bactericidal components

Abstract

A fungicidal composition comprising a mixture of components (A) and (B) as defined in claim 1 and the use of the composition in agriculture or horticulture to control or prevent infestation of plants by phytopathogenic microorganisms, preferably fungi.

Description

[Technical Field]

[0001] The present invention relates to novel fungicidal compositions and their use in agriculture or horticulture for controlling diseases caused by plant pathogens, in particular phytopathogenic fungi, and to methods for controlling diseases of useful plants. [Background technology]

[0002] While many fungicidal compounds and compositions belonging to various different chemical classes have been and are being developed for use as fungicides in useful plant crops, crop resistance and efficacy against specific plant pathogenic fungi often fall short of the demands of agricultural practice. Thus, there continues to be a need to find new compounds and compositions with superior biological properties for use in controlling or preventing plant infestation by plant pathogenic fungi, such as compounds with higher biological activity, a favorable spectrum of activity, an increased safety profile, improved physicochemical properties, and increased biodegradability. Alternatively, compositions with a broader spectrum of activity, improved crop resistance, synergistic interactions, or potentiating properties, or compositions that exhibit a more rapid onset of action or have longer residual activity, or that allow for fewer applications and / or reduced application rates of compounds and compositions necessary for effective control of plant pathogens, thereby enabling beneficial resistance management, reduced environmental impact, and reduced operator exposure.

[0003] The use of compositions containing mixtures of different fungicidal compounds with different modes of action can address some of these needs (e.g., by combining fungicides with different activity spectra). Summary of the Invention [Means for solving the problem]

[0004] According to the present invention, there is provided a fungicidal composition comprising a mixture of components (A) and (B) as active ingredients, wherein component (A) is a compound of formula (I): [ka] (In the formula, R 1 is selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, or C3-C6 cycloalkyl; R 2 is hydrogen, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, C1-C 4- selected from haloalkyl, C3-C6 cycloalkyl, C1-C4 alkylcarbonyl, N—C1-C4 alkoxy-C—C1-C4-alkyl-carbonimidoyl, N-hydroxy-C—C1-C4 alkyl-carbonimidoyl or C1-C4 alkoxycarbonyl; R 3 and R 4 are independently selected from hydrogen, halogen, or C1-C4 alkyl; R 5 and R 6 are independently selected from hydrogen or C1-C4 alkyl; R 7 is selected from hydrogen, C1-C4 alkyl, C1-C4 alkylcarbonyl, N-C1-C4 alkoxy-C-C1-C4 alkyl-carbonimidoyl, N-hydroxy-C-C1-C4 alkyl-carbonimidoyl, C1-C4 alkoxycarbonyl, N-methoxy-N-methyl-carbonyl, C1-C4 alkylaminocarbonyl, di(C1-C4 alkyl)aminocarbonyl, phenyl, 5- or 6-membered heteroaryl or C3-C6 cycloalkyl, wherein said 5- or 6-membered heteroaryl contains 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, provided that not more than one is O or S, and any of said phenyl, 5- or 6-membered heteroaryl and C3-C6 cycloalkyl is unsubstituted or substituted by 1, 2 or 3 substituents independently selected from halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl or C1-C4 alkoxy; B 1 is CR 10 or N, B2 is CR 11 or N, R 8 , R 9 , R 10 and R 11 are independently hydrogen, halogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C2-C4 alkenyloxy, C2-C4 alkynyloxy, C1-C4 alkylsulfanyl, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkoxy-C1-C4 alkyl, C1-C4 alkoxycarbonyl, C1-C4 alkylcarbonyl, N-C1-C4 alkoxy-C-C1-C4 alkyl-carbonimidoyl, N-hydroxy-C-C1-C4 alkyl-carbonimidoyl, hydroxy, triflate wherein said phenyl, 5- or 6-membered heteroaryl and C3-C6-cycloalkyl contain 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, provided that not more than one is O or S; and wherein any of said phenyl, 5- or 6-membered heteroaryl and C3-C6-cycloalkyl is unsubstituted or substituted by 1, 2 or 3 substituents independently selected from halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl or C1-C4 alkoxy; A 1 , A 2 and A 3 is independently 12 , N, NR 13 , O or S, with the proviso that A 1 , A 2 and A 3 is selected from N, O and S, and A 1 , A 2 and A 3 is O or S, R 12 is selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, or C2-C4 alkynyl; R 13is selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, or C2-C4 alkynyl, and Z 1 is selected from C3-C4 alkyl, phenyl, 5- or 6-membered heteroaryl, and C3-C6 cycloalkyl, wherein said 5- or 6-membered heteroaryl contains 1, 2, 3, or 4 heteroatoms individually selected from N, O, and S, provided that not more than one is O or S, and any of said phenyl, 5- or 6-membered heteroaryl, and C3-C6 cycloalkyl is unsubstituted or substituted by 1, 2, or 3 substituents independently selected from halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylsulfanyl, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, or C2-C4 alkynyl. is a compound of the formula: Ingredient (B) is pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumide, isoflucipram, inpirfluxam, isofetamide, fluindapyr, cyclobutrifluram, fluoxastrobin, fenamidone, mandestrobin, picoxystrobin, pyraclostrobin, famoxadone, kresoxim-methyl, trifloxystrobin, azoxystrobin, methyltetraprole, Amisulbrom, cyazofamid, fenpicoxamide, florylpicoxamide, methallylpicoxamide, ametoctrazine, fluazinam, triphenyltin hydroxide, silthiofam, fenpropimorph, fenpropidin, spiroxamine, fenhexamid, imazalil, pyrisoxazole, bromuconazole, cyproconazole, difenoconazole, epoxiconazole, flutriafol, hexaconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, tebuconazole, tetraconazole fluoxetine, triticonazole, prothioconazole, fluoxythioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, kasugamycin, mancozeb, copper fungicides, sulfur, zinc thiazole, captan, folpet, chlorothalonil, dithianon, quinoxyfen, proquinazide, fludioxonil, iprodione, procymidone, thiabendazole, zoxamide, metrafenone, fluopicolide, propamocarb, oxathiapiproline, fluoxetine, fluoxetine, fluoxetine-1, fluoxetine-2, fluoxetine-3, fluoxetine-4, fluoxetine-5, fluoxetine-6, fluoxetine-7, fluoxetine-8, fluoxetine-9, fluoxetine-10, fluoxetine-11, fluoxetine-12, fluoxetine-13, fluoxetine-14, fluoxetine-15, fluoxetine-15, fluoxetine-16, fluoxetine-17, fluoxetine-18, fluoxetine-19, fluoxetine-20, fluoxetine-21, fluoxetine-22, fluoxetine-23, fluoxetine-24, fluoxetine-25, fluoxetine-26, fluoxetine-27, fluoxetine-28, fluoxetine-29 ... Xapiproline, acibenzolar-S-methyl, isotianil, phosphorous acid, cyflufenamid, tebufloquine, picarbutrazox, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-Oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro -quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-Dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, Methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, Methyl (Z)-3-methoxy-2-[2-methyl-5-(4- propyltriazol-2-yl)phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2 -methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)yl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (an extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide), Reynoutria sachalinensis extract (commercially available as REGALIA®), a botanical extract based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®), and aureobasidin A.

