Multi-lumen tube system for use with endoscopes

Abstract

A multi-lumen insertion tube for use with an endoscope, the endoscope comprising a circumferential outer wall defining a main lumen and a plurality of internal septa dividing the main lumen into a plurality of lumens, the circumferential outer wall expanding radially outward when positive pressure is applied through the insertion tube and at least partially collapsing against at least one of the internal septa when negative pressure is applied through the insertion tube, the at least one internal septa preventing further collapse of the circumferential outer wall.

Description

[Technical field]

[0001] Related Applications This application claims the benefit of priority to U.S. Provisional Patent Application No. 63 / 306,538, filed February 4, 2022, the contents of which are incorporated by reference in their entirety herein. [Background technology]

[0002] The present invention, in some embodiments, relates to a tube system for use with an endoscope, and more particularly, but not exclusively, to a tube system in which the tube is divided into multiple lumens by internal partitions. Summary of the Invention

[0003] In some embodiments, a multi-lumen insertion tube for use with an endoscope is provided, the multi-lumen insertion tube comprising a circumferential outer wall defining a main lumen and a plurality of internal partitions dividing the main lumen into a plurality of lumens, the circumferential outer wall expanding radially outward when positive pressure is applied via the insertion tube and at least partially collapsing against at least one of the internal partitions when negative pressure is applied via the insertion tube, the at least one internal partition preventing further collapse of the circumferential outer wall.

[0004] In some embodiments, at least one of the interior bulkheads defines a triangular wall, and the circumferentially outer wall rests against an apex of the triangular wall upon application of negative pressure via the insertion tube.

[0005] In some embodiments, the triangular walls are formed with wall sections that are sufficiently short so as not to substantially deform under the negative pressure.

[0006] In some embodiments, the circumferentially outer wall is configured to expand radially outward upon application of positive pressure via the insertion tube.

[0007] In some embodiments, the multiple lumens include at least a first lumen and a second lumen, and flow in the first and second lumens is independently controlled.

[0008] In some embodiments, the first inner lumen functions as an irrigation lumen and the second inner lumen functions as an aspiration lumen.

[0009] In some embodiments, the cross-sectional area of ​​the multi-lumen insertion tube is sized for insertion into the colon.

[0010] In some embodiments, the circumferentially outer wall has a thickness of 0.5 mm to 1 mm, and the internal partition has a thickness of 0.3 mm to 0.8 mm.

[0011] In some embodiments, the circumferentially outer wall comprises undulations along at least a portion of the length of the multi-lumen insertion tube.

[0012] In some embodiments, a tubing system is provided for use with an endoscope, the tubing system comprising: a multi-lumen insertion tube configured and dimensioned for insertion into a body cavity; a multi-lumen umbilical tube having multiple lumens and configured to extend outside of the body; and a coupling interface coupling a proximal end of the insertion tube to a distal end of the umbilical tube, the coupling interface configured to fluidly connect the multiple lumens of the insertion tube to the multiple lumens of the umbilical tube.

[0013] In some embodiments, the proximal end of the multi-lumen umbilical tube is configured to connect to a pressure source that provides positive and / or negative pressure.

[0014] In some embodiments, the multi-lumen umbilical tube has a larger cross-sectional area than the multi-lumen insertion tube.

[0015] In some embodiments, the mating interface is formed as a connector having a first portion into which the proximal end of the insertion tube is received and a second portion into which the distal end of the umbilical tube is received.

[0016] In some embodiments, the device further comprises a loop-shaped attachment extending laterally outward from the mating interface for inserting an endoscope.

[0017] In some embodiments, a method is provided for setting up a tubing system for use with an endoscope, the tubing system comprising a multi-lumen insertion tube configured to connect at a proximal end thereof to a multi-lumen umbilical tube, the method including aligning and coupling the multi-lumen insertion tube to an insertion tube of the endoscope, connecting the multi-lumen insertion tube to the multi-lumen umbilical tube via a connector, attaching the connector to the endoscope, and connecting the multi-lumen umbilical tube to a working station of the endoscope.

[0018] In some embodiments, aligning and coupling the multi-lumen insertion tube to the insertion tube of the endoscope includes one or both of holding the distal ends of the endoscope insertion tube and the multi-lumen insertion tube together via a holder and covering the multi-lumen insertion tube and the endoscope insertion tube along their longitudinal directions with a sleeve that holds them together.

[0019] In some embodiments, the step of attaching the connector to an endoscope includes placing a loop-shaped attachment extending from the connector around the endoscope.

[0020] In some embodiments, a method of operating a tube system coupled to a colonoscope with a multi-lumen insertion tube is provided, the method comprising: introducing an insertion tube of the colonoscope into the colon alongside the multi-lumen insertion tube of the tube system; and either suctioning and purging through the multi-lumen insertion tube such that during suction, an internal septum of the multi-lumen insertion tube prevents collapse of the multi-lumen insertion tube, and during purging, an outer wall of the multi-lumen insertion tube expands radially outward.

[0021] In some embodiments, the method further includes removing the colonoscope insertion tube and the multi-lumen insertion tube from the colon, removing the tubing system from the colonoscope insertion tube, and discarding the tubing system.

[0022] In some embodiments, a multi-lumen insertion tube for use with an endoscope is provided, the multi-lumen insertion tube comprising: a circumferential outer wall defining a main lumen; and a plurality of internal partitions dividing the main lumen into a plurality of lumens, wherein along a portion of the length of the insertion tube, the circumferential outer wall is formed with an undulating pattern of ridges and grooves.

[0023] In some embodiments, the ridges and grooves are shaped and dimensioned to provide localized expansion at multiple axial locations along the portion.

[0024] In some embodiments, the portion is more flexible than one or more other longitudinal portions of the insertion tube.

[0025] In some embodiments, the portion is axially aligned with a bendable portion of the endoscope insertion tube when the multi-lumen insertion tube is inserted alongside the endoscope insertion tube.

[0026] Unless otherwise defined, all technical and / or scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this invention belongs.Although methods and materials similar or equivalent to those described herein can be used to practice or test embodiments of this invention, exemplary methods and / or materials are described below.In case of conflict, the patent specification, including definitions, shall prevail.In addition, the materials, methods, and examples are merely illustrative and are not necessarily intended to be limiting.

[0027] Implementation of the method and / or system of the present invention may include performing or completing selected tasks manually, automatically, or a combination thereof. Furthermore, depending on the actual instrumentation and equipment of the method and / or system of the present invention, some selected tasks may be implemented by hardware, software, or firmware, or a combination thereof using an operating system.

[0028] For example, hardware for performing selected tasks in embodiments of the present invention may be implemented as a chip or circuit. As software, selected tasks in embodiments of the present invention may be implemented as a number of software instructions executed by a computer using any suitable operating system. In an exemplary embodiment of the present invention, one or more tasks in exemplary embodiments of the methods and / or systems described herein are performed by a data processor, such as a computing platform for executing a number of instructions. Optionally, the data processor includes volatile memory for storing instructions and / or data, and / or non-volatile storage, such as a magnetic hard disk and / or removable media, for storing instructions and / or data. Optionally, a network connection is also provided. Optionally, a display and / or a user input device, such as a keyboard or mouse, is also provided. [Brief description of the drawings]

