Oral care compositions and uses thereof

Abstract

This document provides a method for the preparation of a dental abrasive having a calcium carbonate content of more than 95% (w / w) and between about 2.70 and about 3.1 μM. 2 A treated aragonite calcium carbonate (CaCO) with a specific surface area (SSA) of 100 / g 3 The present invention describes an oral care composition comprising: fluoride-containing aragonite calcium carbonate particles; a fluoride compound suitable for providing beneficial fluoride treatment to teeth; and a suitable carrier. To avoid reaction of fluoride from the fluoride compound with the treated aragonite calcium carbonate particles, the treated aragonite calcium carbonate particles are effectively treated under mildly acidic conditions.

Description

[Technical field]

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority to U.S. Provisional Application No. 63 / 303,186, filed January 26, 2022, the specification of which is incorporated by reference in its entirety. (a) Field The disclosed subject matter relates generally to oral care compositions and uses thereof, and more specifically, the disclosed subject matter relates to oral care compositions comprising cuttlebone powder and uses thereof. [Background technology]

[0002] (b) Related Prior Art Bacterial plaque and calculus are the main etiological factors in the initiation and progression of periodontal disease. Calculus is mineralized plaque and, being porous, can absorb various toxic products, thus serving as an ideal substrate for microbial colonization below the gum line. Calculus should therefore be accurately detected and thoroughly removed for proper periodontal treatment. Many techniques have been used to identify and remove calculus deposits present on the dentin surface. Maintaining proper oral hygiene is one of the most important measures to be undertaken to combat gingivitis. The selection of the correct toothpaste is the first step in the fight against oral diseases. Brushing to efficiently remove plaque is always also a concern for tooth wear and gingival recession. Brushing itself has little abrasive action, and therefore the loss of enamel as a result of brushing is mainly the result of the abrasives used in the toothpaste. On the other hand, much of the cleaning action during brushing is related to the abrasive materials in the toothpaste, and therefore their presence is essential for cleaning. Toothpastes currently available in the market have various types of abrasives in their formulations such as calcite, calcite and aragonite, silicon dioxide, brushite, gibbsite, etc.

[0003] Moreover, toothpastes are generally produced to serve multiple purposes simultaneously and therefore have complex chemical compositions. Ideally, toothpaste formulations should be balanced to minimize abrasive damage to dentin structures while maintaining maximum cleaning benefits. Thus, overly abrasive materials can abrade dentin surfaces, resulting in undesirable tooth wear and sensitivity. Many factors dictate the abrasiveness of a given compound, including its hydration level; the size, hardness, shape, and concentration of particulate components; source; purity; and even the way it has been physically and chemically processed. Toothpastes can also act as vehicles for antimicrobial agents that may have a preventative / therapeutic role in periodontal disease. The complex composition of toothpastes means that it is necessary to ensure that active ingredients are not inactivated during the production or delivery process. For example, calcium carbonate added to dentifrices binds fluoride, rendering it ineffective as an anticaries agent (Shen et al. "Bioavailable fluoride in calcium-containing dentifrices" Scientific Reports, (2021) 11:146). Thus, the composition of toothpastes is important for their effectiveness in maintaining oral health and their safety in the oral cavity.

[0004] In a continuous process of demineralization and remineralization, dentin mineral decreases and increases. Caries (dental decay) is a disease of the dental hard tissues resulting from a time-dependent imbalance in this process, which results in demineralization of the dentin structures by organic acids formed from the interaction between cariogenic bacteria in the dental plaque and fermentable carbohydrates (mainly sugars). The caries process is influenced by the susceptibility of the dentin surface, the bacterial profile, the quantity and quality of saliva, and the presence of fluoride, which promotes remineralization and inhibits demineralization of the dentin structures. Besides the pain resulting from the dentin carious lesion itself, there is also psychological distress from the disease and the possible consequences of medical intervention. Affected teeth cannot always be saved and may need to be extracted. The disease also has significant economic implications, with a significant proportion of the health care budget being spent annually on caries treatment. On a population basis, according to the World Health Organization (WHO), conventional treatment of oral diseases (dental caries and periodontal disease) is the fourth most costly chronic disease to treat.

[0005] Dental caries in permanent teeth is the most prevalent of all conditions assessed in the Global Burden of Disease 2016 study, affecting 2.4 billion people; the estimated prevalence of caries in primary teeth was 486 million children worldwide (GBD 2016). Although there is evidence of a decline in the prevalence and severity of dental caries in some parts of middle- and high-income countries in recent decades, social inequalities in dental health exist, and many individuals and communities bear a significant clinical burden of preventable dental disease. Although caries levels vary considerably between and within countries, children in lower socio-economic background (SES) groups have higher caries levels than children in higher SES groups, and the association between socio-economic status and caries appears to be stronger in high-income countries.

[0006] This paper evaluates the effectiveness of toothpastes containing a specific preparation of processed aragonite calcium carbonate (CaCO3) as an abrasive, which exhibits lower reactivity and interference with fluoride and provides higher bioavailability. Summary of the Invention [Problem to be solved by the invention]

[0007] Against the above background, the present invention offers several advantages and advancements over the prior art. [Means for solving the problem]

[0008] According to one embodiment, there is provided an oral care composition comprising: A calcium carbonate content of more than 95% (w / w) from about 2.70 to about 3.1 m for use as a first dental abrasive. 2 treated aragonitic calcium carbonate (CaCO3) particles with a specific surface area (SSA) of 1 / g; A suitable fluoride compound for providing beneficial fluoride treatment to the teeth; and Suitable carrier wherein the treated aragonite calcium carbonate particles are effectively treated under mildly acidic conditions to avoid reaction of fluoride from the fluoride compound with the treated aragonite calcium carbonate particles.

[0009] The treated aragonite calcium carbonate particles may have a particle size of from about 25 microns to about 70 microns.

[0010] The calcium carbonate content may be from about 95% to about 99.9% (w / w). The particle is about 2.80 m 2 / g~approx. 2.9m 2 / g.

[0011] The particle is about 2.9m 2 / g. The treated aragonite calcium carbonate (CaCO3) particles may be from aragonite of plant origin.

[0012] The aragonite of plant origin may be an oolitic aragonite. The fluoride compound may be sodium fluoride (NaF), stannous fluoride (SnF2), sodium monofluorophosphate (MFP), or a combination thereof.

[0013] The fluoride compound may provide a concentration of from about 800 ppm to about 5000 ppm of fluoride.

[0014] The fluoride compound may provide a concentration of about 1000 ppm to about 1500 ppm of fluoride.

[0015] The treated aragonite calcium carbonate particles may be from about 0.100% to about 20% (w / w) of the composition.

[0016] The particles may have a crystallinity of about 24% to about 28%. The particles may have a crystallinity of about 26%.

[0017] The oral composition may further comprise a second dental abrasive. The second dental abrasive may be colloidal calcium, colloidal silica, hydrous silica, sodium bicarbonate (NaHCO3), aluminum hydroxide (Al(OH)3), calcium carbonate (CaCO3), calcium hydrogen phosphate (CaHPO4·2H2O), anhydrous calcium hydrogen phosphate, silica, zeolite, and hydroxyapatite (Ca5(PO4)3OH), or combinations thereof.

[0018] The second dental abrasive may be sodium bicarbonate (NaHCO3), colloidal silica, or a combination thereof.

[0019] The second dental abrasive may be from about 0.100% to about 30% (w / w) of the composition. The colloidal silica may be from about 0.100% to about 20% (w / w) of the composition.

[0020] Sodium bicarbonate (NaHCO3) may be from about 0.02% to about 0.75% (w / w) of the composition.

[0021] The oral care composition may further comprise a thickening agent. 21. The oral care composition of claim 20, wherein the thickening agent is natural gum obtained from seaweed; natural gum obtained from non-marine plant sources, natural gum produced by bacterial fermentation, starch, pectin, carboxymethylcellulose, hydroxypropylcellulose, methylcellulose, gelatin, silica, or a combination thereof.

[0022] The natural gum obtained from seaweed may be selected from agar (E406), alginic acid (E400), sodium alginate (E401), potassium alginate, ammonium alginate, calcium alginate, carrageenan (E407), or combinations thereof.

[0023] Natural gums obtained from non-marine plant sources may be selected from acacia gum, gum arabic (E414), gum ghatti, gum tragacanth (E413), gum karaya (E416), guar gum (E412), locust bean gum (E410), beta-glucan, chicle gum, dammar gum, glucomannan (E425), mastic gum, psyllium seed husk, spruce gum, tara gum (E417), or combinations thereof.

[0024] The natural gum produced by bacterial fermentation may be selected from gellan gum (E418), xanthan gum (E415), or a combination thereof.

[0025] The thickening agent may comprise from about 0.1% to about 66% (w / w) of the composition. The thickening agent may comprise about 0.5% (w / w) of the composition.

[0026] The oral care composition may further comprise a humectant. Humectants may be propylene glycol, hexylene glycol, butylene glycol, glyceryl triacetate, neoagarobiose, sugar polyols, polymeric polyols, quillaja, lactic acid, urea, glycerin, aloe vera gel, MP diol, alpha hydroxy acids, and honey.

[0027] The sugar polyol may be selected from glycerol, sorbitol, xylitol, maltitol, and combinations thereof.

[0028] The polymeric polyol may be polydextrose, polyethylene glycol, polypropylene glycol, poly(tetramethylene ether) glycol, and combinations thereof.

[0029] The alpha hydroxy acid may be lactic acid. The humectant may be glycerol, xylitol, sorbitol, or a combination thereof.

[0030] The humectant may be from about 2% to about 45% (w / w) of the composition. The oral care composition may further comprise an emulsifier.

[0031] The emulsifiers may be lecithin, vegetable pulp powder, sodium citrate and citric acid, or combinations thereof.

[0032] The vegetable pulp powder may be selected from citrus pulp powder, baobab pulp powder, mango pulp powder, tomato pulp powder, pumpkin pulp powder, guava pulp powder, papaya pulp powder and beet pulp powder, or combinations thereof.

[0033] The sodium citrate may be trisodium citrate. The emulsifier may be from about 1% to about 10% (w / w) of the composition.

[0034] The oral composition may further comprise a surfactant. The surfactant may be selected from sodium lauryl sulfate, ammonium lauryl sulfate, sodium N-lauryl sarcosinate, sodium lauryl sulfoacetate, or combinations thereof.

[0035] The surfactant may be from about 0.5% to about 3% (w / w) of the composition. The oral composition may further include a pH adjusting agent.

[0036] The pH adjusting agent may be selected from citric acid and its derivatives, phosphoric acid and its derivatives, trisodium phosphate, sodium citrate, lactic acid, bicarbonate, or combinations thereof.

[0037] The pH adjuster may be from about 0.1% to about 0.75% (w / w) of the composition. The oral composition may further comprise a preservative.

[0038] The preservative may be selected from sorbitan sesquioleate derivatives, sodium benzoate, benzoic acid, eucalyptus extract, potassium sorbate, or combinations thereof.

[0039] Preservatives may be from about 0.2% to about 2% (w / w) of the composition. The oral composition may further comprise a solvent.

[0040] The solvent may be selected from water, ethanol, isopropanol, sorbitol and glycerol.

[0041] The solvent may be from about 40% to about 99% (w / w) of the composition. The oral composition may further include an antimicrobial agent.

[0042] The antimicrobial agent may be selected from natural essential oils, antimicrobial phenolic compounds, or combinations thereof.

[0043] Natural essential oils include anise oil, lemon oil, orange oil, oregano, rosemary oil, wintergreen oil, thyme oil, lavender oil, clove oil, hops, tea tree oil, citronella oil, wheat oil, barley oil, lemongrass oil, cedar leaf oil, cedarwood oil, cinnamon oil, fleagrass oil, geranium oil, sandalwood oil, violet oil, cranberry oil, eucalyptus oil, verbena oil, peppermint oil, rubber benzoin, basil oil, fennel oil, fir oil, balsam oil, menthol, ocmea origanum oil, Hydastis carradensis oil, Berberidaceae daceae oil, and thyme oil. oil, Ratanhiae and Curcuma longa oil, sesame oil, macadamia nut oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, coriander oil, thyme oil, pimento berry oil, rose oil, bergamot oil, rosewood oil, chamomile oil, sage oil, clary sage oil, cypress oil, sea fennel oil, frankincense oil, ginger oil, grapefruit oil, jasmine oil, juniper oil, lime oil, mandarin oil, marjoram oil, myrrh oil, neroli oil, patchouli oil, pepper oil, black pepper oil, petitgrain oil, pine oil, rose otto oil, spearmint oil, spikenard oil, vetiver oil, or ylang ylang.

[0044] The antimicrobial phenolic compound may be selected from carvacrol, thymol, eugenol, eucalyptol, menthol, or combinations thereof.

[0045] The antimicrobial agent may be from about 0.01% to about 10% (w / w) of the composition. The oral composition may further comprise a flavoring agent.

[0046] Flavoring agents may include menthol, mint essential oil, or combinations thereof. The treated aragonitic calcium carbonate (CaCO3) particles may be chitin-free.

[0047] Use of the oral composition of the present invention for oral hygiene. According to another embodiment, there is provided a use of the oral composition of the present invention for removing stones, preventing stone formation, or a combination thereof.

[0048] According to another embodiment, there is provided a method of cleaning the oral cavity comprising applying to the oral cavity an oral composition of the present invention.

[0049] According to another embodiment, there is provided a method for preventing the formation of or removing stones in the oral cavity, comprising applying to the oral cavity an oral composition of the present invention.

[0050] According to another embodiment, there is provided an oral composition according to the present invention for use in oral hygiene.

[0051] According to another embodiment, there is provided an oral composition according to the present invention for use in stone removal, for use in the prevention of stone formation, or a combination thereof.

[0052] According to another embodiment, there is provided a method for preparing treated aragonite calcium carbonate (CaCO) particles having reduced or inhibited reaction with fluoride from a fluoride compound suitable for providing beneficial fluoride treatment to teeth, comprising: a) crushing aragonite to obtain coarse aragonite powder; b) sieving the coarse aragonite powder to obtain a first crushed aragonite powder having a particle size of about 60 microns to about 75 microns; c) treating the first ground aragonite with a weak acid at a pH of about 4.5 to 5.5 at a temperature and for a time sufficient to demineralize the first ground aragonite to obtain a demineralized ground aragonite; d) washing the demineralized ground aragonite until a neutral pH is achieved; e) drying the demineralized ground aragonite to obtain a calcium carbonate content of greater than 95% (w / w) and from about 2.70 to about 3.1 m 2 To obtain treated aragonite calcium carbonate (CaCO3) particles having a specific surface area (SSA) of 100 / g. The present invention provides a method comprising:

[0053] The weak acid may be ammonium chloride or ammonium acetate, preferably ammonium chloride.

[0054] The concentration of ammonium chloride is about 0.1 M to about 10 M, preferably 1.87 M (10% w / v).

[0055] Step c) may be at a pH of about 4.5. Step c) may be at a pH of about 4.9. Step c) may be at a pH of about 4.86.

[0056] Step c) may be at a temperature of about 65°C to about 75°C. Step d) may be in distilled water.

[0057] Step e) may be at about 200° C. to about 220° C. Step e) may be at about 200° C.

[0058] Step e) may last from about 30 minutes to about 60 minutes. Step e) may last for about 55 minutes.

[0059] The following terms are defined below: The term "oolitic aragonite" is intended to mean aragonite, a calcium carbonate mineral with an egg-like shape ("oolitic" comes from the ancient Greek ωoν, meaning "egg") and sand grain size. This type or aragonite mineral typically forms in tropical waters by precipitation, sedimentation, and microbial activity, indicating a high-energy environment. Oolitic aragonite forms in turbulent, shallow, warm, high salinity waters. Oolitic aragonite begins to form surrounding a calcium carbonate nucleus such as a mineral mud, shell fragment, or foraminifera. The nucleus is coated with a thin layer of crystalline carbonate to form the surface layer of the oolite. Compared to other types of sand formations associated with weathering and erosion of larger rocks by turbulent waters, oolitic aragonite sand is created by the combination of dissolved calcium carbonate with the surface layer or nucleus of the oolite. Calcium carbonate dissolved in seawater continues to adhere to the surface, and in combination with high water velocities that give it a smooth granular shape, oolites are formed, which are composed of aragonite. Biomineralization involving microbial organic matter may also play an important role in oolite formation.

[0060] The term "reduced reaction rate" is intended to refer to the reaction rate or rate of a chemical reaction, which is the rate at which a chemical reaction occurs, defined as the increase in concentration of the product per unit time and the decrease in concentration of the reactant per unit time. In general, the reaction rate can vary dramatically. In the context of the present invention, the reaction rate is the reaction rate between the fluoride compounds present in the oral care composition of the present invention and the calcium present in the composition in the form of aragonite. Without wishing to be bound by theory, it has been shown that the treated roe-like aragonite particles of the present invention have reduced reaction with fluoride compounds, and therefore, after aging of the oral care composition, the amount of bioavailable fluoride is higher than in the oral care composition with different aragonite particles.

[0061] The features and advantages of the inventive subject matter will become more apparent in light of the following detailed description of selected embodiments, as illustrated in the accompanying drawings. As will be understood, the inventive subject matter disclosed and claimed can be modified in various respects, all without departing from the scope of the claims. Thus, the drawings and description should be regarded as illustrative in nature, and not as restrictive, with the full scope of the inventive subject matter being defined in the claims.

