Clothing, methods, and uses for photobiomodulation therapy

Abstract

This specification discloses clothing for photobiomodulation therapy having a clothing structure configured to be worn on a user's skin surface with one or more near-infrared light sources integrated into the clothing structure. The near-infrared light sources are configured to emit near-infrared light towards one or more regions of interest of the skin at wavelengths of 600 nm to 1600 nm and at a predetermined dose measurement and duration. A controller having a processor and memory communicates with the near-infrared light sources to control the operating parameters of the near-infrared light sources.

Description

Technical Field

[0001] This patent application claims the benefit of priority of U.S. Provisional Patent Application No. 63 / 272,363, filed Oct. 27, 2021, and U.S. Provisional Patent Application No. 63 / 172,405, filed Apr. 8, 2021, has the right of the filing date thereof, claims the benefit of priority of International Patent Application No. PCT / US2022 / 071626, filed Apr. 8, 2022, has the right of the filing date thereof, this patent application claims the benefit of priority of U.S. Provisional Patent Application No. 63 / 272,363, filed Oct. 27, 2021, and U.S. Provisional Patent Application No. 63 / 172,405, filed Apr. 8, 2021, has the right of the filing date thereof, claims the benefit of priority of U.S. Non-Provisional Patent Application No. 17 / 658,597, filed Apr. 8, 2022, has the right of the filing date thereof, and the entire contents of each of these are hereby incorporated by reference herein.

[0002] The subject matter of this patent application generally relates to devices and methods for treating diseases using photobiomodulation therapy with near-infrared light.

Background Art

[0003] As background, photobiomodulation therapy involves directing near-infrared light towards various parts of a patient's body, such as the skin. Photobiomodulation therapy induces a photochemical reaction within cells, increasing mitochondrial activity and ATP levels. Near-infrared light is adjusted to penetrate the skin, soft tissue, cartilage, cerebrospinal fluid, and bone structures for the purpose of providing treatment for various diseases. In an example of transcranial photobiomodulation therapy, a near-infrared light source is directed towards the head to treat mental health-related symptoms such as stress, fatigue, ADHD, and other psychiatric, neuropsychiatric, and neurodegenerative diseases, and the near-infrared light penetrates the skull and strikes the brain.

[0004] During treatment, one or more light sources must be held in place on the user's skin for an extended period of time. However, the user may wish to continue their daily activities during the treatment period, and there is a need for a portable system that remains in a fixed position during sitting activities and strenuous activities so that the treatment can be accurately achieved without being disrupted. Additionally, the portable system enables immediate real-time use, allowing the user to receive photobiomodulation therapy whenever needed.

[0005] Aspects of the present invention meet these needs and provide additional related advantages described in the following summary. SUMMARY OF THE INVENTION

[0006] Aspects of the present invention teach specific advantages in fabrication and use that result in the exemplary advantages described below.

[0007] This specification discloses photobiomodulation therapy clothing having clothing configured to be worn on a skin surface by a user, in which one or more near-infrared light sources are integrated with the clothing. The near-infrared light sources are configured to emit near-infrared light toward one or more areas of interest on the skin at a wavelength of from about 700 nm to about 1600 nm and at a predetermined dose measurement and duration. A controller having a processor and memory communicates with the near-infrared light sources to control the operating parameters of the near-infrared light sources.

[0008] Other features and advantages of aspects of the present invention will become apparent from the following more detailed description, taken in conjunction with the accompanying drawings that illustrate, by way of example, the principles of aspects of the present invention.

[0009] The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate aspects of the disclosed subject matter in at least one of its exemplary embodiments, as further defined in detail in the following description. Features, elements, and aspects of the present disclosure are referred to by the same numerals in different drawings representing the same, equivalent, or similar features, elements, or aspects according to one or more embodiments. The drawings are not necessarily to scale, and instead, emphasis is placed on showing the principles described herein and provided by way of example of the exemplary embodiments of the invention.

Brief Description of the Drawings

[0010]

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DETAILED DESCRIPTION OF THE INVENTION

[0011]

Table 1

[0012] DETAILED DESCRIPTION The detailed description set forth below in connection with the appended drawings is intended as a description of the embodiments of the invention and is not intended to represent the only form in which the invention may be made and / or utilized. The description sets forth the structures and a series of steps for making and operating the invention in connection with the illustrated embodiments. However, it should be understood that the same or equivalent structures and steps may be achieved by different embodiments that are also intended to be encompassed within the spirit and scope of the invention.

[0013] In one or more embodiments, the present system provides clothing for photobiomodulation therapy that is configured to be worn by a user like other clothing items, allowing for complete mobility and freedom of movement. The clothing for photobiomodulation therapy disclosed herein comprises clothing configured to be worn on the skin surface by a user, integrating one or more photobiomodulation units configured to cooperate with a controller to perform photobiomodulation therapy. The photobiomodulation unit includes one or more near-infrared light sources, one or more sensors, and optionally, one or more stimulation devices electrically connected to connection terminals. The connection terminals are also configured to operably receive the controller to establish an electrical connection. Each of the one or more near-infrared light sources disclosed herein is configured to emit near-infrared light having a wavelength of 600 nm to 1600 nm, as well as a predetermined dose measurement and duration. The controller disclosed herein has a processor and a memory and is configured to control the operating parameters of the near-infrared light source. During operation, the photobiomodulation unit is configured to emit near-infrared light to one or more regions of the user's head or body. In some embodiments, as shown in FIGS. 1 to 31, the clothing 20 for photobiomodulation therapy comprises clothing 30, a photobiomodulation unit 100, and a controller 200.

[0014] In some embodiments, as shown in FIG. 2, the photobiomodulation therapy garment 20 can be configured as a photobiomodulation therapy headband 22 for the purpose of treating a specific region of the head H of a person P using transcranial photobiomodulation therapy. In this configuration, the person P wears the photobiomodulation therapy headband 22 by snugly wrapping it around the head region H such that one or more near-infrared light sources disclosed herein integrated into the photobiomodulation therapy headband 22 are positioned over and / or directed towards the region of interest on the skin surface S to send near-infrared light at a therapeutic level to the region of interest. In some embodiments, in the arrangement of the photobiomodulation therapy headband 22 as shown in FIG. 2, one or more near-infrared light sources disclosed herein are placed over the frontal bone region of the skull of the person P, approximately and / or substantially centered on the median sagittal plane 320 (e.g., centered on the nose), for the purpose of delivering near-infrared light through the skull to the brain region of the person P for treating a disease. Further, in these embodiments, the photobiomodulation therapy headband 22 is arranged such that at least one of the near-infrared light sources disclosed herein integrated within the photobiomodulation therapy headband 22 is placed above the supraorbital ridge region 322 (i.e., the brownish ridge above the eye socket) and generally below the hairline (although the hairline may vary somewhat from person to person). At least in one or more embodiments, at least one of the near-infrared light sources disclosed herein integrated within the photobiomodulation therapy headband 22 should be placed above the supraorbital ridge region 322 or at least above the eye socket to minimize exposure of the eyes to near-infrared light. In some embodiments, as shown in FIG. 2, the photobiomodulation therapy headband 22 is arranged to cover a predetermined region of interest on the skin surface S that includes one or more or all of the Fp1 site 300, Fpz site 302, Fp2 site 304, F3 site 306, Fz site 308, and F4 site 310 when the photobiomodulation therapy headband 22 is worn and properly positioned on the head H.

[0015] The clothing 20 for photobiomodulation therapy, which is shown as the headband 22 for photobiomodulation therapy in FIGS. 1 to 31, can be made to be worn on various body parts. In some embodiments, the clothing for photobiomodulation therapy disclosed herein can be configured to wrap around or conform to various body parts while having the function of moving from one area of interest on the body to another area of interest. In some embodiments, the clothing for photobiomodulation therapy disclosed herein can be specifically configured to fit a particular body part, such as a head covering, a visor, a neck wrap, a shoulder wrap, a wrist wrap, or an abdominal wrap. In some embodiments, the clothing for photobiomodulation therapy disclosed herein can be configured to fit various body parts of an individual while having the function of being worn by the individual, such as a hat, a shirt, pants, or underwear.

[0016] The clothing 20 for photobiomodulation therapy comprises clothing. The clothing can be made flexible, semi-rigid, or rigid, is made to be comfortable for the user's body, and is configured to function like a clothing item or other wearable fashion accessory. In some embodiments, the clothing disclosed herein is a fabric material made by weaving, knitting, fibrillation, shrink filling, sewing, crocheting, or adhesion. In some embodiments, the clothing is composed of multiple layers of fabric material. For example, in some embodiments, the clothing for photobiomodulation therapy comprises an outer fabric sheet and an inner fabric sheet. The outer fabric sheet is sized and dimensioned to function as a base for attaching one or more of the photobiomodulation units and controllers disclosed herein, while the inner fabric assembly is sized and dimensioned to at least cover one or more photobiomodulation units.

[0017] For example, in some embodiments, referring to FIGS. 3, 5-9, 16-20, and 22-24, the photobiomodulation therapy headband 22 includes a garment 30 including an outer fabric sheet 40 and an inner fabric sheet 70, and a photobiomodulation unit 100 sandwiched between the outer fabric sheet 40 and the inner fabric sheet 70. The outer fabric sheet 40 can be made of a variety of natural or synthetic textiles generally selected for aesthetic and / or protective qualities. The inner fabric sheet 70 is configured to contact the skin surface S and can be made of a natural or synthetic textile or other material comfortable for the skin surface S such as spacer cotton. As shown in FIGS. 3-8, the upper and lower portions of the outer fabric sheet 40 and the inner fabric sheet 70 are attached to each other to form the upper edge 50 and the lower edge 52 of the garment 30 so as to surround the photobiomodulation unit 100 therein.

[0018] As shown in FIGS. 3-9, 16-20, and 22-24, the outer fabric sheet 40 of the garment 30 also includes a right head strap 64 extending longitudinally from the right side portion 54 of the garment 30 and a left head strap 66 extending longitudinally from the left side portion 56 of the garment 30. A slide buckle 60 enables adjustment of the length of the right head strap 64, and a slide buckle 62 is connected to the right head strap 64 and held to the right head strap 64 via a loop formed by the slide buckle 60. The slide buckle 62 is configured to receive the free end of the left head strap 66, and the left head strap 66 can include a hook and loop coupling portion for achieving the connection. This head strap arrangement enables easy adjustment of the photobiomodulation therapy headband 22 and secure attachment to the head H.

[0019] As shown in FIGS. 9, 20, and 24, the outer fabric sheet 40 of the garment 30 includes a terminal rail mount opening 58 sized and dimensioned to receive the terminal rail of the connection terminals disclosed herein to enable proper engagement of the controller 200 to the terminal rail. Referring to FIGS. 3, 5-9, 16-20, and 22-24, the outer fabric sheet 40 of the garment 30 also includes a controller strap 68 extending from the left side portion 56 of the garment 30. The controller strap 68 is configured to wrap around the controller 200 once the controller 200 is operably engaged to the photobiomodulation unit 100 to securely hold the controller 200 against the outer fabric sheet 40. The controller strap 68 has a first end securely attached to the garment 30 and a second end opposite the first end that can encircle the perimeter of the attached controller 200, thereby reversibly securing the controller 200 to the garment 30 using, for example, a hook-and-loop fastener, buckle, or snap. The controller strap 68 can be constructed from a non-elastic or elastic material.

[0020] As best seen in FIGS. 9, 16, 17, 20, and 24, the inner fabric sheet 70 of the garment 30 includes one or more near-infrared light source openings 76 and one or more sensor openings 78. Each of the one or more near-infrared light source openings 76 is a notch disposed in the inner fabric sheet 70 and aligned with the near-infrared light sources disclosed herein such that when assembled, each opening 76 allows light from the near-infrared light source to be radiated through the near-infrared light source opening 76. Similarly, each of the one or more sensor openings 78 is a notch disposed in the inner fabric sheet 70 and aligned with the sensors disclosed herein such that when assembled, each opening 78 allows the sensor to function properly and collect information from the user through the sensor opening 78.

[0021] In some embodiments, referring to FIGS. 3-5, 9, 18, 20, 22, and 23, the inner fabric sheet 70 can include one or more sensor covers 79. Each sensor cover 79 is disposed to cover and protect each of the one or more sensors disclosed herein that are attached to the photobiomodulation unit 100. Additionally, each of the one or more sensor covers 79 is configured to contact or be disposed in proximity to the skin surface S when the photobiomodulation therapy garment 20 is worn. Each sensor cover 79 can be attached to the inner fabric sheet 70 or the photobiomodulation unit 100 and / or can be sandwiched therebetween. Each sensor cover 79 is made of a thin sheet of PVC in this exemplary embodiment, which allows one or more sensors disposed thereunder to interact with the skin surface S to measure body functions such as one or more of temperature, heart rate, blood oxygen concentration, and other measurable functions. Further, each sensor cover 79 provides a visible reference to assist the user in positioning and wearing the photobiomodulation therapy garment 20 in the proper orientation. For example, when positioning the photobiomodulation therapy headband 22 around the head H, the one or more sensor covers 79 can be aligned with the nose by hand and the sensor cover 79 can be disposed substantially on the sagittal plane 320.

[0022] The clothing 20 for photobiomodulation therapy also includes a photobiomodulation unit. The photobiomodulation unit includes connection terminals, one or more near-infrared light sources, and one or more sensors, and is configured to establish electronic communication with the controller 200. In some embodiments, referring to FIGS. 9, 10, 12-15, 20, 21, 24, and 25, the photobiomodulation unit 100 includes connection terminals 160, one or more near-infrared light sources 170 such as infrared light, low-level lasers, and / or light emitted diodes (LEDs), one or more sensors 180, and optionally one or more stimulation devices 194, and includes a flexible printed circuit board assembly 110 that provides a flexible substrate that houses an electrical circuit for establishing electronic communication therebetween. The connection terminals 160 (generally rigid or semi-rigid) include an electronic circuit connector 162 mounted thereon, and the electronic circuit connector 162 is configured to provide electronic communication between the controller 200 and the flexible printed circuit board assembly 110. In these embodiments, the flexible printed circuit board assembly 110 is configured to provide flexibility and comfort to the wearer. For example, since the headband 22 for photobiomodulation therapy must closely conform to the contour of the forehead, the flexible printed circuit board assembly 110 is designed to have strategic cutouts to allow for maximum flexibility and comfort. In some embodiments, as shown in FIGS. 8 and 10, the flexible printed circuit board assembly 110 includes a heat dissipation material 102 on the flexible substrate on the side opposite the electrical circuit to dissipate heat generated by the flexible printed circuit board assembly 110 during operation of the clothing 20 for photobiomodulation therapy.

[0023] In some embodiments, referring to FIGS. 10, 12-15, 21, and 25, the flexible printed circuit board assembly 110 includes a first surface and a second surface opposite the first surface, and is a thin, flat substrate configured as a main strip 112 that extends from the connection terminal 160 and bifurcates at the root portion 113 into a first strip 114, a second strip 116, and a sensor strip 140 extending from the center. The first strip 114 and the second strip 116 are distally connected by a connection portion 117 and together define the boundaries of all the notches 118. The first strip 114 and the second strip 116 include the electronic circuitry necessary to establish electronic communication between each near-infrared light source 170 operably attached to the first strip 114 or the second strip 116 and the connection terminal 160.

[0024] In some embodiments, the first strip 114 and the second strip 116 each include a series of tabs extending laterally outward therefrom for attaching the near-infrared light sources disclosed herein thereto. For example, as shown in FIGS. 10 and 12, the first strip 114 includes a first attachment portion 120, a second attachment portion 122, and a third attachment portion 124, where the first attachment portion 120 is separated from the second attachment portion 122 by a first notch 121 therebetween, and the third attachment portion 124 is separated from the second attachment portion 122 by a second notch 123 therebetween. Similarly, the second strip 116 includes a first attachment portion 130, a second attachment portion 132, and a third attachment portion 134, where the first attachment portion 130 is separated from the second attachment portion 132 by a first notch 131 therebetween, and the third attachment portion 134 is separated from the second attachment portion 132 by a second notch 133 therebetween. The first attachment portion 120, the second attachment portion 122, the third attachment portion 124 of the first strip 114 and the first attachment portion 130, the second attachment portion 132, the third attachment portion 134 of the second strip 116 function like a gore that allows independent flexible bending of the flexible printed circuit board assembly 110. Such flexible bending enables the flexible printed circuit board assembly 110 to easily conform to the contours of one or more regions of interest of the skin region S, and each of the one or more near-infrared light sources disclosed herein is positioned proximate to the skin surface S with minimal or no gap.

[0025] In some embodiments, referring to FIGS. 10, 12-15, 21, and 25, sensor strip 140 includes a sensor attachment portion 142 and a free end 144. Sensor strip 140 extends from root portion 113 into notch 118 such that notch 118 provides a gap for sensor strip 140 between first strip 114 and second strip 116, and sensor strip 140 is separated from first strip 114 and second strip 116 except at root portion 113. Sensor strip 140 includes the electronic circuitry necessary to establish electronic communication between each sensor 180 operably attached to sensor strip 140 and connection terminals 160. Sensor strip 140 is relatively thin and elongated to allow for curvature and slight movement of sensor strip 140 relative to the remainder of flexible printed circuit board assembly 110, which is further enabled by sensor opening 254 provided by double-sided tape 250 (see FIGS. 9, 16, 17, 20, and 24), which allows for easy curvature and fit around head H with little or no twisting of flexible printed circuit board assembly 110.

[0026] In some embodiments, referring to FIGS. 20, 21, 24, and 25, the photobiomodulation unit 100 includes a flexible printed circuit board assembly 110 that provides a flexible substrate for housing an electrical circuit that establishes electronic communication between a connection terminal 160 and one or more near-infrared light sources 170, such as infrared light, low-level lasers, and / or light-emitting diodes (LEDs), one or more sensors 180, and one or more stimulation devices 194, such as a transcranial direct current stimulation device or a transcranial magnetic stimulation device. The connection terminal 160 (generally rigid or semi-rigid) includes an electronic circuit connector 162 mounted thereon, and the electronic circuit connector 162 is configured to provide electronic communication between the controller 200 and the flexible printed circuit board assembly 110. In these embodiments, the flexible printed circuit board assembly 110 is configured to provide flexibility and comfort to the wearer. For example, since the headband 22 for photobiomodulation therapy must closely conform to the contour of the forehead, the flexible printed circuit board assembly 110 is designed to have strategic cutouts to allow for maximum flexibility and comfort.

[0027] In one embodiment, referring to FIGS. 6, 9, 10, 12-17, 19-21, and 23-25, a connection terminal 160 is integrally attached to one end of the flexible printed circuit board assembly 110. The connection terminal 160 includes an electronic circuit connector 162 and a terminal rail mount 164. The electronic circuit connector 162 of the connection terminal 160 is disposed on the surface of the flexible printed circuit board assembly 110 where one or more infrared light sources 170, one or more sensors 180, and one or more stimulation devices 194 are attached, and includes an electrical circuit used to establish electronic communication with the one or more infrared light sources 170, the one or more sensors 180, and the one or more stimulation devices 194. The terminal rail mount 164 of the connection terminal 160 is disposed on the surface of the flexible printed circuit board assembly 110 opposite to the surface where the electronic circuit connector 162 is located. The terminal rail mount 164 includes a plurality of contacts 166. The terminal rail mount 164 is configured to receive the controller 200 and establish electronic communication between the photobiomodulation unit 100 and the controller 200 having corresponding contacts that couple with the contacts 166 when connected. To enable quick connection and disconnection, the controller 200 and the terminal rail mount 164 include a sliding joint (e.g., a joint such as a dovetail or tongue and groove joint) for capturing the controller 200 within the terminal rail mount 164 and forcing electrical contact between the contacts 166 of the terminal rail mount 164 and the corresponding contacts protruding through the controller 200. After sliding the controller 200 into the terminal rail mount 164, a controller strap 68 is wrapped around the controller 200 and fixed to the inner portion 44 of the outer fabric sheet 40 by a releasable connection such as a hook and loop.

[0028] In some embodiments, referring to FIGS. 16 and 17, the photobiomodulation unit 100 includes a liquid wire circuit assembly 150 that provides electronic communication between a connection terminal 160, one or more near-infrared light sources 170 such as, for example, infrared light, low-level lasers, and / or light-emitting diodes (LEDs), one or more sensors 180, and optionally one or more stimulation devices 194. The liquid wire comprises a kind of metal that is enclosed in a flexible tube and remains in a liquid phase at room temperature. Thanks to the nature of its liquid phase, the liquid metal can make good contact with objects of any shape and can maintain excellent electrical properties when the substrate or the coated film is deformed. Non-limiting examples of liquid metals include alloys such as gallium and gallium-indium eutectic. The liquid wire circuit assembly 150 includes a connection terminal 160 to which an electronic circuit connector 162 is attached, and the electronic circuit connector 162 is configured to provide electrical communication between one or more liquid wire tubes of the circuit assembly 150 and the connection terminal 160. In these embodiments, the liquid wire circuit assembly 150 is configured to provide flexibility and comfort to the wearer. For example, since the headband 22 for photobiomodulation therapy must closely conform to the contour of the forehead, the liquid wire circuit assembly 150 is designed to have strategic cutouts to allow for maximum flexibility and comfort.

[0029] In some embodiments, referring to FIGS. 16 and 17, the liquid wire circuit assembly 150 includes a main liquid wire tube 152 that branches into three at its root 153 into a first liquid wire tube 154 that extends from a connection terminal 160 and is directly attached to the inner surface of the outer cloth sheet 40, a second liquid wire tube 156, and a sensor liquid wire tube 158 that extends from the center. The first liquid wire tube 154 and the second liquid wire tube 156 include the electronic circuits necessary to establish an electrical connection between each near-infrared light source 170 operably attached to the first liquid wire tube 154 or the second liquid wire tube 156 and the connection terminal 160 that provides an electrical connection to the controller 200 as a result. The sensor liquid wire tube 158 includes the electronic circuits necessary to establish electrical communication between each sensor 180 and / or each stimulation device 194 operably attached to the sensor liquid wire tube 158 and the connection terminal 160 that provides an electrical connection to the controller 200 as a result. By directly attaching the first liquid wire tube 154, the second liquid wire tube 156, and the sensor liquid wire tube 158 to the inner surface of the outer cloth sheet 40, the liquid wire circuit assembly 150 can be easily adapted to the contour of one or more regions of interest of the skin region S, and each of the one or more near-infrared light sources disclosed herein is arranged in close proximity to the skin surface S with a minimum gap or without a gap. Although not shown, the liquid wire circuit assembly 150 can be configured in an arrangement similar to the arrangement shown for the flexible printed circuit board assembly 110 of FIGS. 13-15.

[0030] Referring to FIGS. 10, 12-17, 21, and 25, the photobiomodulation unit 100 also includes one or more near-infrared light sources 170 each configured to emit near-infrared light in a wavelength range of 700 nm to 1600 nm. In some embodiments, the near-infrared light source 170 emits light having a wavelength of, for example, about 700 nm, about 750 nm, about 800 nm, about 900 nm, about 1000 nm, about 1100 nm, about 1200 nm, about 1,300 nm, about 1400 nm, or about 1500 nm. In some embodiments, the near-infrared light source 170 emits light having a wavelength of, for example, at least 700 nm, at least 750 nm, at least 800 nm, at least 850 nm, at least 900 nm, at least 1000 nm, at least 1100 nm, at least 1200 nm, at least 1,300 nm, at least 1400 nm, or at least 1500 nm. In some embodiments, the near-infrared light source 170 emits light having a wavelength of, for example, up to 700 nm, up to 750 nm, up to 800 nm, up to 850 nm, up to 900 nm, up to 1000 nm, up to 1100 nm, up to 1200 nm, up to 1,300 nm, up to 1400 nm, or up to 1500 nm.

[0031] In some embodiments, the near-infrared light source 170 emits light having a wavelength of, for example, about 700 nm to about 750 nm, about 700 nm to about 800 nm, about 700 nm to about 900 nm, about 700 nm to about 1000 nm, about 700 nm to about 1100 nm, about 700 nm to about 1200 nm, about 700 nm to about 1300 nm, about 700 nm to about 1400 nm, about 700 nm to about 1500 nm, about 750 nm to about 800 nm, about 750 nm to about 850 nm, about 750 nm to about 900 nm, about 750 nm to about 1000 nm, about 750 nm to about 1100 nm, about 750 nm to about 1200 nm, about 750 nm to about 1300 nm, about 750 nm to about 1400 nm, about 750 nm to about 1500 nm, about 800 nm to about 850 nm, about 800 nm to about 900 nm, about 800 nm to about 1000 nm, about 800 nm to about 1100 nm, about 800 nm to about 1200 nm, about 800 nm to about 1300 nm, about 800 nm to about 1400 nm, about 800 nm to about 1500 nm, about 850 nm to about 900 nm, about 850 nm to about 1000 nm, about 850 nm to about 1100 nm, about 850 nm to about 1200 nm, about 850 nm to about 1300 nm, about 850 nm to about 1400 nm, about 850 nm to about 1500 nm, about 900 nm to about 1000 nm, about 900 nm to about 1100 nm, about 900 nm to about 1200 nm, about 900 nm to about 1300 nm, about 900 nm to about 1400 nm, about 900 nm to about 1500 nm, about 1000 nm to about 1100 nm, about 1000 nm to about 1200 nm, about 1000 nm to about 1300 nm, about 1000 nm to about 1400 nm, about 1000 nm to about 1500 nm, about 1100 nm to about 1200 nm, about 1100 nm to about 1300 nm, about 1100 nm to about 1400 nm, about 1100 nm to about 1500 nm, about 1200 nm to about 1300 nm, about 1200 nm to about 1400 nm, about 1200 nm to about 1500 nm, about 1300 nm to about 1400 nm, about 1300 nm to about 1500 nm, or about 1400 nm to about 1500 nm.

[0032] In some embodiments, each of the one or more near-infrared light sources 170 is configured to emit near-infrared light in a pulse wave (or frequency) range of about 1 Hz to about 100 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave of, for example, about 10 Hz, about 20 Hz, about 30 Hz, about 40 Hz, about 50 Hz, about 60 Hz, about 70 Hz, about 80 Hz, about 90 Hz, or about 100 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave of, for example, at least 10 Hz, at least 20 Hz, at least 30 Hz, at least 40 Hz, at least 50 Hz, at least 60 Hz, at least 70 Hz, at least 80 Hz, at least 90 Hz, or at least 100 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave of, for example, at most 10 Hz, at most 20 Hz, at most 30 Hz, at most 40 Hz, at most 50 Hz, at most 60 Hz, at most 70 Hz, at most 80 Hz, at most 90 Hz, or at most 100 Hz.In some embodiments, the near-infrared light source 170 emits light having a pulse wave of, for example, about 10 Hz to about 20 Hz, about 10 Hz to about 30 Hz, about 10 Hz to about 40 Hz, about 10 Hz to about 50 Hz, about 10 Hz to about 60 Hz, about 10 Hz to about 70 Hz, about 10 Hz to about 80 Hz, about 10 Hz to about 90 Hz, about 10 Hz to about 100 Hz, about 20 Hz to about 30 Hz, about 20 Hz to about 40 Hz, about 20 Hz to about 50 Hz, about 20 Hz to about 60 Hz, about 20 Hz to about 70 Hz, about 20 Hz to about 80 Hz, about 20 Hz to about 90 Hz, about 20 Hz to about 100 Hz, about 30 Hz to about 40 Hz, about 30 Hz to about 50 Hz, about 30 Hz to about 60 Hz, about 30 Hz to about 70 Hz, about 30 Hz to about 80 Hz, about 30 Hz to about 90 Hz, about 30 Hz to about 100 Hz, about 40 Hz to about 50 Hz, about 40 Hz to about 60 Hz, about 40 Hz to about 70 Hz, about 40 Hz to about 80 Hz, about 40 Hz to about 90 Hz, about 40 Hz to about 100 Hz, about 50 Hz to about 60 Hz, about 50 Hz to about 70 Hz, about 50 Hz to about 80 Hz, about 50 Hz to about 90 Hz, about 50 Hz to about 100 Hz, about 60 Hz to about 70 Hz, about 60 Hz to about 80 Hz, about 60 Hz to about 90 Hz, about 60 Hz to about 100 Hz, about 70 Hz to about 80 Hz, about 70 Hz to about 90 Hz, about 70 Hz to about 100 Hz, about 80 Hz to about 90 Hz, about 80 Hz to about 100 Hz, or about 90 Hz to about 100 Hz.

[0033] In some embodiments, each of the one or more near-infrared light sources 170 is configured to emit near-infrared light in a pulse wave (or frequency) range of from about 100 Hz to about 1000 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave, for example, of about 100 Hz, about 200 Hz, about 300 Hz, about 400 Hz, about 500 Hz, about 600 Hz, about 700 Hz, about 800 Hz, about 900 Hz, or about 1000 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave of at least 100 Hz, at least 200 Hz, at least 300 Hz, at least 400 Hz, at least 500 Hz, at least 600 Hz, at least 700 Hz, at least 800 Hz, at least 900 Hz, or at least 1000 Hz, for example. In some embodiments, the near-infrared light source 170 emits light having a pulse wave of at most 100 Hz, at most 200 Hz, at most 300 Hz, at most 400 Hz, at most 500 Hz, at most 600 Hz, at most 700 Hz, at most 800 Hz, at most 900 Hz, or at most 1000 Hz, for example.In some embodiments, the near-infrared light source 170 emits light having a pulse wave of, for example, about 100 Hz to about 200 Hz, about 100 Hz to about 300 Hz, about 100 Hz to about 400 Hz, about 100 Hz to about 500 Hz, about 100 Hz to about 600 Hz, about 100 Hz to about 700 Hz, about 100 Hz to about 800 Hz, about 100 Hz to about 900 Hz, about 100 Hz to about 1000 Hz, about 200 Hz to about 300 Hz, about 200 Hz to about 400 Hz, about 200 Hz to about 500 Hz, about 200 Hz to about 600 Hz, about 200 Hz to about 700 Hz, about 200 Hz to about 800 Hz, about 200 Hz to about 900 Hz, about 200 Hz to about 1000 Hz, about 300 Hz to about 400 Hz, about 300 Hz to about 500 Hz, about 300 Hz to about 600 Hz, about 300 Hz to about 700 Hz, about 300 Hz to about 800 Hz, about 300 Hz to about 900 Hz, about 300 Hz to about 1000 Hz, about 400 Hz to about 500 Hz, about 400 Hz to about 600 Hz, about 400 Hz to about 700 Hz, about 400 Hz to about 800 Hz, about 400 Hz to about 900 Hz, about 400 Hz to about 1000 Hz, about 500 Hz to about 600 Hz, about 500 Hz to about 700 Hz, about 500 Hz to about 800 Hz, about 500 Hz to about 900 Hz, about 500 Hz to about 1000 Hz, about 600 Hz to about 700 Hz, about 600 Hz to about 800 Hz, about 600 Hz to about 900 Hz, about 600 Hz to about 1000 Hz, about 700 Hz to about 800 Hz, about 700 Hz to about 900 Hz, about 700 Hz to about 1000 Hz, about 800 Hz to about 900 Hz, about 800 Hz to about 1000 Hz, or about 900 Hz to about 1000 Hz.

[0034] In some embodiments, each of the one or more near-infrared light sources 170 is configured to emit near-infrared light in a pulse wave (or frequency) range of from about 1000 Hz to about 5000 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave, for example, of about 1000 Hz, about 2000 Hz, about 3000 Hz, about 4000 Hz, or about 5000 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave, for example, of at least 1000 Hz, at least 2000 Hz, at least 3000 Hz, at least 4000 Hz, or at least 5000 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave, for example, of at most 1000 Hz, at most 2000 Hz, at most 3000 Hz, at most 4000 Hz, or at most 5000 Hz. In some embodiments, the near-infrared light source 170 emits light having a pulse wave, for example, in a range of from about 1000 Hz to about 2000 Hz, from about 1000 Hz to about 3000 Hz, from about 1000 Hz to about 4000 Hz, from about 1000 Hz to about 5000 Hz, from about 2000 Hz to about 3000 Hz, from about 2000 Hz to about 4000 Hz, from about 2000 Hz to about 5000 Hz, from about 3000 Hz to about 4000 Hz, from about 3000 Hz to about 5000 Hz, or from about 4000 Hz to about 5000 Hz.