[0029] Certain embodiments of the present invention are described herein, by way of example only, with reference to the accompanying drawings, in which it is emphasized that the details shown hereinafter, with particular reference to the drawings, are for the purposes of illustration and for the purpose of detailed description of embodiments of the present invention. Similarly, from viewing the description together with the drawings, it will become apparent to those skilled in the art how embodiments of the present invention may be practiced. [Figure 1] FIG. 1 is a block diagram of a tube system for use with an endoscope according to some embodiments. [Diagram 2] FIG. 2 is a flow chart of a method for setting up and operating a tube system for use with an endoscope (eg, a colonoscope) according to some embodiments. [Figure 3A] FIG. 3A shows a tube system according to some embodiments. [Figure 3B] FIG. 3B shows the tube system attached to a colonoscope, according to some embodiments. [Figure 3C] FIG. 3C illustrates a colonoscope working station and a tube system and colonoscope connected to the tube system working station, according to some embodiments. [Figure 4] FIG. 4 is a cross-sectional view of a multi-lumen insertion tube according to some embodiments. [Figure 5A] FIG. 5A is a cross-sectional view of the multi-lumen insertion tube of FIG. 4 in a resting mode according to some embodiments. [Figure 5B] FIG. 5B is a cross-sectional view of the multi-lumen insertion tube of FIG. 4 in aspiration mode according to some embodiments. [Figure 5C] FIG. 5C is a cross-sectional view of the multi-lumen insertion tube of FIG. 4 in a purge mode according to some embodiments. [Figure 6A] FIG. 6A shows a cross section of a multi-lumen umbilical tube according to some embodiments. [Figure 6B]FIG. 6B shows a cross section of a multi-lumen umbilical tube according to some embodiments. [Figure 6C] FIG. 6C shows a cross section of a multi-lumen umbilical tube according to some embodiments. [Figure 7] FIG. 7 shows a corrugated portion of a multi-lumen insertion tube in some embodiments. [Figure 8A] FIG. 8A is a schematic diagram of a connector for coupling a multi-lumen insertion tube to a multi-lumen umbilical tube and attaching the assembled tube system to an endoscope in some embodiments. [Figure 8B] FIG. 8B is a schematic diagram of a connector for coupling a multi-lumen insertion tube to a multi-lumen umbilical tube and attaching the assembled tube system to an endoscope in some embodiments. [Figure 8C] FIG. 8C is a schematic diagram of a connector for coupling a multi-lumen insertion tube to a multi-lumen umbilical tube and attaching the assembled tube system to an endoscope in some embodiments. [Figure 9A] FIG. 9A is a detailed view of a connector, shown in an open state, for connecting a multi-lumen insertion tube to a multi-lumen umbilical tube and for mounting the assembled tube system onto an endoscope in some embodiments. [Figure 9B] FIG. 9B is a detailed view of a connector, shown in an open state, for connecting a multi-lumen insertion tube to a multi-lumen umbilical tube and for mounting the assembled tube system onto an endoscope in some embodiments. [Figure 9C] FIG. 9C is a detailed view of a connector for connecting a multi-lumen insertion tube to a multi-lumen umbilical tube and for mounting the assembled tube system onto an endoscope, shown in a closed state, in some embodiments. [Figure 9D]FIG. 9D is a detailed view of a connector for connecting a multi-lumen insertion tube to a multi-lumen umbilical tube and for mounting the assembled tube system onto an endoscope, shown in a closed state, in some embodiments. [Figure 10A] FIG. 10A illustrates an alternative cross-sectional shape of a multi-lumen insertion tube in some embodiments. [Figure 10B] FIG. 10B illustrates an alternative cross-sectional shape of a multi-lumen insertion tube in some embodiments. [Figure 10C] FIG. 10C illustrates an alternative cross-sectional shape of a multi-lumen insertion tube in some embodiments. [Figure 10D] FIG. 10D illustrates an alternative cross-sectional shape of a multi-lumen insertion tube in some embodiments. [Figure 10E] FIG. 10E illustrates an alternative cross-sectional shape of a multi-lumen insertion tube in some embodiments. [Figure 11A] FIG. 11A is a perspective view of an endoscope having an adhesive strip for connecting a multi-lumen insertion tube or a multi-lumen umbilical tube according to some embodiments. [Figure 11B] FIG. 11B is a perspective view of an endoscope having an adhesive strip for connecting a multi-lumen insertion tube or a multi-lumen umbilical tube according to some embodiments. [Figure 11C] FIG. 11C is a perspective view of an endoscope having an adhesive strip for connecting a multi-lumen insertion tube or a multi-lumen umbilical tube according to some embodiments. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0030] In some embodiments, the present invention relates to a tube system for use with an endoscope, and more particularly, but not exclusively, to a tube system in which the tube is divided into multiple lumens by an internal partition. Some embodiments relate to a tube system for use with a colonoscope, configured to be inserted at least partially into the colon alongside the colonoscope. For example, a multi-lumen tube can effectively achieve a smaller cross-sectional area compared to using multiple separate smaller tubes. And, unlike the wall of a single lumen in a multiple separate tube configuration, a single inner wall effectively functions as the wall of two lumens. The reduced cross-sectional area can facilitate maneuvering of the tube within a body cavity, for example around a bend. Another advantage is that a multi-lumen tube can be more easily assembled and introduced into a body cavity (compared to the placement of multiple separate smaller tubes).

[0031] A broad aspect of some embodiments relates to reducing or preventing deformation of a tube inserted into a body cavity while maintaining the flexibility of the tube for manipulation, steering, and bending in a narrow body cavity such as the colon. In some embodiments, the reduction / prevention of deformation is achieved by one or more inner walls of the tube arranged to support the outer wall of the tube, as needed, at one or more locations that are prone to deformation, for example, when suction (vacuum) is applied through the tube. In some embodiments, the support provided by the inner walls of the tube allows the outer wall of the tube to be relatively thin, which in turn allows the tube to be flexible and pliable. In some embodiments, each inner wall forms a sufficiently small portion that is less likely (or not) to deform under pressure, such as a vacuum, compared to a longer portion of the outer circumference (outer wall) of the tube that may deform or collapse inwardly under pressure in the absence of support, for example.

[0032] One aspect of some embodiments relates to a multi-lumen insertion tube that can be inserted into a body cavity along with an endoscope, the multi-lumen insertion tube comprising an internal partition that divides the lumen of the tube into multiple (e.g., 2, 3, 4, 5 or more) lumens. In some embodiments, the lumens form an elongated channel that extends along the longitudinal axis of the tube.

[0033] In an exemplary configuration, the inner wall of the tube is configured as a triangle, with the apex of the triangle serving as a point against which the outer wall of the tube rests when, for example, suction is applied through the tube and the outer wall deforms inward. Supporting the outer wall prevents further collapse of the outer wall and maintains an open volume within the tube for continued flow of fluids and / or substances. In some embodiments, support for the outer wall of the tube by the inner wall of the tube is shaped and arranged to maintain the tube open over at least 60%, 70%, 90% or any intermediate or greater or lesser percentage of its cross-sectional area (compared to the tube's resting or uncrushed or undeformed state).

[0034] In some embodiments, the flow in the inner channels of the insertion tube is independently controlled. In some embodiments, the inner channels of a multi-lumen insertion tube have different functions. For example, one channel is used for irrigation and the other channel is used for aspiration (e.g., for draining fluid and / or feces from the colon). In some embodiments, the inner channel may be used to introduce tools and function as an additional working channel to the colonoscope working channel. Examples of tools for insertion through the inner channel include snares, anchors, graspers, marking probes, jaw tools, etc.

[0035] One aspect of some embodiments relates to a tube system for use with an endoscope, the tube system comprising a multi-lumen insertion tube disposed in fluid communication with a multi-lumen umbilical tube. In some embodiments, the insertion tube of the tube system is configured to extend side-by-side with a colonoscope insertion tube, and the umbilical tube of the tube system is configured to extend side-by-side with an umbilical tube of the colonoscope. In some embodiments, each of the lumens of the insertion tube is respectively connected to a corresponding lumen of the umbilical tube.

[0036] In some embodiments, the multi-lumen umbilical tube is connected at its distal end to the proximal end of the multi-lumen insertion tube and at its distal end to a working station (optionally a colonoscope working station). In some embodiments, a pressure source (e.g., a pump, optionally configured at the working station) provides proximally directed pressure and / or distally directed pressure to the tube system. Optionally, different pressures (e.g., magnitudes and / or directions) are provided through different lumens of the tube system.