[0062] Further features and advantages of the present disclosure will become apparent from the following detailed description taken in conjunction with the accompanying drawings. [Brief description of the drawings]

[0063] [Figure 1] Particle size measurements for CB, TCB, synthetic calcium carbonate (CaCO3) and treated oolitic aragonite are shown. [Diagram 2] Figure 1 shows FTIR characterization of treated oolitic aragonite vs. treated cuttlebone aragonite (TCB). The spectrum of treated oolitic aragonite shows the absence of the C=O band at 1653 cm-1, which corresponds to chitin. [Diagram 3] XRD characterization of treated oocyte aragonite versus treated cuttlebone aragonite (TCB) is shown. The diffractogram of TCB (right) shows broader band widths, indicating smaller grain size. [Figure 4A] 1 shows a scanning electron micrograph (SEM) of cuttlebone (CB) powder. [Figure 4B] 1 shows an SEM of processed cuttlebone (CB) powder. [Figure 4C] 1 shows an SEM of synthetic calcium carbonate (CaCO3) powder. [Figure 4D] 4A shows an SEM of cuttlebone (CB) powder at higher magnification for the sample shown in FIG. [Figure 4E]4B shows an SEM of treated cuttlebone (TCB) powder at a higher magnification for the sample shown. [Figure 4F] 4C shows an SEM of synthetic calcium carbonate (CaCO3) powder at a higher magnification for the sample shown. [Figure 4G] 1 shows an SEM of treated oolitic aragonite powder of the present invention. [Figure 4H] 4G shows an SEM of the treated oolitic aragonite powder of the present invention at higher magnification. [Figure 4I] 4G shows an SEM of the treated oolitic aragonite powder of the present invention at higher magnification. [Figure 4J] 4G shows an SEM of the treated oolitic aragonite powder of the present invention at higher magnification. [Figure 4K] 1 shows an Energy Dispersive X-ray Spectroscopy (EDX) analysis comparing treated cuttlebone (TCB) powder and treated oocyte aragonite. [Diagram 5] Shown are (top left) SEM of the stone surface before reaction with treated oolitic aragonite; (top right) SEM of the stone surface after reaction with treated oolitic aragonite, and (bottom) EDX analysis comparing the stone before and after treatment with treated oolitic aragonite. [Figure 6] The BET specific surface areas of CB, TCB, synthetic calcium carbonate (CaCO3), and treated oocyte-like aragonite (identified as aragonite) are shown. [Figure 7] The polishing depth of TCB, synthetic calcium carbonate (CaCO3), and treated oolitic aragonite (identified as aragonite) slurries on enamel, dentin, and stone is shown. [Figure 8] The inorganic phase abundances determined in the stone samples are shown: amorphous calcium phosphate (ACP), α-tricalcium phosphate (α-TCP), dicalcium phosphate dihydrate (DCPD, in the form of brushite), hydroxyapatite (HA), and aragonite CaCO3. [Figure 9A]Correlation between the amount of non-apatitic calcium phosphate (CaP) versus apatitic calcium phosphate (CaP) [i.e., the sum of hydroxyapatite (HA) and crystalline hydroxyapatite (CHA)] in stone samples is shown. [Figure 9B] Correlation between the amount of α-TCP vs. DCPD in stone samples is shown. [Figure 9C] Correlation between the amount of α-TCP versus aragonite in stone samples is shown. [Figure 9D] Correlation between DCPD vs. aragonite content in stone samples is shown. [Figure 9E] Correlation between DCPD vs. HA amounts in stone samples is shown. [Figure 9F] Correlation between the amount of α-TCP versus HA in stone samples is shown. [Figure 9G] Correlation between hyaluronan vs. aragonite content in stone samples is shown. [Figure 10A] Shows the reactivity of equimolar ratios of calcite, CaCO3, and brushite, dicalcium phosphate dihydrate (DCPD), in HO (top) and not in HO (bottom), as determined by FTIR analysis. [Figure 10B] The reactivity of an equimolar ratio of TCB and brushite dicalcium phosphate dihydrate (DCPD) in HO (top) or not in HO (bottom) is shown as determined by FTIR analysis. [Figure 10C] The subtraction of measurements from FIG. 10A is shown, which indicates that no reaction has occurred based on the magnitude of the F value. [Figure 10D] The subtraction of measurements from FIG. 10B is shown, which indicates that a reaction is occurring between the two compounds based on the magnitude of the F value. [Figure 10E] Shows the reactivity of equimolar ratios of treated oolitic aragonite (ARG) and brushite dicalcium phosphate dihydrate (DCPD) in HO (top) or not in HO (bottom) as determined by FTIR analysis. [Figure 10F]The reactivity of equimolar calcite, CaCO3, and β-tricalcium phosphate (BTCP) in HO (top) or not in HO (bottom) as determined by FTIR analysis. [Figure 10G] The subtraction of measurements from FIG. 10E is shown, which indicates that a reaction is occurring between the two compounds based on the magnitude of the F value. [Figure 10H] The subtraction of measurements from FIG. 10F is shown, which indicates that only a weak reaction occurs between the two compounds based on the magnitude of the F value. [Figure 10I] Figure 2 shows the reactivity of equimolar ratios of treated oolitic aragonite (ARG) and β-tricalcium phosphate (BTCP) in HO (top) or not in HO (bottom) as determined by FTIR analysis. [Figure 10J] The reactivity of equimolar ratios of TCB and β-tricalcium phosphate (BTCP) in HO (top) or not in HO (bottom) as determined by FTIR analysis is shown. [Figure 10K] The subtraction of measurements from FIG. 10I is shown, which indicates that only a weak reaction occurs between the two compounds based on the magnitude of the F value. [Figure 10L] The subtraction of measurements from FIG. 10J is shown, which indicates that only a weak reaction occurs between the two compounds based on the magnitude of the F value. [Figure 11A] The reactivity of equimolar ratios of treated oolitic aragonite and stones as determined by FTIR analysis in (top) or without (bottom) HO is shown. [Figure 11B] The subtraction of measurements from FIG. 11A is shown, which indicates that a reaction is occurring between the two compounds based on the magnitude of the F value. [Figure 11C] The reactivity of equimolar calcite CaCO3 and stones as determined by FTIR analysis in (top) or without (bottom) HO is shown. [Figure 11D]The subtraction of measurements from FIG. 11C is shown, which indicates no or only a weak reaction between the two compounds based on the magnitude of the F value. [Figure 12A] Figure 1 shows FTIR spectra of calcite, aragonite, and treated aragonite powders before and after incubation in saturated calcium phosphate solution (*:PO4 3- group) for 14 days. [Figure 12B] The calcium ion concentration in the supernatant is shown. [Figure 12C] The phosphorus ion concentration in the supernatant is shown. [Figure 13] This demonstrates the antilithiasis effect of pyrophosphate, which inhibits stone formation by inhibiting calcium phosphate deposition in plaque. [Figure 14] FIG. 2 is a schematic diagram illustrating the reaction between aragonite or treated aragonite and dental tartar according to an embodiment of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0064] It is noted that throughout the accompanying drawings, like features are identified by like reference numerals.

[0065] All publications, patents, and patent applications cited herein are hereby expressly incorporated by reference for all purposes.

[0066] Before describing the invention in detail, certain terms will be defined. As used herein, the singular forms "a," "an," and "the" include plural references unless the context clearly dictates otherwise.

[0067] It is noted that terms such as "preferably," "generally," and "typically" are not used herein to limit the scope of the claimed invention or to imply that a particular feature is critical, essential, or even essential to the structure or function of the claimed invention. Rather, these terms are merely intended to highlight alternative or additional features that may or may not be utilized in particular embodiments of the invention.

[0068] For purposes of describing and defining the present invention, it is noted that the term "substantially" is utilized herein to represent the inherent degree of uncertainty that can be attributed to any quantitative comparison, value, measurement, or other expression. The term "substantially" is also utilized herein to represent the degree to which a quantitative expression may vary from a stated standard without resulting in a change in the basic functionality of the inventive subject matter at issue.

[0069] Calculus is mineralized plaque and is porous, so it can absorb various toxic drugs, food debris, and bacteria that can damage periodontal tissues. Calculus removal is therefore important to maintain proper periodontal health. Therefore, there is considerable interest in developing and implementing approaches that would facilitate the calculus removal process. Currently, the only viable method for removing calculus is mechanical removal by scaling in dental clinics. Toothpastes may contain various abrasives, including calcite, silicon dioxide, brushite, and gibbsite, which are essential for cleaning, however, they may also damage enamel and dentin while removing calculus. Toothpastes contain carboxylates and pyrophosphates, which are used in low concentrations in toothpastes to demineralize calculus, but when used in high concentrations, they may dissolve enamel. Calculus is made of calcium phosphate crystals, which are created when calcium and phosphate combine to form calcium phosphate crystals. Other methods for removing and preventing calculus can be aided by brushing with a pyrophosphate-containing toothpaste, such as Crest® Tartar Protection, which adheres to the tooth surface and prevents amorphous calcium phosphate from crystallizing into hydroxyapatite, thereby preventing calculus crystals from forming or developing. Pyrophosphate works by forming a soluble complex with calcium in plaque to prevent mineral crystal formation (deposition) in the plaque on the teeth (see, e.g., FIG. 13).

[0070] Despite being a low toxicity chelating agent, pyrophosphate, however, may prevent hydroxyapatite from crystallizing in bone and teeth, negatively affecting the equilibrium between demineralization and remineralization at the tooth surface. There is a need for an alternative to currently available commercial toothpastes that removes calculus while preserving the underlying structure of the tooth. Calculus contains organic material (approximately 15%-20%) such as proteins, glycoproteins, lipids, DNA, carbohydrates, and bacteria, as well as microparticles (previously known as microfossils) such as plant opals and starch granules. Calculus is largely inorganic, composed primarily of calcium and phosphorus in the form of minerals such as brushite, whitlockite, octacalcium phosphate, and hydroxyapatite, with low percentages of carbonates, sodium, magnesium, silicon, iron, and fluoride. Calcium carbonate, on the other hand, may occur as two separate minerals: calcite (CaCO3) is a stable form, while aragonite is unstable and may eventually be transformed into calcite with time or heat. Calcite is a mineral with the same chemical composition as aragonite, but with a slightly different crystal structure. Aragonite lacks the rhombohedral cleavage of calcite and typically has needle-like crystals in its crystalline form. Brushite and whitlockite are known to react favorably with aragonite and calcite minerals according to the following formula:

[0071] Reaction of dicalcium phosphate (brushite) with calcium carbonate:

[0072]

number

[0073] Reaction of tricalcium phosphate (whittlockite) with calcium carbonate:

[0074]

number

[0075] Compared to rhombohedral calcite crystals, needle-shaped aragonite crystals may react faster. Thus, the removal of dental calculus may be accelerated by the reaction of aragonite with brushite and whitlockite. The effectiveness of aragonite, especially treated aragonite, as a suitable treatment for calculus removal was investigated in comparison with calcite (CaCO3) found in conventional toothpaste.

[0076] The complex composition of toothpastes indicates that it is necessary to ensure that active ingredients are not inactivated in the production or delivery process. For example, calcium carbonate added to dentifrices binds fluoride, rendering it ineffective as an anticaries agent, which is highly undesirable (Shen et al. "Bioavailable fluoride in calcium-containing dentifrices" Scientific Reports, (2021) 11:146). Thus, the composition of toothpastes is critical to their effectiveness in maintaining oral health and their safety in the oral cavity.

[0077] In an embodiment, an oral care composition is disclosed. The composition of the present invention contains, as a component, a calcium carbonate content of more than 95% (w / w) and about 2.70 to about 3.1 mg / g of calcium carbonate for use as a first dental abrasive. 2 The oral care composition contains treated aragonite calcium carbonate (CaCO3) particles having a specific surface area (SSA) of 1000 / g. The composition of the present invention also contains a suitable fluoride compound to provide beneficial fluoride treatment to teeth. Importantly, the treated aragonite calcium carbonate (CaCO3) particles used in the present invention are effectively treated under mildly acidic conditions to avoid reaction of fluoride from the fluoride compound with the treated aragonite calcium carbonate particles.

[0078] Aragonite is a carbonate mineral and one of two common naturally occurring crystalline forms of calcium carbonate, CaCO3, the other being the mineral calcite. It is formed by biological and physical processes, including precipitation from marine and freshwater environments.

[0079] The crystal lattice of aragonite differs from that of calcite, resulting in a different crystal shape, orthorhombic with needle-like crystals. Repeated twinning results in a pseudohexagonal morphology. Aragonite can be columnar or fibrous, and sometimes in branched stalactite forms called flos-ferri ("iron flowers") from their association with the ores of the Carinthian iron mines.

[0080] Aragonite naturally forms in almost all mollusc exoskeletons and as the calcareous endoskeleton of warm- and cold-water corals (Scleractinia). Several species of the family Serpulidae have aragonite tubes. Mineral deposition in mollusc exoskeletons is highly biologically controlled, so some crystal forms are characteristically different from those of inorganic aragonite. In some molluscs, the entire exoskeleton is aragonite; in others, aragonite forms only a separate part (aragonite + calcite) of the biomineral exoskeleton. Aragonite also forms as inorganic precipitates in oceans and caves, where it is called marine cements and speleothems, respectively. The nacre of some extinct fossil aragonite shells of ammonites forms an iridescent material called ammolite. Ammolite is primarily aragonite with impurities that make it iridescent and valuable as a gemstone.

[0081] According to embodiments, the aragonite calcium carbonate (CaCO3) may be from any suitable source that can provide treated aragonite calcium carbonate (CaCO3) particles. In embodiments, the aragonite calcium carbonate may be from an animal source, such as from a cuttlefish or shellfish source. According to another embodiment, the aragonite calcium carbonate may be from a plant source, such as from an oolite source. In a preferred embodiment, the aragonite calcium carbonate and the treated aragonite calcium carbonate are chitin-free to avoid allergic reactions in individuals who are allergic to chitin. Since chitin is usually present in aragonite sourced from animal sources, aragonite from a plant source, such as from an oolite source, is preferred when it is desired to avoid the presence of chitin.

[0082] The particles of treated aragonite calcium carbonate (CaCO3) used in the present invention have a diameter of about 25 μm to about 70 μm, or about 26 μm to about 70 μm, or about 27 μm to about 70 μm, or about 28 μm to about 70 μm, or about 29 μm to about 70 μm, or about 30 μm to about 70 μm, or about 31 μm to about 70 μm, or about 32 μm to about 70 μm, or about 33 μm to about 70 μm, or about 34 μm to about 70 μm, or about 35 μm to about 70 μm, or about 36 μm to about 70 μm, or about 37 μm to about 70 μm, or about 38 μm to about 70 μm, or about 39 μm to about 70 μm, or about 40 μm to about 70 μm, or about 41 μm to about 70 μm, or about 42 μm to about 70 μm, or about 43 μm to about 70 μm, or about 44 μm to about 70 μm, or about 45 μm to about 70 μm, or about 46 μm to about 70 μm, or about 47 μm to about 70 μm, or about 48 μm to about 70 μm, or about 49 μm to about 70 μm, or about 50 μm to about 70 μm, or about 51 μm to about 70 μm, or about 52 μm to about 70 μm, or about 53 μm to about 70 μm, or about 54 μm to about 70 μm, or about 55 μm to about 70 μm, or about 56 μm to about 70 μm, or about 57 μm to about 70 μm, or about 58 μm to about 70 μm, or about 59 μm to about 70 μm, or about 60 μm to about 70 μm, or about 61 μm to about 70 μm, or about 62 μm to about 70 μm, or about 63 μm to about 70 μm, or about 64 μm to about 70 μm, or about 65 μm to about 70 μm, or about 66 μm to about 70 μm, or about 67 μm to about 70 μm, or about 68 μm to about 70 μm, or about 9 μm to about 70 μm, or about 25 μm to about 69 μm, or about 26 μm to about 69 μm, or about 27 μm to about 69 μm, or about 28 μm to about 69 μm, or about 29 μm to about 69 μm, or about 30 μm to about 69 μm, or about 31 μm to about 69 μm, or about 32 μm to about 69 μm, or about 33 μm to about 69 μm, or about 34 μm to about 69 μm, or about 35 μm to about 69 μm, or about 36 μm to about 69 μm, or about 37 μm to about 69 μm, or about 38 μm to about 69 μm, or about 39 μm to about 69 μm,or about 40 μm to about 69 μm, or about 41 μm to about 69 μm, or about 42 μm to about 69 μm, or about 43 μm to about 69 μm, or about 44 μm to about 69 μm, or about 45 μm to about 69 μm, or about 46 μm to about 69 μm, or about 47 μm to about 69 μm, or about 48 μm to about 69 μm, or about 49 μm to about 69 μm, or about 50 μm to about 69 μm, or about 51 μm to about 69 μm, or about 52 μm to about 69 μm, or about 53 μm to about 69 μm, or about 54 μm to about 69 μm, or about 55 μm m to about 69 μm, or about 56 μm to about 69 μm, or about 57 μm to about 69 μm, or about 58 μm to about 69 μm, or about 59 μm to about 69 μm, or about 60 μm to about 69 μm, or about 61 μm to about 69 μm, or about 62 μm to about 69 μm, or about 63 μm to about 69 μm, or about 64 μm to about 69 μm, or about 65 μm to about 69 μm, or about 66 μm to about 69 μm, or about 67 μm to about 69 μm, or about 68 μm to about 69 μm, or about 25 μm to about 68 μm, or about 26 μm to about 68 μm, or about 27 μm to about 68 μm, or about 28 μm to about 68 μm, or about 29 μm to about 68 μm, or about 30 μm to about 68 μm, or about 31 μm to about 68 μm, or about 32 μm to about 68 μm, or about 33 μm to about 68 μm, or about 34 μm to about 68 μm, or about 35 μm to about 68 μm, or about 36 μm to about 68 μm, or about 37 μm to about 68 μm, or about 38 μm to about 68 μm, or about 39 μm to about 68 μm, or about 40 μm to about 68 μm, or about 41 μm to about 68 μm, or about 42 μm m to about 68 μm, or about 43 μm to about 68 μm, or about 44 μm to about 68 μm, or about 45 μm to about 68 μm, or about 46 μm to about 68 μm, or about 47 μm to about 68 μm, or about 48 μm to about 68 μm, or about 49 μm to about 68 μm, or about 50 μm to about 68 μm, or about 51 μm to about 68 μm, or about 52 μm to about 68 μm, or about 53 μm to about 68 μm, or about 54 μm to about 68 μm, or about 55 μm to about 68 μm, or about 56 μm to about 68 μm, or about 57 μm to about 68 μm,or about 58 μm to about 68 μm, or about 59 μm to about 68 μm, or about 60 μm to about 68 μm, or about 61 μm to about 68 μm, or about 62 μm to about 68 μm, or about 63 μm to about 68 μm, or about 64 μm to about 68 μm, or about 65 μm to about 68 μm, or about 66 μm to about 68 μm, or about 67 μm to about 68 μm, or about 25 μm to about 67 μm, or about 26 μm to about 67 μm, or about 27 μm to about 67 μm, or about 28 μm to about 67 μm, or about 29 μm to about 67 μm, or about 30 μm m to about 67 μm, or about 31 μm to about 67 μm, or about 32 μm to about 67 μm, or about 33 μm to about 67 μm, or about 34 μm to about 67 μm, or about 35 μm to about 67 μm, or about 36 μm to about 67 μm, or about 37 μm to about 67 μm, or about 38 μm to about 67 μm, or about 39 μm to about 67 μm, or about 40 μm to about 67 μm, or about 41 μm to about 67 μm, or about 42 μm to about 67 μm, or about 43 μm to about 67 μm, or about 44 μm to about 67 μm, or about 45 μm to about 67 μm, or about 46 μm to about 67 μm, or about 47 μm to about 67 μm, or about 48 μm to about 67 μm, or about 49 μm to about 67 μm, or about 50 μm to about 67 μm, or about 51 μm to about 67 μm, or about 52 μm to about 67 μm, or about 53 μm to about 67 μm, or about 54 μm to about 67 μm, or about 55 μm to about 67 μm, or about 56 μm to about 67 μm, or about 57 μm to about 67 μm, or about 58 μm to about 67 μm, or about 59 μm to about 67 μm, or about 60 μm to about 67 μm, or about 61 μm m to about 67 μm, or about 62 μm to about 67 μm, or about 63 μm to about 67 μm, or about 64 μm to about 67 μm, or about 65 μm to about 67 μm, or about 66 μm to about 67 μm, or about 25 μm to about 66 μm, or about 26 μm to about 66 μm, or about 27 μm to about 66 μm, or about 28 μm to about 66 μm, or about 29 μm to about 66 μm, or about 30 μm to about 66 μm, or about 31 μm to about 66 μm, or about 32 μm to about 66 μm, or about 33 μm to about 66 μm, or about 34 μm to about 66 μm,or about 35 μm to about 66 μm, or about 36 μm to about 66 μm, or about 37 μm to about 66 μm, or about 38 μm to about 66 μm, or about 39 μm to about 66 μm, or about 40 μm to about 66 μm, or about 41 μm to about 66 μm, or about 42 μm to about 66 μm, or about 43 μm to about 66 μm, or about 44 μm to about 66 μm, or about 45 μm to about 66 μm, or about 46 μm to about 66 μm, or about 47 μm to about 66 μm, or about 48 μm to about 66 μm, or about 49 μm to about 66 μm, or about 50 μm m to about 66 μm, or about 51 μm to about 66 μm, or about 52 μm to about 66 μm, or about 53 μm to about 66 μm, or about 54 μm to about 66 μm, or about 55 μm to about 66 μm, or about 56 μm to about 66 μm, or about 57 μm to about 66 μm, or about 58 μm to about 66 μm, or about 59 μm to about 66 μm, or about 60 μm to about 66 μm, or about 61 μm to about 66 μm, or about 62 μm to about 66 μm, or about 63 μm to about 66 μm, or about 64 μm to about 66 μm, or about 65 μm to about 66 μm, or about 25 μm to about 65 μm, or about 26 μm to about 65 μm, or about 27 μm to about 65 μm, or about 28 μm to about 65 μm, or about 29 μm to about 65 μm, or about 30 μm to about 65 μm, or about 31 μm to about 65 μm, or about 32 μm to about 65 μm, or about 33 μm to about 65 μm, or about 34 μm to about 65 μm, or about 35 μm to about 65 μm, or about 36 μm to about 65 μm, or about 37 μm to about 65 μm, or about 38 μm to about 65 μm, or about 39 μm to about 65 μm, or about 40 μm m to about 65 μm, or about 41 μm to about 65 μm, or about 42 μm to about 65 μm, or about 43 μm to about 65 μm, or about 44 μm to about 65 μm, or about 45 μm to about 65 μm, or about 46 μm to about 65 μm, or about 47 μm to about 65 μm, or about 48 μm to about 65 μm, or about 49 μm to about 65 μm, or about 50 μm to about 65 μm, or about 51 μm to about 65 μm, or about 52 μm to about 65 μm, or about 53 μm to about 65 μm, or about 54 μm to about 65 μm, or about 55 μm to about 65 μm,or about 56 μm to about 65 μm, or about 57 μm to about 65 μm, or about 58 μm to about 65 μm, or about 59 μm to about 65 μm, or about 60 μm to about 65 μm, or about 61 μm to about 65 μm, or about 62 μm to about 65 μm, or about 63 μm to about 65 μm, or about 64 μm to about 65 μm, or about 25 μm to about 64 μm, or about 26 μm to about 64 μm, or about 27 μm to about 64 μm, or about 28 μm to about 64 μm, or about 29 μm to about 64 μm, or about 30 μm to about 64 μm, or about 31 μm m to about 64 μm, or about 32 μm to about 64 μm, or about 33 μm to about 64 μm, or about 34 μm to about 64 μm, or about 35 μm to about 64 μm, or about 36 μm to about 64 μm, or about 37 μm to about 64 μm, or about 38 μm to about 64 μm, or about 39 μm to about 64 μm, or about 40 μm to about 64 μm, or about 41 μm to about 64 μm, or about 42 μm to about 64 μm, or about 43 μm to about 64 μm, or about 44 μm to about 64 μm, or about 45 μm to about 64 μm, or about 46 μm to about 64 μm, or about 47 μm to about 64 μm, or about 48 μm to about 64 μm, or about 49 μm to about 64 μm, or about 50 μm to about 64 μm, or about 51 μm to about 64 μm, or about 52 μm to about 64 μm, or about 53 μm to about 64 μm, or about 54 μm to about 64 μm, or about 55 μm to about 64 μm, or about 56 μm to about 64 μm, or about 57 μm to about 64 μm, or about 58 μm to about 64 μm, or about 59 μm to about 64 μm, or about 60 μm to about 64 μm, or about 61 μm to about 64 μm, or about 62 μm m to about 64 μm, or about 63 μm to about 64 μm, or about 25 μm to about 63 μm, or about 26 μm to about 63 μm, or about 27 μm to about 63 μm, or about 28 μm to about 63 μm, or about 29 μm to about 63 μm, or about 30 μm to about 63 μm, or about 31 μm to about 63 μm, or about 32 μm to about 63 μm, or about 33 μm to about 63 μm, or about 34 μm to about 63 μm, or about 35 μm to about 63 μm, or about 36 μm to about 63 μm, or about 37 μm to about 63 μm, or about 38 μm to about 63 μm,or about 39 μm to about 63 μm, or about 40 μm to about 63 μm, or about 41 μm to about 63 μm, or about 42 μm to about 63 μm, or about 43 μm to about 63 μm, or about 44 μm to about 63 μm, or about 45 μm to about 63 μm, or about 46 μm to about 63 μm, or about 47 μm to about 63 μm,