[0005] According to a first aspect of the present invention there is provided a fungicidal composition comprising as active ingredients a mixture of components (A) and (B), wherein component (A) is a compound of formula (I), with the proviso that the compound of formula (I) is not the following or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer or N-oxide thereof:

[0006] [Table 1-1]

[0007] [Table 1-2]

[0008] [Table 1-3]

[0009] The PubChem Compound IDs assigned to the compounds excluded from the above claims refer to the identification numbers of each compound on the PubChem website (https: / / pubchem.ncbi.nlm.nih.gov / ).

[0010] The term "compound of formula (I)" refers to component A.

[0011] Typically, the weight ratio of component (A) to component (B) may preferably be 100:1 to 1:100, 50:1 to 1:50, 20:1 to 1:40, 15:1 to 1:30, 12:1 to 1:25, 10:1 to 1:20, 5:1 to 1:15, 3:1 to 1:10, or 2:1 to 1:5.

[0012] Furthermore, the present invention provides a method for controlling or preventing phytopathogenic diseases, in particular phytopathogenic fungi, of useful plants or their propagation material, which method comprises applying a fungicidal composition according to the present invention to useful plants, their habitats or their propagation material.

[0013] The benefits provided by certain fungicidal mixture compositions according to the invention may include, in particular, advantageous levels of biological activity for protecting plants from diseases caused by fungi or superior properties for use as pesticide active ingredients (e.g., high biological activity, advantageous activity spectrum, increased safety profile, improved physicochemical properties or increased biodegradability).

[0014] The presence of one or more possible asymmetric carbon atoms in the compounds of formula (I) means that the compounds can exist in the form of optical isomers, i.e., enantiomers or diastereomers. As a result of restricted rotation about a single bond, atropisomers may also occur. The present invention includes all possible isomeric forms (e.g., geometric isomers) of the compounds of formula (I) and mixtures thereof. The present invention also includes all possible tautomeric forms and racemates (i.e., mixtures of at least two enantiomers in a substantially 50:50 ratio) of the compounds of formula (I).

[0015] In each case, the compounds of formula (I) according to the invention are in free form, in oxidized form as N-oxides or in salt form, for example in agriculturally acceptable salt form.

[0016] N-oxides are the oxidized forms of tertiary amines or nitrogen-containing heteroaromatic compounds, as described, for example, in the book "Heterocyclic N-oxides" by A. Albini and S. Pietra, CRC Press, Boca Raton 1991.

[0017] The compounds of formula (I) according to the invention also include the hydrates which may be formed during salt formation.

[0018] When substituents are indicated as "optionally substituted," this means that they may be substituted with one or more of the same or different substituents, for example, one, two, or three R x It means that it may or may not have a substituent. For example, C1-C6 alkyl substituted with 1, 2 or 3 halogens includes -CH2Cl, -CHCl2, -CCl 3、Examples include, but are not limited to, -CHF, -CHF, -CF, -CHCF, or -CFCH groups. As another example, C1-C6 alkoxy substituted with 1, 2, or 3 halogens includes, but is not limited to, CH2ClO-, CHCl2O-, CCl3O-, CH2FO-, CHF2O-, CF3O-, CF3CHO-, or CH3CF2O- groups. Furthermore, the term "optionally substituted" as used herein can be used interchangeably with the term "unsubstituted or substituted."

[0019] The term "halogen" or "halo" as used herein means fluorine (fluoro), chlorine (chloro), bromine (bromo) or iodine (iodo), preferably fluorine, chlorine or bromine. Likewise, this applies to halogen in combination with other meanings, such as haloalkyl, haloalkenyl, haloalkynyl, haloalkoxy and halocycloalkyl.

[0020] As used herein, "amino" refers to the group --NH.sub.2.

[0021] As used herein, "cyano" refers to a -CN group.

[0022] The term "hydroxyl" or "hydroxy" as used herein means an --OH group.

[0023] As used herein, the term "carboxylic acid" refers to a -COOH group.

[0024] As used herein, "C1-C nThe term "-alkyl" refers to a saturated linear or branched hydrocarbon group having 1 to n carbon atoms and bonded via any carbon atom, such as any one of methyl, ethyl, n-propyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, or 1-ethyl-2-methylpropyl.

[0025] As used herein, "C2-C n The term "-alkenyl" refers to a straight or branched alkenyl chain moiety having 2 to n carbon atoms and one or two double bonds, for example ethenyl, prop-1-enyl, but-2-enyl.

[0026] As used herein, "C2-C n The term "-alkynyl" refers to a straight or branched alkynyl chain moiety having 2 to n carbon atoms and one triple bond, for example ethynyl, prop-2-ynyl, but-3-ynyl.

[0027] As used herein, "C3-C n The term "cycloalkyl" refers to 3 to n-membered cycloalkyl groups, such as cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl.

[0028] As used herein, "C1-C nThe term "C2-C alkoxy" refers to any one of the linear or branched saturated alkyl groups (as described above) having 1 to n carbon atoms attached via an oxygen atom, i.e., for example, methoxy, ethoxy, n-propoxy, 1-methylethoxy, n-butoxy, 1-methylpropoxy, 2-methylpropoxy, and 1,1-dimethylethoxy. n The term "-alkenyloxy" refers to a straight or branched alkenyl chain (as described above) having 2 to n carbon atoms attached via an oxygen atom.

[0029] As used herein, "C2-C n The term "alkynyloxy" refers to the R a However, as generally defined above, C2~C n an alkynyl group of the formula -OR a Refers to the group of

[0030] As used herein, "C1-C n -Alkoxy-C1~C n The term "-alkyl" refers to C1-C n -refers to an alkyl group (as defined above) substituted with an alkoxy group. Examples are methoxymethyl, methoxyethyl, ethoxymethyl and propoxymethyl.

[0031] As used herein, "C1-C nThe term "haloalkyl" refers to a linear or branched saturated alkyl group having 1 to n carbon atoms (as defined above) bonded via any of the carbon atoms, in which some or all of the hydrogen atoms of the group may be replaced by fluorine, chlorine, bromine and / or iodine, i.e., for example, chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2, It refers to any one of 2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 2-fluoropropyl, 3-fluoropropyl, 2,2-difluoropropyl, 2,3-difluoropropyl, 2-chloropropyl, 3-chloropropyl, 2,3-dichloropropyl, 2-bromopropyl, 3-bromopropyl, 3,3,3-trifluoropropyl, 3,3,3-trichloropropyl, 2,2,3,3,3-pentafluoropropyl, heptafluoropropyl, 1-(fluoromethyl)-2-fluoroethyl, 1-(chloromethyl)-2-chloroethyl, 1-(bromomethyl)-2-bromoethyl, 4-fluorobutyl, 4-chlorobutyl, 4-bromobutyl, and nonafluorobutyl. Thus, the term "C1-C2 fluoroalkyl" refers to any one of C1-C2 alkyl groups having 1, 2, 3, 4 or 5 fluorine atoms, such as difluoromethyl, trifluoromethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl or pentafluoroethyl. Similarly, as used herein, "C2-C n -haloalkenyl" or "C2-C n The term "haloalkynyl" refers to a C-C alkyl group substituted with one or more halogen atoms, each of which may be the same or different. n -alkenyl or C2-C nSimilarly, as used herein, "C3-C" refers to an -alkynyl group. n -halocycloalkyl" or "C1-C n The term "haloalkoxy" refers to a C-C alkyl group substituted with one or more halogen atoms, each of which may be the same or different. n -cycloalkyl group or C1-C n -refers to an alkoxyl group.

