Imidazopyridine compounds, preparations thereof and their therapeutic use

Abstract

Compounds capable of inhibiting ERK5 are provided. Pharmaceutical compositions and their medical uses, including uses for treating or preventing conditions such as cancer, are also provided.

Description

Technical Field

[0001] Compounds capable of inhibiting ERK5 are provided. Pharmaceutical compositions and their medical uses are also provided, including uses for treating or preventing conditions such as cancer.

Background Art

[0002] The mitogen-activated protein kinase (MAPK) cascade is a highly conserved cellular pathway that transmits signals from the cell surface to the nucleus. This pathway plays an important role in cell proliferation, differentiation, and migration and is known to be involved in the development of cancer. The proteins in the pathway include extracellular signal-regulated kinase (ERK) proteins, among which ERK5 (expressed from the MAPK7 gene) plays an important role in cell proliferation and in epithelial development and neural differentiation (see, for example, Nishimoto et al., EMBO Reports (2006) 7(8):782-786). ERK5 is unique among ERK proteins in having a large C-terminal domain that includes a transcriptional activation domain (TAD), as well as a nuclear localization signal and two proline-rich regions (see, for example, Guo et al., Exp Ther Med. (2020) 19:1997-2007). Autophosphorylation of the TAD is required for transcriptional activation (see, for example, Morimoto et al., J Biol Chem. (2007) 282(49):35449-35456).

[0003] ERK5 plays an important role in the regulation of cell proliferation and cell cycle progression, for example, through the direct or indirect phosphorylation of, among others, MEF2C, cMYC, SGK1, RSK, FOS and FRA1 (see, for example, Paudel et al., Int J Mol Sci. (2021) 22:7594-7614; Terasawa et al., Genes to Cells (2003) 8(3):263-273). The involvement of ERK5 in many biological pathways means that its activity is associated with many aspects of cancer progression, including tumor angiogenesis, metastasis, inflammation, sustained proliferation and avoidance of growth suppression. Therefore, it presents an attractive target for modulating disease pathology and treatment under a wide range of conditions. Previous studies have shown that ERK5 inhibition or downregulation, among other things, blocks tumor formation in mouse leukemia cells, reduces the proliferation of chronic myeloid leukemia cells, inhibits the proliferation of breast cancer and multiple myeloma cells, suppresses colon cancer cell proliferation, and is required to affect the proliferation or survival of renal cell carcinoma, mesothelioma, adenocarcinoma, neuroblastoma and hepatocellular carcinoma cells (see, for example, Stecca et al., Int J Mol Sci. (2019) 20:1426-1446).

[0004] Therefore, ERK5 inhibition represents a promising approach for addressing a wide range of cancers. Several ERK5 inhibitors have been developed, and some are under clinical review. For example, International Publication No. WO 2019 / 170543 pamphlet (Bayer AG and Bayer Pharma AG) discloses compounds that are said to be active as ERK5 inhibitors in the concentration range of μM to nM. In particular, ERK5 inhibition has been reported to have potential use in the treatment of melanoma in combination with BRAF-MEK1 / 2-ERK1 / 2 pathway inhibitors in order to overcome intrinsic resistance and inhibit or delay some modes of acquired resistance (see, for example, Cook et al., Front. Cell Dev. Biol. (2022)). SUMMARY OF THE INVENTION PROBLEMS TO BE SOLVED BY THE INVENTION

[0005] Despite recent advances in cancer treatment through the development of targeted chemotherapy and immunotherapy, not all cancer patients can be provided with an efficient treatment solution. Therefore, there is a need to identify and develop new drugs. The present disclosure aims to address this need by providing novel compounds for use as ERK5 inhibitors and novel compounds for the treatment of ERK5-related diseases and conditions.

Means for Solving the Problems

[0006] Accordingly, a first aspect provides a compound of formula (I)

Chemical formula

[0007] In an embodiment, the compound is of formula (I-A)

Chemical formula

[0008] In an embodiment, the compound is of formula (I-B)

Chemical formula

[0009] In an embodiment, the compound is as defined above, wherein R 1 is selected from -H, -(C1-C6)alkyl, -(C3-C7)cycloalkyl, -(C4-C8)cycloalkenyl, -(C6-C 10 )aryl, 4-10 membered heterocycloalkyl, 5-8 membered heterocycloalkenyl, and 5-10 membered heteroaryl, and R 1 is optionally substituted in one or more occurrences of R A , each R Ais independently selected from halo, -OH, -NHR’, -CN, oxo, -SO2CH3, -(C1-C3)alkyl, -O(C1-C3)alkyl, -C(O)R’’, -C(O)NHR’, -NHC(O)R’’, -(C3-C6)cycloalkyl, 3- to 6-membered heterocycloalkyl, phenyl, and pyridyl, and each occurrence of -(C1-C3)alkyl, -O(C1-C3)alkyl, and phenyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH2, and -CN, and / or R A wherein two occurrences of R are optionally joined together with the atoms to which they are attached to form a (C3-C6)cycloalkyl group or a 3- to 6-membered heterocycloalkyl group, each R’ is independently selected from -H, methyl, and phenyl, each R’’ is independently selected from methyl, phenyl optionally substituted with -OCF3, and tetrahydrofuranyl, R 2 is selected from -(C3-C6)cycloalkyl, 5- to 10-membered heterocycloalkyl, -(C6-C 10 )aryl, and 5- to 10-membered heteroaryl, and R 2 is optionally substituted in one or more occurrences of R B , each R B is selected from halo, -OH, -NH2, -NO2, -CN, -SF5, -B(OH)2, -(C1-C3)alkyl, -O(C1-C3)alkyl, -(C3-C6)cycloalkyl, -SO2CH3, phenyl, benzyl, 1-λ 6 -2-thiazolidine-1,1-dionyl and pyridyl, and each occurrence of -(C1-C3)alkyl, -O(C1-C3)alkyl, -(C3-C6)cycloalkyl, phenyl, and benzyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH2, and -CF3, Further, when R 2 is -(C3-C6)cycloalkyl, R 2 is optionally substituted at one ring atom by a spirocyclic oxindolyl group, X and Y are each independently selected from CH and N (provided that when Y is N, X is also N).

[0010] In embodiments, the compound is a compound of formula (I-C) or formula (I-D)

Chemical formula

[0011] In embodiments, R 2 is selected from -(C3-C6) cycloalkyl, 5-6 membered heterocycloalkyl, 9-10 membered heterocycloalkyl, -(C6-C 10 ) aryl, 5-6 membered heteroaryl, and 9-10 membered heteroaryl, and R 2 is optionally substituted at one or more occurrences of R B as defined previously.

[0012] In embodiments, R 2 is

Chemical formula

[0013] In embodiments, R 2 is

Chemical formula

[0014] In embodiments, R B at least one occurrence of is -SF5.

[0015] In embodiments, R 2 is

Chemical formula

[0016] In embodiments, R 1 is -H, -(C1-C3)alkyl, -(C3-C6)cycloalkyl, -(C5-C7)cycloalkenyl, -(C6-C 10 )aryl, 4-9 membered heterocycloalkyl, 6 membered heterocycloalkenyl, 5-6 membered heteroaryl, and 9-10 membered heteroaryl, and R 1 is optionally substituted at one or more occurrences of R A as defined previously.

[0017] In embodiments, R 1 is

Chemical formula

[0018] In embodiments, R 1 is

Chemical formula

[0019] In embodiments, R 1 is -(C4 - C8)cycloalkenyl, -(C6 - C 10 )aryl, 7 - 10 - membered polycyclic (e.g., bicyclic) heterocycloalkyl, 5 - 8 - membered heterocycloalkenyl, and 7 - 10 - membered polycyclic (e.g., bicyclic) heteroaryl, R 1 is optionally substituted by one or more occurrences of R as defined above, or R A is -(C1 - C6)alkyl substituted by one or more substituents selected from - OH, - NH2, and - O(C1 - C3)alkyl. 1

[0020] In embodiments, L 1 is a direct bond or - CH2-.

[0021] Another aspect provides a compound of formula (II)

Chemical formula

[0022] A further aspect provides a compound of formula (III)

Chemical formula

[0023] A further aspect provides a compound of formula (IV)

Chemical formula

[0024] A further aspect provides a compound of formula (V)

Chemical formula

[0025] In an embodiment, R B2 is -SF5.

[0026] A further aspect is a compound of formula (VIII), (IX), or (X)

Chemical formula

[0027] A further aspect is -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(4-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -trans-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -cis-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -cis-[4-[2-(4-Aminocyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -1-[3-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]azetidin-1-yl]ethanone, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-methyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -5-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one, -[4-(trifluoromethoxy)phenyl]-[4-[2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-(3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(oxetan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2,2-dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(Azetidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(1-Methylpyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(6,6-dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(2,2-Dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(6,6-Dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(1,4-Dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(4-Methylmorpholin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(5,5-difluoropiperidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1-(2,2-difluoroethyl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-[1-(2,2-difluoroethyl)azetidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(oxetan-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(4-Chloro-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[2-Nitro-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(2-Oxaspiro[3.3]heptan-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(1,1,2,2,2-Pentafluoroethyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-(Pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(cis)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)cyclohexyl]methanone, -(trans)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)cyclohexyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-oxaspiro[3.3]heptan-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxetan-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(4-Methoxy-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -6-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-3-(trifluoromethyl)-1H-pyridin-2-one, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)phenyl]methanone, -[4-(Trifluoromethoxy)phenyl]-[4-[2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, --[4-(2-Tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, --[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(3-Methoxy-1-bicyclo[1.1.1]pentanyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]methanone, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]methanone, -[4-[2-(5,5-Difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydropyran-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-(2-Pyrrolidin-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-[(1-Methyl-4-piperidyl)methyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(Tetrahydropyran-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, and -[4-[2-[1-(2,2-Difluoroethyl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, A compound selected from the group consisting of and a pharmaceutically acceptable salt thereof are provided.

[0028] A further aspect is -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxetan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[Tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[Pyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -2-Naphthyl-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -1H-Indazol-3-yl-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]methanone; -(1-Methyl-5-phenyl-pyrazol-3-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(3-Amino-2-naphthyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(2-Amino-3,4,5,6-tetrafluoro-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[1-Isopropyl-2-(trifluoromethyl)benzimidazol-5-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(2-Amino-4-methylsulfonyl-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[3-(1,1-Dioxo-1,2-thiazolidin-2-yl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-(3-Hydroxyphenyl)cyclopropyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -2-[2-Chloro-4-(trifluoromethyl)phenoxy]-1-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]propan-1-one; -(3-Phenylcyclopentyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-Hydroxy-1-[2-(trifluoromethyl)phenyl]pyrazol-3-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[5,5-Difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[3-Amino-4-phenyl-5-(trifluoromethyl)-2-thienyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(7-Hydroxy-1H-indol-2-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(1-Cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -1-[4-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1-piperidyl]ethanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)cyclohexyl]methanone; -1-[4-[7-[1-[2-Amino-4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1-piperidyl]ethanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-Cyclohexyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1,4-dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -2-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]benzothiophene-5-carbonitrile; -(5-Amino-1-phenyl-pyrazol-4-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -2-[2-Oxo-2-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]ethyl]-4H-1,4-benzoxazin-3-one; -1-(3,4-Difluorophenyl)-4-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]pyrrolidin-2-one; -[4-(3-Chloro-4-fluoro-phenyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(7-Amino-2-methyl-pyrazolo[1,5-a]pyrimidin-6-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -1-[(2-Chlorophenyl)methyl]-4-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]pyrrolidin-2-one; -1-(4-Fluorophenyl)-4-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]pyrrolidin-2-one; -[1-[(2-Chlorophenyl)methyl]pyrazol-4-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Aminophenyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(3,6-Dichloroimidazo[1,2-a]pyridin-2-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(4-Amino-1-ethyl-pyrazol-3-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(3-Aminoquinoxalin-2-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -2-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]spiro[cyclopropane-1,3'-indoline]-2'-one; -[1-(2-Chlorophenyl)pyrrolidin-3-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(2-Amino-4,5-dichloro-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[1-(4-Fluorophenyl)imidazol-4-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-hydroxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-cyclohexyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxypropyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(3-Amino-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Amino-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -(trans)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)cyclohexyl]methanone; -[3-Fluoro-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(4-Methylpiperazin-1-yl)methyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[2-(5-Chloro-2-hydroxy-phenyl)thiazol-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-Fluoro-5-hydroxy-phenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -N-[3-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]phenyl]tetrahydrofuran-2-carboxamide; -[4-[2-[5-(Hydroxymethyl)isoxazol-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -1-Ethyl-3-hydroxy-6-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]quinoxalin-2-one; -[3-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -(4-Bromophenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1,4-dioxan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -4-[7-[1-[2-Amino-4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]cyclohexanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-(4-trimethylsilylphenyl)methanone; -(cis)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(trans)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(2,2-Difluoro-1,3-benzodioxol-5-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(4-Bromo-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-(trifluoromethyl)-1H-indol-6-yl]methanone; -[4-(Cyclopropoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[5,5-difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -2-Tetrahydropyran-4-yl-7-[1-[4-(trifluoromethoxy)phenyl]sulfonyl-4-piperidyl]-3H-imidazo[4,5-b]pyridine; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[rac-(2R,3S)-3-aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[3-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-methylmorpholin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(7-Oxa-4-azaspiro[2.5]octan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[6,6-dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[6,6-dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[1-(Oxetan-3-yl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-Oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-(2-Morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1-(oxetan-3-yl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-3-fluoro-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[rac-(2R,3S)-3-aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -(cis)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)cyclohexyl]-[4-(trifluoromethoxy)-1-piperidyl]methanone; -(trans)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)cyclohexyl]-[4-(trifluoromethoxy)-1-piperidyl]methanone; -[4-[2-(4-amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -(trans)-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(7-oxa-4-azaspiro[2.5]octan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-Cyclopent-3-en-1-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(2-Amino-4-bromo-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(4-Amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -N-[2-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-5-(trifluoromethoxy)phenyl]acetamide; -(trans)-[4-[2-(3-Methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1,2,3,6-Tetrahydropyridin-5-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[4-Phenylpyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[4-Fluoropyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-Amino-3,3,3-trifluoro-propyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[6-(Aminomethyl)-3-pyridyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[rac-(3R,4S)-4-(4-Pyridyl)pyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Amino-2-bicyclo[2.2.1]hept-5-enyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[Pyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Amino-2-thienyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -4-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidine-4-carbonitrile; -[4-[2-[2-Piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4-Aminotetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Amino-4-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[Pyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1,2,3,4-Tetrahydroisoquinolin-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Amino-5-hydroxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1H-Indol-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4,5,6,7-Tetrahydrothieno[3,2-c]pyridin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(Azetidin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; 2,2,2-Trifluoroacetic acid -[4-[2-(3-Oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4-Amino-3-pyridyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[Piperazin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Aminocyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[3-(Methylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-Azabicyclo[4.1.0]heptan-7-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[4-Hydroxy-6-(trifluoromethyl)-3-quinolyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Oxabicyclo[3.1.0]hexan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -N-[4-Hydroxy-2-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]phenyl]acetamide; -5,6-Dimethyl-3-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1H-pyridin-2-one; -1-[3,5-Dimethyl-4-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1H-pyrrol-2-yl]ethanone; -[4-[2-[1-(1,1-Dioxothiolan-3-yl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1-Methylsulfonylazetidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Hydroxy-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(1,4-Oxazepan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[4-Hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-(1,1,2,2-Tetrafluoroethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(1,1,2,2,2-Pentafluoroethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Phenyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(2,2,3,3-Tetrafluoro-1,4-benzodioxin-6-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[4-Hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[7-oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[rac-(1S,3S)-3-Aminocyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-(2-Cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4-Methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[7-oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-cyclopent-3-en-1-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(Azepan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[4-Amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Hydroxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[rac-(1R,3S)-3-Aminocyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[4-[2-(3-Fluoro-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1,2,3,6-Tetrahydropyridin-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -3-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]bicyclo[1.1.1]pentane-1-carboxylic acid; -3-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-6-(trifluoromethyl)-1H-pyridin-2-one; -[4-(Difluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1,1-dioxothiolan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[1,4-oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1,4-oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -(trans)-4-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]cyclohexanecarboxylic acid; -(cis)-[4-[2-[3-Aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1,1-Dioxothiolan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4-Hydroxy-4-methyl-cyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[4-Hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(4-Hydroxy-4-methyl-cyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[4-Hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1,2,3,6-Tetrahydropyridin-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[Azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[Azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-Cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-Tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[4-[2-(4-Methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[4-[2-(4-Methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(4-Methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(4-Methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[Tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[Tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(3-Methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-(pentafluoro-λ 6-[4-[2-(4-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; hydrochloride; 6 -[4-[2-[Morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6 -[4-(2-N-Morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[2-(4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6 -[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6 -(cis)-[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6 -(trans)-[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6-Sulfanyl)phenyl]-[4-(2-N-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(trans)-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[4-[2-(1-cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[4-[2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -(cis)-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6-sulfanyl)phenyl]-[4-[2-(1-cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-(methylamino)-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[2-[4-methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(cis)-[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6-sulfanyl)phenyl]-[4-[2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[2-[4-methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(cis)-[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[4-[2-[2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -3-methyl-3-[7-[1-[4-(pentafluoro-λ 6 -sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]cyclobutanone; -[4-[2-(1-Hydroxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(1-hydroxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[(cis)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[(trans)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-fluoro-4-(6-fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(3-Hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(3-hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[2-Hydroxy-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[(cis)-2-methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[(trans)-2-methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(6-Fluoro-2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-Fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(cis)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Fluoro-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(trans)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(cis)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-(6-Fluoro-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[6-Methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6-[4-(6-Fluoro-2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[4-(6-Fluoro-2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[4-(6-Fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; 6 -[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[2-[4-(hydroxymethyl)-1-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6 -[4-[6-Fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[4-(6-Fluoro-2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -(trans)-[4-[6-Fluoro-2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6-sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-fluoro-2-[2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[2-[3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-(6-fluoro-2-thiomorpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-fluoro-2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-[6-methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ6 -[4-[6-Fluoro-2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -5-[6-Fluoro-7-[1-[4-(pentafluoro-λ -sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one; 6 -(trans)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-(2-cyclopentyl-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; 6 -[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[2-[3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6 -[4-[6-Fluoro-2-[oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[6-Fluoro-2-[oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6-[4-[6-Fluoro-2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[4-[6-Fluoro-2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[4-[6-Fluoro-2-(3-hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6 -(trans)-[2-Amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6 -[4-(2-Cyclopentyl-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; 6 -[4-[6-Fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-5-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(1-Cyclopropyl-4-piperidyl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(6-Fluoro-2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1-Methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[6-Fluoro-2-[tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(trans)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[6-Fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(trans)-(4-(6-Fluoro-2-(4-hydroxy-4-methylcyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperidin-1-yl)(4-(pentafluoro-λ6-sulfanyl)phenyl)methanone; -(cis)-[4-[6-Fluoro-2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[4-[6-Fluoro-2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -4-(6-Fluoro-2-N-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[4-[6-Fluoro-2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(3,4,4a,5,7,7a-hexahydro-2H-furo[3,4-b][1,4]oxazin-2-yl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ 6-Sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -2-[6-fluoro-7-[1-[4-(pentafluoro-λ6-sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-2,3,4a,5,7,7a-hexahydrofuro[3,4-b][1,4]oxazine-4-carboxylic acid; -[4-[2-(1,1-dioxo-1,4-thiazinan-2-yl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(2-amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; and -7-[6-Fluoro-7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-2-oxa-5-azaspiro[3.5]nonane-5-carboxylic acid, A compound selected from the group consisting of and pharmaceutically acceptable salts thereof is provided.

[0029] A further aspect provides a compound as defined above having an IC 50 value of less than about 2 μM, such as less than about 1 μM, 0.5 μM, 0.2 μM, 100 nM or 50 nM, against ERK5.

[0030] A further aspect provides a pharmaceutical composition comprising a compound as defined above and at least one pharmaceutically acceptable excipient or carrier.

[0031] A further aspect provides a compound or pharmaceutical composition as defined above for use in therapy.

[0032] A further aspect provides a compound or pharmaceutical composition as defined above for use in the treatment or prevention of cancer.

[0033] In an embodiment, the cancer is characterized by an increase in MAPK7 expression and / or an increase in ERK5 activity.

[0034] In an embodiment, the cancer is selected from leukemia, breast cancer, multiple myeloma, colon cancer, renal cell carcinoma, mesothelioma, adenocarcinoma, neuroblastoma, and hepatocellular carcinoma.

Mode for Carrying Out the Invention

[0035] Here, specific embodiments of the present disclosure will be described with reference to the description and examples. However, such embodiments are only examples and represent a small number of the many possible specific embodiments that can represent the application of the principles of the present disclosure. It should be understood that various changes and modifications will be apparent to those skilled in the art in view of the benefits of the present disclosure and are considered to be within the spirit and scope of the present disclosure as further defined in the appended claims.

[0036] Definition Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present disclosure, exemplary methods, devices, and materials are described herein. All technical and patent publications mentioned herein are hereby incorporated by reference in their entirety.

[0037] The practice of the present disclosure, unless otherwise specified, uses conventional techniques of chemical synthesis, tissue culture, immunology, molecular biology, microbiology, cell biology, recombinant DNA, etc., within the skill of the art. For example, see: Michael R. Green and Joseph Sambrook, Molecular Cloning (4 th ed., Cold Spring Harbor Laboratory Press 2012); the series Ausubel et al. eds. (2007) Current Protocols in Molecular Biology; the series Methods in Enzymology (Academic Press, Inc., N.Y.); MacPherson et al. (1991) PCR 1: A Practical Approach (IRL Press at Oxford University Press); MacPherson et al. (1995) PCR 2: A Practical Approach; Harlow and Lane eds. (1999) Antibodies, A Laboratory Manual; Freshney (2005) Culture of Animal Cells: A Manual of Basic Technique, 5 thedition; Gait ed. (1984) Oligonucleotide Synthesis; U.S. Patent No. 4,683,195; Hames and Higgins eds. (1984) Nucleic Acid Hybridization; Anderson (1999) Nucleic Acid Hybridization; Hames and Higgins eds. (1984) Transcription and Translation; Immobilized Cells and Enzymes (IRL Press (1986)); Perbal (1984) A Practical Guide to Molecular Cloning; Miller and Calos eds. (1987) Gene Transfer Vectors for Mammalian Cells (Cold Spring Harbor Laboratory); Makrides ed. (2003) Gene Transfer and Expression in Mammalian Cells; Mayer and Walker eds. (1987) Immunochemical Methods in Cell and Molecular Biology (Academic Press, London); Herzenberg et al. eds (1996) Weir’s Handbook of Experimental Immunology; Manipulating the Mouse Embryo: A Laboratory Manual, 3 rd edition (Cold Spring Harbor Laboratory Press (2002)); Sohail (ed.) (2004) Gene Silencing by RNA Interference: Technology and Application (CRC Press).

[0038] All numerical designations (e.g., pH, temperature, time, concentration, molecular weight, etc., including ranges) are approximate values that vary, where appropriate, in increments of, for example, 0.1 or 1.0, in either the (+) or (-) direction. Although not necessarily explicitly stated, it should be understood that there is a term "about" used before all numerical designations to indicate the conventional level of variability. For example, a numerical designation that is "about" a given value can vary by ±10% of that value, or this variation can be ±5%, ±2%, or ±1% of this value. Also, although not necessarily explicitly stated, it should be understood that the reagents described herein are merely exemplary and that equivalents thereof are known in the art.

[0039] As used in this specification and the claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. For example, the term "cell" includes a plurality of cells (including mixtures thereof). Unless otherwise specified or clear from the context, as used in this specification, the term "or" is understood to be inclusive. The term "comprising" is used herein to mean "including but not limited to" and is used interchangeably with this phrase.

[0040] As used herein, the terms "comprising" or "comprises" are intended to mean that the compositions and methods include the recited elements without excluding other elements. "Consisting essentially of" is meant to exclude any other elements that are essential for the stated purpose when used to define compositions and methods. Thus, a composition consisting essentially of the elements defined herein will not exclude trace impurities from isolation and purification methods, and pharmaceutically acceptable carriers such as phosphate buffered saline, preservatives, etc. "Consisting of" is meant to exclude other components in amounts greater than trace elements, as well as substantial method steps for administering the disclosed compositions, or process steps for manufacturing the composition or achieving the intended result. Embodiments defined by each of these transitional terms are within the scope of the present disclosure. The use of the term "comprising" herein is intended to encompass and disclose corresponding descriptions where the term "comprising" is replaced by "consisting essentially of" or "consisting of".