[0035] In some embodiments, each of the one or more near-infrared light sources 170 is configured to emit near-infrared light in a radiation energy range of from about 100 J to about 1100 J. In some embodiments, the near-infrared light source 170 has a radiation energy of, for example, about 100 J, about 200 J, about 300 J, about 400 J, about 500 J, about 600 J, about 700 J, about 800 J, about 900 J, about 1000 J, or about 1100 J. In some embodiments, the near-infrared light source 170 has a radiation energy of, for example, at least 100 J, at least 200 J, at least 300 J, at least 400 J, at least 500 J, at least 600 J, at least 700 J, at least 800 J, at least 900 J, at least 1000 J, or at least 1100 J. In some embodiments, the near-infrared light source 170 has a radiation energy of, for example, at most 100 J, at most 200 J, at most 300 J, at most 400 J, at most 500 J, at most 600 J, at most 700 J, at most 800 J, at most 900 J, at most 1000 J, or at most 1100 J.In some embodiments, the near-infrared light source 170 has radiant energy of, for example, about 100 J to about 200 J, about 100 J to about 300 J, about 100 J to about 400 J, about 100 J to about 500 J, about 100 J to about 600 J, about 100 J to about 700 J, about 100 J to about 800 J, about 100 J to about 900 J, about 100 J to about 1000 J, about 100 J to about 1100 J, about 200 J to about 300 J, about 200 J to about 400 J, about 200 J to about 500 J, about 200 J to about 600 J, about 200 J to about 700 J, about 200 J to about 800 J, about 200 J to about 900 J, about 200 J to about 1000 J, about 200 J to about 1100 J, about 300 J to about 400 J, about 300 J to about 500 J, about 300 J to about 600 J, about 300 J to about 700 J, about 300 J to about 800 J, about 300 J to about 900 J, about 300 J to about 1000 J, about 300 J to about 1100 J, about 400 J to about 500 J, about 400 J to about 600 J, about 400 J to about 700 J, about 400 J to about 800 J, about 400 J to about 900 J, about 400 J to about 1000 J, about 400 J to about 1100 J, about 500 J to about 600 J, about 500 J to about 700 J, about 500 J to about 800 J, about 500 J to about 900 J, about 500 J to about 1000 J, about 500 J to about 1100 J, about 600 J to about 700 J, about 600 J to about 800 J, about 600 J to about 900 J, about 600 J to about 1000 J, about 600 J to about 1100 J, about 700 J to about 800 J, about 700 J to about 900 J, about 700 J to about 1000 J, about 700 J to about 1100 J, about 800 J to about 900 J, about 800 J to about 1000 J, about 800 J to about 1100 J, about 900 J to about 1000 J, about 900 J to about 1100 J, or about 1000 J to about 1100 J.

[0036] In some embodiments, each of the one or more near-infrared light sources 170 is configured to emit near-infrared light in a radiation energy range of from about 500 J to about 7,000 J. In some embodiments, the near-infrared light source 170 has a radiation energy of, for example, about 500 J, about 750 J, about 1,000 J, about 1,500 J, about 2,000 J, about 2,500 J, about 3,000 J, about 3,500 J, about 4,000 J, about 4,500 J, about 5,000 J, about 5,500 J, about 6,000 J, about 6,500 J, or about 7,000 J. In some embodiments, the near-infrared light source 170 has a radiation energy of, for example, at least 500 J, at least 750 J, at least 1,000 J, at least 1,500 J, at least 2,000 J, at least 2,500 J, at least 3,000 J, at least 3,500 J, at least 4,000 J, at least 4,500 J, at least 5,000 J, at least 5,500 J, at least 6,000 J, at least 6,500 J, at least 7,000 J. In some embodiments, the near-infrared light source 170 has a radiation energy of, for example, up to 500 J, up to 750 J, up to 1,000 J, up to 1,500 J, up to 2,000 J, up to 2,500 J, up to 3,000 J, up to 3,500 J, up to 4,000 J, up to 4,500 J, up to 5,000 J, up to 5,500 J, up to 6,000 J, up to 6,500 J, up to 7,000 J.In some embodiments, the near-infrared light source 170 has a radiant energy of, for example, about 500 J to about 1,000 J, about 500 J to about 1,500 J, about 500 J to about 2,000 J, about 500 J to about 2,500 J, about 500 J to about 3,000 J, about 500 J to about 3,500 J, about 500 J to about 4,000 J, about 500 J to about 4,500 J, about 500 J to about 5,000 J, about 500 J to about 5,500 J, about 500 J to about 6,000 J, about 500 J to about 6,500 J, about 500 J to about 7,000 J, about 750 J to about 1,000 J, about 750 J to about 1,500 J, about 750 J to about 2,000 J, about 750 J to about 2,500 J, about 750 J to about 3,000 J, about 750 J to about 3,500 J, about 750 J to about 4,000 J, about 750 J to about 4,500 J, about 750 J to about 5,000 J, about 750 J to about 5,500 J, about 750 J to about 6,000 J, about 750 J to about 6,500 J, about 750 J to about 7,000 J, about 1,000 J to about 1,500 J, about 1,000 J to about 2,000 J, about 1,000 J to about 2,500 J, about 1,000 J to about 3,000 J, about 1,000 J to about 3,500 J, about 1,000 J to about 4,000 J, about 1,000 J to about 4,500 J, about 1,000 J to about 5,000 J, about 1,000 J to about 5,500 J, about 1,000 J to about 6,000 J, about 1,000 J to about 6,500 J, or about 1,000 J to about 7,000 J.

[0037] In some embodiments, one or more of the near-infrared light sources 170 are each configured to emit near-infrared light in a radiant exposure (fluence rate) range of about 5 mW / cm 2 to about 100 mW / cm 2 . In some embodiments, the near-infrared light source 170 is, for example, about 5 mW / cm 2 , about 10 mW / cm 2 , about 15 mW / cm 2 , about 20 mW / cm 2 , about 25 mW / cm 2 , about 30 mW / cm 2 , about 35 mW / cm 2 , about 40 mW / cm 2 , about 50 mW / cm 2 , about 60 mW / cm 2 , about 70 mW / cm 2, about 80 mW / cm 2 , about 90 mW / cm 2 , or about 100 mW / cm 2 has an irradiance (beam density). In some embodiments, the near-infrared light source 170 is, for example, at least 5 mW / cm 2 , at least 10 mW / cm 2 , at least 15 mW / cm 2 , at least 20 mW / cm 2 , at least 25 mW / cm 2 , at least 30 mW / cm 2 , at least 35 mW / cm 2 , at least 40 mW / cm 2 , at least 50 mW / cm 2 , at least 60 mW / cm 2 , at least 70 mW / cm 2 , at least 80 mW / cm 2 , at least 90 mW / cm 2 , or at least 100 mW / cm 2 has an irradiance (beam density). In some embodiments, the near-infrared light source 170 is, for example, at most 5 mW / cm 2 , at most 10 mW / cm 2 , at most 15 mW / cm 2 , at most 20 mW / cm 2 , at most 25 mW / cm 2 , at most 30 mW / cm 2 , at most 35 mW / cm 2 , at most 40 mW / cm 2 , at most 50 mW / cm 2 , at most 60 mW / cm 2 , at most 70 mW / cm 2 , at most 80 mW / cm 2 , at most 90 mW / cm 2 , or at most 100 mW / cm 2 has an irradiance (beam density). In some embodiments, the near-infrared light source 170 is, for example, about 5 mW / cm 2 to about 10 mW / cm 2 , about 5 mW / cm 2 to about 15 mW / cm 2 , about 5 mW / cm 2~about 20 mW / cm 2 、about 5 mW / cm 2 ~about 25 mW / cm 2 、about 5 mW / cm 2 ~about 30 mW / cm 2 、about 5 mW / cm 2 ~about 35 mW / cm 2 、about 10 mW / cm 2 ~about 15 mW / cm 2 、about 10 mW / cm 2 ~about 20 mW / cm 2 、about 10 mW / cm 2 ~about 25 mW / cm 2 、about 10 mW / cm 2 ~about 30 mW / cm 2 、about 10 mW / cm 2 ~about 35 mW / cm 2 、about 15 mW / cm 2 ~about 20 mW / cm 2 、about 15 mW / cm 2 ~about 25 mW / cm 2 、about 15 mW / cm 2 ~about 30 mW / cm 2 、about 15 mW / cm 2 ~about 35 mW / cm 2 、about 20 mW / cm 2 ~about 25 mW / cm 2 、about 20 mW / cm 2 ~about 30 mW / cm 2 、about 20 mW / cm 2 ~about 35 mW / cm 2 、about 25 mW / cm 2 ~about 30 mW / cm 2 、about 25 mW / cm 2 ~about 35 mW / cm 2 、or about 30 mW / cm 2 ~about 35 mW / cm 2 having an irradiance (beam density) of. In some embodiments, the near-infrared light source 170 is, for example, about 20 mW / cm 2 ~about 50 mW / cm 2 、about 20 mW / cm 2 ~about 60 mW / cm 2 、about 20 mW / cm 2 ~about 70 mW / cm 2 、about 20 mW / cm2 ~ about 80 mW / cm 2 、 about 20 mW / cm 2 ~ about 90 mW / cm 2 、 about 20 mW / cm 2 ~ about 100 mW / cm 2 、 about 30 mW / cm 2 ~ about 60 mW / cm 2 、 about 30 mW / cm 2 ~ about 70 mW / cm 2 、 about 30 mW / cm 2 ~ about 80 mW / cm 2 、 about 30 mW / cm 2 ~ about 90 mW / cm 2 、 about 30 mW / cm 2 ~ about 100 mW / cm 2 、 about 40 mW / cm 2 ~ about 60 mW / cm 2 、 about 40 mW / cm 2 ~ about 70 mW / cm 2 、 about 40 mW / cm 2 ~ about 80 mW / cm 2 、 about 40 mW / cm 2 ~ about 90 mW / cm 2 、 about 40 mW / cm 2 ~ about 100 mW / cm 2 、 about 50 mW / cm 2 ~ about 60 mW / cm 2 、 about 50 mW / cm 2 ~ about 70 mW / cm 2 、 about 50 mW / cm 2 ~ about 80 mW / cm 2 、 about 50 mW / cm 2 ~ about 90 mW / cm 2 、 about 50 mW / cm 2 ~ about 100 mW / cm 2 、 about 60 mW / cm 2 ~ about 70 mW / cm 2 、 about 60 mW / cm 2 ~ about 80 mW / cm 2 、 about 60 mW / cm 2 ~ about 90 mW / cm 2 、 about 60 mW / cm 2 ~ about 100 mW / cm 2 、 about 70 mW / cm 2 ~ about 80 mW / cm2 , about 70 mW / cm 2 ~ about 90 mW / cm 2 , about 70 mW / cm 2 ~ about 100 mW / cm 2 , about 80 mW / cm 2 ~ about 90 mW / cm 2 , about 80 mW / cm 2 ~ about 100 mW / cm 2 , or about 90 mW / cm 2 ~ about 100 mW / cm 2 and has an irradiance (beam density) of

[0038] In some embodiments, each of the one or more near-infrared light sources 170 is configured to emit near-infrared light in an irradiance (beam density) range of about 100 mW / cm 2 ~ about 1000 mW / cm 2 . In some embodiments, the near-infrared light source 170 is, for example, about 50 mW / cm 2 , about 100 mW / cm 2 , about 150 mW / cm 2 , about 200 mW / cm 2 , about 250 mW / cm 2 , about 300 mW / cm 2 , about 350 mW / cm 2 , about 400 mW / cm 2 , about 450 mW / cm 2 , about 500 mW / cm 2 , about 600 mW / cm 2 , about 700 mW / cm 2 , about 800 mW / cm 2 , about 900 mW / cm 2 , or about 1000 mW / cm 2 and has an irradiance (beam density). In some embodiments, the near-infrared light source 170 is, for example, at least 50 mW / cm 2 , at least 100 mW / cm 2 , at least 150 mW / cm 2 , at least 200 mW / cm 2 , at least 250 mW / cm 2 , at least 300 mW / cm 2 , at least 350 mW / cm 2, at least 400 mW / cm 2 , at least 450 mW / cm 2 , at least 500 mW / cm 2 , at least 600 mW / cm 2 , at least 700 mW / cm 2 , at least 800 mW / cm 2 , at least 900 mW / cm 2 , or at least 1000 mW / cm 2 has an irradiance (beam density). In some embodiments, the near-infrared light source 170 is, for example, up to 50 mW / cm 2 , up to 100 mW / cm 2 , up to 150 mW / cm 2 , up to 200 mW / cm 2 , up to 250 mW / cm 2 , up to 300 mW / cm 2 , up to 350 mW / cm 2 , up to 400 mW / cm 2 , up to 450 mW / cm 2 , up to 500 mW / cm 2 , up to 600 mW / cm 2 , up to 700 mW / cm 2 , up to 800 mW / cm 2 , up to 900 mW / cm 2 , or up to 1000 mW / cm 2 has an irradiance (beam density). In some embodiments, the near-infrared light source 170 is, for example, about 50 mW / cm 2 to about 100 mW / cm 2 , about 50 mW / cm 2 to about 150 mW / cm 2 , about 50 mW / cm 2 to about 200 mW / cm 2 , about 50 mW / cm 2 to about 250 mW / cm 2 , about 50 mW / cm 2 to about 300 mW / cm 2 , about 50 mW / cm 2 to about 350 mW / cm 2 , about 50 mW / cm 2 to about 400 mW / cm 2 , about 50 mW / cm2 ~ about 450 mW / cm 2 、 about 50 mW / cm 2 ~ about 500 mW / cm 2 、 about 50 mW / cm 2 ~ about 600 mW / cm 2 、 about 50 mW / cm 2 ~ about 700 mW / cm 2 、 about 50 mW / cm 2 ~ about 800 mW / cm 2 、 about 50 mW / cm 2 ~ about 900 mW / cm 2 、 about 50 mW / cm 2 ~ about 1000 mW / cm 2 、 about 100 mW / cm 2 ~ about 200 mW / cm 2 、 about 100 mW / cm 2 ~ about 250 mW / cm 2 、 about 100 mW / cm 2 ~ about 300 mW / cm 2 、 about 100 mW / cm 2 ~ about 350 mW / cm 2 、 about 100 mW / cm 2 ~ about 400 mW / cm 2 、 about 100 mW / cm 2 ~ about 450 mW / cm 2 、 about 100 mW / cm 2 ~ about 500 mW / cm 2 、 about 100 mW / cm 2 ~ about 600 mW / cm 2 、 about 100 mW / cm 2 ~ about 700 mW / cm 2 、 about 100 mW / cm 2 ~ about 800 mW / cm 2 、 about 100 mW / cm 2 ~ about 900 mW / cm 2 、 about 100 mW / cm 2 ~ about 1000 mW / cm 2 、 about 150 mW / cm 2 ~ about 200 mW / cm 2 、 about 150 mW / cm 2 ~ about 250 mW / cm 2 、 about 150 mW / cm 2 ~ about 300 mW / cm 2, about 150 mW / cm 2 ~ about 350 mW / cm 2 , about 150 mW / cm 2 ~ about 400 mW / cm 2 , about 150 mW / cm 2 ~ about 450 mW / cm 2 , about 150 mW / cm 2 ~ about 500 mW / cm 2 , about 150 mW / cm 2 ~ about 600 mW / cm 2 , about 150 mW / cm 2 ~ about 700 mW / cm 2 , about 150 mW / cm 2 ~ about 800 mW / cm 2 , about 150 mW / cm 2 ~ about 900 mW / cm 2 , about 150 mW / cm 2 ~ about 1000 mW / cm 2 , about 200 mW / cm 2 ~ about 300 mW / cm 2 , about 200 mW / cm 2 ~ about 350 mW / cm 2 , about 200 mW / cm 2 ~ about 400 mW / cm 2 , about 200 mW / cm 2 ~ about 450 mW / cm 2 , about 200 mW / cm 2 ~ about 500 mW / cm 2 , about 200 mW / cm 2 ~ about 600 mW / cm 2 , about 200 mW / cm 2 ~ about 700 mW / cm 2 , about 200 mW / cm 2 ~ about 800 mW / cm 2 , about 200 mW / cm 2 ~ about 900 mW / cm 2 , about 200 mW / cm 2 ~ about 1000 mW / cm 2 , about 300 mW / cm 2 ~ about 400 mW / cm 2 , about 300 mW / cm 2 ~ about 500 mW / cm 2 , about 300 mW / cm 2 ~ about 600 mW / cm2 , about 300 mW / cm 2 ~ about 700 mW / cm 2 , about 300 mW / cm 2 ~ about 800 mW / cm 2 , about 300 mW / cm 2 ~ about 900 mW / cm 2 , about 300 mW / cm 2 ~ about 1000 mW / cm 2 , about 400 mW / cm 2 ~ about 500 mW / cm 2 , about 400 mW / cm 2 ~ about 600 mW / cm 2 , about 400 mW / cm 2 ~ about 700 mW / cm 2 , about 400 mW / cm 2 ~ about 800 mW / cm 2 , about 400 mW / cm 2 ~ about 900 mW / cm 2 , about 400 mW / cm 2 ~ about 1000 mW / cm 2 , about 500 mW / cm 2 ~ about 600 mW / cm 2 , about 500 mW / cm 2 ~ about 700 mW / cm 2 , about 500 mW / cm 2 ~ about 800 mW / cm 2 , about 500 mW / cm 2 ~ about 900 mW / cm 2 , about 500 mW / cm 2 ~ about 1000 mW / cm 2 , about 600 mW / cm 2 ~ about 700 mW / cm 2 , about 600 mW / cm 2 ~ about 800 mW / cm 2 , about 600 mW / cm 2 ~ about 900 mW / cm 2 , about 600 mW / cm 2 ~ about 1000 mW / cm 2 , about 700 mW / cm 2 ~ about 800 mW / cm 2 , about 700 mW / cm 2 ~ about 900 mW / cm 2 , about 700 mW / cm2 ~ about 1000 mW / cm 2 、 about 800 mW / cm 2 ~ about 900 mW / cm 2 、 about 800 mW / cm 2 ~ about 1000 mW / cm 2 、 or about 900 mW / cm 2 ~ about 1000 mW / cm 2 and has an irradiance (beam density) of.

[0039] In some embodiments, each of the one or more near-infrared light sources 170 is configured to emit near-infrared light in a range of radiant exposure (fluence) of about 5 J / cm 2 ~ about 200 J / cm 2 Some embodiments, the near-infrared light source 170 is, for example, about 5 J / cm 2 、 about 10 J / cm 2 、 about 15 J / cm 2 、 about 20 J / cm 2 、 about 30 J / cm 2 、 about 40 J / cm 2 、 about 50 J / cm 2 、 about 60 J / cm 2 、 about 65 J / cm 2 、 about 70 J / cm 2 、 about 75 J / cm 2 、 about 80 J / cm 2 、 about 85 J / cm 2 、 about 90 J / cm 2 、 about 100 J / cm 2 、 about 110 J / cm 2 、 about 120 J / cm 2 、 about 130 J / cm 2 、 about 140 J / cm 2 、 about 150 J / cm 2 、 about 160 J / cm 2 、 about 170 J / cm 2 、 about 175 J / cm 2 、 about 180 J / cm 2 、 about 190 J / cm 2 、 or about 200 J / cm 2 and has a radiant exposure (fluence). In some embodiments, the near-infrared light source 170 is, for example, at least 5 J / cm 2 、 at least 10 J / cm2 、at least 15 J / cm 2 、at least 20 J / cm 2 、at least 30 J / cm 2 、at least 40 J / cm 2 、at least 50 J / cm 2 、at least 60 J / cm 2 、at least 65 J / cm 2 、at least 70 J / cm 2 、at least 75 J / cm 2 、at least 80 J / cm 2 、at least 85 J / cm 2 、at least 90 J / cm 2 、at least 100 J / cm 2 、at least 110 J / cm 2 、at least 120 J / cm 2 、at least 130 J / cm 2 、at least 140 J / cm 2 、at least 150 J / cm 2 、at least 160 J / cm 2 、at least 170 J / cm 2 、at least 175 J / cm 2 、at least 180 J / cm 2 、at least 190 J / cm 2 、or at least 200 J / cm 2 and has a radiant exposure (fluence) of. In some embodiments, the near-infrared light source 170 is, for example, at most 5 J / cm 2 、at most 10 J / cm 2 、at most 15 J / cm 2 、at most 20 J / cm 2 、at most 30 J / cm 2 、at most 40 J / cm 2 、at most 50 J / cm 2 、at most 60 J / cm 2 、at most 65 J / cm 2 、at most 70 J / cm 2 、at most 75 J / cm 2 、at most 80 J / cm 2 、at most 85 J / cm 2 、at most 90 J / cm 2 、at most 100 J / cm2 , up to 110 J / cm 2 , up to 120 J / cm 2 , up to 130 J / cm 2 , up to 140 J / cm 2 , up to 150 J / cm 2 , up to 160 J / cm 2 , up to 170 J / cm 2 , up to 175 J / cm 2 , up to 180 J / cm 2 , up to 190 J / cm 2 , or up to 200 J / cm 2 has a radiant exposure (fluence) of. In some embodiments, the near-infrared light source 170 is, for example, about 5 J / cm 2 ~ about 10 J / cm 2 , about 5 J / cm 2 ~ about 15 J / cm 2 , about 5 J / cm 2 ~ about 20 J / cm 2 , about 5 J / cm 2 ~ about 30 J / cm 2 , about 5 J / cm 2 ~ about 40 J / cm 2 , about 5 J / cm 2 ~ about 50 J / cm 2 , about 5 J / cm 2 ~ about 60 J / cm 2 , about 5 J / cm 2 ~ about 70 J / cm 2 , about 5 J / cm 2 ~ about 75 J / cm 2 , about 5 J / cm 2 ~ about 80 J / cm 2 , about 5 J / cm 2 ~ about 90 J / cm 2 , about 5 J / cm 2 ~ about 100 J / cm 2 , about 10 J / cm 2 ~ about 15 J / cm 2 , about 10 J / cm 2 ~ about 20 J / cm 2 , about 10 J / cm 2 ~ about 30 J / cm 2 , about 10 J / cm 2 ~ about 40 J / cm 2 , about 10 J / cm 2~about 50 J / cm 2 、about 10 J / cm 2 ~about 60 J / cm 2 、about 10 J / cm 2 ~about 70 J / cm 2 、about 10 J / cm 2 ~about 75 J / cm 2 、about 10 J / cm 2 ~about 80 J / cm 2 、about 10 J / cm 2 ~about 90 J / cm 2 、about 10 J / cm 2 ~about 100 J / cm 2 、about 20 J / cm 2 ~about 30 J / cm 2 、about 20 J / cm 2 ~about 40 J / cm 2 、about 20 J / cm 2 ~about 50 J / cm 2 、about 20 J / cm 2 ~about 60 J / cm 2 、about 20 J / cm 2 ~about 70 J / cm 2 、about 20 J / cm 2 ~about 75 J / cm 2 、about 20 J / cm 2 ~about 80 J / cm 2 、about 20 J / cm 2 ~about 90 J / cm 2 、about 20 J / cm 2 ~about 100 J / cm 2 、about 20 J / cm 2 ~about 110 J / cm 2 、about 20 J / cm 2 ~about 120 J / cm 2 、about 20 J / cm 2 ~about 130 J / cm 2 、about 20 J / cm 2 ~about 140 J / cm 2 、about 20 J / cm 2 ~about 150 J / cm 2 、about 20 J / cm 2 ~about 160 J / cm 2 、about 20 J / cm 2 ~about 170 J / cm 2 、about 20 J / cm 2 ~about 180 J / cm 2, about 20 J / cm 2 ~ about 190 J / cm 2 , about 20 J / cm 2 ~ about 200 J / cm 2 , about 30 J / cm 2 ~ about 40 J / cm 2 , about 30 J / cm 2 ~ about 50 J / cm 2 , about 30 J / cm 2 ~ about 60 J / cm 2 , about 30 J / cm 2 ~ about 70 J / cm 2 , about 30 J / cm 2 ~ about 75 J / cm 2 , about 30 J / cm 2 ~ about 80 J / cm 2 , about 30 J / cm 2 ~ about 90 J / cm 2 , about 30 J / cm 2 ~ about 100 J / cm 2 , about 30 J / cm 2 ~ about 110 J / cm 2 , about 30 J / cm 2 ~ about 120 J / cm 2 , about 30 J / cm 2 ~ about 130 J / cm 2 , about 30 J / cm 2 ~ about 140 J / cm 2 , about 30 J / cm 2 ~ about 150 J / cm 2 , about 30 J / cm 2 ~ about 160 J / cm 2 , about 30 J / cm 2 ~ about 170 J / cm 2 , about 30 J / cm 2 ~ about 180 J / cm 2 , about 30 J / cm 2 ~ about 190 J / cm 2 , about 30 J / cm 2 ~ about 200 J / cm 2 , about 40 J / cm 2 ~ about 50 J / cm 2 , about 40 J / cm 2 ~ about 60 J / cm 2 , about 40 J / cm 2 ~ about 70 J / cm 2 , about 40 J / cm 2~ about 75 J / cm 2 、 about 40 J / cm 2 ~ about 80 J / cm 2 、 about 40 J / cm 2 ~ about 90 J / cm 2 、 about 40 J / cm 2 ~ about 100 J / cm 2 、 about 40 J / cm 2 ~ about 110 J / cm 2 、 about 40 J / cm 2 ~ about 120 J / cm 2 、 about 40 J / cm 2 ~ about 130 J / cm 2 、 about 40 J / cm 2 ~ about 140 J / cm 2 、 about 40 J / cm 2 ~ about 150 J / cm 2 、 about 40 J / cm 2 ~ about 160 J / cm 2 、 about 40 J / cm 2 ~ about 170 J / cm 2 、 about 40 J / cm 2 ~ about 180 J / cm 2 、 about 40 J / cm 2 ~ about 190 J / cm 2 、 about 40 J / cm 2 ~ about 200 J / cm 2 、 about 50 J / cm 2 ~ about 60 J / cm 2 、 about 50 J / cm 2 ~ about 70 J / cm 2 、 about 50 J / cm 2 ~ about 75 J / cm 2 、 about 50 J / cm 2 ~ about 80 J / cm 2 、 about 50 J / cm 2 ~ about 90 J / cm 2 、 about 50 J / cm 2 ~ about 100 J / cm 2 、 about 50 J / cm 2 ~ about 110 J / cm 2 、 about 50 J / cm 2 ~ about 120 J / cm 2 、 about 50 J / cm 2 ~ about 130 J / cm 2 、 about 50 J / cm 2 ~ about 140 J / cm 2, about 50 J / cm 2 ~ about 150 J / cm 2 , about 50 J / cm 2 ~ about 160 J / cm 2 , about 50 J / cm 2 ~ about 170 J / cm 2 , about 50 J / cm 2 ~ about 180 J / cm 2 , about 50 J / cm 2 ~ about 190 J / cm 2 , about 50 J / cm 2 ~ about 200 J / cm 2 , about 60 J / cm 2 ~ about 70 J / cm 2 , about 60 J / cm 2 ~ about 80 J / cm 2 , about 60 J / cm 2 ~ about 90 J / cm 2 , about 60 J / cm 2 ~ about 100 J / cm 2 , about 60 J / cm 2 ~ about 110 J / cm 2 , about 60 J / cm 2 ~ about 120 J / cm 2 , about 60 J / cm 2 ~ about 130 J / cm 2 , about 60 J / cm 2 ~ about 140 J / cm 2 , about 60 J / cm 2 ~ about 150 J / cm 2 , about 60 J / cm 2 ~ about 160 J / cm 2 , about 60 J / cm 2 ~ about 170 J / cm 2 , about 60 J / cm 2 ~ about 180 J / cm 2 , about 60 J / cm 2 ~ about 190 J / cm 2 , about 60 J / cm 2 ~ about 200 J / cm 2 , about 70 J / cm 2 ~ about 80 J / cm 2 , about 70 J / cm 2 ~ about 90 J / cm 2 , about 70 J / cm 2 ~ about 100 J / cm 2 , about 80 J / cm2 ~ about 90 J / cm 2 、about 80 J / cm 2 ~ about 100 J / cm 2 、or about 90 J / cm 2 ~ about 100 J / cm 2 has a radiant exposure (fluence).

[0040] In some embodiments, each of the one or more near-infrared light sources 170 is configured to emit near-infrared light in a radiant exposure (fluence) range of about 100 J / cm 2 ~ about 1000 J / cm 2 In some embodiments, the near-infrared light source 170 is, for example, about 100 J / cm 2 、about 200 J / cm 2 、about 300 J / cm 2 、about 400 J / cm 2 、about 500 J / cm 2 、about 600 J / cm 2 、about 700 J / cm 2 、about 800 J / cm 2 、about 900 J / cm 2 、or about 1000 J / cm 2 has a radiant exposure (fluence). In some embodiments, the near-infrared light source 170 is, for example, at least 100 J / cm 2 、at least 200 J / cm 2 、at least 300 J / cm 2 、at least 400 J / cm 2 、at least 500 J / cm 2 、at least 600 J / cm 2 、at least 700 J / cm 2 、at least 800 J / cm 2 、at least 900 J / cm 2 、or at least 1000 J / cm 2 has a radiant exposure (fluence). In some embodiments, the near-infrared light source 170 is, for example, up to 100 J / cm 2 、up to 200 J / cm 2 、up to 300 J / cm 2 、up to 400 J / cm 2 、up to 500 J / cm 2, up to 600 J / cm 2 , up to 700 J / cm 2 , up to 800 J / cm 2 , up to 900 J / cm 2 , or up to 1000 J / cm 2 of radiant exposure (fluence). In some embodiments, the near-infrared light source 170 is, for example, from about 100 J / cm 2 to about 200 J / cm 2 , from about 100 J / cm 2 to about 300 J / cm 2 , from about 100 J / cm 2 to about 400 J / cm 2 , from about 100 J / cm 2 to about 500 J / cm 2 , from about 100 J / cm 2 to about 600 J / cm 2 , from about 100 J / cm 2 to about 700 J / cm 2 , from about 100 J / cm 2 to about 800 J / cm 2 , from about 100 J / cm 2 to about 900 J / cm 2 , from about 100 J / cm 2 to about 1000 J / cm 2 , from about 200 J / cm 2 to about 300 J / cm 2 , from about 200 J / cm 2 to about 400 J / cm 2 , from about 200 J / cm 2 to about 500 J / cm 2 , from about 200 J / cm 2 to about 600 J / cm 2 , from about 200 J / cm 2 to about 700 J / cm 2 , from about 200 J / cm 2 to about 800 J / cm 2 , from about 200 J / cm 2 to about 900 J / cm 2 , from about 200 J / cm 2 to about 1000 J / cm 2 , from about 300 J / cm 2 to about 400 J / cm 2 , from about 300 J / cm 2 to about 500 J / cm 2, about 300 J / cm 2 ~ about 600 J / cm 2 , about 300 J / cm 2 ~ about 700 J / cm 2 , about 300 J / cm 2 ~ about 800 J / cm 2 , about 300 J / cm 2 ~ about 900 J / cm 2 , about 300 J / cm 2 ~ about 1000 J / cm 2 , about 400 J / cm 2 ~ about 500 J / cm 2 , about 400 J / cm 2 ~ about 600 J / cm 2 , about 400 J / cm 2 ~ about 700 J / cm 2 , about 400 J / cm 2 ~ about 800 J / cm 2 , about 400 J / cm 2 ~ about 900 J / cm 2 , about 400 J / cm 2 ~ about 1000 J / cm 2 , about 500 J / cm 2 ~ about 600 J / cm 2 , about 500 J / cm 2 ~ about 700 J / cm 2 , about 500 J / cm 2 ~ about 800 J / cm 2 , about 500 J / cm 2 ~ about 900 J / cm 2 , about 500 J / cm 2 ~ about 1000 J / cm 2 , about 600 J / cm 2 ~ about 700 J / cm 2 , about 600 J / cm 2 ~ about 800 J / cm 2 , about 600 J / cm 2 ~ about 900 J / cm 2 , about 600 J / cm 2 ~ about 1000 J / cm 2 , about 700 J / cm 2 ~ about 800 J / cm 2 , about 700 J / cm 2 ~ about 900 J / cm 2 , about 700 J / cm 2~ about 1000 J / cm 2 、 about 800 J / cm 2 ~ about 900 J / cm 2 、 about 800 J / cm 2 ~ about 1000 J / cm 2 、 or about 900 J / cm 2 ~ about 1000 J / cm 2 has radiant exposure (fluence) of

[0041] In some embodiments, the near-infrared light source 170 is a high-power infrared light source. In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, about 400 mW, about 425 mW, about 450 mW, about 500 mW, about 525 mW, about 550 mW, about 575 mW, or about 600 mW. In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, at least 400 mW, at least 425 mW, at least 450 mW, at least 500 mW, at least 525 mW, at least 550 mW, at least 575 mW, or at least 600 mW. In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, at most 400 mW, at most 425 mW, at most 450 mW, at most 500 mW, at most 525 mW, at most 550 mW, at most 575 mW, or at most 600 mW. In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, about 400 mW to about 450 mW, about 400 mW to about 500 mW, about 400 mW to about 550 mW, about 400 mW to about 600 mW, about 450 mW to about 500 mW, about 450 mW to about 550 mW, about 450 mW to about 600 mW, about 500 mW to about 550 mW, about 500 mW to about 600 mW, or about 550 mW to about 600 mW.