[0037] In some embodiments, the multi-lumen insertion tube is connected to the multi-lumen umbilical tube via a connector that provides fluid communication between the respective lumens. Alternatively, the insertion tube and the umbilical tube are integrally formed as a single conduit tube. The advantage of connecting the multi-lumen insertion tube to the multi-lumen umbilical tube via a connector is that it can facilitate the attachment (and / or detachment) of the entire tube system to the colonoscope.

[0038] In some embodiments, the insertion tube and the umbilical tube are different in shape, e.g., differing from one another in one or more of the following: overall cross-sectional area, tube stiffness, thickness of the outer and / or inner walls of the tube, etc. As an example, the umbilical tube is stiffer and has a larger cross-sectional area than the insertion section because it extends outside the patient's body. In some embodiments, a connector configured at the attachment between the tubes serves as an interface between the two different tube shapes. An advantage of having a removable connection between the insertion tube and the umbilical tube is that the insertion tube may be partially replaced without replacing the entire tubing line.

[0039] An aspect of some embodiments relates to an insertion tube with a corrugated outer wall along at least a portion of the tube's length. In some embodiments, the corrugated outer wall includes ridges and grooves for localized expansion (e.g., radially outward and / or axially) at multiple axial locations along the corrugations. The effect of the corrugations may be to improve the bending properties of the tube and allow for back bending if necessary. Another effect of the corrugations may be that the localized radial expansion may facilitate removal of blockages, for example, by purging through the tube. For example, the corrugations may allow for localized radial expansion at multiple axial locations, so that blockages can be more easily flushed or flushed if necessary without blocking the entire cross-section of the corrugations. Another effect of the corrugations may be that they may increase flexibility at the site (e.g., relative to non-corrugated sections) while not involving the integration of multiple lumens inside the insertion tube. For example, an outer wavy surface may provide additional flexibility or bendability, yet the lumen is substantially unaffected in terms of its cross-sectional area by an internal bulkhead or the like.

[0040] In some embodiments, when the tube system insertion tube is introduced with the endoscope insertion tube, the undulating portion is axially aligned with at least a portion of the bendable portion of the endoscope insertion tube.

[0041] Before describing at least one embodiment of the invention in detail, it is to be understood that the invention is not necessarily limited in its application to the details of construction and the arrangement of elements and / or methods set forth in the following description and / or illustrated in the drawings and / or examples. The invention is capable of other embodiments and of being practiced or carried out in various ways.

[0042] Referring now to the drawings, FIG. 1 is a block diagram of a tube system for use with an endoscope, according to some embodiments.

[0043] In some embodiments, at least a portion of the tube system is introduced into a body cavity, such as into the GI tract (eg, colon), into the esophagus, into a portion of the stomach, and / or other portions, using an endoscope.

[0044] In some embodiments, the tube system is configured for suction and / or irrigation and / or purging, hi some embodiments, the tube system allows for the removal of material from the body, for example, for cleaning the colon of feces.

[0045] In some embodiments, the tube system 100 comprises a multi-lumen insertion tube 102 that is insertable into a patient's body 106 along with a portion of an endoscope (endoscope insertion tube 104). In some embodiments, the insertion tube 102 is relatively small in diameter and flexible enough to allow manipulation of the tube along with the main endoscope.

[0046] In some embodiments, the insertion tube 102 is comprised of an extruded tube that is internally divided into multiple lumens, e.g., by internal walls or partitions. In some embodiments, the lumens extend axially along the length of the insertion tube. By way of example, the insertion tube 102 is comprised of at least two lumens, three lumens, four lumens, five lumens, or any number in between, more or less. In some embodiments, the lumens have different functions. For example, some lumens are used for irrigation (i.e., to introduce fluids into the colon), while other lumens are used for aspiration (e.g., drawing material and / or bodily fluids out of the colon) and / or purging (e.g., flushing out blockages that have formed in the tube).

[0047] In some embodiments, a portion 114 of the insertion tube 102 is provided with ripples on the outer surface of the tube. In some embodiments, the ripples increase the flexibility of the tube, making it easier to bend and steer.

[0048] In some embodiments, the tube system 100 includes a multi-lumen umbilical tube 108. In some embodiments, the umbilical tube 108 is comprised of an extruded tube that is internally divided into multiple lumens, for example by an internal wall or partition. By way of example, the umbilical tube 108 is comprised of at least two lumens, three lumens, four lumens, five lumens, or any number in between, more or less. In some embodiments, each of the lumens has a different function. For example, some lumens are used for irrigation (i.e., to introduce fluids into the colon), while other lumens are used for aspiration (e.g., drawing material and / or bodily fluids out of the colon) and / or purging (e.g., flushing out any blockages that may have formed in the tube). In some embodiments, the number of lumens in the insertion tube 102 is the same as the number of lumens in the umbilical tube 108. Alternatively, in some embodiments, the number of lumens in the insertion tube 102 is different than the number of lumens in the umbilical tube 108, e.g., an additional lumen extending from the connector 110 to the distal end (i.e., through the insertion tube) or to the proximal end (i.e., through the umbilical tube).

[0049] In some embodiments, the cross-sectional area of ​​the umbilical tube is larger than the cross-sectional area of ​​the insertion tube 102 (possible because the umbilical tube is not introduced into the body). In some embodiments, the outer wall of the umbilical tube 108 is thicker than the outer wall of the insertion tube 102. In some embodiments, the umbilical tube 108 is connected at its proximal end to a tube system working station 116.

[0050] In some embodiments, the umbilical tube 108 is coupled to and proximate the insertion tube 102 by a connector 110. In some embodiments, the connector 110 provides an internal interface for connecting the lumen of the insertion tube 102 with the respective lumen of the umbilical tube 108, thereby providing uninterrupted fluid communication between the lumens.

[0051] In some embodiments, the connector 110 is configured to couple the connected insertion tube 102 and umbilical tube 108 to an endoscope, e.g., the endoscope umbilical tube 112 and / or the endoscope insertion tube 104. In some embodiments, attachment to the endoscope by the connector 110 occurs on the outside of the endoscope and on the outside of the tubes 102, 108. In some embodiments, the connector comprises clips, ties (e.g., Velcro ties), wrapping tape, and / or other means for attaching the tube system external to the endoscope. Optionally, the connector 110 has a shape that allows it to slide relative to the tube system or vice versa in the axial direction of the endoscope.

[0052] In some embodiments, one or more sensors are incorporated into the connector, for example to detect pressure, flow, and / or other parameters within the lumen of the tube system and / or within the lumen of the endoscopic system.

[0053] However, in some embodiments, two separate connectors may be used: one to couple the insertion tube 102 to the umbilical tube 108, and one to couple the tube system to the endoscope.

[0054] In some embodiments, the insertion tube 102 and the endoscope insertion tube 104 are coupled to one another at their tips and optionally along their lengths, for example by an outer sleeve (eg, a nylon sheath).

[0055] In some embodiments, the sleeve is non-uniform, e.g., has openings or portions that do not include material. For example, the sleeve has a mesh, a plurality of elongated stripes, and / or other non-uniform shapes. In one example, the sleeve is formed as a mesh with openings, e.g., with round or rectangular cross-sections. The mesh sleeve provides the advantage of improving the grip of the endoscope(s) and add-on tubes and reducing the sleeve's interference with bending of the endoscope. The mesh sleeve also provides another advantage of reducing the contact surface with the inner wall of the GI tract, e.g., compared to a uniform sleeve, e.g., without radially outward openings.

[0056] In some embodiments, the endoscope tubes (endoscope insertion tube 104, endoscope umbilical tube 112) are connected at their proximal ends to an endoscope working station 118.