[0041] "Subject", "individual", or "patient" are used interchangeably herein and refer to vertebrates such as mammals. Mammals include, but are not limited to, rodents, livestock, sports animals, pets, and primates such as mice, rats, rabbits, monkeys, cows, sheep, pigs, dogs, cats, horses, and humans. In certain embodiments, the mammal is a human.

[0042] "Administering", as used herein, is defined as a means of providing a drug or a composition containing the drug to a subject in a manner that brings the drug into contact with the subject's body (e.g., internally). Such administration can be by any route including, but not limited to, oral, transdermal (e.g., by vaginal, rectal, or oral mucosa), injection (e.g., subcutaneous, intravenous, parenteral, intraperitoneal, or intracerebral), or inhalation (e.g., oral or nasal). Administration can also include providing a substance or composition to a part of the surface of the subject's body, e.g., by topical administration to the skin. Pharmaceutical formulations are, of course, administered in a form suitable for each route of administration.

[0043] "Treating" or "treatment" of a disease includes the following: (1) preventing a disease, i.e., not causing the clinical symptoms of the disease in a patient who may be susceptible to the disease but has not yet experienced or manifested the symptoms of the disease; (2) inhibiting a disease, i.e., stopping or reducing the onset of the disease or its clinical symptoms; and / or (3) alleviating a disease, i.e., causing regression of the disease or its clinical symptoms.

[0044] The term "suffering from", when used in relation to the term "treatment", refers to a patient or individual who has been diagnosed with a disease or is susceptible to the disease. A patient may also be said to "be at risk of suffering from" a disease due to a family history of the disease in the patient's family or the presence of a genetic mutation associated with the disease. A patient at risk of a disease has not yet developed all or part of the characteristic pathology of the disease.

[0045] "Effective amount" or "therapeutically effective amount" means an amount sufficient to produce a beneficial or desired result. An effective amount can be administered in one or more administrations, applications, or dosages. Such delivery depends on many variables including the period during which individual dosage units are used, the bioavailability of the therapeutic agent, the route of administration, and the like. However, the specific dosage level of the therapeutic agent of the present disclosure for any particular subject depends on a variety of factors, such as the activity of the specific compound utilized, the age, weight, general health, sex, and diet of the subject, the time of administration, the rate of excretion, drug combination, the severity of the particular disorder being treated, and the form of administration. Therapeutic dosages can generally be titrated to optimize safety and effectiveness. Typically, the dose-effect relationship from in vitro and / or in vivo testing can initially provide useful guidance regarding a suitable dosage for patient administration. Generally, it will be desirable to administer an amount of the compound effective to achieve a serum level commensurate with the concentration found to be effective in vitro. Determination of these parameters is well within the skill of the ordinarily skilled artisan. These considerations, as well as effective formulations and administration procedures, are well known in the art and are described in standard texts. Consistent with this definition, as used herein, the term "therapeutically effective amount" means an amount sufficient to treat (e.g., ameliorate) one or more symptoms associated with a condition. The total daily dosage may be administered in a single or divided dose and may, at the discretion of the physician, deviate from the typical ranges set forth herein.

[0046] As used herein, the terms "increase" and "elevation" are used interchangeably and include any measurable increase in biological function and / or biological activity and / or concentration. For example, the increase can be at least about 10%, such as at least about 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, or 95%, such as at least about 95%, 96%, 97%, 98%, 99%, or 100%. Thus, the increase can be at least about 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold or 10-fold, such as at least about 20-fold, 25-fold, 50-fold, 100-fold or more, compared to the amount or function, or activity or concentration of a control or baseline.

[0047] As used herein, the terms "increased expression" and / or "increased activity" of a substance such as ERK5 in a sample or in cancer or a patient typically refer to an increase in the amount of the substance (e.g., the MAPK7 gene product or the ERK5 protein), but can also mean an increase in the biological activity of the substance (e.g., constitutive activation of phosphorylation and / or a decrease in the discrimination of the phosphorylation site of ERK5). For example, the increase can be an amount of about 5%, such as about 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95%, such as about 96%, 97%, 98%, 99% or 100%. Thus, the increase can be about 2-fold, 3-fold, 4-fold, 5-fold, 6-fold, 7-fold, 8-fold, 9-fold or 10-fold, such as about 20-fold, 25-fold, 50-fold, 100-fold or more, relative to the amount (or activity) of a substance such as ERK5 in a control sample or a plurality of control samples, e.g., an individual or population of individuals not suffering from a disease or disorder (e.g., cancer) or an internal control, as determined by techniques known in the art. If the expression and / or activity of ERK5 is increased by 1 standard deviation, 2 standard deviations, 3 standard deviations, 4 standard deviations, 5 standard deviations or more compared to the mean (average value) or median amount of ERK5 in a control group of samples or a baseline group of samples or a retrospective analysis of patient samples, the subject can also be determined to have "increased expression" or "increased activity" of ERK5. As practiced in the art, such control or baseline expression levels can be determined or measured prior to measurement in a sample or in cancer or a subject, or can be obtained from a database of such control samples.

[0048] As used herein, the term "pharmaceutically acceptable excipient" encompasses any of the standard pharmaceutical excipients as described, for example, in Remington’s Pharmaceutical Sciences (20th ed., Mack Publishing Co. 2000). Such excipients include carriers such as phosphate buffered saline, water, and emulsions such as oil / water or water / oil emulsions, as well as various types of wetting agents. The pharmaceutical composition can also include stabilizers, preservatives, adjuvants, fillers, binders, lubricants, and the like.

[0049] As used herein, the term "alkyl" means a saturated straight-chain or branched free radical consisting essentially of carbon atoms and the corresponding number of hydrogen atoms. Exemplary alkyl groups include methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, and the like. Other alkyl groups will be readily apparent to those skilled in the art in view of the benefits of the present disclosure. Terms such as "(C1-C3)alkyl", "(C1-C6)alkyl", etc. have an equivalent meaning, i.e., a saturated straight-chain or branched free radical consisting essentially of 1 to 3 (or 1 to 6) carbon atoms and the corresponding number of hydrogen atoms. The definition of "alkyl" also applies in the context of other groups containing an alkyl group, such as "O(C1-C3)alkyl". The term "haloalkyl" means an alkyl group substituted by one or more halogens. Exemplary haloalkyl groups include trifluoromethyl, trifluoroethyl, difluoroethyl, pentafluoroethyl, chloromethyl, and the like. One or more carbon atoms in the backbone of the alkyl group can be substituted (or bonded) by a heteroatom by a multiple bond (e.g., a double bond), for example, a carbon atom of the alkyl group can be bonded to oxygen via a double bond (i.e., can be substituted by oxo to provide a carbonyl function). The presence of such a substituent does not prevent the carbon backbone of the free radical from being considered an alkyl group.

[0050] As used herein, the term "cyclic group" means a saturated, partially or fully unsaturated, or aromatic group having at least 3 to 10 atoms (i.e., ring atoms) that form a ring. When a cyclic group is defined as having a specific number of members, terms such as "member", "membered", etc. are used to indicate the number of ring atoms in the cyclic group. For example, a 5-membered cyclic group (e.g., a 5-membered heterocyclic group) contains 5 ring atoms. It will be understood that a cyclic group can be part of a larger cyclic system. For example, bicyclo[4.3.0]nonane contains two carbocyclic groups, i.e., a cyclohexane group and a cyclopentane group, fused to form the carbocyclic system of the molecule. The term "cyclic group" is intended to encompass both carbocyclic groups and heterocyclic groups. The term "carbocyclic" refers to a group having at least 3 to 9 carbon atoms that form a ring. The term "heterocyclic" refers to a group having at least 3 to 10 atoms that form a ring, at least 1 to 9 of the ring atoms being carbon and the remaining at least 1 to 9 ring atoms (i.e., hetero ring atoms) being independently selected from the group consisting of nitrogen, sulfur, and oxygen.

[0051] As used herein, the term "spiro" or "spirocyclic" with respect to a cyclic group means that a first cyclic group within a polycyclic system is bonded to a second cyclic group within the polycyclic system, and the ring atoms of the first cyclic group and the ring atoms of the second cyclic group have only one common atom, i.e., the first cyclic group and the second cyclic group share only one common ring atom. For example, the spiro[5.5]undecanyl group contains two cyclohexane rings that commonly have a single carbocyclic atom.

[0052] As used herein, the term "fused" with respect to a cyclic group means that a first cyclic group within a polycyclic system is bonded to a second cyclic group within the polycyclic system, and the ring atoms of the first cyclic group and the ring atoms of the second cyclic group commonly have two adjacent atoms, i.e., the first cyclic group and the second cyclic group share two common ring atoms. For example, the bicyclo[4.4.0]decanyl group contains two cyclohexane rings that commonly have two adjacent carbocyclic atoms.

[0053] As used herein with respect to cyclic groups, the term "bridged" means that a first cyclic group within a polycyclic system is bonded to a second cyclic group within the polycyclic system, and the ring atoms of the first cyclic group and the ring atoms of the second cyclic group commonly have more than two adjacent atoms, i.e., the first cyclic group and the second cyclic group share three or more common ring atoms. For example, the bicyclo[3.3.1]nonanyl group contains two cyclohexane rings that commonly have three adjacent carbon ring atoms.

[0054] In the structural formulas described herein, any ring system (including any spiro, fused, or bridged ring system) can be connected to other parts of the molecule via any atom having an appropriate valence. For example, a bicyclic ring can be connected to another part of the molecule via a ring atom (e.g., a heteroatom such as a second carbon atom or N), or a bridgehead (e.g., a third carbon atom). Spiro, fused, and bridged rings can be completely unsaturated, partially unsaturated, or completely saturated, and one or more of the rings constituting them can have aromatic characteristics.

[0055] As used herein, the term "cycloalkyl" means a saturated free radical having at least 3 to 9 carbon atoms (i.e., ring atoms) forming a ring. Exemplary cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. It should be understood that the cycloalkyl group can be monocyclic or polycyclic (e.g., fused, bridged, or spirocyclic). In the case of a polycyclic cycloalkyl group, there is further a ring, e.g., one or more additional rings, all of which contain 3 to 7 carbon atoms (i.e., ring atoms). An exemplary cycloalkyl group having such an additional ring is bicyclo[1.1.1]pentanyl. The term "(C3-C7)cycloalkyl" indicates that the cycloalkyl group contains 3 to 7 carbon atoms in the ring portion of the group, which can be monocyclic or polycyclic (e.g., fused, bridged, or spirocyclic), e.g., cyclopropanyl (having 3 ring carbon atoms) or bicyclo[1.1.1]pentanyl (having 5 ring carbon atoms). One or more ring atoms of the cycloalkyl group can be substituted (i.e., bonded) by a heteroatom by a double bond (e.g., cycloalkyl substituted with oxo). The presence of such a substituent does not prevent the carbon skeleton of the free radical from being considered a cycloalkyl group.

[0056] As used herein, the term "cycloalkenyl" means an unsaturated (i.e., partially or fully unsaturated) free radical having at least 3 to 9 carbon atoms (i.e., ring atoms) that form a ring. The term "cycloalkenyl" is not intended to include cyclic groups having aromatic character (those considered aryl groups as defined herein). Exemplary cycloalkenyl groups include cyclohexenyl. It will be understood that the cycloalkenyl group can be monocyclic or polycyclic (e.g., bridged). In the case of a polycyclic cycloalkenyl group, there is one or more additional rings, all of which contain 3 to 9 carbon atoms (i.e., ring atoms). These additional rings can be saturated or unsaturated. Exemplary cycloalkenyl groups having such additional rings include bicyclo[2.2.1]hept-5-enyl. The term "(C4-C8)cycloalkenyl" indicates that the cycloalkenyl group contains 4 to 8 carbon atoms in the ring portion of the group, e.g., cyclohexynyl (having 6 ring carbon atoms) or bicyclo[2.2.1]hept-5-enyl (having 7 ring carbon atoms). Double bonds (or linkages) within the cycloalkenyl group are typically between ring carbon atoms (i.e., within the ring), but can also be between one ring carbon atom and an adjacent non-ring carbon atom (i.e., outside the ring).

[0057] As used herein, the term "aryl" means an aromatic free radical having at least 6 carbon atoms (i.e., ring atoms) forming the ring. It will be understood that the aryl group can be monocyclic or polycyclic (e.g., fused). In the case of a polycyclic aryl group, there is one or more additional rings, all of which contain at least 3 carbon atoms (i.e., ring atoms). The additional rings can also contain one or more heteroatoms, which can be saturated, unsaturated, or aromatic. The polycyclic aryl group is typically attached to the remainder of the molecule via an aromatic ring and typically not via a ring containing a heteroatom. In embodiments, the polycyclic aryl group does not contain ring heteroatoms. Examples of aryl groups include the phenyl group and the naphthalenyl group, as well as the indenyl group and the indanyl group. Other aryl groups include, for example, tetrahydroisoquinolinyl attached to the remainder of the molecule via its phenyl ring. The term " (C6~C 10 )aryl" indicates that the aryl group contains 6 to 10 carbon atoms in the ring portion of the group, which can be monocyclic or polycyclic (e.g., fused), and can be, for example, phenyl (having 6 ring carbon atoms) or indanyl (having 9 ring carbon atoms).

[0058] As used herein, the term "heterocycloalkyl" means a saturated free radical having at least 3 to 10 atoms (i.e., ring atoms) forming a ring, at least 1 to 9 of said ring atoms being carbon, and the remaining at least 1 to 9 ring atoms (i.e., hetero ring atoms) being independently selected from the group consisting of nitrogen, sulfur, and oxygen. For example, the term "4- to 10-membered heterocycloalkyl" means a saturated free radical containing 4 to 10 ring atoms, one or more of which are hetero ring atoms. A heterocycloalkyl ring may typically have an oxo substituent adjacent to a hetero atom (e.g., 2-oxopyrrolidinyl), but the oxygen atom does not form part of the ring and is excluded from the count of ring atoms. The presence of such a substituent does not prevent the ring (or rings) of the free radical from being considered a heterocycloalkyl group. Exemplary heterocycloalkyl groups include tetrahydrofuranyl, piperidinyl, morpholinyl, and piperazinyl. Any ring sulfur atom may optionally carry one or more pendant (i.e., non-ring) oxygen atoms, as seen in the sulfolanyl group. In the case of a polycyclic heterocyclic group, additional rings, e.g., one or more rings, are present, all of which contain 3 to 7 ring atoms selected from carbon, nitrogen, sulfur, and oxygen. The additional rings may be saturated or partially or fully unsaturated (e.g., having aromatic character). Polycyclic heterocyclic groups include fused, bridged, and spirocyclic ring systems. When a polycyclic heterocycloalkyl group contains an unsaturated fused ring, the group typically does not bond to the remainder of the molecule through its fused ring. Exemplary heterocyclic groups having such additional rings include 2-oxaspiro[3.3]heptanyl, tetrahydroisoquinolinyl, 1-azaspiro[3.3]heptan-2-one, and 2-azabicyclo[4.1.0]heptanyl. When a heterocycloalkyl group is described as "X-Y membered" (X and Y are integers), this means that the heterocycloalkyl group contains a total of X to Y ring atoms. Thus, for example, a "4- to 7-membered heterocycloalkyl group" contains a total of 4, 5, 6, or 7 ring atoms and is, for example, tetrahydropyranyl (6 ring atoms).

[0059] As used herein, the term "heterocycloalkenyl" means an unsaturated (i.e., partially or fully unsaturated) free radical having at least 3 to 6 atoms (i.e., ring atoms) forming a ring, at least 1 to 5 of said ring atoms being carbon and the remaining at least 1 to 5 ring atoms (i.e., hetero ring atoms) being independently selected from the group consisting of nitrogen, sulfur and oxygen. The heterocycloalkenyl ring may typically have an oxo substituent adjacent to a hetero atom, provided that the oxygen atom does not form part of the ring and is excluded from the count of ring atoms. An exemplary heterocycloalkenyl group is tetrahydropyridyl. Any ring sulfur atom may optionally carry one or more pendant (i.e., acyclic) oxygen atoms. It is to be understood that the heterocycloalkenyl group may be monocyclic or polycyclic (e.g., bridged). In the case of a polycyclic heterocycloalkenyl group, additional rings, e.g., one or more additional rings, are present, all of which contain 3 to 6 ring atoms selected from carbon, nitrogen, sulfur and oxygen. The additional rings may be saturated or partially or fully unsaturated (e.g., having aromatic character). Polycyclic heterocycloalkenyl groups include fused, bridged and spirocyclic ring systems. When a polycyclic heterocycloalkenyl group contains an unsaturated fused ring, the group is typically not attached to the remainder of the molecule through its fused ring. An exemplary heterocycloalkenyl group having such additional rings is tetrahydroindolyl. When a heterocycloalkenyl group is described as being "X- to Y-membered", this means that the heterocycloalkenyl group contains a total of X to Y ring atoms. Thus, for example, a "5- to 8-membered heterocycloalkenyl group" contains a total of 5, 6, 7 or 8 ring atoms and is, for example, dihydropyranyl (6 ring atoms).

[0060] As used herein, the term "heteroaryl" typically means an aromatic (i.e., having aromatic character) free radical containing from 6 to 10 ring atoms, wherein from 1 to 9 of said ring atoms are carbon and the remaining 1 to 9 ring atoms (i.e., hetero ring atoms) are independently selected from the group consisting of nitrogen, sulfur, and oxygen. It is to be understood that heteroaryl groups can be monocyclic or polycyclic (e.g., fused). In the case of polycyclic heteroaryl groups, there is one or more additional rings, e.g., one or more additional rings, all of which contain at least 3 atoms (i.e., ring atoms), and the additional rings can optionally be aromatic. Examples of heteroaryl groups include monocyclic groups such as pyridyl, and polycyclic groups such as 2-oxopyridinyl and indolyl. When a heteroaryl group is described as "X- to Y-membered", this means that the heteroaryl group contains a total of X to Y ring atoms. Thus, for example, a "5- to 10-membered heteroaryl group" contains a total of 5, 6, 7, 8, 9, or 10 ring atoms, such as indolyl (9 ring atoms).

[0061] As used herein, the terms "halo" and "halogen" mean fluorine, chlorine, bromine, or iodine. These terms are used interchangeably and can refer to a halogen free radical group or such a halogen atom. One of ordinary skill in the art will be able to readily identify which is meant in the context in which this term is used in the present disclosure.

[0062] As used herein, the term "CN" means a free radical having a carbon atom linked to a nitrogen atom via a triple bond. The CN radical is bonded through its carbon atom.

[0063] As used herein, the term "oxo" means a free radical in which an oxygen atom is connected to the atom having this radical via a double bond. For example, when a carbon atom bears an oxo radical, a carbon-oxygen double bond is formed. It is to be understood that not all atoms within a given structure can be substituted with oxo, which depends on the valence of the atom being substituted.

[0064] As used herein, “-C(O)-” means [Chem.] and “-S(O)2-” means As used herein, “-S(O)2-” means [Chem.] and “-C(O)NH-” means As used herein, “-C(O)NH-” means [Chem.] and “-NHC(O)-” means As used herein, “-NHC(O)-” means [Chem.] .

[0065] The compounds of the present disclosure are particularly described by structural formulas. These formulas typically show only one form of the compound (e.g., resonance form, tautomeric form, etc.), but it will be understood that a particular compound may exist in multiple such forms. This will be readily apparent to the skilled reader. The present disclosure includes all possible tautomers of the compounds characterized by the structural formulas before and after, as a single tautomer or as any mixture of tautomers in any ratio. It should also be understood that certain ones of the present compounds may exist in one or more isomeric (e.g., stereoisomeric) forms. The present disclosure includes all possible stereoisomers, enantiomers, diastereomers, etc. of the compounds described before and after, as well as their cis- and trans-forms and conformations. The purification and separation of isomers can be achieved by the methods described below and by techniques known in the art. For example, the optical isomers of a compound can be obtained by the resolution of a racemic mixture of its diastereomeric salts (e.g., using an optically active acid or base or by the formation of covalent diastereomers). Different processes for the separation of optical isomers include the use of chiral chromatography (e.g., an HPLC column using a chiral phase), with or without conventional derivatization. Enzymatic separation may also be useful, with or without derivatization, and the optically active compounds of the present disclosure can be obtained similarly by chiral synthesis using optically active starting materials. The present disclosure includes all possible stereoisomers of the compounds described herein as a single stereoisomer or as any mixture of said stereoisomers, e.g., as the (R)- or (S)-isomers, in any ratio.

[0066] The compounds of the present disclosure may exist in the form of a free acid or base or as an addition salt with a suitable acid or base. For example, a basic compound of formula (I) may be provided as a pharmaceutically acceptable acid addition salt having an acid such as HCl, TFA, or formic acid (e.g., HCl). Methods for forming salts are described below and are also known in the art (see, e.g., Berge et al., J Pharm Sci. (1977) 66:1-19).

[0067] As used herein, the term "pharmaceutically acceptable" when used in relation to a salt means a salt of a compound of the present disclosure that can be administered without resulting in any substantial adverse biological effects or resulting harmful interactions with any of the other components of the pharmaceutical composition that may be included.

[0068] Any reference to a list of chemical groups in any definition of a variable herein includes that definition of the variable as any single group or combination of the listed groups. The recitation of embodiments regarding a variable or aspect herein includes this embodiment either as any single embodiment or in combination with any other embodiment or portion thereof.

[0069] The compositions and methods provided herein can be combined with any one or more of the other compositions and methods provided herein.

[0070] The following abbreviations and experiment-based formulas are used herein. Ac acetyl ADDP 1,1'-(azodicarbonyl)dipiperidine ATP adenosine triphosphate BOC / Boc tert-butyloxycarbonyl Bn benzyl BuLi butyllithium CDI 1,1'-carbonyldiimidazole DAD diode array detection DBU 1,8-diazabicyclo[5.4.0]undec-7-ene DCM dichloromethane DIEA / DIPEA diisopropylethylamine Diox 1,4-dioxane 4-DMAP 4-dimethylaminopyridine DMF N,N-dimethylformamide DMSO dimethyl sulfoxide 4EBP1 eukaryotic translation initiation factor 4E-binding protein 1 EDC / EDCI 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide ee enantiomeric excess ERK extracellular signal-regulated kinase EtOAc / AcOEt Ethyl acetate ES electrospray ionization FRET Forster resonance energy transfer HATU Hexafluorophosphate azabenzotriazole tetramethyluronium IPA Isopropyl alcohol Ir[dF(CF3)ppy]2(dtbpy))PF6 [4,4’-Bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1’]bis[3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate LC / MS Liquid chromatography / mass spectrometry LED Light emitting diode MAPK / MEK Mitogen-activated protein kinase Me Methyl MeCN / ACN Acetonitrile MeOH Methanol MeTHF 2-Methyltetrahydrofuran MS Mass spectrometry MTBE Methyl tert-butyl ether Pd / C Palladium on carbon PDA Photodiode array Pd2(dba)3 Tris(dibenzylideneacetone)dipalladium(0) Pd(dppf)Cl2 [1,1’-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) Pd(PPh3)2Cl2 Bis(triphenylphosphine)palladium(II) dichloride PhOK Potassium phenolate PMB p-Methoxybenzyl PPh3 Triphenylphosphine Py Pyridine rac Racemic mixture RPMI Roswell Park Memorial Institute medium RT Room temperature SCX Strong cation exchange SFC Supercritical fluid chromatography TAD Transcription activation domain TATU O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate TBAF Tetrabutylammonium fluoride TBTU 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate TEA Triethylamine TFA Trifluoroacetic acid THF Tetrahydrofuran TLC Thin layer chromatography t RA Retention time uma Unified atomic mass unit UV Ultraviolet

[0071] Compound In a first aspect, the present disclosure provides a compound of formula (I)

Chemical formula

[0072] In an embodiment, the compound is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from -H, -(C1-C6) alkyl, -(C3-C7) cycloalkyl, -(C4-C8) cycloalkenyl, -(C6-C 10 ) aryl, 4-10 membered heterocycloalkyl, 5-8 membered heterocycloalkenyl, and 5-10 membered heteroaryl, and R 1 is optionally substituted in one or more occurrences of R A , each R Ais independently selected from halo, -OH, -NHR’, -CN, oxo, -SO2CH3, -(C1-C3)alkyl, -O(C1-C3)alkyl, -C(O)R’’, -C(O)NHR’, -NHC(O)R’’, -(C3-C6)cycloalkyl, 3- to 6-membered heterocycloalkyl, phenyl, and pyridyl, and each occurrence of -(C1-C3)alkyl, -O(C1-C3)alkyl, and phenyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH2, and -CN, and / or R A wherein two occurrences of R are taken together with the atoms to which they are attached to form a (C3-C6)cycloalkyl group or a 3- to 6-membered heterocycloalkyl group, each R’ is independently selected from -H, methyl, and phenyl, each R’’ is independently selected from methyl, phenyl optionally substituted with -OCF3, and tetrahydrofuranyl, L 1 is selected from a direct bond, -O-, -CH2-, and -CH=, R 2 is selected from -(C3-C6)cycloalkyl, 5- to 10-membered heterocycloalkyl, -(C6-C 10 )aryl, and 5- to 10-membered heteroaryl, and R 2 is optionally substituted at one or more occurrences of R B , each R B is selected from halo, -OH, -NH2, -NO2, -CN, -SF5, -B(OH)2, -(C1-C3)alkyl, -O(C1-C3)alkyl, -(C3-C6)cycloalkyl, -SO2CH3, phenyl, benzyl, 1-λ 6 -2-thiazolidine-1,1-dionyl and pyridyl, and each occurrence of -(C1-C3)alkyl, -O(C1-C3)alkyl, -(C3-C6)cycloalkyl, phenyl, and benzyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH2, and -CF3, Furthermore, when R 2 is -(C3-C6)cycloalkyl, R 2is optionally substituted at one ring atom by a spirocyclic oxindolyl group, L 2 is selected from a direct bond, -CH2-, -CH2CH2-, and -CH2O-, where L 2 (when present) is optionally substituted with -NH2 or methyl, R 3 is selected from -H, halo, -OH, and methyl optionally substituted with -OH, R 4 is -H or -NH2, R 5 is -H or methyl, X and Y are each independently selected from CH and N (provided that when Y is N, X is also N), E is selected from -C(O)-, -S(O)2-, and -O- (provided that when E is -O-, both X and Y are CH), n is 0, 1, or 2.