[0042] In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, about 100 mW, about 200 mW, about 300 mW, about 400 mW, about 500 mW, about 600 mW, about 700 mW, about 800 mW, about 900 mW, or about 1000 mW. In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, at least 100 mW, at least 200 mW, at least 300 mW, at least 400 mW, at least 500 mW, at least 600 mW, at least 700 mW, at least 800 mW, at least 900 mW, or at least 1000 mW. In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, up to 100 mW, up to 200 mW, up to 300 mW, up to 400 mW, up to 500 mW, up to 600 mW, up to 700 mW, up to 800 mW, up to 900 mW, or up to 1000 mW.In some embodiments, the high-power near-infrared light source has a radiation beam (output) of, for example, about 100 mW to about 200 mW, about 100 mW to about 300 mW, about 100 mW to about 400 mW, about 100 mW to about 500 mW, about 100 mW to about 600 mW, about 100 mW to about 700 mW, about 100 mW to about 800 mW, about 100 mW to about 900 mW, about 100 mW to about 1000 mW, about 200 mW to about 300 mW, about 200 mW to about 400 mW, about 200 mW to about 500 mW, about 200 mW to about 600 mW, about 200 mW to about 700 mW, about 200 mW to about 800 mW, about 200 mW to about 900 mW, about 200 mW to about 1000 mW, about 300 mW to about 400 mW, about 300 mW to about 500 mW, about 300 mW to about 600 mW, about 300 mW to about 700 mW, about 300 mW to about 800 mW, about 300 mW to about 900 mW, about 300 mW to about 1000 mW, about 400 mW to about 500 mW, about 400 mW to about 600 mW, about 400 mW to about 700 mW, about 400 mW to about 800 mW, about 400 mW to about 900 mW, about 400 mW to about 1000 mW, about 500 mW to about 600 mW, about 500 mW to about 700 mW, about 500 mW to about 800 mW, about 500 mW to about 900 mW, about 500 mW to about 1000 mW, about 600 mW to about 700 mW, about 600 mW to about 800 mW, about 600 mW to about 900 mW, about 600 mW to about 1000 mW, about 700 mW to about 800 mW, about 700 mW to about 900 mW, about 700 mW to about 1000 mW, about 800 mW to about 900 mW, about 800 mW to about 1000 mW, or about 900 mW to about 1000 mW.

[0043] In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, about 500 mW, about 750 mW, about 1,000 mW, about 1,250 mW, about 1,500 mW, about 1,750 mW, about 2,000 mW, about 2,250 mW, about 2,500 mW, about 2,750 mW, about 3,000 mW, about 3,250 mW, about 3,500 mW, about 3,750 mW, about 4,000 mW, about 4,250 mW, about 4,500 mW, about 4,750 mW, about 5,000 mW, about 5,250 mW, about 5,500 mW, about 5,750 mW, about 6,000 mW, about 6,250 mW, about 6,500 mW, about 6,750 mW, about 7,000 mW, about 7,250 mW, about 7,500 mW, about 7,750 mW, about 8,000 mW, about 8,250 mW, about 8,500 mW, about 8,750 mW, or about 9,000 mW. In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, at least 500 mW, at least 750 mW, at least 1,000 mW, at least 1,250 mW, at least 1,500 mW, at least 1,750 mW, at least 2,000 mW, at least 2,250 mW, at least 2,500 mW, at least 2,750 mW, at least 3,000 mW, at least 3,250 mW, at least 3,500 mW, at least 3,750 mW, at least 4,000 mW, at least 4,250 mW, at least 4,500 mW, at least 4,750 mW, at least 5,000 mW, at least 5,250 mW, at least 5,500 mW, at least 5,750 mW, at least 6,000 mW, at least 6,250 mW, at least 6,500 mW, at least 6,750 mW, at least 7,000 mW, at least 7,250 mW, at least 7,500 mW, at least 7,750 mW, at least 8,000 mW, at least 8,250 mW, at least 8,500 mW, at least 8,750 mW, or at least 9,000 mW. In some embodiments, the high-power near-infrared light source has a radiant flux (output) of, for example, up to 500 mW, up to 750 mW, up to 1,000 mW, up to 1,250 mW, up to 1,500 mW, up to 1,750 mW, up to 2,000 mW, up to 2,250 mW, up to 2,500 mW, up to 2,750 mW, up to 3,000 mW, up to 3,250 mW, up to 3,It has a radiation beam (output) of 500 mW, up to 3,750 mW, up to 4,000 mW, up to 4,250 mW, up to 4,500 mW, up to 4,750 mW, up to 5,000 mW, up to 5,250 mW, up to 5,500 mW, up to 5,750 mW, up to 6,000 mW, up to 6,250 mW, up to 6,500 mW, up to 6,750 mW, up to 7,000 mW, up to 7,250 mW, up to 7,500 mW, up to 7,750 mW, up to 8,000 mW, up to 8,250 mW, up to 8,500 mW, up to 8,750 mW, or up to 9,000 mW. In some embodiments, the high-power near-infrared light source is, for example, about 500 mW to about 1,000 mW, about 500 mW to about 1,500 mW, about 500 mW to about 2,000 mW, about 500 mW to about 2,500 mW, about 500 mW to about 3,000 mW, about 500 mW to about 3,500 mW, about 500 mW to about 4,000 mW, about 500 mW to about 4,500 mW, about 500 mW to about 5,000 mW, about 500 mW to about 5,500 mW, about 500 mW to about 6,000 mW, about 500 mW to about 6,500 mW, about 500 mW to about 7,000 mW, about 500 mW to about 7,500 mW, about 500 mW to about 8,000 mW, about 500 mW to about 8,500 mW, about 500 mW to about 9,000 mW, about 750 mW to about 1,000 mW, about 750 mW to about 1,500 mW, about 750 mW to about 2,000 mW, about 750 mW to about 2,500 mW, about 750 mW to about 3,000 mW, about 750 mW to about 3,500 mW, about 750 mW to about 4,000 mW, about 750 mW to about 4,500 mW, about 750 mW to about 5,000 mW, about 750 mW to about 5,500 mW, about 750 mW to about 6,000 mW, about 750 mW to about 6,500 mW, about 750 mW to about 7,000 mW, about 750 mW to about 7,500 mW, about 750 mW to about 8,000 mW, about 750 mW to about 8,500 mW, about 750 mW to about 9,000 mW, about 1,000 mW to about 1,500 mW, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 2,500 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 3,500 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 4,500 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 5,500 mW, about 1,000 mW to approximately 6,000 mW, approximately 1,000 mW to approximately 6,500 mW, approximately 1,000 mW to approximately 7,000 mW, approximately 1,000 mW to approximately 7,500 mW, approximately 1,000 mW to approximately 8,000 mW, approximately 1,000 mW to approximately 8,500 mW, approximately 1,000 mW to approximately 9,000 mW, approximately 1,500 mW to approximately 2,000 mW, approximately 1,500 mW to approximately 2,500 mW, approximately 1,500 mW to approximately 3,000 mW, approximately 1,500 mW to approximately 3,500 mW, approximately 1,500 mW to approximately 4,000 mW, approximately 1,500 mW to approximately 4,500 mW, approximately 1,500 mW to approximately 5,000 mW, approximately 1,500 mW to approximately 5,500 mW, approximately 1,500 mW to approximately 6,000 mW, approximately 1,500 mW to approximately 6,500 mW, approximately 1,500 mW to approximately 7,000 mW, approximately 1,500 mW to approximately 7,500 mW, approximately 1,500 mW to approximately 8,000 mW, approximately 1,500 mW to approximately 8,500 mW, approximately 1,500 mW to approximately 9,000 mW, approximately 2,000 mW to approximately 2,500 mW, approximately 2,000 mW to approximately 3,000 mW, approximately 2,000 mW to approximately 3,500 mW, approximately 2,000 mW to approximately 4,000 mW, approximately 2,000 mW to approximately 4,500 mW, approximately 2,000 mW to approximately 5,000 mW, approximately 2,000 mW to approximately 5,500 mW, approximately 2,000 mW to approximately 6,000 mW, approximately 2,000 mW to approximately 6,500 mW, approximately 2,000 mW to approximately 7,000 mW, approximately 2,000 mW to approximately 7,500 mW, approximately 2,000 mW to approximately 8,000 mW, approximately 2,000 mW to approximately 8,500 mW, approximately 2,000 mW to approximately 9,000 mW, approximately 2,500 mW to approximately 3,000 mW, approximately 2,500 mW to approximately 3,500 mW, approximately 2,500 mW to approximately 4,000 mW, approximately 2,500 mW to approximately 4,500 mW, approximately 2,500 mW to approximately 5,000 mW, approximately 2,500 mW to approximately 5,500 mW, approximately 2,500 mW to approximately 6,000 mW, approximately 2,500 mW to approximately 6,500 mW, approximately 2,500 mW to approximately 7,000 mW, approximately 2,500 mW to approximately 7,500 mW, approximately 2,500 mW to approximately 8,000 mW, approximately 2,500 mW to approximately 8,500 mW, approximately 2,500 mW to approximately 9,000 mW, approximately 3,000 mW to approximately 3,500 mW, approximately 3,000 mW to approximately 4,000 mW, approximately 3,000 mW to approximately 4,500 mW, approximately 3,000 mW to approximately 5,000 mW, approximately 3,000 mW to approximately 5,500 mW, approximately 3,000 mW to approximately 6,000 mW, approximately 3,000 mW to approximately 6,It has a radiation beam (output) of 500 mW, approximately 3,000 mW to approximately 7,000 mW, approximately 3,000 mW to approximately 7,500 mW, approximately 3,000 mW to approximately 8,000 mW, approximately 3,000 mW to approximately 8,500 mW, or approximately 3,000 mW to approximately 9,000 mW.,

[0044] In some embodiments, the high-power near-infrared light source has a radiation intensity (luminance) of, for example, about 50 mW / sr, about 100 mW / sr, about 150 mW / sr, about 200 mW / sr, about 250 mW / sr, about 300 mW / sr, about 350 mW / sr, about 400 mW / sr, about 450 mW / sr, about 500 mW / sr, about 550 mW / sr, about 600 mW / sr, about 650 mW / sr, about 700 mW / sr, or about 750 mW / sr. In some embodiments, the high-power near-infrared light source has a radiation intensity (luminance) of, for example, at least 50 mW / sr, at least 100 mW / sr, at least 150 mW / sr, at least 200 mW / sr, at least 250 mW / sr, at least 300 mW / sr, at least 350 mW / sr, at least 400 mW / sr, at least 450 mW / sr, at least 500 mW / sr, at least 550 mW / sr, at least 600 mW / sr, at least 650 mW / sr, at least 700 mW / sr, or at least 750 mW / sr. In some embodiments, the high-power near-infrared light source has a radiation intensity (luminance) of, for example, up to 50 mW / sr, up to 100 mW / sr, up to 150 mW / sr, up to 200 mW / sr, up to 250 mW / sr, up to 300 mW / sr, up to 350 mW / sr, up to 400 mW / sr, up to 450 mW / sr, up to 500 mW / sr, up to 550 mW / sr, up to 600 mW / sr, up to 650 mW / sr, up to 700 mW / sr, or up to 750 mW / sr.In some embodiments, the high-power near-infrared light source has a luminance range (or radiant intensity) of, for example, about 50 mW / sr to about 100 mW / sr, about 50 mW / sr to about 150 mW / sr, about 50 mW / sr to about 200 mW / sr, about 50 mW / sr to about 300 mW / sr, about 50 mW / sr to about 400 mW / sr, about 50 mW / sr to about 500 mW / sr, about 50 mW / sr to about 600 mW / sr, about 50 mW / sr to about 700 mW / sr, about 50 mW / sr to about 800 mW / sr, about 100 mW / sr to about 150 mW / sr, about 100 mW / sr to about 200 mW / sr, about 100 mW / sr to about 300 mW / sr, about 100 mW / sr to about 400 mW / sr, about 100 mW / sr to about 500 mW / sr, about 100 mW / sr to about 600 mW / sr, about 100 mW / sr to about 700 mW / sr, about 100 mW / sr to about 800 mW / sr, about 150 mW / sr to about 200 mW / sr, about 150 mW / sr to about 300 mW / sr, about 150 mW / sr to about 400 mW / sr, about 150 mW / sr to about 500 mW / sr, about 150 mW / sr to about 600 mW / sr, about 150 mW / sr to about 700 mW / sr, about 150 mW / sr to about 800 mW / sr, about 200 mW / sr to about 300 mW / sr, about 200 mW / sr to about 400 mW / sr, about 200 mW / sr to about 500 mW / sr, about 200 mW / sr to about 600 mW / sr, about 200 mW / sr to about 700 mW / sr, about 200 mW / sr to about 800 mW / sr, about 300 mW / sr to about 400 mW / sr, about 300 mW / sr to about 500 mW / sr, about 300 mW / sr to about 600 mW / sr, about 300 mW / sr to about 700 mW / sr, about 300 mW / sr to about 800 mW / sr, about 400 mW / sr to about 500 mW / sr, about 400 mW / sr to about 600 mW / sr, about 400 mW / sr to about 700 mW / sr, about 400 mW / sr to about 800 mW / sr, about 500 mW / sr to about 600 mW / sr, about 500 mW / sr to about 700 mW / sr, about 500 mW / sr to about 800 mW / sr, about 600 mW / sr to about 700 mW / sr, about 600 mW / sr to about 800 mW / sr, or about 700 mW / sr to about 800 mW / sr.

[0045] In some embodiments, the near-infrared light source 170 is a low-output infrared light source. In some embodiments, the low-output near-infrared light source has a radiant flux (output) of, for example, about 30 mW, about 35 mW, about 40 mW, about 45 mW, about 50 mW, about 55 mW, about 60 mW, about 65 mW, about 70 mW, or about 75 mW. In some embodiments, the low-output near-infrared light source has a radiant flux (output) of, for example, at least 30 mW, at least 35 mW, at least 40 mW, at least 45 mW, at least 50 mW, at least 55 mW, at least 60 mW, at least 65 mW, at least 70 mW, or at least 75 mW. In some embodiments, the low-output near-infrared light source has a radiant flux (output) of, for example, at most 30 mW, at most 35 mW, at most 40 mW, at most 45 mW, at most 50 mW, at most 55 mW, at most 60 mW, at most 65 mW, at most 70 mW, or at most 75 mW. In some embodiments, the low-output near-infrared light source has a radiant flux (output) of, for example, about 30 mW to about 40 mW, about 30 mW to about 50 mW, about 30 mW to about 60 mW, about 30 mW to about 70 mW, about 30 mW to about 75 mW, about 40 mW to about 50 mW, about 40 mW to about 60 mW, about 40 mW to about 70 mW, about 40 mW to about 75 mW, about 50 mW to about 60 mW, about 50 mW to about 70 mW, about 50 mW to about 75 mW, about 60 mW to about 70 mW, or about 60 mW to about 75 mW.

[0046] In some embodiments, the low-power near-infrared light source is configured to have a radiation intensity (luminance) of, for example, about 25 mW / sr, about 50 mW / sr, about 75 mW / sr, about 100 mW / sr, about 125 mW / sr, or about 150 mW / sr. In some embodiments, the low-power near-infrared light source has a luminance (or radiation intensity) of, for example, at least 25 mW / sr, at least 50 mW / sr, at least 75 mW / sr, at least 100 mW / sr, at least 125 mW / sr, or at least 150 mW / sr. In some embodiments, the near-infrared light source 170 has a radiation intensity (luminance) of, for example, up to 25 mW / sr, up to 50 mW / sr, up to 75 mW / sr, up to 100 mW / sr, up to 125 mW / sr, or up to 150 mW / sr. In some embodiments, the low-power near-infrared light source has a radiation intensity (luminance) of, for example, from about 25 mW / sr to about 50 mW / sr, from about 25 mW / sr to about 75 mW / sr, from about 25 mW / sr to about 100 mW / sr, from about 25 mW / sr to about 125 mW / sr, from about 25 mW / sr to about 150 mW / sr, from about 50 mW / sr to about 75 mW / sr, from about 50 mW / sr to about 100 mW / sr, from about 50 mW / sr to about 125 mW / sr, from about 50 mW / sr to about 150 mW / sr, from about 75 mW / sr to about 100 mW / sr, from about 75 mW / sr to about 125 mW / sr, from about 75 mW / sr to about 150 mW / sr, from about 100 mW / sr to about 125 mW / sr, from about 100 mW / sr to about 150 mW / sr, or from about 125 mW / sr to about 150 mW / sr.

[0047] Referring to FIGS. 10 to 17, 21, and 25, the photobiomodulation unit 100 also includes one or more sensors 180 configured to detect and collect information regarding one or more parameters including operation information of the photobiomodulation therapy clothing 20, biometric information of the user, or other useful information to ensure proper use and effectiveness. The operation information includes, but is not limited to, position information and safety information of the photobiomodulation therapy clothing 20. The biometric information includes, but is not limited to, body measurements and calculated values related to the user. Non-limiting examples of biosensors include nerve conduction sensors, galvanometer sensors, oxygen level sensors, carbon dioxide level sensors, cerebral oxygen level sensors, heart rate sensors, cortical blood flow sensors, temperature sensors, electroencephalogram sensors, or any combination thereof. The one or more sensors 180 can also measure, record, and analyze information and / or transmit it to the controller 200 if they are capable of performing measurement, recording, and analysis of the information.

[0048] In one or more embodiments, as shown in FIGS. 3-5, 10, 12, 16, and 17, the sensor cover 79 and one or more sensors 180 below or near it are disposed between the second near-infrared light source group 172 and the fifth near-infrared light source group 175. By this position, the sensor cover 79 and one or more sensors 180 below it are disposed substantially on the sagittal plane 320 of the frontal region. In some embodiments, if the second near-infrared light source group 172 and / or the fifth near-infrared light source group 175 do not exist, the sensor cover 79 and one or more sensors 180 below or near it can be disposed on the photobiomodulation therapy headband 22 in a position configured to dispose the sensor cover 79 substantially on the sagittal plane 320 when properly worn (see FIGS. 13-15, 18, 21, 22, and 25). In some embodiments, the sensor cover 79 and one or more sensors 180 below or near it are disposed between the first near-infrared light source group 171 and the fourth near-infrared light source group 174. In some embodiments, the sensor cover 79 and one or more sensors 180 below or near it are disposed between the third near-infrared light source group 173 and the sixth near-infrared light source group 176. In some embodiments, if two sensors 180 need to be separated for proper functioning, one sensor cover 79 and one or more sensors 180 below or near it are disposed between the first near-infrared light source group 171 and the fourth near-infrared light source group 174 (or outside such a group in the direction towards the left side portion 56), and one sensor cover 79 and one or more sensors 180 below or near it are disposed between the third near-infrared light source group 173 and the sixth near-infrared light source group 176 (or outside such a group in the direction towards the right side portion 54).

[0049] In some embodiments, sensor 180 includes a heart rate sensor and a temperature sensor. Referring to FIGS. 10 and 12-17, 21, and 25, one or more sensors 180 include a cardiovascular sensor 182 that detects blood flow pulse wave, oxygen level, and other cardiovascular characteristics. Referring to FIG. 11, which is a longitudinal cross-section of the sensor attachment portion 142, the cardiovascular sensor 182 includes LED light sources 184, 186 and a photodetector 188. The light from the LED light sources 184, 186 is irradiated onto the blood vessels directly under the skin surface S, and the portion of the reflected light that returns is captured by the photodetector 188. The signal from the cardiovascular sensor 182 is transmitted to the controller 200 to determine the user's cardiovascular parameters. Similarly, referring to FIGS. 10 and 12-17, 21, and 25, one or more sensors 180 include a temperature sensor 192 that detects skin parameters such as, for example, skin temperature, skin density, and skin opacity (color). The signal from the temperature sensor 192 is transmitted to the controller 200 to determine the user's skin parameters.

[0050] The photobiomodulation unit 100 can optionally include one or more stimulation devices 194 configured to apply brain stimulation or inhibition signals. Non-limiting examples of stimulation devices include transcranial direct current stimulation devices and transcranial magnetic stimulation devices. A transcranial direct current stimulation device is a component capable of generating a direct current useful for stimulating a specific part of the brain containing nerve cells. Such a current generating component can be used to perform transcranial direct current stimulation (tDCS) therapy. A transcranial magnetic stimulation device is a component capable of generating a magnetic field useful for stimulating nerve cells in the brain, such as a magnetic material (electromagnet) of a material that can be magnetized using an electric current. Such a magnetic field generating component can be used to perform transcranial magnetic stimulation (TMS) therapy. In some embodiments, referring to FIGS. 21 and 25, one or more stimulation devices 194 are operably attached to an electronic circuit connector 162 or a liquid wire tube 158 for sensors that includes the electronic circuitry necessary to establish electrical communication between each of the one or more stimulation devices 194 and the connection terminals 160.

[0051] Referring to FIGS. 1, 2, 7, 8, 19, 23, and 27 - 31, the clothing 20 for photobiomodulation therapy also includes a controller 200. In one or more embodiments, the controller 200 includes a housing that houses an input section, a hardware processor, a memory, and an output section, and may include each of one or more of these elements. In one or more exemplary embodiments, the controller 200 may include a single - board computer, a system - on - chip, or other similar and / or known computing device or circuit. The input section can include one or more USB connectors and / or short - range wireless devices (e.g., a BLUETOOTH module, a Wi - Fi module, or other wireless communication device or system) for communicating with external computers such as smartphones, desktops, laptops, tablets, other wearable computing devices, and servers. The controller 200 can operate autonomously or semi - autonomously, or can read executable software instructions, code, or other information from a memory or computer - readable medium, or can receive information or instructions via the input section from a user, a healthcare provider, or any other source logically connected to a computer or device such as another networked computer, server, or a computer or device such as an artificial intelligence (AI) or machine - learning system. In some embodiments, the controller 200 can be remotely accessed and operated by a third - party individual such as a healthcare professional who can monitor the use of the clothing 20 for photobiomodulation therapy, change its operating parameters, and / or collect data therefrom, thereby providing a remote digital healthcare platform to assist the user in receiving the most effective biomodulation therapy.In some embodiments, the controller 200 can be a "virtual controller", in which case the access to and operation of the photobiomodulation therapy garment 20 by the controller 200 is performed via cloud computing elements by any other source logically connected to a computer or device, such as a healthcare provider, or another networked computer or server or an AI or machine learning-based system. The controller 200 can be evaluated and operated by pre-programmed instructions and / or parameters, real-time instructions and / or parameters, or both.

[0052] The controller 200 is programmed to supply electrical signals that provide power to each of the one or more near-infrared light sources 170, each of the one or more sensors 180, and each of the one or more stimulation devices 194. Additionally, the controller 200 in one or more embodiments is a computing device programmed or configured to implement methods and algorithms that can operably control each of the one or more near-infrared light sources 170, each of the one or more sensors 180, and each of the one or more stimulation devices 194. For example, in some embodiments, the controller 200 controls the operating time of the one or more near-infrared light sources 170, the fluence level of the one or more near-infrared light sources 170, the irradiance level of the one or more near-infrared light sources 170, whether the one or more near-infrared light sources 170 operate continuously or in a pulsed manner, which of the one or more near-infrared light sources 170 are activated or deactivated, and one or more of a predetermined dose measurement level. Additionally, the controller 200 operably controls each of the one or more sensors 180 and receives and analyzes information collected from each of the one or more sensors 180. In some embodiments, the controller 200 operably controls the operating time of the one or more stimulation devices 194, the output level of the one or more stimulation devices 194, whether the one or more stimulation devices 194 operate continuously or in a pulsed manner, which of the one or more stimulation devices 194 are activated or deactivated, or one or more of any combination thereof.

[0053] In some embodiments, referring now to FIGS. 26 - 28, the controller 200 includes a housing including a front housing portion 202 and a rear housing portion 204, a control assembly 210, and a heat dissipation material 230. The outer surface of the front housing portion 202 includes an on - off button 206 and an indicator window 208. The rear housing portion 204 includes a reversibly removable cover 205 that exposes a connection terminal 212 having a rail mount 214 and contacts 216 when removed. The rail mount 214 is configured to reversibly and securely engage with a terminal rail mount 164 of the connection terminal 160 of the photobiomodulation therapy garment 20 when the user decides to attach the controller 200 to the photobiomodulation therapy garment 20. When the rail mount 214 securely engages with the terminal rail mount 164, the contacts 216 of the rail mount 214 directly contact the contacts 166 of the terminal rail mount 164 to establish electrical communication between the controller 200 and the photobiomodulation therapy garment 20. As best seen in FIGS. 28 and 30, the front housing 202 and the rear housing 204 form ports that allow access to a cable connector 228, such as a USB - A, USB - B, USB - C, micro - USB, and Lightning. The cable connector 228 is configured to connect to a power source to enable charging of a rechargeable battery.

[0054] The control assembly 210 includes a rechargeable power source and one or more printed circuit boards. In some embodiments, as shown in FIGS. 29-31, the control assembly 210 includes a rechargeable power source 220 that supplies power necessary to operate the controller 200, and printed circuit boards 222, 222' that provide a substrate and housing for the electrical circuits necessary to operate the various components of the controller 200. Power is supplied to the printed circuit boards 222, 222' via a power induction component 218 configured to transfer power from the rechargeable power source 220 to the printed circuit boards 222, 222'. In this exemplary embodiment, the connection terminal 210 is disposed on the rear surface of the printed circuit board 222 to provide the necessary electronic communication for the connection terminal 212 to communicate with the terminal 160, and to provide the necessary electronic communication for the operation of the system chip 223, the on / off switch 224, the cable connector 228, and the antenna 229, while the power induction component 218, the system chip 223, the on / off switch 224, the cable connector 229, and the antenna 229 are each disposed on the front surface of the printed circuit board 222. The light source 226 is disposed on a printed circuit board 222' that provides a substrate and housing for the electrical circuit necessary for the operation of the light source 226. The antenna 229 is configured to enable wireless communication between the controller 200 and another device.

[0055] Referring now to FIG. 28, during the assembly of the controller 200, a heat dissipation material 230, such as a copper film, is positioned with a notch of the heat dissipation material 230 aligned with an opening in the rear housing portion 204 such that the contact 216 of the control terminal 212 is evaluable against the contact 166 when assembled, and is disposed on the inner surface of the rear housing portion 204. Next, the control assembly 210 is fixed to the rear housing portion 204 with the contact 216 of the control terminal 212 aligned with the notch of the heat dissipation material 230 and the opening in the rear housing portion 204, and with the on / off switch 224 aligned with the on / off button 206, the light source 226 aligned with the display light window 208, and the cable connector 228 aligned with the port for the cable connector 228.

[0056] In some embodiments, the controller 200 is operably commanded to activate one or more infrared light sources 170 on the left side of the midsagittal plane 320 and deactivate one or more infrared light sources 170 on the right side of the midsagittal plane 320, or vice versa. In some embodiments, the controller 200 activates one or more infrared light sources 170 on the left side of the midsagittal plane 320 at a higher level of irradiance than one or more infrared light sources 170 on the right side of the midsagittal plane 320, or vice versa, while operably commanding the activation of one or more infrared light sources 170 on both the left and right sides of the midsagittal plane 320.

[0057] In some embodiments, the controller 200 dynamically adjusts the operating parameters of the photobiomodulation therapy garment 20 using information collected from each of the one or more sensors 180, information provided by the user, or information remotely input by an individual third party. At that time, such input information is processed by the controller 200 against information stored in the operation database by one or more algorithms, and based on the analysis performed when comparing the collected or provided or input information with the information stored in such a database using one or more algorithms, the operating parameters of each of the one or more near-infrared light sources 170, each of the one or more sensors 180, and each of the one or more stimulation devices 194 are adjusted by executable instructions provided to the controller 200.

[0058] For example, cardiovascular sensor 182 acquires cardiovascular parameters from the user during operation of the clothing 20 for photobiomodulation therapy, and this input information is analyzed against cardiovascular parameters stored in the operation database to evaluate the actual cardiovascular parameters based on the therapy selected by the user or an individual third party and to adjust the operation of the clothing 20 for photobiomodulation therapy. In some embodiments, when a decrease in heart rate variability is detected by cardiovascular sensor 182 and transmitted to controller 200, controller 200 provides executable instructions to optimize the pulse wave by increasing the frequency of the light emitted from one or more near-infrared light sources 170 in the situation where the user or an individual third party has selected the arousal therapy. By way of example, the initial pulse wave of the clothing 20 for photobiomodulation therapy can be set to 40 Hz, and based on the detected heart rate variability, controller 200 increases the frequency of the light emitted from one or more near-infrared light sources 170 to 50 Hz. Continuous monitoring and analysis of heart rate variability by cardiovascular sensor 182 and controller 200 allows the 50 Hz pulse wave setting to be maintained, or increased to 60 Hz or 70 Hz or higher, in order to cause an appropriate pulse wave for the arousal therapy to be emitted from one or more near-infrared light sources 170. Such dynamic monitoring of heart rate variability by cardiovascular sensor 182 and controller 200 results in continuous adjustment of the pulse wave to achieve the optimal pulse wave for the selected arousal therapy.

[0059] In one embodiment, when an increase in heart rate variability is detected by the cardiovascular sensor 182 and transmitted to the controller 200, the controller 200 provides executable instructions to optimize the pulse wave by decreasing the frequency of the light emitted from one or more near-infrared light sources 170 in a situation where the user or a third-party individual has selected a sedation or relaxation therapy. By way of example, the initial pulse wave of the photobiomodulation therapy garment 20 can be set to 40 Hz, and based on the detected heart rate variability, the controller 200 decreases the frequency of the light emitted from one or more near-infrared light sources 170 to 30 Hz. Through continuous monitoring and analysis of the heart rate variability by the cardiovascular sensor 182 and the controller 200, the 30 Hz pulse wave setting is maintained, or decreased to 10 Hz or 1 Hz, in order to cause an appropriate pulse wave for sedation or relaxation therapy to be emitted from one or more near-infrared light sources 170. Such dynamic monitoring of the heart rate variability by the cardiovascular sensor 182 and the controller 200 results in continuous adjustment of the pulse wave to achieve the optimal pulse wave for the selected sedation or relaxation therapy.

[0060] As another example, the skin sensor 192 acquires information regarding skin parameters from the user during operation of the photobiomodulation therapy garment 20, and this input information is analyzed against skin information stored in the operation database to evaluate the actual skin parameters based on the therapy selected by the user or a third-party individual and to adjust the operation of the photobiomodulation therapy garment 20. In some embodiments, when a decrease in skin temperature is detected by the skin sensor 192 and transmitted to the controller 200, the controller 200 provides executable instructions to optimize the skin temperature by increasing the irradiance of the light emitted from one or more near-infrared light sources 170 in a situation where the user or a third-party individual has selected an arousal therapy. By way of example, the initial irradiance of the photobiomodulation therapy garment 20 is 250 mW / cm 2It can be set to, and based on the detected skin temperature, the controller 200 can adjust the irradiance of the light emitted from one or more near-infrared light sources 170 to 500 mW / cm 2 and increase it. Through continuous monitoring and analysis of the skin temperature by the skin sensor 192 and the controller 200, in order to establish an appropriate skin temperature for the arousal therapy, the irradiance setting of 500 mW / cm 2 can be maintained, or increased to 750 mW / cm 2 or 1000 mW / cm 2 or higher. Such dynamic monitoring of the skin temperature by the skin sensor 192 and the controller 200 results in continuous adjustment of the irradiance to achieve the optimal skin temperature for the selected arousal therapy.