[0057] However, in some embodiments, a single work station configured to dually operate the tube system and endoscope may be used.

[0058] FIG. 2 is a flow chart of a method for setting up and operating a tube system for use with an endoscope, according to some embodiments.

[0059] In some embodiments, the tube system is set up prior to the endoscopic procedure, for example, by a doctor, surgeon, nurse, technician, or other qualified individual.

[0060] In some embodiments, the tubing system is removed from the package 200. Optionally, the tubing system is intended for single use (discarded after use).

[0061] In some embodiments, the tube system insertion tube is aligned and coupled to an endoscope (201), e.g., an endoscope insertion tube. In some embodiments, a distal head of the tube system insertion tube is coupled to a distal head of the endoscope insertion tube. Optionally, the head configured at the distal end of the tube system insertion tube head is formed to define a recess (e.g., a basket-shaped recess) that receives the distal head of the endoscope insertion tube.

[0062] In some embodiments, the tube system insertion tube and the endoscope insertion tube are aligned to extend parallel and adjacent to one another along at least a portion of their lengths. In some embodiments, a cover sleeve is pulled over the aligned insertion tubes to hold and protect the two insertion tubes together. In some embodiments, the cover sleeve is attached at its proximal end to a ring member that is pulled to align the insertion tubes with one another and cover the insertion tubes together with the cover sleeve.

[0063] In some embodiments, the tube system insertion tube is connected to the tube system umbilical tube (203), for example, via a connector attached or received at the proximal end of the insertion tube. In some embodiments, the connector fluidly connects the lumen of the insertion tube to the umbilical tube.

[0064] In some embodiments, the tube system (insertion tube and umbilical tube) is coupled to the endoscope (205) using the same and / or different connectors as needed. The tube system can be connected to the endoscope at one or more locations axially along the endoscope, such as, for example, at the endoscope umbilical tube, the endoscope handle, the proximal end of the endoscope insertion tube, and / or other locations. In some embodiments, the tube system tubes are connected such that they are held in alignment adjacent to the endoscope tube.

[0065] In some embodiments, the proximal end of the tube system umbilical tube is connected to a tube system working station (207). In some embodiments, one or more pressure sources (e.g., pumps) in the working station are configured to set and / or modify the pressure in the tube system, for example, to change the direction of the applied pressure (e.g., suction vs. purging) and / or to modify (increase or decrease) the pressure gradient in the tube system.

[0066] In some embodiments, an endoscope (endoscope insertion tube) along with a tube system insertion tube is introduced at least partially into the patient's body (209), for example, into the GI tract.

[0067] During an endoscopic procedure, one or more of the following actions may be performed through the tube system: irrigation (introducing liquids (saline, water, etc.) into the body to clear the view), suction (feces, fluids, and / or other) to remove material from the body, and purging (e.g., applying distal pressure to flush out blockages formed within the tube system and / or at the entrance to the insertion tube (e.g., tissue). In some embodiments, the suction, irrigation, and / or purging actions are performed while changing the cross-sectional shape of the multi-lumen insertion tube of the tube system in response to the action being performed to reduce structural effects on the insertion tube (211). In some embodiments, the tube cross-sectional change may be exemplified by a change (e.g., deformation) of the outer wall portion of the insertion tube and / or the inner bulkhead of the insertion tube. In some embodiments, the outer wall portion and / or the inner bulkhead (or a portion thereof) move between at least a first position and a second position in response to the action being performed, changing the cross-sectional configuration of the insertion tube. In some embodiments, the cross-sectional deformation is temporary, and once the motion is stopped, the outer and inner walls of the insertion tube resiliently return to their initial configuration.

[0068] In some embodiments, flow within the lumen of the tube system is reversibly and / or variably controllable. If desired, drainage flow is controlled to reduce or prevent blockages from occurring during use, reducing the need to interrupt treatment.

[0069] In some embodiments, one or more sensors detect parameters of the flow within the tube system. Optionally, one or more sensors are mounted inside the lumen to detect, for example, flow, flow rate, pressure, volume of material, etc. In some embodiments, one or more sensors are mounted outside the tube system to detect, for example, pressure within the colon.

[0070] 3A-C show, in some embodiments, a tube system (FIG. 3A), a tube system attached to a colonoscope (FIG. 3B), and a tube system and colonoscope connected to a tube system working station and a colonoscope working station, respectively (FIG. 3C).

[0071] In some embodiments, as shown, for example, in FIG. 3A, a tube system 301 includes an insertion tube 303 configured to be at least partially inserted into a patient's body. In some embodiments, a coupling head 305 is attached (optionally integrally attached) to the tip of the insertion tube for coupling the tube system insertion tube to the endoscope insertion tube. In some embodiments, a sleeve 307 (e.g., a sheath formed of a thin material) is attached to the head 305 and sized to cover and hold both the tube system insertion tube and the endoscope insertion tube such that it extends along at least a portion of the length of the insertion tube (e.g., when pulled).

[0072] In some embodiments, the tube system 301 comprises an umbilical tube 309 coupled to the insertion tube 303 by a connector 311. In some embodiments, the umbilical tube 309 extends from the connector (proximate the insertion tube) to an adapter 313 for connecting the tube system umbilical tube to a tube system working station.

[0073] As examples of dimensions of the components of the tube system, the insertion tube 303 has a dimension between 1900 mm and 2500 mm, e.g., 2000 mm, 2150 mm, 2400 mm, or any dimension between or longer or shorter, and the umbilical tube 309 has a dimension between 1800 mm and 2200 mm, e.g., 1900 mm, 2000 mm, 2100 mm, or any dimension between or longer or shorter.

[0074] In some embodiments, a branch 327 extends from the tube system for disposal of waste fluids and / or feces aspirated from the body cavity. In some embodiments, the branch 327 passes through the work station (e.g., through a peristaltic pump above the work station) and opens into a waste bag or canister.

[0075] In some embodiments, a second branch 329 extends from the adapter 313 to mix fluid (e.g., water) with air for irrigation. In some embodiments, the branch 329 passes through a pump in the working station (e.g., through a lower peristaltic pump in the working station) and is connected at its end to a source of fluid (e.g., a fluid bag, canister).

[0076] 3B shows a tube system connected to a colonoscope. In some embodiments, as shown, the tube system insertion tube 303 runs adjacent to and parallel to the colonoscope insertion tube 317. In some embodiments, a double ring member 321 holds the two tubes together. In some embodiments, one ring is attached to the sleeve 307 and configured to pull the sleeve along the length of the insertion tube to cover them, and the other ring is attached to the tube system insertion tube and functions as a clip configured to be clipped to the endoscope insertion tube.

[0077] In some embodiments, the proximal end of the insertion tube 303 extends along, and optionally through, the control handle 319 of the colonoscope, terminating in a connector 311. In some embodiments, the connector 311 couples the tubing system to a colonoscope umbilical tube 323 (a colonoscope umbilical tube that extends from the control handle 319 to an adapter 325 for connecting the colonoscope to a colonoscope working station).

[0078] FIG. 3C shows a tube system and a colonoscope connected to a tube system working station 331 and a colonoscope working station 333, respectively.

[0079] FIG. 4 is a cross-sectional view of a multi-lumen insertion tube of the tube system according to some embodiments.

[0080] In some embodiments, the insertion tube 401 comprises an outer wall 403 that is generally elliptical or partially elliptical in shape. In some embodiments, the outer wall has an elliptical shape along at least 60%, 70%, 80% or any intermediate, greater or lesser percentage of its length, and a straight (linear) shape (see 405) along the remainder of its length.

[0081] In some embodiments, the insertion tube 401 has an internal partition 407 shaped and arranged to divide the volume inside the outer wall 403 into at least two, at least three, at least four, or more separate lumens. In the illustrated example, the internal partition divides the volume into a first lumen 409 and a second lumen 411.