[0073] In an embodiment, the compound is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from -H, -(C1-C6)alkyl, -(C3-C7)cycloalkyl, -(C4-C8)cycloalkenyl, -(C6-C 10 )aryl, 4-10 membered heterocycloalkyl, 5-8 membered heterocycloalkenyl, and 5-10 membered heteroaryl, and R 1 is optionally substituted at one or more occurrences of R A , each R A is independently selected from halo, -OH, -NHR’, -CN, oxo, -SO2CH3, -(C1-C3)alkyl, -O(C1-C3)alkyl, -C(O)R’’, -NHC(O)R’’, -(C3-C6)cycloalkyl, 3-6 membered heterocycloalkyl, phenyl, and pyridyl, and each occurrence of -(C1-C3)alkyl, -O(C1-C3)alkyl, and phenyl is optionally substituted with one or more groups independently selected from halo, -OH, and -NH2, and / or R A Two occurrences of A may combine with the atom to which they are attached to form a (C3-C6) cycloalkyl group or a 3- to 6-membered heterocycloalkyl group, each R' is independently selected from -H and methyl, each R'' is independently selected from -OH, methyl, and tetrahydrofuranyl, L 1 is selected from a direct bond and -CH2-, R 2 is selected from -(C3-C6) cycloalkyl, 5- to 10-membered heterocycloalkyl, -(C6-C 10 ) aryl, and 5- to 10-membered heteroaryl, and R 2 is optionally substituted in one or more occurrences of R B , each R B is selected from halo, -OH, oxo, -NH2, -NHMe, -NO2, -CN, -SF5, -SiMe3, -(C1-C3) alkyl, -O(C1-C3) alkyl, -(C3-C6) cycloalkyl, -O(C3-C6) cycloalkyl, -SO2CH3, -NHC(O)Me, -NHC(O)OC(CH3)3, phenyl, benzyl, and 1-λ 6 -2-thiazolidine-1,1-dionyl, and each occurrence of -(C1-C3) alkyl, -O(C1-C3) alkyl, -(C3-C6) cycloalkyl, phenyl, and benzyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH2, and -CF3, Further, when R 2 is -(C3-C6) cycloalkyl, R 2 is optionally substituted at one ring atom by a spirocyclic oxindolyl group, L 2 is selected from a direct bond, -CH2-, and -CH2O-, and L 2 (when present) is optionally substituted by methyl, R 3 is selected from -H and halo, R 4 is -H, R 5is -H or methyl, X is CH or N, Y is CH or CF, E is selected from -C(O)- and -S(O)2-, n is 0, 1 or 2.

[0074] In an embodiment, the compound is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 is selected from -H, -(C1-C6)alkyl, -(C3-C7)cycloalkyl, -(C4-C8)cycloalkenyl, -(C6-C 10 )aryl, 4-10 membered heterocycloalkyl, 5-8 membered heterocycloalkenyl, and 5-10 membered heteroaryl, and R 1 is optionally substituted in one or more occurrences of R A , each R A is independently selected from halo, -OH, -NHR', -CN, oxo, -SO2CH3, -(C1-C3)alkyl, -O(C1-C3)alkyl, -C(O)R'', -NHC(O)R'', -(C3-C6)cycloalkyl, 3-6 membered heterocycloalkyl, phenyl, and pyridyl, and each occurrence of -(C1-C3)alkyl, -O(C1-C3)alkyl, and phenyl is optionally substituted by one or more groups independently selected from halo, -OH, and -NH2, and / or two occurrences of R A may together with the atoms to which they are attached form a (C3-C6)cycloalkyl group or a 3-6 membered heterocycloalkyl group, each R' is independently selected from -H and methyl, each R'' is independently selected from methyl and tetrahydrofuranyl, L 1 is selected from a direct bond and -CH2-, R 2 is selected from -(C3-C6)cycloalkyl, 5-10 membered heterocycloalkyl, -(C6-C 10 )aryl, and 5-10 membered heteroaryl, and R2 is optionally replaced by one or more occurrences of R B and each R is independently selected from halo, -OH, -NH2, -NO2, -CN, -SF5, -(C1-C3)alkyl, -O(C1-C3)alkyl, -(C3-C6)cycloalkyl, -SO2CH3, phenyl, benzyl, and 1-λ B -2-thiazolidine-1,1-dionyl, and each occurrence of -(C1-C3)alkyl, -O(C1-C3)alkyl, -(C3-C6)cycloalkyl, phenyl, and benzyl is optionally replaced by one or more groups independently selected from halo, -OH, -NH2, and -CF3 6 ; further, when R is -(C3-C6)cycloalkyl, R 2 is optionally replaced at one ring atom by a spirocyclic oxindolyl group 2 ; L is selected from a direct bond, -CH2-, and -CH2O-, and L 2 is optionally substituted by methyl when present 2 ; R is selected from -H and halo 3 ; R is -H 4 ; R is -H or methyl 5 ; X and Y are each independently selected from CH and N (with the proviso that Y is not N) ; E is selected from -C(O)- and -S(O)2- ; and n is 0, 1, or 2 ; in embodiments, the compound is a compound of formula (I-A)

[0075]

Chemical Formula

[0076] In an embodiment, the compound is of formula (I-B) [Chemical Formula] or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 5 , L 1 , and n are as defined herein.

[0077] In an embodiment, R 1 is selected from -H, -(C1-C6)alkyl, -(C3-C7)cycloalkyl, -(C4-C8)cycloalkenyl, -(C6-C 10 )aryl, 4-10 membered heterocycloalkyl, 5-8 membered heterocycloalkenyl, and 5-10 membered heteroaryl, R 1 is optionally substituted in one or more occurrences of R A , each R A is independently selected from halo, -OH, -NHR’, -CN, oxo, -SO2CH3, -(C1-C3)alkyl, -O(C1-C3)alkyl, -C(O)R’’, -NHC(O)R’’, -(C3-C6)cycloalkyl, 3-6 membered heterocycloalkyl, phenyl, and pyridyl, and each occurrence of -(C1-C3)alkyl, -O(C1-C3)alkyl, and phenyl is optionally substituted with one or more substituents independently selected from halo, -OH, and -NH2, and / or two occurrences of R A may together with the atoms to which they are attached form a (C3-C6)cycloalkyl group or a 3-6 membered heterocycloalkyl group, each R’ is independently selected from -H and methyl, and each R’’ is independently selected from -OH, methyl, and tetrahydrofuranyl.

[0078] In an embodiment, R 1 is selected from -H, -(C1-C3)alkyl, -(C3-C6)cycloalkyl, -(C5-C7)cycloalkenyl, -(C6-C 10)Selected from aryl, 4- to 9-membered heterocycloalkyl, 6-membered heterocycloalkenyl, 5- to 6-membered heteroaryl, and 9- to 10-membered heteroaryl, R 1 is optionally substituted in one or more occurrences of R A as defined herein.

[0079] In embodiments, R 1 is 6- to 10-membered polycyclic (e.g., bicyclic) heterocycloalkyl or 7- to 10-membered polycyclic (e.g., bicyclic) heteroaryl, and R 1 is optionally substituted by one or more occurrences of R A as defined herein.

[0080] In embodiments, R 1 is 6- to 10-membered polycyclic (e.g., bicyclic) heterocycloalkyl and is optionally substituted by one or more occurrences of R A as defined herein. In embodiments, R 1 is A 7- to 9-membered polycyclic (e.g., bicyclic) heterocycloalkyl optionally substituted in one or more occurrences of R 1 In embodiments, R 1 is 7- to 9-membered bicyclic heterocycloalkyl containing one or two (e.g., two) hetero ring atoms selected from nitrogen, oxygen, and sulfur, and R A is optionally substituted in one or more occurrences of R

[0081] In embodiments, R 1 is 7- to 10-membered polycyclic (e.g., bicyclic) heteroaryl and is optionally substituted in one or more occurrences of R A as defined herein. In embodiments, R 1 is 7- to 10-membered bicyclic heteroaryl containing one or two (e.g., two) hetero ring atoms selected from nitrogen, oxygen, and sulfur, and R 1 is A optionally substituted in one or more occurrences of R 1is a 9- or 10-membered bicyclic heteroaryl containing one or two (e.g., two) heteroatoms selected from nitrogen and sulfur, and R 1 is R A optionally substituted in one or more occurrences. In embodiments, R 1 is an 8- to 9-membered (e.g., 9-membered) polycyclic (e.g., bicyclic) heteroaryl, and R A is optionally substituted in one or more occurrences. In embodiments, R 1 is an unsubstituted 9-membered bicyclic heteroaryl.

[0082] In embodiments, R 1 is fully saturated. In other embodiments, R 1 is partially or fully unsaturated (e.g., a partially or fully unsaturated cyclic group). In embodiments, R 1 is selected from -(C4-C8) cycloalkenyl, 5- to 8-membered heterocycloalkenyl, -(C6-C 10 ) aryl, and 9- to 10-membered heteroaryl, and R 1 is optionally substituted in one or more occurrences of R A as defined herein. In embodiments, R 1 is -(C4-C8) cycloalkenyl or 5- to 8-membered heterocycloalkenyl, and R 1 is R A optionally substituted in one or more occurrences. In embodiments, R 1 is -(C6-C 10 ) aryl or 9- to 10-membered heteroaryl, and R 1 is R A optionally substituted in one or more occurrences. In embodiments, R 1 is 5- to 8-membered heterocycloalkenyl or 9- to 10-membered heteroaryl, and R 1 is R A optionally substituted in one or more occurrences. In embodiments, R 1 is -(C4-C8) cycloalkenyl or -(C6-C 10 ) aryl, and R 1 is R A optionally substituted in one or more occurrences.

[0083] In an embodiment, R 1 is selected from -(C4-C8) cycloalkenyl, -(C6-C 10 ) aryl, 7- to 10-membered polycyclic (e.g., bicyclic) heterocycloalkyl, 5- to 8-membered heterocycloalkenyl, and 7- to 10-membered polycyclic (e.g., bicyclic) heteroaryl, and R 1 is optionally substituted in one or more occurrences of R A as defined herein, or R 1 is -(C1-C6) alkyl substituted by one or more substituents selected from -OH, -NH2, and -O(C1-C3) alkyl.

[0084] In an embodiment, R 1 is

Chemical formula

Chemical formula

[0085] In an embodiment, R 1 is

Chemical formula

[0086] In embodiments, R 1 is

Chemical formula

Chemical formula

Chemical formula

[0087] In embodiments, R 1 is

Chemical formula

[0088] In embodiments, R 1 is -(C4-C6) cycloalkyl or 5- to 7-membered heterocycloalkyl, the heterocycloalkyl group contains one or two atoms independently selected from O and N, and the cycloalkyl or heterocycloalkyl group is optionally and independently substituted by one or more occurrences of R A defined above. In embodiments, each R A is independently selected from -OH, -NH2, -Me, difluoroethyl, and -OCH3.

[0089] In embodiments, R 1 is

Chemical formula

[0090] In other embodiments, R 1 is [Chemical formula] selected from

[0091] In an embodiment, L 1 is a direct bond or -CH2-. In an embodiment, L 1 is a direct bond. In another embodiment, L 1 is -CH2-.

[0092] In an embodiment, L 1 is a direct bond or -CH2-, and R 1 is -(C4-C6) cycloalkyl or 5-7 membered heterocycloalkyl, the heterocycloalkyl group contains one or two atoms independently selected from O and N, and the cycloalkyl or heterocycloalkyl group is optionally and independently substituted by one or more of the previously defined R A . In an embodiment, each R A is independently selected from -OH, -NH2, -Me, difluoroethyl, and -OCH3.

[0093] In an embodiment, L 1 is -CH2-, and R 1 is -(C3-C7) cycloalkyl, 4-10 membered heterocycloalkyl, or 5-10 membered heteroaryl, and R 1 is optionally substituted in one or more occurrences of R as defined herein A .

[0094] In an embodiment, when L 1が is -O-, R 1 is not -H.

[0095] In an embodiment, R 2 is selected from -(C3-C6) cycloalkyl, 5-10 membered heterocycloalkyl, -(C6-C 10 ) aryl, and 5-10 membered heteroaryl, and R 2 is optionally substituted in one or more occurrences of R B , and each R Bis selected from halo, -OH, oxo, -NH2, -NHMe, -NO2, -CN, -SF5, -SiMe3, -(C1-C3)alkyl, -O(C1-C3)alkyl, -(C3-C6)cycloalkyl, -O(C3-C6)cycloalkyl, -SO2CH3, -NHC(O)Me, -NHC(O)OC(CH3)3, phenyl, benzyl, and 1-λ 6 -2-thiazolidine-1,1-dionyl, and each occurrence of (C1-C3)alkyl, -O(C1-C3)alkyl, -(C3-C6)cycloalkyl, phenyl, and benzyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH2, and -CF3, and further, when R 2 is -(C3-C6)cycloalkyl, R 2 is optionally substituted by a spirocyclic oxindolyl group at one ring atom.

[0096] In embodiments, R 2 is selected from -(C3-C6)cycloalkyl, 5- to 6-membered heterocycloalkyl, 9- to 10-membered heterocycloalkyl, -(C6-C 10 )aryl, 5- to 6-membered heteroaryl, and 9- to 10-membered heteroaryl, and R 2 is optionally substituted at one or more occurrences of R B as defined herein.

[0097] In embodiments, R 2 is selected from -(C4-C6)cycloalkyl, -(C6-C 10 )aryl, and 5- to 10-membered heteroaryl, and R 2 is optionally substituted by one or more occurrences of R B as defined above. In embodiments, each R B is independently selected from the group consisting of halo, -NO2, -NH2, -OCH3, -OCF3, -SF5, -(C1-C3)alkyl optionally substituted by one or more halo, and -(C3-C6)cycloalkyl optionally substituted by -CF3.

[0098] In embodiments, R 2is selected from -(C5-C6) cycloalkyl, phenyl, and 6-9 membered heteroaryl, and R 2 is R B optionally substituted by one or more occurrences of each R B is independently selected from the group consisting of halo, -NO2, -NH2, -OCH3, -OCF3, -SF5, -(C1-C2) alkyl optionally substituted with one or more fluoros, and cyclopropyl optionally substituted with -CF3.

[0099] In an embodiment, R 2 is

Chemical formula

[0100] In an embodiment, R 2 is -(C3-C6) cycloalkyl optionally substituted by one or more occurrences of R B as defined herein, and further, R 2 is optionally substituted at one ring atom with a spirocyclic oxindolyl group.

[0101] In an embodiment, R B is selected from -NO2, -SF5, -SiMe3, -B(OH)2, -(C3-C6) cycloalkyl, -O(C3-C6) cycloalkyl, phenyl, and benzyl optionally substituted with one or more groups independently selected from halo, -OH, -NH2, and -CF3, and each occurrence of -(C3-C6) cycloalkyl and phenyl is substituted with one or more groups independently selected from halo, -OH, -NH2, and -CF3. In an embodiment, R B is not -O(C3-C6) cycloalkyl. In an embodiment, R B is not -O-cyclopropyl. In an embodiment, R Bis not -NHC(O)OC(CH3)3.

[0102] In an embodiment, at least one occurrence of R B is -SF5. In an embodiment, one occurrence of R B is -SF5. In an embodiment, R 2 is replaced by one occurrence of R B and R B is -SF5. In an embodiment, R 2 is replaced by two occurrences of R B one occurrence of R B is -SF5 and the other occurrence of R B is selected from -F, -OH, -NH2, -NHMe, and -NO2. In an embodiment, R 2 is replaced by two occurrences of R B one occurrence of R B is -SF5 and the other occurrence of R B is selected from -OH and -NH2. In an embodiment, R 2 is replaced by two occurrences of R B one occurrence of R B is -SF5 and the other occurrence of R B is -NH2.

[0103] In an embodiment, R 2 is phenyl substituted by one or two occurrences of R B and at least one occurrence of R B is -SF5. In an embodiment, R 2 is phenyl substituted by one or two occurrences of R B and one occurrence of R B is -SF5. In an embodiment, R 2 is phenyl substituted by one or two occurrences of R B and one occurrence of R B is -SF5 and the other occurrence of R B if any, is selected from -F, -OH, -NH2, -NHMe, and -NO2. In an embodiment, R 2 is R Bphenyl substituted by one or two occurrences of, R B one occurrence of is -SF5, R B the other occurrence (if any) of is selected from -OH and -NH2. In an embodiment, R 2 is, R B phenyl substituted by two occurrences of, R B one occurrence of is -SF5, R B the other occurrences of are selected from -F, -OH, -NH2, -NHMe and -NO2. In an embodiment, R 2 is, R B phenyl substituted by two occurrences of, R B one occurrence of is -SF5, R B the other occurrences of are selected from -OH and -NH2. In an embodiment, R 2 is, R B phenyl substituted by two occurrences of, R B one occurrence of is -SF5, R B the other occurrence of is -NH2. In an embodiment, R 2 is, R B phenyl substituted by one occurrence of, R B is -SF5.

[0104] In an embodiment, R 2 is,

Chemical formula

[0105] In the embodiment, R 2 is

Chem.

Chem.

Chem.

[0106] In the embodiment, R 2 is

Chem.

[0107] In the embodiment, R 2 is

Chem.

[0108] In the embodiment, R 2 is

Chem.

[0109] In the embodiment, R 2 is

Chem.

[0110] In the embodiment, R 2 is

Chem.

[0111] In an embodiment, R 2 is

Chemical formula

[0112] In another embodiment, R 2 is

Chemical formula

[0113] In an embodiment, R 2 is

Chemical formula

[0114] In an embodiment, R 2 is

Chemical formula

[0115] In another embodiment, R 2 is

Chemical formula

[0116] In another embodiment, R 2 is

Chemical formula

[0117] In an embodiment, L2 is selected from direct bond, -CH2-, and -CH2O-, and L 2 (when present) is methyl optionally substituted. In an embodiment, L 2is selected from a direct bond, unsubstituted -CH2-, and -CH2O- substituted with methyl.

[0118] In an embodiment, L 2 is a direct bond.

[0119] In an embodiment, L 2 is a direct bond, and R 2 is

Chemical formula

[0120] In an embodiment, L 2 is a direct bond, and R 2 is

Chemical formula

[0121] In an embodiment, L 2 is a direct bond, and R 2 is

Chemical formula

[0122] In an embodiment, L 2 is a direct bond, and R 2 is

Chemical formula

[0123] In an embodiment, L 2 is a direct bond, and R 2 is

Chemical formula

[0124] In an embodiment, L 2 is a direct bond, and R 2 is [Chemical formula] is.

[0125] In other embodiments, L 2 is a direct bond, and R 2 is [Chemical formula] is.

[0126] In an embodiment, L 2 is a direct bond, and R 2 is [Chemical formula] is.

[0127] In an embodiment, L 2 is a direct bond, and R 2 is [Chemical formula] is.

[0128] In other embodiments, L 2 is a direct bond, and R 2 is [Chemical formula] is.

[0129] In other embodiments, L 2 is a direct bond, and R 2 is [Chemical formula] is.

[0130] In an embodiment, R 3 is -H or halo (e.g., -F). In an embodiment, R 3 is halo (e.g., -F). In an embodiment, R 3is -F.

[0131] In an embodiment, R 3 is -H. In an embodiment, R 4は is -H. In an embodiment, R 3 and R 4は are both -H.

[0132] In an embodiment, R 3 is -H or halo (e.g., -F), and R 4 is -H. In an embodiment, R 3 is halo (e.g., -F), and R 4 is -H. In an embodiment, R 3 is -F, and R 4 is -H.

[0133] In an embodiment, R 5 is -H. In an embodiment, R 3 , R 4 and R 5 are all -H.

[0134] In some embodiments, R 5 is methyl.

[0135] In an embodiment, R 3 is halo (e.g., -F), R 4 is -H, and R 5 is -H. In an embodiment, R 3 is halo (e.g., -F), R 4 is -H, and R 5 is methyl. In an embodiment, R 3 is -F, R 4 is -H, and R 5は is -H. In an embodiment, R 3 is -F, R 4 is -H, and R 5 is methyl.

[0136] In an embodiment, X is N.

[0137] In the embodiment, Y is CH.

[0138] In the embodiment, Y is CF. In the embodiment, X is N and Y is CF.

[0139] In the embodiment, E is -C(O)- or -S(O)2-. In the embodiment, E is -C(O)-.

[0140] In the embodiment, n is 1. In the embodiment, n is 0 or 2. In the embodiment, n is 0. In the embodiment, n is 2.

[0141] In the embodiment, X is N and Y is CH. In the embodiment, X is N, Y is CH, and n is 1. In the embodiment, X is N, Y is CH, n is 1, and R 5は is -H.

[0142] In the embodiment, X is N and E is -C(O)-. In the embodiment, X is N, Y is CH, and E is -C(O)-.

[0143] In the embodiment, X is N, Y is CH, and R 5 is -H, n is 1, and E is -C(O)-.

[0144] In the embodiment, X is N, Y is CH, and n is 0. In the embodiment, X is N, Y is CH, n is 0, and R 5 is -H. In the embodiment, X is N, Y is CH, n is 0, E is -C(O)-, and L 2 is a direct bond, R 4 is -H, R 5 is -H. From this aspect, the present disclosure provides a compound of formula (I-C)

Chemical formula

[0145] In embodiments, X is N, Y is CH, and n is 2. In embodiments, X is N, Y is CH, and n is 2, and R 5 is -H. In embodiments, X is N, Y is CH, and n is 2, E is -C(O)-, and L 2 is a direct bond, and R 4 is -H, and R 5 is -H. In view of this aspect, the present disclosure provides a compound of formula (I-D)

Chemical formula

[0146] In embodiments, R 1 is cyclohexyl or 4- to 7-membered heterocycloalkyl, optionally substituted with one or more R A , each R A is independently selected from halo, (C1-C3)alkyl is optionally substituted with one or more halo, L 1 is a direct bond or -CH2-, and R 2 is

Chemical formula

[0147] In embodiments, the compound is of formula (II)

Chemical formula

[0148] In an embodiment, R 2 is selected from -(C4-C6) cycloalkyl, -(C6-C 10 ) aryl, and 5- to 10-membered heteroaryl, R 2 is optionally substituted by one or more occurrences of R B , each R Bis independently selected from the group consisting of halo, -NO2, -NH2, -OCH3, -OCF3, -SF5, -(C1-C3)alkyl optionally substituted with one or more halo, and -(C3-C6)cycloalkyl optionally substituted with -CF3.

[0149] In an embodiment, E is -C(O)-.

[0150] In an embodiment, the compound is of formula (III)

Chemical formula

[0151] In embodiments, R 2 is selected from -(C4-C6)cycloalkyl, (C6-C 10 )aryl, and 5- to 10-membered heteroaryl, and R 2 is optionally replaced by one or more occurrences of R B , and each R B is independently selected from the group consisting of halo, -NO2, -NH2, -OCH3, -OCF3, -SF5, (C1-C3)alkyl optionally substituted with one or more halo, and -(C3-C6)cycloalkyl optionally substituted with -CF3.