[0032] As used herein, "C1-C n -alkylthio" or "C1-C n -Alkylsulfanyl" refers to a C1-C alkyl group bonded via a sulfur atom. n -refers to alkyl groups.

[0033] As used herein, "C1-C n -haloalkylthio" or "C1-C n The term "haloalkylsulfanyl" refers to a C-C alkyl group bonded through a sulfur atom. n Refers to haloalkyl groups.

[0034] As used herein, "C1-C n The term "-alkylsulfinyl" refers to a C1-C alkylsulfinyl group bonded through the sulfur atom of the sulfinyl (or S(=O)-) group. n Refers to an alkyl group.

[0035] As used herein, "C1-C n The term "-alkylsulfonyl" refers to a C1-C2 alkyl group bonded through the sulfur atom of the sulfonyl (or S(=O)2-) group. n Refers to an alkyl group.

[0036] As used herein, "C1-C n The term "-alkylcarbonyl" refers to a C1-C alkyl group bonded through the carbon atom of a carbonyl (C=O) group. n -refers to alkyl groups.

[0037] As used herein, "C1-C nThe term "-alkoxycarbonyl" refers to a C1-C alkoxycarbonyl bonded through the carbon atom of a carbonyl (or C=O) group. n -refers to the alkoxy moiety.

[0038] The term "benzoyl," as used herein, refers to a phenyl group attached through the carbon atom of a carbonyl (C=O) group.

[0039] As used herein, "C1-C n The term "alkylaminocarbonyl" refers to a C1-C alkylaminocarbonyl group bonded through the carbon atom of a carbonyl (C=O) group. n Alkylamino group (or R a NHC(=O)-(wherein, R a is C1~C n It refers to an alkyl group.

[0040] As used herein, the term "N-Ci-Cn alkylamino" refers to a group of the formula -NH-R a where R a is a C1-Cn alkyl group as defined above).

[0041] As used herein, "N,N-diC1-C n The term "alkylamino" refers to a group of the formula -N(R a )R a wherein each R a refers to a C1-Cn alkyl group, which may be the same or different, as defined above.

[0042] As used herein, the term “N—C1-C4 alkoxy-C—C1-C4 alkyl-carbonimidoyl” refers to a group of the formula —C(R a )=NO(R b )(wherein, R a is a C1-C4 alkyl group as generally defined above, and R b refers to a group of which C1-C4 alkyl group is as generally defined above.

[0043] As used herein, the term “N-hydroxy-C—Ci-C4 alkyl-carbonimidoyl” refers to a group of the formula —C(R a )=NOH(where R a is a C1-C4 alkyl group as generally defined above).

[0044] The term "heteroaryl," as used herein, refers to a 5- or 6-membered aromatic monocyclic ring group containing 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S. Examples of heteroaryl include, but are not limited to, furanyl, pyrrolyl, thienyl, pyrazolyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, tetrazolyl, pyrazinyl, pyridazinyl, pyrimidyl, or pyridyl. "Heteroaryl" refers to a C1-C6 heteroaryl group. n Alkyl" or "Heteroaryl C3-C n The term "cycloalkyl" refers to C1-C6 alkyl groups each substituted with a heteroaryl group. n Alkyl or C3-C n It refers to a cycloalkyl group. Heteroaryl C1-C n Alkyl or heteroaryl C3-C n Cycloalkyl groups can be optionally substituted on the heteroaryl, alkyl and / or cycloalkyl group.

[0045] As used herein, the term "controlling" refers to reducing the number of pests, eliminating pests, and / or preventing further pest damage so that damage to plants or plant-derived products is reduced.

[0046] As used herein, the term "pest" refers to insects and mollusks found in agriculture, horticulture, forestry, storing plant-derived products (such as fruit, grain, and timber), and pests associated with damaging man-made structures. The term pest includes all stages of the pest life cycle.

[0047] As used herein, the term "effective amount" refers to an amount of a compound or a salt thereof that produces a desired effect upon single or multiple applications.

[0048] Effective amounts are readily determined by those skilled in the art using known techniques and by observing results obtained under similar circumstances. In determining an effective amount, several factors are taken into consideration, including, but not limited to, the type of plant or derived product to be applied, the pest to be controlled and its life cycle, the particular compound applied, the type of application, and other relevant circumstances.

[0049] As used herein, the terms "room temperature" or "RT" or "rt" or "ambient temperature" refer to a temperature of about 15° C. to about 35° C. For example, rt can refer to a temperature of about 20° C. to about 30° C.

[0050] The following list refers to compounds of formula (I) of the present invention and defines substituent R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 , B 2 , A 1 , A 2 , A 3 and Z 1 For any one of these substituents, any definition given below may be combined with any definition of any other substituent given below or elsewhere in this specification. DETAILED DESCRIPTION OF THE INVENTION

[0051] In one embodiment of the present invention, R 1 is hydrogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, or C3-C6 cycloalkyl. 1 is C1-C4 alkyl. Preferably, R 1is methyl, ethyl or isopropyl. More preferably, R 1 is methyl.

[0052] In one embodiment of the present invention, R 2 is selected from hydrogen, halogen, C1-C4 alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C3-C6 cycloalkyl, C1-C4 alkylcarbonyl, N-C1-C4 alkoxy-C-C1-C4 alkyl-carbonimidoyl, N-hydroxy-C-C1-C4 alkyl-carbonimidoyl or C1-C4 alkoxycarbonyl. 2 is hydrogen, halogen, C1-C4-alkyl, C3-C6 cycloalkyl, C1-C4 alkylcarbonyl, N-C1-C4 alkoxyC1-C4 alkyl-carbonimidoyl or N-hydroxyC1-C4 alkyl-carbonimidoyl. 2 is hydrogen, halogen, methyl, ethyl, cyclopropyl, C1-C2-alkylcarbonyl, N-C1-C2 alkoxy-C-C1-C2 alkyl-carbonimidoyl or N-hydroxy-C-C1-C2 alkyl-carbonimidoyl. More preferably, R 2 is hydrogen, fluorine, chlorine, bromine, methyl, ethyl, cyclopropyl, acetyl, -C(CH3)=NOCH3, -C(CH3)=NOCH2CH3 or -C(CH3)=NOH. In a preferred embodiment of the present invention, R 2 is selected from hydrogen, halogen, or C1-C4 alkyl. Most preferably, R 2 is hydrogen, chlorine or methyl. In one preferred embodiment, R 2 is hydrogen. In another preferred embodiment, R 2 is methyl. In yet another embodiment, R 2 is chlorine.

[0053] In one embodiment, R 3 is selected from hydrogen, halogen, C1-C4 haloalkyl or C1-C4 alkyl. Preferably, R 3is hydrogen or C1-C4 alkyl. More preferably, R 3 is hydrogen or methyl. Most preferably, R 3 is hydrogen.