[0082] In some embodiments, the first lumen 409 is used for irrigation and / or other introduction of fluids into the colon. In some embodiments, the second lumen 411 is used for aspirating material (e.g., aspirating feces and / or fluids from the colon) and / or for, for example, purging (e.g., distally) any blockages inside the lumen 411 or for, for example, pushing out any blockages (partial or complete) of the distal opening of the insertion tube 401 by feces, tissue, or otherwise. In some embodiments, purging and aspirating are alternated through lumen 411, for example, by reversing the direction of pressure in the tube, i.e., applying pressure distally during purging and proximally during aspirating.

[0083] In some embodiments, the internal septum 407 is shaped and positioned to support at least a portion of the outer wall 403 of the insertion tube against collapse. As an example, when suction is applied through the second lumen 411, a portion of the outer wall 403 (see portion 413) may flex or bend inwardly as a result of being pulled by the suction. In this case, the septum 407 acts as an outer wall support that prevents the outer wall from collapsing further inward. In some embodiments, the septum 407 is sized and positioned such that when the outer wall portion is bent against the septum, at least 50%, 60%, 80%, 90%, or any intermediate, greater or lesser percentage of the cross section of the second lumen remains open and uncollapsed to allow material to pass therethrough.

[0084] In some embodiments, as shown, the bulkhead 407 has a triangular shape with an inwardly facing apex 415 against which the curved portion of the outer wall 403 can rest. In some embodiments, the apex 415 is substantially rounded.

[0085] In some embodiments, for example, when purging occurs through second lumen 411 , outer wall 403 expands radially outward to increase the cross-sectional area of ​​lumen 411 .

[0086] In some embodiments, the walls forming the insertion tube are relatively thin, e.g., having a thickness of 0.5 mm, 1 mm, 2 mm, 5 mm, or any intermediate or thicker or thinner thickness, which can contribute to the flexibility of the insertion tube and facilitate its passage through narrow and tortuous body cavities (e.g., the digestive tract).

[0087] 5A-5C are cross-sectional views of the multi-lumen insertion tube of FIG. 4 during static, suction, and purge modes, according to some embodiments. FIG. 5A shows the insertion tube 401 in a static mode, e.g., an initial state when no suction or purging is being applied. FIG. 5B shows a portion 413 of the outer wall 403 partially collapsed against the apex 415 of the bulkhead 407, e.g., due to suction applied through the second lumen 411. FIG. 5C shows at least the portion 413 expanding radially outward, increasing the effective cross-sectional area of ​​the second lumen 411. This may occur, e.g., due to purging applied through the second lumen 411. As another example, if an occlusion occurs in the second lumen 411, a portion of the outer wall (e.g., portion 413) may be forced radially outward, allowing surrounding material to continue to flow through the second lumen 411 while avoiding the occlusion.

[0088] 6A-C show various cross sections of a multi-lumen umbilical tube according to several embodiments.

[0089] In some embodiments, for example as shown in FIG 6A, the umbilical tube 601 of the tube system is internally divided into multiple lumens that correspond to the lumens of the insertion tube (e.g. as shown in FIG 4). In some embodiments, the first lumen 603 is coupled to and in fluid communication with the first lumen 409 of the insertion tube, and the second lumen 605 is coupled to and in fluid communication with the second lumen 411 of the insertion tube.

[0090] In some embodiments, the multiple lumens of the insertion tube are coupled to the multiple lumens of the umbilical tube via connectors (not shown in this figure).

[0091] In some embodiments, because the umbilical tube extends only outside the patient's body, the outer wall 607 and / or inner wall 609 forming the umbilical tube's bulkhead may have a greater thickness and stiffness than the walls forming the insertion tube, reducing the risk of the umbilical tube losing its shape. By way of example, the wall of the umbilical tube may have a thickness of 1.2-2 mm, 0.5-3 mm, 1-4 mm, or any intermediate, greater or lesser thickness.

[0092] 6B shows an example of a multi-lumen umbilical tube in which the first lumen 603 includes a round circular shape. The benefits of a round lumen may include easier manufacturing methods and a stiffer structure (defined by the round inner wall 609).

[0093] FIG. 6C shows an example of a multi-lumen umbilical tube in which first lumen 603 is semicircular in shape and defined by inner wall 609 that extends as a straight-shaped partition between opposing sides of outer wall 607.

[0094] In some embodiments, the cross-sectional shape of the umbilical tube is different from the cross-section of the insertion tube because of the different requirements of the umbilical tube. For example, the umbilical tube does not need to be as flexible as the insertion tube or to undergo the same degree of radial expansion as the insertion tube. This allows for the use of an umbilical tube with a thicker wall and a simpler cross-sectional shape.

[0095] FIG. 7 shows a corrugated portion of a multi-lumen insertion tube in some embodiments.

[0096] In some embodiments, the insertion tube 701 of the tube system includes external undulations 703 along a distal portion of the tube, for example, near the distal head 705 of the insertion tube. (In some embodiments, as shown, the head 705 defines a recess 707 that receives the distal end of the endoscope insertion tube.)

[0097] In one example, the axial length 709 of the undulations is in the range of 50-200 mm, e.g., 75 mm, 100 mm, 125 mm, or any intermediate, longer or shorter. In some embodiments, the undulations are spaced a distance 711 from the distal head 705 in the range of 20-80 mm, e.g., 25 mm, 40 mm, 60 mm, or any intermediate, longer or shorter.

[0098] In some embodiments, the ridges and grooves of the corrugations allow for axial expansion and compression to an extent that may facilitate steering and bending of the insertion tube. As an example, the corrugations are configured to allow for full back bending (U-curve). Another effect of the ridges and grooves of the corrugations is that they may allow for localized radial expansion to aid in clearing blockages of the insertion tube section, for example, during purging.

[0099] In some embodiments, the corrugations are manufactured in multiple steps involving controlled pressure and temperature conditions to keep the lumen of the insertion tube in the desired shape without obstruction.

[0100] 8A-C are schematic diagrams of some embodiments of a connector for coupling a multi-lumen insertion tube to a multi-tube umbilical tube and attaching the assembled tube system to an endoscope.

[0101] 8A-B are front and side views of a connector 801 that connects a multi-lumen insertion tube 803 and a multi-lumen umbilical tube of a tube system 805 in some embodiments. In some embodiments, the connector 801 attaches the connected insertion tube and umbilical tube to an endoscope 807, as shown in FIG. 8C.

[0102] In some embodiments, the connector is configured to communicate fluidly between the insertion tube and the umbilical tube. In some embodiments, the connector has an interface that couples the different cross-sectional shapes of the insertion tube and the umbilical tube, for example, a first interior shape of the insertion tube (e.g., as shown in Figures 5A-C) with a second, different interior shape of the umbilical tube (e.g., as shown in Figures 6A-C).

[0103] In some embodiments, the connector 801 is switchable between an open state in which tubes are inserted (and / or otherwise attached) into designated portions 809, 811 of the connector body 812, which are configured on opposing sides of the connector as needed, and a closed state in which the tubes are sealed together and held by the connector and attached to the endoscope as appropriate.

[0104] In some embodiments, the connector 801 includes wings 813 that spread apart in the open state of the connector and close into the body 812 of the connector in the closed state.

[0105] In some embodiments, the connector 801 includes a loop-shaped attachment (eg, a strap) 815 that extends generally perpendicular to the connector body 812 for receiving the endoscope 807 therethrough.

[0106] However, in some embodiments, configurations that do not include a connector are possible. For example, the insertion tube and umbilical tube may be integrally and continuously formed as a single member. If desired, the cross-sectional shape of such an integral tube changes at one or more axial locations along its length (e.g., at the end of the portion that enters the patient's body and at the beginning of the portion that remains outside the patient's body).

