Compositions and methods for molecular mimicry
The method identifies functional mimetic molecules by evaluating interactions within mutant or variant libraries, addressing the lack of reliability and scalability in existing methods, and enabling the development of effective therapeutic agents and drug discovery tools.
JP2026516959APending Publication Date: 2026-05-27FLAGSHIP PIONEERING INNOVATIONS VII LLC
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Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- FLAGSHIP PIONEERING INNOVATIONS VII LLC
- Filing Date
- 2024-04-12
- Publication Date
- 2026-05-27
AI Technical Summary
Technical Problem
Current methods lack reliability and scalability for identifying mimetic proteins useful as therapeutic agents and drug discovery tools.
Method used
A method for identifying functional mimetic molecules by providing mutant or variant libraries of template molecules, evaluating interactions, and comparing them with candidate mimetic molecules to identify those with a target functional profile.
Benefits of technology
Enables the discovery of mimetic molecules that replicate the functional properties of model ligands, offering a non-zero similarity in structural and energetic interactions, facilitating their use as therapeutic agents and drug discovery tools.
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Abstract
The present invention relates to a method for identifying and characterizing molecules that mimic the binding sites of specific conjugates on various binding surfaces. In an embodiment, the present disclosure provides a method for identifying functional mimetic molecules having a target functional profile that includes one or more functions of a model, comprising: (a) providing one or more mutant libraries of one or more functional template molecules of a model, wherein the mutant library comprises multiple mutants of one or more functional template molecules; (b) providing one or more candidate functional mimetic molecules; (c) evaluating the interactions of the multiple mutant functional template molecules with (i) the model and (ii) one or more candidate functional mimetic molecules, and comparing the evaluations in i) and ii); and (d) identifying one or more functional mimetic molecules having a target functional profile based on the evaluation in c).
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