[0054] In one embodiment of the present invention, R 4 is hydrogen, halogen, C1-C4 alkyl, C1-C4 haloalkyl or C3-C6-cycloalkyl. Preferably, R 4 is hydrogen, chlorine, bromine, fluorine, methyl, ethyl, trifluoromethyl, difluoromethyl or cyclopropyl. More preferably, R 4 is hydrogen, chlorine, bromine or methyl. Even more preferably, R 4 is hydrogen or methyl. Most preferably, R 4 is hydrogen. In one embodiment of the present invention, R 4 is hydrogen. In another embodiment of the present invention, R 4 is methyl.

[0055] In one embodiment of the present invention, R 5 and R 6 are independently selected from hydrogen or C1-C4 alkyl. 5 and R 6 are independently selected from hydrogen, methyl or ethyl. More preferably, R 5 and R 6 are independently selected from hydrogen or methyl. Even more preferably, R 5 and R 6 is hydrogen.

[0056] In one embodiment, R 7is selected from hydrogen, C1-C4 alkyl, C1-C4-alkylcarbonyl, N-C1-C4 alkoxy-C-C1-C4 alkyl-carbonimidoyl, N-hydroxy-C-C1-C4 alkyl-carbonimidoyl, C1-C4-alkoxycarbonyl, N-methoxy-N-methyl-carbonyl, C1-C4 alkylaminocarbonyl, di(C1-C4 alkylamino)carbonyl, phenyl, 5- to 6-membered heteroaryl or C3-C6-cycloalkyl, wherein said 5- or 6-membered heteroaryl is selected from 1, 2, 3 or 4 alkyl groups individually selected from N, O and S. wherein not more than one is O or S, and said phenyl and 5- to 6-membered heteroaryl are unsubstituted or substituted with 1, 2 or 3 substituents independently selected from halogen, C1-C4 haloalkyl, cyano, carboxy, C1-C4 alkyl or C1-C4 alkoxy, and said C3-C6-cycloalkyl is unsubstituted or substituted with 1, 2 or 3 substituents independently selected from halogen, C1-C4 haloalkyl, cyano, C1-C4 alkyl or C1-C4 alkoxy.

[0057] In another embodiment of the present invention, R 7 is selected from hydrogen, C1-C4 alkyl, C1-C4 alkylcarbonyl, C1-C4 alkoxycarbonyl, N-C1-C4 alkoxy-C-C1-C4 alkyl-carbonimidoyl, N-hydroxy-C-C1-C4 alkyl-carbonimidoyl, N-methoxy-N-methyl-carbonyl, C1-C4 alkylaminocarbonyl, di(C1-C4 alkylamino)carbonyl, phenyl, 5- to 6-membered heteroaryl, or C3-C6 cycloalkyl, wherein the 5- to 6-membered heteroaryl contains one heteroatom selected from N, and the phenyl and 5- to 6-membered heteroaryl are unsubstituted or substituted with one to two substituents independently selected from halogen, C1-C4 haloalkyl, cyano, or C1-C4 alkyl, and the C3-C6 cycloalkyl is unsubstituted or substituted with one substituent selected from cyano. Preferably, R 7is selected from hydrogen, methyl, acetyl, -C(CH3)=NOCH3, -C(CH3)=NOCH2CH3, -C(CH3)=NOH, methoxycarbonyl, ethoxycarbonyl, N-methoxy-N-methyl-carbonyl, methylaminocarbonyl, dimethylaminocarbonyl, phenyl, 2-cyanophenyl, 3-cyanophenyl, 4-cyanophenyl, [4-(trifluoromethyl)pyrazol-1-yl], [3-(trifluoromethyl)pyrazol-1-yl], 3-cyanopyrazol-1-yl, 4-cyanopyrazol-1-yl, 5-chloropyrazol-1-yl, 5-fluoropyrazol-1-yl, 3,5-dimethylpyrazol-1-yl, 5-methylpyrazol-1-yl, pyrazol-1-yl, cyclopropyl or 1-cyanocyclopropyl. More preferably, R 7 is selected from hydrogen, methyl, acetyl, -C(CH3)=NOCH3, -C(CH3)=NOCH2CH3, -C(CH3)=NOH, phenyl, 4-cyanophenyl, pyrazol-1-yl, cyclopropyl or 1-cyanocyclopropyl. Even more preferably, R 7 is selected from hydrogen, methyl, cyclopropyl or 1-cyanocyclopropyl.

[0058] In another embodiment, R 7 is selected from hydrogen, C1-C4 alkyl or C3-C6-cycloalkyl. 7 is hydrogen, methyl, cyclopropyl or 1-cyanocyclopropyl. Even more preferably, R 7 is hydrogen, methyl or cyclopropyl.

[0059] In another preferred embodiment, R 7 is C1-C4 alkyl. Preferably, R 7 is methyl or ethyl. More preferably, R 7 is methyl.

[0060] In one embodiment of the present invention, R 8 , R 9 , R 10 and R 11is hydrogen, halogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C2-C4 alkenyloxy, C2-C4 alkynyloxy, C1-C4 alkylsulfanyl, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkoxy-C1-C4 alkyl, C1-C4 alkoxycarbonyl, C1-C4 alkylcarbonyl, N-C1-C4 alkoxy-C-C1-C4 alkyl-carbonimidoyl, N-hydroxy-C-C1-C4 alkyl-carbonimidoyl, hydroxy, trifluoromethyl wherein said 5- or 6-membered heteroaryl contains 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, provided that not more than one is O or S; and wherein any of said phenyl, 5- or 6-membered heteroaryl and C3-C6-cycloalkyl is unsubstituted or substituted by 1, 2 or 3 substituents independently selected from halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl or C1-C4 alkoxy; In one embodiment of the present invention, R 8 and R 9 are independently selected from hydrogen, halogen, cyano, C1-C4 alkyl, or C1-C4 alkoxy. 8 and R 9 are independently selected from hydrogen, halogen, methyl, methoxy or cyano. More preferably, R 8 and R 9 are independently selected from hydrogen, methyl, chlorine, fluorine, bromine or methoxy. Even more preferably, R 8 and R 9 is independently selected from hydrogen or methyl.

[0061] In another embodiment of the present invention, R 8 is hydrogen, halogen or cyano. Preferably, R 8 is hydrogen, bromine, chlorine or cyano. More preferably, R 8is hydrogen, cyano or bromine. Even more preferably, R 8 is hydrogen.