[0107] Alternatively, the multi-lumen insertion tube and / or multi-lumen umbilical tube may be coupled to the endoscope by a strip, for example as described herein with reference to Figures 11A-C. The strip may be like a single-sided tape, but may have a backing that covers the adhesive in the package. The backing may be peeled off (like a bandage) to attach the strip to the multi-lumen insertion / umbilical tube. One or more strips may be pre-attached in various locations during the manufacturing process, or the strips may be provided by a user who determines their location along the endoscope and / or multi-lumen insertion / umbilical tube. Because the strips may be very thin and / or fragile, the ends of the strips may be provided with a stiff piece of plastic to assist in wrapping the strip around the endoscope and / or multi-lumen insertion / umbilical tube.

[0108] The strip may be wrapped around the endoscope and / or the multi-lumen insertion / umbilical tube, the endoscope secured to the multi-lumen insertion / umbilical tube, and then the edge of the strip with the hard plastic piece cut. Alternatively, the strip may have holes to facilitate tearing the hard plastic portion. Alternatively, the strip may have a rectangular or oval cross-sectional shape on the backing sheet so that the user can peel the strip from the backing sheet and wrap it around the multi-lumen insertion / umbilical tube and endoscope at various locations. Figures 9A-9D detail the open (Figures 9A-9B) and closed (Figures 9C-9D) positions of a connector 901 for coupling the multi-lumen insertion tube to the multi-lumen umbilical tube and attaching the assembled tube system to an endoscope.

[0109] In some embodiments, the connector 901 comprises a first portion 903 into which the insertion tube 905 is received and a second portion 906 into which the umbilical tube 907 is received. In some embodiments, one portion (e.g., the first portion 903) is a male connector and the second portion (906) is a female connector.

[0110] 9A and 9C, the lumens 909, 911 of the insertion tube are in fluid communication with the lumens 913, 915 of the umbilical tube, respectively. In some embodiments, the lumen 909, which optionally functions as irrigation, is in fluid communication with the lumen 913, which also functions as irrigation, and the lumen 911, which optionally functions as aspiration / exhaust, is in fluid communication with the lumen 915, which also functions as aspiration / exhaust.

[0111] In some embodiments, as shown, for example, in Figures 9B and 9D, the connector includes side wings 917 that extend radially outward from the tube / connector longitudinal axis 919 when the connector is in an open position and are pushed radially inward when the connector is in a closed position to maintain and seal the connection between the insertion tube and the umbilical tube.

[0112] In some embodiments, the endoscope is introduced into a space defined by a loop-shaped attachment 912 that extends transversely to the tube / connector long axis.

[0113] In some embodiments, the interior profile of the connector is formed with smooth walls without surface irregularities such as protrusions, which can reduce or avoid blockages and provide uninterrupted flow at the communication between the insertion tube and the umbilical tube.

[0114] 10A-E show other examples of cross-sectional shapes of multi-lumen insertion tubes according to some embodiments.

[0115] The example of Figure 10A includes a septum wall that divides the cross section of the tube into two generally square lumens 1001 and two round (e.g. circular) lumens 1003 flanking the square lumens. In some embodiments, the square lumens 1001 function as aspiration / drainage and the round lumens 1003 function as irrigation. The square lumens have the advantage of providing a more rigid structure that may reduce the risk of deformation, but at the same time may negatively affect the flexibility of the tube.

[0116] The example of Figure 10B comprises a generally triangular lumen 1005 and a remaining lumen 1007 defined by a generally elliptical outer wall. Optionally, lumen 1005 may function for irrigation, while remaining lumen 1007 may function for aspiration / irrigation.

[0117] The example of FIG. 10C includes two triangular lumens 1009, 1011, optionally of various sizes, optionally positioned opposite one another within an outer lumen 1013 defined by a generally elliptical outer wall.

[0118] 10D is generally similar to that shown in FIGS. 5A-C, but differs in the ratio of inner triangular lumen 1019 to outer lumen 1021 defined by a generally elliptical outer wall. In this example, outer lumen 1021 has a larger cross-sectional area, which may allow for a higher aspiration rate and / or amount of material passing therethrough.

[0119] The example of FIG. 10E includes a lumen 1015 defined by a generally elliptical outer wall and an inner lumen 1017 bounded by a wall having an arcuate portion.

[0120] 11A-C show several embodiments of an endoscope 1100 and various strips for connecting the endoscope to a multi-lumen insertion tube or umbilical tube, although, if desired, strips may be provided on alternating portions of the multi-lumen insertion tube or umbilical tube to connect the multi-lumen insertion tube or umbilical tube to the endoscope.

[0121] 11A-11C show one of each type of strip, any number of strips may be provided at various locations along the endoscope on the endoscope 1100 to attach the multi-lumen insertion / umbilical tube to the endoscope, as desired. Similarly, in some embodiments, at least one strip may be provided at various locations along the endoscope to attach the multi-lumen insertion / umbilical tube to the colonoscope. For example, depending on the type and length of the endoscope / colonoscope, multiple strips, for example 3-10 strips, may be provided evenly spaced along the endoscope / colonoscope. In some embodiments, the strips may be spaced at any suitable interval along the endoscope / colonoscope, for example at a distance ranging from 10-30 cm or any other suitable interval. Alternatively, in some embodiments, the strips may be spaced unevenly along the endoscope / colonoscope. For example, more strips may be provided in a distal region of the endoscope / colonoscope that is generally more flexible than a generally straight proximal portion of the endoscope / colonoscope. For example, the strips can be spaced at various intervals along the endoscope / colonoscope, such as between 5-40 cm, or any other suitable range of intervals. Below, an example of attaching a multi-lumen insertion / umbilical tube to an endoscope is described, however, a multi-lumen insertion / umbilical tube can be attached to a colonoscope as well.

[0122] The use of at least one strip to attach the multi-lumen insertion / umbilical tube to the endoscope also helps prevent kinking of the tube, making it easier to insert the insertion tube / endoscope while preventing the insertion tube from bending away from the endoscope.

[0123] 11A, according to some embodiments, an endoscope 1100 includes a strip 1102 having an elongated shape. The strip may be formed from any suitable material. Suitable materials may be selected from polymers such as polyurethane, polyvinyl chloride, polyester, polyethylene, and polypropylene.

[0124] The strips may be of any length and width suitable for the type of endoscope and insertion tube that they are attached to together, for example, according to some embodiments the strips may be 3-5 cm long and 2-5 cm wide.

[0125] According to some embodiments, the strip 1102 may be pre-loaded onto the endoscope 1100, or according to some embodiments, the strip 1102 may be attached to the endoscope by a user. According to some embodiments, the strip 1102 is preferably disposable.

[0126] The strip 1102 may include a first side 1104 and a second side 1106. According to some embodiments, the strip 1102 may include an adhesive layer 1108 on the second side 1106, with a backing 1110 disposed over the adhesive layer 1108 that is removed when the strip 1102 is attached to an endoscope. The adhesive layer may include any suitable adhesive, such as, for example, an acrylic, or any silicone-based or other medical grade adhesive. The backing may be formed of any suitable material, such as, for example, paper with a polymer coating, such as fluoroplastic, polyurethane, PVC, polyester, polyethylene, polypropylene, and the like.

[0127] The end 1112 of the strip 1102 may include a tab 1114. The tab 1114 may be rigid and function to aid in wrapping the strip 1102 around the endoscope 1100. The strip may include perforations 1116 near the end 1112 to aid a user in holding the strip 1102 and wrapping it around the endoscope. The tab 1114 may be removed by tearing the strip 1102 along the perforations 1116, as described herein. If desired, the strip 1102 may be wrapped and / or glued around a multi-lumen insertion / umbilical tube (not shown) to attach the endoscope 1100.

