Systems for aspirating and irrigating a body cavity, and related devices and methods

Abstract

Disclosed herein are systems, and related devices and methods, for aspirating, irrigating, and / or mechanically destroying a body cavity, such as an abdominal abscess, abscess, and / or (e.g., complicated) pleural effusion. In some embodiments, the aspiration and irrigation system includes an inner catheter defining an aspiration lumen and an outer tube positioned coaxially around the inner catheter and defining an irrigation lumen. A distal portion of the outer tube can be joined to the inner catheter, and multiple apertures can be formed through the outer tube proximal to the junction. The aspiration lumen can be fluidly connected to an aspiration circuit configured to draw aspiration through the aspiration lumen, and the irrigation lumen can be fluidly connected to an irrigation circuit configured to flow irrigation fluid through the irrigation lumen and out of the apertures.

Description

[Technical Field]

[0001] (CROSS-REFERENCE TO RELATED APPLICATIONS) This application claims the benefit of U.S. Provisional Patent Application No. 63 / 383,440, filed November 11, 2022, entitled "SYSTEMS FOR ASPIRATING AND IRRIGATING BODY CAVITIES, AND ASSOCIATED DEVICES AND METHODS," and U.S. Provisional Patent Application No. 63 / 426,560, filed November 18, 2022, entitled "SYSTEMS FOR ASPIRATING AND IRRIGATING BODY CAVITIES, AND ASSOCIATED DEVICES AND METHODS," each of which is incorporated by reference herein in its entirety.

[0002] FIELD OF THE INVENTION The present technology relates generally to systems for aspirating, irrigating, and / or mechanically destroying material within a body cavity, such as an abdominal abscess, an abscess, and / or a (eg, complicated) pleural effusion. [Background technology]

[0003] Abdominal abscesses and pleural effusions are collections of low-viscosity, sterile, serous-blood-like fluid that fill a body cavity. If the collection is large enough, percutaneous drainage can be performed to drain the contents of the collection. Drainage is typically performed using an indwelling percutaneous drainage catheter, which is typically left in place for less than a week for uncomplicated collections. As the disease state progresses further, pleural effusions can become complicated pleural / parapneumonic effusions or empyema, both of which involve infection of the cavity contents. Intra-abdominal abscesses can also become infected, resulting in more complicated symptoms.

[0004] These complex abdominal abscess collections, pleural effusions, and empyemas can produce thick, viscous pus (purulent fluid) containing debris, blood clots, bowel contents, and / or multiple vesicles. The vesicles are contained within fibrin sheets (e.g., septa) that create distinct fluid-filled pockets within a single cavity. As these disease states progress to complex presentations, the ability of current percutaneous drains to efficiently and completely drain collections becomes significantly more challenging. For example, current indwelling drains are limited by internal lumen size, drainage side hole diameter, number of drainage side holes, strictures (e.g., stopcocks) along the fluid pathway, fluid pathway length, and pressure differentials between the inlet (abscess) and outlet (collection bag). While drains have improved in size, shape, and suction power over time, current technology still struggles to drain complex collections. This is evidenced by the need for multiple drains within the same collection, the need for multiple drain changes due to blockage or malposition, the long duration of drainage (days to months), the use of pharmacological agents to compensate for drainage effectiveness, and the use of off-label devices to make the collection more suitable for percutaneous drainage.

[0005] Several thrombectomy devices have been used off-label for mechanical debridement of the cavity. These devices are not targeted and / or lack precise spatial control. Additionally, pharmacological agents such as tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) have been administered to liquefy the accumulation and accelerate drainage by reducing the viscosity of the fluid; however, most protocols are labor-intensive and time-consuming.

[0006] Furthermore, drainage catheters require daily flushing with a small amount of sterile saline to prevent the catheter from clogging and obstructing flow. Flushing aims to clear the catheter and maintain its patency, while irrigation aims to dislodge debris and reduce the viscosity of local contents within the collection. Irrigation techniques are currently used with drainage catheters. For such techniques, large volumes of sterile saline are flushed through a placed percutaneous drain and immediately aspirated. While this method can effectively clear a clogged drain, it can also return debris already inside the drain to the cavity, potentially clogging the drain again later. Sometimes, using two separate drains within a single cavity can reduce clogging after irrigation. Summary of the Invention [Means for solving the problem]

[0007] The present technology is generally directed to systems and related devices and methods for aspirating, irrigating, and / or mechanically destroying material / contents within a body cavity, such as an abdominal abscess, an abscess, and / or (e.g., complicated) pleural effusion. In some embodiments, an aspiration and irrigation system configured in accordance with the present technology includes an inner catheter defining an aspiration lumen and an outer tube positioned coaxially around the inner catheter and defining an irrigation lumen. A distal portion of the outer tube may be fluid-sealed to the inner catheter, and multiple apertures may be formed through the outer tube proximal to the fluid-sealed portion. The aspiration lumen may be fluidly coupled to an aspiration circuit configured to aspirate the aspiration lumen, and the irrigation lumen may be fluidly coupled to an irrigation circuit configured to flow irrigation fluid through the irrigation lumen and out the apertures. The catheter assembly may be positioned within the body cavity, and the aspiration circuit may be operated to aspirate material from the abscess. At the same time or at a different time, the irrigation circuit may be operated to irrigate the cavity with irrigation fluid, for example, to break down (e.g., fluidize) material within the cavity and / or to reduce the viscosity of material within the cavity.

[0008] In some aspects of the present technology, the aspiration and irrigation system (i) maximizes the area of ​​the aspiration lumen along its entire length, (ii) provides vigorous circumferential irrigation to reduce the viscosity of the cavity contents and break up vesicles and other large debris, and (iii) separates the aspiration and irrigation circuits. The catheter assembly allows the physician to quickly irrigate and aspirate large, complex collections, saving drain administration time and overcoming repeated drain blockages. Complex material can be evacuated using the aspiration and irrigation system during the initial treatment procedure, thus making the collection suitable for drainage using currently available drainage catheters. Alternatively, the aspiration and irrigation system can be used in collections that currently available drainage catheters could not evacuate.

[0009] Aspiration and irrigation systems can be designed to maximize material flow by utilizing Poiseuille's law, defined below. In some embodiments, the pressure differential is maximized by using an aspiration source containing a 60 cc syringe capable of generating a vacuum of -25.5 inHg when fully evacuated. The radius of the aspiration catheter can be maximized by utilizing large-diameter side port tubing and a large-diameter syringe, maintaining a single lumen with the same diameter from the distal tip of the aspiration catheter to the syringe. Fluid viscosity can be reduced through the irrigation process, which can dilute the cavity contents. System length can be minimized by maintaining a minimum distance between the catheter tip and the aspiration source / syringe. In contrast, current drains typically use excessive tubing lengths to connect to gravity collection bags, wall suction, or aspiration valves, which reduces the efficiency of the drain.

[0010] If the contents within the cavity are too viscous or too large for the aspiration catheter, a mechanical element can be used, which can have a size and shape that can be safely controlled to a desired geometry and manipulated within the cavity to aid in subsequent aspiration and drainage. [Brief explanation of the drawings]

[0011] Many aspects of the present technology can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale, emphasis instead being placed upon clearly illustrating the principles of the present disclosure. [Figure 1A] FIG. 1A is a partial schematic side view of an aspiration and irrigation system in accordance with an embodiment of the present technology. [Figure 1B] FIG. 1B is an enlarged side perspective view of a distal portion of a catheter assembly of the system shown in FIG. 1A in accordance with an embodiment of the present technology. [Figure 1C] FIG. 1C is an enlarged, distal-facing perspective view of a distal portion of the catheter assembly shown in FIG. 1A in accordance with an embodiment of the present technology. [Figure 2A] 2A and 2B are a side view and an enlarged partial schematic side view of a pressure source assembly and an irrigation assembly of the system of FIG. 1A in accordance with an embodiment of the present technology. [Figure 2B] 2A and 2B are a side view and an enlarged partial schematic side view of a pressure source assembly and an irrigation assembly of the system of FIG. 1A in accordance with an embodiment of the present technology. [Figure 3A] 3A-3C are enlarged side views of a mechanical disruptor assembly in a compressed position, a partially deployed position, and a deployed position, respectively, in accordance with an embodiment of the present technology, configured to be advanced through the catheter assembly of FIG. 1A into a body cavity to mechanically disrupt material therein. [Figure 3B] 3A-3C are enlarged side views of a mechanical disruptor assembly in a compressed position, a partially deployed position, and a deployed position, respectively, in accordance with an embodiment of the present technology, configured to be advanced through the catheter assembly of FIG. 1A into a body cavity to mechanically disrupt material therein. [Figure 3C]3A-3C are enlarged side views of a mechanical disruptor assembly in a compressed position, a partially deployed position, and a deployed position, respectively, in accordance with an embodiment of the present technology, configured to be advanced through the catheter assembly of FIG. 1A into a body cavity to mechanically disrupt material therein. [Figure 3D] FIG. 3D is a side view of the handle of the mechanical disruptor assembly of FIGS. 3A-3C in accordance with an embodiment of the present technology. [Figure 4] FIG. 4 is a flow diagram of a process or method for treating a body cavity of a patient using the system of FIG. 1A in accordance with an embodiment of the present technology. [Figure 5A] 5A-5E are side cross-sectional views of the distal portion of the catheter assembly of FIG. 1A during different stages of the method of FIG. 4 in accordance with an embodiment of the present technology. [Figure 5B] 5A-5E are side cross-sectional views of the distal portion of the catheter assembly of FIG. 1A during different stages of the method of FIG. 4 in accordance with an embodiment of the present technology. [Figure 5C] 5A-5E are side cross-sectional views of the distal portion of the catheter assembly of FIG. 1A during different stages of the method of FIG. 4 in accordance with an embodiment of the present technology. [Figure 5D] 5A-5E are side cross-sectional views of the distal portion of the catheter assembly of FIG. 1A during different stages of the method of FIG. 4 in accordance with an embodiment of the present technology. [Figure 5E] 5A-5E are side cross-sectional views of the distal portion of the catheter assembly of FIG. 1A during different stages of the method of FIG. 4 in accordance with an embodiment of the present technology. [Figure 6] FIG. 6 is a side view of an aspiration and irrigation system in accordance with an additional embodiment of the present technology. [Figure 7A] 7A is a side view of a catheter assembly of the system of FIG. 6 in accordance with an embodiment of the present technology. [Figure 7B] 7B is a side view of the catheter assembly of FIG. 7A with a dilator inserted in accordance with an embodiment of the present technology. [Figure 8A]8A and 8B are enlarged side views of a distal portion of the elongate member of the catheter assembly of FIG. 6 in accordance with an embodiment of the present technology. [Figure 8B] 8A and 8B are enlarged side views of a distal portion of the elongate member of the catheter assembly of FIG. 6 in accordance with an embodiment of the present technology. DETAILED DESCRIPTION OF THE INVENTION

[0012] To provide a thorough understanding of various embodiments of the present technology, certain details are set forth in the following description and in FIGS. 1-8B . In other instances, to avoid unnecessarily obscuring the description of various embodiments of the present technology, well-known structures, materials, operations, and / or systems often associated with percutaneous procedures, body cavity material removal procedures, catheters, and the like, are not shown or described in detail in the following disclosure. Furthermore, while reference is made primarily to suction and drainage for use in removing material from body cavities, the catheters of the present technology may be other types of catheters and / or may be used in other types of medical procedures. However, one skilled in the art will recognize that the present technology may be practiced without one or more of the details described herein and / or with other structures, methods, components, and the like.