[0083] or about 48 μm to about 63 μm, or about 49 μm to about 63 μm, or about 50 μm to about 63 μm, or about 51 μm to about 63 μm, or about 52 μm to about 63 μm, or about 53 μm to about 63 μm, or about 54 μm to about 63 μm, or about 55 μm to about 63 μm, or about 56 μm to about 63 μm, or about 57 μm to about 63 μm, or about 58 μm to about 63 μm, or about 59 μm to about 63 μm, or about 60 μm to about 63 μm, or about 61 μm to about 63 μm, or about 62 μm to about 63 μm, or about 25 μm m to about 62 μm, or about 26 μm to about 62 μm, or about 27 μm to about 62 μm, or about 28 μm to about 62 μm, or about 29 μm to about 62 μm, or about 30 μm to about 62 μm, or about 31 μm to about 62 μm, or about 32 μm to about 62 μm, or about 33 μm to about 62 μm, or about 34 μm to about 62 μm, or about 35 μm to about 62 μm, or about 36 μm to about 62 μm, or about 37 μm to about 62 μm, or about 38 μm to about 62 μm, or about 39 μm to about 62 μm, or about 40 μm to about 62 μm, or about 41 μm to about 62 μm, or about 42 μm to about 62 μm, or about 43 μm to about 62 μm, or about 44 μm to about 62 μm, or about 45 μm to about 62 μm, or about 46 μm to about 62 μm, or about 47 μm to about 62 μm, or about 48 μm to about 62 μm, or about 49 μm to about 62 μm, or about 50 μm to about 62 μm, or about 51 μm to about 62 μm, or about 52 μm to about 62 μm, or about 53 μm to about 62 μm, or about 54 μm to about 62 μm, or about 55 μm to about 62 μm, or about 56 μm m to about 62 μm, or about 57 μm to about 62 μm, or about 58 μm to about 62 μm, or about 59 μm to about 62 μm, or about 60 μm to about 62 μm, or about 61 μm to about 62 μm, or about 25 μm to about 61 μm, or about 26 μm to about 61 μm, or about 27 μm to about 61 μm, or about 28 μm to about 61 μm, or about 29 μm to about 61 μm, or about 30 μm to about 61 μm, or about 31 μm to about 61 μm, or about 32 μm to about 61 μm, or about 33 μm to about 61 μm, or about 34 μm to about 61 μm,or about 35 μm to about 61 μm, or about 36 μm to about 61 μm, or about 37 μm to about 61 μm, or about 38 μm to about 61 μm, or about 39 μm to about 61 μm, or about 40 μm to about 61 μm, or about 41 μm to about 61 μm, or about 42 μm to about 61 μm, or about 43 μm to about 61 μm, or about 44 μm to about 61 μm, or about 45 μm to about 61 μm, or about 46 μm to about 61 μm, or about 47 μm to about 61 μm, or about 48 μm to about 61 μm, or about 49 μm to about 61 μm, or about 50 μm m to about 61 μm, or about 51 μm to about 61 μm, or about 52 μm to about 61 μm, or about 53 μm to about 61 μm, or about 54 μm to about 61 μm, or about 55 μm to about 61 μm, or about 56 μm to about 61 μm, or about 57 μm to about 61 μm, or about 58 μm to about 61 μm, or about 59 μm to about 61 μm, or about 60 μm to about 61 μm, or about 25 μm to about 60 μm, or about 26 μm to about 60 μm, or about 27 μm to about 60 μm, or about 28 μm to about 60 μm, or about 29 μm to about 60 μm, or about 30 μm to about 60 μm, or about 31 μm to about 60 μm, or about 32 μm to about 60 μm, or about 33 μm to about 60 μm, or about 34 μm to about 60 μm, or about 35 μm to about 60 μm, or about 36 μm to about 60 μm, or about 37 μm to about 60 μm, or about 38 μm to about 60 μm, or about 39 μm to about 60 μm, or about 40 μm to about 60 μm, or about 41 μm to about 60 μm, or about 42 μm to about 60 μm, or about 43 μm to about 60 μm, or about 44 μm to about 60 μm, or about 45 μm m to about 60 μm, or about 46 μm to about 60 μm, or about 47 μm to about 60 μm, or about 48 μm to about 60 μm, or about 49 μm to about 60 μm, or about 50 μm to about 60 μm, or about 51 μm to about 60 μm, or about 52 μm to about 60 μm, or about 53 μm to about 60 μm, or about 54 μm to about 60 μm, or about 55 μm to about 60 μm, or about 56 μm to about 60 μm, or about 57 μm to about 60 μm, or about 58 μm to about 60 μm, or about 59 μm to about 60 μm, or about 25 μm to about 59 μm,or about 26 μm to about 59 μm, or about 27 μm to about 59 μm, or about 28 μm to about 59 μm, or about 29 μm to about 59 μm, or about 30 μm to about 59 μm, or about 31 μm to about 59 μm, or about 32 μm to about 59 μm, or about 33 μm to about 59 μm, or about 34 μm to about 59 μm, or about 35 μm to about 59 μm, or about 36 μm to about 59 μm, or about 37 μm to about 59 μm, or about 38 μm to about 59 μm, or about 39 μm to about 59 μm, or about 40 μm to about 59 μm, or about 41 μm μm to about 59 μm, or about 42 μm to about 59 μm, or about 43 μm to about 59 μm, or about 44 μm to about 59 μm, or about 45 μm to about 59 μm, or about 46 μm to about 59 μm, or about 47 μm to about 59 μm, or about 48 μm to about 59 μm, or about 49 μm to about 59 μm, or about 50 μm to about 59 μm, or about 51 μm to about 59 μm, or about 52 μm to about 59 μm, or about 53 μm to about 59 μm, or about 54 μm to about 59 μm, or about 55 μm to about 59 μm, or about 56 μm to about 59 μm, or about 57 μm to about 59 μm, or about 58 μm to about 59 μm, or about 25 μm to about 58 μm, or about 26 μm to about 58 μm, or about 27 μm to about 58 μm, or about 28 μm to about 58 μm, or about 29 μm to about 58 μm, or about 30 μm to about 58 μm, or about 31 μm to about 58 μm, or about 32 μm to about 58 μm, or about 33 μm to about 58 μm, or about 34 μm to about 58 μm, or about 35 μm to about 58 μm, or about 36 μm to about 58 μm, or about 37 μm to about 58 μm, or about 38 μm m to about 58 μm, or about 39 μm to about 58 μm, or about 40 μm to about 58 μm, or about 41 μm to about 58 μm, or about 42 μm to about 58 μm, or about 43 μm to about 58 μm, or about 44 μm to about 58 μm, or about 45 μm to about 58 μm, or about 46 μm to about 58 μm, or about 47 μm to about 58 μm, or about 48 μm to about 58 μm, or about 49 μm to about 58 μm, or about 50 μm to about 58 μm, or about 51 μm to about 58 μm, or about 52 μm to about 58 μm, or about 53 μm to about 58 μm,or about 54 μm to about 58 μm, or about 55 μm to about 58 μm, or about 56 μm to about 58 μm, or about 57 μm to about 58 μm, or about 25 μm to about 57 μm, or about 26 μm to about 57 μm, or about 27 μm to about 57 μm, or about 28 μm to about 57 μm, or about 29 μm to about 57 μm, or about 30 μm to about 57 μm, or about 31 μm to about 57 μm, or about 32 μm to about 57 μm, or about 33 μm to about 57 μm, or about 34 μm to about 57 μm, or about 35 μm to about 57 μm, or about 36 μm m to about 57 μm, or about 37 μm to about 57 μm, or about 38 μm to about 57 μm, or about 39 μm to about 57 μm, or about 40 μm to about 57 μm, or about 41 μm to about 57 μm, or about 42 μm to about 57 μm, or about 43 μm to about 57 μm, or about 44 μm to about 57 μm, or about 45 μm to about 57 μm, or about 46 μm to about 57 μm, or about 47 μm to about 57 μm, or about 48 μm to about 57 μm, or about 49 μm to about 57 μm, or about 50 μm to about 57 μm, or about 51 μm to about 57 μm, or about 52 μm to about 57 μm, or about 53 μm to about 57 μm, or about 54 μm to about 57 μm, or about 55 μm to about 57 μm, or about 56 μm to about 57 μm, or about 25 μm to about 56 μm, or about 26 μm to about 56 μm, or about 27 μm to about 56 μm, or about 28 μm to about 56 μm, or about 29 μm to about 56 μm, or about 30 μm to about 56 μm, or about 31 μm to about 56 μm, or about 32 μm to about 56 μm, or about 33 μm to about 56 μm, or about 34 μm to about 56 μm, or about 35 μm m to about 56 μm, or about 36 μm to about 56 μm, or about 37 μm to about 56 μm, or about 38 μm to about 56 μm, or about 39 μm to about 56 μm, or about 40 μm to about 56 μm, or about 41 μm to about 56 μm, or about 42 μm to about 56 μm, or about 43 μm to about 56 μm, or about 44 μm to about 56 μm, or about 45 μm to about 56 μm, or about 46 μm to about 56 μm, or about 47 μm to about 56 μm, or about 48 μm to about 56 μm, or about 49 μm to about 56 μm, or about 50 μm to about 56 μm,or about 51 μm to about 56 μm, or about 52 μm to about 56 μm, or about 53 μm to about 56 μm, or about 54 μm to about 56 μm, or about 55 μm to about 56 μm, or about 25 μm to about 55 μm, or about 26 μm to about 55 μm, or about 27 μm to about 55 μm, or about 28 μm to about 55 μm, or about 29 μm to about 55 μm, or about 30 μm to about 55 μm, or about 31 μm to about 55 μm, or about 32 μm to about 55 μm, or about 33 μm to about 55 μm, or about 34 μm to about 55 μm, or about 35 μm m to about 55 μm, or about 36 μm to about 55 μm, or about 37 μm to about 55 μm, or about 38 μm to about 55 μm, or about 39 μm to about 55 μm, or about 40 μm to about 55 μm, or about 41 μm to about 55 μm, or about 42 μm to about 55 μm, or about 43 μm to about 55 μm, or about 44 μm to about 55 μm, or about 45 μm to about 55 μm, or about 46 μm to about 55 μm, or about 47 μm to about 55 μm, or about 48 μm to about 55 μm, or about 49 μm to about 55 μm, or about 50 μm to about 55 μm, or about 51 μm to about 55 μm, or about 52 μm to about 55 μm, or about 53 μm to about 55 μm, or about 54 μm to about 55 μm, or about 25 μm to about 54 μm, or about 26 μm to about 54 μm, or about 27 μm to about 54 μm, or about 28 μm to about 54 μm, or about 29 μm to about 54 μm, or about 30 μm to about 54 μm, or about 31 μm to about 54 μm, or about 32 μm to about 54 μm, or about 33 μm to about 54 μm, or about 34 μm to about 54 μm, or about 35 μm to about 54 μm, or about 36 μm m to about 54 μm, or about 37 μm to about 54 μm, or about 38 μm to about 54 μm, or about 39 μm to about 54 μm, or about 40 μm to about 54 μm, or about 41 μm to about 54 μm, or about 42 μm to about 54 μm, or about 43 μm to about 54 μm, or about 44 μm to about 54 μm, or about 45 μm to about 54 μm, or about 46 μm to about 54 μm, or about 47 μm to about 54 μm, or about 48 μm to about 54 μm, or about 49 μm to about 54 μm, or about 50 μm to about 54 μm, or about 51 μm to about 54 μm,or about 52 μm to about 54 μm, or about 53 μm to about 54 μm, or about 25 μm to about 53 μm, or about 26 μm to about 53 μm, or about 27 μm to about 53 μm, or about 28 μm to about 53 μm, or about 29 μm to about 53 μm, or about 30 μm to about 53 μm, or about 31 μm to about 53 μm, or about 32 μm to about 53 μm,