[0152] In embodiments, the compound is a compound of formula (III) or a pharmaceutically acceptable salt thereof, wherein R 1 is cyclohexyl or 4- to 7-membered heterocycloalkyl, optionally substituted with one or more R A , and each R A is independently selected from halo and (C1-C3)alkyl optionally substituted by one or more halo groups, L 1 is a direct bond or -CH2-, R 2is selected from -(C4-C6) cycloalkyl, (C6-C 10 ) aryl, and 5- to 10-membered heteroaryl, and R 2 is optionally substituted by one or more occurrences of R B , and each R B is independently selected from the group consisting of halo, -NO2, -NH2, -OCH3, -OCF3, -SF5, (C1-C3) alkyl optionally substituted with one or more halo, and -(C3-C6) cycloalkyl optionally substituted with -CF3.

[0153] In an embodiment, R 2 is

Chemical formula

[0154] In an embodiment, L 2 is a direct bond, and R 2 is

Chemical formula

[0155] In an embodiment, L 2 is a direct bond, and R 2 is

Chemical formula

[0156] In an embodiment, L 2 is a direct bond, and R 2 is

Chemical formula

[0157] In a further embodiment, L 2 is a direct bond, and R 2 is

Chemical formula

[0158] In an embodiment, R 2 is

Chemical formula

[0159] In an embodiment, R 2 is

Chemical formula

[0160] In an embodiment, R 2 is

Chemical formula

[0161] In other embodiments, R 2 is

Chemical formula

[0162] In an embodiment, the compound is a compound of formula (IV)

Chemical formula

[0163] In an embodiment, p is 1 or 2, and each R B is independently selected from the group consisting of halo, -NO2, -NH2, -OCH3, -OCF3, -SF5, -(C1-C3) alkyl optionally substituted with one or more halo, and -(C3-C6) cycloalkyl optionally substituted with -CF3.

[0164] In an embodiment, p is 1, 2 or 3. In an embodiment, p is 1 or 2. In an embodiment, p is 1. In other embodiments, p is 2. In other embodiments, p is 3.

[0165] In an embodiment, p is 1 or 2, and each R B is independently selected from halo, -OH, -OCF3, -NH2, -NHMe, -NHAc, and -SF5. In an embodiment, p is 1 or 2, and each R B is independently selected from halo, -OH, -OCF3, -NH2, and -SF5.

[0166] In an embodiment, each R B is independently selected from -OCF3, -NH2 and -SF5, and p is 1 or 2.

[0167] In an embodiment, p is 3, 4 or 5. In an embodiment, p is 3, 4 or 5, and at least one R B is halo (e.g., -F). In an embodiment, p is 4 or 5, and the four occurrences of R B are halo (e.g., -F). In an embodiment, p is 4 or 5, and the four occurrences of R B are -F.

[0168] In an embodiment, the compound is of formula (V) [Chemical formula] or a pharmaceutically acceptable salt thereof, wherein R 1 and L 1 are as defined above, R B1 is either -H or is selected from the group consisting of halo (e.g., -F or -Cl), -OH, -NH2, -NHMe, -NHAc, NHBoc, and -NO2, R B2 is selected from the group consisting of halo (e.g., -Br), -SF5, -SO2CH3, -SiMe3, -(C1-C3)alkyl optionally substituted with one or more halo groups, -O(C1-C3)alkyl optionally substituted with one or more halo groups, 1-trifluoromethylcyclopropan-1-yl, -O-cyclopropyl, and phenyl optionally substituted by one or more groups independently selected from halo, or -NH2.

[0169] In an embodiment, R B1 is either -H or is selected from the group consisting of -NH2 and -NO2, and R B2 is selected from the group consisting of -OCF3, -SF5, -CF2CF3, -CH2CF3, and 1-trifluoromethylcyclopropan-1-yl.

[0170] In an embodiment, R B1 is either -H or is selected from the group consisting of halo (e.g., -F), -NH2, -NHMe, -NHAc and -OH, and R B2 is selected from the group consisting of -OCF3 and -SF5.

[0171] In an embodiment, R B2 is -SF5. In an embodiment, R B1 is either -H or is selected from the group consisting of halo (e.g., -F), -NH2, -NHMe, -NO2 and -OH, and R B2 is -SF5. In an embodiment, R B1 is either -H or selected from the group consisting of halo (e.g., -F), -NH2, -NHMe, and -OH, and R B2 is -SF5.

[0172] In an embodiment, the compound is a compound of formula (VI) or (VII)

Chemical formula

[0173] In an embodiment, the compound is a compound of formula (VI) or a pharmaceutically acceptable salt thereof. In another embodiment, the compound is a compound of formula (VII) or a pharmaceutically acceptable salt thereof.

[0174] In an embodiment, the compound is a compound of formula (VI-A) or (VII-A)

Chemical formula

[0175] In an embodiment, L 1 is CH2. In another embodiment, L 1 is a direct bond.

[0176] In an embodiment, the compound is a compound of formula (VI-A) or a pharmaceutically acceptable salt thereof. In another embodiment, the compound is a compound of formula (VII-A) or a pharmaceutically acceptable salt thereof.

[0177] In an embodiment, the compound is of formula (VIII), (IX), or (X)

Chemical formula

[0178] In embodiments, the compound is a compound of formula (VIII) or a pharmaceutically acceptable salt thereof. In other embodiments, the compound is a compound of formula (IX) or a pharmaceutically acceptable salt thereof. In other embodiments, the compound is a compound of formula (X) or a pharmaceutically acceptable salt thereof.

[0179] In embodiments, the compound is of formula (VIII-A), (IX-A), or (X-A)

Chemical formula

[0180] In embodiments, the compound is a compound of formula (VIII-A) or a pharmaceutically acceptable salt thereof. In other embodiments, the compound is a compound of formula (IX-A) or a pharmaceutically acceptable salt thereof. In other embodiments, the compound is a compound of formula (X-A) or a pharmaceutically acceptable salt thereof.

[0181] In embodiments, the compound is as defined herein (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof), provided that when R B is -O(C3-C6) cycloalkyl or -NHBoc, R 1 is not -(C3-C6) cycloalkyl or 4-6 membered monocyclic heterocycloalkyl. In embodiments, the compound is as defined herein (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof), provided that when R B is -O-cyclopropyl or -NHBoc, R 1is not cyclopropyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl or piperidinyl. In embodiments, the compound is as defined herein (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof), provided that R B when is -O-cyclopropyl, R 1 is [Chemical formula] is not. In embodiments, the compound is as defined herein (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof), provided that R B when is -NHBoc, R 1 is [Chemical formula] is not.

[0182] In embodiments, the compound (e.g., a compound of formula (I)) is not as defined in WO 2022 / 187518 A1. In embodiments, the compound (e.g., a compound of formula (I)) is not one or more (e.g., any) of the compounds exemplified in WO 2022 / 187518 A1.

[0183] In embodiments, the compound (e.g., a compound of formula (I)) is not one or more (e.g., any) of the following. -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -5-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one, -[4-(3H-Imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-[(2R)-Morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -5-[7-[1-[2-Amino-4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(6-fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(2-Amino-4-trifluoromethoxyphenyl)[4-(3H-1,3,4-triazainden-7-yl)-1-piperidyl]methanone; -(1-Phenyl-4-pyrazolyl)[4-(3H-1,3,4-triazainden-7-yl)-1-piperidyl]methanone; -(2-Amino-4-trifluoromethoxyphenyl)[4-(2-cyclopropyl-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -5-{7-[1-(2-Amino-4-trifluoromethoxybenzoyl)-4-piperidyl]-imidazo[4,5-b]pyridin-2-yl}-2-piperidinone; -(2-Amino-4-chlorophenyl){4-[2-(2-morpholinyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -5-{7-[1-(2-Amino-4-chlorobenzoyl)-4-piperidyl]-3H-1,3,4-triazaindene-2-yl}-2-piperidinone; -(2-Amino-4-chlorophenyl){4-[2-(3-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -6-{7-[1-(4-Trifluoromethoxy-benzoyl)-4-piperidyl]-imidazo[4,5-b]pyridin-2-yl}-3-morpholinone; -6-{7-[1-(2-Amino-4-chlorobenzoyl)-4-piperidyl]-3H-1,3,4-triazaindene-2-yl}-3-morpholinone; -3-({4-[2-(Tetrahydro-2H-pyran-4-yl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}carbonyl)-6-(trifluoromethyl)-2(1H)-pyridinone; -(2-Amino-4-trifluoromethoxyphenyl){4-[2-(1-methyl-3-pyrrolidinyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -6-{7-[1-(2-Amino-4-trifluoromethoxy-benzoyl)-4-piperidyl]-imidazo[4,5-b]pyridin-2-yl}-3-morpholinone; -(2-Amino-4-trifluoromethoxyphenyl){4-[6-fluoro-2-(1-methyl-4-pyrazolyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -(2-Amino-4-chlorophenyl){4-[6-fluoro-2-(1-methyl-4-pyrazolyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -5-{7-[1-(2-Amino-4-chlorobenzoyl)-4-piperidyl]-6-fluoro-3H-1,3,4-triazaindol-2-yl}-2-piperidinone; -6-{7-[1-(2-Amino-4-trifluoromethoxybenzoyl)-4-piperidyl]-6-fluoro-imidazo[4,5-b]pyridin-2-yl}-3-morpholinone; -3-{[4-(6-Fluoro-3H-1,3,4-triazaindol-7-yl)-1-piperidyl]carbonyl}-6-(trifluoromethyl)-2(1H)-pyridinone; -3-({4-[6-Fluoro-2-(tetrahydro-2H-pyran-4-yl)-3H-1,3,4-triazaindol-7-yl]-1-piperidyl}carbonyl)-6-(trifluoromethyl)-2(1H)-pyridinone; -4-{[4-(6-Fluoro-3H-1,3,4-triazaindol-7-yl)-1-piperidyl]carbonyl}-1-(2,2,2-trifluoroethyl)-2(1H)-pyridinone; -3-{[4-(6-Fluoro-3H-1,3,4-triazaindol-7-yl)-1-piperidyl]carbonyl}-1-methyl-6-(trifluoromethyl)-2(1H)-pyridinone; -{4-[6-Fluoro-2-(1-methyl-4-pyrazolyl)-3H-1,3,4-triazaindol-7-yl]-1-piperidyl}(p-trifluoromethoxyphenyl)methanone; -(2-Amino-4-trifluoromethoxyphenyl){4-[6-fluoro-2-(3-piperidyl)-3H-1,3,4-triazaindol-7-yl]-1-piperidyl}methanone; -(2-Amino-4-chlorophenyl){4-[6-fluoro-2-(3-piperidyl)-3H-1,3,4-triazaindol-7-yl]-1-piperidyl}methanone; -(2-Amino-4-trifluoromethoxyphenyl){4-[6-fluoro-2-(2-morpholinyl)-3H-1,3,4-triazaindol-7-yl]-1-piperidyl}methanone; -(2-Amino-4-chlorophenyl){4-[6-fluoro-2-(2-morpholinyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -6-{7-[1-(2-Amino-4-chlorobenzoyl)-4-piperidyl]-6-fluoro-3H-1,3,4-triazaindene-2-yl}-3-morpholinone; -(2-Amino-4-chloro-5-fluorophenyl){4-[6-fluoro-2-(1-methyl-4-pyrazolyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -4-{7-[1-(2-Amino-4-trifluoromethoxy-benzoyl)-4-piperidyl]-6-fluoro-imidazo[4,5-b]pyridin-2-yl}-1λ6-1,1-thiandione; -{4-[6-Fluoro-2-(tetrahydro-2H-pyran-4-yl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}(4-trifluoromethoxyphenyl)methanone; -(6-Indolyl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -{4-[6-Fluoro-2-(3-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}(4-trifluoromethoxyphenyl)methanone; -1-(4-{7-[1-(2-Amino-4-trifluoromethoxy-benzoyl)-4-piperidyl]-6-fluoro-imidazo[4,5-b]pyridin-2-yl}-1-piperidyl)-1-ethanone; -(2-Amino-4-trifluoromethoxyphenyl){4-[6-fluoro-2-(4-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -(2-Amino-4-chloro-5-fluorophenyl){4-[6-fluoro-2-(1-methyl-4-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -(2-Amino-4-chloro-5-fluorophenyl){4-[6-fluoro-2-(4-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -(2-Amino-4-chloro-5-fluorophenyl){4-[6-fluoro-2-(3-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -(2-Amino-4-trifluoromethoxyphenyl){4-[6-fluoro-2-(3-fluoro-1-methyl-4-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -(2-Amino-4-trifluoromethoxyphenyl){4-[6-fluoro-2-(1-methyl-4-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -{4-[6-Fluoro-2-(3-oxetanyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}(p-trifluoromethoxyphenyl)methanone; -{4-[6-Fluoro-2-(2-morpholinyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}(p-trifluoromethoxyphenyl)methanone; -{4-[6-Fluoro-2-(4-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}(p-trifluoromethoxyphenyl)methanone; -7-[1-(2-Amino-4-chlorobenzoyl)-4-piperidyl]-1,3-dihydro-1,3,4-triaza-2-indenone; -7-[1-(4-Trifluoromethoxy-benzoyl)-4-piperidyl]-imidazo[4,5-b]pyridin-2-one; -7-[1-(2-Amino-4-trifluoromethoxy-benzoyl)-4-piperidyl]-imidazo[4,5-b]pyridin-2-one; -(6-Indolyl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -(1-Methyl-1H-indazol-5-yl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -(4-Amino-3-methyl-5-isothiazolyl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -(5-Bromo-2-pyrimidinyl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -(4-Hydroxy-7-methyl-1,8-diaza-3-naphthyl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -[4-(3H-1,3,4-Triazaindene-7-yl)-1-piperidyl][5-(trifluoromethyl)-3-pyrazolyl]methanone; -(3-Amino-4-bromo-5-fluorophenyl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -[1-(tert-Butyl)-3-pyrrolyl][4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -(1-Methyl-4-imidazolyl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -7-[1-(2-Naphthylsulfonyl)-4-piperidyl]-3H-1,3,4-triazaindene; -7-[1-(4-Methoxyphenylsulfonyl)-4-piperidyl]-3H-1,3,4-triazaindene; -7-[1-(5-Methyl-2-thienylsulfonyl)-4-piperidyl]-3H-1,3,4-triazaindene; -7-{1-[m-(Trifluoromethyl)phenylsulfonyl]-4-piperidyl}-3H-1,3,4-triazaindene; -(6-Methyl-2-naphthyl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -(3-Amino-2-naphthyl){4-[2-(trifluoromethyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -(5-Cyclopentyl-2-thienyl)[4-(3H-1,3,4-triazaindene-7-yl)-1-piperidyl]methanone; -7-{1-[(3-Quinolyl)carbonyl]-4-piperidyl}-1,3-dihydro-1,3,4-triaza-2-indenone; -7-{1-[(6-Isoquinolyl)carbonyl]-4-piperidyl}-1,3-dihydro-1,3,4-triaza-2-indenone; -7-{1-[(2-Quinolyl)carbonyl]-4-piperidyl}-1,3-dihydro-1,3,4-triaza-2-indenone; -7-{1-[(1,3-Benzothiazol-6-yl)carbonyl]-4-piperidyl}-1,3-dihydro-1,3,4-triaza-2-indenone; -7-[1-(5-Ethyl-2-thenoyl)-4-piperidyl]-1,3-dihydro-1,3,4-triaza-2-indenone; -7-[3-Hydroxy-1-(5-isopropyl-3-thenoyl)-4-piperidyl]-1,3-dihydro-1,3,4-triaza-2-indenone; -7-[1-(2,4-Difluoro-3-anisoyl)-4-piperidyl]-1,3-dihydro-1,3,4-triaza-2-indenone; -7-{1-[(2-Methyl-1,3-thiazol-5-yl)carbonyl]-4-piperidyl}-1,3-dihydro-1,3,4-triaza-2-indenone; -7-{1-[(3-Methoxy-5-isoxazolyl)carbonyl]-4-piperidyl}-1,3-dihydro-1,3,4-triaza-2-indenone; -7-[1-(2-Hydroxy-4,6-dimethyl-nicotinoyl)-4-piperidyl]-1,3-dihydro-1,3,4-triaza-2-indenone; -6-Fluoro-7-{1-[(2-methyl-1H-1,3-benzimidazol-6-yl)carbonyl]-4-piperidyl}-1,3-dihydro-1,3,4-triaza-2-indenone; -2-[4-(2-oxo-1,3-dihydro-1,3,4-triaza-7-indenyl)-1-piperidylsulfonyl]benzonitrile; -7-[1-(phenylsulfonyl)-4-piperidyl]-1,3-dihydro-1,3,4-triaza-2-indenone; -7-{1-[(4-oxo-3-1H-quinolyl)carbonyl]-4-piperidyl}-1,3-dihydro-1,3,4-triaza-2-indenone; -7-[1-(5-cyclopropyl-2-tenoyl)-4-piperidyl]-1,3-dihydro-1,3,4-triaza-2-indenone; and -7-(1-{[1-(4-pyridyl)-3-pyrazolyl]carbonyl}-4-piperidyl)-1,3-dihydro-1,3,4-triaza-2-indenone.

[0184] In embodiments, the compound (e.g., a compound of formula (I)) is not one or more (e.g., any) of the following. -(2-amino-4-cyclopropoxyphenyl){4-[6-fluoro-2-(1-methyl-3-piperidyl)-3H-1,3,4-triazainden-7-yl]-1-piperidyl}methanone; -(2-amino-4-cyclopropoxyphenyl){4-[6-fluoro-2-(3-piperidyl)-3H-1,3,4-triazainden-7-yl]-1-piperidyl}methanone; -(4-cyclopropoxyphenyl){4-[6-fluoro-2-(4-piperidyl)-3H-1,3,4-triazainden-7-yl]-1-piperidyl}methanone; -(4-cyclopropoxyphenyl){4-[6-fluoro-2-(1-methyl-4-piperidyl)-3H-1,3,4-triazainden-7-yl]-1-piperidyl}methanone; -(2-Amino-4-cyclopropoxyphenyl){4-[6-fluoro-2-(4-piperidyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -(4-Cyclopropoxyphenyl){4-[6-fluoro-2-(tetrahydro-3-furyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -(4-Cyclopropoxyphenyl){4-[6-fluoro-2-(3-oxetanyl)-3H-1,3,4-triazaindene-7-yl]-1-piperidyl}methanone; -tert-Butyl N-(2-[4-[2-(oxan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]piperidine-1-carbonyl]-5-(trifluoromethoxy)phenyl)carbamate; and -tert-Butyl N-[2-(4-[2-cyclopropyl-3H-imidazo[4,5-b]pyridin-7-yl]piperidine-1-carbonyl)-5-(trifluoromethoxy)phenyl]carbamate.

[0185] In embodiments, the compound is -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -trans-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -cis-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -cis-[4-[2-(4-Aminocyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -1-[3-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]azetidin-1-yl]ethanone, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(1-Methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Methyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(3-Methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -5-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one, -[4-(Trifluoromethoxy)phenyl]-[4-[2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-(3H-Imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(Oxetan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2,2-dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(Azetidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(1-Methylpyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(6,6-dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(2,2-Dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(6,6-Dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(1,4-Dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(4-Methylmorpholin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(5,5-difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1-(2,2-difluoroethyl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-[1-(2,2-Difluoroethyl)azetidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(Oxetan-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(4-Chloro-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[2-Nitro-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(Tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(Oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(2-Oxaspiro[3.3]heptan-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(1,1,2,2,2-Pentafluoroethyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-(Pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(cis)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)cyclohexyl]methanone, -(trans)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)cyclohexyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-oxaspiro[3.3]heptan-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxetan-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(4-Methoxy-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -6-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-3-(trifluoromethyl)-1H-pyridin-2-one, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)phenyl]methanone, -[4-(Trifluoromethoxy)phenyl]-[4-[2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-(2-Tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(3-Methoxy-1-bicyclo[1.1.1]pentanyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]methanone, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]methanone, -[4-[2-(5,5-Difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydropyran-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-(2-Pyrrolidin-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-[(1-Methyl-4-piperidyl)methyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(Tetrahydropyran-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, and -[4-[2-[1-(2,2-Difluoroethyl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, and is selected from the group consisting of those and their pharmaceutically acceptable salts.

[0186] In an embodiment, the compound is -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(4-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -trans-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -cis-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -cis-[4-[2-(4-Aminocyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -1-[3-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]azetidin-1-yl]ethanone, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(1-Methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Methyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(3-Methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(trifluoromethoxy)phenyl]-[4-[2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(Oxetan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2,2-dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(Azetidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(1-Methylpyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(6,6-dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(2,2-dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(6,6-Dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(1,4-Dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(4-Methylmorpholin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(5,5-difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1-(2,2-difluoroethyl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-[1-(2,2-difluoroethyl)azetidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(Oxetan-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(4-Chloro-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[2-Nitro-4-(pentafluoro-λ 6-[4-(Sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(Tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-(Oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(2-Oxaspiro[3.3]heptane-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(1,1,2,2,2-Pentafluoroethyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-(Pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(cis)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)cyclohexyl]methanone, -(trans)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)cyclohexyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-oxaspiro[3.3]heptan-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxetan-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(4-Methoxy-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -6-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-3-(trifluoromethyl)-1H-pyridin-2-one, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)phenyl]methanone, -[4-(Trifluoromethoxy)phenyl]-[4-[2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-(2-Tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(3-Methoxy-1-bicyclo[1.1.1]pentanyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]methanone, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]methanone, -[4-[2-(5,5-Difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydropyran-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-(2-Pyrrolidin-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-[2-[(1-Methyl-4-piperidyl)methyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-[2-(tetrahydropyran-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(2-Tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, and -[4-[2-[1-(2,2-Difluoroethyl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, and is selected from the group consisting of pharmaceutically acceptable salts thereof.

