Method for isolating an anti-ligand
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- BIOINVENT INT AB
- Filing Date
- 2023-06-12
- Publication Date
- 2026-06-22
AI Technical Summary
Current methods for isolating anti-ligands with desired binding specificity, particularly for differentially and rarely expressed ligands, are limited in diversity and throughput, often missing rare antibody clones with therapeutic potential due to insufficient screening techniques.
A method involving differential biopanning, high-throughput sequencing, and enrichment signature analysis to identify and isolate anti-ligands with specificity for differentially expressed ligands, using predictive and experimental signatures to enhance the identification of promising clones.
Enables the identification of orders of magnitude more anti-ligands with therapeutic potential, overcoming limitations of existing methods by enhancing diversity and efficiency in screening for anti-ligands against a wide range of ligand expression levels.
Smart Images
Figure 00000000_0000_ABST