[0084] or about 33 μm to about 53 μm, or about 34 μm to about 53 μm, or about 35 μm to about 53 μm, or about 36 μm to about 53 μm, or about 37 μm to about 53 μm, or about 38 μm to about 53 μm, or about 39 μm to about 53 μm, or about 40 μm to about 53 μm, or about 41 μm to about 53 μm, or about 42 μm to about 53 μm, or about 43 μm to about 53 μm, or about 44 μm to about 53 μm, or about 45 μm to about 53 μm, or about 46 μm to about 53 μm, or about 47 μm to about 53 μm, or about 48 μm m to about 53 μm, or about 49 μm to about 53 μm, or about 50 μm to about 53 μm, or about 51 μm to about 53 μm, or about 52 μm to about 53 μm, or about 25 μm to about 52 μm, or about 26 μm to about 52 μm, or about 27 μm to about 52 μm, or about 28 μm to about 52 μm, or about 29 μm to about 52 μm, or about 30 μm to about 52 μm, or about 31 μm to about 52 μm, or about 32 μm to about 52 μm, or about 33 μm to about 52 μm, or about 34 μm to about 52 μm, or about 35 μm to about 52 μm, or about 36 μm to about 52 μm, or about 37 μm to about 52 μm, or about 38 μm to about 52 μm, or about 39 μm to about 52 μm, or about 40 μm to about 52 μm, or about 41 μm to about 52 μm, or about 42 μm to about 52 μm, or about 43 μm to about 52 μm, or about 44 μm to about 52 μm, or about 45 μm to about 52 μm, or about 46 μm to about 52 μm, or about 47 μm to about 52 μm, or about 48 μm to about 52 μm, or about 49 μm to about 52 μm, or about 50 μm to about 52 μm, or about 51 μm m to about 52 μm, or about 25 μm to about 51 μm, or about 26 μm to about 51 μm, or about 27 μm to about 51 μm, or about 28 μm to about 51 μm, or about 29 μm to about 51 μm, or about 30 μm to about 51 μm, or about 31 μm to about 51 μm, or about 32 μm to about 51 μm, or about 33 μm to about 51 μm, or about 34 μm to about 51 μm, or about 35 μm to about 51 μm, or about 36 μm to about 51 μm, or about 37 μm to about 51 μm, or about 38 μm to about 51 μm, or about 39 μm to about 51 μm,or about 40 μm to about 51 μm, or about 41 μm to about 51 μm, or about 42 μm to about 51 μm, or about 43 μm to about 51 μm, or about 44 μm to about 51 μm, or about 45 μm to about 51 μm, or about 46 μm to about 51 μm, or about 47 μm to about 51 μm, or about 48 μm to about 51 μm, or about 49 μm to about 51 μm, or about 50 μm to about 51 μm, or about 25 μm to about 50 μm, or about 26 μm to about 50 μm, or about 27 μm to about 50 μm, or about 28 μm to about 50 μm, or about 29 μm m to about 50 μm, or about 30 μm to about 50 μm, or about 31 μm to about 50 μm, or about 32 μm to about 50 μm, or about 33 μm to about 50 μm, or about 34 μm to about 50 μm, or about 35 μm to about 50 μm, or about 36 μm to about 50 μm, or about 37 μm to about 50 μm, or about 38 μm to about 50 μm, or about 39 μm to about 50 μm, or about 40 μm to about 50 μm, or about 41 μm to about 50 μm, or about 42 μm to about 50 μm, or about 43 μm to about 50 μm, or about 44 μm to about 50 μm, or about 45 μm to about 50 μm, or about 46 μm to about 50 μm, or about 47 μm to about 50 μm, or about 48 μm to about 50 μm, or about 49 μm to about 50 μm, or about 25 μm to about 49 μm, or about 26 μm to about 49 μm, or about 27 μm to about 49 μm, or about 28 μm to about 49 μm, or about 29 μm to about 49 μm, or about 30 μm to about 49 μm, or about 31 μm to about 49 μm, or about 32 μm to about 49 μm, or about 33 μm to about 49 μm, or about 34 μm to about 49 μm, or about 35 μm m to about 49 μm, or about 36 μm to about 49 μm, or about 37 μm to about 49 μm, or about 38 μm to about 49 μm, or about 39 μm to about 49 μm, or about 40 μm to about 49 μm, or about 41 μm to about 49 μm, or about 42 μm to about 49 μm, or about 43 μm to about 49 μm, or about 44 μm to about 49 μm, or about 45 μm to about 49 μm, or about 46 μm to about 49 μm, or about 47 μm to about 49 μm, or about 48 μm to about 49 μm, or about 25 μm to about 48 μm, or about 26 μm to about 48 μm,or about 27 μm to about 48 μm, or about 28 μm to about 48 μm, or about 29 μm to about 48 μm, or about 30 μm to about 48 μm, or about 31 μm to about 48 μm, or about 32 μm to about 48 μm, or about 33 μm to about 48 μm, or about 34 μm to about 48 μm, or about 35 μm to about 48 μm, or about 36 μm to about 48 μm, or about 37 μm to about 48 μm, or about 38 μm to about 48 μm, or about 39 μm to about 48 μm, or about 40 μm to about 48 μm, or about 41 μm to about 48 μm, or about 42 μm m to about 48 μm, or about 43 μm to about 48 μm, or about 44 μm to about 48 μm, or about 45 μm to about 48 μm, or about 46 μm to about 48 μm, or about 47 μm to about 48 μm, or about 25 μm to about 47 μm, or about 26 μm to about 47 μm, or about 27 μm to about 47 μm, or about 28 μm to about 47 μm, or about 29 μm to about 47 μm, or about 30 μm to about 47 μm, or about 31 μm to about 47 μm, or about 32 μm to about 47 μm, or about 33 μm to about 47 μm, or about 34 μm to about 47 μm, or about 35 μm to about 47 μm, or about 36 μm to about 47 μm, or about 37 μm to about 47 μm, or about 38 μm to about 47 μm, or about 39 μm to about 47 μm, or about 40 μm to about 47 μm, or about 41 μm to about 47 μm, or about 42 μm to about 47 μm, or about 43 μm to about 47 μm, or about 44 μm to about 47 μm, or about 45 μm to about 47 μm, or about 46 μm to about 47 μm, or about 25 μm to about 46 μm, or about 26 μm to about 46 μm, or about 27 μm to about 46 μm, or about 28 μm m to about 46 μm, or about 29 μm to about 46 μm, or about 30 μm to about 46 μm, or about 31 μm to about 46 μm, or about 32 μm to about 46 μm, or about 33 μm to about 46 μm, or about 34 μm to about 46 μm, or about 35 μm to about 46 μm, or about 36 μm to about 46 μm, or about 37 μm to about 46 μm, or about 38 μm to about 46 μm, or about 39 μm to about 46 μm, or about 40 μm to about 46 μm, or about 41 μm to about 46 μm, or about 42 μm to about 46 μm, or about 43 μm to about 46 μm,or about 44 μm to about 46 μm, or about 45 μm to about 46 μm, or about 25 μm to about 45 μm, or about 26 μm to about 45 μm, or about 27 μm to about 45 μm, or about 28 μm to about 45 μm, or about 29 μm to about 45 μm, or about 30 μm to about 45 μm, or about 31 μm to about 45 μm, or about 32 μm to about 45 μm, or about 33 μm to about 45 μm, or about 34 μm to about 45 μm, or about 35 μm to about 45 μm, or about 36 μm to about 45 μm, or about 37 μm to about 45 μm, or about 38 μm m to about 45 μm, or about 39 μm to about 45 μm, or about 40 μm to about 45 μm, or about 41 μm to about 45 μm, or about 42 μm to about 45 μm, or about 43 μm to about 45 μm, or about 44 μm to about 45 μm, or about 25 μm to about 44 μm, or about 26 μm to about 44 μm, or about 27 μm to about 44 μm, or about 28 μm to about 44 μm, or about 29 μm to about 44 μm, or about 30 μm to about 44 μm, or about 31 μm to about 44 μm, or about 32 μm to about 44 μm, or about 33 μm to about 44 μm, or about 34 μm to about 44 μm, or about 35 μm to about 44 μm, or about 36 μm to about 44 μm, or about 37 μm to about 44 μm, or about 38 μm to about 44 μm, or about 39 μm to about 44 μm, or about 40 μm to about 44 μm, or about 41 μm to about 44 μm, or about 42 μm to about 44 μm, or about 43 μm to about 44 μm, or about 25 μm to about 43 μm, or about 26 μm to about 43 μm, or about 27 μm to about 43 μm, or about 28 μm to about 43 μm, or about 29 μm to about 43 μm, or about 30 μm m to about 43 μm, or about 31 μm to about 43 μm, or about 32 μm to about 43 μm, or about 33 μm to about 43 μm, or about 34 μm to about 43 μm, or about 35 μm to about 43 μm, or about 36 μm to about 43 μm, or about 37 μm to about 43 μm, or about 38 μm to about 43 μm, or about 39 μm to about 43 μm, or about 40 μm to about 43 μm, or about 41 μm to about 43 μm, or about 42 μm to about 43 μm, or about 25 μm to about 42 μm, or about 26 μm to about 42 μm, or about 27 μm to about 42 μm,or about 28 μm to about 42 μm, or about 29 μm to about 42 μm, or about 30 μm to about 42 μm, or about 31 μm to about 42 μm, or about 32 μm to about 42 μm, or about 33 μm to about 42 μm, or about 34 μm to about 42 μm, or about 35 μm to about 42 μm, or about 36 μm to about 42 μm, or about 37 μm to about 42 μm, or about 38 μm to about 42 μm, or about 39 μm to about 42 μm, or about 40 μm to about 42 μm, or about 41 μm to about 42 μm, or about 25 μm to about 41 μm, or about 26 μm m to about 41 μm, or about 27 μm to about 41 μm, or about 28 μm to about 41 μm, or about 29 μm to about 41 μm, or about 30 μm to about 41 μm, or about 31 μm to about 41 μm, or about 32 μm to about 41 μm, or about 33 μm to about 41 μm, or about 34 μm to about 41 μm, or about 35 μm to about 41 μm, or about 36 μm to about 41 μm, or about 37 μm to about 41 μm, or about 38 μm to about 41 μm, or about 39 μm to about 41 μm, or about 40 μm to about 41 μm, or about 25 μm to about 40 μm, or about 26 μm to about 40 μm, or about 27 μm to about 40 μm, or about 28 μm to about 40 μm, or about 29 μm to about 40 μm, or about 30 μm to about 40 μm, or about 31 μm to about 40 μm, or about 32 μm to about 40 μm, or about 33 μm to about 40 μm, or about 34 μm to about 40 μm, or about 35 μm to about 40 μm, or about 36 μm to about 40 μm, or about 37 μm to about 40 μm, or about 38 μm to about 40 μm, or about 39 μm to about 40 μm, or about 25 μm to about 39 μm, or about 26 μm μm to about 39 μm, or about 27 μm to about 39 μm, or about 28 μm to about 39 μm, or about 29 μm to about 39 μm, or about 30 μm to about 39 μm, or about 31 μm to about 39 μm, or about 32 μm to about 39 μm, or about 33 μm to about 39 μm, or about 34 μm to about 39 μm, or about 35 μm to about 39 μm, or about 36 μm to about 39 μm, or about 37 μm to about 39 μm, or about 38 μm to about 39 μm, or about 25 μm to about 38 μm, or about 26 μm to about 38 μm, or about 27 μm to about 38 μm,or about 28 μm to about 38 μm, or about 29 μm to about 38 μm, or about 30 μm to about 38 μm, or about 31 μm to about 38 μm, or about 32 μm to about 38 μm, or about 33 μm to about 38 μm, or about 34 μm to about 38 μm, or about 35 μm to about 38 μm, or about 36 μm to about 38 μm, or about 37 μm to about 38 μm,

[0085] or about 25 μm to about 37 μm, or about 26 μm to about 37 μm, or about 27 μm to about 37 μm, or about 28 μm to about 37 μm, or about 29 μm to about 37 μm, or about 30 μm to about 37 μm, or about 31 μm to about 37 μm, or about 32 μm to about 37 μm, or about 33 μm to about 37 μm, or about 34 μm to about 37 μm, or about 35 μm to about 37 μm, or about 36 μm to about 37 μm, or about 25 μm to about 36 μm, or about 26 μm to about 36 μm, or about 27 μm to about 36 μm, or about 28 μm m to about 36 μm, or about 29 μm to about 36 μm, or about 30 μm to about 36 μm, or about 31 μm to about 36 μm, or about 32 μm to about 36 μm, or about 33 μm to about 36 μm, or about 34 μm to about 36 μm, or about 35 μm to about 36 μm, or about 25 μm to about 35 μm, or about 26 μm to about 35 μm, or about 27 μm to about 35 μm, or about 28 μm to about 35 μm, or about 29 μm to about 35 μm, or about 30 μm to about 35 μm, or about 31 μm to about 35 μm, or about 32 μm to about 35 μm, or about 33 μm to about 35 μm, or about 34 μm to about 35 μm, or about 25 μm to about 34 μm, or about 26 μm to about 34 μm, or about 27 μm to about 34 μm, or about 28 μm to about 34 μm, or about 29 μm to about 34 μm, or about 30 μm to about 34 μm, or about 31 μm to about 34 μm, or about 32 μm to about 34 μm, or about 33 μm to about 34 μm, or about 25 μm to about 33 μm, or about 26 μm to about 33 μm, or about 27 μm to about 33 μm, or about 28 μm to about 33 μm, or about 29 μm m to about 33 μm, or about 30 μm to about 33 μm, or about 31 μm to about 33 μm, or about 32 μm to about 33 μm, or about 25 μm to about 32 μm, or about 26 μm to about 32 μm, or about 27 μm to about 32 μm, or about 28 μm to about 32 μm, or about 29 μm to about 32 μm, or about 30 μm to about 32 μm, or about 31 μm to about 32 μm, or about 25 μm to about 31 μm, or about 26 μm to about 31 μm, or about 27 μm to about 31 μm, or about 28 μm to about 31 μm, or about 29 μm to about 31 μm,or about 30 μm to about 31 μm, or about 25 μm to about 30 μm, or about 26 μm to about 30 μm, or about 27 μm to about 30 μm, or about 28 μm to about 30 μm, or about 29 μm to about 30 μm, or about 25 μm to about 29 μm, or about 26 μm to about 29 μm, or about 27 μm to about 29 μm, or about 28 μm to about 29 μm, or about 25 μm to about 28 μm, or about 26 μm to about 28 μm, or about 27 μm to about 28 μm, or about 25 μm to about 27 μm, or about 26 μm to about 27 μm, or about 25 μm to about 26 μm, or 25 μm, The treated aragonite calcium carbonate particles may be composed of particles having a particle size of 6 μm, 27 μm, 28 μm, 29 μm, 30 μm, 31 μm, 32 μm, 33 μm, 34 μm, 35 μm, 36 μm, 37 μm, 38 μm, 39 μm, 40 μm, 41 μm, 42 μm, 43 μm, 44 μm, 45 μm, 46 μm, 47 μm, 48 μm, 49 μm, 50 μm, 51 μm, 52 μm, 53 μm, 54 μm, 55 μm, 56 μm, 57 μm, 58 μm, 59 μm, 60 μm, 61 μm, 62 μm, 63 μm, 64 μm, 65 μm, 66 μm, 67 μm, 68 μm, 69 μm, or 70 μm.

[0086] According to the DESAUTELS and LABRECHE 1999 scale, the preferred abrasiveness ratio value is between 0 and 88. The DESAUTELS and LABRECHE abrasiveness scale varies in toothpastes as follows: 1) slightly abrasive: 0%-88%; 2) abrasive to moderately abrasive: 88%-100% and 3) very abrasive: >100%.

[0087] Specific surface area (SSA), or Brunauer, Emmett and Teller (BET) SSA, is a property of solids defined as the total surface area of ​​a material per unit of mass. The particles of treated aragonite calcium carbonate of the present invention have a viscosity of about 2.7 to about 3.1, or about 2.75 to about 3.1, or about 2.8 to about 3.1, or about 2.85 to about 3.1, or about 2.9 to about 3.1, or about 2.95 to about 3.1, or about 3 to about 3.1, or about 3.05 to about 3.1, or about 2.7 to about 3.05, or about 2.75 to about 3.05, or about 2.8 to about 3.05, or about 2.85 to about 3.05, or about 2.9 to about 3.05, or about 2.95 to about 3.05, or about 3 to about 3.05, or about 2.7 to about 3.00, or about 2.75 to about 3.00, or about 2.8 to about 3.00, or about 2.85 to about 3.00, or about 2.9 to about 3.00, or about 2.95 to about 3.00, or about 2.7 to about 2.95, or about 2.75 to about 2.95, or about 2.8 to about 2.95, or about 2.85 to about 2.95, or about 2.9 to about 2.95, or about 2.7 to about 2.90, or about 2.75 to about 2.90, or about 2.8 to about 2.90, or about 2.85 to about 2.90, or about 2.7 to about 2.85, or about 2.75 to about 2.85, or about 2.8 to about 2.85, or about 2.7 to about 2.80, or about 2.75 to about 2.80, or about 2.7 to about 2.75, or 2.7, 2.75, 2.8, 2.85, 2.9, 2.95, 3, 3.05, or 3.1 m 2 / g specific surface area (m 2 / g).

[0088] Crystallinity refers to the degree of structural regularity in a solid. In a crystal, atoms or molecules are regularly and periodically arranged. The degree of crystallinity affects the hardness, density, transparency, and diffusivity of the solid. The crystallinity of the treated roe-like aragonite used in the present invention is about 24% to about 28%, or about 24% to about 27.5%, or about 24% to about 27%, or about 24% to about 26.5%, or about 24% to about 26%, or about 24% to about 25.5%, or about 24% to about 25%, or about 24% to about 24.5%, or about 24.5%. about 28%, or about 24.5% to about 27.5%, or about 24.5% to about 27%, or about 24.5% to about 26.5%, or about 24.5% to about 26%, or about 24.5% to about 25.5%, or about 24.5% to about 25%, or about 25% to about 28%, or about 25% to about 27.5%, or about 25% to about 27%, or about 25% to about 2 6.5%, or about 25% to about 26%, or about 25% to about 25.5%, or about 25.5% to about 28%, or about 25.5% to about 27.5%, or about 25.5% to about 27%, or about 25.5% to about 26.5%, or about 25.5% to about 26%, or about 26% to about 28%, or about 26% to about 27.5%, or about 26% to about 27% , or about 26% to about 26.5%, or about 26.5% to about 28%, or about 26.5% to about 27.5%, or about 26.5% to about 27%, or about 27% to about 28%, or about 27% to about 27.5%, or about 27.5% to about 28%, or about 24, 24.5, 25, 25.5, 26, 26.5, 27, 27.5, or 28%.

[0089] The particles of treated aragonite calcium carbonate of the present invention have a pH of about 4.5 to about 5.5, or about 4.5 to about 5.4, or about 4.5 to about 5.3, or about 4.5 to about 5.2, or about 4.5 to about 5.1, or about 4.5 to about 5.0, or about 4.5 to about 4.9, or about 4.5 to about 4.8, or about 4.5 to about 4.7, or about 4.5 to about 4.6, or about 4.6 to about 5.5, or about 4.6 to about 5.5, in order to solubilize undesirable magnesium, ammonia, iron and zinc compounds present in the bone material and increase the calcium carbonate content of the powder of the present invention. is about 4.6 to about 5.4, or about 4.6 to about 5.3, or about 4.6 to about 5.2, or about 4.6 to about 5.1, or about 4.6 to about 5.0, or about 4.6 to about 4.9, or about 4.6 to about 4.8, or about 4.6 to about 4.7, or about 4.7 to about 5.5, or about 4.7 to about 5.4, or about 4.7 to about 5.3, or about 4.7 to about 5.2, or about 4.7 to about 5.1, or about 4.7 to about 5.0, or about 4.7 to about 4.9, or about 4.7 to about 4.8, or about 4.8 to about 5.5, or about 4.8 to about 5.4, or about 4.8 to about 5.3, or about 4.8 to about 5.2, or about 4.8 to about 5.1, or about 4.8 to about 5.0, or about 4.8 to about 4.9, or about 4.9 to about 5.5, or about 4.9 to about 5.4, or about 4.9 to about 5.3, or about 4.9 to about 5.2, or about 4.9 to about 5.1, or about 4.9 to about 5.0, or about 5.0 to about 5.5, or about 5.0 to about 5.4, or about 5.0 to about 5.3, or about 5.0 to about 5.2, or about 5.0 to about 5.1, or about 5.1 to about 5.5, or about 5.1 to about 5.4, or about 5.1 to about 5. or about 5.3, or about 5.1 to about 5.2, or about 5.2 to about 5.5, or about 5.2 to about 5.4, or about 5.2 to about 5.3, or about 5.3 to about 5.5, or about 5.3 to about 5.4, or about 5.4 to about 5.5, preferably about pH 4.75, 4.76, 4.77, 4.78, 4.79, 4.80, 4.81, 4.82, 4.83, 4.84, 4.85, 4.86, 4.87, 4.88, 4.89, 4.90, most preferably 4.86, for example, in ammonium chloride or ammonium acetate.Indeed, the bone powder used in the present invention contains a high content of calcium; it contains at least 95% calcium carbonate, with reduced amounts of magnesium, zinc, iron and ammonia-containing derivatives. According to an embodiment, the calcium carbonate of the cuttlebone powder particles is at least 95%, at least 95.5%, at least 96%, at least 96.5%, at least 97%, at least 97.5%, at least 98%, at least 98.5%, at least 99%, or about 95% to 99% (w / w), or about 95% to 98.5% (w / w), or about 95% to about 98%, or about 95% to 97.5% (w / w), or is about 95% to about 97%, or about 95% to 96.5% (w / w), or about 95% to about 96%, or about 95% to 95.5% (w / w), or about 95.5% to 99% (w / w), or about 95.5% to 98.5% (w / w), or about 95.5% to about 98%, or about 95.5% to 97.5% (w / w), or about 95.5% to about 97%, or about 95.5% to 96.5% (w / w), or about 95.5% to about 96% , or about 96% to 99% (w / w), or about 96% to 98.5% (w / w), or about 96% to about 98%, or about 96% to 97.5% (w / w), or about 96% to about 97%, or about 96% to 96.5% (w / w), or about 96.5% to 99% (w / w), or about 96.5% to 98.5% (w / w), or about 96.5% to about 98%, or about 96.5% to 97.5% (w / w), or about 96.5% to about It may be 97%, or about 97%-99% (w / w), or about 97%-98.5% (w / w), or about 97% to about 98%, or about 97%-97.5% (w / w), or about 97.5%-99% (w / w), or about 97.5%-98.5% (w / w), or about 97.5% to about 98%, or about 98%-99% (w / w), or about 98%-98.5% (w / w), or about 98.5%-99% (w / w).