[0013] The terms used below should be interpreted in their broadest reasonable manner, even when used in conjunction with the detailed description of specific examples of embodiments of the present technology. Indeed, certain terms may even be emphasized below; however, any terms intended to be interpreted in any limited manner will be expressly and specifically defined as such in this detailed description section.

[0014] The accompanying drawings depict embodiments of the present technology and are not intended to limit its scope unless explicitly stated. The sizes of various depicted elements are not necessarily drawn to scale, and these various elements may be enlarged to improve readability. Details of components may be abstracted in the figures to exclude details such as the location of components and specific precise connections between such components when such details are not necessary for a complete understanding of how to make and use the present technology. Many of the details, dimensions, angles, and other features shown in the figures are merely illustrative of particular embodiments of the present disclosure. Thus, other embodiments can have other details, dimensions, angles, and features without departing from the present technology. Additionally, those skilled in the art will understand that further embodiments of the present technology can be practiced without some of the details described below.

[0015] With respect to the terms "distal" and "proximal" herein, unless otherwise specified, these terms may refer to the relative position of portions of a catheter subsystem relative to an operator and / or a location within the vasculature. Also, as used herein, designations such as "rear," "forward," "superior," "inferior," etc. are not meant to limit the referenced components to a particular orientation. It is understood that such designations refer to the orientation of the referenced components as illustrated in the figures, and that the systems of the present technology may be used in any orientation suitable to the user.

[0016] As used herein, unless expressly indicated otherwise, terms such as "about," "approximately," and "substantially" mean within ±10% of the stated value. To the extent any material incorporated by reference herein contradicts the present disclosure, the present disclosure controls.

[0017] 1A is a partially schematic side view of an aspiration and irrigation system 100 ("system 100") in accordance with an embodiment of the present technology. In the illustrated embodiment, system 100 includes a catheter assembly 110 fluidly connected to (i) a valve 102, (ii) a first tubing assembly 120 via a first hub 104, and (iii) a second tubing assembly 130 via a second hub 106. System 100 may include some features that are generally similar to or identical to the features of the clot treatment system described in detail in U.S. Patent Application No. 16 / 536,185, filed August 8, 2019, and entitled "SYSTEM FOR TREATING EMBOLISM AND ASSOCIATED DEVICES AND METHODS," which is incorporated herein by reference in its entirety.

[0018] 1B is an enlarged side perspective view of a distal portion of the catheter assembly 110 shown in FIG. 1A in accordance with an embodiment of the present technology. In the illustrated embodiment, the catheter assembly 110 extends along an axis L (e.g., a longitudinal axis) and includes an inner elongate member 112 (which may also be referred to as an inner sheath, inner tube, inner catheter, suction member, suction sheath, suction tube, suction catheter, etc.) and an outer elongate member 114 (which may also be referred to as an outer sheath, outer tube, outer catheter, irrigation member, irrigation sheath, irrigation tube, irrigation catheter, etc.) positioned at least partially coaxially around the inner elongate member 112. The outer elongate member 114 is shown as partially transparent in FIG. 1B for clarity. The inner elongate member 112 may be a reinforced, thin-walled catheter. In some embodiments, the inner elongate member 112 may include some features that are at least broadly similar in structure and function to or identical in structure and function to the features of catheters disclosed in (i) U.S. Patent Application Publication No. 17 / 529,018, entitled "CATHETERS HAVING SHAPED DISTAL PORTIONS, AND ASSOCIATED SYSTEMS AND METHODS," filed November 17, 2021, and / or (ii) U.S. Patent Application Publication No. 17 / 529,064, entitled "CATHETERS HAVING STEERABLE DISTAL PORTIONS, AND ASSOCIATED SYSTEMS AND METHODS," filed November 17, 2021, each of which is incorporated herein by reference in its entirety. The outer elongate member 114 may be a tube formed from a plastic, elastomeric, and / or thermoplastic elastomer (TPE) material, such as a TPE manufactured by Arkema SA (Colombes, France), such as a TPE manufactured under the trademark "Pebax." In other embodiments, the outer elongate member 114 may be a reinforced thin-walled catheter.The outer elongate member 114 can have a size of approximately 6 to 30 French, such as a size of 6 French, 8 French, 12 French, 16 French, 20 French, 24 French, 26 French, or 30 French. The inner elongate member 112 can have a smaller size than the outer elongate member 114, for example, a size of approximately 1 to 8 French smaller than the outer elongate member 114.

[0019] 1C is an enlarged, distal-facing perspective view of a distal portion of catheter assembly 110 in accordance with an embodiment of the present technology. With reference to FIGS. 1B and 1C, distal end portion 115a of outer elongate member 114 may be fluidly sealed (e.g., coupled, mechanically attached, bonded, affixed, etc.) to / with respect to distal portion 113a (e.g., distal end portion) of inner elongate member 112. With reference to FIG. 1A, proximal end portion 113b of inner elongate member 112 may be coupled (e.g., bonded) to first hub 104 and / or valve 102, and proximal end portion 115b of outer elongate member 114 may be coupled (e.g., bonded) to second hub 106.

[0020] With reference to FIG. 1B , the inner elongate member 112 defines an inner lumen 111 (e.g., an aspiration lumen), and the outer elongate member 114 defines an outer lumen 117 (e.g., an irrigation lumen). The inner lumen 111 is accessible at a distal portion 113a of the inner elongate member 112 via a distal opening 119 (e.g., an aspiration opening). With reference to FIGS. 1B and 1C , the distal end portion 115a of the outer elongate member 114 includes / defines one or more (e.g., multiple) circumferentially distributed apertures 118 (e.g., holes) fluidly coupled / connected to the outer lumen 117. As described in more detail below, the apertures 118 can function as outlets for irrigation fluid, a target drug, and / or another fluid to flow from the outer lumen 117 to the outside of the catheter assembly 110. In the illustrated embodiment, the apertures 118 have a circular shape. The size of apertures 118, the shape of apertures 118, the gap between outer elongate member 114 and inner elongate member 112, and / or the lumen diameter of second tubing assembly 130 ( FIG. 1A ), including tubing sections 132a-b and fluid control device 134, can be controlled (e.g., selected) to enable a forceful injection of irrigation fluid through apertures 118. Additionally, the number of apertures 118, the size of apertures 118, and the shape of apertures 118 (e.g., circular, square, rectangular, rectilinear, polygonal, irregular, etc.) can be adjusted to adjust the jet fluid angle of irrigation fluid exiting apertures 118. In some embodiments, distal openings 119 extend in a plane orthogonal to axis L, and apertures 118 extend along a plane different from the plane of distal openings 119 (e.g., a plane orthogonal to distal openings 119). In some embodiments, the aperture 118 is fluidly connected / connected to the outer lumen 117 at the distal end portion 115a of the outer elongate member 114, where the distal end portion 115a (the fluidly connected / connected portion) extends proximally such that the distance between the distal opening 119 and the aperture 118 is longer.

[0021] 1A-1C , inner lumen 111 is fluidly connected to first tubing assembly 120 via first hub 104, and outer lumen 117 is fluidly connected to second tubing assembly 130 via second hub 106. Valve 102 is fluidly connected to inner lumen 111 of inner elongate member 112. In some embodiments, valve 102 is an actuated access valve configured to maintain fluid control during a body cavity treatment procedure by blocking or preventing proximal fluid flow through valve 102 as various components, such as delivery sheaths, tensioning members, guidewires, interventional devices, mechanical disruptor assemblies, other aspiration catheters, etc., are inserted through valve 102 and delivered through inner elongate member 112 to a treatment site in the body cavity. In some embodiments, the valve 102 may be a valve of the type disclosed in U.S. Patent Application No. 16 / 117,519, filed August 30, 2018, entitled "HEMOSTASIS VALVES AND METHODS OF USE," which is incorporated herein by reference in its entirety.

[0022] In the illustrated embodiment, the first tubing assembly 120 fluidly connects the inner lumen 111 of the inner elongate member 112 of the catheter assembly 110 to a pressure source assembly 140, such as a syringe and one or more valves, as described in detail below with reference to Figures 2A and 2B. Similarly, the second tubing assembly 130 fluidly connects the outer lumen 117 of the outer elongate member 114 to an irrigation assembly 150, such as a syringe and one or more valves, as described in detail below with reference to Figures 2A and 2B. Referring to Figure 1A, the first tubing assembly 120 and the second tubing assembly 130 ("tubing assemblies 120, 130") may be broadly similar or identical. For example, in the illustrated embodiment, first tubing assembly 120 may include one or more tubing sections 122 (individually labeled as first tubing section 122a and second tubing section 122b), at least one fluid control device 124 (e.g., a valve), and at least one connector 126 (e.g., a Toomey tip connector) for fluidly connecting first tubing assembly 120 to pressure source assembly 140 and / or other suitable components. Similarly, in the illustrated embodiment, second tubing assembly 130 may include one or more tubing sections 132 (individually labeled as first tubing section 132a and second tubing section 132b), at least one fluid control device 134 (e.g., a valve), and at least one connector 136 (e.g., a Toomey tip connector) for fluidly connecting second tubing assembly 130 to irrigation assembly 150 and / or other suitable components. 1A and 1B, in some embodiments, fluid control device 124 comprises a stopcock fluidly connected (i) to inner lumen 111 of inner elongate member 112 via second tubing section 122b and (ii) to connector 126 via first tubing section 122a. Similarly, fluid control device 134 may comprise a stopcock fluidly connected (i) to outer lumen 117 of outer elongate member 114 via second tubing section 132b and (ii) to connector 136 via first tubing section 132a.Fluid control devices 124, 134 are externally operable by a user to regulate the flow of fluid therethrough, specifically from irrigation assembly 150 to inner lumen 111 of catheter assembly 110, to pressure source assembly 140, and to outer lumen 117, respectively. In some embodiments, connectors 126, 136 are quick-release connectors (e.g., quick-disconnect fittings) that allow for rapid connection / disconnection of catheter assembly 110 from pressure source assembly 140 and / or irrigation assembly 150.

[0023] The system 100 can further include a dilator 108 insertable through the inner lumen 111 of the inner elongate member 112 via the valve 102. The dilator 108 can include a proximal connecting portion 109 configured to secure to and / or mate with a corresponding portion of the valve 102. In some embodiments, the dilator 108 and / or the valve 102 can be of the type disclosed in U.S. Patent Application No. 18 / 156,944, filed January 19, 2023, and entitled "CLOT TREATMENT SYSTEMS WITH DILATOR LOCKING MECHANISMS, AND ASSOCIATED DEVICES AND METHODS," which is incorporated herein by reference in its entirety.