[0187] In an embodiment, the compound is -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxetan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[Tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[Pyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -2-Naphthyl-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -1H-Indazol-3-yl-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]methanone; -(1-Methyl-5-phenyl-pyrazol-3-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(3-Amino-2-naphthyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(2-Amino-3,4,5,6-tetrafluoro-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[1-Isopropyl-2-(trifluoromethyl)benzimidazol-5-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(2-Amino-4-methylsulfonyl-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[3-(1,1-Dioxo-1,2-thiazolidin-2-yl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-(3-Hydroxyphenyl)cyclopropyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -2-[2-Chloro-4-(trifluoromethyl)phenoxy]-1-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]propan-1-one; -(3-Phenylcyclopentyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-Hydroxy-1-[2-(trifluoromethyl)phenyl]pyrazol-3-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[5,5-Difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[3-Amino-4-phenyl-5-(trifluoromethyl)-2-thienyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(7-Hydroxy-1H-indol-2-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(1-Cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -1-[4-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1-piperidyl]ethanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)cyclohexyl]methanone; -1-[4-[7-[1-[2-Amino-4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1-piperidyl]ethanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-Cyclohexyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1,4-dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -2-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]benzothiophene-5-carbonitrile; -(5-Amino-1-phenyl-pyrazol-4-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -2-[2-Oxo-2-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]ethyl]-4H-1,4-benzoxazin-3-one; -1-(3,4-Difluorophenyl)-4-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]pyrrolidin-2-one; -[4-(3-Chloro-4-fluoro-phenyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(7-Amino-2-methyl-pyrazolo[1,5-a]pyrimidin-6-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -1-[(2-Chlorophenyl)methyl]-4-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]pyrrolidin-2-one; -1-(4-Fluorophenyl)-4-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]pyrrolidin-2-one; -[1-[(2-Chlorophenyl)methyl]pyrazol-4-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Aminophenyl)phenyl]-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(3,6-Dichloroimidazo[1,2-a]pyridin-2-yl)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(4-Amino-1-ethyl-pyrazol-3-yl)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(3-Aminoquinoxalin-2-yl)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -2-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]spiro[cyclopropane-1,3'-indoline]-2'-one; -[1-(2-Chlorophenyl)pyrrolidin-3-yl]-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(2-Amino-4,5-dichloro-phenyl)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[1-(4-Fluorophenyl)imidazol-4-yl]-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-hydroxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-cyclohexyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxypropyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(3-Amino-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Amino-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -(trans)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)cyclohexyl]methanone; -[3-Fluoro-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(4-Methylpiperazin-1-yl)methyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[2-(5-chloro-2-hydroxy-phenyl)thiazol-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-fluoro-5-hydroxy-phenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -N-[3-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]phenyl]tetrahydrofuran-2-carboxamide; -[4-[2-[5-(hydroxymethyl)isoxazol-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -1-ethyl-3-hydroxy-6-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]quinoxalin-2-one; -[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-amino-4-(trifluoromethoxy)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -(4-bromophenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1,4-dioxan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -4-[7-[1-[2-amino-4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]cyclohexanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-(4-trimethylsilylphenyl)methanone; -(cis)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(trans)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(2,2-Difluoro-1,3-benzodioxol-5-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(4-Bromo-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-(trifluoromethyl)-1H-indol-6-yl]methanone; -[4-(Cyclopropoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[5,5-difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -2-Tetrahydropyran-4-yl-7-[1-[4-(trifluoromethoxy)phenyl]sulfonyl-4-piperidyl]-3H-imidazo[4,5-b]pyridine; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[rac-(2R,3S)-3-Aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[3-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-methylmorpholin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(7-Oxa-4-azaspiro[2.5]octan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[6,6-dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[6,6-dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[1-(Oxetan-3-yl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-(2-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-amino-4-(trifluoromethoxy)phenyl]-[4-[2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1-(oxetan-3-yl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-3-fluoro-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[rac-(2R,3S)-3-aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -(cis)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)cyclohexyl]-[4-(trifluoromethoxy)-1-piperidyl]methanone; -(trans)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)cyclohexyl]-[4-(trifluoromethoxy)-1-piperidyl]methanone; -[4-[2-(4-Amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -(trans)-[4-[2-(3-Methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(7-oxa-4-azaspiro[2.5]octan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-Cyclopent-3-en-1-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(2-Amino-4-bromo-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(4-Amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -N-[2-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-5-(trifluoromethoxy)phenyl]acetamide; -(trans)-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1,2,3,6-tetrahydropyridin-5-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[4-phenylpyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[4-fluoropyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-amino-3,3,3-trifluoro-propyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[6-(aminomethyl)-3-pyridyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[rac-(3R,4S)-4-(4-pyridyl)pyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-amino-2-bicyclo[2.2.1]hept-5-enyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[pyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Amino-2-thienyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -4-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidine-4-carbonitrile; -[4-[2-[2-Piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4-Aminotetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Amino-4-methoxy-phenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[Pyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1,2,3,4-Tetrahydroisoquinolin-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Amino-5-hydroxy-phenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1H-Indol-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4,5,6,7-Tetrahydrothieno[3,2-c]pyridin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(Azetidin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; 2,2,2-Trifluoroacetic acid -[4-[2-(3-Oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4-Amino-3-pyridyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[Piperazin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Aminocyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[3-(Methylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-Azabicyclo[4.1.0]heptan-7-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[4-Hydroxy-6-(trifluoromethyl)-3-quinolyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Oxabicyclo[3.1.0]hexan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -N-[4-Hydroxy-2-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]phenyl]acetamide; -5,6-Dimethyl-3-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1H-pyridin-2-one; -1-[3,5-Dimethyl-4-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1H-pyrrol-2-yl]ethanone; -[4-[2-[1-(1,1-Dioxothiolan-3-yl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1-Methylsulfonylazetidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Hydroxy-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(1,4-Oxazepan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[4-Hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-(1,1,2,2-Tetrafluoroethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(1,1,2,2,2-Pentafluoroethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Phenyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(2,2,3,3-Tetrafluoro-1,4-benzodioxin-6-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[4-Hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[7-oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[rac-(1S,3S)-3-Aminocyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-(2-Cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4-Methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[7-Oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-cyclopent-3-en-1-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(Azepan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[4-Amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(3-Hydroxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[rac-(1R,3S)-3-Aminocyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[4-[2-(3-Fluoro-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1,2,3,6-Tetrahydropyridin-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -3-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]bicyclo[1.1.1]pentane-1-carboxylic acid; -3-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-6-(trifluoromethyl)-1H-pyridin-2-one; -[4-(Difluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1,1-dioxothiolan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[1,4-Oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1,4-oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -(trans)-4-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]cyclohexanecarboxylic acid; -(cis)-[4-[2-[3-Aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1,1-Dioxothiolan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(4-Hydroxy-4-methyl-cyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(4-Hydroxy-4-methyl-cyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1,2,3,6-Tetrahydropyridin-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[Azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[Azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6-[4-(Pentafluoro-λ -sulfanyl)phenyl]-[4-(2-cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; 6 -[4-(Pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[2-amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-(2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; 6 -(cis)-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -(trans)-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ -sulfanyl)phenyl]methanone; 6 -[2-amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; 6 -(cis)-[2-amino-4-(pentafluoro-λ -sulfanyl)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; 6 -(trans)-[2-amino-4-(pentafluoro-λ -[4-(pentafluoro-λ 6-sulfanyl)phenyl]-[4-[2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; hydrochloride; -[4-[2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-N-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6-Sulfanyl)phenyl]-[4-[2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-(2-N-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(trans)-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[4-[2-(1-cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[4-[2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -(cis)-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6-Sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-(1-cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[2-(Methylamino)-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[4-[2-[4-methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[2-[4-methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[4-[2-[2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ6 -sulfanyl)phenyl]-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -3-methyl-3-[7-[1-[4-(pentafluoro-λ 6 -sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]cyclobutanone; -[4-[2-(1-hydroxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(1-hydroxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[(cis)-2-methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[(trans)-2-methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(trifluoromethoxy)phenyl]-[4-fluoro-4-(6-fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(3-Hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(3-hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[2-Hydroxy-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[(cis)-2-methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[(trans)-2-methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(Pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(6-Fluoro-2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(cis)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Fluoro-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(trans)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(cis)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-(6-Fluoro-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[6-Methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(6-Fluoro-2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[4-(hydroxymethyl)-1-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[4-[6-Fluoro-2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[2-[3-Methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-(6-Fluoro-2-thiomorpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-[6-methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -5-[6-Fluoro-7-[1-[4-(pentafluoro-λ 6 -sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one; -(trans)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-cyclopentyl-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ6 -[sulfanyl)phenyl]-[4-[6-fluoro-2-[oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-fluoro-2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-(3-hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-cyclopentyl-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[6-Fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-5-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(1-Cyclopropyl-4-piperidyl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(6-Fluoro-2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[6-Fluoro-2-[tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(trans)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[6-Fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(trans)-(4-(6-Fluoro-2-(4-hydroxy-4-methylcyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl)piperidin-1-yl)(4-(pentafluoro-λ6-sulfanyl)phenyl)methanone; -(cis)-[4-[6-Fluoro-2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[4-[6-Fluoro-2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -4-(6-Fluoro-2-N-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(trans)-[4-[6-Fluoro-2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(3,4,4a,5,7,7a-Hexahydro-2H-furo[3,4-b][1,4]oxazin-2-yl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6-sulfanyl)phenyl]methanone; -(trans)-[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -2-[6-fluoro-7-[1-[4-(pentafluoro-λ6-sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-2,3,4a,5,7,7a-hexahydrofuro[3,4-b][1,4]oxazine-4-carboxylic acid; -[4-[2-(1,1-dioxo-1,4-thiazinan-2-yl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(2-amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; and -7-[6-Fluoro-7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-2-oxa-5-azaspiro[3.5]nonane-5-carboxylic acid, and is selected from the group consisting of pharmaceutically acceptable salts thereof.

[0188] In embodiments where the compound has an enantiomeric form (e.g., when the compound has a chiral center, e.g., a chiral carbon atom), the compound exists as a racemic mixture of enantiomers. In embodiments where the compound has a chiral center (e.g., a chiral carbon atom), the compound exists as the (R) isomer. In other embodiments where the compound has a chiral center (e.g., a chiral carbon atom), the compound exists as the (S) isomer. Thus, in embodiments, the compound is -(R)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(S)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(R)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(S)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(rac)-5-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2,2-dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(R)-[4-(2-Morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(S)-[4-(2-Morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(R)-[4-[2-(1-Methylpyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(S)-[4-[2-(1-Methylpyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(R)-[4-(2-Tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(S)-[4-(2-Tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(6,6-dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-Morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(rac)-[4-[2-(2,2-Dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-[2-(6,6-Dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(R)-[4-[2-(1,4-Dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(S)-[4-[2-(1,4-Dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-(2-Tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-[2-(4-Methylmorpholin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(5,5-Difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(rac)-[4-[2-(Tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-[2-(Oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(rac)-[4-(2-Tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(rac)-[4-[2-(5,5-Difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-(2-Pyrrolidin-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, and -(rac)-[4-(2-Tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, and is selected from the group consisting of pharmaceutically acceptable salts thereof.

[0189] In an embodiment, the compound is -(R)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(S)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2,2-dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(R)-[4-[2-(1-Methylpyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(S)-[4-[2-(1-Methylpyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(R)-[4-(2-Tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(S)-[4-(2-Tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(6,6-dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(rac)-[4-[2-(2,2-dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-[2-(6,6-dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(R)-[4-[2-(1,4-Dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(S)-[4-[2-(1,4-Dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-(2-Tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-[2-(4-Methylmorpholin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(5,5-difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(rac)-[4-[2-(Tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-[2-(Oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(Oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(rac)-[4-(2-Tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(rac)-[4-[2-(5,5-Difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[4-(2-Pyrrolidin-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, and -(rac)-[4-(2-Tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, and is selected from the group consisting of pharmaceutically acceptable salts thereof.

[0190] In an embodiment, the compound is -[4-[2-[(2R)-Tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(2S)-Tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(3R)-Pyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(3S)-Pyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2R)-tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2S)-tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(3R)-5,5-Difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(3S)-5,5-Difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1,4-dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(rac)-[3-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2R)-1,4-dioxan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2S)-1,4-dioxan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(3R)-5,5-difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(3S)-5,5-difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[(3R)-3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[(3S)-3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(4R)-oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(4S)-oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[(3S)-3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[(3R)-3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-methylmorpholin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(2S)-6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(2R)-6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2R)-tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2S)-tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(rac)-[4-[2-(7-Oxa-4-azaspiro[2.5]octan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2S)-6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2R)-6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(3R)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(3S)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(rac)-[4-[2-(4-Amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -(rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(7-oxa-4-azaspiro[2.5]octan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(rac)-[4-[2-(4-Amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(3R,4S)-4-Phenylpyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(2R,4S)-4-Fluoropyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[4-[2-(2-Amino-3,3,3-trifluoro-propyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(2S)-Pyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(2R)-2-Piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[4-[2-(2-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(2R)-Pyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[4-[2-(Azetidin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[4-[2-(3-Oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(2R)-Piperazin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[4-[2-(2-Azabicyclo[4.1.0]heptan-7-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[4-[2-(3-Oxabicyclo[3.1.0]hexan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone -(rac)-[4-[2-(1,4-Oxazepan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(6S)-7-oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(6R)-7-oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(6R)-7-oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(6S)-7-oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[4-[2-(azepan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone -[4-[2-[(3S)-4-amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(3R)-4-amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -(rac)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -(rac)-[2-amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -(rac)-[4-[2-(3-fluoro-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(3S)-1,1-dioxothiolan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(3R)-1,1-dioxothiolan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(2R)-1,4-oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(2S)-1,4-oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2R)-1,4-oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(2S)-1,4-oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[(4R)-4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[(4S)-4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[(4R)-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[(4S)-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[4-[2-[(2R,3S)-3-Aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(2S,3R)-3-Aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; -(rac)-[4-[2-(1,1-Dioxothiolan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(3S)-Azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[(3R)-Azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(3S)-azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[(3R)-azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(rac)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(rac)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[4-(pentafluoro-λ6 -sulfanyl)phenyl]-[4-[2-[(2S)-tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(2R)-tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(3R)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(3S)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(2R)-morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(3R)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(3S)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(2S)-morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6-Sulfanyl)phenyl]-[4-[2-[(2S)-morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(2S)-4-Methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[4-[2-[(2R)-morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(2R)-4-Methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[(4S)-4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]-[(4R)-4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[4-[2-[(1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[(2R,4R)-2-Methyl-4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -Sulfanyl)phenyl]methanone; -[(2S,4S)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[(2R,4S)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[(2S,4R)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(rac)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -(rac)-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[(2S,4S)-2-methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6-[(2R,4R)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -[(2S,4R)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -[(2R,4S)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -[(4S)-4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -[(4R)-4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -[(3R)-3-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -[(3S)-3-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(Pentafluoro-λ 6 -[(3R)-3-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(Pentafluoro-λ 6 -sulfanyl)phenyl]-[(3S)-3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -(rac)-[4-(6-Fluoro-2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-[4-(6-Fluoro-2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(rac)-[4-(6-Fluoro-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(rac)-[4-[6-Fluoro-2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[(2R,6R)-6-Methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(rac)-[4-(6-Fluoro-2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(rac)-[4-(6-Fluoro-2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[2-[(1R,3R)-3-Methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[2-[(1S,3S)-3-Methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ6 -sulfanyl)phenyl]methanone; -[4-[2-[(1S,3R)-3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[2-[(1R,3S)-(3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-[4-(6-fluoro-2-thiomorpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-[(3S)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-[(3R)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-[(2R,6R)-6-methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[(3S)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6-sulfanyl)phenyl]-[4-[6-fluoro-2-[(3R)-tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-fluoro-2-[(2R)-morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-[(2S)-morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-5-[6-fluoro-7-[1-[4-(pentafluoro-λ 6 -sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(1R,3S)-3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(1S,3R)-3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(1R,3R)-3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[2-[(1S,3S)-3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[(4S)-oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-[(4R)-oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[(4S)-oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[(4R)-oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[(2R)-tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[(2S)-tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[(2R)-tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-[(2S)-tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6-sulfanyl)phenyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[(2R)-tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-amino-4-(pentafluoro-λ 6 -sulfanyl)phenyl]-[4-[6-fluoro-2-[(2S)-tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(rac)-[4-(6-fluoro-2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-[(2R)-tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -[4-[6-fluoro-2-[(2S)-tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-[4-[2-(3,4,4a,5,7,7a-hexahydro-2H-furo[3,4-b][1,4]oxazin-2-yl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; -(rac)-2-[6-fluoro-7-[1-[4-(pentafluoro-λ6-sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-2,3,4a,5,7,7a-hexahydrofuro[3,4-b][1,4]oxazine-4-carboxylic acid; -(rac)-[4-[2-(1,1-Dioxo-1,4-thiazinan-2-yl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ 6 -sulfanyl)phenyl]methanone; and -(rac)-7-[6-Fluoro-7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-2-oxa-5-azaspiro[3.5]nonane-5-carboxylic acid, and pharmaceutically acceptable salts thereof, selected from the group consisting of.

[0191] In embodiments, the compound is selected from the compounds prepared in Examples 1 to 461 (i.e., selected from the group consisting of Compounds 1 to 461) and pharmaceutically acceptable salts thereof. In other embodiments, the compound is selected from the synthetic methods described in any one of Examples 1 to 461 (i.e., the methods for synthesizing Compounds 1 to 461), and pharmaceutically acceptable salts thereof. In embodiments, the compound is selected from the compounds prepared in Examples 1 to 68 (i.e., selected from the group consisting of Compounds 1 to 68) and pharmaceutically acceptable salts thereof. In other embodiments, the compound is selected from the compounds that can be obtained by the synthetic method described in any one of Examples 1 to 68 (i.e., the methods for synthesizing Compounds 1 to 68) and pharmaceutically acceptable salts thereof.

[0192] In an embodiment, the compound is selected from the compounds of Examples 70, 75, 97, 98, 101, 121, 131, 133, 150, 151, 156, 170, 173, 174, 178, 184, 185, 188, 189, 197, 198, 199, 204, 222, 257, 297, 302, 305, 308, 311, 314, 316, 318, 319, 328, 331, 334, 335, 343, 344, 346, 349, 350, 356, 357, 364, 365, 366, 372, 379, 381, 382, 385, 392, 398, 399, 403, 404, 405, 409, 416, 418, 420, 423, 426, 427, 428, 429, 432, 433, 435, 436, 437, 443, 444, 447, 451, 453, 458, 459, and 460. In an embodiment, the compound is selected from the compounds of Examples 97, 98, 121, 133, 150, 156, 173, 178, 199, 204, 257, 349, 350, 356, 364, 365, 366, 372, 381, 382, 392, 398, 405, 426, 427, 428, 432, 436, 437, 443, 447, 451, and 460. In an embodiment, the compound is selected from the compounds of Examples 70, 75, 101, 131, 151, 170, 174, 184, 185, 188, 189, 197, 198, 222, 297, 302, 305, 308, 311, 314, 316, 318, 319, 328, 331, 334, 335, 343, 344, 346, 357, 379, 385, 399, 403, 404, 409, 416, 418, 420, 423, 429, 433, 435, 444, 453, 458, and 459.

[0193] In an embodiment, the compounds of the present disclosure are characterized by their inhibitory activity against ERK5, which is measured, for example, according to a cell-based assay or a cell-free assay as described in the following examples. In an embodiment, the compound has an IC against ERK5 of less than about 5 μM (when measured, for example, according to the cell-free assay described below). 50has a value. In embodiments, the compound has an IC of less than about 2 μM, such as less than about 1 μM, 0.5 μM, 0.2 μM, 100 nM or 50 nM, against ERK5 (e.g., as measured according to the cell-free assay described below). 50 has a value.

[0194] In an embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 59, 60, 61, 62, 63, 64, 65, 66, 67, and 68. In an embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 53, 54, 55, 56, 57, 60, 61, 62, 63, 64, 65, 66, 67, and 68. In another embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 42, 43, 44, 45, 46, 47, 50, 51, 53, 54, 56, 57, 61, 62, 63, 65, 67, and 68. In another embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 17, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 34, 36, 37, 39, 42, 43, 44, 46, 47, 50, 51, 53, 56, 57, 61, 62, 63, 65, 67, and 68. In another embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 22, 23, 24, 25, 26, 27, 28, 29, 34, 36, 37, 43, 44, 47, 50, 51, 57, 63, 65, 67, and 68. In another embodiment, the compound is selected from Compounds 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 22, 29, 37, 44, 51, 57, 63 and 65.In other embodiments, the compound is selected from compounds 3, 4, 5, 9, 12, 13, 22, 29, 37, 44, and 65.

[0195] In the embodiment, the compounds are those of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 80, 81, 82, 83, 84, 86, 88, 90, 91, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 108, 112, 113, 114, 116, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 136, 137, 138, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 154, 155, 156, 157, 158, 159, 160, 161, 163, 164, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291Selected from the compounds of 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 385, 387, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 446, 447, 448, 449, 450, 451, 452, 453, 454, 455, 456, 457, 458, 459, 460, and 461. In an embodiment, the compound is Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 53, 54, 55, 56, 57, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 81, 82, 83, 90, 91, 93, 94, 95, 96, 97, 98, 100, 101, 102, 103, 104, 108, 119, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 136, 137, 138, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 154, 155, 156, 157, 158, 159, 160, 161, 163, 164, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 188, 189, 191, 192, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 231, 232, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312Selected from the compounds of 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 342, 343, 344, 345, 346, 347, 349, 350, 351, 353, 354, 355, 356, 357, 358, 361, 364, 365, 366, 367, 368, 369, 370, 371, 372, 374, 375, 376, 377, 378, 379, 381, 382, 383, 384, 385, 386, 387, 388, 390, 391, 392, 393, 395, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 431, 432, 433, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 446, 447, 448, 449, 451, 453, 454, 456, 457, 458, 459, 460, and 461. In other embodiments, the compound is Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 42, 43, 44, 45, 46, 47, 50, 51, 53, 54, 56, 57, 61, 62, 63, 65, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 81, 82, 90, 91, 93, 94, 95, 96, 97, 98, 100, 101, 102, 103, 108, 119, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 137, 138, 140, 142, 143, 144, 145, 146, 148, 149, 150, 151, 152, 154, 155, 156, 157, 159, 160, 161, 163, 164, 166, 167, 168, 169, 170, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 188, 189, 191, 192, 194, 195, 196, 197, 198, 199, 200, 202, 203, 204, 205, 208, 209, 210, 212, 213, 215, 216, 219, 220, 222, 224, 225, 226, 227, 228, 229, 231, 234, 235, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 326, 327, 328, 329, 331, 332, 334, 335, 336, 338, 339, 340, 343, 344, 345, 346, 349, 350It is selected from the compounds of 351, 353, 354, 355, 356, 357, 364, 366, 368, 370, 371, 372, 374, 375, 376, 377, 381, 382, 383, 384, 385, 387, 390, 392, 397, 398, 399, 400, 401, 403, 404, 405, 406, 408, 414, 416, 418, 420, 422, 423, 424, 426, 427, 428, 429, 431, 435, 437, 440, 441, 442, 443, 444, 446, 447, 448, 449, 451, 457, 458, 459, 460, and 461. In other embodiments, the compound is Example 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 17, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 34, 36, 37, 39, 42, 43, 44, 46, 47, 50, 51, 53, 56, 57, 61, 62, 63, 65, 67, 68, 69, 70, 72, 73, 74, 75, 76, 81, 82, 93, 94, 95, 96, 97, 98, 100, 101, 102, 103, 119, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 140, 143, 144, 145, 146, 148, 149, 150, 151, 152, 154, 155, 156, 157, 159, 160, 161, 164, 166, 167, 168, 169, 170, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 188, 189, 191, 194, 195, 196, 197, 198, 199, 200, 202, 203, 204, 205, 208, 210, 213, 216, 219, 220, 222, 224, 225, 227, 229, 231, 234, 235, 237, 238, 239, 241, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 256, 257, 258, 260, 261, 262, 264, 265, 266, 267, 268, 269, 270, 271, 272, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 294, 295, 296,Selected from the compounds of 297, 298, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 311, 312, 313, 314, 315, 316, 318, 319, 320, 322, 323, 324, 326, 327, 328, 329, 331, 332, 334, 335, 338, 340, 343, 344, 345, 346, 349, 350, 351, 354, 356, 357, 364, 370, 372, 374, 375, 377, 381, 382, 383, 384, 385, 387, 390, 392, 397, 398, 405, 406, 408, 418, 420, 422, 423, 424, 426, 427, 428, 429, 435, 440, 441, 443, 444, 446, 447, 448, 449, 451, 457, 458, 459, 460, and 461. In other embodiments, the compound is Example 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 22, 23, 24, 25, 26, 27, 28, 29, 34, 36, 37, 43, 44, 47, 50, 51, 57, 63, 65, 67, 68, 70, 72, 73, 74, 75, 76, 93, 94, 96, 97, 98, 100, 101, 102, 103, 119, 121, 123, 124, 125, 126, 127, 128, 130, 131, 132, 133, 140, 144, 145, 146, 148, 149, 150, 151, 152, 154, 155, 156, 159, 160, 161, 166, 167, 169, 170, 173, 174, 175, 178, 179, 181, 182, 183, 184, 185, 188, 189, 191, 195, 196, 197, 198, 199, 200, 202, 204, 205, 208, 219, 220, 222, 227, 231, 237, 238, 239, 244, 245, 247, 248, 249, 251, 252, 253, 256, 257, 258, 261, 262, 264, 265, 266, 267, 268, 269, 270, 271, 274, 275, 276, 277, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 292, 294, 296, 297, 298, 302, 303, 305, 306, 307, 308, 309, 311, 312, 313, 314, 316, 318, 319, 320, 326, 327,It is selected from the compounds of 328, 329, 331, 334, 335, 343, 344, 345, 346, 349, 350, 357, 364, 385, 390, 392, 398, 405, 422, 423, 424, 426, 427, 428, 429, 435, 440, 443, 444, 447, 448, 451, 458, and 460. In other embodiments, the compound is Example 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 22, 29, 37, 44, 51, 57, 63, 65, 70, 72, 73, 74, 75, 94, 96, 97, 98, 100, 101, 121, 123, 125, 127, 128, 131, 133, 140, 146, 148, 149, 150, 151, 152, 154, 155, 156, 159, 169, 170, 173, 174, 175, 178, 181, 184, 185, 188, 189, 191, 195, 197, 198, 200, 202, 204, 208, 219, 220, 222, 227, 231, 237, 238, 239, 244, 247, 248, 249, 251, 252, 253, 256, 258, 262, 264, 265, 266, 268, 269, 270, 271, 277, 280, 281, 282, 283, 284, 285, 287, 288, 289, 297, 302, 305, 307, 308, 311, 314, 316, 318, 319, 320, 328, 329, 331, 334, 335, 343, 346, 349, 350, 385, 392, 398, 405, 426, 428, 429, 435, 443, 447, 451, and 460. In other embodiments, the compound is Example 3, 4, 5, 9, 12, 13, 22, 29, 37, 44, 65, 72, 97, 101, 123, 127, 128, 133, 140, 146, 149, 150, 151, 152, 154, 156, 169, 170, 173, 174, 175, 178, 184, 185, 188, 189, 191, 197, 202, 204, 208, 219, 222, 237, 249, 251, 253, 256, 262, 268, 270, 271, 281, 282, 283, 284, 285, 287, 288, 289, 307, 318, 343, 428, 435, and 460.