[0090] In embodiments, the weak acid treatment can be carried out using weak acids such as ammonium chloride, ammonium bromide, ammonium acetate, ammonium carbonate, ammonium phosphate, ammonium formate, ammonium malate, triammonium citrate, ammonium tartrate, acetic acid, citric acid, ascorbic acid, tannic acid, boric acid, lactic acid, formic acid, oxalic acid, uric acid, malic acid, tartaric acid, phosphorous acid, and the like. Stronger acids such as hydrochloric acid and phosphoric acid may be used under dilute conditions that result in a weak acid treatment of the calcium carbonate.

[0091] In an embodiment, the concentration of the acid to effect the weak acid treatment will vary depending on the acid compound used. For example, for ammonium chloride, the concentration may be about 0.1M to about 10M, preferably about 1.87M or 2M.

[0092] According to an embodiment of the present invention, the above-mentioned treated roe-like aragonite calcium carbonate is present in an amount of about 0.1% to about 25% (w / w) of the composition, or about 0.1% to about 25% (w / w), or about 0.1% to about 25% (w / w), or about 0.1% to about 24%, or about 0.1% to about 23%, or about 0.1% to about 22%, or about 0.1% to about 21%, or about 0.1% to about 20%, or about 0.1% to about 19%, or about 0.1% to about 18%, or about 0.1% to about 17%, or about 0.1% to about 16%, or about 0.1% to about 15%. %, or about 0.1% to about 14%, or about 0.1% to about 13%, or about 0.1% to about 12%, or about 0.1% to about 11%, or about 0.1% to about 10%, or about 0.1% to about 9%, or about 0.1% to about 8%, or about 0.1% to about 7%, or about 0.1% to about 6%, or about 0.1% to about 5%, or about 0.1% to about 4%, or about 0.1% to about 3%, or about 0.1% to about 2%, or about 0.1% to about 1%, or about 0.1% to about 0.5%, or about 0.5% to about 25% (w / w), or about 0.5% to about 25% (w / w), or about 0.5% to about 25% (w / w), or about 0.5% to about 24%, or about 0.5% to about 23%, or about 0.5% to about 22%, or about 0.5% to about 21%, or about 0.5% to about 20%, or about 0.5% to about 19%, or about 0.5% to about 18%, or about 0.5% to about 17%, or about 0.5% to about 16%, or about 0.5% to about 15%, or about 0.5% to about 14%, or about 0.5% to about 13%, or about 0.50.5% to about 12%, or about 0.5% to about 11%, or about 0.5% to about 10%, or about 0.5% to about 9%, or about 0.5% to about 8%, or about 0.5% to about 7%, or about 0.5% to about 6%, or about 0.5% to about 5%, or about 0.5% to about 4%, or about 0.5% to about 3%, or about 0.5% to about 2%, or about 0.5% to about 1%, or about 1% to about 25% (w / w), or about 1% to about 25% (w / w), or about 1% to about 24%, or about 1% to about 23%, or about 1% to about 22%, or about 1% to about 21%, or about 1% to about 20%, or about 1% to about 19%,or about 1% to about 18%, or about 1% to about 17%, or about 1% to about 16%, or about 1% to about 15%, or about 1% to about 14%, or about 1% to about 13%, or about 1% to about 12%, or about 1% to about 11%, or about 1% to about 10%, or about 1% to about 9%, or about 1% to about 8%, or about 1% to about 7%, or about 1% to about 6%, or about 1% to about 5%, or about 1% to about 4%, or about 1% to about 3%, or about 1% to about 2%, or about 2% to about 25% (w / w), or about 2% to about 24%, or from about 2% to about 23%, or from about 2% to about 22%, or from about 2% to about 21%, or from about 2% to about 20%, or from about 2% to about 19%, or from about 2% to about 18%, or from about 2% to about 17%, or from about 2% to about 16%, or from about 2% to about 15%, or from about 2% to about 14%, or from about 2% to about 13%, or from about 2% to about 12%, or from about 2% to about 11%, or from about 2% to about 10%, or from about 2% to about 9%, or from about 2% to about 8%, or from about 2% to about 7%, or from about 2% to about 6%, or from about 2% to about 5%, or from about 2% to about 4% , or about 2% to about 3%, or about 3% to about 25% (w / w), or about 3% to about 24%, or about 3% to about 23%, or about 3% to about 22%, or about 3% to about 21%, or about 3% to about 20%, or about 3% to about 19%, or about 3% to about 18%, or about 3% to about 17%, or about 3% to about 16%, or about 3% to about 15%, or about 3% to about 14%, or about 3% to about 13%, or about 3% to about 12%, or about 3% to about 11%, or about 3% to about 10%, or about 3% to about 9%, or about 3% to about 8% , or about 3% to about 7%, or about 3% to about 6%, or about 3% to about 5%, or about 3% to about 4%, or about 4% to about 25% (w / w), or about 4% to about 24%, or about 4% to about 23%, or about 4% to about 22%, or about 4% to about 21%, or about 4% to about 20%, or about 4% to about 19%, or about 4% to about 18%, or about 4% to about 17%, or about 4% to about 16%, or about 4% to about 15%, or about 4% to about 14%, or about 4% to about 13%, or about 4% to about 12%, or about 4% to about 11%,or about 4% to about 10%, or about 4% to about 9%, or about 4% to about 8%, or about 4% to about 7%, or about 4% to about 6%, or about 4% to about 5%, or about 5% to about 25% (w / w), or about 5% to about 24%, or about 5% to about 23%, or about 5% to about 22%, or about 5% to about 21%, or about 5% to about 20%, or about 5% to about 19%, or about 5% to about 18%, or about 5% to about 17%, or about 5% to about 16%, or about 5% to about 15%, or about 5% to about 14%, or about 5% to about 13%, or or about 5% to about 12%, or about 5% to about 11%, or about 5% to about 10%, or about 5% to about 9%, or about 5% to about 8%, or about 5% to about 7%, or about 5% to about 6%, or about 6% to about 25% (w / w), or about 6% to about 24%, or about 6% to about 23%, or about 6% to about 22%, or about 6% to about 21%, or about 6% to about 20%, or about 6% to about 19%, or about 6% to about 18%, or about 6% to about 17%, or about 6% to about 16%, or about 6% to about 15%, or about 6% to about 14%, or or about 6% to about 13%, or about 6% to about 12%, or about 6% to about 11%, or about 6% to about 10%, or about 6% to about 9%, or about 6% to about 8%, or about 6% to about 7%, or about 7% to about 25% (w / w), or about 7% to about 24%, or about 7% to about 23%, or about 7% to about 22%, or about 7% to about 21%, or about 7% to about 20%, or about 7% to about 19%, or about 7% to about 18%, or about 7% to about 17%, or about 7% to about 16%, or about 7% to about 15%, or about 7% to about 14%, or or about 7% to about 13%, or about 7% to about 12%, or about 7% to about 11%, or about 7% to about 10%, or about 7% to about 9%, or about 7% to about 8%, or about 8% to about 25% (w / w), or about 8% to about 24%, or about 8% to about 23%, or about 8% to about 22%, or about 8% to about 21%, or about 8% to about 20%, or about 8% to about 19%, or about 8% to about 18%, or about 8% to about 17%, or about 8% to about 16%, or about 8% to about 15%, or about 8% to about 14%, or about 8% to about 13%,or about 8% to about 12%, or about 8% to about 11%, or about 8% to about 10%, or about 8% to about 9%, or about 9% to about 25% (w / w), or about 9% to about 24%, or about 9% to about 23%, or about 9% to about 22%, or about 9% to about 21%, or about 9% to about 20%, or about 9% to about 19%, or about 9% to about 18%, or about 9% to about 17%, or about 9% to about 16%, or about 9% to about 15%, or about 9% to about 14%, or about 9% to about 13%, or about 9% to about 12%, or about 9% to about 11% %, or about 9% to about 10%, or about 10% to about 25% (w / w), or about 10% to about 24%, or about 10% to about 23%, or about 10% to about 22%, or about 10% to about 21%, or about 10% to about 20%, or about 10% to about 19%, or about 10% to about 18%, or about 10% to about 17%, or about 10% to about 16%, or about 10% to about 15%, or about 10% to about 14%, or about 10% to about 13%, or about 10% to about 12%, or about 10% to about 11%, or about 11% to about 25% (w / w), or about 11% to about 24%, or about 11% to about 23%, or about 11% to about 22%, or about 11% to about 21%, or about 11% to about 20%, or about 11% to about 19%, or about 11% to about 18%, or about 11% to about 17%, or about 11% to about 16%, or about 11% to about 15%, or about 11% to about 14%, or about 11% to about 13%, or about 11% to about 12%, or about 12% to about 25% (w / w), or about 12% to about 24%, or about 12% to about 23%, or about 12% to about 22%, or about 12% to about 25% (w / w), ... % to about 21%, or about 12% to about 20%, or about 12% to about 19%, or about 12% to about 18%, or about 12% to about 17%, or about 12% to about 16%, or about 12% to about 15%, or about 12% to about 14%, or about 12% to about 13%, or about 13% to about 25% (w / w), or about 13% to about 24%, or about 13% to about 23%, or about 13% to about 22%, or about 13% to about 21%, or about 13% to about 20%, or about 13% to about 19%, or about 13% to about 18%, or about 13% to about 17%,or about 13% to about 16%, or about 13% to about 15%, or about 13% to about 14%, or about 14% to about 25% (w / w), or about 14% to about 24%, or about 14% to about 23%, or about 14% to about 22%, or about 14% to about 21%, or about 14% to about 20%, or about 14% to about 19%, or about 14% to about 18%, or about 14% to about 17%, or about 14% to about 16%, or about 14% to about 15%, or about 15% to about 25% (w / w), or about 15% to about 24%, or about 15% to about 23% , or about 15% to about 22%, or about 15% to about 21%, or about 15% to about 20%, or about 15% to about 19%, or about 15% to about 18%, or about 15% to about 17%, or about 15% to about 16%, or about 16% to about 25% (w / w), or about 16% to about 24%, or about 16% to about 23%, or about 16% to about 22%, or about 16% to about 21%, or about 16% to about 20%, or about 16% to about 19%, or about 16% to about 18%, or about 16% to about 17%, or about 17% to about 25% (w / w ), or about 17% to about 24%, or about 17% to about 23%, or about 17% to about 22%, or about 17% to about 21%, or about 17% to about 20%, or about 17% to about 19%, or about 17% to about 18%, or about 18% to about 25% (w / w), or about 18% to about 24%, or about 18% to about 23%, or about 18% to about 22%, or about 18% to about 21%, or about 18% to about 20%, or about 18% to about 19%, or about 19% to about 25% (w / w), or about 19% to about 24%, or about 19% to about 2 3%, or about 19% to about 22%, or about 19% to about 21%, or about 19% to about 20%, or about 20% to about 25% (w / w), or about 20% to about 24%, or about 20% to about 23%, or about 20% to about 22%, or about 20% to about 21%, or about 21% to about 25% (w / w), or about 21% to about 24%, or about 21% to about 23%, or about 21% to about 22%, or about 22% to about 25% (w / w), or about 22% to about 24%, or about 22% to about 23%, or about 23% to about 25% (w / w),Or about 23% to about 24%, or about 24% to about 25% (w / w), or 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25%.

[0093] Preferred embodiments may include amounts from about 4.3%, 5%, 6.3%, 8.5%, 10%, 11.2%, 11.5, 12%, 15%, and 15.2% w / w.

[0094] In an embodiment, the compositions of the present invention include a fluoride compound suitable for providing beneficial fluoride treatment to teeth. In an embodiment, the fluoride compound may be sodium fluoride (NaF), stannous fluoride (SnF2), sodium monofluorophosphate (MFP - Na2PO3F), or a combination thereof. The fluoride compound may be present in a concentration of about 800 ppm to about 5000 ppm fluoride, or about 1000 ppm to about 1500 ppm fluoride, or 800, 1000, 1500, or 5000 ppm fluoride.

[0095] The compositions of the present invention may comprise several components, including: Abrasives According to one embodiment, the oral care composition of the present invention may contain a second dental abrasive in addition to the treated aragonite calcium carbonate (CaCO3) particles used in the present invention. Preferably, the abrasive is selected from colloidal calcium or colloidal silica. Suitable abrasives include hydrous silica and sodium bicarbonate (NaHCO3). Other suitable abrasives include, but are not limited to, aluminum hydroxide (Al(OH)3), calcium carbonate (CaCO3), various calcium hydrogen phosphates (CaHPO4·2H2O, or anhydrous), various silicas (fumed silica, precipitated silica, etc.) and zeolites, and hydroxyapatite (Ca5(PO4)3OH). Abrasives are insoluble particles that help to remove tartar (plaque) from teeth and dead cells from skin. In toothpaste systems, the abrasive silica has been shown to be the main dental cleaning and polishing agent. In an embodiment, the second dental abrasive may be sodium bicarbonate (NaHCO3), colloidal silica, or a combination thereof.

[0096] According to one embodiment, the second dental abrasive comprises from about 0.100% to about 30%, or from about 1% to about 30%, or from about 2% to about 30%, or from about 3% to about 30%, or from about 4% to about 30%, or from about 5% to about 30%, or from about 6% to about 30%, or from about 7% to about 30%, or from about 8% to about 30%, or from about 9% to about 30%, or from about 10% to about 30%, or from about 11% to about 30%, or from about 12% to about 30%, or from about 13% to about 30%, or from about 14% to about 30%, or from about 15% to about 30%, or from about 16% to about 30%, or from about 17% to about 30%, or from about 18% to about 30%, or from about 19% to about 30%, or from about 20% to about 30%, or from about 21% to about 30%, or from about 22% to about 30%, or from about 23% to about 30%, or from about 24% to about 30%, or from about 25% to about 30%, or from about 26% to about 30%, or from about 27% to about 30%, or from about 28% to about 30%, or from about 29% to about 40%, or from about 30% to about 40%, or from about 31% to about 30%, or from about 32% to about 30%, or from about 33% to about 30%, or from about 34% to about 30%, or from about 35% to about 30%, or from about 36% to about 30%, or from about 37% to about 30%, or from about 38% to about 30 % to about 30%, or about 14% to about 30%, or about 15% to about 30%, or about 16% to about 30%, or about 17% to about 30%, or about 18% to about 30%, or about 19% to about 30%, or about 20% to about 30%, or about 21% to about 30%, or about 22% to about 30%, or about 23% to about 30%, or about 24% to about 30%, or about 25% to about 30%, or about 26% to about 30%, or about 27% to about 30%, or or about 28% to about 30%, or about 29% to about 30%, or 0.100% to about 20%, or about 1% to about 20%, or about 2% to about 20%, or about 3% to about 20%, or about 4% to about 20%, or about 5% to about 20%, or about 6% to about 20%, or about 7% to about 20%, or about 8% to about 20%, or about 9% to about 20%, or about 10% to about 20%, or about 11% to about 20%, or about 12% to about 20%, or In another embodiment, the colloidal silica may comprise about 0.1% to about 20% (w / w) of the composition. In another embodiment, the sodium bicarbonate (NaHCO3) may comprise about 0.02% to about 0.75% (w / w) of the composition.

[0097] Thickener According to one embodiment, the personal care compositions of the present invention may contain a thickening agent.

[0098] A thickener, or thickener, is a substance that increases the viscosity of a solution or liquid / solid mixture without substantially altering other properties; it is most frequently applied to foods where the desired property is taste, but the term is also applicable to paints, inks, explosives, etc. Thickeners are sometimes referred to as "natural gums". Thickeners can also improve the suspension of other ingredients or emulsions, increasing the stability of the product. Thickeners are often regulated as food additives and as cosmetic and personal hygiene product ingredients. Some thickeners are gelling agents (gelants), which dissolve in the liquid phase as colloidal mixtures that form gels and have a weak internal structure. Examples of suitable thickening agents include, but are not limited to, natural gums obtained from seaweeds such as agar (E406), alginic acid (E400) and sodium alginate (E401), potassium alginate, ammonium alginate, calcium alginate, carrageenan (E407); natural gums obtained from non-marine plant sources, acacia gum, gum arabic (E414), gum ghatti, gum tragacanth (E413), gum karaya (E416), guar gum (E412), locust bean gum (E410), beta-glucan, chicle gum, dammar gum, glucomannan (E425), mastic gum, psyllium seed husk, spruce gum, tara gum (E417); natural gums produced by bacterial fermentation: gellan gum (E418), xanthan gum (E415).

[0099] Also included are starch, pectin, carboxymethylcellulose, hydroxypropylcellulose, methylcellulose and gelatin. Cellulose gum is the common name for carboxymethylcellulose, or CMC. Its emulsifying properties make it particularly useful in products that contain ingredients that tend to separate, such as yogurt and jellies. Its ability to bind water makes it particularly useful in diet foods, which tend to substitute water or other liquids for fat. Cellulose gum also improves texture, so it is a common ingredient in products where smoothness is a quality feature, such as ice cream and frosting. Brewers also use cellulose gum to stabilize beer foam. These same properties are useful in some pharmaceutical products that tend to separate over time, such as toothpaste. In the cosmetics industry, cellulose gum is present in bath products, makeup, shaving gels and hair products. According to one embodiment, preferred thickeners include, but are not limited to, xanthan gum, carboxymethylcellulose, and guar gum.

[0100] According to another embodiment, the thickening agent is present in the formulation at approximately from about 0.1% to about 66% (w / w), or from about 0.5% to about 66% (w / w), or from about 1% to about 66% (w / w), 2% to about 66% (w / w), or from about 5% to about 66% (w / w), or from about 10% to about 66% (w / w), or from about 15% to about 66% (w / w), or from about 20% to about 66% (w / w), or from about 25% to about 66% (w / w), or from about 30% to about 66% (w / w), or from about 35% to about 66% (w / w), or from about 40% to about 66% (w / w), or 45% to about 66% (w / w), or about 50% to about 66% (w / w), or about 55% to about 66% (w / w), or about 60% to about 66% (w / w), or about 2% to about 60% (w / w), or about 5% to about 60% (w / w), or about 10% to about 60% (w / w), or about 15% to about 60% (w / w), or about 20% to about 60% (w / w), or about 25% to about 60% (w / w), or about 30% to about 60% (w / w), or about 35% to about 60% (w / w), or about 40% to about 60% (w / w), or about 45% to about 60% (w / w), or about 50% to about 60% (w / w), or about 55% to about 60% (w / w), or about 2% to about 55% (w / w), or about 5% to about 55% (w / w), or about 10% to about 55% (w / w), or about 15% to about 55% (w / w), or about 20% to about 55% (w / w), or about 25% to about 55% (w / w), or about 30% to about 55% (w / w), or about 35% to about 55% (w / w), or about 40% to about 55% (w / w), or about 45% to about 55% (w / w), or about 50% to about 55% (w / w), or about 2% to about 50% (w / w), or about 5% to about 50% (w / w), or about 10% to about 50% (w / w), or about 15% to about 50% (w / w), or about 20% to about 50% (w / w), or about 25% to about 50% (w / w), or about 30% to about 50% (w / w), or about 35% to about 50% (w / w), or about 40% to about 50% (w / w), or about 45% to about 50% (w / w), or about 2% to about 45% (w / w), or about 5% to about 45% (w / w), or about 10% to about 45% (w / w),or about 15% to about 45% (w / w), or about 20% to about 45% (w / w), or about 25% to about 45% (w / w), or about 30% to about 45% (w / w), or about 35% to about 45% (w / w), or about 40% to about 45% (w / w), or about 2% to about 40% (w / w), or about 5% to about 40% (w / w), or about 10% to about 40% (w / w), or about 15% to about 40% (w / w), or about 20% to about 40% (w / w), or about 25% to about 40% (w / w), or about 30% to about 40% (w / w), or about 35% to about 40% (w / w), or about 2% to about 35% (w / w), or about 5% to about 35% (w / w), or about 10% to about 35% (w / w), or about 15% to about 35% (w / w), or about 20% to about 35% (w / w), or about 25% to about 35% (w / w), or about 30% to about 35% (w / w), or about 2% to about 30% (w / w), or about 5% to about 30% (w / w), or about 10% to about 30% (w / w), or about 15% to about 30% (w / w), or about 20% to about 30% (w / w), or or about 25% to about 30% (w / w), or about 2% to about 25% (w / w), or about 5% to about 25% (w / w), or about 10% to about 25% (w / w), or about 15% to about 25% (w / w), or about 20% to about 25% (w / w), or about 2% to about 20% (w / w), or about 5% to about 20% (w / w), or about 10% to about 20% (w / w), or about 15% to about 20% (w / w), or about 2% to about 15% (w / w), or about 5% to about 15% (w / w), or about 10% to about 15% (w / w), or about 2 % to about 10% (w / w), or about 5% to about 10% (w / w), or about 2% to about 5% (w / w), or 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 387, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65,Alternatively, it may be present at 66% (w / w). According to one embodiment, the concentration is about 0.5% (w / w).