[0024] 2A and 2B are side and enlarged partial schematic side views of pressure source assembly 140 and irrigation assembly 150 in accordance with an embodiment of the present technology. Referring to FIGS. 2A and 2B, pressure source assembly 140 includes a pressure source 242, such as a syringe 242 having a barrel 243 and a plunger 244 slidable through barrel 243, and an aspiration flow control assembly 245 fluidly coupled to barrel 243. Aspiration flow control assembly 245 can include (i) a first connector 246, (ii) a second connector 247 (obscured in FIG. 2A ), (iii) a first one-way valve 248 (shown schematically in FIG. 2B ) fluidly connecting first connector 246 to barrel 243, and (iv) a second one-way valve 249 (shown schematically in FIG. 2B ) fluidly connecting second connector 247 to barrel 243 and first one-way valve 248. Similarly, irrigation assembly 150 can include a pressure source 252, such as a syringe 252 having a barrel 253 and a plunger 254 slidable through the barrel 253, and an irrigation flow control assembly 255 fluidly coupled to the barrel 253. The irrigation flow control assembly 255 can include (i) a first connector 256, (ii) a second connector 257, (iii) a first one-way valve 258 (shown schematically in FIG. 2B ) fluidly connecting the first connector 256 to the barrel 253, and (iv) a second one-way valve 259 (shown schematically in FIG. 2B ) fluidly connecting the second connector 257 to the barrel 253 and the first one-way valve 258. In other embodiments, pressure sources 242, 252 can be other types of pumps or fluid pressure sources. In some embodiments, the plungers 244, 254 are coupled together via a handle 264 (FIG. 2A) such that the plungers 244, 254 are constrained to move together. In other embodiments, the syringes 242, 252 can be separated such that they are independently operable and / or can have different sizes.In some embodiments, the syringes 242, 252 can have a volume of approximately 60 cubic centimeters and can have a large-bore coupling of the type described, for example, in U.S. Patent Application No. 16 / 536,185, filed August 8, 2019, entitled "SYSTEM FOR TREATING EMBOLISM AND ASSOCIATED DEVICES AND METHODS," which is incorporated herein by reference in its entirety.

[0025] 1A-2B, a first connector 246 of pressure source assembly 140 can be connected to connector 126 of first tubing assembly 120 to fluidly connect inner lumen 111 of catheter assembly 110 to syringe 242, and a first connector 256 of irrigation assembly 150 can be connected to connector 136 of second tubing assembly 130 to fluidly connect outer lumen 117 of catheter assembly 110 to syringe 252. Referring to FIG. 2B, a second connector 247 of pressure source assembly 140 can be connected to waste reservoir 260 (e.g., a waste bag), and a second connector 257 of irrigation assembly 150 can be connected to irrigation reservoir 262 (e.g., a saline bag) configured to hold irrigation fluid. The irrigation fluid can be a sterile fluid having a relatively low viscosity, such as saline.

[0026] Arrow P on aspiration flow control assembly 245 of FIG. 引き抜き and P 押し下げ10A and 10B illustrate the operation of aspiration flow control assembly 245 when plunger 244 is withdrawn and depressed, respectively. First one-way valve 248 of aspiration flow control assembly 245 may be positioned to allow fluid flow through first connector 246 (e.g., from inner lumen 111) to barrel 243 of syringe 242 upon retraction (e.g., withdrawal) of plunger 244. Simultaneously, second one-way valve 249 of aspiration flow control assembly 245 prevents (e.g., blocks) backflow of fluid from waste reservoir 260 into barrel 243 of syringe 242. When plunger 244 is depressed (e.g., advanced), second one-way valve 249 may be positioned to allow fluid flow through second connector 247 (e.g., from barrel 243) to waste reservoir 260. At the same time, first one-way valve 248 prevents (eg, blocks) fluid flow from barrel 243 to inner lumen 111 .

[0027] Similarly, arrow I on irrigation flow control assembly 255 in FIG. 引き抜き and I 押し下げ 10A and 10B illustrate the operation of irrigation flow control assembly 255 when plunger 254 is withdrawn and depressed, respectively. Second one-way valve 259 of irrigation flow control assembly 255 can be positioned to allow fluid flow through second connector 257 (e.g., from irrigation reservoir 262) to barrel 253 of syringe 252 upon retraction (e.g., withdrawal) of plunger 254. Simultaneously, first one-way valve 258 of irrigation flow control assembly 255 prevents (e.g., blocks) backflow of fluid from first connector 256 into barrel 253 of syringe 252. When plunger 254 is depressed (e.g., advanced), first one-way valve 258 can be positioned to allow fluid flow through first connector 256 (e.g., from barrel 253) to outer lumen 117. At the same time, the second one-way valve 259 prevents (eg, blocks) the flow of fluid from the barrel 253 to the irrigation reservoir 262 .

[0028] 1A-2B , catheter assembly 110 can be introduced into a patient through a percutaneous opening (e.g., an abdominal opening, an intercostal opening) and advanced so that a distal portion of catheter assembly 110 is positioned within and / or near a cavity within the patient's body. Proximal portion 109 of dilator 108 can be detached from valve 102, and dilator 108 can be removed from catheter assembly 110 within the body. Handle 264 can then be withdrawn to withdraw plungers 244, 254 within barrels 243, 253, respectively. Retraction of plungers 244, 254 simultaneously (i) draws suction into inner lumen 111 of inner elongate member 112 to aspirate material from within the cavity, and (ii) fills (e.g., primes) syringe 252 with irrigation fluid from irrigation reservoir 262. Handle 264 can then be depressed to depress plungers 244, 254 within barrels 243, 253, respectively. Depressing plungers 244, 254 simultaneously (i) empties aspirated contents from the cavity from barrel 243 into waste reservoir 260, and (ii) forces irrigation fluid from barrel 253 into outer lumen 117 of outer elongate member 114 and through aperture 118 into the cavity, irrigating the cavity. Table 1 below illustrates the operation of system 100, and so forth.

[0029] [Table 1]

[0030] In some aspects of the present technology, actuation of syringe 242 can aspirate material from the cavity, while actuation of syringe 252 can irrigate the cavity to break up material therein and / or reduce its viscosity. Simultaneous actuation of syringes 242 and 252 can ensure constant volume maintenance within the cavity so that aspirated volume is replaced with irrigation volume. In additional aspects of the present technology, aspiration circuit 140 and irrigation circuit 150 are independently controlled by first and second one-way valves 248 and 249 of aspiration flow control assembly 245 and first and second one-way valves 258 and 259 of irrigation flow control assembly 255, respectively, connected to syringes 242 and 252, respectively. The flow control assemblies can ensure that each of inner lumen 111 and outer lumen 117 is a one-way path, so that irrigation aperture 118 does not become clogged, for example, when the side holes of a conventional drainage catheter are placed in a complex collection for aspiration. Furthermore, any contents within the aspiration lumen 111 are not reintroduced into the cavity during irrigation. That is, irrigation fluid is introduced through outer lumen 117, which is separate from aspiration lumen 111, so that irrigation does not reintroduce aspirated material into the cavity and so that aspiration does not clog the fluid path for the irrigation fluid.

[0031] Syringes 242, 252 can be repeatedly actuated to provide multiple aspiration / irrigation. In some embodiments, system 100 can be used in a single session to treat a cavity and completely or substantially completely remove its contents, so that the cavity is effectively drained in the initial treatment, eliminating the need to leave a drainage catheter behind. In other embodiments, after treating the cavity with system 100, a drainage catheter can be inserted into the cavity after the aspiration and irrigation treatment. System 100 may be left in the patient to function as a drainage system for a portion or the entire duration of drainage, and / or a separate drainage catheter (e.g., having a smaller size) may be inserted into the patient and system 100 removed for further drainage. That is, system 100 can be used for initial debridement, drainage, and flushing of the cavity contents, and then, upon removal of system 100, a standard, commercially available drain can be inserted in the same procedure to allow any remaining buildup to drain over the following days. In some aspects of the present technology, use of system 100 can eliminate the need for off-label mechanical devices and pharmacological agents for drainage, thus improving patient outcomes and reducing the duration of drainage.

[0032] In an additional aspect of the present technology, the catheter assembly 110 can be optimized to maximize drainage (e.g., aspiration) flow. For example, the catheter assembly 110 can be optimized taking into account Poiseuille's law.

[0033]

number

[0034] Therefore, the system 100 can be designed to maximize material flow by utilizing Poiseuille's law, as defined above. In some embodiments, the pressure differential is maximized by using a 60 cc syringe 242 capable of generating a vacuum of -25.5 inHg when fully evacuated. The radius of the inner elongate member 112 is maximized by utilizing a large-diameter side port tubing (e.g., in the first tubing assembly 120) and a large-diameter syringe 242, maintaining a single lumen with the same diameter from the distal tip to the syringe 242. Fluid viscosity can be reduced through the irrigation process, which can dilute the cavity contents with a low-viscosity irrigation fluid. The length of the system 100 can be minimized by maintaining the distance between the tip of the catheter assembly 110 and the vacuum source / syringe 242 as short as possible. In contrast, current drains can be connected to gravity collection bags, wall suction, or suction valves, which use excessive tubing length and reduce the efficiency of the drain.

[0035] In contrast to the present technology, typical dual-lumen catheters (either extruded or as part of a braided catheter) would face challenges in maintaining a reduced overall profile. Some common designs include a second lumen within or adjacent to the main aspiration lumen. These designs suffer from excessive outer diameter and a single lumen for irrigation that is in the same plane as the aspiration lumen. In some embodiments of the present technology, two coaxial lumens 111, 117 offer several advantages for this application: (i) a continuous, circular inner lumen 111 to maximize the entrance area to the aspiration lumen 111, and (ii) a concentric reservoir for circumferential (three-dimensional) irrigation via the outer lumen 117. In some embodiments of the present technology, circumferential irrigation is important not only to reduce the viscosity of the deposit but also to vigorously agitate the local area, potentially breaking up vesicles and displacing adherent material. The three-dimensional pattern of irrigation fluid dispensed through aperture 118 helps provide a more distributed, targeted irrigation that is not limited to a single plane as is the case with single lumen configurations. For example, a small single lumen for infusion (approximately 1 French to 4 French) can only achieve localized viscosity reduction without adequately disrupting the buildup.

[0036] In other embodiments, pressure source assembly 140 and / or irrigation assembly 150 may be configured to provide more control and / or operated in a different manner. For example, aspiration syringe 242 and irrigation syringe 252 may be operated independently or may have separate predetermined volumes for each stroke (e.g., by omitting handle 264). In some embodiments, fluid control device 124 may be closed during retraction of plunger 244 such that a vacuum is created (e.g., pre-charged) within barrel 243 of syringe 242. Fluid control device 124 may then be opened to apply a vacuum to inner lumen 111 and generate aspiration / suction pulses through inner lumen 111. Additionally, although first one-way valve 248 and second one-way valve 249 are shown to be within aspiration flow control assembly 245 and first one-way valve 258 and second one-way valve 259 are shown to be within irrigation flow control assembly 255, in other embodiments, any or all of one-way valves 248, 249, 258, 259 may be incorporated directly into catheter assembly 110, for example, to avoid any confusion or mixing of the aspiration and irrigation circuits.