[0128] According to some embodiments, the endoscope 1100 may include at least one bendable portion, such as, for example, an accordion portion 1118, to facilitate manipulation of the endoscope 1100 through a tortuous body cavity, such as, for example, the colon or small intestine. The accordion portion 1118 may be provided at a distal end of the endoscope 1100, as shown in FIGS. 11A-C, respectively. Alternatively or additionally, the at least one bendable portion may be located at any suitable portion along the endoscope 1100, such as, for example, between strips. Alternatively, according to some embodiments, the accordion portion 1118 may be replaced by any other suitable type of bendable portion.

[0129] 11B illustrates an endoscope 1100 with a strip 1202 according to some embodiments. The strip 1202 has a first side 1204 and a second side 1206 and includes a tab 1214 attached to an end 1212 of the strip 1202. Although the strip 1202 is shown with the tab 1214 attached to the first side 1204 of the strip, the tab may alternatively be attached to the second side 1206 of the strip, if desired. According to some embodiments, the tab 1214 may include an adhesive layer 1208. A backing 1210 may be disposed on the adhesive layer 1208. According to some embodiments, the backing 1210 may be removed before the strip 1202 is attached to the endoscope 1100. If desired, the adhesive layer 1208 may be continuous from the tab 1214 to at least a portion of the second side 1206 of the strip 1202. An adhesive layer 1208 may be disposed on tab 1214 and, optionally, on a second side 1206 of strip 1202 to allow strip 1202 to be wrapped around endoscope 1100 and secured to, for example, a multi-lumen insertion / umbilical tube. Optionally, according to some embodiments, strip 1202 may be wrapped around and / or adhered to a multi-lumen insertion / umbilical tube (not shown) to attach the endoscope.

[0130] 11C illustrates an endoscope 1100 including a strip 1302 according to some embodiments. The strip 1302 includes a first side 1304 and a second side 1306 with an adhesive layer 1308 disposed on at least an end 1312 of the strip 1302. A backing 1310 is disposed over the adhesive layer 1308, which is removed when the strip 1302 is attached to the endoscope 1100. If desired, the strip 1302 may be wrapped around and / or adhered to a multi-lumen insertion / umbilical tube (not shown) for attachment to the endoscope.

[0131] Endoscope 1100 may, according to some embodiments, include a generally tubular covering or sleeve 1120 over accordion portion 1118. Sleeve 1120 may be formed of any suitable material, such as, for example, a polymer. An end of sleeve 1120 may be attached to endoscope 1100 by any suitable method, such as, for example, by welding or adhesive, and extend over accordion portion 1118. The sleeve may be wide enough that the portion of endoscope 1100 adjacent accordion portion 1118 fits inside the sleeve. Sleeve 1120 may have a similar configuration and structure to sleeve 307 (FIG. 3A), except that sleeve 1120 is generally shorter but has a length sufficient to cover accordion portion 1118.

[0132] Placing the sleeve 1120 over the accordion portion 1118 of the endoscope 1100 allows the endoscope to have a smoother exterior surface at the location of the accordion portion, particularly at the location of the accordion portion's ridges 1122. This may facilitate insertion of the endoscope 1100 into a body cavity, such as the colon or small intestine, and may prevent or reduce trauma caused by the ridges 1122 or other portions of the accordion portion 1118 rubbing against tissue in the cavity.

[0133] In the embodiment shown in FIG. 11C, a sleeve 1120 is shown, however, one of ordinary skill in the art will understand that a sleeve may be provided to cover the accordion portion of any of the embodiments described herein, if desired.

[0134] The words "comprises," "comprising," "includes," "including," and "having" and their conjugations mean "including but not limited to."

[0135] The term "consisting of" means "including and limited to."

[0136] The term "consisting essentially of" means that a composition, method, or structure may include additional components, steps, and / or moieties, but only if the additional components, steps, and / or moieties do not materially alter the basic and novel characteristics of the claimed composition, method, or structure.

[0137] As used herein, the singular forms "a," "an," and "the" include the plural unless the context clearly dictates otherwise. For example, "a compound" or "at least one compound" includes a plurality of compounds, and may also include mixtures thereof.

[0138] Throughout this application, various embodiments of the invention may be presented in a range format. It should be understood that the description in range format is merely for convenience and brevity, and is not an inflexible limitation of the scope of the invention. Thus, the description of a range should be considered to specifically disclose all of the possible subranges, as well as each individual numerical value within that range. For example, the description of a range such as 1 to 6 is intended to specifically disclose not only the subranges 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, 3 to 6, etc., but also each individual numerical value within that range, e.g., 1, 2, 3, 4, 5, and 6. This applies regardless of the magnitude of the range.

[0139] Whenever a numerical range is given herein, it is intended to include any recited number (fractional or integer) within the range given. The phrases "range between" a first designated number and a second designated number and "range from" a first designated number to a second designated number are used interchangeably herein and are intended to include the first designated number and the second designated number, and all fractional and integer numbers therebetween.

[0140] As used herein, the term "method" refers to methods, means, techniques, and procedures for accomplishing a given task, including, but not limited to, methods, means, techniques, and procedures known or readily developed from known methods, means, techniques, and procedures by practitioners in the arts of chemistry, pharmacology, biology, biochemistry, and medicine.

[0141] As used herein, the term "treating" includes arresting, substantially inhibiting, slowing, or reversing the progression of a condition, substantially ameliorating the clinical or cosmetic condition of a condition, or substantially preventing the appearance of a clinical or cosmetic condition of a condition.

[0142] It will be understood that certain features of the invention that are, for clarity, described in the context of separate embodiments, may also be provided in a single embodiment in any combination of those features. Conversely, several features of the invention that are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination or with respect to other described embodiments as appropriate. Certain features described in the context of various embodiments should not be construed as essential to that embodiment, unless the particular embodiment is inoperable without that element.

[0143] It is the intention of the applicants that all publications, patents, and patent applications mentioned in this specification are incorporated herein by reference in their entirety to the same extent as if each individual publication, patent, and patent application was specifically and individually incorporated herein by reference. In addition, citation or identification of any reference in this application should not be construed as an admission that such reference is available as prior art to the present invention. Nor should it necessarily be construed as limiting, to the extent that section headings are used. In addition, the priority documents of this application, if any, are incorporated herein by reference in their entirety.

Claims

1. 1. A multi-lumen insertion tube for use with an endoscope, comprising: a circumferential outer wall defining a main lumen; a plurality of internal partitions dividing the main lumen into a plurality of lumens; the circumferentially outer wall expands radially outward when positive pressure is applied through the insertion tube and at least partially collapses against the at least one internal partition when negative pressure is applied through the insertion tube, the at least one internal partition preventing further collapse of the circumferentially outer wall. Multi-lumen insertion tube.

2. The plurality of internal partitions divide the main lumen into a plurality of separate lumen. The multi-lumen insertion tube of claim 1 .

3. at least one said internal partition defines a triangular wall; the circumferentially outer wall abuts against the vertex of the triangular wall when negative pressure is applied via the insertion tube; The multi-lumen insertion tube of claim 1 .

4. the triangular wall is formed with a wall section that is sufficiently short so as not to substantially deform under the negative pressure; The multi-lumen insertion tube of claim 3 .

5. the circumferentially outer wall is configured to expand radially outward upon application of positive pressure via the insertion tube. The multi-lumen insertion tube according to any one of claims 1 to 4.

6. the plurality of lumens includes at least a first lumen and a second lumen; Flow in the first and second lumens is independently controlled. The multi-lumen insertion tube according to any one of claims 1 to 4.

7. The first lumen functions as an irrigation lumen and the second lumen functions as an aspiration lumen. The multi-lumen insertion tube of claim 6.

8. the cross-sectional area of ​​the multi-lumen insertion tube is sized for insertion into the colon; The multi-lumen insertion tube according to any one of claims 1 to 4.