[0062] In another embodiment, R 9 is hydrogen, halogen, C1-C3 alkyl, C1-C2 haloalkyl, C1-C3 haloalkoxy, C1-C4 alkoxy, C1-C3 alkenyloxy, C1-C3 alkynyloxy, C1-C2 alkylsulfanyl, C1-C2 alkylsulfinyl, C1-C2 alkylsulfonyl, C1-C2 alkoxy-C1-C2 alkyl, C1-C3 alkoxycarbonyl, C1-C2 alkylcarbonyl, N-C1-C2 alkoxy-C-C1-C2 alkyl-carbonimidoyl, N-hydroxy-C-C1-C2 alkyl-carbonimidoylhydroxy, C1-C2 alkylaminocarbonyl, di(C1-C2 alkylamino)carbonyl, trifluoromethylsulfonyloxy, cyano, carboxy, phenyl, 2-cyanophenyl, 3- cyanophenyl, 4-cyanophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, [4-(trifluoromethyl)pyrazol-1-yl], [3-(trifluoromethyl)pyrazol-1-yl], 3-cyanopyrazol-1-yl, 4-cyanopyrazol-1-yl, 5-chloropyrazol-1-yl, 4-chloropyrazol-1-yl, 3-chloropyrazol-1-yl, 5-fluoropyrazol-1-yl, 4-fluoropyrazol-1-yl, 3-fluoropyrazol-1-yl, 3,5-dimethylpyrazol-1-yl, 5-methylpyrazol-1-yl, 4-methylpyrazol-1-yl, 3-methylpyrazol-1-yl, pyrazol-1-yl, cyclopropyl or 1-cyanocyclopropyl. Preferably, R 9is hydrogen, chloro, fluoro, bromo, methyl, ethyl, trifluoromethyl, difluoromethyl, difluoromethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, methoxy, ethoxy, propoxy, allyloxy, prop-2-ynoxy, methylsulfanyl, methylsulfinyl, methylsulfonyl, methoxymethyl, ethoxymethyl, 2-methoxyethoxymethyl, methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl, acetyl, propanoyl, -C(CH3)=NOCH3, -C(CH3)=NOCH2CH3, -C(CH3)=NOH, methylaminocarbonyl, di(methylamino)carbonyl, trifluoromethylsulfonyloxy, cyano, carboxy, phenyl, 2-cyanophenoxy phenyl, 3-cyanophenyl, 4-cyanophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, [4-(trifluoromethyl)pyrazol-1-yl], [3-(trifluoromethyl)pyrazol-1-yl], 3-cyanopyrazol-1-yl, 4-cyanopyrazol-1-yl, 5-chloropyrazol-1-yl, 4-chloropyrazol-1-yl, 3-chloropyrazol-1-yl, 5-fluoropyrazol-1-yl, 4-fluoropyrazol-1-yl, 3-fluoropyrazol-1-yl, 3,5-dimethylpyrazol-1-yl, 5-methylpyrazol-1-yl, 4-methylpyrazol-1-yl, 3-methylpyrazol-1-yl, pyrazol-1-yl, cyclopropyl or 1-cyanocyclopropyl. 9is hydrogen, chloro, bromo, fluoro, cyano, methyl, methoxy, propoxy, allyloxy, methoxymethyl, 2-methoxyethoxymethyl, phenyl, 2-cyanophenyl, 3-cyanophenyl, 4-cyanophenyl, [4-(trifluoromethyl)pyrazol-1-yl], [3-(trifluoromethyl)pyrazol-1-yl], 3-cyanopyrazol-1-yl, 4-cyanopyrazol-1-yl, 5-chloropyrazol-1-yl, 4-chloropyrazol-1-yl, 3-chloropyrazol-1-yl, 5-fluoropyrazol-1-yl, 4-fluoropyrazol-1-yl, 3-fluoropyrazol-1-yl, 3,5-dimethylpyrazol-1-yl, 5-methylpyrazol-1-yl, 4-methylpyrazol-1-yl, 3-methylpyrazol-1-yl, pyrazol-1-yl, cyclopropyl or cyano 1-cyclopropyl. Even more preferably, R 9 is hydrogen, chloro, bromo, cyano, methyl or methoxy. Most preferably, R 9 is hydrogen or methoxy.

[0063] In one embodiment of the present invention, B 1 is CR 10 and B 2 is CR 11 or B 1 is N and B 2 is CR 11 or B 1 is CR 10 and B 2 is N. Preferably, B 1 is CR 10 and B 2 is CR 11 is.

[0064] In one embodiment of the present invention, R 10 and R 11is hydrogen, halogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C2-C4 alkenyloxy, C2-C4 alkynyloxy, C1-C4 alkylsulfanyl, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 alkoxy-C1-C4 alkyl, C1-C4 alkoxycarbonyl, C1-C4 alkylcarbonyl, N-C1-C4 alkoxy-C-C1-C4 alkyl-carbonimidoyl, N-hydroxy-C-C1-C4 alkyl-carbonimidoyl, hydroxy, trifluoromethylsulfonyl and R is independently selected from R(R)-R(R), ... 10 and R 11is hydrogen, chloro, fluoro, bromo, methyl, ethyl, trifluoromethyl, difluoromethyl, difluoromethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, methoxy, ethoxy, propoxy, allyloxy, prop-2-ynoxy, methylsulfanyl, methylsulfinyl, methylsulfonyl, methoxymethyl, ethoxymethyl, 2-methoxyethoxymethyl, methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl, acetyl, propanoyl, -C(CH3)=NOCH3, -C(CH3)=NOCH2CH3, -C(CH3)=NOH, methylaminocarbonyl, di(methylamino)carbonyl, trifluoromethylsulfonyloxy, cyano, carboxy, phenyl, 2-cyanophenyl, is selected from 3-cyanophenyl, 4-cyanophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, [4-(trifluoromethyl)pyrazol-1-yl], [3-(trifluoromethyl)pyrazol-1-yl], 3-cyanopyrazol-1-yl, 4-cyanopyrazol-1-yl, 5-chloropyrazol-1-yl, 4-chloropyrazol-1-yl, 3-chloropyrazol-1-yl, 5-fluoropyrazol-1-yl, 4-fluoropyrazol-1-yl, 3-fluoropyrazol-1-yl, 3,5-dimethylpyrazol-1-yl, 5-methylpyrazol-1-yl, 4-methylpyrazol-1-yl, 3-methylpyrazol-1-yl, pyrazol-1-yl, cyclopropyl, or 1-cyanocyclopropyl. More preferably, R 10 and R 11are independently hydrogen, chloro, bromo, fluoro, cyano, methyl, methoxy, propoxy, allyloxy, methoxymethyl, 2-methoxyethoxymethyl, phenyl, 2-cyanophenyl, 3-cyanophenyl, 4-cyanophenyl, [4-(trifluoromethyl)pyrazol-1-yl], [3-(trifluoromethyl)pyrazol-1-yl], 3-cyanopyrazol-1-yl, 4-cyanopyrazol-1-yl, 5-chloropyrazol-1-yl, 4-chloropyrazol-1-yl Even more preferably, R is selected from the group consisting of 3-chloropyrazol-1-yl, 5-fluoropyrazol-1-yl, 4-fluoropyrazol-1-yl, 3-fluoropyrazol-1-yl, 3,5-dimethylpyrazol-1-yl, 5-methylpyrazol-1-yl, 4-methylpyrazol-1-yl, 3-methylpyrazol-1-yl, pyrazol-1-yl, C(CH3)=NOCH3, —C(CH3)=NOCH2CH3, —C(CH3)=NOH, cyclopropyl, and 1-cyanocyclopropyl. 10 and R 11 is independently selected from hydrogen, chlorine, bromine, or cyano.

[0065] In another embodiment, R 10 and R 11 are independently selected from hydrogen, halogen, C1-C3 alkyl, or C1-C4 alkoxy. 10 and R 11 are independently selected from hydrogen or halogen. More preferably, R 10 and R 11 is hydrogen, bromine or chlorine. Even more preferably, R 10 and R 11 is hydrogen.

[0066] In one embodiment of the present invention, A 1 , A 2 and A 3 is independently 12 , N, NR 13 , O and S, with the proviso that A 1 , A 2 and A 3is selected from N, O and S, and A 1 , A 2 and A 3 is O or S. In another embodiment of the present invention, A 1 and A 2 is independently 12 , N and O; 3 is CR 12 , N, O or S, preferably A 1 and A 2 are independently selected from N and O; A 3 is CR 12 , O or S, provided that A 1 , A 2 and A 3 At least one of is N or O, and A 1 , A 2 and A 3 One or less of is O.