[0037] 1A-1C, the system 100 can have a variety of other configurations. For example, (i) the dilator 108 can have a long or short tip for inserting the system 100 into a patient, (ii) the catheter assembly 110 can include a balloon tip for localized irrigation and retention within the lumen, and / or (iii) the distal portion of the catheter assembly 110 can have various curvatures (pigtail, J-hook, etc., as shown in FIGS. 7A-8B). Furthermore, in some embodiments, the outer lumen 117 can be omitted, and the catheter assembly 110 can include / define only the inner lumen 111. Such embodiments can provide a simplified design that maintains the benefits of large-bore aspiration / drainage without the ability to irrigate through a separate lumen. If desired, the large-bore lumen can also be used for irrigation. Additionally, in some embodiments, the outer elongate member 114 can define multiple irrigation lumens extending between the second hub 106 and, for example, a corresponding one or more of the apertures 118. The individual irrigation lumens can be disposed about the inner suction lumen 111 and can be formed via a multi-lumen extrusion process, a triaxial coiling / braiding process, and / or another suitable process. The individual irrigation lumens can be circular or have other cross-sectional shapes.

[0038] 1A-1C, in some embodiments, if irrigation is insufficient to disrupt the contents of the cavity (e.g., if the contents are too viscous or too large for aspiration after irrigation), a mechanical tool or element can be deployed into the cavity through the inner lumen 111 of the catheter assembly 110. In some embodiments, the mechanical element is similar to that used in thrombectomy procedures. The mechanical element can have a size and shape that can be controlled to form a desired geometry and manipulated within the cavity to assist with subsequent aspiration and drainage. FIGS. 3A-3C are enlarged side views of a mechanical disruptor assembly 370 in a compressed position, a partially extended position, and an extended position, respectively, configured to be advanced into the cavity through the catheter assembly 110 to mechanically disrupt material therein, for example, in accordance with embodiments of the present technology. 3A-3C, mechanical disruptor assembly 370 includes a disruptor element 371 that includes a plurality of interconnected struts and has a proximal portion 372 secured to a first elongated shaft 373 and a distal portion 374 secured to a second elongated shaft 375. Second elongated shaft 375 is slidably disposed within first elongated shaft 373. One or more of the struts can have a sharp cutting edge and / or one or more of the struts can have an atraumatic edge.

[0039] Disruptor element 371 may be made of nitinol braid, tubing, stainless steel, and / or any other biocompatible material. In some embodiments, mechanical disruptor assembly 370 may include some features that are generally similar to or identical to the features of the clot treatment devices described in detail in U.S. Patent Application No. 17 / 072,909, filed October 16, 2020, and entitled "SYSTEMS, DEVICES, AND METHODS FOR TREATING VASCULAR OCCLUSIONS," which is incorporated herein by reference in its entirety.

[0040] 3A-3D is a perspective view of a handle 380 of a mechanical disruptor assembly 370, in accordance with an embodiment of the present technology. With reference to FIGS. 3A-3D , a first elongate shaft 373 and a second elongate shaft 375 (e.g., proximal portions thereof) may be operably coupled to the handle 380. The handle 380 may include a first actuator 382 coupled to one of the first elongate shaft 373 or the second elongate shaft 375 and may be operable to translate the first and second elongate shafts 373, 375 relative to one another. For example, the first actuator 382 can be coupled to the second elongate shaft 375 such that (i) movement of the first actuator 382 in a proximal direction along the axis L retracts the second elongate shaft 375 proximally relative to the first elongate shaft 373, and (ii) movement of the first actuator 382 in a distal direction along the axis L advances the second elongate shaft 375 distally relative to the first elongate shaft 373. Movement of the first actuator 382 can move the disruptor element 371 between a compressed position, a partially extended position, and an extended position. For example, when the disruptor element is in a compressed position (FIG. 3A), first actuator 382 can be slid (e.g., proximally) to move second elongate shaft 375 proximally, moving distal portion 374 of disruptor element 371 proximally toward proximal portion 372 of disruptor element 371, radially expanding the disruptor element to a partially expanded position (FIG. 3B) and, upon further actuation, to an expanded position (FIG. 3C). In other embodiments, disruptor element 371 can be configured to passively expand (e.g., self-expand) within the cavity in addition to, or as an alternative to, actively expanding, e.g., via handle 380.

[0041] In other embodiments, the actuator 382 can have one or more locking positions within the handle 380 to determine the diameter of the disruptor element 371. Thus, the disruptor element can have a controllable diameter that can be gradually increased and manipulated to tear apart vesicles and / or other material within the body cavity, piece by piece, until the diameter of the disruptor element 371 reaches the wall of the body cavity. In some embodiments, the handle 380 further includes a second actuator 384 (e.g., a rotatable knob) operably coupled to the first elongate shaft 373 and / or the second elongate shaft 375. The second actuator 384 can be actuated (e.g., rotated) to rotate the disruptor element 371 to further break up material within the cavity, such as material adhering to the wall of the cavity. The mechanical disruptor assembly 370 can be laterally translated by a user (e.g., via movement of the handle 380) as needed, and can be delivered through the inner lumen 111 of the catheter assembly 110 with or without a guidewire.

[0042] 4 is a flow diagram of a process or method 480 for treating a body cavity in a patient using system 100 in accordance with an embodiment of the present technology. The body cavity may be an abdominal abscess, an abscess, a (e.g., complicated) pleural effusion, and / or another cavity containing unwanted material / contents. While certain features of method 480 are described in the context of the embodiment shown in FIGS. 1A-3D for illustrative purposes, one of ordinary skill in the art will readily understand that method 480 can be performed using other suitable systems and / or devices described herein. FIGS. 5A-5E are side cross-sectional views of a distal portion of catheter assembly 110 during different stages of method 480 in accordance with an embodiment of the present technology.

[0043] At block 481, method 480 may include percutaneously inserting catheter assembly 110 of system 100 into a patient such that a distal portion of catheter assembly 110 is positioned within the cavity to be treated. For example, FIG. 5A shows catheter assembly 110 inserted through a patient's skin 591 into a body cavity 592 having a substance or contents 593 positioned therein, such that distal opening 119 and aperture 118 are positioned within cavity 592. Substance 593 may include thick, viscous pus (e.g., purulent fluid), necrotic debris, blood clots, intestinal contents, vesicles, etc. Substance 593 may substantially fill cavity 592 as shown in FIG. 5A or may partially fill cavity 592. In some embodiments, catheter assembly 110 is inserted into the patient's abdomen or into an intercostal space proximal to cavity 592, for example, via a Seldinger technique, a trocar technique, and / or another catheter insertion technique. In some aspects of the present technology, the catheter assembly 110 can have a relatively short length M (FIG. 1A) because the catheter assembly 110 is designed to be inserted into the patient's skin 591 close to the cavity 592.

[0044] At block 482, the method 480 may include aspirating material from the cavity through the inner lumen 111 of the catheter assembly 110. For example, as described in detail above with reference to FIGS. 2A and 2B , the syringe 242 may be actuated (e.g., by withdrawing the plunger 244) to aspirate the inner lumen 111. During aspiration, the aspiration flow control assembly 245 is configured to allow fluid flow from the inner lumen 111 to the syringe 242 while simultaneously blocking fluid flow from the waste reservoir 260 to the syringe 242. FIG. 5B shows the catheter assembly 110 during aspiration as a suction force, indicated by arrow A, draws a portion 594 of material 593 proximally from the distal opening 119 into and through the inner lumen 111 of the inner elongate member 112. A portion 594 of the substance 593 can be drawn completely through the inner lumen 111, through the first tube assembly 120, through the aspiration flow control assembly 245, and into the barrel 243 of the syringe 242 where it is collected. In some aspects of the present technology, the substance 593 does not, or substantially does not, enter the outer lumen 117 of the outer elongate member 114 during aspiration because (i) the aperture 118 is in a different plane (e.g., an orthogonal plane) than the distal opening 119, and (ii) only the inner lumen 111 is aspirated such that clogging of the aperture 118 is inhibited or even prevented.

[0045] At block 483, the method 480 may include drawing irrigation fluid from the irrigation reservoir 262 through the outer lumen 117 of the catheter assembly 110 and through the aperture 118 into the lumen to irrigate the lumen. For example, as described in detail above with reference to FIGS. 2A and 2B , the syringe 252 may be primed with irrigation fluid by withdrawing the plunger 254 (e.g., while the plunger 244 of the syringe 242 is withdrawn to aspirate the inner lumen 111) and then depressed to force the irrigation fluid through the irrigation flow control assembly 255 and into the outer lumen 117. When the plunger 254 is depressed, the irrigation flow control assembly 255 allows irrigation fluid to flow into the outer lumen 117 while preventing irrigation fluid from flowing into the irrigation reservoir 262. 5C shows the catheter assembly 110 during irrigation, as indicated by arrow I, as irrigation fluid 595 is forced through the outer lumen 117 and through aperture 118 into cavity 592. In some aspects of the present technology, irrigation fluid 595 does not flow through inner lumen 111, such that any portion of material 593 remaining in inner lumen 111 after aspiration is not reintroduced into cavity 592. Irrigation fluid 595 can exit aperture 118 as a jet that mechanically disrupts (e.g., breaks down) material 593 within cavity 592. As described in detail above, the position, size, shape, and / or orientation of aperture 118 can be selected to provide a desired jet pattern for disrupting material 593. Irrigation fluid 595 can also have a lower viscosity than substance 593 in cavity 592, such that after irrigation, the mixture of irrigation fluid 595 and substance 593 in cavity 592 has a lower viscosity that can be more easily aspirated in a subsequent aspiration operation. For example, FIG. 5D shows catheter assembly 110 after irrigation, when the resulting mixture 596 of substance 593 and irrigation fluid 595 (FIG. 5C) has a lower viscosity than substance 593.

[0046] After irrigating at block 483, method 480 may return to block 482 to again aspirate the cavity, and then proceed again to block 483 to irrigate the cavity. Aspirating and irrigating may be performed as many times as necessary to sufficiently remove material from the cavity. Optionally, at block 484, method 480 may include mechanically disrupting (e.g., debriding) material within the cavity using a mechanical element, such as a disruptor element 371, inserted through inner lumen 111. FIG. 5E illustrates catheter assembly 110, for example, after inserting disruptor element 371 (shown schematically in FIG. 5E) through inner lumen 111 of inner elongate member 112 and into cavity 592, and after expanding disruptor element 371. Disruptor element 371 can be rotated (e.g., about first elongated shaft 373) within cavity 592 as indicated by arrow R and / or translated (e.g., proximally and / or distally) within cavity 592 to mechanically disrupt any material 593 remaining after aspiration and irrigation (blocks 482 and 483). In some embodiments, disruptor element 371 can be actuated to mechanically disrupt some or all of the material 593 that remains adhered to walls 597 of cavity 592 after aspiration and irrigation.

[0047] In other embodiments, the material within the cavity may be mechanically disrupted prior to aspiration and irrigation (blocks 482 and 483). That is, for example, disruptor element 371 may be inserted through inner lumen 111 into cavity 592 and rotated and / or translated within cavity 592 to first mechanically disrupt and / or break down material 593. In some aspects of the present technology, mechanically disrupting material 593 prior to aspiration and irrigation may make aspiration and irrigation more effective.

