D-dimer antibodies and uses thereof

By designing D-dimer antibodies with specific heavy and light chain variable regions, the problem of low antibody binding efficiency in existing detection methods has been solved, achieving efficient and accurate D-dimer detection, which is suitable for the diagnosis and treatment monitoring of various diseases.

CN118255880BActive Publication Date: 2026-06-19FAPON BIOTECH INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FAPON BIOTECH INC
Filing Date
2023-12-21
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing D-dimer detection methods require D-dimer antibodies; however, there is an urgent need to develop an antibody that can effectively bind to D-dimer to improve detection efficiency and accuracy.

Method used

A D-dimer antibody is provided, comprising specific amino acid sequences of heavy chain variable regions and light chain variable regions. By designing primers to construct a mutant library, antibodies that efficiently bind to D-dimers are screened, and corresponding reagents or kits are prepared.

Benefits of technology

It achieves efficient and accurate D-dimer detection, applicable to the early diagnosis of various diseases and monitoring of thrombolytic therapy, and improves the sensitivity and specificity of the detection.

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Abstract

This invention proposes an antibody comprising a heavy chain variable region and a light chain variable region; wherein the heavy chain variable region comprises an amino acid sequence as shown in SEQ ID NO:1 or a variant thereof; and the light chain variable region comprises an amino acid sequence as shown in SEQ ID NO:2 or a variant thereof. The antibody of this invention can specifically bind to D-dimers and can be used for the qualitative or quantitative detection of D-dimers.
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