[0067] In one embodiment of the present invention, R 12 is hydrogen or C1-C4 alkyl. Preferably, R 12 is hydrogen or methyl. More preferably, R 12 is hydrogen.

[0068] In one embodiment of the present invention, R 13 is hydrogen or C1-C4 alkyl. Preferably, R 13 is hydrogen or methyl. More preferably, R 13 is hydrogen.

[0069] In one embodiment of the present invention, Z 1is selected from C3-C4 alkyl, phenyl, 5- or 6-membered heteroaryl, and C3-C6-cycloalkyl, wherein said 5- or 6-membered heteroaryl contains 1, 2, 3, or 4 heteroatoms individually selected from N, O, and S, provided that not more than one is O or S, and any of said phenyl, 5- or 6-membered heteroaryl, and C3-C6-cycloalkyl is unsubstituted or substituted by 1, 2, or 3 substituents independently selected from halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylsulfanyl, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, or C2-C4 alkynyl.

[0070] In another embodiment of the present invention, Z 1 is selected from phenyl, 5- to 6-membered heteroaryl, or C3-C6-cycloalkyl, wherein the 5- or 6-membered heteroaryl contains one heteroatom selected from N, and the phenyl and 5- to 6-membered heteroaryl are unsubstituted or substituted with one or two substituents independently selected from halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 haloalkoxy, or C1-C4 alkoxy, and the C3-C6-cycloalkyl is unsubstituted or substituted with one substituent selected from halogen or C1-C4 alkyl. Preferably, Z 1 is selected from phenyl or 5- to 6-membered heteroaryl, wherein said 5- or 6-membered heteroaryl contains one heteroatom selected from N, and said phenyl and 5- to 6-membered heteroaryl are unsubstituted or substituted with 1 or 2 substituents independently selected from fluoro, chloro, C1-C4 alkyl or C1-C4 alkoxy.

[0071] In another embodiment of the present invention, Z 1is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing 1 or 2 heteroatoms selected from N, said phenyl and 6-membered heteroaryl being unsubstituted or substituted by 1, 2 or 3 substituents independently selected from halogen, cyano, C1-C4 alkyl, C2-C4 alkynyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, C1-C4 alkylsulfanyl, C1-C4 alkylsulfinyl or C1-C4 alkylsulfonyl. Preferably, Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing 1 or 2 heteroatoms selected from N, said phenyl and 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents independently selected from halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 haloalkoxy or C1-C4 alkoxy. More preferably, Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing 1 or 2 heteroatoms selected from N, said phenyl and 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents independently selected from halogen or C1-C4 haloalkyl. Even more preferably, Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing 1 or 2 heteroatoms selected from N, said phenyl and said 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents selected from fluorine. Even more preferably, Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing one heteroatom selected from N, and said phenyl and said 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents selected from fluorine.

[0072] Preferably, Z 1is phenyl, 2,3,4-trifluorophenyl, 2,3-difluorophenyl, 3,4-difluorophenyl, 2,4,6-trifluorophenyl, 2,4-difluorophenyl, 2,5-difluorophenyl, 2-fluoro-4-methoxy-phenyl, 2-fluoro-4-methylsulfonyl-phenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3,6-difluoro-2-pyridyl, 4,6-difluoro-2-pyridyl, 4,5-difluoro-2-pyridyl, 5,6-difluoro-2-pyridyl, 3-fluoro-4-pyridyl, 2-fluoro-4-pyridyl, 2,3-difluoro More preferably, Z is selected from Z-fluoro-4-pyridyl, 2,5-difluoro-4-pyridyl, 2,6-difluoro-4-pyridyl, 3,5-difluoro-4-pyridyl, 2,5-difluoro-4-pyridyl, 2-fluoro-3-pyridyl, 6-fluoro-3-pyridyl, 5-fluoro-3-pyridyl, 4-fluoro-3-pyridyl, 2,6-difluoro-3-pyridyl, 2,5-difluoro-3-pyridyl, 2,4-difluoro-3-pyridyl, 4,6-difluoro-3-pyridyl, 5,6-difluoro-3-pyridyl, 3,5-difluoro-2-pyridyl, 3,4-difluoro-2-pyridyl, 6-fluoro-2-pyridyl, 4-fluoro-2-pyridyl, 5-fluoro-2-pyridyl, 3-fluoro-2-pyridyl, and 4,5-difluoro-3-pyridyl. 1 is selected from phenyl, 2,4-difluorophenyl, 2,5-difluorophenyl, 2-chlorophenyl, 2-fluorophenyl, 3,4-difluorophenyl, 3-chlorophenyl, 3-fluorophenyl, 3-methylphenyl, 4-fluorophenyl, 3-fluoro-2-pyridyl, 5-fluoro-2-pyridyl, 6-fluoro-2-pyridyl, 3,4-difluoro-2-pyridyl, 3,5-difluoro-2-pyridyl, 2-fluoro-4-pyridyl. Even more preferably, Z 1 is selected from 2,4-difluorophenyl, 3,5-difluoro-2-pyridyl, 2-fluorophenyl, 4-fluorophenyl or phenyl.

[0073] In the present invention, therefore, R as defined above 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 , B 2 , A 1 , A 2 , A 3 and Z 1 In one embodiment, compounds of formula (I) are provided having:

[0074] Embodiments according to the present invention are provided as follows.

[0075] The term "compound of formula (I)" refers to component A.

[0076] In one embodiment of the present invention, the compound of formula (I) has the formula (IA) [ka] wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 , B 2 and Z 1 is as defined for the compounds of formula (I) according to the invention, and A is A1 to A36 [ka] is selected from: [ka] indicates a bond to a C(=O) group, and the arrow indicates a bond to a Z 1indicates a bond to the group, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , B 1 , B 2 and Z 1 is as defined for the compounds of formula (I) according to the invention, and R 12a , R 13a , R 14a , R 12b , R 13b and R 14b are independently selected from hydrogen, C1-C4 alkyl, C2-C4 alkenyl, and C2-C4 alkynyl.

[0077] In one embodiment of the present invention, in the compound of formula (IA), R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 , B 2 and Z 1 is as defined for the compounds of formula (I) according to the invention, and A is [ka] is selected from: [ka] indicates a bond to a C(=O) group, and the arrow indicates a bond to a Z 1 indicates a bond to the group, and R 12a , R 13a and R 14a are independently selected from hydrogen or C1-C4 alkyl. Preferably, R 12a , R 13a and R 14a is hydrogen.

[0078] In another embodiment of the present invention, in the compound of formula (IA), R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 , B 2 and Z 1 is as defined for the compounds of formula (I) according to the invention, and A is [ka] is selected from: [ka] indicates a bond to a C(=O) group, and the arrow indicates a bond to a Z 1 indicates a bond to the group, and R 12a , R 13a and R 14a are independently selected from hydrogen or C1-C4 alkyl. Preferably, R 12a , R 13a and R 14a is hydrogen.