[0048] At block 485, the method 480 may include maintaining the catheter assembly 110 within the cavity to provide residual drainage of material from the cavity. The catheter assembly 110 may be maintained within the cavity for hours, days, or weeks to provide residual drainage.

[0049] At block 486, method 480 may include removing catheter assembly 110 from the patient after material has been sufficiently removed from the cavity. At block 487, method 480 may optionally include percutaneously inserting a separate drainage catheter into the cavity to provide (further) residual drainage. In some aspects of the present technology, the drainage catheter may have a smaller size (e.g., for improved patient comfort), may be configured for connection to an existing drainage waste bag, and / or may be of a type familiar to the operator (e.g., hospital staff). In such embodiments, system 100 may be used for initial debridement, drainage, and flushing of the cavity contents (blocks 482-484), and the separate drainage catheter may be a standard, commercially available drain inserted upon removal of system 100 within the same procedure to allow any remaining buildup to drain over the following days (block 486).

[0050] 6 is a side view of aspiration and irrigation system 600 ("system 600") in accordance with an additional embodiment of the present technology. System 600 may include some features that are at least generally similar or identical in structure and function to corresponding features of system 100, described in detail above with reference to FIGS. 1A-5E, and may operate in a manner that is generally similar or identical to system 100. For example, in the illustrated embodiment, system 600 includes (i) a valve 602 and (ii) a catheter assembly 610 fluidly connected to a tubing assembly 620 via a hub or side port 604.

[0051] In the illustrated embodiment, the catheter assembly 610 defines a single lumen that can be used to provide both suction and irrigation. That is, the catheter assembly 610 may include only a single elongate member 614 (e.g., sheath, catheter, shaft) extending distally from the valve 602 and the hub 604 and defining the lumen. The lumen may terminate in a distal opening 619 (e.g., aspiration and irrigation opening). The elongate member 614 may have a size of approximately 6 to 30 French, e.g., 6 French, 8 French, 12 French, 16 French, 20 French, 24 French, 26 French, or 30 French. The lumen of the elongate member 614 is fluidly connected to the tubing assembly 620 via (i) the valve 602 and (ii) the hub 604. Valve 602 may be an actuated access valve, as described in detail above with reference to FIGS. 1A-1C , configured to maintain fluid control during a body cavity treatment procedure by blocking or preventing proximal fluid flow through valve 602 when various components, such as, for example, a delivery sheath, a tensioning member, a guidewire, an interventional device, a mechanical disruptor assembly, or another aspiration catheter, are inserted through valve 602 and delivered to a treatment site within the body cavity through elongate member 614. In some embodiments, the lumen of elongate member 614 has a constant or substantially constant diameter extending from distal opening 619 to valve 602. That is, for example, elongate member 614 does not have a tapered or reduced diameter portion at its distal end portion or elsewhere along the length of elongate member 614. In some aspects of the present technology, this can maximize aspiration flow rate throughout the lumen of elongate member 614.

[0052] Tubing assembly 620 can fluidly connect the lumen of elongate member 614 to pressure source assembly 640 and / or irrigation assembly (not shown). For example, in the illustrated embodiment, tubing assembly 620 includes one or more tubing sections 622 (individually labeled as first tubing section 622a and second tubing section 622b), at least one fluid control device 624 (e.g., valve, stopcock), and at least one connector 626 (e.g., Toomey tip connector, quick release connector) for fluidly connecting tubing assembly 620 to pressure source assembly 640, irrigation assembly, and / or other suitable components.

[0053] Pressure source assembly 640 can include a pressure source 642, such as a syringe 642 having a barrel 643 and a plunger 644 slidable through the barrel 643, and an aspiration flow control assembly 645 fluidly coupled to the barrel 643 of the syringe 642. In some embodiments, the syringe 642 includes a locking mechanism 641 configured to selectively lock the plunger 644 relative to the barrel 643 (e.g., in a withdrawn position). Thus, the syringe 642 can be an automatic-locking syringe and can include some features that are at least broadly similar in structure and function to or identical in structure and function to the features of the automatic-locking syringes disclosed in U.S. Patent Application No. 17 / 396,426, filed August 6, 2021, and entitled "AUTOMATICALLY-LOCKING VACUUM SYRINGES, AND ASSOCIATED SYSTEMS AND METHODS," which is incorporated herein by reference in its entirety.

[0054] Aspiration flow control assembly 645 can include a body 650 having (i) a first connector 646 (partially obscured in FIG. 6 ) configured to be coupled to connector 626 of tubing assembly 620, (ii) a second connector 647 configured to be coupled to (e.g., at the tip of) syringe 642, and (iii) a third connector 648 configured to be coupled to a waste reservoir 660, which is fluidly connected to a waste collection bag 662 or other fluid reservoir in waste reservoir 660, more specifically, to at least one tube 661 of waste reservoir 660. Body 650 can define one or more lumens fluidly connecting first through third connectors 646 through 648. In the illustrated embodiment, aspiration flow control assembly 645 further includes a first one-way valve 651 (shown schematically in FIG. 6 ) in the fluid path between first connector 646 and second connector 647, and a second one-way valve 652 (shown schematically in FIG. 6 ) in the fluid path between second connector 647 and third connector 648. First one-way valve 651 is positioned to allow fluid flow from the lumen of tubing assembly 620 and elongate member 614 through aspiration flow control assembly 645 to barrel 643 of syringe 642 (e.g., from first connector 646 to second connector 647 and through), while preventing fluid flow from syringe 642 to tubing assembly 620 (e.g., from second connector 647 to first connector 646 and through). The second one-way valve 652 is positioned to allow fluid flow from the barrel 643 of the syringe 642 through the aspiration flow control assembly 645 to the waste reservoir 660 (e.g., from the second connector 647 to the third connector 648 and through it), while preventing fluid flow from the waste reservoir 660 to the syringe 642 (e.g., from the third connector 648 to the second connector 647 and through it).

[0055] Thus, withdrawal of plunger 644 through barrel 643 creates a negative pressure within barrel 643, which draws fluid through distal opening 619 and the lumen of elongate member 614, through tubing assembly 620, through aspiration flow control assembly 645 (e.g., through first connector 646, first one-way valve 651, and second connector 647), and into barrel 643 of syringe 642. During withdrawal of plunger 644, second one-way valve 652 prevents (e.g., blocks) the backflow of fluid from waste reservoir 660 into barrel 643 of syringe 642. Conversely, depression of plunger 644 through barrel 643 creates a positive pressure within barrel 643, which forces fluid from barrel 643 through aspiration flow control assembly 645 (e.g., through second connector 647, second one-way valve 652, and third connector 648) and into waste reservoir 660 (e.g., through tubing 661 and into collection bag 662). During depression of plunger 644, first one-way valve 651 prevents (e.g., blocks) the flow of fluid from barrel 643 into tubing assembly 620 and the lumen of elongate member 614.

[0056] In some embodiments, the pressure source assembly 640 can be disconnected from the connector 626 of the tubing assembly 620 (e.g., with the fluid control device 624 in the closed position), and the irrigation assembly can be coupled to the connector 626 to fluidly couple the irrigation assembly to the lumen of the elongate member 614. In some embodiments, the irrigation assembly can include a syringe or other pressure source and a reservoir of irrigation fluid (e.g., as described in detail above with reference to FIGS. 2A and 2B ). The pressure source can be actuated (e.g., by depressing the plunger of the syringe) to force irrigation fluid through the tubing assembly 620, through the lumen of the elongate member 614, and out the distal opening 619 of the elongate member 614. In some embodiments, the irrigation assembly can alternatively or additionally be coupled to a port 625 of the fluid control device 624 that provides a fluid connection to the tubing assembly 620 and the lumen of the elongate member 614. In such an embodiment, the pressure source of the irrigation assembly can be activated to pump irrigation fluid through the port 625, through the tube assembly 620, through the lumen of the elongate member 614, and out the distal opening 619 of the elongate member 614.

[0057] In operation, catheter assembly 610 is introduced into a patient through a percutaneous opening (e.g., an abdominal opening, an intercostal space opening) and advanced so that a distal portion of catheter assembly 610 (e.g., distal opening 619 of elongate member 614) is positioned in and / or near a cavity within the patient's body. Pressure source assembly 640 can be coupled to tubing assembly 620, and fluid control device 624 can be opened to fluidly connect pressure source assembly 620 to the lumen of elongate member 614. Plunger 644 of syringe 642 can then be withdrawn to draw fluid from the lumen of elongate member 614 and aspirate material from within the cavity into barrel 643. Plunger 644 can then be depressed to expel material from barrel 643 and into collection bag 662. In some embodiments, plunger 644 can be repeatedly withdrawn and then depressed (e.g., pumped) to aspirate the cavity and expel the aspirated material into collection bag 662. In some aspects of the present technology, collection bag 662 provides a sealed container for aspirated material, allowing for a cleaner procedure by reducing contamination, odors, exposure to infectious materials, etc. In some embodiments, fluid control device 624 can be closed during retraction of plunger 644 such that a vacuum is created (e.g., pre-charged) within barrel 643 of syringe 642. Fluid control device 624 can then be opened to apply a vacuum to the lumen of elongate member 614, generating a suction / aspiration pulse through the lumen to aspirate material within the lumen.

[0058] At any point during the procedure, fluid control device 624 can be closed and pressure source assembly 640 can be disconnected from tubing assembly 620. The irrigation assembly can then be coupled to tubing assembly 620, fluid control device 624 can be opened, and the irrigation assembly can be activated to pump irrigation fluid into the lumen of elongate member 614 and out of distal opening 619 into the patient's cavity. Multiple irrigation passes / cycles can be performed. Alternatively or additionally, pressure source assembly 640 can remain coupled to tubing assembly 620, and the irrigation assembly can be coupled to port 625 to provide irrigation through the lumen of elongate member 614. Irrigation and aspiration can be provided in any order and can be repeated as needed: aspiration first, then irrigation; irrigation first, then aspiration; one or more cycles of aspiration, followed by one or more cycles of irrigation; one or more cycles of irrigation, followed by one or more cycles of aspiration, etc.

[0059] In some embodiments, the distal portion of the elongate member 614 can be curved to facilitate placement and positioning within a patient's lumen. FIG. 7A is a side view of a catheter assembly 610, for example, in accordance with an additional embodiment of the present technology. In the illustrated embodiment, the elongate member 614 has a distal curved portion 718 (e.g., a distal curved end portion, a distal curved region, a distal curved end portion, a curved distal tip, etc.) configured (e.g., heat-set) to bend away from the longitudinal axis Z of the catheter assembly 610. In the illustrated embodiment, the distal curved portion 718 has a generally curved shape and can bend away from the longitudinal axis Z at a bend angle A of about 30-90 degrees (e.g., about 80 degrees), about 165-195 degrees (e.g., about 180 degrees), or greater than 195 degrees (e.g., about 250-290 degrees, about 270 degrees). Thus, the distal curved portion 718 can have a bend ranging from a full pigtail to a sub-angle. The curve of the distal curved portion 718 offsets the distal opening 619 from the longitudinal axis Z. During a procedure to treat a patient's cavity, the elongate member 614 can be twisted (e.g., rotated) to control the position of the distal opening 619 within the cavity to provide directional suction and / or irrigation.