[0196] In an embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, and 68. In an embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 54, 55, 56, 57, 60, 61, 62, 63, 64, 65, 66, 67, and 68. In another embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 50, 51, 54, 56, 57, 60, 61, 62, 63, 64, 65, 66, 67, and 68. In another embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 42, 43, 44, 45, 46, 47, 50, 51, 56, 57, 60, 61, 63, 65, 67, and 68. In another embodiment, the compound is selected from the compounds of Examples 1, 2, 3, 4, 5, 7, 8, 9, 11, 12, 13, 19, 20, 22, 24, 25, 26, 27, 28, 29, 34, 36, 37, 42, 43, 44, 46, 47, 50, 51, 57, 65, 67, and 68. In an embodiment, the compound is selected from the compounds of Examples 1, 3, 4, 5, 7, 8, 9, 11, 12, 13, 22, 26, 27, 28, 29, 34, 37, 44, 57, and 65.In other embodiments, the compound is selected from the compounds of Examples 3, 4, 5, 9, 11, 12, 22, 29, and 37.

[0197] In the embodiment, the compound is described in Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273It is selected from the compounds of 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 341, 342, 343, 344, 345, 346, 347, 348, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 359, 360, 361, 362, 363, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 378, 379, 380, 381, 382, 400, 432, and 436. In an embodiment, the compound is Example 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 54, 55, 56, 57, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 81, 82, 83, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 108, 114, 119, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180,181、182、183、184、185、186、187、188、189、190、191、192、193、194、195、196、197、198、199、200、201、202、203、204、205、206、207、208、210、211、212、213、214、215、216、217、218、219、220、221、222、223、224、225、226、227、228、229、231、232、233、234、235、236、237、238、239、240、241、242、243、244、245、246、247、248、249、250、251、252、253、254、255、256、257、258、259、260、261、262、265、266、267、268、269、270、271、272、273、274、275、276、277、278、279、280、281、282、283、284、285、286、287、288、289、290、291、292、293、294、295、296、297、298、299、300、301、302、303、304、305、306、307、308、309、310、311、312、313、314、315、316、317、318、319、320、321、322、323、324、325、326、327、328、329、330、331、332、333、334、335、336、337、338、339、340、341、342、343、344、345、346、347、348、349、350、351、352、353、354、355、356、357、358、359、360、361、362、363、364、365、366、367、368、369、370、371、372、373、374、375、376、377、378、379、380、381、382、384、385、386、387、388、389、390、391、392、393、394、395、396、397、398、399、400、401、402、403、404、405、406、407、408、409、410、411、412、413、414、415、416、417、418、419、420、421、422、423、424、425、426、427、428、429、430、432、433、434、435、436、It is selected from the compounds of 437, 438, 439, 440, 441, 442, 443, 444, 447, 451, 452, 453, 454, 456, 457, 458, 459, and 460. In other embodiments, the compound is Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 17, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 50, 51, 54, 56, 57, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 81, 82, 90, 91, 94, 95, 96, 97, 98, 100, 101, 102, 103, 119, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 136, 137, 138, 140, 142, 143, 144, 145, 146, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 166, 167, 168, 169, 170, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 208, 210, 211, 212, 213, 214, 215, 216, 217, 219, 220, 221, 222, 224, 225, 227, 228, 229, 231, 232, 233, 234, 235, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 256, 257, 258, 259, 260, 261, 262, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 326, 327, 328, 329It is selected from the compounds of 330, 331, 332, 333, 334, 335, 336, 337, 338, 339, 340, 342, 343, 344, 345, 346, 347, 349, 350, 351, 353, 354, 355, 356, 357, 358, 359, 361, 364, 365, 366, 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 379, 380, 381, 382, 384, 385, 386, 388, 389, 390, 391, 392, 393, 394, 395, 396, 397, 398, 399, 400, 401, 402, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 447, 451, 453, 454, 456, 457, 458, 459, and 460., In other embodiments, the compound is as described in Examples 1, 2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 13, 15, 16, 17, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 42, 43, 44, 45, 46, 47, 50, 51, 56, 57, 60, 61, 63, 65, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 81, 82, 90, 91, 94, 95, 96, 97, 98, 100, 101, 102, 103, 119, 121, 122, 123, 125, 126, 127, 128, 129, 130, 131, 132, 133, 136, 137, 138, 140, 142, 143, 144, 145, 146, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 159, 160, 161, 162, 164, 166, 167, 168, 169, 170, 173, 174, 175, 176, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 191, 194, 195, 196, 197, 198, 199, 200, 202, 203, 204, 205, 208, 210, 212, 213, 215, 216, 219, 222, 225, 227, 228, 231, 234, 235, 237, 238, 239, 240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 256, 257, 258, 259, 260, 261, 262, 265, 266, 268, 269, 270, 271, 272, 273, 274, 275, 277, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 300, 301, 302, 304, 305, 306, 307, 308, 309, 310, 311, 312, 313, 314, 315, 316, 317, 318, 319, 320, 321, 322, 323, 324, 327, 328, 329, 330, 331, 332, 333, 334, 335, 336, 338, 339, 340, 342, 343, 344, 345, 346, 349, 350, 351, 353, 354, 355, 356, 357, 358, 364, 365, 366Selected from the compounds of 367, 368, 369, 370, 371, 372, 373, 374, 375, 376, 377, 379, 380, 381, 382, 384, 385, 386, 388, 389, 390, 391, 392, 393, 394, 395, 397, 398, 399, 400, 401, 403, 404, 405, 406, 407, 408, 409, 410, 411, 412, 413, 414, 415, 416, 417, 418, 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 447, 451, 453, 454, 457, 458, 459, and 460. In other embodiments, the compound is Example 1, 2, 3, 4, 5, 7, 8, 9, 11, 12, 13, 15, 17, 19, 20, 22, 24, 25, 26, 27, 28, 29, 34, 36, 37, 42, 43, 44, 46, 47, 50, 51, 57, 65, 67, 68, 69, 70, 72, 75, 76, 77, 94, 96, 97, 98, 100, 101, 102, 103, 119, 121, 122, 125, 126, 127, 128, 130, 131, 132, 133, 140, 143, 144, 145, 146, 148, 149, 150, 153, 154, 155, 156, 159, 160, 161, 166, 167, 169, 170, 173, 174, 175, 178, 179, 181, 184, 185, 186, 187, 188, 189, 191, 195, 196, 197, 198, 199, 200, 202, 204, 208, 212, 216, 219, 222, 228, 231, 234, 237, 238, 239, 241, 242, 244, 245, 248, 249, 251, 252, 253, 256, 257, 258, 262, 265, 268, 269, 270, 271, 281, 282, 283, 284, 285, 287, 288, 289, 290, 291, 292, 294, 296, 297, 298, 302, 304, 305, 306, 308, 309, 311, 312, 313, 316, 318, 320, 323, 327, 328, 331, 332, 333, 334, 335, 336, 340, 343, 344, 349, 350, 351, 353, 354, 355, 356, 357,It is selected from the compounds of 364, 365, 366, 367, 370, 371, 372, 374, 375, 376, 377, 379, 381, 382, 384, 385, 386, 390, 391, 392, 397, 398, 399, 400, 401, 403, 404, 405, 409, 414, 415, 416, 417, 418, 419, 420, 422, 423, 425, 426, 427, 428, 429, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 447, 451, 453, 454, 457, 458, 459, and 460. In an embodiment, the compound is the compound of Example 1, 3, 4, 5, 7, 8, 9, 11, 12, 13, 15, 17, 22, 26, 27, 28, 29, 34, 37, 44, 57, 65, 70, 72, 75, 76, 96, 97, 98, 101, 102, 121, 122, 125, 126, 127, 128, 131, 132, 133, 140, 144, 146, 149, 150, 154, 155, 156, 166, 167, 170, 173, 174, 178, 184, 185, 186, 187, 189, 195, 197, 198, 199, 200, 204, 212, 219, 222, 231, 237, 238, 244, 245, 248, 249, 251, 253, 256, 262, 268, 270, 271, 282, 283, 284, 285, 289, 290, 294, 297, 302, 305, 308, 311, 344, 349, 350, 351, 356, 357, 364, 365, 366, 367, 370, 371, 372, 375, 377, 381, 382, 384, 385, 398, 399, 403, 404, 405, 409, 416, 417, 418, 420, 422, 423, 426, 427, 428, 429, 432, 433, 435, 436, 440, 441, 443, 444, 447, 451, 453, 458, 459, and 460. In other embodiments, the compound is the compound of Example 3, 4, 5, 9, 11, 12, 15, 17, 22, 29, 37, 75, 97, 101, 121, 125, 127, 128, 131, 133, 146, 150, 154, 156, 166, 170, 173, 174, 178, 186, 187, 189, 197, 198, 199, 200, 204, 222, 237, 251, 253, 256,It is selected from the compounds of 270, 283, 284, 305, 350, 356, 357, 365, 366, 372, 381, 382, 385, 398, 405, 418, 426, 427, 428, 429, 432, 435, 436, 443, 447, 451, and 460.

[0198] Pharmaceutical composition The present disclosure provides a pharmaceutical composition comprising a compound described herein (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) and at least one pharmaceutically acceptable excipient or carrier.

[0199] In an embodiment, the pharmaceutical composition comprises a compound of formula (I) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (I-A) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (I-B) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (I-C) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (I-D) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (II) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (III) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (IV) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (V) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (VI) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (VI-A) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (VII) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (VII-A) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (VIII) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (VIII-A) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (IX) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (IX-A) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (X) or a pharmaceutically acceptable salt thereof. In an embodiment, the pharmaceutical composition comprises a compound of formula (X-A) or a pharmaceutically acceptable salt thereof.

[0200] The pharmaceutical compositions of the present disclosure can be formulated for administration in solid or liquid form, for example, using conventional carriers or excipients. The compositions can be adapted for oral administration (e.g., as solutions, suspensions, tablets, or capsules), parenteral administration (e.g., as solutions, dispersions, suspensions or emulsions, or as dry powders for reconstitution), or topical application (e.g., as creams, ointments, patches or sprays to be applied to the skin), for example, using techniques known in the art.

[0201] Medical use The compounds of the present disclosure act as inhibitors of ERK5 and confer utility in the treatment of ERK5-related disorders and conditions. In particular, the compounds of the present disclosure are useful in the treatment of cancer.

[0202] In view of this aspect, the present disclosure provides a method of treatment comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof). In a related aspect, the present disclosure provides the use of a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) in the manufacture of a medicament. In a further related aspect, the present disclosure provides a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) for use in therapy.

[0203] The compounds of the present disclosure are useful for treating or preventing a disease or adverse condition in which ERK5 or a variant or mutant thereof plays a role; a disease or disorder associated with an increase in MAPK7 (i.e., the ERK5 gene) expression and / or an increase in ERK5 activity; and a disease or disorder in which inhibition or antagonism of ERK5 activity is beneficial.

[0204] In one aspect, the present disclosure provides a method of treating or preventing a disease or disorder mediated by ERK5, or a disease or disorder in which ERK5 is involved, in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof). In a related aspect, the present disclosure provides the use of a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) in the manufacture of a medicament for treating or preventing a disease or disorder mediated by ERK5, or a disease or disorder in which ERK5 is involved. In a further related aspect, the present disclosure provides a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) for treating or preventing a disease or disorder mediated by ERK5, or a disease or disorder in which ERK5 is involved.

[0205] In another aspect, the present disclosure provides a method of treating or preventing a disease or disorder associated with ERK5 (e.g., cancer) in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof). In a related aspect, the present disclosure provides the use of a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) in the manufacture of a medicament for treating or preventing a disease or disorder associated with ERK5 (e.g., cancer). In a further related aspect, the present disclosure provides a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) for treating or preventing a disease or disorder associated with ERK5 (e.g., cancer).

[0206] In another aspect, the present disclosure provides a method of treating or preventing cancer in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof). In a related aspect, the present disclosure provides the use of a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) in the manufacture of a medicament for treating or preventing cancer. In a further related aspect, the present disclosure provides a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) for treating or preventing cancer.

[0207] In embodiments, the compound reduces angiogenesis, reduces or prevents metastasis, reduces inflammation, blocks tumorigenesis (e.g., partially or completely), reduces avoidance of growth inhibition, reduces or inhibits the growth of cancerous or precancerous cells, suppresses the proliferation of cancerous or precancerous cells, and / or reduces the survival of cancerous or precancerous cells.

[0208] In embodiments, the cancer is characterized by an increase in MAPK7 (i.e., ERK5 gene) expression and / or an increase in ERK5 activity. In embodiments, the cancer has elevated ERK5 activity. In embodiments, the cancer overexpresses ERK5. In embodiments, the cancer is characterized by MAPK7 genomic amplification and / or constitutively active ERK5 signaling. In embodiments, the cancer has genomic amplified ERK5. In embodiments, the cancer has constitutively active ERK5 signaling.

[0209] In embodiments, the cancer is a solid tumor (e.g., melanoma, carcinoma or blastoma). In other embodiments, the cancer is leukemia (e.g., chronic lymphocytic leukemia, CLL; acute myeloid leukemia, AML; or chronic myeloid leukemia, CML).

[0210] In embodiments, the cancer is a primary tumor. In other embodiments, the cancer is a secondary tumor (e.g., a metastatic tumor).

[0211] In embodiments, the cancer is selected from breast cancer (e.g., ductal breast cancer or lobular breast cancer), liver cancer, kidney cancer (e.g., hepatocellular carcinoma), prostate cancer, colorectal cancer (CRC), lung cancer (e.g., non-small cell lung cancer, NSCLC; lung adenocarcinoma; or lung squamous cell carcinoma), pancreatic cancer (e.g., adenocarcinoma), ovarian cancer, brain cancer (e.g., glioblastoma), cervical cancer (e.g., adenocarcinoma), gastric cancer, skin cancer, cholangiocarcinoma (e.g., cholangiocellular carcinoma), nervous system cancer (e.g., neuroblastoma), and melanoma.

[0212] In embodiments, the cancer is selected from leukemia (e.g., acute leukemia, acute lymphoblastic leukemia, acute myeloblastic leukemia, acute myeloblastic leukemia, acute promyelocytic leukemia, acute monocytic leukemia, acute monocytic leukemia, acute erythroleukemia, chronic leukemia, chronic myelogenous leukemia, or chronic lymphocytic leukemia), polycythemia vera, lymphoma (e.g., Hodgkin's disease or non-Hodgkin's disease), Waldenström macroglobulinemia, and multiple myeloma.

[0213] In embodiments, the cancer is selected from leukemia (e.g., chronic myeloid leukemia), breast cancer, multiple myeloma, colon cancer, renal cell carcinoma, mesothelioma, adenocarcinoma, neuroblastoma, and hepatocellular carcinoma.

[0214] In another aspect, the present disclosure provides a method of inhibiting ERK5 activity, the method comprising contacting ERK5 (e.g., a cell comprising ERK5) with a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof). In embodiments, the method is an in vitro or ex vivo method. In other embodiments, the method is an in vivo method. In related aspects, the present disclosure provides an in vitro method of inhibiting ERK5 activity in a cell, the method comprising contacting the cell with a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof).

[0215] The compounds of the present disclosure (e.g., compounds of formula (I)) and pharmaceutically acceptable salts thereof may be administered as a pharmaceutical composition optionally comprising one or more pharmaceutically acceptable excipients.

[0216] The methods and treatments of various aspects of the present disclosure can be achieved, as described herein, by administering to a subject an effective amount of a compound of the present disclosure (e.g., a compound of formula (I) or a pharmaceutically acceptable salt thereof) in the form of a pharmaceutical composition which may optionally include one or more pharmaceutically acceptable excipients.

[0217] The compounds of the present disclosure can be used alone (e.g., as monotherapy) or in combination with one or more cancer treatments.

[0218] Although generally described herein, the following non-limiting examples are provided to further illustrate the present disclosure.

Example

[0219] General synthetic scheme Scheme 1A, which is the following scheme, shows an exemplary method for preparing a compound according to the present disclosure and examples.

Chemical formula

[0220] Scheme 1A (R 1 , L 1 , R 2 , L 2 , R 3 , R 4 , R 5According to (and n can be, for example, as described above), compound 1C can be obtained in step 1 by Suzuki coupling between compound 1A (where X can be I, Br, or Cl) and compound 1B using a catalyst such as [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complexed with DCM, for example, by heating to reflux the solvent in a mixture of dioxane and water and in the presence of a base. Compound 1C can be reduced to compound 1D in step 2, for example, by hydrogenation using a catalyst such as Pd / C under a hydrogen pressure of about 5 bar at 40 °C (H2). Subsequently, compound 1D can be converted to compound 1F in step 3 by adding it, for example, to a premixed solution in acetonitrile of a carboxylic acid (compound 1E) and CDI and then heating to reflux. Alternatively, compound 1D can be coupled with compound 1E using EDC in a solvent such as DMF in the presence of a base known to those skilled in the art, such as pyridine, and then heating with AcOH up to 80 °C to obtain compound 1F. Compound 1F can be converted to compound 1G in step 4 by treatment with an acid such as neat TFA or an HCl solution in dioxane in a solvent such as MeOH. In step 5, compound 1I where E is -C(O)- can be obtained by peptide coupling between compound 1G and compound 1H using conditions known to those skilled in the art, such as EDC and DIEA in a solvent such as DMF in the presence of 4-DMAP or HATU. Compound 1I where E is -S(O)2- can be obtained by treating compound 1G with compound 1H' using conditions known to those skilled in the art, for example, by treatment with a base such as triethylamine in a solvent such as DCM.

[0221] Another method for converting compound 1D to compound 1I is shown in Scheme 1B below.

Chemical formula

[0222] Scheme 1B (wherein R 1 , L 1 , R2 , L 2 , R 3 , R 4 , R 5 According to the method of the present invention, compound 1J can be obtained in step 1 either by treating compound 1D with an acid such as TFA in a solvent such as DCM, followed by peptide coupling with compound 1H in the presence of a base such as DIEA, in a solvent such as DMF, using conditions known to those skilled in the art such as HATU, or by reaction with compound 1H' and a base such as triethylamine, for example, in a solvent such as DCM. Compound 1J can then be converted to compound 1I (wherein E is -C(O)- or -S(O)2-) in step 2 by coupling with compound 1E using conditions such as CDI in acetonitrile, followed by heating to reflux.

[0223] Compounds where E is -O- can be synthesized similarly to the methods described above, for example using a modified version of Scheme 1A. For example, an analog of compound 1G (compound 1G' below) having a carbon atom in place of the piperidine nitrogen and a protected hydroxyl group can be deprotected and converted to R by alkylation (e.g., using the Williamson reaction to give alkyl ethers) or Mitsunobu reaction (e.g., to give aryl or heteroaryl ethers). 2 It can be coupled to a containing group, as shown in Scheme 1C below. [ka]

[0224] Experimental techniques At 400MHz and 500MHz 1 H NMR spectra were performed on Bruker Avance DRX-400 and Bruker Avance DPX-500 spectrometers, respectively, and chemical shifts (δ (ppm)) in the solvent dimethylsulfoxide-d6 (DMSO-d6) were referenced at 2.5 ppm at the quoted temperatures. Coupling constants (J) are given in Hertz.

[0225] For the intermediates in the following synthesis procedures, liquid chromatography / mass spectrometry (LC / MS) was obtained using a UPLC Acquity Waters instrument, a Sedere light scattering detector, and an SQD Waters mass spectrometer, with UV detection DAD210 <l<400 nm and a column Acquity UPLC CSH C18 1.7 μm, dimensions 2.1×30 mm, and mobile phases H2O + 0.0% HCO2H / CH3CN + 0.0% HCO2H.

[0226] For the compounds prepared as the final products of the following synthesis methods (i.e., for the compounds of Examples 1 to 461), LC / MS was obtained as specified by Method 1, Method 2, or Method 3.

[0227] Method 1 Liquid chromatography / mass spectrometry (LC / MS) was obtained using a Waters ACQUITY UPLC instrument equipped with a Waters SQD2 under the following conditions, using positive and negative electrospray ionization (ES+ / -).

[0228] [Table 1]

[0229] Method 2 Liquid chromatography / mass spectrometry (LC / MS) was obtained using a Waters ACQUITY UPLC instrument equipped with a Waters SQD2 under the following conditions, using positive and negative electrospray ionization (ES+ / -).

[0230] [Table 2]

[0231] Method 3 Liquid chromatography / mass spectrometry (LC / MS) was obtained on a Waters ACQUITY UPLC instrument equipped with a Waters SQD2 using positive and negative electrospray ionization (ES+ / -) under the following conditions.

[0232] [Table 3]

[0233] All synthetic reactions were carried out under an inert atmosphere unless otherwise specified. In the following examples, when the source of the starting product is not specified, the product should be understood to be a known compound (e.g., a compound commercially available from a supplier such as Sigma-Aldrich).

[0234] Separation of isomers of the compound (e.g., chiral separation) was carried out by one of the following methods as specified in the following synthetic methods.

[0235] Method CS1 Separation of the corresponding mixture (e.g., 0.19 mmol thereof) was carried out using a chiralpak IC column (20 μm, 100×230 mm) eluting with (n-heptane 30% EtOH 70%) + 0.1% TEA (flow rate 400 mL / min, UV detection at 265 nm).

[0236] Method CS2 Separation of the corresponding mixture (e.g., 0.30 mmol thereof) was carried out using a chiralpak AD column (20 μm, 350×76.5 mm) eluting with (n-heptane 80% EtOH 20%) + 0.1% TEA (flow rate 400 mL / min, UV detection at 265 nm).

[0237] Method CS3 Separation of the corresponding mixture (e.g., 0.08 mmol thereof) was carried out using an I Cellulose5 column (5 μm, 250×30 mm) eluting with (n-heptane 40% EtOH 60%) + 0.1% TEA (flow rate 1 mL / min, UV detection at 265 nm).

[0238] Method CS4 The separation of the corresponding mixture (e.g., 0.1 mmol thereof) was carried out using a Chiralcel OD-H column (5 μm, 250×30 mm) eluted with (n-heptane 85% EtOH 15%) + 0.1% TEA (flow rate 40 mL / min, UV detection at 265 nm).

[0239] Method CS5 The separation of the corresponding mixture (e.g., 0.35 mmol thereof) was carried out using a Phenomenex Cellulose-4 column (20 μm, 350×76.5 mm) eluted with (n-heptane 50% TEA 0.1%, EtOH 50% TEA 0.1%) (flow rate 24 L / h, UV detection at 265 nm).

[0240] Method CS6 The separation of the corresponding mixture (e.g., 0.08 mmol thereof) was carried out using an i-amylose-3 column (5 μm, 250×30 mm) eluted with n-heptane 80%, EtOH 20%) + TEA 0.1% (flow rate 40 mL / min, UV detection at 265 nm).

[0241] Method CS7 The separation of the corresponding mixture (e.g., 0.26 mmol thereof) was carried out using a Chiralpak AS column (10 μm, 250×4.6 mm) eluted with (MeOH 40%, CO2 60%) + TEA 0.1% (flow rate 120 mL / min, UV detection at 254 nm).

[0242] Method CS8 The separation of the corresponding mixture (e.g., 0.09 mmol thereof) was carried out using a Whelk 01 SS column (10 μm, 250×4.6 mm) eluted with (n-heptane 80% TEA 0.1%, EtOH 20% TEA 0.1%) (flow rate 1 mL / min, UV detection at 265 nm).

[0243] Method CS9 The separation of the corresponding mixture (e.g., 0.18 mmol thereof) was carried out using a Chiralpak IJ column (5 μm, 250×30 mm) eluted with (MeOH 20%, CO₂ 80%) (flow rate 200 mL / min, UV detection at 265 nm).

[0244] Method CS10 The separation of the corresponding mixture (e.g., 0.11 mmol thereof) was carried out using a Cellulose 4 column (5 μm, 250×4.6 mm) eluted with (n-heptane 40% EtOH 60%) + 0.1% TEA (flow rate 1 mL / min, UV detection at 265 nm).

[0245] Method CS11 The separation of the corresponding mixture (e.g., 0.07 mmol thereof) was carried out using a Chiralpak OZ-H column (5 μm, 250×30 mm) eluted with (n-heptane 80% EtOH 20%) + 0.1% TEA (flow rate 40 mL / min, UV detection at 265 nm).

[0246] Method CS12 The separation of the corresponding mixture (e.g., 0.18 mmol thereof) was carried out using a Chiralpak AY column (20 μm, 230×100 mm) eluted with (n-heptane 80% EtOH 20%) + 0.1% TEA (flow rate 400 mL / min, UV detection at 265 nm).

[0247] Method CS13 The separation of the corresponding mixture (e.g., 0.28 mmol thereof) was carried out using a Chiralpak OZ column (20 μm, 250×4.6 mm) eluted with (n-heptane 20% EtOH 80%) + 0.1% TEA (flow rate 1 mL / min, UV detection at 265 nm).