[0061] In some embodiments, when an increase in skin temperature is detected by the skin sensor 192 and transmitted to the controller 200, in a situation where the user or a third party individual has selected a sedation or relaxation therapy, the controller 200 provides executable instructions to optimize the skin temperature by reducing the irradiance of the light emitted from one or more near-infrared light sources 170. By way of example, the initial irradiance of the photobiomodulation therapy clothing 20 can be set to 250 mW / cm 2 and based on the detected skin temperature, the controller 200 can reduce the irradiance of the light emitted from one or more near-infrared light sources 170 to 100 mW / cm 2 and reduce it. Through continuous monitoring and analysis of the skin temperature by the skin sensor 192 and the controller 200, in order to establish an appropriate skin temperature for the sedation or relaxation therapy, the irradiance setting of 125 mW / cm 2 can be maintained, or reduced to 75 mW / cm 2 or 25 mW / cm 2 or lower. Such dynamic monitoring of the skin temperature by the skin sensor 192 and the controller 200 results in continuous adjustment of the irradiance to achieve the optimal skin temperature for the selected sedation or relaxation therapy.

[0062] In some embodiments, when a decrease in skin temperature is detected by the skin sensor 192 and transmitted to the controller 200, the controller 200 provides executable instructions to optimize the skin temperature by increasing the duty cycle of the light emitted from one or more near-infrared light sources 170 in situations where a user or a third-party individual has selected the arousal therapy. By way of example, the initial duty cycle of the clothing 20 for photobiomodulation therapy can be set to 50%, and based on the detected skin temperature, the controller 200 increases the duty cycle of the light emitted from one or more near-infrared light sources 170 to 60%. Through the continuous monitoring and analysis of the skin temperature by the skin sensor 192 and the controller 200, the 60% duty cycle setting can be maintained or increased to 75% or more in order to establish an appropriate skin temperature for the arousal therapy. Such dynamic monitoring of the skin temperature by the skin sensor 192 and the controller 200 results in a continuous adjustment of the duty cycle to achieve the optimal skin temperature for the selected arousal therapy.

[0063] In some embodiments, when a skin temperature increase is detected by skin sensor 192 and transmitted to controller 200, controller 200 provides executable instructions to optimize the skin temperature by reducing the duty cycle of the light emitted from one or more near-infrared light sources 170 in situations where the user or a third-party individual has selected a calming or relaxation therapy. By way of example, the initial duty cycle for the photobiomodulation therapy garment 20 can be set to 50%, and based on the detected skin temperature, controller 200 reduces the duty cycle of the light emitted from one or more near-infrared light sources 170 to 40%. Continued monitoring and analysis of the skin temperature by skin sensor 192 and controller 200 allows the 40% duty cycle setting to be maintained or reduced to 25% or less in order to establish an appropriate skin temperature for the arousal therapy. Such dynamic monitoring of the skin temperature by skin sensor 192 and controller 200 results in a continuous adjustment of the duty cycle to achieve an optimal skin temperature for the selected calming or relaxation therapy.

[0064] In some embodiments, when a higher skin opacity representing skin with a higher melanin content is detected by the skin sensor 192 and transmitted to the controller 200, the controller 200 provides executable instructions to optimize skin transmission by adjusting the wavelength, or combination of wavelengths, of the light emitted from one or more near-infrared light sources 170 to provide optimal light transmission for the selected therapy. By way of example, the initial wavelength of the photobiomodulation therapy garment 20 can be set to 900 nm, and based on the detected skin opacity, the controller 200 increases the wavelength of the light emitted from one or more near-infrared light sources 170 to about 970 nm. Continuous monitoring and analysis of skin opacity by the skin sensor 192 and the controller 200 can maintain the wavelength setting or increase it to above 1000 nm to establish appropriate wavelength transmission through the skin for the selected therapy. Such dynamic monitoring of skin opacity by the skin sensor 192 and the controller 200 results in continuous adjustment of the wavelength to achieve optimal skin transmission for the selected therapy.

[0065] In some embodiments, when a lower skin opacity representing skin with a lower melanin content is detected by the skin sensor 192 and transmitted to the controller 200, the controller 200 provides executable instructions to optimize skin transmission by adjusting the wavelength, or combination of wavelengths, of the light emitted from one or more near-infrared light sources 170 to provide optimal light transmission for the selected therapy. By way of example, the initial wavelength of the photobiomodulation therapy garment 20 can be set to 900 nm, and based on the detected skin opacity, the controller 200 decreases the wavelength of the light emitted from one or more near-infrared light sources 170 to about 810 nm. Continuous monitoring and analysis of skin opacity by the skin sensor 192 and the controller 200 can maintain the wavelength setting or decrease it to below 790 nm to establish appropriate wavelength transmission through the skin for the selected therapy. Such dynamic monitoring of skin opacity by the skin sensor 192 and the controller 200 results in continuous adjustment of the wavelength to achieve optimal skin transmission for the selected therapy.

[0066] In some embodiments, when a higher skin density representing skin with a higher fat content is detected by the skin sensor 192 and transmitted to the controller 200, the controller 200 provides executable instructions to optimize skin penetration by adjusting the wavelength of the light emitted from one or more near-infrared light sources 170 to provide optimal light penetration for the selected therapy. By way of example, the initial wavelength of the photobiomodulation therapy garment 20 can be set to 900 nm, and based on the detected skin density, the controller 200 increases the wavelength of the light emitted from one or more near-infrared light sources 170 to about 970 nm. Through continuous monitoring and analysis of the skin density by the skin sensor 192 and the controller 200, the wavelength setting can be maintained or increased to above 1000 nm to establish appropriate wavelength penetration into the skin for the selected therapy. Such dynamic monitoring of the skin density by the skin sensor 192 and the controller 200 results in continuous adjustment of the wavelength to achieve optimal skin penetration for the selected therapy.

[0067] In some embodiments, when a lower skin density representing skin with a lower fat content is detected by the skin sensor 192 and transmitted to the controller 200, the controller 200 provides executable instructions to optimize skin penetration by adjusting the wavelength of the light emitted from one or more near-infrared light sources 170 to provide optimal light penetration for the selected therapy. By way of example, the initial wavelength of the photobiomodulation therapy garment 20 can be set to 900 nm, and based on the detected skin density, the controller 200 decreases the wavelength of the light emitted from one or more near-infrared light sources 170 to about 810 nm. Through continuous monitoring and analysis of the skin density by the skin sensor 192 and the controller 200, the wavelength setting can be maintained or decreased to below 790 nm to establish appropriate wavelength penetration into the skin for the selected therapy. Such dynamic monitoring of the skin density by the skin sensor 192 and the controller 200 results in continuous adjustment of the wavelength to achieve optimal skin penetration for the selected therapy.

[0068] As another example, during operation of the photobiomodulation therapy clothing 20, information can be provided by the user or an individual third party, and this input information is either directly used to adjust the operation of the photobiomodulation therapy clothing 20 based on the therapy selected by the user, or analyzed against user-defined or individual third-party-defined information stored in the operation database to adjust the operation of the photobiomodulation therapy clothing 20 based on the selected therapy. By way of example, the initial therapy of the photobiomodulation therapy clothing 20 can be set to an awakening therapy, and based on user input (e.g., "still tired" or "comfortable", etc.) or individual third-party input (e.g., based on monitoring of the user's physiology or vital signs), the controller 200 adjusts the characteristics of the light emitted from one or more near-infrared light sources 170. Continuous input from the user or an individual third party to the controller 200 establishes the appropriate light characteristics for the selected awakening therapy. Such dynamic monitoring of the input from the user or an individual third party to the controller 200 results in continuous adjustment of the light characteristics to achieve the optimal effect of the selected awakening therapy. As another example, if the treatment is a prescribed therapy, the photobiomodulation therapy clothing 20 is activated and commands can be provided by an individual third party to schedule treatment parameters such as average irradiance, peak irradiance, average fluence, peak fluence, total incident energy during the treatment session, total output over the treatment area, duration of the treatment session, whether the modulation mode is pulsed operation or continuous operation, duty cycle, exposure area, frequency of multiple treatments, or any combination thereof. In this example, the user only needs to wear the photobiomodulation therapy clothing 20 at the appropriate time and place.

[0069] As another example, sensor 180 acquires information regarding mitochondrial function from the user during the operation of the photobiomodulation therapy clothing 20, and this input information is analyzed against mitochondrial function information stored in the operation database to evaluate the actual mitochondrial function based on the therapy selected by the user or an individual third party, and to adjust the operation of the photobiomodulation therapy clothing 20. By way of example, the initial therapy of the photobiomodulation therapy clothing 20 can be set to an arousal therapy, and based on the detected mitochondrial function (e.g., NAD + or NADH level, etc.), the controller 200 adjusts the characteristics of the light emitted from one or more near-infrared light sources 170. Through the continuous monitoring and analysis of skin opacity by the sensor 180 and the controller 200, the appropriate light characteristics for the selected arousal therapy emitted from one or more near-infrared light sources 170 are established. Such dynamic monitoring of mitochondrial function by the sensor 180 and the controller 200 results in a continuous adjustment of the light characteristics to achieve optimal skin penetration of the selected arousal therapy.

[0070] The adjustments described in the example of the above paragraph performed by the controller 200, and the processes executed thereon for various types of information, are provided as inputs within a model trained with past or known data such as that stored in the operation database mentioned above to improve such adjustments of the operation parameters of each of the one or more near-infrared light sources 170, each of the one or more sensors 180, and each of the one or more stimulation devices 194, and can be executed in conjunction with an element of artificial intelligence (AI) that analyzes the information. Accordingly, the present invention may include such a machine learning-based framework that can be composed of a plurality of elements that execute some of the processing modes executed by the controller 200 as models instantiated together or separately.

[0071] Modeling performed within a machine learning-based framework includes many different types of machine learning, analyzes information, and applies many different mathematical techniques to improve the output that results in the continuous adjustment of the operating parameters of each of one or more near-infrared light sources 170, each of one or more sensors 180, and each of one or more stimulation devices 194 described herein. For example, in some embodiments of the present invention, the machine learning-based framework may be composed of algorithms that apply supervised learning, reinforcement learning, and techniques of other methods of machine learning and artificial intelligence to further evaluate the input to the controller 200.

[0072] The machine learning-based framework can be composed of any of several different mathematical techniques. These can include statistical analysis, which is a non-deterministic mathematical technique that enables the calculation of the probability that an event will occur or will not occur. Regression analysis is a type of statistical analysis in which a model is used to estimate the relationship between variables of interest, such as a dependent variable and one or more independent variables (often called "predictors"). This type of machine learning infers the causal relationship between the independent and dependent variables and is used for prediction and anticipation of results that will have a significant impact on future states with respect to the application of the overall modeling in which such causal relationships are being executed. There are many types of regression analysis, such as linear and non-linear regression, and specific techniques such as logistic regression, which allow the use of derived parameters to interpret the importance of maximum values in the form of log odds when calculating probability values. For example, other types of logistic functions, and other types of regression analysis, may also be utilized in the present invention to calculate probabilities and are within the scope of the present invention. Other techniques that may be utilized include, but are not limited to, decision trees, random forest classifiers, support vector machines, and probits. Thus, it should be further understood that the present invention and this specification should not be limited to any one type of the mathematical models or statistical processes referred to herein, particularly with respect to their application in one or more layers of machine learning.

[0073] Modeling within a machine learning-based framework may also include the application of neural networks. A neural network generally consists of nodes that are computational units having one or more biased input / output connections. Such bias connections function as transfer (or activation) functions that combine inputs and outputs in some way. The nodes are organized into multiple layers that form the neural network. There are many types of neural networks that are computing systems that "learn" to perform tasks without being programmed with task-specific rules, based on examples.

[0074] A neural network generally is based on an array of connected aggregation nodes (or, "neurons") that transmit signals to each other in multiple layers via biased input / output connections. The connections are activation or transfer functions that "fire" these nodes and combine inputs according to a mathematical equation or formula. Different types of neural networks generally have different configurations of these layers of connected aggregation nodes, but they can generally be described as an input layer, an intermediate or "hidden" layer, and an output layer. These layers can perform different transformations on their various inputs using different mathematical computations or functions.

[0075] Signals are transmitted between nodes via connections, and the output of each node is calculated by a non-linear function that sums all of the inputs to that node. Weight matrices and biases are typically applied to each node and each connection, and these weights and biases are adjusted as the neural network processes the inputs and transmits them across the nodes and connections. These weights represent an increase or decrease in the strength of a signal at a particular connection. Additionally, a node may have a threshold, and a signal is transmitted only if the aggregated output of that node exceeds that threshold. The weights generally represent how long an activation function takes, while the bias represents when such a function starts in time, and together they help the gradient to be minimized over time. At least in the case of the weights, they can be initialized and change (i.e., decay) over time as the system learns which weights should be adjusted and how they should be adjusted. In other words, the neural network evolves as it learns, and the mathematical formulas and functions, including the neural network design, can change over time as the system improves itself.

[0076] The application of neural networks within a machine learning-based framework can involve the instantiation of different networks for different purposes. These include both "production" neural networks configured to improve the algorithms executed within an overall modeling framework to generate output data (e.g., as adjusted operating parameters of each of one or more near-infrared light sources 170, one or more sensors 180, and one or more stimulation devices 194), and "training" neural networks configured to train the production network using improvements based on learned past results.

[0077] A recurrent neural network is a name given to a type of neural network in which the connections between nodes follow a directed time sequence, enabling the neural network to model temporal dynamics and process sequences of variable-length inputs. These types of neural networks are deployed when they need to recognize and / or act on such sequences. As with general neural networks, there are many types of recurrent neural networks.

[0078] Neural networks with recurrent architectures also have a memory or controlled internal state that enables storage under the direct control of the neural network, which can be made suitable by inputs having a temporal nature. This storage can be in the form of connections or gates that function as time delays or feedback loops that enable nodes or connections to hold previous data in time to model such temporal dynamics. Such a controlled internal state is called a gate state or gated memory and is part of long short-term memory (LSTM) and gated recurrent unit (GRU), which are names for different types of recurrent neural network architectures. This type of neural network design is utilized when the desired output of the system is motivated by the need for memory as storage and when, as pointed out above, the system is designed to process inputs composed of time-specified data sequences. Examples of such time-specified data sequences include video, speech recognition, and handwriting, which require the analysis of data that changes over time. In the present invention, when the output data is in the form of the operating parameters of each of one or more near-infrared light sources 170, one or more sensors 180, and one or more stimulation devices 194, understanding the influence of various events on the state over a period of time can result in more accurate and reliable operating parameters that can at least affect the amount of time for which the stimulation is provided.

[0079] There are many other types of recurrent neural networks. These include, for example, fully recurrent neural networks, Hopfield networks, bidirectional associative memory networks, echo state networks, and neural Turing machines, all of which exhibit the ability to model temporal dynamics. Any instantiation of such neural networks in the present invention may include one or more of these types, and it should be understood that neural networks applied within a machine learning-based framework may include different ones of such types. Thus, the present invention contemplates that many types of neural networks may be implemented, at least depending on the type of problem being analyzed.

[0080] The controller 200 is reversibly connected to the photobiomodulation therapy garment 20 by operably engaging the terminal rail mount 164. The controller 200 may optionally include a rechargeable battery disposed within the housing. The controller 200 can be removed from the terminal rail mount 164 to charge the rechargeable battery therein using a charging connector such as a USB-C or micro USB. Further, the charging connector can provide wired data communication with a remote computer such as a smartphone, laptop, desktop, or other computer device. In one or more embodiments, this enables tracking of usage and / or updating or changing of operating parameters such as desired dose measurements, duration, adjustment of the modulation mode to a pulsed or continuous operation, and / or updating of the controller firmware, and / or changing the type of the photobiomodulation therapy garment 20 to which the controller 200 is attached. The controller 200 can be a general-purpose controller such that the controller 200 can be connected to a plurality of embodiments of the photobiomodulation therapy garment 20, such as a photobiomodulation therapy headband 22, a garment for the neck region, a garment for the posterior neck region, a garment for the shoulder region, a garment for the palm root region, a garment for the abdominal region, and a garment for the back region, each configured to cover a respective region when worn.

[0081] One or more near-infrared light sources 170 of the photobiomodulation unit 100 can be arranged in one or more separate near-infrared light source groups in a pattern among several groups relative to each other and arranged over one or more regions of interest of the skin region S to be treated by photobiomodulation therapy. For example, there can be, for example, one near-infrared light source group, two near-infrared light source groups, three near-infrared light source groups, four near-infrared light source groups, five near-infrared light source groups, six near-infrared light source groups, seven near-infrared light source groups, eight near-infrared light source groups, nine near-infrared light source groups, or ten near-infrared light source groups. Each near-infrared light source group is spaced apart from adjacent groups, and the spacing between groups can be the same among each near-infrared light source group, or can be varied according to a desired dose measurement and according to the relative position of the desired region of interest. The relative pattern of the near-infrared light source groups is configured to arrange each group on the photobiomodulation therapy clothing 20 so as to at least partially cover each region of interest on the skin surface S, which may appear to be a random pattern to an observer not of interest. As shown in FIG. 4, the spacing of the pattern between each near-infrared light source group can be defined by a vertical row distance d1 and a horizontal row distance d2. The inter-group distance can be measured from the center of the light source. In one or more embodiments, the vertical row distance d1 and the horizontal row distance d2 are at least 5 mm, or at least 10 mm, or at least 15 mm, or at least 20 mm, or at least 25 mm, or at least 30 mm, or at least 35 mm, or at least 40 mm. In a rectangular array, the horizontal row distance d2 can be the same distance as the vertical row distance d1 or can be different from the vertical row distance d1.

[0082] In some embodiments, one or more skin regions S to be effectively covered by the pattern between groups of one or more near-infrared light sources 170 are, for example, about 10 cm 2 , about 15 cm 2 , about 20 cm 2 , about 25 cm 2 , about 30 cm 2 , about 35 cm2 , approximately 40 cm 2 , approximately 45 cm 2 , approximately 50 cm 2 , approximately 55 cm 2 , or approximately 60 cm 2 includes a total area of. In some embodiments, one or more skin regions S to be effectively covered by the inter-group pattern of one or more near-infrared light sources 170 are, for example, at least 10 cm 2 , at least 15 cm 2 , at least 20 cm 2 , at least 25 cm 2 , at least 30 cm 2 , at least 35 cm 2 , at least 40 cm 2 , at least 45 cm 2 , at least 50 cm 2 , at least 55 cm 2 , or at least 60 cm 2 includes a total area of. In some embodiments, one or more skin regions S to be effectively covered by the inter-group pattern of one or more near-infrared light sources 170 are, for example, at most 10 cm 2 , at most 15 cm 2 , at most 20 cm 2 , at most 25 cm 2 , at most 30 cm 2 , at most 35 cm 2 , at most 40 cm 2 , at most 45 cm 2 , at most 50 cm 2 , at most 55 cm 2 , or at most 60 cm 2 includes a total area of. In some embodiments, one or more skin regions S to be effectively covered by the inter-group pattern of one or more near-infrared light sources 170 are, for example, about 10 cm 2 ~ about 15 cm 2 , about 10 cm 2 ~ about 20 cm 2 , about 10 cm 2 ~ about 25 cm 2 , about 10 cm 2 ~ about 30 cm 2 , about 10 cm 2 ~ about 35 cm 2, about 10 cm 2 ~ about 40 cm 2 , about 10 cm 2 ~ about 45 cm 2 , about 10 cm 2 ~ about 50 cm 2 , about 10 cm 2 ~ about 55 cm 2 , about 10 cm 2 ~ about 60 cm 2 , about 15 cm 2 ~ about 20 cm 2 , about 15 cm 2 ~ about 25 cm 2 , about 15 cm 2 ~ about 30 cm 2 , about 15 cm 2 ~ about 35 cm 2 , about 15 cm 2 ~ about 40 cm 2 , about 15 cm 2 ~ about 45 cm 2 , about 15 cm 2 ~ about 50 cm 2 , about 15 cm 2 ~ about 55 cm 2 , about 15 cm 2 ~ about 60 cm 2 , about 20 cm 2 ~ about 25 cm 2 , about 20 cm 2 ~ about 30 cm 2 , about 20 cm 2 ~ about 35 cm 2 , about 20 cm 2 ~ about 40 cm 2 , about 20 cm 2 ~ about 45 cm 2 , about 20 cm 2 ~ about 50 cm 2 , about 20 cm 2 ~ about 55 cm 2 , about 20 cm 2 ~ about 60 cm 2 , about 25 cm 2 ~ about 30 cm 2 , about 25 cm 2 ~ about 35 cm 2 , about 25 cm 2 ~ about 40 cm 2 , about 25 cm 2 ~ about 45 cm 2 , about 25 cm2 ~ about 50 cm 2 , about 25 cm 2 ~ about 55 cm 2 , about 25 cm 2 ~ about 60 cm 2 , about 30 cm 2 ~ about 35 cm 2 , about 30 cm 2 ~ about 40 cm 2 , about 30 cm 2 ~ about 45 cm 2 , about 30 cm 2 ~ about 50 cm 2 , about 30 cm 2 ~ about 55 cm 2 , about 30 cm 2 ~ about 60 cm 2 , about 35 cm 2 ~ about 40 cm 2 , about 35 cm 2 ~ about 45 cm 2 , about 35 cm 2 ~ about 50 cm 2 , about 35 cm 2 ~ about 55 cm 2 , about 35 cm 2 ~ about 60 cm 2 , about 40 cm 2 ~ about 45 cm 2 , about 40 cm 2 ~ about 50 cm 2 , about 40 cm 2 ~ about 55 cm 2 , about 40 cm 2 ~ about 60 cm 2 , about 45 cm 2 ~ about 50 cm 2 , about 45 cm 2 ~ about 55 cm 2 , about 45 cm 2 ~ about 60 cm 2 , about 50 cm 2 ~ about 55 cm 2 , about 50 cm 2 ~ about 60 cm 2 , or about 55 cm 2 ~ about 60 cm 2 including the total area of.

[0083] In some embodiments, the photobiomodulation unit 100 of the photobiomodulation therapy garment 20 comprises one or more groups of near-infrared light sources. Each of the one or more groups of near-infrared light sources is arranged in a pattern configured to direct each light source towards a particular region of interest when the photobiomodulation therapy garment 20 is correctly positioned over the forehead of a person P. In some embodiments, the photobiomodulation unit 100 is such that when the photobiomodulation therapy garment 20 is properly worn, each of the one or more groups of near-infrared light sources is arranged such that it at least partially overlaps or is substantially centered on the main meridians, the major extraordinary meridians, the minor extraordinary meridians, or any combination thereof. The main meridians include, but are not limited to, the heart meridian, the pericardium meridian, the lung meridian, the spleen meridian, the liver meridian, the kidney meridian, the small intestine meridian, the large intestine meridian, the triple energizer meridian, the stomach meridian, the gallbladder meridian, and the bladder meridian. The major extraordinary meridians include, but are not limited to, the conception vessel and the governing vessel. The minor extraordinary meridians, the thoroughfare vessel, the girdling vessel, the yin linking vessel, the yin heel vessel, the yang linking vessel, and the yang heel vessel.

[0084] In some embodiments, as shown in FIGS. 4, 10, 12, 13, 16, and 17, the photobiomodulation unit 100 includes six near-infrared light source groups, namely, a first near-infrared light source group 171, a second near-infrared light source group 172, a third near-infrared light source group 173, a fourth near-infrared light source group 174, a fifth near-infrared light source group 175, and a sixth near-infrared light source group 176. Referring not only to FIGS. 4, 16, and 17 but also to FIGS. 10 and 12 in some embodiments, the near-infrared light source groups 171, 172, 173, 174, 175, 176 of the near-infrared light sources 170 present in the photobiomodulation unit 100 are arranged in a rectangular array pattern of three vertical columns and two horizontal rows, and each near-infrared light source group is separated by a vertical column distance d1 and a horizontal row distance d2. In these embodiments, the near-infrared light source groups 171, 172, 173, 174, 175, 176 are arranged in a pattern configured to direct each light source toward a specific region of interest when the photobiomodulation therapy headband 22 is properly placed on the forehead of the person P. For example, in some embodiments, when worn on the forehead of the person P, the photobiomodulation therapy headband 22 is configured such that the first, second, third, fourth, fifth, and sixth near-infrared light source groups 171, 172, 173, 174, 175, 176 are arranged substantially above the supraorbital region 322 so as to be at least above the eye sockets of the person P.In some embodiments, when the photobiomodulation therapy headband 22 is properly worn, the near-infrared light sources 170 of the first near-infrared light source group 171 are arranged at a first position that at least partially overlaps or is substantially centered on the Fp1 site 300, the near-infrared light sources 170 of the second near-infrared light source group 172 are arranged at a second position that at least partially overlaps or is substantially centered on the Fpz site 302, the near-infrared light sources 170 of the third near-infrared light source group 173 are arranged at a third position that at least partially overlaps or is substantially centered on the Fp2 site 304, the near-infrared light sources 170 of the fourth near-infrared light source group 174 are arranged at a fourth position that at least partially overlaps or is substantially centered on the F3 site 306, the near-infrared light sources 170 of the fifth near-infrared light source group 175 are arranged at a fifth position that at least partially overlaps or is substantially centered on the Fz site 308, and the near-infrared light sources 170 of the sixth near-infrared light source group 176 are arranged at a sixth position that at least partially overlaps or is substantially centered on the F4 site 310. Each of the near-infrared light source groups 171, 172, 173, 174, 175, 176 is arranged accordingly.

[0085] In some embodiments, as shown in FIG. 13, the photobiomodulation unit 100 includes six near-infrared light source groups of the near-infrared light source 170, namely, the first near-infrared light source group 171, the second near-infrared light source group 172, the third near-infrared light source group 173, the fourth near-infrared light source group 174, the fifth near-infrared light source group 175, and the sixth near-infrared light source group 176. The six near-infrared light source groups are arranged in two inverted triangles. The first near-infrared light source group 171, the second near-infrared light source group 172, the third near-infrared light source group 173, and the fourth near-infrared light source group 174 are arranged in the upper row, and the fifth near-infrared light source group 175 and the sixth near-infrared light source group 176 are arranged in the lower row. The first near-infrared light source group 171 and the second near-infrared light source group 172 are arranged to cover the region including the sites F3 306 and Fz 308 of the head H, and the third light group 173 and the fourth light group 174 are arranged to cover the region including the sites Fz 308 and F4 310 of the head H. The fifth near-infrared light source group 175 is arranged to cover the region including the site Fp1 300, and the sixth near-infrared light source group 176 is arranged to cover the region including the site Fp2 304. In these embodiments, one or more sensors 180 are arranged between the fifth near-infrared light source group 175 and the sixth near-infrared light source group 176 in the lower row.

[0086] In some embodiments, as shown in FIG. 14, the photobiomodulation unit 100 includes five near-infrared light source groups of near-infrared light sources 170, namely, a first near-infrared light source group 171, a second near-infrared light source group 172, a third near-infrared light source group 173, a fourth near-infrared light source group 174, and a fifth near-infrared light source group 175. The first near-infrared light source group 171, the second near-infrared light source group 172, and the third near-infrared light source group 173 are arranged in the upper horizontal row, and the fourth near-infrared light source group 174 and the fifth near-infrared light source group 175 arranged in the lower horizontal row, the fourth near-infrared light source group 174 is disposed below the first near-infrared light source group 171, and the fifth near-infrared light source group 175 is disposed below the third near-infrared light source group 173. The first near-infrared light source group 171, the second near-infrared light source group 172, and the third near-infrared light source group 173 are arranged to cover the region including the sites F3 306, Fz 308, and F4 310 of the head H. The fourth near-infrared light source group 174 is arranged to cover the region including the site Fp1 300, and the fifth near-infrared light source group 175 is arranged to cover the region including the site Fp2 304. In these embodiments, one or more sensors 180 are arranged in the lower horizontal row, below the second near-infrared light source group 172 and between the fourth near-infrared light source group 174 and the fifth near-infrared light source group 175.

[0087] In some embodiments, as shown in FIG. 15, the photobiomodulation unit 100 includes three near-infrared light source groups of near-infrared light sources 170, namely, a first near-infrared light source group 171, a second near-infrared light source group 172, and a third near-infrared light source group 173. The first near-infrared light source group 171, the second near-infrared light source group 172, and the third near-infrared light source group 173 are arranged in a horizontal row and are arranged to cover the region including the sites F3 306, Fz 308, and F4 310 of the head H. In these embodiments, one or more sensors 180 are arranged below the second near-infrared light source group 172.

[0088] In some embodiments, as shown in FIG. 21, the photobiomodulation unit 100 includes two near-infrared light source intergroups of the near-infrared light source 170, and each intergroup includes four near-infrared light sources 170 arranged in a 2×2 pattern. The first intergroup is substantially centered on sites Fp1 300 and F3 306 and at least partially overlaps Fpz 302 and Fz 308, and the second intergroup is substantially centered on sites Fp2 304 and F4 310 and at least partially overlaps Fpz 302 and Fz 308. In these embodiments, one or more sensors 180 are disposed between the first near-infrared light source group and the second near-infrared light source group. In aspects of these embodiments, the photobiomodulation unit 100 includes two stimulation devices 194, one of the stimulation devices 194 being disposed substantially centrally within the first infrared light source intergroup and the other stimulation device 194 being disposed substantially centrally within the second infrared light source intergroup. In aspects of these embodiments, the stimulation device 194 is a transcranial direct current stimulation device.

[0089] In some embodiments, as shown in FIG. 25, the photobiomodulation unit 100 includes four near-infrared light source inter-groups of near-infrared light sources 170, and each inter-group includes five near-infrared light sources 170 arranged in three columns and two columns. The first inter-group and the second inter-group are substantially centered on sites Fp1 300 and F3 306, and at least partially overlap Fpz 302 and Fz 308. The third inter-group and the fourth inter-group are substantially centered on sites Fp2 304 and F4 310, and at least partially overlap Fpz 302 and Fz 308. In these embodiments, one or more sensors 180 are arranged between the first and second near-infrared light source groups and the third and fourth near-infrared light source groups. In aspects of these embodiments, the photobiomodulation unit 100 includes two stimulation devices 194, one stimulation device 194 being arranged substantially centrally between the first and second infrared light source inter-groups, and the other stimulation device 194 being arranged substantially centrally between the third and fourth infrared light source inter-groups. In aspects of these embodiments, the stimulation device 194 is a transcranial direct current stimulation device.

[0090] In some embodiments, as shown in FIGS. 12-17, 21, and 25, each of the near-infrared light source groups includes a single-light near-infrared light source 170. For example, as shown in FIGS. 12-15 and 17, each of the near-infrared light source groups 171, 172, 173, 174, 175, 176 of the photobiomodulation unit 100 includes a single-light near-infrared light source 170. In embodiments where only single-light near-infrared light sources 170 are present in the near-infrared light source groups, such near-infrared light sources 170 are preferably high-output near-infrared light sources having a radiation intensity (luminance) range of about 150 mW / sr or more, more preferably about 250 mW / sr or more.

[0091] In some embodiments, each of the near-infrared light source groups includes a plurality of near-infrared light sources 170. For example, as shown in FIGS. 10 and 16, each of the near-infrared light source groups 171, 172, 173, 174, 175, 176 of the photobiomodulation unit 100 includes nine near-infrared light sources 170. In embodiments where the near-infrared light source group has a plurality of near-infrared light sources 170, all such near-infrared light sources 170 can be low-output near-infrared light sources having a radiation intensity (luminance) range of 125 mW / sr or less. In other embodiments where the near-infrared light source group has a plurality of near-infrared light sources 170, all such near-infrared light sources 170 can be a combination of both high-output near-infrared light sources having a radiation intensity (luminance) range of about 150 mW / sr or more, more preferably about 250 mW / sr or more, and low-output near-infrared light sources having a radiation intensity (luminance) range of 125 mW / sr or less.

[0092] Furthermore, in embodiments where the near-infrared light source group includes a plurality of near-infrared light sources 170, there is an intra-group spacing between each adjacent near-infrared light source 170 within the same group as each individual near-infrared light source 170. The intra-group spacing of each near-infrared light source 170 in the near-infrared light intra-group can be the same between each individual near-infrared light source 170, or can be varied according to a desired dose measurement value and according to the relative position of the desired region of interest. In some embodiments, each individual near-infrared light source 170 of each of the near-infrared light source groups is arranged in a pattern configured for a desired therapeutic effect where each individual near-infrared light source 170 is random with respect to other individual near-infrared light sources within the same near-infrared light source group, and / or in a pattern determined by a combination of factors including a desired therapeutic effect, cost, and manufacturing capabilities. The relative pattern of the near-infrared light source groups is configured such that each near-infrared light source 170 is arranged on the photobiomodulation therapy garment 20 so as to at least partially cover each respective region of interest on the skin surface S, which may appear to be a random pattern to an observer not of interest.