[0060] In some embodiments, the distal curved portion 718 can be moved between (i) a relaxed position, in which the distal curved portion 718 has the curved shape illustrated in FIG. 7A , and (ii) a constrained position, in which the distal curved portion 718 is more closely aligned with the longitudinal axis Z (e.g., with a reduced bend angle A). For example, FIG. 7B is a side view of a catheter assembly 610 with a dilator 708 inserted through the valve 602 and through the lumen of the elongate member 614, in accordance with an embodiment of the present technology. In the illustrated embodiment, the dilator 708 includes a proximal coupling portion 709 secured to and / or mated to a corresponding portion of the valve 602. The dilator 708 extends entirely through the lumen of the elongate member 614 and out the distal opening 619. Upon insertion through the lumen of the elongate member 614, the dilator 708 can constrain the distal curved portion 718, as shown in FIG. 7B, to reduce bend angle A (FIG. 7A) and align the distal curved portion 718 more closely with the longitudinal axis Z (FIG. 7A). Alternatively, a guidewire (not shown) can constrain the distal curved portion 718, to reduce bend angle A (FIG. 7A) and align the distal curved portion 718 more closely with the longitudinal axis Z (FIG. 7A). For example, in some embodiments, the dilator 708 and / or valve 702 can be of the type disclosed in U.S. Patent Application No. 18 / 156,944, filed January 19, 2023, and entitled "CLOT TREATMENT SYSTEMS WITH DILATOR LOCKING MECHANISMS, AND ASSOCIATED DEVICES AND METHODS," which is incorporated herein by reference in its entirety.

[0061] 7A and 7B, the distal curved portion 718 can be formed using a heat setting process or other suitable process to have the curved shape illustrated in FIG. 7A or another curved shape (e.g., a full pigtail shape, a tiger curve shape, a jack curve shape, an amplatz left shape, an LCB shape, an RCB shape, a Judkins left shape, a Judkins right shape, a multipurpose A2 shape, an IM shape, a 3D LIMA shape, an IM VB-1 shape, etc.). For example, as is known in the art of heat setting shape memory structures, a fixture, mandrel, or mold may be used to hold the distal curved portion 718 in its desired shape, and the distal curved portion 718 can then be subjected to a suitable heat treatment such that the shape memory material (e.g., metal, nitinol, steel) structure used to form the elongate member 614 (e.g., braid, coil, etc.) assumes the outer contour of the mandrel or mold or is otherwise shape-set. The heat setting process can be carried out in an oven or fluidized bed, as is well known. Thus, the heat setting process can impart a desired shape, geometry, bend, and / or curvature in one or more superelastic and / or shape memory materials used to form elongate member 614. Thus, distal curved portion 718 can be radially constrained without plastic deformation as shown in FIG. 7B and will self-expand to the position illustrated in FIG. 7A upon release of the radial constraint. In some embodiments, distal curved portion 718 and / or elongate member 614 can include some features that are at least broadly similar in structure and function to or identical in structure and function to features of catheters disclosed in U.S. Patent Application Publication No. 17 / 529,018, filed November 17, 2021, and entitled "CATHETERS HAVING SHAPED DISTAL PORTIONS, AND ASSOCIATED SYSTEMS AND METHODS," which is incorporated herein by reference in its entirety.

[0062] In some embodiments, the elongate member 614 can have one or more apertures formed in and / or proximal to the distal curved portion 718. Figures 8A and 8B are enlarged side views of a distal portion of the elongate member 614 of the catheter assembly 610, for example, in accordance with an embodiment of the present technology. The elongate member 614 has a first size (e.g., 24 French) in Figure 8A and a second size (e.g., 16 French) smaller than the first size in Figure 8B. With reference to Figures 8A and 8B, the elongate member 614 includes / defines one or more (e.g., multiple) apertures 890 (e.g., holes, side holes) fluidly coupled to the lumen of the elongate member 614. In the illustrated embodiment, the apertures 890 are aligned circumferentially with respect to the longitudinal axis Z (Figure 6) and can be spaced apart from one another with respect to the longitudinal axis Z proximal to the distal curved portion 718. In other embodiments, some or all of the apertures 890 may be circumferentially distributed, spaced apart in different ways, and formed in / at other portions of the distal curved portion 718 and / or elongate member 614. With reference to FIGS. 6, 8A, and 8B, when the lumen of the elongate member 614 is aspirated via the suction source assembly 620, suction pressure may be applied through the apertures 890 and / or through the distal openings 619. Similarly, when the lumen of the elongate member 614 is irrigated via the irrigation assembly, irrigation fluid may be injected through the apertures 890 and / or through the distal openings 619. In some aspects of the present technology, the apertures 890 may reduce the likelihood of clogging of the elongate member 614 and reduce suction forces from each of the apertures 890 and / or the distal openings 619.

[0063] 8A and 8B , in some embodiments, the catheter assembly 610 can include a cover or other feature (not shown) that can be manipulated during a procedure to cover one or more of the apertures 890. For example, another elongate member, sheath, or the like can be advanced through the lumen of the elongate member 614 and / or over the exterior surface of the elongate member 614 to cover the apertures 890. Covering the apertures 890 can increase the resulting suction force at the distal opening 619. The cover can include one or more apertures that align with the apertures 890 of the elongate member 614 to selectively control through which apertures 890 the resulting suction force should be applied. Similarly, some or all of the cover apertures (not shown) can be circumferentially distributed and / or spaced differently on the cover. Additionally, another elongate shaft, member, sheath, etc. can be advanced distally through the lumen of the elongate member 614 and / or over the exterior surface of the elongate member 614 to bring the distal curved portion 718 into closer alignment with the longitudinal axis Z ( FIG. 7A ). The cover or elongate shaft can be operably coupled to a handle (not shown) having an actuator coupled to the elongate shaft. The actuator can be manipulated to move the elongate shaft relative to the longitudinal axis Z.