9. The thickness of the circumferential outer wall is 0.5 mm to 1 mm, The thickness of the internal partition is 0.3 mm to 0.8 mm. The multi-lumen insertion tube according to any one of claims 1 to 4.

10. the circumferentially outer wall includes undulations along at least a portion of the length of the multi-lumen insertion tube; The multi-lumen insertion tube according to any one of claims 1 to 4.

11. 1. A tube system for use with an endoscope, comprising: A multi-lumen insertion tube according to any one of claims 1 to 4, configured and dimensioned for insertion into a body cavity; a multi-lumen umbilical tube having multiple lumens and configured to extend outside the body; a coupling interface coupling a proximal end of the insertion tube to a distal end of the umbilical tube, the coupling interface configured to fluidly connect the multiple lumens of the insertion tube to the multiple lumens of the umbilical tube. Tube system.

12. The proximal end of the multi-lumen umbilical tube is configured to connect to a pressure source that provides positive and / or negative pressure.

12. The tube system of claim 11.

13. the multi-lumen umbilical tube has a larger cross-sectional area than the multi-lumen insertion tube; 12. The tube system of claim 11.

14. the coupling interface is formed as a connector having a first portion into which the proximal end of the insertion tube is received and a second portion into which the distal end of the umbilical tube is received.

12. The tube system of claim 11.

15. further comprising a loop-shaped attachment extending laterally outward from the coupling interface for passage of an endoscope therethrough; 12. The tube system of claim 11.

16. at least one adhesive strip; each adhesive strip configured to attach the tube system to an endoscope at a location along the tube system; At said location, at least the adhesive strip is at least partially wrapped around one of the tube system and the endoscope; and / or the adhesive strip is adhered to the other of the tube system and the endoscope; 12. The tube system of claim 11.

17. at least one of the multi-lumen insertion tube and the endoscope includes a bendable portion; the bendable portion includes an outer sleeve configured to lubricate an outer surface of at least one of the multi-lumen insertion tube and the endoscope at the bendable portion.

12. The tube system of claim 11.

18. 1. A method of setting up a tubing system for use with an endoscope, the tubing system comprising a multi-lumen insertion tube configured to connect at a proximal end thereof to a multi-lumen umbilical tube, the method comprising: aligning and coupling the multi-lumen insertion tube to an insertion tube of the endoscope; connecting the multi-lumen insertion tube to the multi-lumen umbilical tube via a connector; attaching the connector to the endoscope; connecting the multi-lumen umbilical tube to a working station of the endoscope. method.

19. The multi-lumen insertion tube has multiple separate lumens.

20. The method of claim 18.

20. The step of aligning and coupling the multi-lumen insertion tube to the insertion tube of the endoscope includes: holding the distal end of the insertion tube and the distal end of the multi-lumen insertion tube of the endoscope together via a holder; covering the multi-lumen insertion tube and the insertion tube of the endoscope along their lengths with a sleeve that holds them together; including one or both of the following:

20. The method of claim 18 or 19.

21. the step of attaching the connector to the endoscope includes placing a loop-shaped attachment extending from the connector around the endoscope; 20. The method of claim 18 or 19.

22. attaching the tube system to the endoscope at at least one location along the tube system; The step of attaching the tube system to the endoscope at each of the locations comprises: wrapping an adhesive strip at least partially around one of the tube system and the endoscope; adhering the adhesive strip to the other of the tube system and the endoscope; including one or both of the following:

20. The method of claim 18 or 19.

23. at least one of the multi-lumen insertion tube and the endoscope includes a bendable portion; the bendable portion includes an outer sleeve configured to lubricate an outer surface of at least one of the multi-lumen insertion tube and the endoscope at the bendable portion.

20. The method of claim 18 or 19.

24. 1. A method of operating a tube system coupled to an endoscope having a multi-lumen insertion tube, comprising: an insertion tube of the endoscope is introduced in juxtaposition with the multi-lumen insertion tube of the tube system; and performing one of suction and purging through the multi-lumen insertion tube such that during suction, an internal septum of the multi-lumen insertion tube prevents the multi-lumen insertion tube from collapsing, and during purging, an outer wall of the multi-lumen insertion tube expands radially outward. method.

25. The multi-lumen insertion tube having multiple separate lumens.

25. The method of claim 24.

26. the insertion tube and the multi-lumen insertion tube of the endoscope are removed; the tube system is separated from the insertion tube of the endoscope; the tubing system is discarded.

26. The method of claim 24 or 25.

27. the tube system being attached to the endoscope at at least one location along the tube system; At each of the positions, the tube system is attached to the endoscope, an adhesive strip wrapped at least partially around one of the tube system and the endoscope; and the adhesive strip is adhered to the other of the tube system and the endoscope; and including one or both of the following:

26. The method of claim 24 or 25.

28. at least one of the multi-lumen insertion tube and the insertion tube of the endoscope includes a bendable portion; the bendable portion includes an outer sleeve configured to smooth an outer surface of at least one of the multi-lumen insertion tube and the insertion tube of the endoscope at the bendable portion.

26. The method of claim 24 or 25.

29. 1. A multi-lumen insertion tube for use with an endoscope, comprising: a circumferential outer wall defining a main lumen; a plurality of internal partitions dividing the main lumen into a plurality of separate lumens; the circumferential outer wall is formed in a wave shape including ridges and grooves along a portion of the length of the insertion tube; Multi-lumen insertion tube.

30. The plurality of internal partitions divide the main lumen into a plurality of separate lumen.

30. The multi-lumen insertion tube of claim 29.

31. the ridges and grooves are shaped and dimensioned to provide localized expansion at multiple axial locations along the portion.

30. The multi-lumen insertion tube of claim 29.

32. the portion being more flexible than one or more other longitudinal portions of the insertion tube; The multi-lumen insertion tube according to any one of claims 29 to 31.

33. the portion is axially aligned with a bendable portion of the insertion tube of the endoscope when the multi-lumen insertion tube is inserted alongside the insertion tube of the endoscope. The multi-lumen insertion tube according to any one of claims 29 to 31.

34. the multi-lumen insertion tube is configured to be inserted alongside an insertion tube of an endoscope; the multi-lumen insertion tube is attached to the insertion tube of the endoscope at at least one location along the multi-lumen insertion tube; At the at least one location, at least an adhesive strip is at least partially wrapped around one of the multi-lumen insertion tube and the insertion tube of the endoscope; and / or the adhesive strip is adhered to the other of the multi-lumen insertion tube and the insertion tube of the endoscope; The multi-lumen insertion tube according to any one of claims 29 to 31.

35. at least one of the multi-lumen insertion tube and the insertion tube of the endoscope includes a bendable portion; the bendable portion includes an outer sleeve configured to smooth an outer surface of at least one of the multi-lumen insertion tube and the insertion tube of the endoscope at the bendable portion.

35. The multi-lumen insertion tube of claim 34.

36. The plurality of internal partitions extend along the entire length of the insertion tube; the plurality of internal partitions dividing the main lumen into a plurality of separate lumens along the length of the insertion tube; The multi-lumen insertion tube according to any one of claims 1 to 4.

37. The plurality of separate lumens includes at least first and second lumens; a first pressure and a second pressure are supplied through the first and second lumens, respectively; the first and second pressures differ in at least one of magnitude and direction; The multi-lumen insertion tube of claim 2 .

38. The multi-lumen insertion tube is configured to be inserted alongside an insertion tube of an endoscope; the multi-lumen insertion tube is attached to the insertion tube of the endoscope at at least one location along the multi-lumen insertion tube; At each of said locations, an adhesive strip at least partially wrapped around one of the multi-lumen insertion tube and the insertion tube of the endoscope; and the adhesive strip is adhered to the other of the multi-lumen insertion tube and the insertion tube of the endoscope; At least one of the following is satisfied: The multi-lumen insertion tube according to any one of claims 1 to 4.

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