[0101] Wetting Agent According to another embodiment, the composition of the present invention may further comprise a humectant. A humectant is a substance used to keep an article moist. When used as a food additive, the humectant has the effect of keeping foodstuffs moist. Humectants are also found in many cosmetics where moisturization is desired, including treatments such as moisturizing hair conditioners, and are also commonly used in body lotions. Examples of humectants include, but are not limited to, propylene glycol, as well as hexylene glycol and butylene glycol, glyceryl triacetate, vinyl alcohol, neoagarobiose, sugar polyols such as glycerol, sorbitol, xylitol and maltitol, polymeric polyols such as polydextrose, polyethylene glycol, polypropylene glycol, and poly(tetramethylene ether) glycol, Quillaja, lactic acid, urea, glycerin, aloe vera gel, MP diol, alpha hydroxy acids such as lactic acid, and honey. According to another embodiment, the preferred humectant may be glycerol, and according to another preferred embodiment, the preferred humectant may be glycerol, xylitol, sorbitol, or a combination thereof.

[0102] According to another embodiment of the invention, the humectant comprises from about 2% to about 45% (w / w), or from about 2% to about 40% (w / w), or from about 2% to about 35% (w / w), or from about 2% to about 30% (w / w), or from about 2% to about 25% (w / w), or from about 2% to about 20% (w / w), or from about 2% to about 15% (w / w), or from about 2% to about 10% (w / w), or from about 2% to about 9% (w / w), or from about 2% to about 8% (w / w), or from about 2% to about 7% (w / w), or from about 2% to about 6% (w / w), or from about 2% to about 5% (w / w), or from about 2% to about 4% (w / w), or about 2% to about 3% (w / w), or about 3% to about 5% (w / w), or about 3% to about 4% (w / w), or about 4% to about 5% (w / w), or about 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%, 43%, 44%, or 45% (w / w).

[0103] emulsifier According to one embodiment, the composition of the present invention may further comprise an emulsifier. An emulsifier is a substance that stabilizes an emulsion by increasing its kinetic stability. According to one embodiment, the emulsifier may be lecithin, vegetable pulp powder (such as citrus pulp powder, baobab pulp powder, mango pulp powder, tomato pulp powder, pumpkin pulp powder, guava pulp powder, papaya pulp powder and beet pulp powder), sodium citrate (e.g., trisodium citrate) and citric acid. A preferred emulsifier is sodium citrate.

[0104] According to another embodiment of the invention, the emulsifier comprises from about 1% to about 10%, or from about 2% to about 10%, or from about 3% to about 10%, or from about 4% to about 10%, or from about 4% to about 9%, or from about 4% to about 8%, or from about 4% to about 7%, or from about 4% to about 6%, or from about 4% to about 5%, or from about 5% to about 10%, or from about 5% to about 9%, or from about 5% to about 8%, or from about 5% to about 7%, or may be about 5% to about 6%, or about 6% to about 10%, or about 6% to about 9%, or about 6% to about 8%, or about 6% to about 7%, or about 7% to about 10%, or about 7% to about 9%, or about 7% to about 8%, or about 8% to about 10%, or about 8% to about 9%, or about 9% to about 10% (w / w), or about 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% (w / w).

[0105] Surfactants According to one embodiment, the composition of the present invention may further comprise a surfactant.Surfactants are often always included in toothpaste and other oral care compositions.For example, toothpaste may contain sodium lauryl sulfate (SLS, also known as sodium dodecyl sulfate, SDS) or related surfactants (cleaning agents).SLS is also found in many other personal care products, such as shampoos, and is mainly a foaming agent that allows toothpaste to be distributed evenly and improves cleansing power.Other suitable surfactants include, but are not limited to, ammonium lauryl sulfate, sodium N-lauryl sarcosinate (also known as sodium sarcosinate and sodium lauryl sarcosinate), and sodium lauryl sulfoacetate.

[0106] Surfactants (cleaning agents) also provide a foam that helps clean the teeth and remove debris. Additionally, lauryl sulfates have significant antibacterial properties and they can penetrate and dissolve plaque.

[0107] According to one embodiment, the surfactant may be about 0.5% to about 3% surfactant, or about 1% to about 3% (w / w), or about 2% to about 3% (w / w), or about 1% to about 2% (w / w), or about 2% to about 3%, or 0.5%, 1%, 2%, 3% (w / w).

[0108] pH Adjustment Agent According to one embodiment, the composition of the present invention may contain a pH adjusting agent. The product pH affects its stability and quality. If the pH is too acidic, demineralization is favored, but if it is too basic, calcareous (tartar) deposits on the teeth may become important. Therefore, the pH is preferably close to a neutral pH, for example, about 6 to about 8, or about 6.5 to about 7.5, or about 6.75 to about 7.25, or about 7.0. The measured pH of the product is close to 6.8, or more specifically 6.78.

[0109] In an embodiment, the pH adjusting agent is an acid or base that, when added to the formulation, stabilizes the pH at a desired level suitable for the oral care product of the present invention. Suitable pH adjusting agents include, but are not limited to, citric acid and its derivatives, phosphoric acid and its derivatives, trisodium phosphate, sodium citrate, lactic acid, and bicarbonate. The pH adjusting agent may be present in an amount of about 0.1% to about 0.28% (w / w) of the composition, or about 0.1% to about 0.25%, or about 0.1% to about 0.2%, or about 0.1% to about 0.15%, or about 0.1% to about 0.12%, or about 0.12% to about 0.28%, or about 0.12% to about 0.25%, or about 0.12% to about 0.2%, or about 0.12% to about 0.15%, or about 0.15% to about 0.28%, or about 0.15% to about 0.25%. %, or about 0.15% to about 0.2%, or about 0.2% to about 0.28%, or about 0.2% to about 0.25%, or about 0.25% to about 0.28% (w / w), or about 0.1%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19%, 0.2%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25%, 0.26%, 0.27%, 0.28%.

[0110] Preservatives According to one embodiment, the composition of the present invention may contain a preservative, which, according to one embodiment, may sometimes act as an active antimicrobial agent, since it has an active role in the use of the composition.

[0111] Microorganisms may feed on humectants and thickeners, and ingredients that limit their growth may be present in toothpaste. Generally, this is achieved by using minimal water and preservatives in the formulation. The most common preservatives in toothpaste are sorbitan sesquioleate derivatives, sodium benzoate, potassium sorbate, and benzoic acid. However, the compositions of the present invention may be formulated with natural ingredients that have preservative properties or non-synthetic versions of common preservatives. Examples of natural products with preservative properties include, but are not limited to, eucalyptus extracts, essential oils with natural antimicrobial properties, such as eucalyptus oil, thyme oil, oregano oil, lemon oil, orange oil, and the like, as well as natural antimicrobial agents that may be contained in these essential oils or supplied as isolated compounds, such as thymol, carvacrol, eugenol, eucalyptol, menthol, and the like. The composition may contain from about 0.2% to about 2% w / w, or from about 0.3% to about 2% w / w, or from about 0.4% to about 2% w / w, or from about 0.5% to about 2% w / w, or from about 0.6% to about 2% w / w, or from about 0.7% to about 2% w / w, or from about 0.8% to about 2% w / w, or from about 0.9% to about 2% w / w, or from about 1% to about 2% w / w, or from about 1.1% to about 2% w / w, or from about 1.2% to about 2% w / w, or from about 1.3% to about 2% w / w, or from about 1.4% to about 2% w / w, or from about 1.5% to about 2% w / w, or from about 1.6% to about 2% w / w, or from about 1.7% to about 2% w / w, or from about 1.8% to about 2% w / w, or about 1.9% to about 2% w / w, or about 0.2% to about 1.9% w / w, or about 0.3% to about 1.9% w / w, or about 0.4% to about 1.9% w / w, or about 0.5% to about 1.9% w / w, or about 0.6% to about 1.9% w / w, or about 0.7% to about 1.9% w / w, or about 0.8% to about 1.9% w / w. / w, or about 0.9% to about 1.9% w / w, or about 1% to about 1.9% w / w, or about 1.1% to about 1.9% w / w, or about 1.2% to about 1.9% w / w, or about 1.3% to about 1.9% w / w, or about 1.4% to about 1.9% w / w, or about 1.5% to about 1.9% w / w, or about 1.6% to about 1.9% w / w, or about 1.7% to about 1.9% w / w, or about 1.8% to about 1.9% w / w, or about 0.2% to about 1.8% w / w, or about 0.3% to about 1.8% w / w, or about 0.4% to about 1.8% w / w, or about 0.5% to about 1.8% w / w, or about 0.6% to about 1.8% w / w, or about 0.7% to about 1.8% w / w, or about 0.8% to about 1.8% w / w, or about 0.9% to about 1.8% w / w, or about 1% to about 1.8% w / w, or about 1.1% to about 1.8% w / w, or about 1.2% to about 1.8% w / w or about 1.3% to about 1.8% w / w, or about 1.4% to about 1.8% w / w, or about 1.5% to about 1.8% w / w, or about 1.6% to about 1.8% w / w, or about 1.7% to about 1.8% w / w, or about 0.2% to about 1.7% w / w, or about 0.3% to about 1.7% w / w, or about 0.4% to about 1.7% w / w, or about 0.5% to about 1.7% w / w, or about 0.6% to about 1.7% w / w, or about 0.7% to about 1.7% w / w, or about 0.8% to about 1.7% w / w, or about 0.9% to about 1.7% w / w, or or about 1% to about 1.7% w / w, or about 1.1% to about 1.7% w / w, or about 1.2% to about 1.7% w / w, or about 1.3% to about 1.7% w / w, or about 1.4% to about 1.7% w / w, or about 1.5% to about 1.7% w / w, or about 1.6% to about 1.7% w / w, or about 0.2% to about 1.6% w / w, or about 0.3% to about 1.6% w / w, or about 0.4% to about 1.6% w / w, or about 0.5% to about 1.6% w / w, or about 0.6% to about 1.6% w / w, or about 0.7% to about 1.6% w / w, or about 0. 8% to about 1.6% w / w, or about 0.9% to about 1.6% w / w, or about 1% to about 1.6% w / w, or about 1.1% to about 1.6% w / w, or about 1.2% to about 1.6% w / w, or about 1.3% to about 1.6% w / w, or about 1.4% to about 1.6% w / w, or about 1.5% to about 1.6% w / w, or about 0.2% to about 1.5% w / w, or about 0.3% to about 1.5% w / w, or about 0.4% to about 1.5% w / w, or about 0.5% to about 1.5% w / w, or about 0.6% to about 1.5% w / w, or about 0.7% to about 1.5% w / w, or about 0.8% to about 1.5% w / w, or about 0.9% to about 1.5% w / w, or about 1% to about 1.5% w / w, or about 1.1% to about 1.5% w / w, or about 1.2% to about 1.5% w / w, or about 1.3% to about 1.5% w / w, or about 1.4% to about 1.5% w / w, or about 0.2% to about 1.4% w / w, or about 0.3% to about 1.4% w / w, or about 0.4% to about 1.4% w / w, or about 0.5% to about 1.4% w / w, or about 0.6% to about 1.4% w / w, or about 0.7% to about 1.4% w / w or about 0.8% to about 1.4% w / w, or about 0.9% to about 1.4% w / w, or about 1% to about 1.4% w / w, or about 1.1% to about 1.4% w / w, or about 1.2% to about 1.4% w / w, or about 1.3% to about 1.4% w / w, or about 0.2% to about 1.3% w / w, or about 0.3% to about 1.3% w / w, or about 0.4% to about 1.3% w / w, or about 0.5% to about 1.3% w / w, or about 0.6% to about 1.3% w / w, or about 0.7% to about 1.3% w / w, or about 0.8% to about 1.3% w / w, or or about 0.9% to about 1.3% w / w, or about 1% to about 1.3% w / w, or about 1.1% to about 1.3% w / w, or about 1.2% to about 1.3% w / w, or about 0.2% to about 1.2% w / w, or about 0.3% to about 1.2% w / w, or about 0.4% to about 1.2% w / w, or about 0.5% to about 1.2% w / w, or about 0.6% to about 1.2% w / w, or about 0.7% to about 1.2% w / w, or about 0.8% to about 1.2% w / w, or about 0.9% to about 1.2% w / w, or about 1% to about 1.2% w / w, or about 1.1 % to about 1.2% w / w, or about 0.2% to about 1.1% w / w, or about 0.3% to about 1.1% w / w, or about 0.4% to about 1.1% w / w, or about 0.5% to about 1.1% w / w, or about 0.6% to about 1.1% w / w, or about 0.7% to about 1.1% w / w, or about 0.8% to about 1.1% w / w, or about 0.9% to about 1.1% w / w, or about 1% to about 1.1% w / w, or about 0.2% to about 1.0% w / w, or about 0.3% to about 1.0% w / w, or about 0.4% to about 1.0% w / w, or about 0.5% to about 1.0% w / w, or about 0.6% to about 1.0% w / w, or about 0.7% to about 1.0% w / w, or about 0.8% to about 1.0% w / w, or about 0.9% to about 1.0% w / w, or about 0.2% to about 0.9% w / w, or about 0.3% to about 0.9% w / w, or about 0.4% to about 0.9% w / w, or about 0.5% to about 0.9% w / w, or about 0.6% to about 0.9% w / w, or about 0.7% to about 0.9% w / w, or about 0.8% to about 0.9% w / w, or about 0.2% to about 0.8% w / w, or about 0.3% to about 0.8% w / w, or about 0.4% to about 0.8% w / w, or about 0.5% to about 0.8% w / w, or about 0.6% to about 0.8% w / w, or about 0.7% to about 0.8% w / w, or about 0.2% to about 0.7% w / w, or about 0.3% to about 0.7% w / w, or about 0.4% to about 0.7% w / w, or about 0.5% about 0.7% w / w, or about 0.6% to about 0.7% w / w, or about 0.2% to about 0.6% w / w, or about 0.3% to about 0.6% w / w, or about 0.4% to about 0.6% w / w, or about 0.5% to about 0.6% w / w, or about 0.2% to about 0.5% w / w, or about 0.3% to about 0.5% w / w, or about 0.4% to about 0.5% w / w, or about 0.2% to about 0.5% w / w, or about 0.3% to about 0.5% w / w The composition may contain about 0.4% to about 0.5% w / w, about 0.2% to about 0.4% w / w, about 0.3% to about 0.4% w / w, or about 0.2% to about 0.3% w / w, or about 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, 2%, and preferably about 0.5% w / w.

[0112] solvent According to another embodiment of the present invention, the composition may include a suitable solvent for formulating the composition, for example, as a mouthwash. Suitable solvents include, but are not limited to, water, ethanol, isopropanol, sorbitol, and glycerol.

[0113] According to one embodiment, the composition comprises from about 40% to about 99% w / w, or from about 45% to about 99% w / w, or from about 50% to about 99% w / w, or from about 55% to about 99% w / w, or from about 60% to about 99% w / w, or from about 65% to about 99% w / w, or from about 70% to about 99% w / w, or from about 75% to about 99% w / w, or from about 80% to about 99% w / w, or from about 85% to about 99% w / w, or from about 90% to about 99% w / w, or from about 95% to about 99% w / w, or from about 40% to about 95% w / w, or from about 45% to about 95% w / w. w, or about 50% to about 95% w / w, or about 55% to about 95% w / w, or about 60% to about 95% w / w, or about 65% to about 95% w / w, or about 70% to about 95% w / w, or about 75% to about 95% w / w, or about 80% to about 95% w / w, or about 85% to about 95% w / w, or about 90% to about 95% w / w, or about 40% to about 90% w / w, or about 45% to about 90% w / w, or about 50% to about 90% w / w, or about 55% to about 90% w / w, or about 60% to about 90% w / w, or about 65% to about 90% w / w, or about 70% to about 90% w / w, or about 75% to about 90% w / w, or about 80% to about 90% w / w, or about 85% to about 90% w / w, or about 40% to about 85% w / w, or about 45% to about 85% w / w, or about 50% to about 85% w / w, or about 55% to about 85% w / w, or about 60% to about 85% w / w, or about 65% to about 85% w / w, or about 70% to about 85% w / w, or about 75% to about 85% w / w, or about 80% to about 85% w / w, or about 40% to about 80% w / w, or about 45% to about 80% w / w, or about 50% to about 80% w / w, or about 55% to about 80% w / w, or about 60% to about 80% w / w, or about 65% to about 80% w / w, or about 70% to about 80% w / w, or about 75% to about 80% w / w, or about 40% to about 75% w / w, or about 45% to about 75% w / w, or about 50% to about 75% w / w, or about 55% to about 75% w / w, or about 60% to about 75% w / w, or about 65% to about 75% w / w, or about 70% to about 75% w / w, or about 40% to about 70% w / w,or about 45% to about 70% w / w, or about 50% to about 70% w / w, or about 55% to about 70% w / w, or about 60% to about 70% w / w, or about 65% to about 70% w / w, or about 40% to about 65% w / w, or about 45% to about 65% w / w, or about 50% to about 65% w / w, or about 55% to about 65% w / w, or about 60% to about 65% w / w, or about 40% to about 60% w / w, or about 45% to about 60% w / w, Alternatively, it may contain about 50% to about 60% w / w, or about 55% to about 60% w / w, or about 40% to about 55% w / w, or about 45% to about 55% w / w, or about 50% to about 55% w / w, or about 40% to about 50% w / w, or about 45% to about 50% w / w, or about 40% to about 45% w / w, or 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% or 99% (w / w).