[0064] Several aspects of the present technology are described in the following examples. 1. A system for aspirating and irrigating a body cavity, comprising: 1. A catheter assembly comprising: an outer elongate member defining an outer lumen; a catheter assembly including: an inner elongate member extending at least partially through the outer elongate member and defining an inner lumen having a distal opening, wherein a distal portion of the outer elongate member is fluid-sealed to the inner elongate member, the outer elongate member including an aperture located proximally of the distal portion; a suction source fluidly connected to the inner lumen and configured to draw suction on the inner lumen; an irrigation source fluidly connected to the outer lumen and configured to flow irrigation fluid through the outer lumen and out the aperture. 2. The system of example 1, wherein the inner elongate member is coaxial with the outer elongate member. 3. The system of Example 1 or Example 2, wherein the suction source is a first syringe and the irrigation source is a second syringe. 4. The system of any one of Examples 1-3, wherein the aperture is one of a plurality of apertures positioned circumferentially around the outer elongate member. 5. Further including an aspiration flow control assembly fluidly connected between the aspiration source and the inner lumen, the aspiration flow control further fluidly connected to the waste reservoir, the aspiration flow control assembly comprising: when the suction source is activated in a first manner, allowing fluid flow from the inner lumen to the suction source while blocking fluid flow from the waste reservoir to the suction source; The system of any one of Examples 1 to 4, configured to allow fluid flow from the suction source to the waste reservoir while blocking fluid flow from the suction source to the inner lumen when the suction source is activated in a second manner different from the first manner. 6. The system of example 5, wherein the suction source is a syringe having a plunger, the first mode being a withdrawal of the plunger, and the second mode being a depression of the plunger. 7. Further including an irrigation flow control assembly fluidly coupled between the irrigation source and the outer lumen, the irrigation flow control assembly further fluidly coupled to an irrigation reservoir configured to hold irrigation fluid, the irrigation flow control assembly comprising: when the irrigation source is activated in a first manner, allowing irrigation fluid flow from the irrigation reservoir to the irrigation source while blocking fluid flow from the outer lumen to the irrigation source; A system described in any one of Examples 1 to 6, configured to allow irrigation fluid to flow from the irrigation source into the outer lumen while blocking the flow of irrigation fluid from the irrigation source into the irrigation reservoir when the irrigation source is operated in a second mode different from the first mode. 8. The system of Example 7, wherein the irrigation source is a syringe having a plunger, the first mode being a withdrawal of the plunger, and the second mode being a depression of the plunger. 9. an aspiration flow control assembly fluidly coupled between the aspiration source and the inner lumen, the aspiration flow control assembly further fluidly coupled to the waste reservoir, the aspiration flow control assembly comprising: when the suction source is activated in a first manner, allowing fluid flow from the inner lumen to the suction source while blocking fluid flow from the waste reservoir to the suction source; an aspiration flow control assembly configured to allow fluid flow from the suction source to the waste reservoir while blocking fluid flow from the suction source to the inner lumen when the suction source is activated in a second manner different from the first manner; an irrigation flow control assembly fluidly coupled between the irrigation source and the outer lumen, the irrigation flow control assembly further fluidly coupled to an irrigation reservoir configured to hold irrigation fluid, the irrigation flow control assembly comprising: when the irrigation source is activated in a third mode, allowing irrigation fluid flow from the irrigation reservoir to the irrigation source while blocking fluid flow from the outer lumen to the irrigation source; A system described in any one of Examples 1 to 8, further comprising an irrigation flow control assembly configured to allow irrigation fluid to flow from the irrigation source into the outer lumen while blocking the flow of irrigation fluid from the irrigation source into the irrigation reservoir when the irrigation source is operated in a fourth mode different from the third mode. 10. The system of Example 9, wherein the suction source is a first syringe having a first plunger, the first mode is withdrawing the first plunger, the second mode is depressing the second plunger, and the irrigation source is a second syringe having a second plunger, the third mode is withdrawing the second plunger, and the fourth mode is depressing the second plunger. 11. The system of example 10, wherein the first plunger and the second plunger are mechanically coupled and configured to move together during withdrawal and depression. 12. an aspiration flow control assembly fluidly coupled between the aspiration source and the inner lumen, the aspiration flow control assembly comprising: a first connector configured to be fluidly coupled to the inner lumen; a second connector configured to be fluidly connected to a waste reservoir; a first one-way valve positioned between the first connector and the suction source, the first one-way valve positioned to (a) allow fluid flow from the inner lumen through the first connector to the suction source, and (b) prevent fluid flow from the suction source to the inner lumen through the first connector; The system of any one of Examples 1 to 11, further comprising a suction flow control assembly including: a second one-way valve positioned between the second connector and the suction source, the second one-way valve positioned to (a) allow fluid flow from the suction source to the waste reservoir through the second connector, and (b) prevent fluid flow from the waste reservoir to the suction source through the second connector. 13. the suction source includes a syringe having a plunger; Retraction of the plunger is configured to aspirate material from the cavity through the inner lumen; During plunger retraction, a first one-way valve is positioned to allow flow of material through the first connector and into the syringe, and a second one-way valve is positioned to prevent flow from the waste reservoir to the syringe; Depression of the plunger is configured to flush the aspirated material from the syringe into a waste reservoir; 13. The system of Example 12, wherein during depression of the plunger, a first one-way valve is positioned to prevent flow of aspirated material into the inner lumen through the first connector, and a second one-way valve is positioned to allow flow of aspirated material from the syringe through the second connector into the waste reservoir. 14. an irrigation flow control assembly fluidly connected between the irrigation source and the outer lumen, the aspiration flow control assembly comprising: a first connector configured to be fluidly connected to the outer lumen; a second connector configured to be fluidly connected to the irrigation reservoir; a first one-way valve positioned between the first connector and the irrigation source, the first one-way valve positioned to (a) allow fluid flow from the irrigation source to the outer lumen through the first connector and (b) prevent fluid flow from the inner lumen to the irrigation source through the first connector; The system of any one of Examples 1 to 13, further comprising an irrigation flow control assembly including a second one-way valve positioned between the second connector and the irrigation source, the second one-way valve positioned to (a) allow fluid flow from the irrigation reservoir to the irrigation source through the second connector, and (b) prevent fluid flow from the irrigation source to the irrigation reservoir through the second connector. 15. the irrigation source includes a syringe having a plunger; Retraction of the plunger is configured to at least partially fill the syringe with irrigation fluid from the irrigation reservoir; a first one-way valve positioned to prevent flow through the first connector into the syringe during plunger retraction, and a second one-way valve positioned to allow flow of irrigation fluid from the irrigation reservoir to the syringe; Depression of the plunger is configured to cause irrigation fluid to flow from the syringe into the outer lumen; The system described in Example 14, wherein during depression of the plunger, a first one-way valve is positioned to allow flow of irrigation fluid into the outer lumen through the first connector, and a second one-way valve is positioned to prevent flow of irrigation fluid from the syringe into the irrigation reservoir through the second connector. 16. an aspiration flow control assembly fluidly coupled between the aspiration source and the inner lumen, the aspiration flow control assembly comprising: a first connector configured to be fluidly coupled to the inner lumen; a second connector configured to be fluidly connected to a waste reservoir; a first one-way valve positioned between the first connector and the suction source, the first one-way valve positioned to (a) allow fluid flow from the inner lumen through the first connector to the suction source, and (b) prevent fluid flow from the suction source to the inner lumen through the first connector; a suction flow control assembly including: a second one-way valve positioned between the second connector and the suction source, the second one-way valve positioned to (a) allow fluid flow from the suction source to the waste reservoir through the second connector, and (b) prevent fluid flow from the waste reservoir to the suction source through the second connector; an irrigation flow control assembly fluidly connected between the irrigation source and the outer lumen, the aspiration flow control assembly comprising: a third connector configured to be fluidly connected to the outer lumen; a fourth connector configured to be fluidly connected to the irrigation reservoir; a third one-way valve positioned between the third connector and the irrigation source, the third one-way valve positioned to (a) allow fluid flow from the irrigation source to the outer lumen through the third connector and (b) prevent fluid flow from the inner lumen to the irrigation source through the third connector; The system of any one of Examples 1 to 15, further comprising an irrigation flow control assembly including a fourth one-way valve positioned between the fourth connector and the irrigation source, the fourth one-way valve being positioned to (a) allow fluid flow from the irrigation reservoir to the irrigation source through the fourth connector, and (b) prevent fluid flow from the irrigation source to the irrigation reservoir through the fourth connector. 17. the suction source is a first syringe having a first plunger; Retraction of the first plunger is configured to aspirate material from the cavity through the inner lumen; During withdrawal of the first plunger, a first one-way valve is positioned to allow flow of material through the first connector into the first syringe, and a second one-way valve is positioned to prevent flow from the waste reservoir to the first syringe; Depression of the first plunger is configured to cause the aspirated material to flow from the first syringe to the waste reservoir; During depression of the first plunger, a first one-way valve is positioned to prevent flow of aspirated material into the inner lumen through the first connector, and a second one-way valve is positioned to allow flow of aspirated material from the first syringe through the second connector and into the waste reservoir; the irrigation source is a second syringe having a second plunger; retraction of the second plunger is configured to at least partially fill the second syringe with irrigation fluid from the irrigation reservoir; a third one-way valve positioned to block flow through the third connector into the second syringe during retraction of the second plunger, and a fourth one-way valve positioned to allow flow of irrigation fluid from the irrigation reservoir to the second syringe; Depression of the second plunger is configured to cause irrigation fluid to flow from the second syringe into the outer lumen; The system described in Example 16, wherein during depression of the second plunger, the third one-way valve is positioned to allow flow of irrigation fluid into the outer lumen through the third connector, and the fourth one-way valve is positioned to prevent flow of irrigation fluid from the second syringe into the irrigation reservoir through the fourth connector. 18. The system of example 17, wherein the first plunger and the second plunger are mechanically coupled and configured to move together. 19. The system of any one of Examples 1-18, wherein the inner elongate member is a reinforced catheter and the outer elongate member is a tube formed from a plastic material. 20. A method of treating material in a body cavity of a patient, comprising: percutaneously inserting a catheter assembly into a patient such that a distal portion of the catheter assembly is intraluminal; Aspirating material from the cavity through the inner lumen of the catheter assembly; and flowing irrigation fluid through an outer lumen of the catheter assembly and out an outer aperture of the catheter assembly into the cavity to irrigate the cavity, wherein the outer lumen is coaxial with the inner lumen. twenty one. inserting a mechanical disruptor element through the inner lumen; expanding a mechanical disruptor element within the cavity; 21. The method of example 20, further comprising engaging a mechanical disruptor element with the material within the cavity to mechanically disrupt the material. 22. The method of example 20 or example 21, wherein aspirating the material from the cavity comprises actuating a syringe fluidly connected to the inner lumen. 23. The method of any one of Examples 20-22, wherein flowing irrigation fluid through the outer lumen comprises actuating a syringe fluidly connected to the outer lumen. 24. The method of any one of Examples 20-23, wherein aspirating the substance from the cavity comprises withdrawing the plunger of an aspirating syringe fluidly connected to the inner lumen, and flowing irrigation fluid through the outer lumen comprises depressing the plunger of an irrigation syringe fluidly connected to the outer lumen. 25. The method, withdrawing the plunger of the irrigation syringe to draw irrigation fluid into the irrigation syringe; 25. The method of example 24, further comprising depressing the plunger of the aspirating syringe to expel the aspirated material from the aspirating syringe. 26. The method, simultaneously withdrawing the plunger of the aspirating syringe to aspirate material from the cavity and withdrawing the plunger of the irrigating syringe to draw irrigation fluid into the irrigating syringe; 26. The method of example 25, further comprising simultaneously depressing the plunger of the aspirating syringe to expel the aspirated material from the aspirating syringe and depressing the plunger of the irrigation syringe to flow irrigation fluid into the cavity to irrigate the cavity. 27. The method of example 26, wherein the plunger of the aspiration syringe and the plunger of the irrigation syringe are mechanically coupled to move together. 28. A system for aspirating and irrigating a body cavity, comprising: 1. A catheter assembly comprising: an outer elongate member defining an outer lumen; a catheter assembly including: an inner elongate member extending at least partially through the outer elongate member and defining an inner lumen having a distal opening, wherein a distal portion of the outer elongate member is fluid-sealed to the inner elongate member, the outer elongate member including an aperture located proximally of the distal portion; an aspiration syringe fluidly connected to the inner lumen and configured to aspirate the inner lumen; an irrigation syringe fluidly connected to the outer lumen and configured to flow irrigation fluid through the outer lumen and out the aperture. 29. The system described in Example 28, wherein the aspiration syringe and the irrigation syringe are mechanically coupled to operate synchronously. 30. A method of using the system of any one of Examples 1-19, 28, or 29 to treat material in a body cavity of a patient. 31. An aspiration flow control assembly for use within the aspiration and irrigation system of any one of Examples 5, 6, 9-13, or 16-18. 32. An irrigation flow control assembly for use in the aspiration and irrigation system of any one of Examples 7-11 or 14-18. 33. A combined aspiration flow control assembly and irrigation flow control assembly for use in the aspiration and irrigation system of any one of Examples 9-11 or 16-18.

[0065] The above detailed description of embodiments of the present technology is not intended to be exhaustive or to limit the present technology to the precise form disclosed above. While specific embodiments and examples of the present technology have been described above for illustrative purposes, those skilled in the art will recognize that various equivalent modifications are possible within the scope of the present technology. For example, while steps are presented in a given order, alternative embodiments may perform steps in a different order. Various embodiments described herein may also be combined to provide further embodiments.

[0066] From the foregoing, it will be understood that, although specific embodiments of the present technology have been described herein for illustrative purposes, well-known structures and functions have not been shown or described in detail to avoid unnecessarily obscuring the description of the embodiments of the present technology. Where permitted by context, singular or plural terms may also include the plural or singular terms, respectively.

[0067] Furthermore, unless the word "or" is expressly limited in reference to a list of two or more items to mean only a single item exclusively from the other items, the use of "or" in such a list should be interpreted as including (a) any single item in the list, (b) all of the items in the list, or (c) any combination of the items in the list. Additionally, the term "comprising" is used throughout to mean the inclusion of at least the recited features, but not the exclusion of any more of the same features and / or other features of additional types. While specific embodiments have been described herein for illustrative purposes, it will also be understood that various modifications can be made without departing from the present technology. Furthermore, while advantages associated with some embodiments of the present technology have been described in the context of these embodiments, other embodiments may also exhibit such advantages, and not all embodiments necessarily exhibit such advantages to fall within the scope of the present technology. Thus, the present disclosure and related technology may encompass other embodiments not explicitly shown or described herein.

Claims

1. 1. A system for aspirating and irrigating a body cavity, comprising:

1. A catheter assembly comprising: an outer elongate member defining an outer lumen; a catheter assembly including an inner elongate member extending at least partially through the outer elongate member and defining an inner lumen having a distal opening, a distal portion of the outer elongate member being fluid-sealed to the inner elongate member, the outer elongate member including an aperture located proximally of the distal portion; a suction source fluidly connected to the inner lumen and configured to draw suction on the inner lumen; an irrigation source fluidly connected to the outer lumen and configured to flow irrigation fluid through the outer lumen and out the aperture.

2. The system of claim 1 , wherein the inner elongate member is coaxial with the outer elongate member.

3. The system of claim 1 , wherein the suction source is a first syringe and the irrigation source is a second syringe.

4. The system of claim 1 , wherein the aperture is one of a plurality of apertures positioned circumferentially around the outer elongate member.

5. and an aspiration flow control assembly fluidly coupled between the aspiration source and the inner lumen, the aspiration flow control further fluidly coupled to a waste reservoir, the aspiration flow control assembly comprising: when the suction source is activated in a first manner, allowing fluid flow from the inner lumen to the suction source while blocking fluid flow from the waste reservoir to the suction source; 2. The system of claim 1, wherein the system is configured to allow fluid flow from the suction source to the waste reservoir while blocking fluid flow from the suction source to the inner lumen when the suction source is operated in a second mode different from the first mode.

6. 6. The system of claim 5, wherein the suction source is a syringe having a plunger, the first modality being withdrawal of the plunger, and the second modality being depression of the plunger.