[0093] Each individual near-infrared light source 170 within the near-infrared light intra-group is separated from all other individual near-infrared light sources 170 within the same intra-group by an intra-group light source interval. Each near-infrared light source 170 of the near-infrared light intra-group can be arranged in a pattern that matches the positions of a plurality of regions of interest on the skin surface S. Thus, the resulting near-infrared light intra-group can ostensibly be arranged in an irregular pattern corresponding to the positions of the plurality of regions of interest on the skin surface S, in which case each region of interest can be at least partially covered simultaneously by the corresponding group. As a result, the inter-group interval and relative arrangement of each near-infrared light source 170 of the near-infrared light intra-group can be varied according to the positions of the regions of interest on the skin surface S.

[0094] In some embodiments, in a rectangular arrangement such as that shown in FIG. 4 for example, the spacing between each of the near-infrared light intra-group near-infrared light sources 170 can be defined by the column spacing d3 and the row spacing d4. The intra-group spacing can be measured from the center of the near-infrared light source 170. In some embodiments, the column spacing d3 and the row spacing d4 are at least 2 mm, at least 3 mm, at least 4 mm, at least 5 mm, at least 6 mm, at least 7 mm, at least 8 mm, at least 9 mm, at least 10 mm, at least 12 mm, or at least 15 mm. In a rectangular array, the row spacing d3 can be the same distance as the column spacing d4 or can be different from the column spacing d4. In such a rectangular arrangement, each of the near-infrared light intra-group near-infrared light sources 170 is arranged in an n1×n2 array, where n1 and n2 each represent the number of individual near-infrared light sources 170 in each of the rows and columns respectively. For example, the infrared light intra-group can be a 2×2 array, a 2×3 array, a 3×2 array, a 3×3 array, a 3×4 array, a 4×3 array, a 4×4 array, a 2×5 array, a 5×2 array, a 3×5 array, a 5×3 array, a 4×5 array, a 5×4 array, and a 5×5 array, etc. In some embodiments, each of the near-infrared light intra-group near-infrared light sources 170 can be configured as a radial or circular array around a single circle or a plurality of concentric circles. In these embodiments, the inter-group spacing can be measured from the center of the light source.

[0095] In some embodiments, each of the near-infrared light sources of the photobiomodulation therapy clothing 20 is configured as a near-infrared light intra-group including a plurality of near-infrared light sources 170 arranged in an intra-group arrangement. In some embodiments, the near-infrared light source groups 171, 172, 173, 174, 175, 176 of the photobiomodulation therapy clothing 20 are each configured as a near-infrared light intra-group including a plurality of near-infrared light sources 170 arranged in an intra-group arrangement. The first near-infrared light source group 171 includes a plurality of near-infrared light sources 170 arranged in the first near-infrared light intra-group. The second near-infrared light source group 172 includes a plurality of near-infrared light sources 170 arranged in the second near-infrared light intra-group. The third near-infrared light source group 173 includes a plurality of near-infrared light sources 170 arranged in the third near-infrared light intra-group. The fourth near-infrared light source group 174 includes a plurality of near-infrared light sources 170 arranged in the fourth near-infrared light intra-group. The fifth near-infrared light source group 175 includes a plurality of near-infrared light sources 170 arranged in the fifth near-infrared light intra-group. The sixth near-infrared light source group 176 includes a plurality of near-infrared light sources 170 arranged in the sixth near-infrared light intra-group.

[0096] In some embodiments, referring to FIGS. 4, 10, and 13, the near-infrared light source groups 171, 172, 173, 174, 175, 176 of the photobiomodulation therapy headband 22 are each configured as a near-infrared light intra-group including nine near-infrared light sources 170 arranged in a 3×3 array of three vertical rows and three horizontal rows. In this example, d3 is greater than d4, which can provide therapeutic advantages due to the combination and overlap of the light patterns incident on the surface of the skin surface S, as well as strategic gaps or regions with less overlap of the light patterns. In the illustrated exemplary embodiment, d3 = 6 mm to 7 mm and d4 = 9 mm to 10 mm. The overlapping pattern of the incident light results in regions of various output levels incident on the skin surface S within and around each array or group, including the region of maximum irradiance and fluence directly under each individual near-infrared light source 170, the region of smaller irradiance and fluence between adjacent individual near-infrared light sources 170, and the region of minimum irradiance and fluence between the individual near-infrared light sources 170 located farthest from each other. Further, each near-infrared light intra-group of the near-infrared light source groups 171, 172, 173, 174, 175, 176 is shown as having the same intra-group pattern, but the intra-group pattern can be composed of different patterns and numbers of individual near-infrared light sources 170, which can be determined based on the desired form of therapy and the dosimetry required for each region of interest.

[0097] In one or more embodiments, during operation, all of the groups of near-infrared light sources can be actuated by the controller 200 using the same operating parameters (e.g., all groups are in pulse mode and are actuated simultaneously with the same output settings). In one or more embodiments, during operation, each of the groups of near-infrared light sources can be actuated by the controller 200 using different operating parameters, and one or more selected groups can be actuated with the other groups turned off. Further, in one or more embodiments, the controller 200 has the ability to control the output level and / or pulse / continuous operation for each group of near-infrared light sources, independent of the other groups of near-infrared light sources of the photobiomodulation therapy garment 20. There is great flexibility in the available operating parameters. Not only can each individual group of near-infrared light be actuated individually, but each individual near-infrared light source 170 within each group of near-infrared light can be individually specified and controlled using individual operating parameters. In this way, each individual near-infrared light source 170 can be individually specified as a unit so that each can operate / turn on or stop / turn off independently of all the other individual near-infrared light sources 170. Further, in one or more embodiments, each individual near-infrared light source 170 can be operated in pulse mode or continuous mode independently of all the other individual near-infrared light sources 170. Further, in one or more embodiments, each individual near-infrared light source 170 can be operated using an output profile independent of all the other individual light sources. In this way, several predetermined patterns can be initiated by executable instructions from the controller 200, and the pattern of actuated light sources can be changed according to the desired therapeutic effect and the location of the area of interest.

[0098] Referring now to FIGS. 9, 16, 17, 20, and 24, in some embodiments, the photobiomodulation therapy garment 20 is assembled by sandwiching a photobiomodulation unit 100 between an outer fabric sheet 40 and an inner fabric sheet 70. In some embodiments, as shown in FIGS. 9, 20, and 24, a hot melt adhesive film 240 sized and shaped to cover a substantial portion or all of the flexible printed circuit board assembly 110 but not the terminal rail mount 164 of the connection terminal 160 is disposed between the outer fabric sheet 40 and the photobiomodulation unit 100. In some embodiments, as shown in FIGS. 16 and 17, the liquid wire circuit assembly 150 is directly attached to the outer fabric sheet 40, such as by using an adhesive or by knitting it into the outer fabric sheet 40. In embodiments where the photobiomodulation unit 100 includes a flexible printed circuit board assembly 110, the photobiomodulation unit 100 is aligned with the outer fabric sheet 40 such that the terminal rail mount 164 of the connection terminal 160 can be inserted through the terminal rail mount opening 58. In embodiments where the photobiomodulation unit 100 includes a liquid wire circuit assembly 150, the connection terminal 160 is attached to the outer fabric sheet 40 while the liquid wire circuit assembly 150 is being fabricated on the outer fabric sheet 40.

[0099] Referring further to FIGS. 9, 16, 17, 20, and 24, when the photobiomodulation unit 100 is disposed on the outer cloth sheet 40, a layer of double-sided tape 250 sized and shaped to cover a substantial portion or all of the photobiomodulation unit 100 is disposed between the photobiomodulation unit 100 and the inner cloth sheet 70. The double-sided tape 250 includes one or more near-infrared light source openings 252 and one or more sensor openings 254, which are cutouts configured to provide gaps for their respective components so that the double-sided tape 250 does not interfere with the operation of the one or more near-infrared light sources 170 and the one or more sensors 180. If present, the sensor cover 79 is appropriately positioned to cover its corresponding sensor 180. Next, the inner cloth sheet 70 is aligned with the outer cloth sheet 40 and the photobiomodulation unit 100, and each of the one or more near-infrared light sources 170 and each of the one or more sensors 180 are appropriately positioned relative to their corresponding near-infrared light source openings 76 and sensor openings 78 such that proper functioning of these components is enabled. Next, the inner cloth sheet 70 can be secured to the outer cloth sheet 40 by sewing the edge of the inner cloth sheet 70 to the outer cloth sheet 40.

[0100] In some embodiments, as shown in FIGS. 20 and 24, the photobiomodulation unit 100 can optionally comprise a frame 260, a gel 270, a heat dissipating material 280, or any combination thereof. The frame 260 provides structural support and protection to the one or more near-infrared light sources 170, the one or more sensors 180, and the one or more stimulation devices 194. The gel 270 functions as a pad to provide comfort to the user when the photobiomodulation therapy clothing disclosed herein is worn. The heat dissipating material 280 functions to dissipate heat generated by the one or more near-infrared light sources 170, the one or more sensors 180, and the one or more stimulation devices 194 during operation of the photobiomodulation therapy clothing disclosed herein.

[0101] The clothing for photobiomodulation therapy disclosed herein is useful for providing photobiomodulation therapy. In some embodiments, the photobiomodulation therapy is transcranial photobiomodulation therapy. Such non-invasive light-based neuromodulation therapy does not require medication and provides long-term benefits by changing the way the user's brain functions at the neuronal level by providing various positive photochemical reactions. For example, photobiomodulation therapy can increase neuronal mitochondrial energy and adenosine triphosphate (ATP) production by enhancing cytochrome c oxidase activity, and as a result, increase cellular energy production. In addition, the transmission of light energy can also suppress inflammation at the cellular and tissue levels, produce reactive oxygen species (ROS) that can improve cell repair and healing, and induce nitric oxide (NO) production important for good vascular health and optimal blood flow, nutrient delivery, and waste excretion. This is important because insufficient cerebral blood flow and blood circulation can cause the brain to have vague memory, forgetfulness, decreased concentration, and even dementia. The enhancement of cellular energy and the increase in cerebral blood flow result in increased neurogenesis and neuroplasticity, increased neuroprotection, enhanced nerve repair, and reduced inflammation. In addition, such photobiomodulation therapy provides both sedative and relaxation benefits, as well as improved concentration and performance, resulting in improved mental productivity, mental health, and overall cognitive function.

[0102] This specification discloses a method for improving an individual's cerebral blood flow using photobiomodulation therapy, the method comprising exposing a head region to infrared light from the clothing for photobiomodulation therapy disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include the frontal region, the temporal region, the occipital region, or any combination thereof.

[0103] In some embodiments, the disclosed method for improving cerebral blood flow is, for example, about 10 cm2 ~ about 15 cm 2 、 about 10 cm 2 ~ about 20 cm 2 、 about 10 cm 2 ~ about 25 cm 2 、 about 10 cm 2 ~ about 30 cm 2 、 about 10 cm 2 ~ about 35 cm 2 、 about 10 cm 2 ~ about 40 cm 2 、 about 10 cm 2 ~ about 45 cm 2 、 about 10 cm 2 ~ about 50 cm 2 、 about 15 cm 2 ~ about 20 cm 2 、 about 15 cm 2 ~ about 25 cm 2 、 about 15 cm 2 ~ about 30 cm 2 、 about 15 cm 2 ~ about 35 cm 2 、 about 15 cm 2 ~ about 40 cm 2 、 about 15 cm 2 ~ about 45 cm 2 、 about 15 cm 2 ~ about 50 cm 2 、 about 20 cm 2 ~ about 25 cm 2 、 about 20 cm 2 ~ about 30 cm 2 、 about 20 cm 2 ~ about 35 cm 2 、 about 20 cm 2 ~ about 40 cm 2 、 about 20 cm 2 ~ about 45 cm 2 、 about 20 cm 2 ~ about 50 cm 2、 about 25 cm 2 ~ about 30 cm 2 、 about 25 cm 2 ~ about 35 cm 2 、 about 25 cm 2 ~ about 40 cm 2 、 about 25 cm 2 ~ about 45 cm 2 、 about 25 cm 2 ~ about 50 cm 2 、 about 30 cm 2~about 35 cm 2 、about 30 cm 2 ~about 40 cm 2 、about 30 cm 2 ~about 45 cm 2 、or about 30 cm 2 ~about 50 cm 2 including exposing a head region that includes an area of

[0104] In some embodiments, the disclosed method of improving cerebral blood flow can include a single treatment session or multiple treatment sessions. In aspects of these embodiments, the disclosed method of improving cerebral blood flow can include, for example, about 1 to about 5 treatment sessions, about 1 to about 10 treatment sessions, about 1 to about 15 treatment sessions, about 1 to about 20 treatment sessions, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions. In other aspects of these embodiments, the disclosed method of improving cerebral blood flow can include multiple treatment sessions that continue for several months or years.

[0105] In some embodiments, the disclosed method of improving cerebral blood flow includes exposing the head region to infrared light during a treatment session for, for example, about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes.

[0106] In some embodiments, the disclosed method of improving cerebral blood flow is, for example, about 50 mW / cm 2 ~about 100 mW / cm 2 、about 50 mW / cm2 ~ about 150 mW / cm 2 , about 50 mW / cm 2 ~ about 200 mW / cm 2 , about 50 mW / cm 2 ~ about 250 mW / cm 2 , about 50 mW / cm 2 ~ about 300 mW / cm 2 , about 100 mW / cm 2 ~ about 150 mW / cm 2 , about 100 mW / cm 2 ~ about 200 mW / cm 2 , about 100 mW / cm 2 ~ about 250 mW / cm 2 , about 100 mW / cm 2 ~ about 300 mW / cm 2 , about 150 mW / cm 2 ~ about 200 mW / cm 2 , about 150 mW / cm 2 ~ about 250 mW / cm 2 , about 150 mW / cm 2 ~ about 300 mW / cm 2 , about 200 mW / cm 2 ~ about 250 mW / cm 2 , about 200 mW / cm 2 ~ about 300 mW / cm 2 , or about 250 mW / cm 2 ~ about 300 mW / cm 2 includes infrared light including an average irradiance region of about 250 mW / cm to about 300 mW / cm.

[0107] In some embodiments, the disclosed method for improving cerebral blood flow is, for example, about 30 J / cm 2 ~ about 50 J / cm 2 , about 30 J / cm 2 ~ about 75 J / cm 2 , about 30 J / cm 2 ~ about 100 J / cm 2 , about 30 J / cm 2 ~ about 125 J / cm 2 , about 30 J / cm 2 ~ about 150 J / cm 2 , about 50 J / cm 2 ~ about 75 J / cm 2 , about 50 J / cm 2~ about 100 J / cm 2 、 about 50 J / cm 2 ~ about 125 J / cm 2 、 about 50 J / cm 2 ~ about 150 J / cm 2 、 about 75 J / cm 2 ~ about 100 J / cm 2 、 about 75 J / cm 2 ~ about 125 J / cm 2 、 about 75 J / cm 2 ~ about 150 J / cm 2 、 about 100 J / cm 2 ~ about 125 J / cm 2 、 about 100 J / cm 2 ~ about 150 J / cm 2 、 or about 100 J / cm 2 ~ about 150 J / cm 2 includes infrared light including an average fluence over a body region of

[0108] In some embodiments, the disclosed method of improving cerebral blood flow involves infrared light having a total incident energy during a treatment session of, for example, from about 0.5 kJ to about 1.0 kJ, from about 0.5 kJ to about 1.5 kJ, from about 0.5 kJ to about 2.0 kJ, from about 0.5 kJ to about 2.5 kJ, from about 0.5 kJ to about 3.0 kJ, from about 0.5 kJ to about 3.5 kJ, from about 0.5 kJ to about 4.0 kJ, from about 0.5 kJ to about 4.5 kJ, from about 0.5 kJ to about 5.0 kJ, from about 0.5 kJ to about 5.5 kJ, from about 0.5 kJ to about 6 kJ, from about 1.0 kJ to about 1.5 kJ, from about 1.0 kJ to about 2.0 kJ, from about 1.0 kJ to about 2.5 kJ, from about 1.0 kJ to about 3.0 kJ, from about 1.0 kJ to about 3.5 kJ, from about 1.0 kJ to about 4.0 kJ, from about 1.0 kJ to about 4.5 kJ, from about 1.0 kJ to about 5.0 kJ, from about 1.0 kJ to about 5.5 kJ, from about 1.0 kJ to about 6 kJ, from about 1.5 kJ to about 2.0 kJ, from about 1.5 kJ to about 2.5 kJ, from about 1.5 kJ to about 3.0 kJ, from about 1.5 kJ to about 3.5 kJ, from about 1.5 kJ to about 4.0 kJ, from about 1.5 kJ to about 4.5 kJ, from about 1.5 kJ to about 5.0 kJ, from about 1.5 kJ to about 5.5 kJ, from about 1.5 kJ to about 6 kJ, from about 2.0 kJ to about 2.5 kJ, from about 2.0 kJ to about 3.0 kJ, from about 2.0 kJ to about 3.5 kJ, from about 2.0 kJ to about 4.0 kJ, from about 2.0 kJ to about 4.5 kJ, from about 2.0 kJ to about 5.0 kJ, from about 2.0 kJ to about 5.5 kJ, from about 2.0 kJ to about 6 kJ, from about 2.5 kJ to about 3.0 kJ, from about 2.5 kJ to about 3.5 kJ, from about 2.5 kJ to about 4.0 kJ, from about 2.5 kJ to about 4.5 kJ, from about 2.5 kJ to about 5.0 kJ, from about 2.5 kJ to about 5.5 kJ, from about 2.5 kJ to about 6 kJ, from about 3.0 kJ to about 3.5 kJ, from about 3.0 kJ to about 4.0 kJ, from about 3.0 kJ to about 4.5 kJ, from about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0109] In some embodiments, the disclosed method of improving cerebral blood flow includes infrared light having a total output over a body area of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5,000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about 6,000 mW, about 5,000 mW to about 7,000 mW, about 5,000 mW to about 8,000 mW, about 5,000 mW to about 9,000 mW, about 6,000 mW to about 7,000 mW, about 6,000 mW to about 8,000 mW, about 6,000 mW to about 9,000 mW, about 7,000 mW to about 8,000 mW, about 7,000 mW to about 9,000 mW, or about 8,000 mW to about 9,000 mW.

[0110] In aspects of these embodiments, the disclosed method of improving cerebral blood flow includes exposing a head region that includes an area of about 18 cm 2 to about 27 cm 2 . In other aspects of these embodiments, the disclosed method of improving cerebral blood flow includes an average irradiance region of about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence over the head region of about 30 J / cm 2 to about 150 J / cm 2It includes infrared light that is such, that the total incident energy during the treatment session is from about 0.5 kJ to about 6 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method of improving cerebral blood flow includes infrared light that includes a total output across the head region from about 900 mW to about 8,100 mW. In still other aspects of these embodiments, the disclosed method of improving cerebral blood flow further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy clothing disclosed herein.

[0111] In aspects of these embodiments, the disclosed method of improving cerebral blood flow includes exposing a head region that includes an area of from about 20 cm 2 to about 28 cm 2 . In other aspects of these embodiments, the disclosed method of improving cerebral blood flow includes an average irradiance region of from about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region of from about 30 J / cm 2 to about 150 J / cm 2It includes infrared light that has the following characteristics: the total incident energy during the treatment session is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method for improving cerebral blood flow includes infrared light having a total output across the head region of about 1,000 mW to about 8,400 mW. In yet other aspects of these embodiments, the disclosed method for improving cerebral blood flow further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method for improving cerebral blood flow can include a single treatment session or multiple treatment sessions, such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0112] In aspects of these embodiments, the disclosed method for improving cerebral blood flow includes exposing a head region that includes an area of about 22 cm 2 to about 26 cm 2 . In other aspects of these embodiments, the disclosed method for improving cerebral blood flow includes an average irradiance region of about 250 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region of about 150 J / cm 2 to about 200 J / cm 2including infrared light such that the total incident energy during a treatment session is about 4 kJ to about 5 kJ, or any combination thereof. In yet other aspects of these embodiments, the disclosed method for improving cerebral blood flow includes infrared light having a total output across the head region of about 3,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method for improving cerebral blood flow further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method for improving cerebral blood flow can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0113] This specification discloses that a method for treating a person's depression using photobiomodulation therapy includes exposing a head region to infrared light from the headgear for photobiomodulation therapy disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include the frontal region, the temporal region, the occipital region, or any combination thereof.

[0114] In some embodiments, the disclosed method for treating depression is, for example, about 10 cm 2 to about 15 cm 2 about 10 cm 2 to about 20 cm 2 about 10 cm 2 to about 25 cm 2 about 10 cm 2 to about 30 cm 2 about 10 cm 2 to about 35 cm 2 about 10 cm 2 to about 40 cm2 、about 10 cm 2 ~ about 45 cm 2 、about 10 cm 2 ~ about 50 cm 2 、about 15 cm 2 ~ about 20 cm 2 、about 15 cm 2 ~ about 25 cm 2 、about 15 cm 2 ~ about 30 cm 2 、about 15 cm 2 ~ about 35 cm 2 、about 15 cm 2 ~ about 40 cm 2 、about 15 cm 2 ~ about 45 cm 2 、about 15 cm 2 ~ about 50 cm 2 、about 20 cm 2 ~ about 25 cm 2 、about 20 cm 2 ~ about 30 cm 2 、about 20 cm 2 ~ about 35 cm 2 、about 20 cm 2 ~ about 40 cm 2 、about 20 cm 2 ~ about 45 cm 2 、about 20 cm 2 ~ about 50 cm 2、 about 25 cm 2 ~ about 30 cm 2 、about 25 cm 2 ~ about 35 cm 2 、about 25 cm 2 ~ about 40 cm 2 、about 25 cm 2 ~ about 45 cm 2 、about 25 cm 2 ~ about 50 cm 2 、about 30 cm 2 ~ about 35 cm 2 、about 30 cm 2 ~ about 40 cm 2 、about 30 cm 2 ~ about 45 cm 2 、or about 30 cm 2 ~ about 50 cm 2 including exposing a head region including an area of about 30 cm to about 50 cm.

[0115] In some embodiments, the disclosed methods for treating depression can include a single treatment session or multiple treatment sessions. In aspects of these embodiments, the disclosed methods for treating depression can include, for example, about 1 to about 5 treatment sessions, about 1 to about 10 treatment sessions, about 1 to about 15 treatment sessions, about 1 to about 20 treatment sessions, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions. In other aspects of these embodiments, the disclosed methods for treating depression can include multiple treatment sessions that continue for several months or years.

[0116] In some embodiments, the disclosed methods for treating depression include exposing the head region to infrared light for, for example, between about 5 minutes and about 10 minutes, about 5 minutes and about 15 minutes, about 5 minutes and about 20 minutes, about 5 minutes and about 25 minutes, about 5 minutes and about 30 minutes, about 5 minutes and about 35 minutes, about 5 minutes and about 40 minutes, about 10 minutes and about 15 minutes, about 10 minutes and about 20 minutes, about 10 minutes and about 25 minutes, about 10 minutes and about 30 minutes, about 10 minutes and about 35 minutes, about 10 minutes and about 40 minutes, about 15 minutes and about 20 minutes, about 15 minutes and about 25 minutes, about 15 minutes and about 30 minutes, about 15 minutes and about 35 minutes, or about 15 minutes and about 40 minutes during a treatment session.

[0117] In some embodiments, the disclosed methods for treating depression are, for example, about 50 mW / cm 2 ~ about 100 mW / cm 2 、 about 50 mW / cm 2 ~ about 150 mW / cm 2 、 about 50 mW / cm 2 ~ about 200 mW / cm 2 、 about 50 mW / cm 2 ~ about 250 mW / cm 2 、 about 50 mW / cm 2 ~ about 300 mW / cm 2 、 about 100 mW / cm 2~about 150 mW / cm 2 、about 100 mW / cm 2 ~about 200 mW / cm 2 、about 100 mW / cm 2 ~about 250 mW / cm 2 、about 100 mW / cm 2 ~about 300 mW / cm 2 、about 150 mW / cm 2 ~about 200 mW / cm 2 、about 150 mW / cm 2 ~about 250 mW / cm 2 、about 150 mW / cm 2 ~about 300 mW / cm 2 、about 200 mW / cm 2 ~about 250 mW / cm 2 、about 200 mW / cm 2 ~about 300 mW / cm 2 、or about 250 mW / cm 2 ~about 300 mW / cm 2 includes infrared light including an average irradiance region of.

[0118] In some embodiments, the disclosed method for treating depression is, for example, about 30 J / cm 2 ~about 50 J / cm 2 、about 30 J / cm 2 ~about 75 J / cm 2 、about 30 J / cm 2 ~about 100 J / cm 2 、about 30 J / cm 2 ~about 125 J / cm 2 、about 30 J / cm 2 ~about 150 J / cm 2 、about 50 J / cm 2 ~about 75 J / cm 2 、about 50 J / cm 2 ~about 100 J / cm 2 、about 50 J / cm 2 ~about 125 J / cm 2 、about 50 J / cm 2 ~about 150 J / cm 2 、about 75 J / cm 2 ~about 100 J / cm 2 、about 75 J / cm 2 ~about 125 J / cm 2, about 75 J / cm 2 ~ about 150 J / cm 2 , about 100 J / cm 2 ~ about 125 J / cm 2 , about 100 J / cm 2 ~ about 150 J / cm 2 , or about 100 J / cm 2 ~ about 150 J / cm 2 including infrared light with an average fluence over a body region of about 100 J / cm to about 150 J / cm, or about 100 J / cm to about 150 J / cm.

[0119] In some embodiments, the disclosed method for treating depression includes infrared light having a total incident energy during a treatment session of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2.5 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, about 3.0 kJ to about 5.0 kJ, about 3.0 kJ to about 5.5 kJ, about 3.0 kJ to about 6 kJ, about 3.5 kJ to about 4.0 kJ, about 3.5 kJ to about 4.5 kJ, about 3.5 kJ to about 5.0 kJ, about 3.5 kJ to about 5.5 kJ, about 3.5 kJ to about 6 kJ, about 4.0 kJ to about 4.5 kJ, about 4.0 kJ to about 5.0 kJ, about 4.0 kJ to about 5.5 kJ, about 4.0 kJ to about 6 kJ, about 4.5 kJ to about 5.0 kJ, about 4.5 kJ to about 5.5 kJ, about 4.5 kJ to about 6 kJ, about 5.0 kJ to about 5.5 kJ, about 5.0 kJ to about 6 kJ, or about 5.5 kJ to about 6 kJ.

[0120] In some embodiments, the disclosed method of treating depression includes infrared light having a total output over a body area of, for example, from about 1,000 mW to about 2,000 mW, from about 1,000 mW to about 3,000 mW, from about 1,000 mW to about 4,000 mW, from about 1,000 mW to about 5,000 mW, from about 1,000 mW to about 6,000 mW, from about 1,000 mW to about 7,000 mW, from about 1,000 mW to about 8,000 mW, from about 1,000 mW to about 9,000 mW, from about 2,000 mW to about 3,000 mW, from about 2,000 mW to about 4,000 mW, from about 2,000 mW to about 5,000 mW, from about 2,000 mW to about 6,000 mW, from about 2,000 mW to about 7,000 mW, from about 2,000 mW to about 8,000 mW, from about 2,000 mW to about 9,000 mW, from about 3,000 mW to about 4,000 mW, from about 3,000 mW to about 5,000 mW, from about 3,000 mW to about 6,000 mW, from about 3,000 mW to about 7,000 mW, from about 3,000 mW to about 8,000 mW, from about 3,000 mW to about 9,000 mW, from about 4,000 mW to about 5,000 mW, from about 4,000 mW to about 6,000 mW, from about 4,000 mW to about 7,000 mW, from about 4,000 mW to about 8,000 mW, from about 4,000 mW to about 9,000 mW, from about 5,000 mW to about 6,000 mW, from about 5,000 mW to about 7,000 mW, from about 5,000 mW to about 8,000 mW, from about 5,000 mW to about 9,000 mW, from about 6,000 mW to about 7,000 mW, from about 6,000 mW to about 8,000 mW, from about 6,000 mW to about 9,000 mW, from about 7,000 mW to about 8,000 mW, from about 7,000 mW to about 9,000 mW, or from about 8,000 mW to about 9,000 mW.

[0121] In aspects of these embodiments, the disclosed method of treating depression includes exposing a head region that includes an area of from about 18 cm 2 to about 27 cm 2 . In other aspects of these embodiments, the disclosed method of treating depression includes an average irradiance region of from about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the head region of from about 30 J / cm 2 to about 150 J / cm 2It includes infrared light that meets the following conditions: the total incident energy during the treatment session is about 0.5 kJ to about 6 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method for treating depression includes infrared light with a total output across the head region of about 900 mW to about 8,100 mW. In yet other aspects of these embodiments, the disclosed method for treating depression further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be performed using the clothing for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method for treating depression can include a single treatment session or multiple treatment sessions, such as about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0122] In aspects of these embodiments, the disclosed method for treating depression includes exposing a head region that includes an area of about 20 cm 2 to about 28 cm 2 . In other aspects of these embodiments, the disclosed method for treating depression includes an average irradiance region of about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region of about 30 J / cm 2 to about 150 J / cm 2including infrared light such that the total incident energy during a treatment session is from about 1.5 kJ to about 3.5 kJ, or any combination thereof. In yet other aspects of these embodiments, the disclosed method of treating depression includes infrared light having a total output across the head region from about 1,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method of treating depression further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method of treating depression can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0123] In aspects of these embodiments, the disclosed method of treating depression includes exposing a head region that includes an area from about 22 cm 2 to about 26 cm 2 . In other aspects of these embodiments, the disclosed method of treating depression includes an average irradiance region from about 250 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region from about 150 J / cm 2 to about 200 J / cm 2It includes infrared light that is such, that the total incident energy during the treatment session is about 4 kJ to about 5 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method for treating depression includes infrared light having a total output across the head region of about 3,000 mW to about 8,400 mW. In yet other aspects of these embodiments, the disclosed method for treating depression further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method for treating depression can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0124] This specification discloses that a method for treating an individual's autistic disorder using photobiomodulation therapy includes exposing the head region to infrared light from the headgear for photobiomodulation therapy disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include the frontal region, the temporal region, the occipital region, or any combination thereof.

[0125] In some embodiments, the disclosed method for treating autistic disorder is, for example, about 10 cm 2 ~ about 15 cm 2 、about 10 cm 2 ~ about 20 cm 2 、about 10 cm 2 ~ about 25 cm 2 、about 10 cm 2 ~ about 30 cm 2 、about 10 cm 2 ~ about 35 cm 2 、about 10 cm 2~about 40 cm 2 、about 10 cm 2 ~about 45 cm 2 、about 10 cm 2 ~about 50 cm 2 、about 15 cm 2 ~about 20 cm 2 、about 15 cm 2 ~about 25 cm 2 、about 15 cm 2 ~about 30 cm 2 、about 15 cm 2 ~about 35 cm 2 、about 15 cm 2 ~about 40 cm 2 、about 15 cm 2 ~about 45 cm 2 、about 15 cm 2 ~about 50 cm 2 、about 20 cm 2 ~about 25 cm 2 、about 20 cm 2 ~about 30 cm 2 、about 20 cm 2 ~about 35 cm 2 、about 20 cm 2 ~about 40 cm 2 、about 20 cm 2 ~about 45 cm 2 、about 20 cm 2 ~about 50 cm 2、 about 25 cm 2 ~about 30 cm 2 、about 25 cm 2 ~about 35 cm 2 、about 25 cm 2 ~about 40 cm 2 、about 25 cm 2 ~about 45 cm 2 、about 25 cm 2 ~about 50 cm 2 、about 30 cm 2 ~about 35 cm 2 、about 30 cm 2 ~about 40 cm 2 、about 30 cm 2 ~about 45 cm 2 、or about 30 cm 2 ~about 50 cm 2 including exposing a head region including an area of about 30 cm to about 50 cm.

[0126] In some embodiments, the disclosed method of treating an autistic disorder can include a single treatment session or multiple treatment sessions. In aspects of these embodiments, the disclosed method of treating an autistic disorder can include, for example, about 1 to about 5 treatment sessions, about 1 to about 10 treatment sessions, about 1 to about 15 treatment sessions, about 1 to about 20 treatment sessions, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions. In other aspects of these embodiments, the disclosed method of treating an autistic disorder can include multiple treatment sessions that continue for several months or years.

