradation of the active compounds, or antagonism of the active compounds. In contrast, what is desired is a combination of active compounds that has a favorable activity profile, high stability, and, if possible, synergistically enhanced activity, thereby allowing the application rate to be reduced compared to the application of the active compounds to be combined individually. Mixtures of chemicals may exert antagonistic effects when mixed, resulting in a lower effect than would be expected when the chemicals are combined. There may also be additive effects, where the resulting mixture gives the results expected from the sum of its components. Finally, synergistic effects may occur, where the results are greater than expected. Synergistic effects are rare and are usually only observed at high concentrations. In the heavily regulated pesticide industry, high concentrations in the environment are undesirable. Thus, if synergistic effects are achieved at low doses, the resulting mixture is indeed a rare and unexpected discovery.

[0350] A synergistic effect of pesticides exists whenever the antiphytopathogenic activity of a combination of active compounds exceeds the sum of the activities of the active compounds applied individually. The expected activity of a particular combination of two active compounds can be calculated according to SR Colby ("Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 15, (1967), 20-22).

[0351] Colby Calculation: For all treatments, treatment efficacy, as measured by the percentage reduction in growth of the target plant pathogen, was evaluated according to Colby's formula:

[0352] Suppose, X is the growth inhibition rate at the application rate of prothioconazole (A), Y is the growth inhibition rate at the application rate of another fungicide selected from strobilurin fungicides and dithiolane fungicides; Expected growth rates when active compounds A and B were applied at rates E relative to controls with prothioconazole and a second fungicide. When Colby's equation is E=X+Y-XY / 100.

[0353] If the actual / observed antiphytopathogenic efficacy of prothioconazole and the second fungicide against blast growth exceeds the calculated value, the activity of the combination is supra-additive, i.e. synergistic effects exist. In this case, the actual observed efficacy must be greater than the expected efficacy (E) value calculated from the above formula.

[0354] [Table 5(a)]

[0355] The combinations of the present invention consisting of prothioconazole and picoxystrobin, and prothioconazole and trifloxystrobin, were synergistic upon application and effectively controlled the rice blast fungus.

[0356] [Table 5(b)]

[0357] The present combination provides a synergistic effect consisting of prothioconazole and isoprothiolane in its application and can effectively control the rice blast fungus as shown in Table 4(b).

[0358] Example 5: Efficacy of a fungicidal composition containing prothioconazole and sulfur against rice leaf blast

[0359] A test was conducted to determine whether the combination of prothioconazole and kasugamycin is effective against rice leaf blast. The effectiveness of the fungicide combination according to the present invention when applied against rice ear blast was demonstrated by the following field test. In the following experiment, the fungicidal activity of a composition comprising a combination of prothioconazole and sulfur was evaluated. Treatments 2, 3, and 4 in Table 6 used suspension concentrate compositions containing 675 g / L, 676 g / L, and 677 g / L of prothioconazole and sulfur, respectively.

[0360] In this test, time T was the application time, A-0 day i.e. the first application, B was designated as the second application 7 days after application "A" (i.e. 7 DAA), C was designated as the third application 14 days after application "A" (i.e. 14 DAA), and so on. Thus, observations of control rate in rice crops were made at 7 DAA, 14 DAA, 21 DAA, and 28 DAA. Final values ​​reported were the average of four replicates.

[0361] [Table 6]

[0362] The composition of the present invention comprising prothioconazole and sulfur effectively controlled the rice blast fungus, as shown in Table 6.

Claims

1. A fungicide combination for controlling rice blast comprising: (i) a demethylation inhibitor fungicide; and (ii) a fungicide(s) selected from a demethylase inhibitor (DMI), a quinone external inhibitor (QOI), a succinate dehydrogenase inhibitor (SDHI), a quinone internal inhibitor (QII), a 4-quinolylacetate fungicide, an inorganic compound, a hexopyranosyl antibiotic fungicide, or a dithiolane fungicide, or a combination thereof; A fungicide combination comprising:

2. The (i) demethylation inhibitor fungicide is, for example, azaconazole, bromuconazole, cyproconazole, diclobutrazol, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluconazole, fluquinconazole, flusilazole, flutriafol, fluconazole, fluconazole-cis, hexaconazole, imibenconazole, ipconazole, ipfentrifluconazole, mefentri 2. The fungicide combination of claim 1, which is a triazole fungicide selected from the group consisting of fluconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, thiabendazole, triadimefon, triadimenol, triticonazole, uniconazole and uniconazole-P, their salts, esters, isomers, derivatives, or combinations thereof.