7. and an irrigation flow control assembly fluidly coupled between the irrigation source and the outer lumen, the irrigation flow control assembly further fluidly coupled to an irrigation reservoir configured to hold an irrigation fluid, the irrigation flow control assembly comprising: when the irrigation source is activated in a first manner, allowing the irrigation fluid to flow from the irrigation reservoir to the irrigation source while blocking fluid flow from the outer lumen to the irrigation source; 2. The system of claim 1, wherein the system is configured to allow the irrigation fluid to flow from the irrigation source into the outer lumen while blocking the flow of the irrigation fluid from the irrigation source into the irrigation reservoir when the irrigation source is operated in a second mode different from the first mode.

8. The system of claim 7 , wherein the irrigation source is a syringe having a plunger, the first modality being withdrawal of the plunger, and the second modality being depression of the plunger.

9. an aspiration flow control assembly fluidly coupled between the aspiration source and the inner lumen, the aspiration flow control assembly further fluidly coupled to a waste reservoir, the aspiration flow control assembly comprising: when the suction source is activated in a first manner, allowing fluid flow from the inner lumen to the suction source while blocking fluid flow from the waste reservoir to the suction source; an aspiration flow control assembly configured to allow fluid flow from the suction source to the waste reservoir while blocking fluid flow from the suction source to the inner lumen when the suction source is activated in a second manner different from the first manner; an irrigation flow control assembly fluidly coupled between the irrigation source and the outer lumen, the irrigation flow control assembly further fluidly coupled to an irrigation reservoir configured to hold irrigation fluid, the irrigation flow control assembly comprising: when the irrigation source is activated in a third manner, allowing the irrigation fluid to flow from the irrigation reservoir to the irrigation source while blocking fluid flow from the outer lumen to the irrigation source; 2. The system of claim 1, further comprising an irrigation flow control assembly configured to allow the irrigation fluid to flow from the irrigation source into the outer lumen while blocking the flow of the irrigation fluid from the irrigation source into the irrigation reservoir when the irrigation source is operated in a fourth mode different from the third mode.

10. 10. The system of claim 9, wherein the suction source is a first syringe having a first plunger, the first modality being withdrawal of the first plunger, the second modality being depression of the second plunger, and the irrigation source is a second syringe having a second plunger, the third modality being withdrawal of the second plunger, and the fourth modality being depression of the second plunger.

11. The system of claim 10 , wherein the first plunger and the second plunger are mechanically coupled and configured to move together during withdrawal and depression.

12. an aspiration flow control assembly fluidly coupled between the aspiration source and the inner lumen, the aspiration flow control assembly comprising: a first connector configured to be fluidly connected to the inner lumen; a second connector configured to be fluidly connected to the waste reservoir; a first one-way valve positioned between the first connector and the suction source, the first one-way valve positioned to (a) allow fluid flow from the inner lumen through the first connector to the suction source, and (b) prevent fluid flow from the suction source to the inner lumen through the first connector; 10. The system of claim 1, further comprising a suction flow control assembly including: a second one-way valve positioned between the second connector and the suction source, the second one-way valve positioned to (a) allow fluid flow from the suction source to the waste reservoir through the second connector; and (b) prevent fluid flow from the waste reservoir to the suction source through the second connector.

13. the suction source includes a syringe having a plunger; withdrawal of the plunger is configured to aspirate material from the cavity through the inner lumen; During withdrawal of the plunger, the first one-way valve is positioned to allow flow of the substance through the first connector and into the syringe, and the second one-way valve is positioned to prevent flow from the waste reservoir to the syringe; Depression of the plunger is configured to flush the aspirated material from the syringe into the waste reservoir; 13. The system of claim 12, wherein during depression of the plunger, the first one-way valve is positioned to prevent flow of the aspirated material through the first connector and into the inner lumen, and the second one-way valve is positioned to allow flow of the aspirated material from the syringe through the second connector and into the waste reservoir.

14. an irrigation flow control assembly fluidly coupled between the irrigation source and the outer lumen, the aspiration flow control assembly comprising: a first connector configured to be fluidly connected to the outer lumen; a second connector configured to be fluidly connected to the irrigation reservoir; a first one-way valve positioned between the first connector and the irrigation source, the first one-way valve positioned to (a) allow fluid flow from the irrigation source through the first connector to the outer lumen, and (b) prevent fluid flow from the inner lumen through the first connector to the irrigation source; 2. The system of claim 1, further comprising an irrigation flow control assembly including: a second one-way valve positioned between the second connector and the irrigation source, the second one-way valve positioned to (a) allow fluid flow from the irrigation reservoir to the irrigation source through the second connector; and (b) prevent fluid flow from the irrigation source to the irrigation reservoir through the second connector.

15. the irrigation source includes a syringe having a plunger; retraction of the plunger is configured to at least partially fill the syringe with irrigation fluid from the irrigation reservoir; during retraction of the plunger, the first one-way valve is positioned to prevent flow through the first connector into the syringe, and the second one-way valve is positioned to allow flow of the irrigation fluid from the irrigation reservoir to the syringe; depression of the plunger is configured to cause the irrigation fluid to flow from the syringe into the outer lumen; 15. The system of claim 14, wherein during depression of the plunger, the first one-way valve is positioned to allow flow of the irrigation fluid through the first connector into the outer lumen, and the second one-way valve is positioned to prevent flow of the irrigation fluid from the syringe through the second connector into the irrigation reservoir.

16. an aspiration flow control assembly fluidly coupled between the aspiration source and the inner lumen, the aspiration flow control assembly comprising: a first connector configured to be fluidly connected to the inner lumen; a second connector configured to be fluidly connected to the waste reservoir; a first one-way valve positioned between the first connector and the suction source, the first one-way valve positioned to (a) allow fluid flow from the inner lumen through the first connector to the suction source, and (b) prevent fluid flow from the suction source to the inner lumen through the first connector; a suction flow control assembly including: a second one-way valve positioned between the second connector and the suction source, the second one-way valve positioned to (a) allow fluid flow from the suction source to the waste reservoir through the second connector, and (b) prevent fluid flow from the waste reservoir to the suction source through the second connector; an irrigation flow control assembly fluidly coupled between the irrigation source and the outer lumen, the aspiration flow control assembly comprising: a third connector configured to be fluidly connected to the outer lumen; a fourth connector configured to be fluidly connected to the irrigation reservoir; a third one-way valve positioned between the third connector and the irrigation source, the third one-way valve positioned to (a) allow fluid flow from the irrigation source through the third connector to the outer lumen, and (b) prevent fluid flow from the inner lumen through the third connector to the irrigation source; 2. The system of claim 1, further comprising an irrigation flow control assembly comprising: a fourth one-way valve positioned between the fourth connector and the irrigation source, the fourth one-way valve positioned to (a) allow fluid flow from the irrigation reservoir to the irrigation source through the fourth connector; and (b) prevent fluid flow from the irrigation source to the irrigation reservoir through the fourth connector.

17. the suction source is a first syringe having a first plunger; withdrawal of the first plunger is configured to aspirate material from the cavity through the inner lumen; During withdrawal of the first plunger, the first one-way valve is positioned to allow flow of the substance through the first connector and into the first syringe, and the second one-way valve is positioned to prevent flow from the waste reservoir to the first syringe; Depression of the first plunger is configured to cause the aspirated material to flow from the first syringe to the waste reservoir; During depression of the first plunger, the first one-way valve is positioned to prevent flow of the aspirated material through the first connector and into the inner lumen, and the second one-way valve is positioned to allow flow of the aspirated material from the first syringe through the second connector and into the waste reservoir; the irrigation source is a second syringe having a second plunger; retraction of the second plunger is configured to at least partially fill the second syringe with irrigation fluid from the irrigation reservoir; during retraction of the second plunger, the third one-way valve is positioned to prevent flow through the third connector into the second syringe, and the fourth one-way valve is positioned to allow flow of the irrigation fluid from the irrigation reservoir to the second syringe; depression of the second plunger is configured to cause the irrigation fluid to flow from the second syringe into the outer lumen; 17. The system of claim 16, wherein during depression of the second plunger, the third one-way valve is positioned to allow flow of the irrigation fluid into the outer lumen through the third connector, and the fourth one-way valve is positioned to prevent flow of the irrigation fluid from the second syringe through the fourth connector into the irrigation reservoir.

18. 20. The system of claim 17, wherein the first plunger and the second plunger are mechanically coupled and configured to move together.

19. The system of claim 1 , wherein the inner elongate member is a reinforced catheter and the outer elongate member is a tube formed from a plastic material.

20. 1. A method of treating material in a body cavity of a patient, comprising: percutaneously inserting a catheter assembly into the patient such that a distal portion of the catheter assembly is within the cavity; aspirating material from the cavity through an inner lumen of the catheter assembly; and flowing irrigation fluid through an outer lumen of the catheter assembly and out an outer aperture of the catheter assembly into the cavity to irrigate the cavity, wherein the outer lumen is coaxial with the inner lumen.

21. inserting a mechanical disruptor element through the inner lumen; expanding the mechanical disruptor element within the cavity; 21. The method of claim 20, further comprising engaging the mechanical disruptor element with the material in the cavity to mechanically disrupt the material.

22. 21. The method of claim 20, wherein aspirating the substance from the cavity comprises actuating a syringe fluidly connected to the inner lumen.

23. 21. The method of claim 20, wherein flowing the irrigation fluid through the outer lumen comprises actuating a syringe fluidly connected to the outer lumen.

24. 21. The method of claim 20, wherein aspirating the material from the cavity comprises withdrawing a plunger of an aspirating syringe fluidly connected to the inner lumen, and flowing the irrigation fluid through the outer lumen comprises depressing a plunger of an irrigation syringe fluidly connected to the outer lumen.

25. The method comprises: withdrawing the plunger of the irrigation syringe to draw the irrigation fluid into the irrigation syringe; 25. The method of claim 24, further comprising depressing the plunger of the aspirating syringe to expel the aspirated substance from the aspirating syringe.

26. The method comprises: simultaneously withdrawing the plunger of the aspirating syringe to aspirate the material from the cavity and withdrawing the plunger of the irrigating syringe to draw the irrigation fluid into the irrigating syringe; 26. The method of claim 25, further comprising simultaneously depressing the plunger of the aspirating syringe to expel the aspirated material from the aspirating syringe and depressing the plunger of the irrigation syringe to cause the irrigation fluid to flow into the cavity to irrigate the cavity.

27. 27. The method of claim 26, wherein the plunger of the aspiration syringe and the plunger of the irrigation syringe are mechanically coupled to move together.

28. 1. A system for aspirating and irrigating a body cavity, comprising:

1. A catheter assembly comprising: an outer elongate member defining an outer lumen; a catheter assembly including an inner elongate member extending at least partially through the outer elongate member and defining an inner lumen having a distal opening, a distal portion of the outer elongate member being fluid-sealed to the inner elongate member, the outer elongate member including an aperture located proximally of the distal portion; an aspiration syringe fluidly connected to the inner lumen and configured to aspirate the inner lumen; an irrigation syringe fluidly connected to the outer lumen and configured to flow irrigation fluid through the outer lumen and out the aperture.

29. 30. The system of claim 28, wherein the aspiration syringe and the irrigation syringe are mechanically coupled to operate in synchronization.

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