[0127] In some embodiments, the disclosed method of treating an autistic disorder includes exposing the head region to infrared light during a treatment session, for example, for a period of about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes.

[0128] In some embodiments, the disclosed method of treating an autistic disorder is, for example, about 50 mW / cm 2 ~ about 100 mW / cm 2 、 about 50 mW / cm 2 ~ about 150 mW / cm 2 、 about 50 mW / cm 2 ~ about 200 mW / cm 2 、 about 50 mW / cm 2 ~ about 250 mW / cm 2 、 about 50 mW / cm 2 ~ about 300 mW / cm 2 、 about 100 mW / cm2 ~ about 150 mW / cm 2 , about 100 mW / cm 2 ~ about 200 mW / cm 2 , about 100 mW / cm 2 ~ about 250 mW / cm 2 , about 100 mW / cm 2 ~ about 300 mW / cm 2 , about 150 mW / cm 2 ~ about 200 mW / cm 2 , about 150 mW / cm 2 ~ about 250 mW / cm 2 , about 150 mW / cm 2 ~ about 300 mW / cm 2 , about 200 mW / cm 2 ~ about 250 mW / cm 2 , about 200 mW / cm 2 ~ about 300 mW / cm 2 , or about 250 mW / cm 2 ~ about 300 mW / cm 2 includes infrared light including an average irradiance region of.

[0129] In some embodiments, the disclosed method of treating an autistic disorder is, for example, about 30 J / cm 2 ~ about 50 J / cm 2 , about 30 J / cm 2 ~ about 75 J / cm 2 , about 30 J / cm 2 ~ about 100 J / cm 2 , about 30 J / cm 2 ~ about 125 J / cm 2 , about 30 J / cm 2 ~ about 150 J / cm 2 , about 50 J / cm 2 ~ about 75 J / cm 2 , about 50 J / cm 2 ~ about 100 J / cm 2 , about 50 J / cm 2 ~ about 125 J / cm 2 , about 50 J / cm 2 ~ about 150 J / cm 2 , about 75 J / cm 2 ~ about 100 J / cm 2 , about 75 J / cm 2 ~ about 125 J / cm2 , about 75 J / cm 2 ~ about 150 J / cm 2 , about 100 J / cm 2 ~ about 125 J / cm 2 , about 100 J / cm 2 ~ about 150 J / cm 2 , or about 100 J / cm 2 ~ about 150 J / cm 2 including infrared light with an average fluence over a body area of about 100 J / cm

[0130] In some embodiments, the disclosed method for treating an autistic disorder involves infrared light, for example, having a total incident energy during a treatment session of about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2.5 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, about 3.0 kJ to about 5.0 kJ, about 3.0 kJ to about 5.5 kJ, about 3.0 kJ to about 6 kJ, about 3.5 kJ to about 4.0 kJ, about 3.5 kJ to about 4.5 kJ, about 3.5 kJ to about 5.0 kJ, about 3.5 kJ to about 5.5 kJ, about 3.5 kJ to about 6 kJ, about 4.0 kJ to about 4.5 kJ, about 4.0 kJ to about 5.0 kJ, about 4.0 kJ to about 5.5 kJ, about 4.0 kJ to about 6 kJ, about 4.5 kJ to about 5.0 kJ, about 4.5 kJ to about 5.5 kJ, about 4.5 kJ to about 6 kJ, about 5.0 kJ to about 5.5 kJ, about 5.0 kJ to about 6 kJ, or about 5.5 kJ to about 6 kJ.

[0131] In some embodiments, the disclosed method of treating an autistic disorder includes infrared light having a total output over a body area of, for example, from about 1,000 mW to about 2,000 mW, from about 1,000 mW to about 3,000 mW, from about 1,000 mW to about 4,000 mW, from about 1,000 mW to about 5,000 mW, from about 1,000 mW to about 6,000 mW, from about 1,000 mW to about 7,000 mW, from about 1,000 mW to about 8,000 mW, from about 1,000 mW to about 9,000 mW, from about 2,000 mW to about 3,000 mW, from about 2,000 mW to about 4,000 mW, from about 2,000 mW to about 5,000 mW, from about 2,000 mW to about 6,000 mW, from about 2,000 mW to about 7,000 mW, from about 2,000 mW to about 8,000 mW, from about 2,000 mW to about 9,000 mW, from about 3,000 mW to about 4,000 mW, from about 3,000 mW to about 5,000 mW, from about 3,000 mW to about 6,000 mW, from about 3,000 mW to about 7,000 mW, from about 3,000 mW to about 8,000 mW, from about 3,000 mW to about 9,000 mW, from about 4,000 mW to about 5,000 mW, from about 4,000 mW to about 6,000 mW, from about 4,000 mW to about 7,000 mW, from about 4,000 mW to about 8,000 mW, from about 4,000 mW to about 9,000 mW, from about 5,000 mW to about 6,000 mW, from about 5,000 mW to about 7,000 mW, from about 5,000 mW to about 8,000 mW, from about 5,000 mW to about 9,000 mW, from about 6,000 mW to about 7,000 mW, from about 6,000 mW to about 8,000 mW, from about 6,000 mW to about 9,000 mW, from about 7,000 mW to about 8,000 mW, from about 7,000 mW to about 9,000 mW, or from about 8,000 mW to about 9,000 mW.

[0132] In aspects of these embodiments, the disclosed method of treating an autistic disorder includes exposing a head region that includes an area of from about 18 cm 2 to about 27 cm 2 . In other aspects of these embodiments, the disclosed method of treating an autistic disorder includes an average irradiance region of from about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence over the head region of from about 30 J / cm 2 to about 150 J / cm 2It includes infrared light that is such, the total incident energy during the treatment session is from about 0.5 kJ to about 6 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method for treating an autistic disorder includes infrared light that includes a total output across the head region from about 900 mW to about 8,100 mW. In yet other aspects of these embodiments, the disclosed method for treating an autistic disorder further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method for treating an autistic disorder can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0133] In aspects of these embodiments, the disclosed method for treating an autistic disorder includes exposing a head region that includes an area of 2 from about 20 cm 2 to about 28 cm. In other aspects of these embodiments, the disclosed method for treating an autistic disorder includes an average irradiance region of from about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region of from about 30 J / cm 2 to about 150 J / cm 2including infrared light that is such, the total incident energy during the treatment session is from about 1.5 kJ to about 3.5 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method of treating an autistic disorder includes infrared light that includes a total output across the head region of from about 1,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method of treating an autistic disorder further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method of treating an autistic disorder can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0134] In aspects of these embodiments, the disclosed method of treating an autistic disorder includes exposing a head region that includes an area of from about 22 cm 2 to about 26 cm 2 . In other aspects of these embodiments, the disclosed method of treating an autistic disorder includes an average irradiance region of from about 250 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region of from about 150 J / cm 2 to about 200 J / cm 2It includes infrared light that is such, the total incident energy during the treatment session is about 4 kJ to about 5 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method for treating an autistic disorder includes infrared light having a total output across the head region of about 3,000 mW to about 8,400 mW. In yet other aspects of these embodiments, the disclosed method for treating an autistic disorder further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for treating an autistic disorder can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0135] This specification discloses that a method for treating an individual's attention deficit hyperactivity disorder using photobiomodulation therapy includes exposing the head region to infrared light from the photobiomodulation therapy clothing disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include the frontal region, the temporal region, the occipital region, or any combination thereof.

[0136] In some embodiments, the disclosed method for treating attention deficit hyperactivity disorder is, for example, about 10 cm 2 ~ about 15 cm 2 、about 10 cm 2 ~ about 20 cm 2 、about 10 cm 2 ~ about 25 cm 2 、about 10 cm 2 ~ about 30 cm 2 、about 10 cm 2 ~ about 35 cm 2, about 10 cm 2 ~ about 40 cm 2 , about 10 cm 2 ~ about 45 cm 2 , about 10 cm 2 ~ about 50 cm 2 , about 15 cm 2 ~ about 20 cm 2 , about 15 cm 2 ~ about 25 cm 2 , about 15 cm 2 ~ about 30 cm 2 , about 15 cm 2 ~ about 35 cm 2 , about 15 cm 2 ~ about 40 cm 2 , about 15 cm 2 ~ about 45 cm 2 , about 15 cm 2 ~ about 50 cm 2 , about 20 cm 2 ~ about 25 cm 2 , about 20 cm 2 ~ about 30 cm 2 , about 20 cm 2 ~ about 35 cm 2 , about 20 cm 2 ~ about 40 cm 2 , about 20 cm 2 ~ about 45 cm 2 , about 20 cm 2 ~ about 50 cm 2、 about 25 cm 2 ~ about 30 cm 2 , about 25 cm 2 ~ about 35 cm 2 , about 25 cm 2 ~ about 40 cm 2 , about 25 cm 2 ~ about 45 cm 2 , about 25 cm 2 ~ about 50 cm 2 , about 30 cm 2 ~ about 35 cm 2 , about 30 cm 2 ~ about 40 cm 2 , about 30 cm 2 ~ about 45 cm 2 , or about 30 cm 2 ~ about 50 cm 2 including exposing a head region including an area of

[0137] In some embodiments, the disclosed method of treating attention deficit hyperactivity disorder can include a single treatment session or multiple treatment sessions. In aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder can include, for example, about 1 to about 5 treatment sessions, about 1 to about 10 treatment sessions, about 1 to about 15 treatment sessions, about 1 to about 20 treatment sessions, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions. In other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder can include multiple treatment sessions that continue for several months or years.

[0138] In some embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes exposing the head region to infrared light during a treatment session for, for example, between about 5 minutes and about 10 minutes, about 5 minutes and about 15 minutes, about 5 minutes and about 20 minutes, about 5 minutes and about 25 minutes, about 5 minutes and about 30 minutes, about 5 minutes and about 35 minutes, about 5 minutes and about 40 minutes, about 10 minutes and about 15 minutes, about 10 minutes and about 20 minutes, about 10 minutes and about 25 minutes, about 10 minutes and about 30 minutes, about 10 minutes and about 35 minutes, about 10 minutes and about 40 minutes, about 15 minutes and about 20 minutes, about 15 minutes and about 25 minutes, about 15 minutes and about 30 minutes, about 15 minutes and about 35 minutes, or about 15 minutes and about 40 minutes.

[0139] In some embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes, for example, about 50 mW / cm 2 ~ about 100 mW / cm 2 、 about 50 mW / cm 2 ~ about 150 mW / cm 2 、 about 50 mW / cm 2 ~ about 200 mW / cm 2 、 about 50 mW / cm 2 ~ about 250 mW / cm 2 、 about 50 mW / cm 2~about 300 mW / cm 2 、about 100 mW / cm 2 ~about 150 mW / cm 2 、about 100 mW / cm 2 ~about 200 mW / cm 2 、about 100 mW / cm 2 ~about 250 mW / cm 2 、about 100 mW / cm 2 ~about 300 mW / cm 2 、about 150 mW / cm 2 ~about 200 mW / cm 2 、about 150 mW / cm 2 ~about 250 mW / cm 2 、about 150 mW / cm 2 ~about 300 mW / cm 2 、about 200 mW / cm 2 ~about 250 mW / cm 2 、about 200 mW / cm 2 ~about 300 mW / cm 2 、or about 250 mW / cm 2 ~about 300 mW / cm 2 includes infrared light including an average irradiance region of.

[0140] In some embodiments, the disclosed method of treating attention deficit hyperactivity disorder is, for example, about 30 J / cm 2 ~about 50 J / cm 2 、about 30 J / cm 2 ~about 75 J / cm 2 、about 30 J / cm 2 ~about 100 J / cm 2 、about 30 J / cm 2 ~about 125 J / cm 2 、about 30 J / cm 2 ~about 150 J / cm 2 、about 50 J / cm 2 ~about 75 J / cm 2 、about 50 J / cm 2 ~about 100 J / cm 2 、about 50 J / cm 2 ~about 125 J / cm 2 、about 50 J / cm 2 ~about 150 J / cm 2 、about 75 J / cm 2 ~about 100 J / cm2 and about 75 J / cm 2 to about 125 J / cm 2 and about 75 J / cm 2 to about 150 J / cm 2 and about 100 J / cm 2 to about 125 J / cm 2 and about 100 J / cm 2 to about 150 J / cm 2 or about 100 J / cm 2 to about 150 J / cm 2 including infrared light with an average fluence over a body area of

[0141] In some embodiments, the disclosed method for treating attention deficit hyperactivity disorder involves infrared light having a total incident energy during a treatment session of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2.5 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, about 3.0 kJ to about 5.0 kJ, about 3.0 kJ to about 5.5 kJ, about 3.0 kJ to about 6 kJ, about 3.5 kJ to about 4.0 kJ, about 3.5 kJ to about 4.5 kJ, about 3.5 kJ to about 5.0 kJ, about 3.5 kJ to about 5.5 kJ, about 3.5 kJ to about 6 kJ, about 4.0 kJ to about 4.5 kJ, about 4.0 kJ to about 5.0 kJ, about 4.0 kJ to about 5.5 kJ, about 4.0 kJ to about 6 kJ, about 4.5 kJ to about 5.0 kJ, about 4.5 kJ to about 5.5 kJ, about 4.5 kJ to about 6 kJ, about 5.0 kJ to about 5.5 kJ, about 5.0 kJ to about 6 kJ, or about 5.5 kJ to about 6 kJ.

[0142] In some embodiments, the disclosed method for treating attention deficit hyperactivity disorder includes infrared light having a total output over a body area of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5,000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about 6,000 mW, about 5,000 mW to about 7,000 mW, about 5,000 mW to about 8,000 mW, about 5,000 mW to about 9,000 mW, about 6,000 mW to about 7,000 mW, about 6,000 mW to about 8,000 mW, about 6,000 mW to about 9,000 mW, about 7,000 mW to about 8,000 mW, about 7,000 mW to about 9,000 mW, or about 8,000 mW to about 9,000 mW.

[0143] In aspects of these embodiments, the disclosed method for treating attention deficit hyperactivity disorder includes exposing a head region that includes an area of about 18 cm 2 to about 27 cm 2 . In other aspects of these embodiments, the disclosed method for treating attention deficit hyperactivity disorder includes an average irradiance region of about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence over the head region of about 30 J / cm 2 to about 150 J / cm2 including infrared light that is such, that the total incident energy during the treatment session is from about 0.5 kJ to about 6 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes infrared light having a total output across the head region of from about 900 mW to about 8,100 mW. In yet other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0144] In aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes exposing a head region that includes an area of from about 20 cm 2 to about 28 cm 2 . In other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes an average irradiance region of from about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region of from about 30 J / cm 2 to about 150 J / cm 2including infrared light such that the total incident energy during a treatment session is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes infrared light having a total output across the head region of about 1,000 mW to about 8,400 mW. In yet other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0145] In aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes exposing a head region that includes an area of about 22 cm 2 to about 26 cm 2 . In other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes an average irradiance region of about 250 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region of about 150 J / cm 2 to about 200 J / cm 2It includes infrared light that is such, that the total incident energy during the treatment session is about 4 kJ to about 5 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder includes infrared light having a total output across the head region of about 3,000 mW to about 8,400 mW. In yet other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method of treating attention deficit hyperactivity disorder can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0146] This specification discloses a method of treating a neurodevelopmental disorder of an individual using photobiomodulation therapy, including exposing the head region to infrared light from the headgear for photobiomodulation therapy disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include the frontal region, the temporal region, the occipital region, or any combination thereof.

[0147] In some embodiments, the disclosed method of treating a neurodevelopmental disorder is, for example, about 10 cm 2 ~ about 15 cm 2 、about 10 cm 2 ~ about 20 cm 2 、about 10 cm 2 ~ about 25 cm 2 、about 10 cm 2 ~ about 30 cm 2 、about 10 cm 2 ~ about 35 cm 2, about 10 cm 2 ~ about 40 cm 2 , about 10 cm 2 ~ about 45 cm 2 , about 10 cm 2 ~ about 50 cm 2 , about 15 cm 2 ~ about 20 cm 2 , about 15 cm 2 ~ about 25 cm 2 , about 15 cm 2 ~ about 30 cm 2 , about 15 cm 2 ~ about 35 cm 2 , about 15 cm 2 ~ about 40 cm 2 , about 15 cm 2 ~ about 45 cm 2 , about 15 cm 2 ~ about 50 cm 2 , about 20 cm 2 ~ about 25 cm 2 , about 20 cm 2 ~ about 30 cm 2 , about 20 cm 2 ~ about 35 cm 2 , about 20 cm 2 ~ about 40 cm 2 , about 20 cm 2 ~ about 45 cm 2 , about 20 cm 2 ~ about 50 cm 2、 about 25 cm 2 ~ about 30 cm 2 , about 25 cm 2 ~ about 35 cm 2 , about 25 cm 2 ~ about 40 cm 2 , about 25 cm 2 ~ about 45 cm 2 , about 25 cm 2 ~ about 50 cm 2 , about 30 cm 2 ~ about 35 cm 2 , about 30 cm 2 ~ about 40 cm 2 , about 30 cm 2 ~ about 45 cm 2 , or about 30 cm 2 ~ about 50 cm 2 including exposing a head region including an area of

[0148] In some embodiments, the disclosed methods for treating neurodevelopmental disorders can include a single treatment session or multiple treatment sessions. In aspects of these embodiments, the disclosed methods for treating neurodevelopmental disorders can include, for example, about 1 to about 5 treatment sessions, about 1 to about 10 treatment sessions, about 1 to about 15 treatment sessions, about 1 to about 20 treatment sessions, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions. In other aspects of these embodiments, the disclosed methods for treating neurodevelopmental disorders can include multiple treatment sessions that continue for several months or years.

[0149] In some embodiments, the disclosed methods for treating neurodevelopmental disorders include exposing the head region to infrared light during a treatment session for, for example, between about 5 minutes and about 10 minutes, about 5 minutes and about 15 minutes, about 5 minutes and about 20 minutes, about 5 minutes and about 25 minutes, about 5 minutes and about 30 minutes, about 5 minutes and about 35 minutes, about 5 minutes and about 40 minutes, about 10 minutes and about 15 minutes, about 10 minutes and about 20 minutes, about 10 minutes and about 25 minutes, about 10 minutes and about 30 minutes, about 10 minutes and about 35 minutes, about 10 minutes and about 40 minutes, about 15 minutes and about 20 minutes, about 15 minutes and about 25 minutes, about 15 minutes and about 30 minutes, about 15 minutes and about 35 minutes, or about 15 minutes and about 40 minutes.

[0150] In some embodiments, the disclosed methods for treating neurodevelopmental disorders include, for example, about 50 mW / cm 2 ~ about 100 mW / cm 2 , about 50 mW / cm 2 ~ about 150 mW / cm 2 , about 50 mW / cm 2 ~ about 200 mW / cm 2 , about 50 mW / cm 2 ~ about 250 mW / cm 2 , about 50 mW / cm 2 ~ about 300 mW / cm 2, about 100 mW / cm 2 ~ about 150 mW / cm 2 , about 100 mW / cm 2 ~ about 200 mW / cm 2 , about 100 mW / cm 2 ~ about 250 mW / cm 2 , about 100 mW / cm 2 ~ about 300 mW / cm 2 , about 150 mW / cm 2 ~ about 200 mW / cm 2 , about 150 mW / cm 2 ~ about 250 mW / cm 2 , about 150 mW / cm 2 ~ about 300 mW / cm 2 , about 200 mW / cm 2 ~ about 250 mW / cm 2 , about 200 mW / cm 2 ~ about 300 mW / cm 2 , or about 250 mW / cm 2 ~ about 300 mW / cm 2 includes infrared light including an average irradiance region of...

[0151] In some embodiments, the disclosed method for treating a neurodevelopmental disorder is, for example, about 30 J / cm 2 ~ about 50 J / cm 2 , about 30 J / cm 2 ~ about 75 J / cm 2 , about 30 J / cm 2 ~ about 100 J / cm 2 , about 30 J / cm 2 ~ about 125 J / cm 2 , about 30 J / cm 2 ~ about 150 J / cm 2 , about 50 J / cm 2 ~ about 75 J / cm 2 , about 50 J / cm 2 ~ about 100 J / cm 2 , about 50 J / cm 2 ~ about 125 J / cm 2 , about 50 J / cm 2 ~ about 150 J / cm 2 , about 75 J / cm 2 ~ about 100 J / cm 2 , about 75 J / cm2 ~ about 125 J / cm 2 , about 75 J / cm 2 ~ about 150 J / cm 2 , about 100 J / cm 2 ~ about 125 J / cm 2 , about 100 J / cm 2 ~ about 150 J / cm 2 , or about 100 J / cm 2 ~ about 150 J / cm 2 including infrared light including an average fluence over a body region of ~ about 125 J / cm, about 75 J / cm, ~ about 150 J / cm, about 100 J / cm, ~ about 125 J / cm, about 100 J / cm, ~ about 150 J / cm, or about 100 J / cm ~ about 150 J / cm.

[0152] In some embodiments, the disclosed method for treating neurodevelopmental disorders includes infrared light having a total incident energy during a treatment session of, for example, from about 0.5 kJ to about 1.0 kJ, from about 0.5 kJ to about 1.5 kJ, from about 0.5 kJ to about 2.0 kJ, from about 0.5 kJ to about 2.5 kJ, from about 0.5 kJ to about 3.0 kJ, from about 0.5 kJ to about 3.5 kJ, from about 0.5 kJ to about 4.0 kJ, from about 0.5 kJ to about 4.5 kJ, from about 0.5 kJ to about 5.0 kJ, from about 0.5 kJ to about 5.5 kJ, from about 0.5 kJ to about 6 kJ, from about 1.0 kJ to about 1.5 kJ, from about 1.0 kJ to about 2.0 kJ, from about 1.0 kJ to about 2.5 kJ, from about 1.0 kJ to about 3.0 kJ, from about 1.0 kJ to about 3.5 kJ, from about 1.0 kJ to about 4.0 kJ, from about 1.0 kJ to about 4.5 kJ, from about 1.0 kJ to about 5.0 kJ, from about 1.0 kJ to about 5.5 kJ, from about 1.0 kJ to about 6 kJ, from about 1.5 kJ to about 2.0 kJ, from about 1.5 kJ to about 2.5 kJ, from about 1.5 kJ to about 3.0 kJ, from about 1.5 kJ to about 3.5 kJ, from about 1.5 kJ to about 4.0 kJ, from about 1.5 kJ to about 4.5 kJ, from about 1.5 kJ to about 5.0 kJ, from about 1.5 kJ to about 5.5 kJ, from about 1.5 kJ to about 6 kJ, from about 2.0 kJ to about 2.5 kJ, from about 2.0 kJ to about 3.0 kJ, from about 2.0 kJ to about 3.5 kJ, from about 2.0 kJ to about 4.0 kJ, from about 2.0 kJ to about 4.5 kJ, from about 2.0 kJ to about 5.0 kJ, from about 2.0 kJ to about 5.5 kJ, from about 2.0 kJ to about 6 kJ, from about 2.5 kJ to about 3.0 kJ, from about 2.5 kJ to about 3.5 kJ, from about 2.5 kJ to about 4.0 kJ, from about 2.5 kJ to about 4.5 kJ, from about 2.5 kJ to about 5.0 kJ, from about 2.5 kJ to about 5.5 kJ, from about 2.5 kJ to about 6 kJ, from about 3.0 kJ to about 3.5 kJ, from about 3.0 kJ to about 4.0 kJ, from about 3.0 kJ to about 4.5 kJ, from about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0153] In some embodiments, the disclosed method of treating a neurodevelopmental disorder includes infrared light having a total output over a body area of, for example, from about 1,000 mW to about 2,000 mW, from about 1,000 mW to about 3,000 mW, from about 1,000 mW to about 4,000 mW, from about 1,000 mW to about 5,000 mW, from about 1,000 mW to about 6,000 mW, from about 1,000 mW to about 7,000 mW, from about 1,000 mW to about 8,000 mW, from about 1,000 mW to about 9,000 mW, from about 2,000 mW to about 3,000 mW, from about 2,000 mW to about 4,000 mW, from about 2,000 mW to about 5,000 mW, from about 2,000 mW to about 6,000 mW, from about 2,000 mW to about 7,000 mW, from about 2,000 mW to about 8,000 mW, from about 2,000 mW to about 9,000 mW, from about 3,000 mW to about 4,000 mW, from about 3,000 mW to about 5,000 mW, from about 3,000 mW to about 6,000 mW, from about 3,000 mW to about 7,000 mW, from about 3,000 mW to about 8,000 mW, from about 3,000 mW to about 9,000 mW, from about 4,000 mW to about 5,000 mW, from about 4,000 mW to about 6,000 mW, from about 4,000 mW to about 7,000 mW, from about 4,000 mW to about 8,000 mW, from about 4,000 mW to about 9,000 mW, from about 5,000 mW to about 6,000 mW, from about 5,000 mW to about 7,000 mW, from about 5,000 mW to about 8,000 mW, from about 5,000 mW to about 9,000 mW, from about 6,000 mW to about 7,000 mW, from about 6,000 mW to about 8,000 mW, from about 6,000 mW to about 9,000 mW, from about 7,000 mW to about 8,000 mW, from about 7,000 mW to about 9,000 mW, or from about 8,000 mW to about 9,000 mW.

[0154] In aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder includes exposing a head region that includes an area of from about 18 cm 2 to about 27 cm 2 . In other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder includes an average irradiance region of from about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the head region of from about 30 J / cm 2 to about 150 J / cm 2including infrared light that is such, that the total incident energy during a treatment session is from about 0.5 kJ to about 6 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder includes infrared light that includes a total output across the head region from about 900 mW to about 8,100 mW. In still other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0155] In aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder includes exposing a head region that includes an area from about 20 cm 2 to about 28 cm 2 . In other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder includes an average irradiance region from about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region from about 30 J / cm 2 to about 150 J / cm 2including infrared light such that the total incident energy during a treatment session is from about 1.5 kJ to about 3.5 kJ, or any combination thereof. In yet other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders includes infrared light having a total output across the head region from about 1,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0156] In aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders includes exposing a head region that includes an area from about 22 cm 2 to about 26 cm 2 . In other aspects of these embodiments, the disclosed method for treating neurodevelopmental disorders includes an average irradiance area from about 250 mW / cm 2 to about 300 mW / cm 2 and an average fluence across the head region from about 150 J / cm 2 to about 200 J / cm 2including infrared light that is, has a total incident energy during a treatment session of from about 4 kJ to about 5 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder includes infrared light having a total output over the head region of from about 3,000 mW to about 8,400 mW. In yet other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method of treating a neurodevelopmental disorder can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0157] This specification discloses a method of treating a neurodegenerative disorder of an individual using photobiomodulation therapy, including exposing the head region to infrared light from the headgear for photobiomodulation therapy disclosed herein for one or more treatment sessions. Non-limiting examples of the head region include the frontal region, the temporal region, the occipital region, or any combination thereof.

[0158] In some embodiments, the disclosed method of treating a neurodegenerative disorder is, for example, from about 10 cm 2 to about 15 cm 2 , from about 10 cm 2 to about 20 cm 2 , from about 10 cm 2 to about 25 cm 2 , from about 10 cm 2 to about 30 cm 2 , from about 10 cm 2 to about 35 cm 2 , from about 10 cm2 ~ about 40 cm 2 , about 10 cm 2 ~ about 45 cm 2 , about 10 cm 2 ~ about 50 cm 2 , about 15 cm 2 ~ about 20 cm 2 , about 15 cm 2 ~ about 25 cm 2 , about 15 cm 2 ~ about 30 cm 2 , about 15 cm 2 ~ about 35 cm 2 , about 15 cm 2 ~ about 40 cm 2 , about 15 cm 2 ~ about 45 cm 2 , about 15 cm 2 ~ about 50 cm 2 , about 20 cm 2 ~ about 25 cm 2 , about 20 cm 2 ~ about 30 cm 2 , about 20 cm 2 ~ about 35 cm 2 , about 20 cm 2 ~ about 40 cm 2 , about 20 cm 2 ~ about 45 cm 2 , about 20 cm 2 ~ about 50 cm 2、 about 25 cm 2 ~ about 30 cm 2 , about 25 cm 2 ~ about 35 cm 2 , about 25 cm 2 ~ about 40 cm 2 , about 25 cm 2 ~ about 45 cm 2 , about 25 cm 2 ~ about 50 cm 2 , about 30 cm 2 ~ about 35 cm 2 , about 30 cm 2 ~ about 40 cm 2 , about 30 cm 2 ~ about 45 cm 2 , or about 30 cm 2 ~ about 50 cm 2 including exposing a head region including an area of

[0159] In some embodiments, the disclosed method of treating a neurodegenerative disease can include a single treatment session or multiple treatment sessions. In aspects of these embodiments, the disclosed method of treating a neurodegenerative disease can include, for example, about 1 to about 5 treatment sessions, about 1 to about 10 treatment sessions, about 1 to about 15 treatment sessions, about 1 to about 20 treatment sessions, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions. In other aspects of these embodiments, the disclosed method of treating a neurodegenerative disease can include multiple treatment sessions that continue for several months or years.

[0160] In some embodiments, the disclosed method of treating a neurodegenerative disease includes exposing the head region to infrared light during a treatment session, for example, for about 5 minutes to about 10 minutes, about 5 minutes to about 15 minutes, about 5 minutes to about 20 minutes, about 5 minutes to about 25 minutes, about 5 minutes to about 30 minutes, about 5 minutes to about 35 minutes, about 5 minutes to about 40 minutes, about 10 minutes to about 15 minutes, about 10 minutes to about 20 minutes, about 10 minutes to about 25 minutes, about 10 minutes to about 30 minutes, about 10 minutes to about 35 minutes, about 10 minutes to about 40 minutes, about 15 minutes to about 20 minutes, about 15 minutes to about 25 minutes, about 15 minutes to about 30 minutes, about 15 minutes to about 35 minutes, or about 15 minutes to about 40 minutes.

[0161] In some embodiments, the disclosed method of treating a neurodegenerative disease is, for example, about 50 mW / cm 2 ~ about 100 mW / cm 2 、 about 50 mW / cm 2 ~ about 150 mW / cm 2 、 about 50 mW / cm 2 ~ about 200 mW / cm 2 、 about 50 mW / cm 2 ~ about 250 mW / cm 2 、 about 50 mW / cm 2 ~ about 300 mW / cm2 , about 100 mW / cm 2 ~ about 150 mW / cm 2 , about 100 mW / cm 2 ~ about 200 mW / cm 2 , about 100 mW / cm 2 ~ about 250 mW / cm 2 , about 100 mW / cm 2 ~ about 300 mW / cm 2 , about 150 mW / cm 2 ~ about 200 mW / cm 2 , about 150 mW / cm 2 ~ about 250 mW / cm 2 , about 150 mW / cm 2 ~ about 300 mW / cm 2 , about 200 mW / cm 2 ~ about 250 mW / cm 2 , about 200 mW / cm 2 ~ about 300 mW / cm 2 , or about 250 mW / cm 2 ~ about 300 mW / cm 2 includes infrared light including an average irradiance region of.

[0162] In some embodiments, the disclosed method of treating a neurodegenerative disease is, for example, about 30 J / cm 2 ~ about 50 J / cm 2 , about 30 J / cm 2 ~ about 75 J / cm 2 , about 30 J / cm 2 ~ about 100 J / cm 2 , about 30 J / cm 2 ~ about 125 J / cm 2 , about 30 J / cm 2 ~ about 150 J / cm 2 , about 50 J / cm 2 ~ about 75 J / cm 2 , about 50 J / cm 2 ~ about 100 J / cm 2 , about 50 J / cm 2 ~ about 125 J / cm 2 , about 50 J / cm 2 ~ about 150 J / cm 2 , about 75 J / cm 2 ~ about 100 J / cm 2, about 75 J / cm 2 ~ about 125 J / cm 2 , about 75 J / cm 2 ~ about 150 J / cm 2 , about 100 J / cm 2 ~ about 125 J / cm 2 , about 100 J / cm 2 ~ about 150 J / cm 2 , or about 100 J / cm 2 ~ about 150 J / cm 2 and includes infrared light having an average fluence over a body region of about 100 J / cm

[0163] In some embodiments, the disclosed method of treating a neurodegenerative disorder includes infrared light having a total incident energy during a treatment session of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2.5 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, about 3.0 kJ to about 5.0 kJ, about 3.0 kJ to about 5.5 kJ, about 3.0 kJ to about 6 kJ, about 3.5 kJ to about 4.0 kJ, about 3.5 kJ to about 4.5 kJ, about 3.5 kJ to about 5.0 kJ, about 3.5 kJ to about 5.5 kJ, about 3.5 kJ to about 6 kJ, about 4.0 kJ to about 4.5 kJ, about 4.0 kJ to about 5.0 kJ, about 4.0 kJ to about 5.5 kJ, about 4.0 kJ to about 6 kJ, about 4.5 kJ to about 5.0 kJ, about 4.5 kJ to about 5.5 kJ, about 4.5 kJ to about 6 kJ, about 5.0 kJ to about 5.5 kJ, about 5.0 kJ to about 6 kJ, or about 5.5 kJ to about 6 kJ.