[0114] Antimicrobial agents Antimicrobial agents useful in the present invention are so-called "natural" antimicrobial active agents. Such antimicrobial agents include natural essential oils and the individual antimicrobial compounds contained in these oils. The names of these active agents are derived from their natural occurrence in plants. Essential oils include oils derived from herbs, flowers, trees, and other plants. Such oils typically exist as small droplets between the cells of plants and can be extracted by several methods known to those skilled in the art, such as steam distillation, enfleurage (i.e., extraction using fat), cold maceration, solvent extraction, or mechanical pressing. Essential oils are typically named by the plant or vegetable in which they are found. For example, rose oil or peppermint oil is obtained from roses or peppermint, respectively.Non-limiting examples of essential oils that can be used in the context of the present invention include anise oil, lemon oil, orange oil, oregano, rosemary oil, wintergreen oil, thyme oil, lavender oil, clove oil, hops, tea tree oil, citronella oil, wheat oil, barley oil, lemongrass oil, cedar leaf oil, cedarwood oil, cinnamon oil, free grass oil, geranium oil, sandalwood oil, violet oil, cranberry oil, eucalyptus oil, verbena oil, peppermint oil, gum benzoin, basil oil, fennel oil, fir oil, balsam oil, menthol, ochume oil, hydatid caladensis oil, barberry oil, rattan oil, and kuru oil. Include coumaronga oil, sesame oil, macadamia nut oil, evening primrose oil, Spanish sage oil, Spanish rosemary oil, coriander oil, thyme oil, pimento berry oil, rose oil, bergamot oil, rosewood oil, chamomile oil, sage oil, clary sage oil, cypress oil, sea fennel oil, frankincense oil, ginger oil, grapefruit oil, jasmine oil, juniper oil, lime oil, mandarin oil, marjoram oil, myrrh oil, neroli oil, patchouli oil, pepper oil, black pepper oil, petitgrain oil, pine oil, rose otto oil, spearmint oil, spikenard oil, vetiver oil, or ylang-ylang.Other essential oils known to those skilled in the art are also contemplated if they are useful within the context of the present invention (e.g., International Cosmetic Ingredient Dictionary, 10th edition, 2004, which is incorporated by reference). This group of essential oils also includes important chemical constituents of plant oils that have been found to provide antimicrobial benefits (eg, antimicrobial phenolic compounds).

[0115] The naturally occurring antimicrobial phenolic compounds as used in the present invention may be synthetically produced by known methods within the capabilities of a skilled artisan or may be obtained from vegetable oil extracts.In one embodiment of the present invention, the naturally occurring phenolic compounds are obtained from plant extracts.In a further embodiment of the present invention, the naturally occurring phenolic compounds are commercially available.In yet a further embodiment of the present invention, the naturally occurring phenolic compounds include carvacrol, thymol, eugenol, eucalyptol, menthol, etc.

[0116] In one embodiment, the disinfectant formulation of the present invention comprises thymol, carvacrol or a mixture thereof. In a further embodiment, the disinfectant formulation of the present invention comprises one or more natural essential oils enriched with thymol, carvacrol or a mixture of thymol and carvacrol.

[0117] The compositions of the present invention may contain from about 0.01% to about 10% (w / w), or from about 0.01% to about 9% (w / w), or from about 0.01% to about 8% (w / w), or from about 0.01% to about 7% (w / w), or from about 0.01% to about 6% (w / w), or from about 0.01% to about 5% (w / w), or from about 0.01% to about 4% (w / w), or from about 0.01% to about 3% (w / w), or from about 0.01% to about 2% (w / w), or from about 0.01% to about 1% (w / w), or from about 0.01% to about 0.75% (w / w), or from about 0.01% to about 0. ... 0.01% to about 0.25% (w / w), or about 0.01% to about 0.10% (w / w), or about 0.10% to about 10% (w / w), or about 0.10% to about 9% (w / w), or about 0.10% to about 8% (w / w), or about 0.10% to about 7% (w / w), or about 0.10% to about 6% (w / w), or about 0.10% to about 5% (w / w), or about 0.10% to about 4% (w / w), or about 0.10% to about 3% (w / w), or about 0.10% to about 2% (w / w), or about 0.10% to about 1% (w / w), or about 0.10% to about 0.75% (w / w) 0.25% to about 10% (w / w), or about 0.25% to about 9% (w / w), or about 0.25% to about 8% (w / w), or about 0.25% to about 7% (w / w), or about 0.25% to about 6% (w / w), or about 0.25% to about 5% (w / w), or about 0.25% to about 4% (w / w), or about 0.25% to about 3% (w / w), or about 0.25% to about 2% (w / w), or about 0.25% to about 1% (w / w), or about 0.25% to about 0 0.75% (w / w), or about 0.25% to about 0.5% (w / w), or about 0.50% to about 10% (w / w), or about 0.50% to about 9% (w / w), or about 0.50% to about 8% (w / w), or about 0.50% to about 7% (w / w), or about 0.50% to about 6% (w / w), or about 0.50% to about 5% (w / w), or about 0.50% to about 4% (w / w), or about 0.50% to about 3% (w / w), or about 0.50% to about 2% (w / w), or about 0.50% to about 1% (w / w), or about 0.50% to about 0.75% (w / w), or about 0.75% to about 10% (w / w), or about 0.75% to about 9% (w / w), or about 0.75% to about 8% (w / w), or about 0.75% to about 7% (w / w), or about 0.75% to about 6% (w / w), or about 0.75% to about 5% (w / w), or about 0.75% to about 4% (w / w), or about 0.75% to about 3% (w / w), or about 0.75% to about 2% (w / w), or about 0.75% to about 1% (w / w), or about 1% to about 10% (w / w), or about 1% to about 9% (w / w), or about 1% to about 8% (w / w) / w), or about 1% to about 7% (w / w), or about 1% to about 6% (w / w), or about 1% to about 5% (w / w), or about 1% to about 4% (w / w), or about 1% to about 3% (w / w), or about 1% to about 2% (w / w), or about 2% to about 10% (w / w), or about 2% to about 9% (w / w), or about 2% to about 8% (w / w), or about 2% to about 7% (w / w), or about 2% to about 6% (w / w), or about 2% to about 5% (w / w), or about 2% to about 4% (w / w), or about 2% to about 3% (w / w), or or about 3% to about 10% (w / w), or about 3% to about 9% (w / w), or about 3% to about 8% (w / w), or about 3% to about 7% (w / w), or about 3% to about 6% (w / w), or about 3% to about 5% (w / w), or about 3% to about 4% (w / w), or about 4% to about 10% (w / w), or about 4% to about 9% (w / w), or about 4% to about 8% (w / w), or about 4% to about 7% (w / w), or about 4% to about 6% (w / w), or about 4% to about 5% (w / w), or about 5% to about 10% (w / w), or about It may contain 5% to about 9% (w / w), or about 5% to about 8% (w / w), or about 5% to about 7% (w / w), or about 5% to about 6% (w / w), or about 6% to about 10% (w / w), or about 6% to about 9% (w / w), or about 6% to about 8% (w / w), or about 6% to about 7% (w / w), or about 7% to about 10% (w / w), or about 7% to about 9% (w / w), or about 7% to about 8% (w / w), or about 8% to about 10% (w / w), or about 8% to about 9% (w / w), or about 9% to about 10% (w / w).

[0118] Flavors and Sweeteners The composition of the present invention may contain a flavor component, which may be orange flavor, apple flavor, grapefruit flavor, pineapple flavor, strawberry flavor, raspberry flavor, cranberry flavor, lime flavor, lemon flavor, grape flavor, peach flavor, any other fruit flavor, vanilla flavor, chocolate flavor, caramel flavor, mint flavor, bubble gum flavor, or any combination thereof.

[0119] Sweeteners such as aspartame, stevia, acesulfame, sucralose, maleic acid, citric acid, saccharin and the like may also be included in the compositions of the present invention.

[0120] Other Ingredients The compositions of the present invention may contain pigments and colorants, such as titanium dioxide or other suitable pigments, such as lactoflavin, chlorophyll, such as copper derivatives of chlorophyll, and other non-active additives, such as hydrogenated castor oil.

[0121] Viscosity of the composition According to one embodiment, the viscosity of the oral care composition of the present invention may be about 17500 to about 35000 cps, preferably 28800 cps, measured in a Brookfield apparatus at 20° C. and 20 rpm. The viscosity of the composition should not prevent good flowability and good rinsing. The product is completely soluble in water.

[0122] Storage stability The stability of the product was measured over a period of 3 months at 20°C and 4°C. The product was placed in an oven and the physical and chemical characteristics were measured, which were comparable to the original values. If it showed no changes in phase separation, color, odor, or precipitate, the product was deemed stable over a period of 2 years in storage.

[0123] Heat stability Heat stability is carried out on the product in an oven at 45°C for 45 days. It is verified that the physical and chemical parameters are the same as the initial values ​​and the product has no phase change, color or odor. The product is deemed stable in hot storage.

[0124] Density measurement The guarantee of good density gives the product a good texture and influences its retention of suspension and stability. The measured value is equal to 1.14, but the desired value is 1.10 to 1.35.

[0125] Process for preparing treated calcium carbonate (CaCO3) particles having reduced or inhibited reaction with fluoride According to one embodiment, there is provided a method for preparing treated calcium carbonate (CaCO) particles having reduced or inhibited reaction with fluoride from a suitable fluoride compound to provide beneficial fluoride treatment to teeth, comprising: a) Crushing aragonite to obtain coarse CaCO3 powder; b) sieving the coarse powder to obtain a first ground CaCO powder having a particle size of about 60 microns to about 75 microns; c) treating the first ground CaC03 powder under weak acidic conditions at a pH of about 4.5 to 5.5 at a temperature and for a time sufficient to demineralize the first ground CaC03 powder to obtain demineralized ground CaC03; d) washing the demineralized ground CaC03 until a neutral pH is achieved; e) Drying the demineralized ground CaCO3 to obtain a calcium carbonate content of greater than 95% (w / w) and about 2.70 to about 3.1 m 2 To obtain treated aragonite calcium carbonate (CaCO3) particles having a specific surface area (SSA) of 100 / g. A method is disclosed that includes:

[0126] In embodiments, the weak acid treatment can be carried out using weak acids such as ammonium chloride, ammonium bromide, ammonium acetate, ammonium carbonate, ammonium phosphate, ammonium formate, ammonium malate, triammonium citrate, ammonium tartrate, acetic acid, citric acid, ascorbic acid, tannic acid, boric acid, lactic acid, formic acid, oxalic acid, uric acid, malic acid, tartaric acid, phosphorous acid, and the like. Stronger acids such as hydrochloric acid and phosphoric acid may be used under dilute conditions resulting in a weak acid treatment of calcium carbonate. The weak acid may be ammonium chloride or ammonium acetate, preferably ammonium chloride.

[0127] The concentration of ammonium chloride may be from about 0.1 M to about 10 M, preferably 1.87 M (10% w / v). In the method of the invention, step c) may be at a pH of about 4.5, about 4.9, or about 4.86.

[0128] In the method of the present invention, step c) may be at a temperature of about 65°C to about 75°C.

[0129] In the method of the present invention, step d) may be in distilled water. In the method of the present invention, step e) may be at about 200°C to about 220°C.

[0130] In the method of the present invention, step e) may be at about 200°C. In the method of the present invention, step e) may last from about 30 minutes to about 60 minutes, for example, about 55 minutes.

[0131] According to one embodiment, the calcium carbonate is calcite, aragonite, vaterite, or a combination thereof. Preferably, the calcium carbonate is aragonite, and most preferably, the aragonite is oolitic aragonite.

[0132] The present invention will be more readily understood by reference to the following examples, which are provided to illustrate the present invention rather than to limit its scope. EXAMPLES

[0133] Preparation of abrasives from oolitic aragonite. The oolitic aragonite sample has a chemical composition according to Table 1 below.

[0134] [Table 1]

[0135] The oolitic aragonite samples are supplied as chips and powdered material with particle size distribution according to Table 2 below.

[0136] [Table 2]

[0137] Table 2 shows that nearly all the chips and powdered material from the aragonite samples were composed of particles having a particle size of 75 μm or larger, since 99–100% were retained on the 200 mesh size screen.

[0138] The raw roe aragonite is stored in a hopper equipped with a screw feeder and later crushed in an ultra-centrifugal rotor mill and sieved through sieves with a cut-off between 55 and 65 μm. At one end, the coarse fraction (65%) leaving the sifter is returned to the feed hopper of the mill for further crushing. At the other end, the fine fraction (which is the raw material for the abrasive formulation) is temporarily stored in the hopper.

[0139] The roe-aragonite powder is then transferred to a double-walled, watertight, sealed reactor equipped with a condenser and vent. First, steam preheated water is mixed with the roe-aragonite powder using a solid-liquid premix pump. This step is to prevent dust generation and clogging of the condenser in the reactor, as well as loss of powder during reactor changeover. Ammonium chloride is then added to the reactor, and the viscosity of the clay is measured at 20°C to be between 400 and 800 centipoise. The mass ratio is measured to be 55% water, 35% aragonite powder, and 10% ammonium chloride (1M). Once this blending is complete, the mixture is heated to a temperature between 80 and 90°C, reacted with stirring until equilibrium (approximately 3-4 hours), and cooled without stirring for approximately 2-3 hours. The reaction mixture is filtered through a basket centrifuge with 55 μm pores and washed with water until a neutral pH is obtained. Finally, the mixture is dried in a tunnel dryer and the treated oolitic aragonite powder is collected at the dryer outlet. A suitable preservative is added and homogenized with the powder in a double cone mixer, then poured into a hopper and packaged in a plastic bag.

[0140] Particle size of cuttlebone powder (CB): Treated cuttlebone powder (TCB), synthetic calcium carbonate (CaCO3), and treated roe aragonite powder were analyzed using a Microtrac Dynamic Image Analysis (DIA) particle size analyzer. The treated roe aragonite sample was dispersed in isopropanol. Sonicated for 1 minute and measured. Referring to FIG. 1 and Table 3 for the roe, it shows that CB has a particle size of about 35.371±3.472 μm, TCB has a particle size of about 78.422±6.441 μm, synthetic calcium carbonate (CaCO3) has a particle size of about 27.550±3.781 μm, and treated roe aragonite has a particle size of about 46.38±19.36 μm.

[0141] [Table 3]

[0142] The TCB, untreated oolitic aragonite, and treated oolitic aragonite were then subjected to Fourier transform infrared spectroscopy (FTIR) analysis. Referring now to Figure 2, this shows the FTIR spectrum of treated oolitic aragonite compared to treated cuttlebone aragonite (TCB) and untreated oolitic aragonite samples. 2- Peaks associated with the ions can be readily identified in each sample. However, the C=O peak identified in the TCB, which is associated with the presence of chitin in the TCB sample, is not present in the treated oolitic aragonite. Indeed, the spectrum of treated oolitic aragonite shows a peak at 1653 cm corresponding to chitin. -1 The absence of C=O bands at

[0143] Referring now to Figure 3, a comparison of treated oolitic aragonite (bottom left) and TCB (top right) is shown. The diffractogram shows that the TCB exhibits a broader band width representing smaller grain size.

[0144] Referring now to Figures 4A to J, SEMs of CB (Figures 4A and 4D), TCB (Figures 4B and 4D), synthetic calcium carbonate (Figures 4C and 4F) and treated oolitic aragonite (Figures 4G, 4H, 4I or 4J) are shown. The SEM micrographs show that CB (Figures 4A and 4D) has a needle-like structure, in contrast to the cubic structure of CaCO3 (Figures 4C and 4F). Treatment of CB to produce TCB increased surface texturing as the needle-like structures became more defined and separated. Treatment of oolitic aragonite to produce treated oolitic aragonite also increased surface texturing, with the surface exhibiting a lumpier, clumpier surface than TCB. Referring now to Figure 4K, EDX analysis shows that the elemental composition of both TCB and oolitic aragonite consists primarily of calcium, carbon and oxygen, comparable to calcium carbonate aragonite, with traces of phosphorus, although oolitic aragonite also has some traces of calcium phosphate. The presence of calcium and phosphorus could be beneficial for teeth.

[0145] Referring now to FIG. 5, the top panel is an SEM of the concretion before reaction with treated oolitic aragonite (left) and after treatment with treated oolitic aragonite (right) at two separate magnifications. The addition of treated oolitic aragonite resulted in a change in appearance, suggesting that a layer of treated oolitic aragonite was deposited on the concretion. Below, in FIG. 5, is an EDX analysis showing the change in the chemical composition of the concretion, specifically the PK, which indicates a decrease in phosphate from the concretion, which was nearly two-fold, and CaK, which may have increased slightly. In FIG. 5, elemental analysis of the calculus before and after exposure to oolitic aragonite reveals a considerable decrease in phosphate content at the expense of increases in calcium and carbon. This is believed to indicate a change in the surface composition of the calculus that favors the formation of calcium carbonate species at the expense of calcium phosphate species. The increase in calcium and decrease in phosphorus content confirm the reaction of the concretion with treated oolitic aragonite.

[0146] The BET specific surface area (SSA) was then determined from a five-point nitrogen adsorption isotherm (Micromeritics Tristar 3000) at 77.3 K from the particles collected on the filter. Approximately 0.5 grams of each sample was degassed in nitrogen overnight at 120° C. (Micromeritics Flow prep 060) and then adsorbed to remove water bound to their surfaces from the humidity in the air.

[0147] Referring to FIG. 6A and Table 4, CB is approximately 4.23±0.15 m 2 / g SSA, TCB is about 5.29±0.06m 2 / g SSA, synthetic calcium carbonate (CaCO3) has been shown to have an SSA of about 0.2380 ± 0.27 and treated oolitic aragonite has an SSA of about 2.8574 ± 0.07.

[0148] [Table 4]

[0149] Next, the crystallinity of triplicate samples of CB, TCB, synthetic calcite powder (CaCO3), oolitic aragonite and treated oolitic aragonite was investigated using X-ray diffraction (XRD), (Bruker AXS GmbH, Karlsruhe, Germany, diffractometer) using a Cu Kα radiation source (λ Kα = 1.5406 Å) operated at 40 kV and 40 mA in the 2θ range of 10-60° in step-scan mode with a step of 0.02° and a count time of 4 seconds per step. As shown in Table 5, the crystallinity (%) of CB was measured to be 22.466 ± 1.050, TCB was 36.4 ± 0.692, calcite CaCO3 was 44.166 ± 0.513, oolitic aragonite (untreated) was 34.033 ± 0.680 and treated oolitic aragonite was 26.133 ± 2.223.

[0150] [Table 5]

[0151] Reference is now made to Figure 7. Brushing tests were then performed on each of the TCB, synthetic calcium carbonate (CaCO3) and treated oolitic aragonite. The abrasivity of the TCB and synthetic calcite powder (i.e., synthetic calcium carbonate) was assessed using a brushing test, where polished resin-embedded enamel / dentin / stone sections were mounted as described in WO2021062554 and mounted on a customized brushing machine (Mach-1, Biomomentum, QC) within a specifically designed mold that exposed only 0.5mm x 15mm of the specimen to the brush. The customized toothbrush was fixed in the machine parallel to the sample surface and the calculus, dentin and enamel sections were brushed in the machine for 56 minutes at 90 strokes / min (5400 cycles) under a load of 500 g using a slurry of TCB, synthetic calcite powder and treated oolitic aragonite in dd-H2O (1:1 (w:w)). This is equivalent to normal tooth brushing twice a day for 2 minutes per session for 2 weeks. The effect of the slurry on calculus removal was determined by measuring the abrasion depth using a stylus profilometer. The abrasion depth was measured using a stylus profilometer (Dektak XT™, Bruker, USA) using the sample surface that did not come into contact with the brush as a baseline. The deepest point in each sample profile was recorded and compared to the baseline. In Figure 7, the samples are, from left to right, TCB, synthetic calcium carbonate and treated oolitic aragonite for each surface tested. The results show that all three slurries have low abrasiveness to enamel, although the treated oolitic aragonite is the most abrasive of the three. Unexpectedly, the treated oolitic aragonite exhibited low abrasiveness to dentin, which is a desirable characteristic, especially considering that it exhibits comparable abrasiveness to TCB to stones. EXAMPLES

[0152] Reaction with stones To investigate the mineral content of stones, stone samples were collected and analyzed at the synchrotron facility by comparing them with pure standards of calcium acetate (CaAc), amorphous calcium phosphate (ACP), α-tricalcium phosphate (α-TCP), β-tricalcium phosphate (β-TCP), dicalcium phosphate dihydrate (DCPD, a form of brushite), octacalcium phosphate (OCP), hydroxyapatite (HA), crystalline hydroxyapatite (CHA), and aragonite (CaCO3).

