The invention relates to a nano-wet wipe with rain, fog, and water scale proof functions. The nano-wet wipe includes an inner non-woven fabric substrate and an outer non-woven fabric substrate. A water barrier film is disposed at the upper end of the inner non-woven fabric substrate in the wet wipe, so that the upper and lower end faces of the wet wipe becomes two independently usable individuals,when water spots on glass need to be wiped, the wet wipe end face with the outer non-woven fabric substrate is employed to wipe the glass, the cooperative use of inner absorbent cotton and outer absorbent cotton and the effect of the absorbent cotton are conducive to improving the water absorption capacity of the outer non-woven fabric substrate, thus realizing rapid water absorption of the wet wipe, at the end of wiping, the other end face of the wet wipe is utilized to wipe the glass, after contact wiping of an efficient rain and fog proof nano-coating on the other end face of the wet wipeto the glass, the surface tension of water molecules is changed, and a very thin water film is formed on the glass surface, thereby realizing the rainwater and fog proof functions of the glass, afterwiping, rainwater does not stay on the glass surface easily, so that dust cannot be adhered easily, and water scale can be hardly produced.