[0164] In some embodiments, the disclosed method for treating a neurodegenerative disorder includes infrared light having a total output over a body area of, for example, from about 1,000 mW to about 2,000 mW, from about 1,000 mW to about 3,000 mW, from about 1,000 mW to about 4,000 mW, from about 1,000 mW to about 5,000 mW, from about 1,000 mW to about 6,000 mW, from about 1,000 mW to about 7,000 mW, from about 1,000 mW to about 8,000 mW, from about 1,000 mW to about 9,000 mW, from about 2,000 mW to about 3,000 mW, from about 2,000 mW to about 4,000 mW, from about 2,000 mW to about 5,000 mW, from about 2,000 mW to about 6,000 mW, from about 2,000 mW to about 7,000 mW, from about 2,000 mW to about 8,000 mW, from about 2,000 mW to about 9,000 mW, from about 3,000 mW to about 4,000 mW, from about 3,000 mW to about 5,000 mW, from about 3,000 mW to about 6,000 mW, from about 3,000 mW to about 7,000 mW, from about 3,000 mW to about 8,000 mW, from about 3,000 mW to about 9,000 mW, from about 4,000 mW to about 5,000 mW, from about 4,000 mW to about 6,000 mW, from about 4,000 mW to about 7,000 mW, from about 4,000 mW to about 8,000 mW, from about 4,000 mW to about 9,000 mW, from about 5,000 mW to about 6,000 mW, from about 5,000 mW to about 7,000 mW, from about 5,000 mW to about 8,000 mW, from about 5,000 mW to about 9,000 mW, from about 6,000 mW to about 7,000 mW, from about 6,000 mW to about 8,000 mW, from about 6,000 mW to about 9,000 mW, from about 7,000 mW to about 8,000 mW, from about 7,000 mW to about 9,000 mW, or from about 8,000 mW to about 9,000 mW.

[0165] In aspects of these embodiments, the disclosed method for treating a neurodegenerative disorder includes exposing a head region that includes an area of about 18 cm 2 to about 27 cm 2 . In other aspects of these embodiments, the disclosed method for treating a neurodegenerative disorder includes an average irradiance region of about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence over the head region of about 30 J / cm 2 to about 150 J / cm2 including infrared light such that the total incident energy during a treatment session is about 0.5 kJ to about 6 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method of treating a cognitive neurodegenerative disease includes infrared light having a total output across the head region of about 900 mW to about 8,100 mW. In yet other aspects of these embodiments, the disclosed method of treating a cognitive neurodegenerative disease further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the headgear for transcranial photobiomodulation therapy disclosed herein. In other aspects of these embodiments, the disclosed method of treating a cognitive neurodegenerative disease can include a single treatment session or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0166] In aspects of these embodiments, the disclosed method of treating a cognitive neurodegenerative disease includes exposing a head region that includes an area of about 20 cm 2 to about 28 cm 2 . In other aspects of these embodiments, the disclosed method of treating a cognitive neurodegenerative disease includes an average irradiance region of about 50 mW / cm 2 to about 300 mW / cm 2 , and an average fluence across the head region of about 30 J / cm 2 to about 150 J / cm 2It includes infrared light that has the following characteristics: the total incident energy during the treatment session is about 1.5 kJ to about 3.5 kJ, or any combination thereof. In yet other aspects of these embodiments, the disclosed method for treating a cognitive neurodegenerative disease includes infrared light having a total output across the head region of about 1,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method for treating a cognitive neurodegenerative disease further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the head-mounted photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for treating a cognitive neurodegenerative disease can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0167] In aspects of these embodiments, the disclosed method for treating a cognitive neurodegenerative disease includes exposing a head region that includes an area of 2 from about 22 cm 2 to about 26 cm. In other aspects of these embodiments, the disclosed method for treating a cognitive neurodegenerative disease includes an average irradiance region of about 250 mW / cm 2 to about 300 mW / cm, and an average fluence across the head region of about 150 J / cm 2 to about 200 J / cm 2 to about 200 J / cm 2It includes infrared light that is such and has a total incident energy during a treatment session of about 4 kJ to about 5 kJ, or any combination thereof. In still other aspects of these embodiments, the disclosed method for treating a neurodegenerative disease includes infrared light having a total output across the head region of about 3,000 mW to about 8,400 mW. In yet other aspects of these embodiments, the disclosed method for treating a neurodegenerative disease further includes transcranial direct current stimulation therapy. Both photobiomodulation therapy and transcranial direct current stimulation therapy can be administered using the transcranial photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method for treating a neurodegenerative disease can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0168] Photobiomodulation therapy using the clothing for photobiomodulation therapy disclosed herein can be applied to the trunk or regions thereof, or to the extremities such as one or both arms or regions thereof or one or both legs or regions thereof. Such non-invasive light-based neuromodulation therapy does not require medication and provides long-term benefits by changing the way the user's nervous system functions at the neuronal level by providing various positive photochemical reactions. For example, photobiomodulation therapy can increase neuronal mitochondrial energy and adenosine triphosphate (ATP) production by enhancing cytochrome c oxidase activity, and as a result, can increase cellular energy production. In addition, the transmission of light energy can also suppress inflammation at the cellular and tissue levels, generate reactive oxygen species (ROS) that can improve cell repair and healing, and induce nitric oxide (NO) production, which is important for good vascular health and optimal blood flow, nutrient delivery, and waste removal. This is important because body regions receiving inadequate blood flow and circulation can be detrimental and may slow the healing time of wounds, ischemia, and / or necrosis. The enhancement of cellular energy and the increase in blood flow result in increased neurogenesis and neuroplasticity, increased neuroprotection, enhanced nerve repair, and reduced inflammation.

[0169] This specification discloses a method of improving an individual's vascular hemodynamics using photobiomodulation therapy, the method comprising exposing a body region to infrared light from the clothing for photobiomodulation therapy disclosed herein for one or more treatment sessions. In aspects of these embodiments, the disclosed method of improving vascular hemodynamics comprises exposing a body region including a region of the trunk, a region of an arm, a region of a leg, or any combination thereof. Non-limiting examples of regions of the trunk include the abdominal region, the back region, the shoulder region, or any combination thereof. Non-limiting examples of regions of an arm include the upper arm region, the forearm region, or the hand. Non-limiting examples of regions of a leg include the thigh region, the lower leg region, or the foot.

[0170] In some embodiments, the disclosed method for improving vascular hemodynamics is, for example, about 10 cm 2 to about 25 cm 2 , about 10 cm 2 to about 50 cm 2 , about 10 cm 2 to about 75 cm 2 , about 10 cm 2 to about 100 cm 2 , about 10 cm 2 to about 125 cm 2 , about 10 cm 2 to about 150 cm 2 , about 10 cm 2 to about 175 cm 2 , about 10 cm 2 to about 200 cm 2 , about 10 cm 2 to about 225 cm 2 , about 10 cm 2 to about 250 cm 2 , about 10 cm 2 to about 275 cm 2 , about 10 cm 2 to about 300 cm 2 , about 25 cm 2 to about 50 cm 2 , about 25 cm 2 to about 75 cm 2 , about 25 cm 2 to about 100 cm 2 , about 25 cm 2 to about 125 cm 2 , about 25 cm 2 to about 150 cm 2 , about 25 cm 2 to about 175 cm 2 , about 25 cm 2 to about 200 cm 2 , about 25 cm 2 to about 225 cm 2 , about 25 cm 2 to about 250 cm 2 , about 25 cm 2 to about 275 cm 2 , about 25 cm 2 to about 300 cm 2 , about 50 cm 2 to about 75 cm 2 , about 50 cm 2~about 100 cm 2 、about 50 cm 2 ~about 125 cm 2 、about 50 cm 2 ~about 150 cm 2 、about 50 cm 2 ~about 175 cm 2 、about 50 cm 2 ~about 200 cm 2 、about 50 cm 2 ~about 225 cm 2 、about 50 cm 2 ~about 250 cm 2 、about 50 cm 2 ~about 275 cm 2 、about 50 cm 2 ~about 300 cm 2 、about 75 cm 2 ~about 100 cm 2 、about 75 cm 2 ~about 125 cm 2 、about 75 cm 2 ~about 150 cm 2 、about 75 cm 2 ~about 175 cm 2 、about 75 cm 2 ~about 200 cm 2 、about 75 cm 2 ~about 225 cm 2 、about 75 cm 2 ~about 250 cm 2 、about 75 cm 2 ~about 275 cm 2 、about 75 cm 2 ~about 300 cm 2 、about 100 cm 2 ~about 125 cm 2 、about 100 cm 2 ~about 150 cm 2 、about 100 cm 2 ~about 175 cm 2 、about 100 cm 2 ~about 200 cm 2 、about 100 cm 2 ~about 225 cm 2 、about 100 cm 2 ~about 250 cm 2 、about 100 cm 2 ~about 275 cm 2 、or about 100 cm 2 ~about 300 cm2 including exposing a head region that includes the area of 2 .

[0171] In some embodiments, the disclosed method of improving vascular hemodynamics can include a single treatment session or multiple treatment sessions. In aspects of these embodiments, the disclosed method of improving vascular hemodynamics can include, for example, from about 1 to about 5 treatment sessions, from about 1 to about 10 treatment sessions, from about 1 to about 15 treatment sessions, from about 1 to about 20 treatment sessions, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions. In other aspects of these embodiments, the disclosed method of improving vascular hemodynamics can include multiple treatment sessions that continue for several months or years.

[0172] In some embodiments, the disclosed method of improving vascular hemodynamics includes exposing the head region to infrared light during a treatment session for, for example, between about 5 minutes and about 10 minutes, between about 5 minutes and about 15 minutes, between about 5 minutes and about 20 minutes, between about 5 minutes and about 25 minutes, between about 5 minutes and about 30 minutes, between about 5 minutes and about 35 minutes, between about 5 minutes and about 40 minutes, between about 10 minutes and about 15 minutes, between about 10 minutes and about 20 minutes, between about 10 minutes and about 25 minutes, between about 10 minutes and about 30 minutes, between about 10 minutes and about 35 minutes, between about 10 minutes and about 40 minutes, between about 15 minutes and about 20 minutes, between about 15 minutes and about 25 minutes, between about 15 minutes and about 30 minutes, between about 15 minutes and about 35 minutes, or between about 15 minutes and about 40 minutes.

[0173] In some embodiments, the disclosed method of improving vascular hemodynamics is, for example, from about 50 mW / cm 2 to about 100 mW / cm 2 , from about 50 mW / cm 2 to about 150 mW / cm 2 , from about 50 mW / cm 2 to about 200 mW / cm 2 , from about 50 mW / cm 2~about 250 mW / cm 2 、about 50 mW / cm 2 ~about 300 mW / cm 2 、about 100 mW / cm 2 ~about 150 mW / cm 2 、about 100 mW / cm 2 ~about 200 mW / cm 2 、about 100 mW / cm 2 ~about 250 mW / cm 2 、about 100 mW / cm 2 ~about 300 mW / cm 2 、about 150 mW / cm 2 ~about 200 mW / cm 2 、about 150 mW / cm 2 ~about 250 mW / cm 2 、about 150 mW / cm 2 ~about 300 mW / cm 2 、about 200 mW / cm 2 ~about 250 mW / cm 2 、about 200 mW / cm 2 ~about 300 mW / cm 2 、or about 250 mW / cm 2 ~about 300 mW / cm 2 includes infrared light including an average irradiance region of about 250 mW / cm to about 300 mW / cm.

[0174] In some embodiments, the disclosed method for improving vascular hemodynamics is, for example, about 30 J / cm 2 ~about 50 J / cm 2 、about 30 J / cm 2 ~about 75 J / cm 2 、about 30 J / cm 2 ~about 100 J / cm 2 、about 30 J / cm 2 ~about 125 J / cm 2 、about 30 J / cm 2 ~about 150 J / cm 2 、about 50 J / cm 2 ~about 75 J / cm 2 、about 50 J / cm 2 ~about 100 J / cm 2 、about 50 J / cm 2 ~about 125 J / cm 2 、about 50 J / cm 2 ~about 150 J / cm2 , about 75 J / cm 2 ~ about 100 J / cm 2 , about 75 J / cm 2 ~ about 125 J / cm 2 , about 75 J / cm 2 ~ about 150 J / cm 2 , about 100 J / cm 2 ~ about 125 J / cm 2 , about 100 J / cm 2 ~ about 150 J / cm 2 , or about 100 J / cm 2 ~ about 150 J / cm 2 includes infrared light including an average fluence over a body region of about 150 J / cm.

[0175] In some embodiments, the disclosed method for improving vascular hemodynamics includes infrared light having a total incident energy during a treatment session of, for example, from about 0.5 kJ to about 1.0 kJ, from about 0.5 kJ to about 1.5 kJ, from about 0.5 kJ to about 2.0 kJ, from about 0.5 kJ to about 2.5 kJ, from about 0.5 kJ to about 3.0 kJ, from about 0.5 kJ to about 3.5 kJ, from about 0.5 kJ to about 4.0 kJ, from about 0.5 kJ to about 4.5 kJ, from about 0.5 kJ to about 5.0 kJ, from about 0.5 kJ to about 5.5 kJ, from about 0.5 kJ to about 6 kJ, from about 1.0 kJ to about 1.5 kJ, from about 1.0 kJ to about 2.0 kJ, from about 1.0 kJ to about 2.5 kJ, from about 1.0 kJ to about 3.0 kJ, from about 1.0 kJ to about 3.5 kJ, from about 1.0 kJ to about 4.0 kJ, from about 1.0 kJ to about 4.5 kJ, from about 1.0 kJ to about 5.0 kJ, from about 1.0 kJ to about 5.5 kJ, from about 1.0 kJ to about 6 kJ, from about 1.5 kJ to about 2.0 kJ, from about 1.5 kJ to about 2.5 kJ, from about 1.5 kJ to about 3.0 kJ, from about 1.5 kJ to about 3.5 kJ, from about 1.5 kJ to about 4.0 kJ, from about 1.5 kJ to about 4.5 kJ, from about 1.5 kJ to about 5.0 kJ, from about 1.5 kJ to about 5.5 kJ, from about 1.5 kJ to about 6 kJ, from about 2.0 kJ to about 2.5 kJ, from about 2.0 kJ to about 3.0 kJ, from about 2.0 kJ to about 3.5 kJ, from about 2.0 kJ to about 4.0 kJ, from about 2.0 kJ to about 4.5 kJ, from about 2.0 kJ to about 5.0 kJ, from about 2.0 kJ to about 5.5 kJ, from about 2.0 kJ to about 6 kJ, from about 2.5 kJ to about 3.0 kJ, from about 2.5 kJ to about 3.5 kJ, from about 2.5 kJ to about 4.0 kJ, from about 2.5 kJ to about 4.5 kJ, from about 2.5 kJ to about 5.0 kJ, from about 2.5 kJ to about 5.5 kJ, from about 2.5 kJ to about 6 kJ, from about 3.0 kJ to about 3.5 kJ, from about 3.0 kJ to about 4.0 kJ, from about 3.0 kJ to about 4.5 kJ, from about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0176] In some embodiments, the disclosed method for improving vascular hemodynamics includes infrared light having a total output over a body region of, for example, from about 1,000 mW to about 2,000 mW, from about 1,000 mW to about 3,000 mW, from about 1,000 mW to about 4,000 mW, from about 1,000 mW to about 5,000 mW, from about 1,000 mW to about 6,000 mW, from about 1,000 mW to about 7,000 mW, from about 1,000 mW to about 8,000 mW, from about 1,000 mW to about 9,000 mW, from about 2,000 mW to about 3,000 mW, from about 2,000 mW to about 4,000 mW, from about 2,000 mW to about 5,000 mW, from about 2,000 mW to about 6,000 mW, from about 2,000 mW to about 7,000 mW, from about 2,000 mW to about 8,000 mW, from about 2,000 mW to about 9,000 mW, from about 3,000 mW to about 4,000 mW, from about 3,000 mW to about 5,000 mW, from about 3,000 mW to about 6,000 mW, from about 3,000 mW to about 7,000 mW, from about 3,000 mW to about 8,000 mW, from about 3,000 mW to about 9,000 mW, from about 4,000 mW to about 5,000 mW, from about 4,000 mW to about 6,000 mW, from about 4,000 mW to about 7,000 mW, from about 4,000 mW to about 8,000 mW, from about 4,000 mW to about 9,000 mW, from about 5,000 mW to about 6,000 mW, from about 5,000 mW to about 7,000 mW, from about 5,000 mW to about 8,000 mW, from about 5,000 mW to about 9,000 mW, from about 6,000 mW to about 7,000 mW, from about 6,000 mW to about 8,000 mW, from about 6,000 mW to about 9,000 mW, from about 7,000 mW to about 8,000 mW, from about 7,000 mW to about 9,000 mW, or from about 8,000 mW to about 9,000 mW.

[0177] In aspects of these embodiments, the disclosed method for improving vascular hemodynamics is an average irradiance region of from about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the body region of from about 30 J / cm 2 to about 150 J / cm 2including infrared light that is such, that the total incident energy during a treatment session is from about 0.5 kJ to about 6 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving vascular hemodynamics includes infrared light having a total output over a body area from about 900 mW to about 8,100 mW. In still other aspects of these embodiments, the disclosed method of improving vascular hemodynamics further includes direct current stimulation therapy to a body area. Both photobiomodulation therapy and direct current stimulation therapy can be administered using the photobiomodulation therapy clothing disclosed herein. In still other aspects of these embodiments, the disclosed method of improving vascular hemodynamics can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0178] In aspects of these embodiments, the disclosed method of improving vascular hemodynamics is from about 50 mW / cm 2 to about 300 mW / cm 2 of average irradiance area, and the average fluence over the body area is from about 30 J / cm 2 to about 150 J / cm 2It includes infrared light that is such and the total incident energy during the treatment session is from about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for improving vascular hemodynamics includes infrared light having a total output over a body area of from about 1,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method for improving vascular hemodynamics further includes direct current stimulation therapy for the body area. Both photobiomodulation therapy and direct current stimulation therapy can be administered using the clothing for photobiomodulation therapy disclosed herein. In yet other aspects of these embodiments, the disclosed method for improving vascular hemodynamics can include a single treatment session or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0179] In aspects of these embodiments, the disclosed method for improving vascular hemodynamics is from about 250 mW / cm 2 to about 300 mW / cm 2 of the average irradiance area, and the average fluence over the body area is from about 150 J / cm 2 to about 200 J / cm 2It includes infrared light that is such, the total incident energy during the treatment session is about 4 kJ to about 5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving vascular hemodynamics includes infrared light having a total output over a body area of about 3,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method of improving vascular hemodynamics further includes direct current stimulation therapy for the body area. Both photobiomodulation therapy and direct current stimulation therapy can be administered using the photobiomodulation therapy clothing disclosed herein. In yet other aspects of these embodiments, the disclosed method of improving vascular hemodynamics can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0180] This specification discloses a method of improving an individual's cytochrome c oxidase redox activity using photobiomodulation therapy, the method including exposing a body area to infrared light from the photobiomodulation therapy clothing disclosed herein for one or more treatment sessions. In aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity includes exposing a body area including an area of the torso, an area of the arm, an area of the leg, or any combination thereof. Non-limiting examples of an area of the torso include an abdominal area, a back area, a shoulder area, or any combination thereof. Non-limiting examples of an area of the arm include an upper arm area, a forearm area, or a hand. Non-limiting examples of an area of the leg include a thigh area, a lower leg area, or a foot.

[0181] In some embodiments, the disclosed method of improving cytochrome c oxidase redox activity is, for example, about 10 cm2 ~ about 25 cm 2 、 about 10 cm 2 ~ about 50 cm 2 、 about 10 cm 2 ~ about 75 cm 2 、 about 10 cm 2 ~ about 100 cm 2 、 about 10 cm 2 ~ about 125 cm 2 、 about 10 cm 2 ~ about 150 cm 2 、 about 10 cm 2 ~ about 175 cm 2 、 about 10 cm 2 ~ about 200 cm 2 、 about 10 cm 2 ~ about 225 cm 2 、 about 10 cm 2 ~ about 250 cm 2 、 about 10 cm 2 ~ about 275 cm 2 、 about 10 cm 2 ~ about 300 cm 2 、 about 25 cm 2 ~ about 50 cm 2 、 about 25 cm 2 ~ about 75 cm 2 、 about 25 cm 2 ~ about 100 cm 2 、 about 25 cm 2 ~ about 125 cm 2 、 about 25 cm 2 ~ about 150 cm 2 、 about 25 cm 2 ~ about 175 cm 2 、 about 25 cm 2 ~ about 200 cm 2 、 about 25 cm 2 ~ about 225 cm 2 、 about 25 cm 2 ~ about 250 cm 2 、 about 25 cm 2 ~ about 275 cm 2 、 about 25 cm 2 ~ about 300 cm 2 、 about 50 cm 2 ~ about 75 cm 2 、 about 50 cm 2 ~ about 100 cm 2 、 about 50 cm 2 ~ about 125 cm 2, about 50 cm 2 ~ about 150 cm 2 , about 50 cm 2 ~ about 175 cm 2 , about 50 cm 2 ~ about 200 cm 2 , about 50 cm 2 ~ about 225 cm 2 , about 50 cm 2 ~ about 250 cm 2 , about 50 cm 2 ~ about 275 cm 2 , about 50 cm 2 ~ about 300 cm 2 , about 75 cm 2 ~ about 100 cm 2 , about 75 cm 2 ~ about 125 cm 2 , about 75 cm 2 ~ about 150 cm 2 , about 75 cm 2 ~ about 175 cm 2 , about 75 cm 2 ~ about 200 cm 2 , about 75 cm 2 ~ about 225 cm 2 , about 75 cm 2 ~ about 250 cm 2 , about 75 cm 2 ~ about 275 cm 2 , about 75 cm 2 ~ about 300 cm 2 , about 100 cm 2 ~ about 125 cm 2 , about 100 cm 2 ~ about 150 cm 2 , about 100 cm 2 ~ about 175 cm 2 , about 100 cm 2 ~ about 200 cm 2 , about 100 cm 2 ~ about 225 cm 2 , about 100 cm 2 ~ about 250 cm 2 , about 100 cm 2 ~ about 275 cm 2 , or about 100 cm 2 ~ about 300 cm 2 including exposing a head region including an area of

[0182] In some embodiments, the disclosed method of improving cytochrome c oxidase redox activity can include a single treatment session or multiple treatment sessions. In aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity can include, for example, about 1 to about 5 treatment sessions, about 1 to about 10 treatment sessions, about 1 to about 15 treatment sessions, about 1 to about 20 treatment sessions, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions. In other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity can include multiple treatment sessions that continue for months or years.

[0183] In some embodiments, the disclosed method of improving cytochrome c oxidase redox activity includes exposing the head region to infrared light during a treatment session for, for example, between about 5 minutes and about 10 minutes, about 5 minutes and about 15 minutes, about 5 minutes and about 20 minutes, about 5 minutes and about 25 minutes, about 5 minutes and about 30 minutes, about 5 minutes and about 35 minutes, about 5 minutes and about 40 minutes, about 10 minutes and about 15 minutes, about 10 minutes and about 20 minutes, about 10 minutes and about 25 minutes, about 10 minutes and about 30 minutes, about 10 minutes and about 35 minutes, about 10 minutes and about 40 minutes, about 15 minutes and about 20 minutes, about 15 minutes and about 25 minutes, about 15 minutes and about 30 minutes, about 15 minutes and about 35 minutes, or about 15 minutes and about 40 minutes.

[0184] In some embodiments, the disclosed method of improving cytochrome c oxidase redox activity is, for example, about 50 mW / cm 2 ~ about 100 mW / cm 2 、 about 50 mW / cm 2 ~ about 150 mW / cm 2 、 about 50 mW / cm 2 ~ about 200 mW / cm 2 、 about 50 mW / cm 2~about 250 mW / cm 2 、about 50 mW / cm 2 ~about 300 mW / cm 2 、about 100 mW / cm 2 ~about 150 mW / cm 2 、about 100 mW / cm 2 ~about 200 mW / cm 2 、about 100 mW / cm 2 ~about 250 mW / cm 2 、about 100 mW / cm 2 ~about 300 mW / cm 2 、about 150 mW / cm 2 ~about 200 mW / cm 2 、about 150 mW / cm 2 ~about 250 mW / cm 2 、about 150 mW / cm 2 ~about 300 mW / cm 2 、about 200 mW / cm 2 ~about 250 mW / cm 2 、about 200 mW / cm 2 ~about 300 mW / cm 2 、or about 250 mW / cm 2 ~about 300 mW / cm 2 includes infrared light including an average irradiance region of.

[0185] In some embodiments, the disclosed method for improving cytochrome c oxidase redox activity is, for example, about 30 J / cm 2 ~about 50 J / cm 2 、about 30 J / cm 2 ~about 75 J / cm 2 、about 30 J / cm 2 ~about 100 J / cm 2 、about 30 J / cm 2 ~about 125 J / cm 2 、about 30 J / cm 2 ~about 150 J / cm 2 、about 50 J / cm 2 ~about 75 J / cm 2 、about 50 J / cm 2 ~about 100 J / cm 2 、about 50 J / cm 2 ~about 125 J / cm 2 、about 50 J / cm 2~about 150 J / cm 2 、about 75 J / cm 2 ~about 100 J / cm 2 、about 75 J / cm 2 ~about 125 J / cm 2 、about 75 J / cm 2 ~about 150 J / cm 2 、about 100 J / cm 2 ~about 125 J / cm 2 、about 100 J / cm 2 ~about 150 J / cm 2 、or about 100 J / cm 2 ~about 150 J / cm 2 including infrared light including an average fluence over a body region of

[0186] In some embodiments, the disclosed method of improving cytochrome c oxidase redox activity involves infrared light having a total incident energy during a treatment session of, for example, about 0.5 kJ to about 1.0 kJ, about 0.5 kJ to about 1.5 kJ, about 0.5 kJ to about 2.0 kJ, about 0.5 kJ to about 2.5 kJ, about 0.5 kJ to about 3.0 kJ, about 0.5 kJ to about 3.5 kJ, about 0.5 kJ to about 4.0 kJ, about 0.5 kJ to about 4.5 kJ, about 0.5 kJ to about 5.0 kJ, about 0.5 kJ to about 5.5 kJ, about 0.5 kJ to about 6 kJ, about 1.0 kJ to about 1.5 kJ, about 1.0 kJ to about 2.0 kJ, about 1.0 kJ to about 2.5 kJ, about 1.0 kJ to about 3.0 kJ, about 1.0 kJ to about 3.5 kJ, about 1.0 kJ to about 4.0 kJ, about 1.0 kJ to about 4.5 kJ, about 1.0 kJ to about 5.0 kJ, about 1.0 kJ to about 5.5 kJ, about 1.0 kJ to about 6 kJ, about 1.5 kJ to about 2.0 kJ, about 1.5 kJ to about 2.5 kJ, about 1.5 kJ to about 3.0 kJ, about 1.5 kJ to about 3.5 kJ, about 1.5 kJ to about 4.0 kJ, about 1.5 kJ to about 4.5 kJ, about 1.5 kJ to about 5.0 kJ, about 1.5 kJ to about 5.5 kJ, about 1.5 kJ to about 6 kJ, about 2.0 kJ to about 2.5 kJ, about 2.0 kJ to about 3.0 kJ, about 2.0 kJ to about 3.5 kJ, about 2.0 kJ to about 4.0 kJ, about 2.0 kJ to about 4.5 kJ, about 2.0 kJ to about 5.0 kJ, about 2.0 kJ to about 5.5 kJ, about 2.0 kJ to about 6 kJ, about 2.5 kJ to about 3.0 kJ, about 2.5 kJ to about 3.5 kJ, about 2.5 kJ to about 4.0 kJ, about 2.5 kJ to about 4.5 kJ, about 2.5 kJ to about 5.0 kJ, about 2.5 kJ to about 5.5 kJ, about 2.5 kJ to about 6 kJ, about 3.0 kJ to about 3.5 kJ, about 3.0 kJ to about 4.0 kJ, about 3.0 kJ to about 4.5 kJ, about 3.0 kJ to about 5.0 kJ, about 3.0 kJ to about 5.5 kJ, about 3.0 kJ to about 6 kJ, about 3.5 kJ to about 4.0 kJ, about 3.5 kJ to about 4.5 kJ, about 3.5 kJ to about 5.0 kJ, about 3.5 kJ to about 5.5 kJ, about 3.5 kJ to about 6 kJ, about 4.0 kJ to about 4.5 kJ, about 4.0 kJ to about 5.0 kJ, about 4.0 kJ to about 5.5 kJ, about 4.0 kJ to about 6 kJ, about 4.5 kJ to about 5.0 kJ, about 4.5 kJ to about 5.5 kJ, about 4.5 kJ to about 6 kJ, about 5.0 kJ to about 5.5 kJ, about 5.0 kJ to about 6 kJ, or about 5.5 kJ to about 6 kJ.

[0187] In some embodiments, the disclosed method of improving cytochrome c oxidase redox activity includes infrared light having a total output over a body area of, for example, from about 1,000 mW to about 2,000 mW, from about 1,000 mW to about 3,000 mW, from about 1,000 mW to about 4,000 mW, from about 1,000 mW to about 5,000 mW, from about 1,000 mW to about 6,000 mW, from about 1,000 mW to about 7,000 mW, from about 1,000 mW to about 8,000 mW, from about 1,000 mW to about 9,000 mW, from about 2,000 mW to about 3,000 mW, from about 2,000 mW to about 4,000 mW, from about 2,000 mW to about 5,000 mW, from about 2,000 mW to about 6,000 mW, from about 2,000 mW to about 7,000 mW, from about 2,000 mW to about 8,000 mW, from about 2,000 mW to about 9,000 mW, from about 3,000 mW to about 4,000 mW, from about 3,000 mW to about 5,000 mW, from about 3,000 mW to about 6,000 mW, from about 3,000 mW to about 7,000 mW, from about 3,000 mW to about 8,000 mW, from about 3,000 mW to about 9,000 mW, from about 4,000 mW to about 5,000 mW, from about 4,000 mW to about 6,000 mW, from about 4,000 mW to about 7,000 mW, from about 4,000 mW to about 8,000 mW, from about 4,000 mW to about 9,000 mW, from about 5,000 mW to about 6,000 mW, from about 5,000 mW to about 7,000 mW, from about 5,000 mW to about 8,000 mW, from about 5,000 mW to about 9,000 mW, from about 6,000 mW to about 7,000 mW, from about 6,000 mW to about 8,000 mW, from about 6,000 mW to about 9,000 mW, from about 7,000 mW to about 8,000 mW, from about 7,000 mW to about 9,000 mW, or from about 8,000 mW to about 9,000 mW.