[0248] Method CS14 The separation of the corresponding mixture (e.g., 0.075 mmol thereof) was carried out using a Chiralpak IG column (5 μm, 250×30 mm) eluted with (n - heptane 85%, ethanol 15%) + 0.1% TEA (flow rate 40 mL / min, UV detection at 265 nm).

[0249] Method CS15 The separation of the corresponding mixture (e.g., 0.10 mmol thereof) was carried out using a chiralpak AD column (20 μm, 50×300 mm) eluted with (CO2 (SFC) 85% MeOH 15%) + 0.1% TEA (flow rate 200 mL / min, UV detection at 265 nm).

[0250] Method CS16 The separation of the corresponding mixture (e.g., 0.16 mmol thereof) was carried out using an XSELECT CSH preparative C18 column (5 μm, 50×250 mm) eluted with (H2O + 0.1% HCOOH, MeCN, gradient) (flow rate 80 mL / min, UV detection at 265 nm).

[0251] Method CS17 The separation of the corresponding mixture (e.g., 0.25 mmol thereof) was carried out using a Chiracel OD - I column (20 μm, 76.5×350 mm) eluted with (n - heptane 70 / EtOH 30) + 0.1% TEA (flow rate 400 mL / min, UV detection at 280 nm).

[0252] Method CS18 The separation of the corresponding mixture (e.g., 0.18 mmol thereof) was carried out using a Chiralpak IH column (5 μm, 250×30 mm) eluted with (n - heptane 82%, ethanol 18%) + 0.1% TEA (flow rate 40 mL / min, UV detection at 265 nm).

[0253] Method CS19 The separation of the corresponding mixture (e.g., 0.36 mmol thereof) was carried out using a Phenomenex lux amylose-1 column (5 μm, 250×30 mm) eluted with (n-heptane 80%, EtOH 20%) + 0.1% TEA (flow rate 45 mL / min, UV detection at 265 nm).

[0254] Method CS20 The separation of the corresponding mixture (e.g., 0.18 mmol thereof) was carried out using a Chiralpak IF column (5 μm, 250×30 mm) eluted with (n-heptane 80%, ethanol 20%) + 0.1% TEA (flow rate 1 mL / min, UV detection at 265 nm).

[0255] Method CS21 The separation of the corresponding mixture was carried out using a Chiralpak AS-H column (5 μm, 20×250 mm) eluted with CO2 / 30% (MeOH + 0.1% TEA), flow rate 50 mL / min, UV detection at 254 nm, back pressure regulator 100 bar, T = 40°C.

[0256] Example 1 to 461 - Compound Table 1 below lists the compounds synthesized in the following synthesis examples.

[0257] [Table 4]

[0258] [Table 5]

[0259] [Table 6]

[0260] [Table 7]

[0261]

Table 8

[0262]

Table 9

[0263]

Table 10

[0264]

Table 11

[0265]

Table 12

[0266]

Table 13

[0267]

Table 14

[0268]

Table 15

[0269]

Table 16

[0270]

Table 17

[0271]

Table 18

[0272]

Table 19

[0273]

Table 20

[0274]

Table 21

[0275]

Table 22

[0276]

Table 23

[0277]

Table 24

[0278]

Table 25

[0279]

Table 26

[0280]

Table 27

[0281]

Table 28

[0282]

Table 29

[0283]

Table 30

[0284]

Table 31

[0285]

Table 32

[0286]

Table 33

[0287]

Table 34

[0288]

Table 35

[0289]

Table 36

[0290]

Table 37

[0291]

Table 38

[0292]

Table 39

[0293]

Table 40

[0294]

Table 41

[0295]

Table 42

[0296]

Table 43

[0297]

Table 44

[0298]

Table 45

[0299]

Table 46

[0300]

Table 47

[0301]

Table 48

[0302]

Table 49

[0303]

Table 50

[0304]

Table 51

[0305]

Table 52

[0306]

Table 53

[0307]

Table 54

[0308]

Table 55

[0309]

Table 56

[0310]

Table 57

[0311]

Table 58

[0312]

Table 59

[0313]

Table 60

[0314]

Table 61

[0315]

Table 62

[0316]

Table 63

[0317]

Table 64

[0318]

Table 65

[0319]

Table 66

[0320]

Table 67

[0321]

Table 68

[0322]

Table 69

[0323]

Table 70

[0324]

Table 71

[0325]

Table 72

[0326]

Table 73

[0327]

Table 74

[0328]

Table 75

[0329] Examples 1 and 2: [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, Isomers 1 and 2

Chemical formula

Chemical formula

[0330] Step 2: Tert-butyl 4-(2,3-diamino-4-pyridyl)piperidine-1-carboxylate

Chemical formula

[0331] Step 3: (Rac)-tert-butyl 4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperidine-1-carboxylate

Chemical formula

[0332] Step 4: (Rac)-7-(4-Piperidyl)-2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridine, dihydrochloride

Chemical Structure

[0333] Step 5: (Rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone [Chemical formula] (rac)-7-(4-Piperidyl)-2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridine dihydrochloride (130 mg, 0.36 mmol) in DMF (2.4 mL) was added with DIPEA (0.32 mL, 1.81 mmol) at room temperature under an argon atmosphere. After solubilization of the starting material, 2-amino-4-(trifluoromethoxy)benzoic acid (88 mg, 0.4 mmol) was added, followed by addition of HATU (165 mg, 0.43 mmol). The resulting mixture was then stirred at room temperature for 2 h. The reaction mixture was diluted with AcOEt (40 mL), transferred to a separatory funnel, washed with a saturated aqueous solution of NaHCO3 and then with water. The organic layer was then dried over sodium sulfate, filtered and concentrated in vacuo. The obtained residue (brown oil) was purified by flash chromatography (SiO2 12 g eluting with DCM 93 / MeOH 7 / NH4OH 0.7) to give 106 mg (59%) of (rac)-[2-amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone as a pale yellow solid. LC / MS (m / z, M+H): 490

[0334] Chiral separation of (rac)-[2-amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone (83 mg, 0.17 mmol) using a chiralpak AY column (20 μm, 100×230 mm) eluting with (n-heptane 80% EtOH 15% MeOH 5) + 0.1% TEA (flow rate 40 mL / min, UV detection at 280 nm) gave 37 mg (44%) of the first eluting isomer 1 (Example 1) and 40 mg (48%) of isomer 2 (Example 2) as white solids.

[0335] Isomer 1 (Example 1): LC / MS (m / z, M+H, method 2): calculated 490, found 490.3 11H NMR (400 MHz, DMSO-d6, 30 °C, 70 / 30 mixture of conformers) δ ppm 1.54 - 1.70 (m, 1H), 1.70 - 1.95 (m, 4H), 1.95 - 2.09 (m, 1H), 2.69 - 2.81 (m, 1H), 2.84 - 3.22 (m, 2H), 2.89 (br d, J = 7 Hz, 2H), 3.18 - 3.40 (m partially hidden, 1H), 3.39 - 3.53 (m, 2H), 3.66 (q, J = 8 Hz, 1H), 3.74 - 3.85 (m, 2H), 3.89 - 4.65 (m, 1H), 5.58 (br s, 2H), 6.49 (br d, J = 8 Hz, 1H), 6.66 (br d, J = 1 Hz, 1H), 7.05 (d, J = 5 Hz, 1H), 7.15 (br d, J = 8 Hz, 1H), 8.14 (br d, J = 5 Hz, 0.7H), 8.18 - 8.35 (m, 0.3H), 12.49 (br s, 0.3H), 12.80 (br s, 0.7H)

[0336] Isomer 2 (Example 2): LC / MS (m / z, M+H, Method 2): Calcd 490, Found 490.3; 1H NMR (400 MHz, DMSO-d6, 30 °C, 70 / 30 mixture of conformers) δ ppm 1.57 - 1.69 (m, 1H), 1.70 - 1.94 (m, 4H), 1.95 - 2.09 (m, 1H), 2.69 - 2.81 (m, 1H), 2.85 - 2.96 (m, 2H), 2.95 - 3.40 (m partially hidden, 3H), 3.39 - 3.52 (m, 2H), 3.58 - 3.71 (m, 1H), 3.73 - 3.87 (m, 2H), 5.58 (s, 1.4H), 5.61 (s, 0.6H), 6.49 (br d, J = 8 Hz, 1H), 6.66 (br s, 1H), 7.02 - 7.08 (m, 1H), 7.12 - 7.22 (m, 1H), 8.14 (d, J = 5 Hz, 0.7H), 8.23 (d, J = 5 Hz, 0.3H), 12.47 (s, 0.3H), 12.78 (br s, 0.7H)

[0337] Examples 3 and 4: [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, Isomers 1 and 2 [Chemical formula] Process 1: (Rac)-tert-butyl 4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carboxylate [Chemical formula] Process 1 of Examples 3 and 4 was prepared from acetonitrile (8.6 mL) containing tert-butyl 4-(2,3-diamino-4-pyridyl)piperidine-1-carboxylate (250 mg, 0.86 mmol) and tetrahydrofuran-3-carboxylic acid (99 mg, 0.85 mmol) according to the same procedure as in Process 3 of Examples 1 and 2 to obtain 144 mg (45%) of (rac)-tert-butyl 4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carboxylate as a light brown solid. LC / MS (m / z, M+H): 373

[0338] Process 2: (Rac)-7-(4-piperidyl)-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridine, dihydrochloride [Chemical formula] Process 2 of Examples 3 and 4 was prepared from (rac)-tert-butyl 4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carboxylate (141 mg, 0.38 mmol) according to the same procedure as in Process 4 of Examples 1 and 2 to obtain 130 mg (100%) of (rac)-7-(4-piperidyl)-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridine dihydrochloride as a light brown solid. LC / MS (m / z, M+H): 273

[0339] Step 3: (Rac)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone

Chem.

[0340] Chiral separation of (rac)-[2-amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone (93 mg, 0.19 mmol) using a chiralpak AY column (20 μm, 100×230 mm) eluting with (n-heptane 70% EtOH 25% MeOH 5%) + 0.1% TEA (flow rate 40 mL / min, UV detection at 265 nm) gave 42 mg (45%) of the first eluted isomer 1 (Example 3) and 48 mg (52%) of isomer 2 (Example 4) as white solids.

[0341] Isomer 1 (Example 3): LC / MS (m / z, M+H, method 2): calculated value 476, measured value 476.1; 11H NMR (400 MHz, DMSO-d6, 100 °C) δ ppm 1.82 - 1.99 (m, 4H), 2.34 (q, J = 7 Hz, 2H), 3.04 - 3.17 (m, 2H), 3.35 - 3.49 (m, 1H), 3.67 (quin, J = 8 Hz, 1H), 3.83 (q, J = 7 Hz, 1H), 3.89 - 4.01 (m, 2H), 4.07 - 4.12 (m, 1H), 4.16 (br d, J = 13 Hz, 2H), 5.34 (s, 2H), 6.48 (br dd, J = 8, 1 Hz, 1H), 6.68 (br d, J = 1 Hz, 1H), 7.01 (d, J = 5 Hz, 1H), 7.14 (d, J = 9 Hz, 1H), 8.15 (d, J = 5 Hz, 1H), 11.88 - 12.82 (m, 1H)

[0342] Isomer 2 (Example 4): LC / MS (m / z, M+H, Method 2): Calculated value 476, Measured value 476.1; 1 1H NMR (400 MHz, DMSO-d6, 100 °C) δ ppm 1.82 - 1.99 (m, 4H), 2.34 (q, J = 7 Hz, 2H), 3.04 - 3.17 (m, 2H), 3.35 - 3.49 (m, 1H), 3.67 (quin, J = 8 Hz, 1H), 3.83 (q, J = 7 Hz, 1H), 3.89 - 4.01 (m, 2H), 4.07 - 4.12 (m, 1H), 4.16 (br d, J = 13 Hz, 2H), 5.34 (s, 2H), 6.48 (br dd, J = 8, 1 Hz, 1H), 6.68 (br d, J = 1 Hz, 1H), 7.01 (d, J = 5 Hz, 1H), 7.14 (d, J = 9 Hz, 1H), 8.15 (d, J = 5 Hz, 1H), 11.88 - 12.82 (m, 1H)

[0343] Example 5: [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone

Chemical Structure

[0344] Step 2: [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydro-4H-pyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone [Chem.] Under an argon atmosphere, to a solution of tert-butyl 4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carboxylate (69 mg, 0.18 mmol) in DCM (1.7 mL) at room temperature was added TFA (0.23 mL, 2.87 mmol), and the reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was then concentrated to dryness in vacuo. The resulting residue was diluted with DMF (1.2 mL), and under an argon atmosphere, DIEA (0.37 mL, 2.14 mmol) was added portionwise, followed 5 minutes later by HATU (68 mg, 0.18 mmol). The resulting mixture was then stirred at room temperature for 3.5 hours. The reaction mixture was then diluted with water (15 mL) and 1N aqueous NaOH solution (15 mL), transferred to a separatory funnel, and extracted 3 times with AcOEt. The organic layers were combined, washed with saturated aqueous sodium chloride solution, dried over sodium sulfate, and concentrated in vacuo. The resulting residue was suspended in a minimum amount of DCM, solubilized by the addition of 3 drops of MeOH, and then pentane was added slowly until a white precipitate appeared. This was filtered, washed with pentane, and dried under vacuum to give 65 mg (74%) of [2-amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone as a pale yellow solid. LC / MS (m / z, M+H, method 2): calcd 490, found 490.2; 1 H NMR (400 MHz, DMSO-d6, 101°C) δ ppm 1.75 - 2.02 (m, 8H), 3.00 - 3.23 (m, 3H), 3.31 - 3.47 (m, 1H), 3.44 - 3.56 (m, 2H), 3.95 (dt, J = 11, 3 Hz, 2H), 4.17 (br d, J = 13 Hz, 2H), 5.33 (s, 2H), 6.48 (dd, J = 8, 1 Hz, 1H), 6.68 (d, J = 1 Hz, 1H), 7.00 (d, J = 5 Hz, 1H), 7.15 (d, J = 8 Hz, 1H), 8.14 (br d, J = 5 Hz, 1H), 12 - 12.6 (m, 1H)

[0345] Example 6: [4-[2-(4-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone

Chemical Structure

Chemical Structure

[0346] Step 2: Tert-butyl 4-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidine-1-carboxylate

Chem.

[0347] Step 3: [4-[2-(4-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone

Chem.

[0348] Example 7: (trans)-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone [Chemical formula] Step 1: (trans)-4-Acetoxycyclohexanecarboxylic acid [Chemical formula] Under an argon atmosphere, acetic anhydride (2.5 mL, 26 mmol) was added dropwise to a solution of (trans)-4-hydroxycyclohexanecarboxylic acid (500 mg, 3.29 mmol) in pyridine (5 mL) at 5 °C. After 10 minutes, the reaction mixture was warmed to room temperature. After 1 hour, the reaction mixture was poured into crushed ice and acidified to pH = 1 with HCl. The whole mixture was transferred to a separatory funnel and extracted twice with AcOEt. Then, the combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to give 613 mg (100%) of (trans)-4...

Claims

1. Formula (I): 【Chemical 1】 or a pharmaceutically acceptable salt thereof, wherein R １ is selected from -H, -(C １ ~C ６ )alkyl, -(C ３ ~C ７ )cycloalkyl, -(C ４ ~C ８ )cycloalkenyl, -(C ６ ~C １０ )aryl, 4- to 10-membered heterocycloalkyl, 5- to 8-membered heterocycloalkenyl, and 5- to 10-membered heteroaryl, and R １ is optionally substituted in one or more occurrences of R Ａ ; Each R Ａ is independently selected from halo, -OH, -NHR', -CN, oxo, -SO ２ CH ３ , -(C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl, -C(O)R'', -C(O)NHR', -NHC(O)R'', -(C ３ ~C ６ )cycloalkyl, 3- to 6-membered heterocycloalkyl, phenyl, and pyridyl, and each occurrence of -(C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl, and phenyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH ２ and -CN, and / or R Ａ two occurrences of which, together with the atoms to which they are attached, can form a (C ３ -C ６ ) cycloalkyl group or a 3- to 6-membered heterocycloalkyl group each R’ is independently selected from -H, methyl, and phenyl, Each R'' is independently selected from -OH, methyl, phenyl optionally substituted with -OCF ３ and tetrahydrofuranyl, L １ is selected from direct bond, -O-, -CH ２ -, and -CH=, R ２ is selected from -(C ３ ~C ６ ) cycloalkyl, 5- to 10-membered heterocycloalkyl, -(C ６ ~C １０ ) aryl, and 5- to 10-membered heteroaryl, and R ２ is optionally substituted in one or more occurrences of R Ｂ . Each R Ｂ is selected from halo, -OH, oxo, -NH ２ , -NHMe, -NO ２ , -CN, -SF ５ , -SiMe ３ , -B(OH) ２ , -(C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl, -(C ３ ~C ６ )cycloalkyl, -SO ２ CH ３ , -NHCOMe, phenyl, benzyl, 1-λ ６ -2-thiazolidine-1,1-dionyl and pyridyl, and each occurrence of -(C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl, -(C ３ ~C ６ )cycloalkyl, phenyl, and benzyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH ２ and -CF ３ , Furthermore, R ２ is -(C ３ ~C ６ ) cycloalkyl, R ２ is optionally substituted at one ring atom by a spirocyclic oxindolyl group, L ２ is selected from direct bond, -CH ２ -, -CH ２ CH ２ -, and -CH ２ O-, where L ２ , when present, is optionally substituted with -NH ２ or methyl, R ３ is selected from -H, halo, -OH, and methyl optionally substituted with -OH, R ４ is -H or -NH ２ and R ５ is -H or methyl, X is CH or N, Y is selected from CH, CF, and N (provided that when Y is N, X is also N), E is selected from -C(O)-, -S(O)-, and -O- (provided that when E is -O-, both X and Y are CH). ２ and, (wherein when E is -O-, both X and Y are CH), n is 0, 1, or 2, a compound of formula (I) or a pharmaceutically acceptable salt thereof.

2. wherein the compound is of formula (I-A) [Chemical Formula 2] is a compound or a pharmaceutically acceptable salt thereof, wherein R １ ,R ２ ,R ３ ,R ５ ,L １ ,X, Y, and n are as defined in claim 1, The compound according to claim 1.

3. wherein the compound is of formula (I-B) [Chemical Formula 3] is a compound or a pharmaceutically acceptable salt thereof, R １ R ２ R ３ R ５ L １ and n are as defined in any one of claims 1 or 2, a compound according to claim 1 or 2.

4. R １ is selected from -H, -(C １ ~C ６ )alkyl, -(C ３ ~C ７ )cycloalkyl, -(C ４ ~C ８ )cycloalkenyl, -(C ６ ~C １０ )aryl, 4- to 10-membered heterocycloalkyl, 5- to 8-membered heterocycloalkenyl, and 5- to 10-membered heteroaryl, and R １ is optionally substituted in one or more occurrences of R Ａ ​ Each R Ａ is independently selected from halo, -OH, -NHR', -CN, oxo, -SO ２ CH ３ , -(C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl, -C(O)R'', -C(O)NHR', -NHC(O)R'', -(C ３ ~C ６ )cycloalkyl, 3- to 6-membered heterocycloalkyl, phenyl, and pyridyl, and each occurrence of -(C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl, and phenyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH ２ and -CN, and / or R Ａ two occurrences of which, together with the atoms to which they are attached, may form a (C ３ -C ６ ) cycloalkyl group or a 3- to 6-membered heterocycloalkyl group each R’ is independently selected from -H, methyl, and phenyl, Each R'' is independently selected from methyl, phenyl optionally substituted with ３ -OCF ３ and tetrahydrofuranyl, R ２ is selected from -(C ３ ~C ６ ) cycloalkyl, 5- to 10-membered heterocycloalkyl, -(C ６ ~C １０ ) aryl, and 5- to 10-membered heteroaryl, and R ２ is optionally substituted in one or more occurrences of R Ｂ ​ Each R Ｂ is selected from halo, -OH, -NH ２ , -NO ２ , -CN, -SF ５ , -B(OH) ２ , -(C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl, -(C ３ ~C ６ )cycloalkyl, -SO ２ CH ３ , phenyl, benzyl, 1-λ ６ -2-thiazolidine-1,1-dionyl and pyridyl, and each occurrence of -(C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl, -(C ３ ~C ６ )cycloalkyl, phenyl and benzyl is optionally substituted by one or more groups independently selected from halo, -OH, -NH ２ and -CF ３ ; Furthermore, R ２ is -(C ３ ~C ６ ) cycloalkyl, R ２ is optionally substituted at one ring atom by a spirocyclic oxindolyl group, X and Y are each independently selected from CH and N (provided that when Y is N, X is also N), The compound according to any one of claims 1 to 3.

5. wherein the compound is of formula (I-C) or formula (I-D) 【Chemical Formula 4】 is a compound or a pharmaceutically acceptable salt thereof, R １ , R ２ 、R ３ and L １ is as defined in any one of claims 1 to 4, and the compound according to any one of claims 1 to 4.

6. R ２ is selected from -(C ３ -C ６ ) cycloalkyl, 5- to 6-membered heterocycloalkyl, 9- to 10-membered heterocycloalkyl, -(C ６ -C １０ ) aryl, 5- to 6-membered heteroaryl, and 9- to 10-membered heteroaryl, and R ２ is optionally substituted in one or more occurrences of R Ｂ as defined in any one of claims 1 to 5, a compound according to any one of claims 1 to 5.

7. R ２ is [Chemical Formula 5] selected from, R ２ where R is optionally replaced by one or more occurrences of R as defined in any one of claims 1 to 6 Ｂ ​ The compound according to any one of claims 1 to 6.

8. R ２ is 【Chemical Formula 6】 selected from, R ２ where R Ｂ is optionally replaced by one or more occurrences of R, each R Ｂ being independently selected from the group consisting of halo, -NH ２ , -O(C １ ~C ３ )alkyl, -(C １ ~C ３ )alkyl, -(C ３ ~C ６ )cycloalkyl, -SF ５ and -NO ２ and each occurrence of -O(C １ ~C ３ )alkyl, -(C １ ~C ３ )alkyl, and -(C ３ ~C ６ )cycloalkyl is optionally replaced by one or more groups independently selected from halo and -CF ３ . The compound according to any one of claims 1 to 7.

9. R Ｂ the presence of at least one of -SF ５ is a compound according to any one of claims 1 to 8.

10. R ２ is 【Chemical Formula 7】 The compound according to any one of claims 1 to 9, which is

11. R １ is selected from -H, -(C １ ~C ３ )alkyl, -(C ３ ~C ６ )cycloalkyl, -(C ５ ~C ７ )cycloalkenyl, -(C ６ ~C １０ )aryl, 4- to 9-membered heterocycloalkyl, 6-membered heterocycloalkenyl, 5- to 6-membered heteroaryl, and 9- to 10-membered heteroaryl, and R １ is optionally substituted in one or more occurrences of R Ａ as defined in any one of claims 1 to 10, a compound according to any one of claims 1 to 10.

12. R １ is [Chemical 8] selected from, R １ where R is optionally replaced by one or more occurrences of R as defined in any one of claims 1 to 11 Ａ ​ The compound according to any one of claims 1 to 11.

13. R １ is [Chemical Formula 9] selected from, R １ is optionally replaced by one or more occurrences of R Ａ , and each R Ａ is independently selected from the group consisting of - halo, - OH, - NH ２ , oxo, - (C １ ~C ３ ) alkyl, - C(O)R'', and - O(C １ ~C ３ ) alkyl, and each occurrence of (C １ ~C ３ ) alkyl may be optionally replaced by one or more halo groups, and each R'' is independently selected from methyl, phenyl optionally substituted with - OCF ３ and tetrahydrofuranyl, The compound according to any one of claims 1 to 12.

14. R １ is selected from -(C ４ ~C ８ ) cycloalkenyl, -(C ６ ~C １０ ) aryl, 7- to 10-membered polycyclic (e.g., bicyclic) heterocycloalkyl, 5- to 8-membered heterocycloalkenyl, and 7- to 10-membered polycyclic (e.g., bicyclic) heteroaryl, and R １ is optionally substituted in one or more occurrences of R Ａ as defined in any one of claims 1 to 13, or R １ is -(C ２ ~C １ ~C ３ ) alkyl substituted by one or more substituents selected from -OH, -NH １ ~C ６ ) alkyl, the compound according to any one of claims 1 to 13.