[0079] In another embodiment of the present invention, in the compound of formula (IA), R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 , B 2 and Z 1 is as defined for the compounds of formula (I) according to the invention, and A is [ka] is selected from: [ka] indicates a bond to a C(=O) group, and the arrow indicates a bond to a Z 1 indicates a bond to the group, and R 14a is selected from hydrogen or C1-C4 alkyl. Preferably, R 14a is hydrogen.

[0080] In another embodiment of the present invention, in the compound of formula (IA), R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 , B 2 and Z 1 is as defined for the compounds of formula (I) according to the invention, and A is [ka] is selected from: [ka] indicates a bond to a C(=O) group, and the arrow indicates a bond to a Z 1 indicates a bond to the group, and R 14a is selected from hydrogen or C1-C4 alkyl. Preferably, R 14a is hydrogen.

[0081] In one embodiment of the present invention, R 12a , R 13a , R 14a , R 12b , R 13b and R 14b are independently selected from hydrogen and methyl.

[0082] In another embodiment of the present invention, R 12a , R 13a , R 14a , R 12b , R 13b and R 14b is hydrogen.

[0083] In another embodiment of the present invention, R 12a , R 13a , R 14a , R 12b , R 13b and R 14b is methyl.

[0084] Preferably, in the compounds of formula (IA), A is selected from A4, A7 or A9, and R 14a is hydrogen.

[0085] In one embodiment, the compound of formula (I) may be a compound of formula (IA), wherein: R 1 is methyl, R 2 is hydrogen, chlorine or methyl, R 3 is hydrogen, R 4 is hydrogen or methyl, R 5 and R 6 is hydrogen, R 7 is hydrogen, C1-C4 alkyl or C3-C6-cycloalkyl, R 8 is hydrogen, bromine, chlorine or cyano; R 9 is hydrogen, bromine, chlorine, cyano, methyl or methoxy, B 1 is N or CR 10 and R 10 is hydrogen, bromine, chlorine or cyano; B 2 is N or CR 11 and R 11 is hydrogen, bromine, chlorine or cyano; A is A4, A6, A7, A9 or A10; Z 1is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing 1 or 2 heteroatoms selected from N, and said phenyl and said 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents selected from fluorine.

[0086] In another embodiment, the compound of formula (I) may be a compound of formula (IA), wherein: R 1 is methyl, R 2 is hydrogen, chlorine or methyl, R 3 is hydrogen, R 4 is hydrogen or methyl, R 5 and R 6 is hydrogen, R 7 is hydrogen, C1-C4 alkyl or C3-C6-cycloalkyl, R 8 is hydrogen, bromine, chlorine or cyano; R 9 is hydrogen, bromine, chlorine, cyano, methyl or methoxy, B 1 is CR 10 and R 10 is hydrogen, bromine, chlorine or cyano; B 2 is CR 11 and R 11 is hydrogen, bromine, chlorine or cyano; A is A4, A6, A7, A9 or A10; Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing 1 or 2 heteroatoms selected from N, and said phenyl and said 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents selected from fluorine.

[0087] In a further embodiment, the compound of formula (I) may be a compound of formula (IA), wherein: R1 is methyl, R 2 is hydrogen, chlorine or methyl, R 3 is hydrogen, R 4 is hydrogen or methyl, R 5 and R 6 is hydrogen, R 7 is hydrogen, C1-C4 alkyl or C3-C6-cycloalkyl, R 8 is hydrogen, bromine, chlorine or cyano; R 9 is hydrogen, bromine, chlorine, cyano, methyl or methoxy, B 1 is CR 10 and R 10 is hydrogen, bromine, chlorine or cyano; B 2 is CR 11 and R 11 is hydrogen, bromine, chlorine or cyano; A is A4, A7 or A9; Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing 1 or 2 heteroatoms selected from N, and said phenyl and said 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents selected from fluorine.

[0088] In a further embodiment, the compound of formula (I) may be a compound of formula (IA), wherein: R 1 is methyl, R 2 is hydrogen, chlorine or methyl, R 3 is hydrogen, R 4 is hydrogen or methyl, R 5 and R 6 is hydrogen, R 7is hydrogen, C1-C4 alkyl or C3-C6-cycloalkyl, R 8 is hydrogen, R 9 is hydrogen, bromine, chlorine, cyano, methyl or methoxy, B 1 is CH, B 2 is N or CR 11 and R 11 is hydrogen, A is selected from A1, A4, A7, A9 or A10; Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing one heteroatom selected from N, and said phenyl and said 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents selected from fluorine.

[0089] Preferably, component (A) is [5-(2,4-difluorophenyl)-1,3,4-oxadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.01), [3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.02), [4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-propyl-1,3,4-thiadiazol-2-yl)methanone (X.03), (5-cyclohexyl-1,3,4-thiadiazol-2-yl)-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.04), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.05), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[(4R)-4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.06), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.07), 1-[4-[2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-3,4-dihydro-1H-isoquinolin-4-yl]-2-methyl-pyrazol-3-yl]ethenone (X.08), Methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate (X.09), [5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.10), [4-(5-chloro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2,4-difluorophenyl)isoxazol-3-yl]methanone (X.11), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(5-fluoro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.12), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[3,3-dimethyl-4-(1-methylpyrazol-4-yl)-1,4-dihydroisoquinolin-2-yl]methanone (X.13), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.14), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[5-(1,3,5-trimethylpyrazol-4-yl)-6,8-dihydro-5H-1,7-naphthyridin-7-yl]methanone (X.15), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.16), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,2,4-oxadiazol-3-yl)methanone (X.17), (3-Cyclohexylisoxazol-5-yl)-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.18), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone (X.19), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.20), [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.21), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.22), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(4-pyridyl)isoxazol-3-yl]methanone (X.23), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(3-pyridyl)isoxazol-3-yl]methanone (X.24), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2-pyridyl)isoxazol-3-yl]methanone (X.25), [5-(6-methoxy-3-pyridyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.26), [5-(2-methoxy-3-pyridyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.27), [5-(3,5-difluoro-2-pyridyl)-1,3,4-thiadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.28), or [5-(2,6-difluoro-3-pyridyl)-1,3,4-thiadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.29), or A compound selected from the group consisting of one of their (S)- or (R)-enantiomers as defined in Table X below.

[0090] More preferably, component (A) is [5-(2,4-difluorophenyl)-1,3,4-oxadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.01), [3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.02), [4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-propyl-1,3,4-thiadiazol-2-yl)methanone (X.03), (5-cyclohexyl-1,3,4-thiadiazol-2-yl)-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.04), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.05), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[(4R)-4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.06), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.07), 1-[4-[2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-3,4-dihydro-1H-isoquinolin-4-yl]-2-methyl-pyrazol-3-yl]ethenone (X.08), Methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate (X.09), [5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.10), [4-(5-chloro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2,4-difluorophenyl)isoxazol-3-yl]methanone (X.11), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(5-fluoro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.12), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[3,3-dimethyl-4-(1-methylpyrazol-4-yl)-1,4-dihydroisoquinolin-2-yl]methanone (X.13), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.14), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[5-(1,3,5-trimethylpyrazol-4-yl)-6,8-dihydro-5H-1,7-naphthyridin-7-yl]methanone (X.15), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.16), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,2,4-oxadiazol-3-yl)methanone (X.17), (3-Cyclohexylisoxazol-5-yl)-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.18), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone (X.19), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.20), [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.21), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.22), [5-(3,5-difluoro-2-pyridyl)-1,3,4-thiadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.28), or [5-(2,6-difluoro-3-pyridyl)-1,3,4-thiadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.29), or A compound selected from the group consisting of one of their (S)- or (R)-enantiomers as defined in Table X below.