[0188] In aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity has an average irradiance area of from about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the body area of from about 30 J / cm 2 to about 150 J / cm 2including infrared light such that the total incident energy during a treatment session is from about 0.5 kJ to about 6 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity includes infrared light having a total output over a body area from about 900 mW to about 8,100 mW. In still other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity further includes direct current stimulation therapy to a body area. Both photobiomodulation therapy and direct current stimulation therapy can be administered using the photobiomodulation therapy clothing disclosed herein. In yet other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0189] In aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity has an average irradiance area of from about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the body area of from about 30 J / cm 2 to about 150 J / cm 2including infrared light such that the total incident energy during a treatment session is from about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method for improving cytochrome c oxidase redox activity includes infrared light having a total output over a body area from about 1,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method for improving cytochrome c oxidase redox activity further includes direct current stimulation therapy to a body area. Both photobiomodulation therapy and direct current stimulation therapy can be administered using the clothing for photobiomodulation therapy disclosed herein. In yet other aspects of these embodiments, the disclosed method for improving cytochrome c oxidase redox activity can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0190] In aspects of these embodiments, the disclosed method for improving cytochrome c oxidase redox activity has an average irradiance area of from about 250 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the body area of from about 150 J / cm 2 to about 200 J / cm 2It includes infrared light that is such, the total incident energy during the treatment session is about 4 kJ to about 5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity includes infrared light having a total output across a body region of about 3,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity further includes direct current stimulation therapy for the body region. Both photobiomodulation therapy and direct current stimulation therapy can be administered using the clothing for photobiomodulation therapy disclosed herein. In yet other aspects of these embodiments, the disclosed method of improving cytochrome c oxidase redox activity can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0191] This specification discloses a method of improving the enteric nervous system activity of an individual using photobiomodulation therapy, the method comprising exposing a torso region to infrared light from the clothing for photobiomodulation therapy disclosed herein for one or more treatment sessions. Non-limiting examples of the torso region include the abdominal region, the back region, the shoulder region, or any combination thereof.

[0192] In some embodiments, the disclosed method of improving enteric nervous system activity is, for example, about 10 cm 2 ~ about 25 cm 2 、about 10 cm 2 ~ about 50 cm 2 、about 10 cm 2 ~ about 75 cm 2 、about 10 cm 2 ~ about 100 cm 2 、about 10 cm2 ~ about 125 cm 2 、 about 10 cm 2 ~ about 150 cm 2 、 about 10 cm 2 ~ about 175 cm 2 、 about 10 cm 2 ~ about 200 cm 2 、 about 10 cm 2 ~ about 225 cm 2 、 about 10 cm 2 ~ about 250 cm 2 、 about 10 cm 2 ~ about 275 cm 2 、 about 10 cm 2 ~ about 300 cm 2 、 about 25 cm 2 ~ about 50 cm 2 、 about 25 cm 2 ~ about 75 cm 2 、 about 25 cm 2 ~ about 100 cm 2 、 about 25 cm 2 ~ about 125 cm 2 、 about 25 cm 2 ~ about 150 cm 2 、 about 25 cm 2 ~ about 175 cm 2 、 about 25 cm 2 ~ about 200 cm 2 、 about 25 cm 2 ~ about 225 cm 2 、 about 25 cm 2 ~ about 250 cm 2 、 about 25 cm 2 ~ about 275 cm 2 、 about 25 cm 2 ~ about 300 cm 2 、 about 50 cm 2 ~ about 75 cm 2 、 about 50 cm 2 ~ about 100 cm 2 、 about 50 cm 2 ~ about 125 cm 2 、 about 50 cm 2 ~ about 150 cm 2 、 about 50 cm 2 ~ about 175 cm 2 、 about 50 cm 2 ~ about 200 cm 2 、 about 50 cm 2 ~ about 225 cm 2, about 50 cm 2 ~ about 250 cm 2 , about 50 cm 2 ~ about 275 cm 2 , about 50 cm 2 ~ about 300 cm 2 , about 75 cm 2 ~ about 100 cm 2 , about 75 cm 2 ~ about 125 cm 2 , about 75 cm 2 ~ about 150 cm 2 , about 75 cm 2 ~ about 175 cm 2 , about 75 cm 2 ~ about 200 cm 2 , about 75 cm 2 ~ about 225 cm 2 , about 75 cm 2 ~ about 250 cm 2 , about 75 cm 2 ~ about 275 cm 2 , about 75 cm 2 ~ about 300 cm 2 , about 100 cm 2 ~ about 125 cm 2 , about 100 cm 2 ~ about 150 cm 2 , about 100 cm 2 ~ about 175 cm 2 , about 100 cm 2 ~ about 200 cm 2 , about 100 cm 2 ~ about 225 cm 2 , about 100 cm 2 ~ about 250 cm 2 , about 100 cm 2 ~ about 275 cm 2 , or about 100 cm 2 ~ about 300 cm 2 including exposing a head region including an area of

[0193] In some embodiments, the disclosed methods for improving enteric nervous system activity can include a single treatment session or multiple treatment sessions. In aspects of these embodiments, the disclosed methods for improving enteric nervous system activity can include, for example, about 1 to about 5 treatment sessions, about 1 to about 10 treatment sessions, about 1 to about 15 treatment sessions, about 1 to about 20 treatment sessions, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions. In other aspects of these embodiments, the disclosed methods for improving enteric nervous system activity can include multiple treatment sessions that continue for several months or years.

[0194] In some embodiments, the disclosed methods for improving enteric nervous system activity include exposing the head region to infrared light during a treatment session for, for example, between about 5 minutes and about 10 minutes, about 5 minutes and about 15 minutes, about 5 minutes and about 20 minutes, about 5 minutes and about 25 minutes, about 5 minutes and about 30 minutes, about 5 minutes and about 35 minutes, about 5 minutes and about 40 minutes, about 10 minutes and about 15 minutes, about 10 minutes and about 20 minutes, about 10 minutes and about 25 minutes, about 10 minutes and about 30 minutes, about 10 minutes and about 35 minutes, about 10 minutes and about 40 minutes, about 15 minutes and about 20 minutes, about 15 minutes and about 25 minutes, about 15 minutes and about 30 minutes, about 15 minutes and about 35 minutes, or about 15 minutes and about 40 minutes.

[0195] In some embodiments, the disclosed methods for improving enteric nervous system activity include, for example, about 50 mW / cm 2 ~ about 100 mW / cm 2 、 about 50 mW / cm 2 ~ about 150 mW / cm 2 、 about 50 mW / cm 2 ~ about 200 mW / cm 2 、 about 50 mW / cm 2 ~ about 250 mW / cm 2 、 about 50 mW / cm 2 ~ about 300 mW / cm 2 、 about 100 mW / cm2 ~ about 150 mW / cm 2 、 about 100 mW / cm 2 ~ about 200 mW / cm 2 、 about 100 mW / cm 2 ~ about 250 mW / cm 2 、 about 100 mW / cm 2 ~ about 300 mW / cm 2 、 about 150 mW / cm 2 ~ about 200 mW / cm 2 、 about 150 mW / cm 2 ~ about 250 mW / cm 2 、 about 150 mW / cm 2 ~ about 300 mW / cm 2 、 about 200 mW / cm 2 ~ about 250 mW / cm 2 、 about 200 mW / cm 2 ~ about 300 mW / cm 2 、 or about 250 mW / cm 2 ~ about 300 mW / cm 2 includes infrared light including an average irradiance region of.

[0196] In some embodiments, the disclosed method of improving enteric nervous system activity is, for example, about 30 J / cm 2 ~ about 50 J / cm 2 、 about 30 J / cm 2 ~ about 75 J / cm 2 、 about 30 J / cm 2 ~ about 100 J / cm 2 、 about 30 J / cm 2 ~ about 125 J / cm 2 、 about 30 J / cm 2 ~ about 150 J / cm 2 、 about 50 J / cm 2 ~ about 75 J / cm 2 、 about 50 J / cm 2 ~ about 100 J / cm 2 、 about 50 J / cm 2 ~ about 125 J / cm 2 、 about 50 J / cm 2 ~ about 150 J / cm 2 、 about 75 J / cm 2 ~ about 100 J / cm 2 、 about 75 J / cm 2 ~ about 125 J / cm2 , about 75 J / cm 2 to about 150 J / cm 2 , about 100 J / cm 2 to about 125 J / cm 2 , about 100 J / cm 2 to about 150 J / cm 2 , or about 100 J / cm 2 to about 150 J / cm 2 and includes infrared light having an average fluence over a body region of about 100 J / cm

[0197] In some embodiments, the disclosed method of improving enteric nervous system activity involves infrared light having a total incident energy during a treatment session of, for example, from about 0.5 kJ to about 1.0 kJ, from about 0.5 kJ to about 1.5 kJ, from about 0.5 kJ to about 2.0 kJ, from about 0.5 kJ to about 2.5 kJ, from about 0.5 kJ to about 3.0 kJ, from about 0.5 kJ to about 3.5 kJ, from about 0.5 kJ to about 4.0 kJ, from about 0.5 kJ to about 4.5 kJ, from about 0.5 kJ to about 5.0 kJ, from about 0.5 kJ to about 5.5 kJ, from about 0.5 kJ to about 6 kJ, from about 1.0 kJ to about 1.5 kJ, from about 1.0 kJ to about 2.0 kJ, from about 1.0 kJ to about 2.5 kJ, from about 1.0 kJ to about 3.0 kJ, from about 1.0 kJ to about 3.5 kJ, from about 1.0 kJ to about 4.0 kJ, from about 1.0 kJ to about 4.5 kJ, from about 1.0 kJ to about 5.0 kJ, from about 1.0 kJ to about 5.5 kJ, from about 1.0 kJ to about 6 kJ, from about 1.5 kJ to about 2.0 kJ, from about 1.5 kJ to about 2.5 kJ, from about 1.5 kJ to about 3.0 kJ, from about 1.5 kJ to about 3.5 kJ, from about 1.5 kJ to about 4.0 kJ, from about 1.5 kJ to about 4.5 kJ, from about 1.5 kJ to about 5.0 kJ, from about 1.5 kJ to about 5.5 kJ, from about 1.5 kJ to about 6 kJ, from about 2.0 kJ to about 2.5 kJ, from about 2.0 kJ to about 3.0 kJ, from about 2.0 kJ to about 3.5 kJ, from about 2.0 kJ to about 4.0 kJ, from about 2.0 kJ to about 4.5 kJ, from about 2.0 kJ to about 5.0 kJ, from about 2.0 kJ to about 5.5 kJ, from about 2.0 kJ to about 6 kJ, from about 2.5 kJ to about 3.0 kJ, from about 2.5 kJ to about 3.5 kJ, from about 2.5 kJ to about 4.0 kJ, from about 2.5 kJ to about 4.5 kJ, from about 2.5 kJ to about 5.0 kJ, from about 2.5 kJ to about 5.5 kJ, from about 2.5 kJ to about 6 kJ, from about 3.0 kJ to about 3.5 kJ, from about 3.0 kJ to about 4.0 kJ, from about 3.0 kJ to about 4.5 kJ, from about 3.0 kJ to about 5.0 kJ, from about 3.0 kJ to about 5.5 kJ, from about 3.0 kJ to about 6 kJ, from about 3.5 kJ to about 4.0 kJ, from about 3.5 kJ to about 4.5 kJ, from about 3.5 kJ to about 5.0 kJ, from about 3.5 kJ to about 5.5 kJ, from about 3.5 kJ to about 6 kJ, from about 4.0 kJ to about 4.5 kJ, from about 4.0 kJ to about 5.0 kJ, from about 4.0 kJ to about 5.5 kJ, from about 4.0 kJ to about 6 kJ, from about 4.5 kJ to about 5.0 kJ, from about 4.5 kJ to about 5.5 kJ, from about 4.5 kJ to about 6 kJ, from about 5.0 kJ to about 5.5 kJ, from about 5.0 kJ to about 6 kJ, or from about 5.5 kJ to about 6 kJ.

[0198] In some embodiments, the disclosed method of improving enteric nervous system activity includes infrared light having a total output over a body area of, for example, about 1,000 mW to about 2,000 mW, about 1,000 mW to about 3,000 mW, about 1,000 mW to about 4,000 mW, about 1,000 mW to about 5,000 mW, about 1,000 mW to about 6,000 mW, about 1,000 mW to about 7,000 mW, about 1,000 mW to about 8,000 mW, about 1,000 mW to about 9,000 mW, about 2,000 mW to about 3,000 mW, about 2,000 mW to about 4,000 mW, about 2,000 mW to about 5,000 mW, about 2,000 mW to about 6,000 mW, about 2,000 mW to about 7,000 mW, about 2,000 mW to about 8,000 mW, about 2,000 mW to about 9,000 mW, about 3,000 mW to about 4,000 mW, about 3,000 mW to about 5,000 mW, about 3,000 mW to about 6,000 mW, about 3,000 mW to about 7,000 mW, about 3,000 mW to about 8,000 mW, about 3,000 mW to about 9,000 mW, about 4,000 mW to about 5,000 mW, about 4,000 mW to about 6,000 mW, about 4,000 mW to about 7,000 mW, about 4,000 mW to about 8,000 mW, about 4,000 mW to about 9,000 mW, about 5,000 mW to about 6,000 mW, about 5,000 mW to about 7,000 mW, about 5,000 mW to about 8,000 mW, about 5,000 mW to about 9,000 mW, about 6,000 mW to about 7,000 mW, about 6,000 mW to about 8,000 mW, about 6,000 mW to about 9,000 mW, about 7,000 mW to about 8,000 mW, about 7,000 mW to about 9,000 mW, or about 8,000 mW to about 9,000 mW.

[0199] In other aspects of these embodiments, the disclosed method of improving enteric nervous system activity is an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the torso area of about 30 J / cm 2 to about 150 J / cm 2including infrared light such that the total incident energy during a treatment session is from about 0.5 kJ to about 6 kJ, or any combination thereof. In yet other aspects of these embodiments, the disclosed method of improving enteric nervous system activity includes infrared light having a total output over a body region from about 900 mW to about 8,100 mW. In still other aspects of these embodiments, the disclosed method of improving enteric nervous system activity further includes direct current stimulation therapy to a body region. Both the photobiomodulation therapy and the direct current stimulation therapy can be administered using the photobiomodulation therapy clothing disclosed herein. In other aspects of these embodiments, the disclosed method of improving enteric nervous system activity can include a single treatment session, or multiple treatment sessions such as, for example, from about 2 to about 5 treatment sessions, from about 2 to about 10 treatment sessions, from about 2 to about 15 treatment sessions, from about 2 to about 20 treatment sessions, from about 5 to about 10 treatment sessions, from about 5 to about 15 treatment sessions, from about 5 to about 20 treatment sessions, from about 10 to about 15 treatment sessions, from about 10 to about 20 treatment sessions, or from about 15 to about 20 treatment sessions.

[0200] In aspects of these embodiments, the disclosed method of improving enteric nervous system activity includes an average irradiance area from about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over a body region from about 30 J / cm 2 to about 150 J / cm 2It includes infrared light that is such and has a total incident energy during the treatment session of about 1.5 kJ to about 3.5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving enteric nervous system activity includes infrared light having a total output across the body region of about 1,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method of improving enteric nervous system activity further includes direct current stimulation therapy for the body region. Both photobiomodulation therapy and direct current stimulation therapy can be administered using the clothing for photobiomodulation therapy disclosed herein. In still other aspects of these embodiments, the disclosed method of improving enteric nervous system activity can include a single treatment session or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0201] In aspects of these embodiments, the disclosed method of improving enteric nervous system activity is about 250 mW / cm 2 ~ about 300 mW / cm 2 of the average irradiance area, and the average fluence across the body region is about 150 J / cm 2 ~ about 200 J / cm 2It includes infrared light including being such, the total incident energy during the treatment session being about 4 kJ to about 5 kJ, or any combination thereof. In other aspects of these embodiments, the disclosed method of improving enteric nervous system activity includes infrared light including a total output across the torso region of about 3,000 mW to about 8,400 mW. In still other aspects of these embodiments, the disclosed method of improving enteric nervous system activity further includes direct current stimulation therapy for the torso region. Both the photobiomodulation therapy and the direct current stimulation therapy can be administered using the clothing for photobiomodulation therapy disclosed herein. In yet other aspects of these embodiments, the disclosed method of improving enteric nervous system activity can include a single treatment session, or multiple treatment sessions such as, for example, about 2 to about 5 treatment sessions, about 2 to about 10 treatment sessions, about 2 to about 15 treatment sessions, about 2 to about 20 treatment sessions, about 5 to about 10 treatment sessions, about 5 to about 15 treatment sessions, about 5 to about 20 treatment sessions, about 10 to about 15 treatment sessions, about 10 to about 20 treatment sessions, or about 15 to about 20 treatment sessions.

[0202] In some embodiments, the clothing for photobiomodulation therapy disclosed herein is used as the sole treatment device. In some embodiments, the clothing for photobiomodulation therapy disclosed herein is used in combination with another therapy. In some embodiments, the clothing for photobiomodulation therapy disclosed herein is used in combination with another cognitive behavioral therapy.

[0203] In some embodiments, the clothing for photobiomodulation therapy disclosed herein is used in combination with another photobiomodulation therapy such as, for example, photobiomodulation therapy with a high output irradiance. In some embodiments, an individual uses the clothing for photobiomodulation therapy disclosed herein capable of delivering the following irradiance in combination with low output transcranial photobiomodulation therapy 2 with about 250 mW / cm2 Receive high - power transcranial photobiomodulation therapy using a fixed device capable of applying the above irradiance. In some embodiments, the high - power photobiomodulation therapy is performed in a clinical or other medical facility environment, while the low - power photobiomodulation therapy is performed in a non - clinical environment such as at home, in a park, or while driving in a vehicle. In some embodiments, the low - power transcranial photobiomodulation therapy is used to enhance the effectiveness of the high - power transcranial photobiomodulation therapy and improve the treatment of an individual's depression and depressive symptoms. In some embodiments, the circadian - based timing therapy disclosed herein is used to time the high - power transcranial photobiomodulation therapy, the low - power transcranial photobiomodulation therapy, or both.

[0204] In some embodiments, the photobiomodulation therapy clothing disclosed herein is used in combination with transcranial magnetic stimulation (TMS). In some embodiments, an individual receives TMS in combination with low - power transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein that is capable of applying an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 , an average fluence across the head area of about 30 J / cm 2 to about 150 J / cm 2 , a total incident energy during the treatment session of about 0.5 kJ to about 6 kJ, a total output across the head area of about 900 mW to about 8,100 mW, or any combination thereof. In some embodiments, an individual receives TMS in combination with low - power transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein that is capable of applying an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 , an average fluence across the head area of about 30 J / cm 2 to about 150 J / cm 2being, the total incident energy during the treatment session being from about 1.5 kJ to about 3.5 kJ, the total output over the head region being from about 1,000 mW to about 8,400 mW, or any combination thereof, and receiving TMS in combination with a low-output transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein. In some embodiments, the individual has an average irradiance area of about 250 mW / cm 2 to about 300 mW / cm 2 and the average fluence over the head region is about 150 J / cm 2 to about 200 J / cm 2 being, the total incident energy during the treatment session being from about 4 kJ to about 5 kJ, the total output over the head region being from about 3,000 mW to about 8,400 mW, or any combination thereof, and receiving TMS in combination with a low-output transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein. In some embodiments, TMS is performed in a clinical or other medical facility setting, while the low-output photobiomodulation therapy is performed in a non-clinical setting such as at home, in a park, or while driving in a vehicle. In some embodiments, the low-output transcranial photobiomodulation therapy is used to enhance the effectiveness of TMS and improve the treatment of the individual's depression and depressive symptoms. In some embodiments, the circadian-based timing therapy disclosed herein is used to time TMS, low-output transcranial photobiomodulation therapy, or both.

[0205] In some embodiments, the photobiomodulation therapy clothing disclosed herein is used in conjunction with evidence-based mental health practices. In some embodiments, the individual has an average irradiance area of about 55 mW / cm 2Receive evidence-based mental health practices in conjunction with low-level transcranial photobiomodulation therapy using the clothing for photobiomodulation therapy disclosed herein that is capable of delivering the following irradiance. Evidence-based mental health practices include, but are not limited to, Evidence Based Psychotherapy (EBT), Cognitive Behavioral Therapy (CBT), Dialectical Behavioral Therapy (DBT), exposure therapy, Functional Family Therapy (FFT), Assertive Community Treatment (ACT), Acceptance and Commitment Therapy (ACT), Prolonged Exposure (PE), cognitive training and rehabilitation, and Motivational Interviewing (MI). In some embodiments, evidence-based mental health practices are performed by a therapist in a clinical or other healthcare facility setting, while low-level photobiomodulation therapy is performed in a non-clinical environment such as at home, in a park, or while driving in a vehicle. In some embodiments, evidence-based mental health practices are performed by a therapist in a virtual environment, while low-level photobiomodulation therapy is performed in a non-clinical environment such as at home, in a park, or while driving in a vehicle. In some embodiments, evidence-based mental health practices are digital-based artificial intelligence (AI) therapies, while low-level photobiomodulation therapy is performed in a non-clinical environment such as at home, in a park, or while driving in a vehicle. In some embodiments, low-level transcranial photobiomodulation therapy is used to enhance the effectiveness of evidence-based mental health practices and improve the treatment of an individual's depression and depressive symptoms.In some embodiments, the circadian-based timing therapy disclosed herein is used to time evidence-based mental health practice, low-level transcranial photobiomodulation therapy, or both.

[0206] In some embodiments, the photobiomodulation therapy clothing disclosed herein is used in conjunction with eye phototherapy such as, for example, high-intensity light therapy or blue light therapy. In some embodiments, an individual receives eye phototherapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein capable of delivering an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 , an average fluence across the head area of about 30 J / cm 2 to about 150 J / cm 2 , a total incident energy during a treatment session of about 0.5 kJ to about 6 kJ, a total output across the head area of about 900 mW to about 8,100 mW, or any combination thereof. In some embodiments, an individual receives eye phototherapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein capable of delivering an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 , an average fluence across the head area of about 30 J / cm 2 to about 150 J / cm 2 , a total incident energy during a treatment session of about 1.5 kJ to about 3.5 kJ, a total output across the head area of about 1,000 mW to about 8,400 mW, or any combination thereof. In some embodiments, an individual receives eye phototherapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein capable of delivering an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 , an average fluence across the head area of about 30 J / cm 2 to about 150 J / cm 2That is, the total incident energy during the treatment session is about 0.5 kJ to about 6 kJ, the total output over the head region is about 900 mW to about 8,100 mW, or any combination thereof, and receive ocular phototherapy in combination with transcranial photobiomodulation therapy using the clothing for photobiomodulation therapy disclosed herein. In some embodiments, the transcranial photobiomodulation therapy can be administered daily during and / or between each of two or more ocular phototherapy sessions. In some embodiments, the transcranial photobiomodulation therapy is used to enhance the effectiveness of ocular phototherapy by enhancing relaxation, sedation, and well-being. In some embodiments, the circadian-based timing therapy disclosed herein is used to time the administration of ocular phototherapy, transcranial photobiomodulation therapy, or both.

[0207] In some embodiments, the clothing for photobiomodulation therapy disclosed herein is used in combination with mindfulness therapy. In some embodiments, the individual practices mindfulness therapy in combination with transcranial photobiomodulation therapy using the clothing for photobiomodulation therapy disclosed herein, which is capable of delivering an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the head region of about 30 J / cm 2 to about 150 J / cm 2 ; the total incident energy during the treatment session is about 0.5 kJ to about 6 kJ; the total output over the head region is about 900 mW to about 8,100 mW; or any combination thereof. In some embodiments, the individual practices mindfulness therapy in combination with transcranial photobiomodulation therapy using the clothing for photobiomodulation therapy disclosed herein, which is capable of delivering an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the head region of about 30 J / cm 2 to about 150 J / cm 2to be such that the total incident energy during the treatment session is from about 1.5 kJ to about 3.5 kJ, the total output over the head region is from about 1,000 mW to about 8,400 mW, or any combination thereof, and practice mindfulness therapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein. In some embodiments, the individual has an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the head region of about 30 J / cm 2 to about 150 J / cm 2 to be such that the total incident energy during the treatment session is from about 0.5 kJ to about 6 kJ, the total output over the head region is from about 900 mW to about 8,100 mW, or any combination thereof, and practice mindfulness therapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein. In some embodiments, transcranial photobiomodulation therapy can be administered daily during mindfulness therapy and / or between each of two or more mindfulness therapy sessions. In some embodiments, transcranial photobiomodulation therapy is used to enhance the effectiveness of mindfulness therapy by enhancing relaxation, sedation, and well-being. In some embodiments, the circadian-based timing therapy disclosed herein is used to time the administration of mindfulness therapy, transcranial photobiomodulation therapy, or both.

[0208] In some embodiments, the photobiomodulation therapy clothing disclosed herein is used in conjunction with meditation therapy. In some embodiments, the individual has an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 and an average fluence over the head region of about 30 J / cm 2 to about 150 J / cm 2That the total incident energy during a treatment session is from about 0.5 kJ to about 6 kJ, the total output over the head region is from about 900 mW to about 8,100 mW, or any combination thereof, practicing meditation therapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein that is capable of delivering such. In some embodiments, the individual is exposed to an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 and the average fluence over the head region is from about 30 J / cm 2 to about 150 J / cm 2 That the total incident energy during a treatment session is from about 1.5 kJ to about 3.5 kJ, the total output over the head region is from about 1,000 mW to about 8,400 mW, or any combination thereof, practicing meditation therapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein that is capable of delivering such. In some embodiments, the individual is exposed to an average irradiance area of about 50 mW / cm 2 to about 300 mW / cm 2 and the average fluence over the head region is from about 30 J / cm 2 to about 150 J / cm 2 That the total incident energy during a treatment session is from about 0.5 kJ to about 6 kJ, the total output over the head region is from about 900 mW to about 8,100 mW, or any combination thereof, practicing meditation therapy in conjunction with transcranial photobiomodulation therapy using the photobiomodulation therapy clothing disclosed herein that is capable of delivering such. In some embodiments, transcranial photobiomodulation therapy can be administered daily during meditation therapy and / or between each of two or more meditation therapies. In some embodiments, transcranial photobiomodulation therapy is used to enhance the effectiveness of meditation therapy by enhancing relaxation, sedation, and well-being. In some embodiments, the daily-based timing therapy disclosed herein is used to time the administration of meditation therapy, transcranial photobiomodulation therapy, or both.

[0209] In some embodiments, the photobiomodulation therapy using the clothing for photobiomodulation therapy disclosed herein is administered based on an individual's circadian rhythm, either alone or in combination with another therapy. In some embodiments, the individual receives transcranial photobiomodulation therapy using the clothing for photobiomodulation therapy disclosed herein during a morning time period, such as from 6:00 a.m. to 10:00 a.m. In some embodiments, the individual receives trans...

Claims

1. Clothing for photobiomodulation therapy, A garment configured to be worn by a user over the surface of the skin, wherein the garment comprises a first surface and a second surface opposite to the first surface, the first surface being configured to face the surface of the skin when the garment is worn, A photobiomodulation unit integrated within the garment, comprising a connection terminal, one or more near-infrared light sources, and one or more sensors, wherein the connection terminal communicates electronically with the one or more near-infrared light sources and the one or more sensors, and the one or more near-infrared light sources are low-level lasers, each configured to emit near-infrared light with a wavelength of 800 nm to 1200 nm and a predetermined dose measurement value, A controller comprising a processor and memory, wherein the controller is configured to operably engage with the terminal rail of the connection terminal to establish electronic communication between the controller and the connection terminal, and Equipped with, The first surface of the garment includes a first portion having one or more light apertures, and each of the one or more near-infrared light sources is operably aligned with the one or more light apertures to allow proper passage of near-infrared light from the one or more near-infrared light sources through the one or more light apertures. The first surface of the garment includes a second portion having one or more sensor openings, each of the one or more sensors being operably aligned with the one or more sensor openings to enable proper functioning of the one or more sensors through the one or more sensor openings, The processor and the memory are comprised of executable instructions for individually controlling each of the one or more near-infrared light sources and each of the one or more sensors. Clothing for photobiomodulation therapy.

2. The garment for photobiomodulation therapy according to claim 1, wherein the garment is configured to wrap around or conform to a body part, while having the function of being moved from one body part area to another body part area.

3. The garment for photobiomodulation therapy according to claim 1, wherein the garment is sized and has dimensions to fit particularly well to a specific part of the body.

4. The photobiomodulation therapy garment according to claim 3, wherein the specific body part is the head region, neck region, shoulder region, torso region, hand region, wrist region, arm region, foot region, or leg region, or any combination thereof.

5. The photobiomodulation therapy garment according to claim 4, wherein the garment is a headband, hat, visor, shirt, pants, socks, gloves, or underwear.

6. The photobiomodulation therapy garment according to claim 1, wherein each of the one or more sensors is configured to detect and collect information relating to one or more parameters of the garment, the photobiomodulation unit and its components, the controller and its components, and the user, and then transmit the information to the controller.

7. The photobiomodulation therapy garment according to claim 6, wherein the one or more parameters include operational information of the garment, the photobiomodulation unit and its components, and the controller and its components, biological information relating to the user, or any combination thereof.

8. The garment for photobiomodulation therapy according to claim 1, wherein the executable command controls each of the one or more near-infrared light sources individually.

9. The photobiomodulation therapy garment according to claim 8, wherein the executable command controls, with respect to each of the one or more near-infrared light sources, operation, duration of operation, stop, duration of stop, pattern and timing of operation, pattern and timing of stop, fluence level, irradiance level, dose measurement level, pulse operation, continuous operation, operation time, cycle duration, or any combination thereof.

10. The garment for photobiomodulation therapy according to claim 1, wherein the executable command controls each of the one or more sensors individually.

11. The garment for photobiomodulation therapy according to claim 10, wherein the executable command controls the collection and analysis of information obtained from each of the one or more sensors.

12. The photobiomodulation therapy garment according to claim 1, wherein the one or more near-infrared light sources are a plurality of spaced-apart near-infrared light sources.

13. The garment for photobiomodulation therapy according to claim 12, wherein the plurality of near-infrared light sources are arranged in a plurality of spaced-apart near-infrared light source groups, and each of the plurality of near-infrared light source groups comprises a subset of the one or more near-infrared light sources.

14. The photobiomodulation therapy garment according to claim 1, further comprising one or more stimulating devices.

15. The photobiomodulation therapy garment according to claim 14, wherein the one or more stimulators include a component capable of generating a direct current or a magnetic field.

16. The photobiomodulation therapy garment according to claim 15, wherein the one or more stimulators that generate direct current are transcranial direct current stimulators.

17. The photobiomodulation therapy garment according to claim 1, wherein the processor and the memory are comprised of executable instructions for dynamically controlling each of the one or more near-infrared light sources and each of the one or more sensors.

18. The photobiomodulation therapy garment according to claim 1, wherein the skin surface includes a forehead area, a neck area garment, a posterior neck area garment, a shoulder area area garment, a wrist area area garment, an abdominal area area garment, a back area area garment, or any combination thereof.

19. The photobiomodulation therapy garment according to claim 18, wherein the forehead area includes the dorsolateral prefrontal cortex region, the frontal eye field region, or both.

20. Each of the one or more near-infrared light sources is configured to emit near-infrared light with a wavelength of 700 nm to 1200 nm or 800 nm to 1100 nm; or Each of the one or more near-infrared light sources is configured to emit an irradiance of at least 50 mW / cm² to a maximum of 40 mW / cm²; or The one or more near-infrared light sources are configured to emit a radiant flux of at least 3,000 mW; Clothing for photobiomodulation therapy according to claim 1.

21. A photobiomodulation therapy garment according to any one of claims 1 to 20, for use in providing photobiomodulation therapy.

22. The photobiomodulation therapy garment according to claim 21, wherein the photobiomodulation therapy is transcranial photobiomodulation therapy.

23. The photobiomodulation therapy garment according to claim 21, wherein the photobiomodulation therapy garment is the sole treatment device, or the photobiomodulation therapy garment is used in conjunction with another therapy.

24. The photobiomodulation therapy garment according to claim 23, wherein the other therapy is high-intensity irradiance photobiomodulation therapy, cognitive behavioral therapy, transcranial magnetic stimulation, ocular phototherapy, evidence-based mental health practices, mindfulness therapy, or meditation therapy.

25. The photobiomodulation therapy is administered as follows: To increase cellular energy production; Increase the mitochondrial energy of neurons; Increases adenosine triphosphate (ATP) production; Increases the production of reactive oxygen species; Reduce inflammation at the cellular and tissue levels; To improve cell repair and healing; Increases nitric oxide production; Increase cerebral blood flow; Increases neurogenesis; Increases neural plasticity; Increase neuroprotection; Enhances nerve repair; Reduce inflammation; or Any combination of these; Clothing for photobiomodulation therapy according to claim 21.

26. The use of the photobiomodulation therapy garment brings at least 500 J of radiant energy during the therapy; or The use of the photobiomodulation therapy garment results in radiation exposure of at least 30 J / cm² to a maximum of 200 J / cm² during the therapy; or The use of the aforementioned photobiomodulation therapy garment results in a radiation intensity of at least 30 mW / cm² to a maximum of 400 mW / cm² during the therapy; Clothing for photobiomodulation therapy according to claim 21.

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