15. L １ is directly bonded or -CH ２ - and is the compound according to any one of claims 1 to 14.

16. Formula (II) 【Chemical 10】 or a pharmaceutically acceptable salt thereof, wherein R １ 、L １ 、R ３ 、R ４ and R ５ are as defined in any one of claims 1 to 15, R ２ is selected from -(C ３ ~C ６ ) cycloalkyl (e.g., cyclopropyl), -(C ６ ~C １０ ) aryl, 5- to 10-membered heterocycloalkyl, and 5- to 10-membered heteroaryl, and R ２ is optionally substituted by one or more occurrences of R Ｂ , and each R Ｂ is independently selected from the group consisting of halo, -OH, oxo, -NO ２ , -NH ２ , -NHMe, -CN, -SF ５ , -SO ２ CH ３ , -NHCOMe, -SiMe ３ , -(C １ ~C ３ ) alkyl optionally substituted with one or more halos, -O(C １ ~C ３ ) alkyl optionally substituted with one or more halos, -(C ３ ) cycloalkyl optionally substituted with -CF ３ ~C ６ , phenyl optionally substituted with one or more halos, -OH, or -CF ３ , benzyl optionally substituted with a halo, and 1-λ ６ -2-thiazolidine-1,1-dionyl, Furthermore, when R ２ is cyclopropyl, R ２ is optionally substituted at one ring atom by a spirocyclic oxindolyl group, E is -C(O)- or -S(O)- ２ - A compound of formula (II) or a pharmaceutically acceptable salt thereof.

17. Formula (III) 【Chemical 11】 or a pharmaceutically acceptable salt thereof, wherein R １ is -H, -(C １ ~C ３ )-alkyl, -(C ４ ~C ６ )-cycloalkyl, -(C ５ ~C ７ )-cycloalkenyl, -(C ６ ~C １０ )-aryl, or 4- to 9-membered heterocycloalkyl, 6-membered heterocycloalkenyl, 5- to 6-membered heteroaryl, and 9- to 10-membered heteroaryl, and R １ is optionally substituted by one or more R Ａ s, and each R Ａ is independently selected from halo, -OH, oxo, -NH ２ , -NHMe, -C(O)OH, -C(O)Me, -SO ２ CH ３ , -NHC(O)R'', -(C １ ~C ３ )-alkyl, -O(C １ ~C ３ )-alkyl, cyclopropyl, oxetanyl, sulfolanyl, phenyl, benzyl, and pyridyl, and each occurrence of -(C １ ~C ３ )-alkyl, -O(C １ ~C ３ )-alkyl and phenyl is optionally substituted by one or more groups independently selected from halo, -OH and -NH ２ s, each R’’ is independently selected from methyl and tetrahydrofuranyl, L １ is directly bonded or -CH ２ - and is R ２ is selected from -(C ３ ~C ６ ) cycloalkyl, -(C ６ ~C １０ ) aryl, 5- to 6-membered heterocycloalkyl and 5- to 10-membered heteroaryl, R ２ is optionally substituted by one or more occurrences of R Ｂ , and each R Ｂ is halo, -NO ２ , -NH ２ , -NHMe, -NHAc, -O(C １ ~C ３ ) alkyl, -SF ５ , -SiMe ３ , -(C １ ~C ３ ) alkyl, 1-λ ６ -2-thiazolidine-1,1-dionyl, phenyl, benzyl, and -(C ３ ) cycloalkyl optionally substituted with -CF ３ ~C ６ ), independently selected from the group consisting of; each occurrence of -(C １ ~C ３ ) alkyl, -O(C １ ~C ３ ) alkyl, phenyl and benzyl is optionally substituted by one or more groups independently selected from halo, -NH ２ and -CF ３ ; and further, when R ２ is cyclopropyl, R ２ is optionally substituted at one ring atom by a spirocyclic oxindolyl group. A compound of formula (III) or a pharmaceutically acceptable salt thereof.

18. Formula (IV) 【Chemical 12】 or a pharmaceutically acceptable salt thereof, wherein R １ and L １ are as defined in any one of claims 1 to 17, p is 1, 2, 3, 4, or 5, Each R Ｂ is independently selected from the group consisting of halo, -NO ２ , -NH ２ , -NHMe, -NHAc, -OCH ３ , -OCF ３ , -SF ５ , SiMe ３ , (C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl, 1-λ ６ -2-thiazolidine-1,1-dionyl, phenyl, and -CF ３ optionally substituted with -(C ３ ~C ６ )cycloalkyl, and each occurrence of -(C １ ~C ３ )alkyl, -O(C １ ~C ３ )alkyl and phenyl is optionally substituted by one or more groups independently selected from halo, -NH ２ and -CF ３ . A compound of formula (IV) or a pharmaceutically acceptable salt thereof.

19. Formula (V) 【Chemical 13】 or a pharmaceutically acceptable salt thereof, wherein R １ and L １ are as defined in any one of claims 1 to 18, R Ｂ１ is -H, or is selected from the group consisting of halo (e.g., -F, or -Cl), -OH, -NH ２ , -NHMe, -NHAc, and -NO ２ and is either one of them R Ｂ２ is selected from the group consisting of halo (e.g., -Br), -SF ５ , -SO ２ CH ３ , -SiMe ３ , -(C １ ~C ３ )alkyl optionally substituted with one or more halo groups, -O(C １ ~C ３ )alkyl optionally substituted with one or more halo groups, 1-trifluoromethylcyclopropan-1-yl, and phenyl optionally substituted with one or more groups independently selected from halo, or -NH ２ ​ A compound of formula (V) or a pharmaceutically acceptable salt thereof.

20. R Ｂ２ is - SF ５ The compound according to claim 19, wherein

21. Formula (VIII), (IX) or (X) 【Chemical Formula 14】 or a pharmaceutically acceptable salt thereof, wherein R １ , R ３ , R ５ and n are as defined in any one of claims 1 to 20, a compound of formula (VIII), (IX) or (X) or a pharmaceutically acceptable salt thereof.

22. -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydrofuran-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, - [4-[2-(4-Piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - trans-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - cis-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - cis-[4-[2-(4-Aminocyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - 1-[3-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]azetidin-1-yl]ethanone, - [4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, - [4-[2-(1-Methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [4-(2-Methyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [4-[2-(3-Methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - 5-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one, - [4-(Trifluoromethoxy)phenyl]-[4-[2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, - [4-(3H-Imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [4-[2-(Oxetan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2,2-dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, - [4-[2-(Azetidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [4-(2-Morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [4-[2-(1-Methylpyrrolidin-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [4-(2-Tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(6,6-dimethyltetrahydropyran-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, - [4-[2-(2,2-Dimethyltetrahydropyran-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [4 - [2 - (6,6 - Dimethyltetrahydropyran - 3 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone, - [4 - [2 - (1,4 - Dioxan - 2 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone, - [4 - (2 - Tetrahydrofuran - 2 - yl - 3H - imidazo[4,5 - b]pyridin - 7 - yl) - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone, - [4 - [2 - (4 - Methylmorpholin - 2 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone, - [2 - Amino - 4 - (trifluoromethoxy)phenyl] - [4 - [2 - (5,5 - Difluoro - 3 - piperidyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl]methanone, - [2 - Amino - 4 - (trifluoromethoxy)phenyl] - [4 - [2 - [1 - (2,2 - Difluoroethyl) - 4 - piperidyl] - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl]methanone, - [4 - [2 - [1 - (2,2 - Difluoroethyl)azetidin - 3 - yl] - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone, - [4 - [2 - (Oxetan - 3 - ylmethyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone, - (4 - Chloro - 1H - indol - 7 - yl) - [4 - (2 - Tetrahydropyran - 4 - yl - 3H - imidazo[4,5 - b]pyridin - 7 - yl) - 1 - piperidyl]methanone, -[2-Nitro-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, - [4 - [2 - (Tetrahydrofuran - 3 - ylmethyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone, - [4 - [2 - (Oxepan - 4 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[4-[2-(2-Oxaspiro[3.3]heptane-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, -[4-(1,1,2,2,2-Pentafluoroethyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -[4-(Pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -(cis)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)cyclohexyl]methanone, -(trans)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)cyclohexyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-oxaspiro[3.3]heptane-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxetan-3-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, -(4-Methoxy-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, -6-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-3-(trifluoromethyl)-1H-pyridin-2-one, -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(2,2,2-trifluoroethyl)phenyl]methanone, -[4-(trifluoromethoxy)phenyl]-[4-[2-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, - [4-(2-Tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, - (3-Methoxy-1-bicyclo[1.1.1]pentanyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, - [4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]methanone, - [4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-[1-(trifluoromethyl)cyclopropyl]phenyl]methanone, - [4-[2-(5,5-Difluoro-3-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(tetrahydropyran-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone, - [4-(2-Pyrrolidin-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [4-[2-[(1-Methyl-4-piperidyl)methyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone, - [4-[2-(Tetrahydropyran-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, - [4-(2-Tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, and - [4-[2-[1-(2,2-Difluoroethyl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone, a compound selected from the group consisting of and pharmaceutically acceptable salts thereof.

23. - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(oxetan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-[2-[Tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(3-Hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[Pyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - 2-Naphthyl-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - 1H-Indazol-3-yl-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]methanone; - (1-Methyl-5-phenyl-pyrazol-3-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(3-Amino-2-naphthyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(2-Amino-3,4,5,6-tetrafluoro-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[1-Isopropyl-2-(trifluoromethyl)benzimidazol-5-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(2-Amino-4-methylsulfonyl-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[3-(1,1-Dioxo-1,2-thiazolidin-2-yl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-(3-Hydroxyphenyl)cyclopropyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -2-[2-Chloro-4-(trifluoromethyl)phenoxy]-1-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]propan-1-one; -(3-Phenylcyclopentyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-Hydroxy-1-[2-(trifluoromethyl)phenyl]pyrazol-3-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[5,5-Difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[3-Amino-4-phenyl-5-(trifluoromethyl)-2-thienyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(7-Hydroxy-1H-indol-2-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(1-Cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -1-[4-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1-piperidyl]ethanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)cyclohexyl]methanone; -1-[4-[7-[1-[2-Amino-4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-1-piperidyl]ethanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-Cyclohexyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1,4-dioxan-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -2-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]benzothiophene-5-carbonitrile; -(5-Amino-1-phenyl-pyrazol-4-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -2-[2-Oxo-2-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]ethyl]-4H-1,4-benzoxazin-3-one; -1-(3,4-Difluorophenyl)-4-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]pyrrolidin-2-one; -[4-(3-Chloro-4-fluoro-phenyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(7-Amino-2-methyl-pyrazolo[1,5-a]pyrimidin-6-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -1-[(2-Chlorophenyl)methyl]-4-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]pyrrolidin-2-one; -1-(4-Fluorophenyl)-4-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]pyrrolidin-2-one; -[1-[(2-Chlorophenyl)methyl]pyrazol-4-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Aminophenyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(3,6-Dichloroimidazo[1,2-a]pyridin-2-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(4-Amino-1-ethyl-pyrazol-3-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(3-Aminoquinoxalin-2-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -2-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]spiro[cyclopropane-1,3'-indoline]-2'-one; - [1-(2-Chlorophenyl)pyrrolidin-3-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - (2-Amino-4,5-dichloro-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [1-(4-Fluorophenyl)imidazol-4-yl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1-hydroxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-cyclohexyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxypropyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-[2-(3-Amino-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(3-Amino-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; - (trans)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)cyclohexyl]methanone; - [3-Fluoro-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[(4-Methylpiperazin-1-yl)methyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-[2-(5-Chloro-2-hydroxy-phenyl)thiazol-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[2-(2-Fluoro-5-hydroxy-phenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -N-[3-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]phenyl]tetrahydrofuran-2-carboxamide; -[4-[2-[5-(Hydroxymethyl)isoxazol-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -1-Ethyl-3-hydroxy-6-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]quinoxalin-2-one; -[3-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -(4-Bromophenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1,4-dioxan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - 4-[7-[1-[2-Amino-4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]cyclohexanone; - [4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-(4-trimethylsilylphenyl)methanone; - (cis)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - (trans)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - (trans)-[4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - (cis)-[4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - (trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - (cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - (2,2-Difluoro-1,3-benzodioxol-5-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(4-Bromo-1H-indol-7-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-(trifluoromethyl)-1H-indol-6-yl]methanone; -[4-(Cyclopropoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[5,5-difluoro-3-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(trifluoromethoxy)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -2-Tetrahydropyran-4-yl-7-[1-[4-(trifluoromethoxy)phenyl]sulfonyl-4-piperidyl]-3H-imidazo[4,5-b]pyridine; -[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-[rac-(2R,3S)-3-aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -(cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[3-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-methylmorpholin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-[2-[6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[6,6-Dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-[2-(7-Oxa-4-azaspiro[2.5]octan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[6,6-dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[6,6-dimethylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-[2-[1-(oxetan-3-yl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-(2-Morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1-(oxetan-3-yl)-4-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-3-fluoro-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [4-[2-[rac-(2R,3S)-3-aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; - (cis)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)cyclohexyl]-[4-(trifluoromethoxy)-1-piperidyl]methanone; - (trans)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)cyclohexyl]-[4-(trifluoromethoxy)-1-piperidyl]methanone; - [4-[2-(4-amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; - (trans)-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(7-oxa-4-azaspiro[2.5]octan-6-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-(2-Cyclopent-3-en-1-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - (2-Amino-4-bromo-phenyl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [4-[2-(4-Amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - N-[2-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-5-(trifluoromethoxy)phenyl]acetamide; - (trans)-[4-[2-(3-Methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(1,2,3,6-Tetrahydropyridin-5-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[4-Phenylpyrrolidin-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[4-Fluoropyrrolidin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(2-Amino-3,3,3-trifluoro-propyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[6-(Aminomethyl)-3-pyridyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4 - [2 - [rac-(3R,4S)-4-(4 - pyridyl)pyrrolidin - 3 - yl] - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - (3 - amino - 2 - bicyclo[2.2.1]hept - 5 - enyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - [pyrrolidin - 2 - yl] - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - (3 - amino - 2 - thienyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - 4 - [7 - [1 - [4 - (trifluoromethoxy)benzoyl] - 4 - piperidyl] - 3H - imidazo[4,5 - b]pyridin - 2 - yl]piperidine - 4 - carbonitrile; - [4 - [2 - [2 - piperidyl] - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - (4 - aminotetrahydropyran - 4 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - (3 - amino - 4 - methoxy - phenyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - (2 - piperidyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - [pyrrolidin - 2 - yl] - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - (1,2,3,4 - tetrahydroisoquinolin - 6 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4-[2-(3-Amino-5-hydroxy-phenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(1H-Indol-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(4,5,6,7-Tetrahydrothieno[3,2-c]pyridin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(Azetidin-2-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; 2,2,2-Trifluoroacetic acid - [4-[2-(3-Oxa-9-azabicyclo[3.3.1]nonan-7-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(4-Amino-3-pyridyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[Piperazin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(3-Aminocyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[3-(Methylamino)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(2-Azabicyclo[4.1.0]heptan-7-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[4-Hydroxy-6-(trifluoromethyl)-3-quinolyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4 - [2 - (3 - Oxabicyclo[3.1.0]hexan - 6 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - N - [4 - Hydroxy - 2 - [7 - [1 - [4 - (trifluoromethoxy)benzoyl] - 4 - piperidyl] - 3H - imidazo[4,5 - b]pyridin - 2 - yl]phenyl]acetamide; - 5,6 - Dimethyl - 3 - [7 - [1 - [4 - (trifluoromethoxy)benzoyl] - 4 - piperidyl] - 3H - imidazo[4,5 - b]pyridin - 2 - yl] - 1H - pyridin - 2 - one; - 1 - [3,5 - Dimethyl - 4 - [7 - [1 - [4 - (trifluoromethoxy)benzoyl] - 4 - piperidyl] - 3H - imidazo[4,5 - b]pyridin - 2 - yl] - 1H - pyrrol - 2 - yl]ethanone; - [4 - [2 - [1 - (1,1 - dioxothiolan - 3 - yl) - 4 - piperidyl] - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - (1 - Methylsulfonylazetidin - 3 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [2 - Hydroxy - 4 - (trifluoromethoxy)phenyl] - [4 - (2 - tetrahydropyran - 4 - yl - 3H - imidazo[4,5 - b]pyridin - 7 - yl) - 1 - piperidyl]methanone; - [4 - [2 - (1,4 - Oxazepan - 2 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [2 - [4 - Hydroxy - 4 - (trifluoromethyl)cyclohexyl] - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - (1,1,2,2 - Tetrafluoroethoxy)phenyl] - [4 - (2 - tetrahydropyran - 4 - yl - 3H - imidazo[4,5 - b]pyridin - 7 - yl) - 1 - piperidyl]methanone; - [4-(1,1,2,2,2-Pentafluoroethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [4-(2-Phenyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - (2,2,3,3-Tetrafluoro-1,4-benzodioxin-6-yl)-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [4-[2-[4-Hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[7-oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-[2-[rac-(1S,3S)-3-Aminocyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-(2-Cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(4-Methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[7-oxa-4-azaspiro[2.5]octan-6-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-cyclopent-3-en-1-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [4-[2-(Azepan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [4-[2-[4-Amino-1-methyl-2-oxabicyclo[2.1.1]hexan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(3-Hydroxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-[rac-(1R,3S)-3-Aminocyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; - [4-[2-(3-Fluoro-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(1,2,3,6-Tetrahydropyridin-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - 3-[7-[1-[4-(Trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]bicyclo[1.1.1]pentane-1-carboxylic acid; - 3-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)piperidine-1-carbonyl]-6-(trifluoromethyl)-1H-pyridin-2-one; - [4-(Difluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1,1-dioxothiolan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-[2-[1,4-oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[1,4-oxazepan-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; - (Trans)-4-[7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]cyclohexanecarboxylic acid; - (Cis)-[4-[2-[3-aminotetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-amino-4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(1,1-dioxothiolan-3-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4-[2-(4-hydroxy-4-methyl-cyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(4-hydroxy-4-methyl-cyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-(1,2,3,6-tetrahydropyridin-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-[2-[Azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[2-[Azepan-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(2-Cyclopentyl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(trans)-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(Pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(Pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-(Pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; hydrochloride; -[4-[2-[Morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-N-Morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-N-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(trans)-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[2-(1-Methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[2-(1-Cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[2-[Morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(cis)-[4-[2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(1-cyclopropyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-(methylamino)-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(1-methyl-4-piperidyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[2-[4-Methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[4-[2-(4-Hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[2-[4-Methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(Pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-Tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[4-[2-[2-Oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -3-Methyl-3-[7-[1-[4-(pentafluoro-λ ６ -sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]cyclobutanone; -[4-[2-(1-Hydroxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(1-hydroxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[(cis)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[(trans)-2-Methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-[2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-fluoro-4-(6-fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(3-Hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(3-hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(Pentafluoro-λ ６ -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[2-Hydroxy-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[(cis)-2-methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[(trans)-2-methyl-4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)azepan-1-yl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(Pentafluoro-λ ６ -sulfanyl)phenyl]-[3-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-1-yl]methanone; -[4-(6-Fluoro-2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(cis)-[4-[2-(3-Hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Fluoro-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -(trans)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(cis)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-(6-Fluoro-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(oxepan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydrofuran-3-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-[6-Methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-(6-Fluoro-2-tetrahydrofuran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(6-fluoro-2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-[4-(hydroxymethyl)-1-piperidyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-(6-Fluoro-2-tetrahydropyran-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(trans)-[4-[6-Fluoro-2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[2-oxa-5-azabicyclo[2.2.1]heptan-1-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[2-[3-Methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-(6-Fluoro-2-thiomorpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(trans)-[4-[6-Fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(1-methoxy-1-methyl-ethyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-[6-methylmorpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-[tetrahydrofuran-3-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[morpholin-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -5-[6-Fluoro-7-[1-[4-(pentafluoro-λ ６ -sulfanyl)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]piperidin-2-one; -(trans)-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-cyclopentyl-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-[3-methoxycyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-[oxepan-4-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-[6-Fluoro-2-[tetrahydrofuran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[4-[6-Fluoro-2-(3-hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-hydroxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(2-Cyclopentyl-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; - [4-[6-Fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[4-[6-Fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(3-methoxy-1-bicyclo[1.1.1]pentanyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - [4-[6-Fluoro-2-(2-oxabicyclo[2.2.2]octan-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; -[2-Amino-5-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-(2-tetrahydropyran-4-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]methanone; -[4-[2-(1-Cyclopropyl-4-piperidyl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; - [2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-[tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -[4-(6-Fluoro-2-morpholin-2-yl-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[2-hydroxy-4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; - [4-[6-Fluoro-2-[3-(trifluoromethyl)-1-bicyclo[1.1.1]pentanyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(trifluoromethoxy)phenyl]methanone; - [4 - [2 - (1 - methoxy - 1 - methyl - ethyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; -[4-[6-Fluoro-2-[tetrahydropyran-2-yl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(4-hydroxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - (cis) - [4 - [6 - fluoro - 2 - (4 - methoxycyclohexyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - (trans) - [4 - [6 - fluoro - 2 - (4 - methoxycyclohexyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - [4 - [6 - fluoro - 2 - (1 - methoxy - 1 - methyl - ethyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - (trans) - (4 - (6 - fluoro - 2 - (4 - hydroxy - 4 - methylcyclohexyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl)piperidin - 1 - yl)(4 - (pentafluoro - λ6 - sulfanyl)phenyl)methanone; -(cis)-[4-[6-Fluoro-2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; - [2 - amino - 4 - (trifluoromethoxy)phenyl] - [4 - [6 - fluoro - 2 - (1 - methoxy - 1 - methyl - ethyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl]methanone; -(trans)-[4-[6-Fluoro-2-(3-hydroxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -4-(6-Fluoro-2-N-morpholino-3H-imidazo[4,5-b]pyridin-7-yl)-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(trans)-[4-[6-Fluoro-2-[4-hydroxy-4-(trifluoromethyl)cyclohexyl]-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; - [2 - amino - 4 - (trifluoromethoxy)phenyl] - [4 - [6 - fluoro - 2 - (2 - oxabicyclo[2.2.2]octan - 4 - yl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl]methanone; -[4-[2-(3,4,4a,5,7,7a-Hexahydro-2H-furo[3,4-b][1,4]oxazin-2-yl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; -(trans)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(cis)-[2-Amino-4-(pentafluoro-λ ６ -sulfanyl)phenyl]-[4-[6-fluoro-2-(3-methoxycyclobutyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; - 2 - [6 - fluoro - 7 - [1 - [4 - (pentafluoro - λ6 - sulfanyl)benzoyl] - 4 - piperidyl] - 3H - imidazo[4,5 - b]pyridin - 2 - yl] - 2,3,4a,5,7,7a - hexahydrofuro[3,4 - b][1,4]oxazine - 4 - carboxylic acid; -[4-[2-(1,1-Dioxido-1,4-thiazinan-2-yl)-6-fluoro-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]-[4-(pentafluoro-λ ６ -sulfanyl)phenyl]methanone; - [4 - [6 - fluoro - 2 - (3 - methoxycyclobutyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl] - [4 - (trifluoromethoxy)phenyl]methanone; - (2 - amino - 4 - (trifluoromethoxy)phenyl] - [4 - [6 - fluoro - 2 - (3 - methoxycyclobutyl) - 3H - imidazo[4,5 - b]pyridin - 7 - yl] - 1 - piperidyl]methanone; -(cis)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; -(trans)-[2-Amino-4-(trifluoromethoxy)phenyl]-[4-[6-fluoro-2-(4-methoxycyclohexyl)-3H-imidazo[4,5-b]pyridin-7-yl]-1-piperidyl]methanone; and -7-[6-Fluoro-7-[1-[4-(trifluoromethoxy)benzoyl]-4-piperidyl]-3H-imidazo[4,5-b]pyridin-2-yl]-2-oxa-5-azaspiro[3.5]nonane-5-carboxylic acid A compound selected from the group consisting of and pharmaceutically acceptable salts thereof.

24. The compound has an IC ５０ value of less than about 2 μM, such as less than about 1 μM, 0.5 μM, 0.2 μM, 100 nM or 50 nM, against ERK5, and the compound according to any one of claims 1 to 23.

25. A pharmaceutical composition comprising the compound according to any one of claims 1 to 24 and at least one pharmaceutically acceptable excipient or carrier.

26. The compound according to any one of claims 1 to 24, or the pharmaceutical composition according to claim 25, for use in therapy.

27. The compound according to any one of claims 1 to 24, or the pharmaceutical composition according to claim 25, for use in the treatment or prevention of cancer.

28. The compound or pharmaceutical composition for use according to claim 27, wherein the cancer is characterized by an increase in MAPK7 expression and / or an increase in ERK5 activity.

29. The compound or pharmaceutical composition for use according to claim 27 or claim 28, wherein the cancer is selected from leukemia, breast cancer, multiple myeloma, colon cancer, renal cell carcinoma, mesothelioma, adenocarcinoma, neuroblastoma, and hepatocellular carcinoma.

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