3. A fungicidal combination according to claim 2, wherein the triazole fungicide is prothioconazole.

4. 2. The fungicidal combination of claim 1, wherein the quinone external inhibitor is selected from strobilurin fungicides including azoxystrobin, coumaxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, trifloxystrobin, dimoxystrobin, phenaminestrobin, metominostrobin, orysastrobin, famoxadone, fluoxastrobin, fenamidone or pyribencarb.

5. 2. The fungicidal combination of claim 1, wherein the succinate dehydrogenase inhibitor (SDHI) is selected from the group consisting of benzovindiflupyr, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid, thifluzamide, carboxin, oxycarboxin, fenfuram, fluopyram, isofetamide, benodanil, flutolanil or mepronil.

6. 2. The fungicide combination of claim 1, wherein the dithiocarbamate fungicide is selected from the group consisting of amovam, asomet, azithiram, carbamorph, kufuraneb, cuprobam, disulfiram, ferbam, metham, nabam, tecoram, thiram, urbicide, ziram, dazomet, ethem, milneb, mancopper, mancozeb, maneb, metiram, polycarbamate, propineb, or zineb.

7. 2. The fungicide combination of claim 1, wherein said QII is selected from the group consisting of cyazofamid, amisulbrom, fenpicoxamid and florylpicoxamid.

8. 2. The fungicidal combination of claim 1, wherein the inorganic compound is a sulfur salt or a copper salt including copper sulfate, copper oxychloride, tribasic copper sulfate.

9. 2. The fungicidal combination of claim 1, wherein the 4-quinolyl acetate fungicide is tebufloquine.

10. 2. The fungicidal combination of claim 1, wherein said hexopyranosyl antibiotic fungicide is kasugamycin.

11. 2. The fungicide combination of claim 1, wherein the dithiolane fungicide is isoprothiolane.

12. (i) prothioconazole, (ii) a fungicide selected from the group consisting of azoxystrobin, picoxystrobin, trifloxystrobin, fluoxastrobin, tebufloquine, kasugamycin, isoprothiolane, and sulfur; 2. The fungicidal combination of claim 1 comprising:

13. 2. The fungicidal combination of claim 1, wherein the combination comprises a ratio of demethylation inhibitor fungicide to one or more fungicides of from 1:15 to 15:

1.

14. 2. The fungicidal combination of claim 1, wherein the rice blast is caused by Magnaporthe grisea.

15. 2. The fungicide combination of claim 1, wherein the combination further comprises a multi-site or systemic fungicide.

16. A fungicidal composition for controlling rice blast, comprising: A combination according to claim 1; one or more pesticidally acceptable excipients; 1. A fungicidal composition comprising:

17. (i) prothioconazole, (ii) a fungicide selected from the group consisting of azoxystrobin, picoxystrobin, pyraoxystrobin, pyraclostrobin, trifloxystrobin, sulfur, isoprothiolane, tebufloquine, and kasugamycin; (iii) one or more pesticidally acceptable excipients; and 17. The fungicidal composition of claim 16, comprising:

18. 17. A method for controlling rice blast comprising applying to a rice plant, part thereof, or plant propagation material, or the locus thereof, a fungicide combination as defined in claim 1, or a composition as defined in claim 16.

19. In the place of rice plants, (i) prothioconazole in an amount of 50 to 500 g / ha; (ii) at least one fungicide selected from succinate dehydrogenase inhibitor fungicides, quinone external inhibitor fungicides, quinone internal inhibitor fungicides, 4-quinolylacetic acid fungicides, hexopyranosyl antibiotic fungicides, and dithiolane fungicides, or combinations thereof, in an amount of 10 to 300 g / ha; 20. The method of claim 18 comprising applying a fungicide combination comprising:

20. 19. The method of claim 18, comprising applying the fungicidal composition at a rate of from 100 to 3000 g / ha.

21. 1. Use of a fungicide combination comprising prothioconazole and at least one fungicide selected from the group consisting of quinone external inhibitor (Qol) fungicides, succinate dehydrogenase inhibitor (SDHI) fungicides, quinone internal inhibitor (Qol) fungicides, inorganic compounds, 4-quinolylacetic acid fungicides, hexopyranosyl antibiotic fungicides, and dithiolane fungicides, or combinations thereof, in the control of rice blast, particularly rice blast caused by Magnaporthe grisea.

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