[0153] Referring now to FIG. 8, the inorganic phases found in the stone samples are shown. Small amounts of amorphous calcium phosphates were identified, as well as significant amounts of α-TCP, DCPD, HA and aragonite. The measured amounts of each of the non-apatitic calcium phosphates in the stone samples were then plotted against the apatitic calcium phosphates [i.e., the sum of hydroxyapatite (HA) and crystalline hydroxyapatite (CHA)] (FIG. 9A), α-TCP vs. DCPD (FIG. 9B), α-TCP vs. aragonite (FIG. 9C), DCPD vs. aragonite (FIG. 9D), DCPD vs. HA (FIG. 9E), α-TCP vs. HA (FIG. 9F), and HA vs. aragonite (FIG. 9G). A very strong correlation was identified between the non-apatitic and apatitic calcium phosphates, suggesting that a link may exist between the abundance of these two calcium phosphate phases and possibly the maturation mechanism between these two. None of the other comparisons between calcium phosphate phases and calcium phosphates yielded significant correlations, suggesting that they could be formed independently.

[0154] Next, to investigate the reaction between the compounds identified in the dental calculus and calcite CaCO3, TCB, or treated oolitic aragonite, equimolar amounts of the compounds were mixed and incubated in or not in HO, and the samples were subjected to Fourier transform infrared spectroscopy (FTIR) analysis. To identify functional groups, a Bruker Tensor 27 Fourier transform infrared (FTIR) spectrometer was used, measuring the wavelengths from 400 to 4000 cm.-1 A collection of 64 scans in a range of 4cm -1 Infrared (IR) spectra of the powder samples were acquired at a resolution of .

[0155] Reference is now made to Figures 10A through 10L. Figures 10A and 10C show that there is no reaction between calcite CaCO3 and brushite DCPD. Figures 10B and 10D show that a reaction occurs between TCB and brushite DCPD. Similarly, Figures 10E and 10G show that a reaction occurs between treated oolitic aragonite and brushite DCPD. Figures 10F and 10H show that there is only a weak reaction between calcite CaCO3 and β-tricalcium phosphate (BTCP). Similarly, Figures 10I and 10K show that only a weak reaction occurs between treated oolitic aragonite and BTCP. Figures 10J and 10L show that only a weak reaction occurs between TCB and BTCP. This experiment helps to explain the mechanism by which oolitic aragonite reacts with dental calculus. The results shown in Figure 10 reveal that calcium carbonate can react with calcium phosphate species found in dental calculus, such as brushite and tricalcium phosphate. And of the two calcium carbonates tested (calcite and aragonite), oolitic aragonite is the most reactive.

[0156] Next, to investigate the reaction between dental calculus and calcite CaCO3 or treated oolitic aragonite, equimolar amounts of the compounds were mixed and incubated in or not in H2O, and samples were subjected to Fourier transform infrared spectroscopy (FTIR) analysis. Now, reference is made to Figures 11A-11D. Figures 11A and 11B show that a reaction occurs between treated oolitic aragonite and calculus. Figures 11C and 11D show that no or very little reaction occurs between calcite CaCO3 and calculus. Overall, Figure 11 demonstrates how oolitic aragonite reacts with dental calculus. The figure shows the reactivity of dental calculus with calcium carbonate. The figure shows the FTIR spectrum of a mixture of dental calculus powder and calcium carbonate powder before and after exposure to water. The results show that after exposure to water, there is a change in the chemical composition of the powder mixture, and this change is more pronounced in the oolitic aragonite / calculus mixture. EXAMPLES

[0157] free CA 2+ and PO4 3- Reactivity of aragonite with The effect of calcium carbonate powders containing aragonite, treated aragonite, and calcite on the precipitation of calcium phosphate [Ca3(PO4)2] was investigated. Briefly, a calcium phosphate supersaturated solution was prepared by adding 15.0 mM CaCl2 and 15.0 mM Na2HPO4 to a covered glass beaker. The pH of the solution was adjusted to 5.60 ± 0.2. After adding 0.5 grams of aragonite, treated aragonite, or synthetic calcite (CaCO3) powder, 1.0 M hydrochloric acid (HCl) (Sigma-Aldrich, USA) was added gradually at 20 °C. After 1 h or 1, 3, 7, 14, and 21 days, the natants were collected by centrifuging the precipitates at 10,000 rpm for 15 min. After drying, XRD and FTIR analyses of these natants were performed. In a parallel experiment, calcium and phosphate ion concentrations were measured after 14 days using inductively coupled plasma atomic emission spectroscopy (ICP-AES; Thermo Scientific iCAP 6500 Dual View, UK). As a control solution, a pure calcium phosphate solution was prepared and stored under the same conditions.

[0158] Figure 12 shows the precipitation of calcium phosphate in the presence of aragonite, treated aragonite, or synthetic calcite (Figure 12A). After 14 days of incubation in a supersaturated solution of calcium phosphate, the FTIR spectra of aragonite, treated aragonite, or synthetic calcite change to show peaks at 1035, 1023, 600, and 560 cm. -1 To PO4 3- The signal for the band is shown (Figure 12A), which indicates that calcium carbonate is converted to free PO4 3- This suggests that it may react with ions and remove them from the surrounding solution.

[0159] Ion concentration in solution (Ca 2+ and PO4 3-The variation of Ca(ions) in calcium phosphate solution was altered after exposure to aragonite, treated aragonite, or synthetic calcite powder (Figures 12B and 12C). Exposure to aragonite, treated aragonite, or synthetic calcite reduced the Ca(ions) in calcium phosphate solution after 14 days of immersion. 2+ While the concentration of PO4 decreased slightly (Fig. 12B), 3- The concentration of ions decreased significantly (Figure 12C). The results also show that the rate of reaction is more rapid with aragonite and treated aragonite than with calcite. With calcite, the concentration decreased between 7 and 14 days, while with aragonite and treated aragonite, no change occurred between 7 and 14 days, indicating that the reaction reached equilibrium sooner. PO4 3- The concentrations of PO43- ions were found to be lower in the aragonite and treated aragonite samples compared to the synthetic calcite, indicating that more PO43- ions were precipitated in the aragonite and treated aragonite than in the calcite. These results suggest that aragonite and treated aragonite act as scavengers for free phosphate. Indeed, these results suggest that aragonite and treated aragonite are able to trap free Ca 2+ and PO4 3- This suggests that aragonite may react with ions and remove them from the aqueous environment. This suggests that aragonite could act as an inhibitor of mineralization and calculus formation. Previous studies on calculus management have focused on calcium chelation, such as the use of pyrophosphate and carboxylate compounds. These molecules prevent calculus deposition but cannot remove calculus. Furthermore, when used in high concentrations, they can cause unwanted demineralization of the teeth. The results presented here indicate a new, unanticipated strategy for managing calculus that focuses on phosphate removal instead of calcium chelation, without damaging the teeth. EXAMPLES

[0160] Formulations containing treated roe-like aragonite A formulation containing TCB as the abrasive was prepared according to the following recipe:

[0161] [Table 6]

[0162] The purpose of the study was to determine the total fluoride (fresh) and total soluble available fluoride (fresh and non-fresh) of five sodium monofluorophosphate dentifrices. For this purpose, the samples were incubated for 90 days at 40°C ± 2°C and 75% ± 5% humidity to simulate normal aging of the product at room temperature over a period of two years. The tests performed were as follows: Total Fluoride Test Tests were performed in triplicate on fresh products. The inside of the Petri dish covers were coated with sodium hydroxide by adding 0.3 ml of 0.25N sodium hydroxide ethanol and evaporating the alcohol under reduced pressure. A 0.25 g sample of each dentifrice (weighed to the nearest 0.001 g) was mixed (1:100) with 25.0 ml of deionized water using a non-aerating mixer. 2.0 ml of each slurry was transferred to the bottom of a Petri dish. 44.0 ml of 70% HClO was added to each Petri dish. A sodium hydroxide-coated lid was immediately placed on top of each slurry in the bottom half of the Petri dish. Each dish was then placed in a 60°C oven overnight.

[0163] After removing the Petri dishes from the oven, the lids were immediately removed. The lids were washed multiple times with several milliliters of deionized water. The wash water was collected in a 25-ml volumetric flask. The volume of each flask was then made up with deionized water. After diluting 1:1 with TISAB II, the solutions were analyzed for fluoride using a fluoride ion specific electrode and a pH / ISE meter. A standard fluoride curve was similarly prepared (hydrolysis and dilution) and used to determine the fluoride content of each of the dentifrice slurries.

[0164] Test for total soluble available fluoride The test was performed in triplicate on fresh products. The inside of the Petri dish covers were coated with sodium hydroxide by adding 0.3 ml of 0.25N sodium hydroxide ethanol and evaporating the alcohol under reduced pressure. A 2.5 g sample of each dentifrice (weighed to the nearest 0.001 g) was mixed with 25.0 ml of deionized water (1:10 dilution) using a non-aerating mixer. Each slurry was then centrifuged at 11,000 g for 8 minutes. 2.0 ml of each supernatant solution was transferred to the bottom of a Petri dish. To each Petri dish, 44.0 ml of 70% HClO was added. A sodium hydroxide-coated lid was immediately placed on top of each slurry in the bottom half of the Petri dish. The dishes were then placed in a 60° C. oven overnight.

[0165] The lids were immediately removed after removing the Petri dishes from the oven. Each lid was washed multiple times with several milliliters of deionized water. The wash water was collected in a 25-ml volumetric flask. The volume of each flask was then made up with deionized water. After 1:1 dilution with TISAB II, these solutions were analyzed for fluoride using a fluoride ion specific electrode and a pH / ISE meter. A standard fluoride curve was similarly prepared (hydrolysis and dilution) and used to determine the fluoride content of the slurries.

[0166] aging The test products are aged for 90 days at 40°±2° and 75%±5% humidity and analyzed again for total soluble available fluorine as described above.

[0167] [Table 7]

[0168] The results show that the dentifrice formulation containing TCB aragonite abrasive exhibits a reduction in bioavailable fluoride of about 50% (52% and 53% remaining for the two controls). The addition of increased concentrations (+0.5%) of sodium bicarbonate only slightly increases the bioavailability of fluoride (about 57%). The addition of tetrasodium pyrophosphate (TSPP) reduced the bioavailability to about 41%, even more than in the control. The use of a mixture of +0.25% bicarbonate and 0.25% TSPP resulted in a bioavailability of 52%, comparable to the control dentifrice composition. Controls 1 and 2 differ in their composition in the hydrated SiO2 thickener / abrasive used. Both Zeodent 165™ and Sylodent SM990T performed equally well.

[0169] Next, taking into consideration the above TCB performance, a new formulation containing treated oolitic aragonite as an abrasive was prepared according to the following recipe for comparison with the TCB formulation:

[0170] [Table 8]

[0171] The purpose of the test was to determine the total fluoride (fresh) and total soluble available fluoride (fresh and non-fresh) of these sodium monofluorophosphate dentifrices. To this end, samples were incubated for 90 days at 40°C ± 2°C and 75% ± 5% humidity to simulate normal aging of the product at room temperature over a period of 2 years. The tests performed are detailed above.

[0172] [Table 9]

[0173] The results show that the dentifrice formulation containing the TCB aragonite abrasive exhibits a greater than 40% reduction in bioavailable fluoride (59% remaining in the TCB sample). The addition of increased concentrations (+0.5%) of sodium bicarbonate increases fluoride bioavailability (approximately 72%). Unexpectedly, the dentifrice formulation containing the treated roe aragonite abrasive exhibits much less reduction in bioavailable fluoride, with only a 19% reduction (81% remaining in the treated roe aragonite sample), a two-fold improvement over the TCB-containing dentifrice. Unexpectedly, the addition of increased concentrations (+0.5%) of sodium bicarbonate increases fluoride bioavailability (approximately 97%); this is close to no reduction in bioavailable fluoride.

[0174] The aging characteristics of these four dentifrices were then evaluated, specifically the viscosity and pH of the samples over periods up to 68 days. Viscosity is an important parameter to monitor in order to estimate the visual and aesthetic appearance of the product as it ages. pH is an important parameter to monitor in order to avoid increases in pH values ​​that are comparable to increases in tartar and calculus formation.

[0175] [Table 10]

[0176] Viscosity and pH values ​​were found to be within accepted parameters for dentifrices.

[0177] The cleaning properties of these four dentifrices were then evaluated using a standard test.

[0178] [Table 11]

[0179] The Pellicle Cleaning Ratio (PCR) test is used to evaluate the stain removal performance of oral care dentifrices such as toothpastes or tooth powders. All results were judged acceptable. The RDA is a test to measure the erosive effect of abrasives in toothpastes on dental dentin. It involves using a standardized abrasive in comparison with the test sample. The determination of this value is done by determining the radioactivity while cleaning abraded dentin that has been radioactively marked by weak neutron irradiation. The value obtained depends on the size, amount and surface structure of the abrasives used in the toothpaste. Values ​​between 0 and 70 represent formulations with low dentin abrasiveness, and values ​​between 70 and 100 represent formulations with moderate dentin abrasiveness. All the formulations tested were judged acceptable. Finally, the relative enamel abrasiveness (REA) was determined. All results were judged acceptable.

[0180] Although preferred embodiments have been described above and illustrated in the accompanying drawings, it will be apparent to those skilled in the art that modifications may be made without departing from the present disclosure, and such modifications are deemed to be possible variations that fall within the scope of the present disclosure.

Claims

1. 1. An oral care composition comprising: a calcium carbonate content of greater than 95% (w / w) from about 2.70 to about 3.1 m for use as a first dental abrasive; ２ Treated aragonite calcium carbonate (CaCO) having a specific surface area (SSA) of 1000 / g. ３ )particle; - a fluoride compound suitable for providing beneficial fluoride treatment to teeth; and Suitable carrier wherein the treated aragonite calcium carbonate particles are effectively treated under mildly acidic conditions to avoid reaction of fluoride from the fluoride compound with the treated aragonite calcium carbonate particles.

2. 10. The oral care composition of claim 1, wherein the treated aragonite calcium carbonate particles have a particle size of from about 25 microns to about 70 microns.

3. 10. The oral care composition of claim 1, wherein the calcium carbonate content is from about 95% to about 99.9% (w / w).

4. The particles are about 2.80 m ２ / g to about 2.9m ２ 10. The oral care composition of claim 1, having a specific surface area of ​​0.1g / g.

5. The treated aragonite calcium carbonate (CaCO ３ 2. The oral care composition of claim 1, wherein the particles are derived from aragonite of plant origin.

6. The oral care composition according to claim 5, wherein the aragonite of plant origin is oolitic aragonite.

7. The fluoride compound is sodium fluoride (NaF), tin fluoride (SnF ２ ), sodium monofluorophosphate (MFP), or a combination thereof.

8. 10. The oral care composition of claim 1, wherein the fluoride compound provides a concentration of fluoride from about 800 ppm to about 5000 ppm or from about 1000 ppm to about 1500 ppm.

9. 10. The oral care composition of claim 1, wherein the treated aragonite calcium carbonate particles are from about 0.100% to about 20% (w / w) of the composition.

10. 10. The oral care composition of claim 1, wherein the particles have a crystallinity of from about 24% to about 28% or about 26%.

11. 10. The oral care composition of claim 1, further comprising a second dental abrasive, a thickener, a humectant, or a combination thereof.

12. The second dental abrasive is selected from the group consisting of colloidal calcium, colloidal silica, hydrous silica, sodium bicarbonate (NaHCO ３ ), aluminum hydroxide (Al(OH) ３ ), calcium carbonate (CaCO ３ ), calcium hydrogen phosphate (CaHPO ４ ・2H ２ O), anhydrous calcium hydrogen phosphate, silica, zeolite, and hydroxyapatite (Ca ５ (P.O. ４ ) ３ OH), or a combination thereof; the thickening agent is natural gum obtained from seaweed; natural gum obtained from non-marine plant sources, natural gum produced by bacterial fermentation, starch, pectin, carboxymethylcellulose, hydroxypropylcellulose, methylcellulose, gelatin, silica, or a combination thereof; and / or 12. The oral care composition of claim 11, wherein the humectant is propylene glycol, hexylene glycol, butylene glycol, glyceryl triacetate, neoagarobiose, sugar polyols, polymeric polyols, quillaja, lactic acid, urea, glycerin, aloe vera gel, MP diol, alpha hydroxy acid, and honey.

13. the natural gum obtained from seaweed is selected from agar (E406), alginic acid (E400), sodium alginate (E401), potassium alginate, ammonium alginate, calcium alginate, carrageenan (E407), or a combination thereof; the natural gum obtained from a non-marine plant source is selected from acacia gum, gum arabic (E414), gum ghatti, gum tragacanth (E413), gum karaya (E416), gum guar (E412), locust bean gum (E410), beta-glucan, chicle gum, gum dammar, glucomannan (E425), mastic gum, psyllium seed husk, spruce gum, tara gum (E417), or combinations thereof; 13. The oral care composition of claim 12, wherein the natural gum produced by bacterial fermentation is selected from gellan gum (E418), xanthan gum (E415), or a combination thereof.

14. the sugar polyol is selected from glycerol, sorbitol, xylitol, maltitol, and combinations thereof; the polymeric polyol is polydextrose, polyethylene glycol, polypropylene glycol, poly(tetramethylene ether) glycol, and combinations thereof; and / or 13. The oral care composition of claim 12, wherein the alpha hydroxy acid is lactic acid.

15. 10. The oral care composition of claim 1, further comprising an emulsifier, a surfactant, a pH adjuster, or a combination thereof.

16. the emulsifier is lecithin, vegetable pulp powder, sodium citrate and citric acid, or a combination thereof; the surfactant is selected from sodium lauryl sulfate, ammonium lauryl sulfate, sodium N-lauryl sarcosinate, sodium lauryl sulfoacetate, or a combination thereof; and / or 16. The oral care composition of claim 15, wherein the pH adjuster is selected from citric acid and its derivatives, phosphoric acid and its derivatives, trisodium phosphate, sodium citrate, lactic acid, bicarbonate, or a combination thereof.

17. 10. The oral care composition of claim 1, further comprising a preservative, a solvent, an antimicrobial agent, or a combination thereof.

18. the preservative is selected from a sorbitan sesquioleate derivative, sodium benzoate, benzoic acid, eucalyptus extract, potassium sorbate, or a combination thereof; the solvent is selected from water, ethanol, isopropanol, sorbitol and glycerol, and / or 18. The oral care composition of claim 17, wherein the antimicrobial agent is selected from natural essential oils, antimicrobial phenolic compounds, or combinations thereof.

19. The treated aragonite calcium carbonate (CaCO ３ 2. The oral care composition of claim 1, wherein the particles are chitin-free.

20. 10. The oral care composition of claim 1 for use in oral hygiene.

21. 10. The oral care composition of claim 1 for use in the removal of stones, for use in the prevention of stone formation, or a combination thereof.

22. Use of the oral care composition described in claim 1 for use in the manufacture of a medicine for oral hygiene.

23. Use of the oral care composition of claim 1 for use in the manufacture of a medicament for the removal of stones, the prevention of stone formation, or a combination thereof.

Images