[0091] Even more preferably, component (A) is [3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.02), (5-cyclohexyl-1,3,4-thiadiazol-2-yl)-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.04), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.05), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[(4R)-4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.06), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.07), 1-[4-[2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-3,4-dihydro-1H-isoquinolin-4-yl]-2-methyl-pyrazol-3-yl]ethenone (X.08), Methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate (X.09), [4-(5-chloro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2,4-difluorophenyl)isoxazol-3-yl]methanone (X.11), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(5-fluoro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.12), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[3,3-dimethyl-4-(1-methylpyrazol-4-yl)-1,4-dihydroisoquinolin-2-yl]methanone (X.13), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.14), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.16), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone (X.19), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.20), [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.21), or [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.22), or The compounds are selected from one of their (S)- or (R)-enantiomers as defined in Table X below.

[0092] [Table 2-1]

[0093] [Table 2-2]

[0094] [Table 2-3]

[0095] [Table 2-4]

[0096] In one embodiment, component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumide, isoflucipram, inpirfluxam, isofetamide, fluindapyr, cyclobutrifluram, fluoxastrobin, fenamidone, mandestrobin, picoxystrobin, pyraclostrobin, famoxadone, kresoxim-methyl, trifloxystrobin, azoxystrobin, methyltet Laprol, Amisulbrom, Cyazofamid, Fenpicoxamide, Florylpicoxamide, Methallylpicoxamide, Ametoctrazine, Fluazinam, Triphenyltin Hydroxide, Silthiofam, Fenpropimorph, Fenpropidin, Spiroxamine, Fenhexamid, Imazalil, Pyrisoxazole, Bromuconazole, Cyproconazole, Difenoconazole, Epoxiconazole, Flutriafol, Hexaconazole, Ipconazole, Metconazole, Myclobutanil, Penconazole, Propiconazole, Tebuconazole, Tetramethylpropional Conazole, triticonazole, prothioconazole, fluoxythioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, kasugamycin, mancozeb, copper fungicides, sulfur, zinc thiazole, captan, folpet, chlorothalonil, dithianon, quinoxyfen, proquinazide, fludioxonil, iprodione, procymidone, thiabendazole, zoxamide, metrafenone, fluopicolide, propamocarb, oxathiapiproline, Isopropyl oxapiprolin, acibenzolar-S-methyl, isotianil, phosphorous acid, cyflufenamid, tebufloquine, picarbutrazox, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-Oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro -quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-Dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(4-prop methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2-methyl methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate (these compounds can be prepared from the method described in WO 2020 / 193387), 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-hexyl-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-Difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), and aureobasidin A.

[0097] Preferably, component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumid, isoflucipram, inpirfluxam, fluindapyr, cyclobutrifluram, pyraclostrobin, trifloxystrobin, azoxystrobin, methyltetraprole, fenpicoxamide, florylpicoxamide, methallylpicoxamide, fluazinam, fenpropidin, fenhexamid, cipro Conazole, difenoconazole, metconazole, penconazole, propiconazole, tebuconazole, tetraconazole, prothioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, mancozeb, copper compounds (different salts), sulfur, folpet, chlorothalonil, dithianon, proquinazid, fludioxonil, metrafenone, oxathiapiprolin, fluoxapiprolin, acibenzolar-S-methyl, phosphorous acid, cyflu Phenamide, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-( trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]- N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide Ruboxamide, methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(4-propyltriazol-2-yl)phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl) )phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate (these compounds can be prepared from the method described in WO 2020 / 193387), 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-hexyl-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2, 2-Dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,The compound is selected from 2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), plant extract based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®), or aureobasidin A.

[0098] More preferably, component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazolinone thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), plant extract based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®), or aureobasidin A.

[0099] Even more preferably, component (B) is a compound selected from pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil or acibenzolar-S-methyl.

[0100] In one embodiment, component (B) is a compound selected from pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl.

[0101] In another embodiment, component (B) is a compound selected from TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), a plant extract based on an extract of Quillaja saponaria Molina (commercially available as BOTRISTOP®), or Aureobasidin A.

[0102] In another preferred embodiment, component (B) is a compound selected from pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil or acibenzolar-S-methyl, TAEGRO® (i.e. Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)) or aureobasidin A.

[0103] The compounds of component (B) are referred to herein above by their so-called "ISO common names" or other "common names" or trade names used in individual cases. The compounds of component (B) are known, commercially available, and / or can be synthesized using procedures known in the art and / or reported in the literature.

[0104] N-Methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-Dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-Methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]

[0033] 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, these compounds can be prepared from the methods described in WO 2017 / 055473, WO 2017 / 055469, WO 2017 / 093348 and WO 2017 / 118689.

[0105] Methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazole-2-yl]phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(4-propyltriazole-2-yl)phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate (these compounds can be prepared from the method described in WO 2020 / 079111), methyl (Z)-2-(5-cyclohexyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, these compounds can be prepared from the method described in WO 2020 / 193387.

[0106] N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[( 1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[( 3-Fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl] ]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, these compounds can be prepared from the method described in WO 2017 / 153380.

[0107] 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-hexyl-5-methyl-thiazole-4-carboxamide (these compounds are disclosed in the International Publication and WO 2017207362, WO 2019105933, and WO 2020109509), 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, Azole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]- N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide (these compounds can be prepared from the methods described in WO2017207362, WO2019105933, WO2020109511, WO2021244952).

[0108] As used herein, "TIMOREX Gold™" or "Timorex Gold®" refers to Melaleuca alternifolia oil, an extract of the tea tree plant, Melaleuca alternifolia, commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide.

[0109] TAEGRO™ or TAEGRO® as used herein refers to a microbial-based fungicide formulated as a wettable powder (13% w / w minimum 1 x 10 cfu / kg) containing 130 g / kg of Bacillus amyloliquefaciens strain FZB24 having accession number DSM 10271, commercially available as TAEGRO®.

[0110] BOTRISTOP®, as used herein, refers to a broad-spectrum biofungicide that is a plant extract based on an extract of Quillaja saponaria Molina.

[0111] As used herein, "REGALIA®" refers to a plant extract biofungicide (commercially available as REGALIA®) based on an extract of giant knotweed (Reynoutria sachalinensis) extract.

[0112] Aureobasidin A is an antifungal cyclic depsipeptide antibacterial agent produced by Aureobasidium pullulans. See, for example, Takesako et al., J. of Antibiot. 1991, 44, 919-924. WO 2018 / 102345 discloses the use of aureobasidin A as an agricultural fungicide for treating, preventing, or controlling fungal infections in plants and seeds.

[0113] According to another aspect of the present invention, there is provided a fungicidal composition comprising a mixture of components (A) and (B) as active ingredients, wherein component (A) is a compound of formula (IA) [ka] (In the formula, R 1 is methyl and R 2 is hydrogen, chlorine or methyl, and R 3 is hydrogen and R 4 is hydrogen or methyl, and R 5 and R 6 is hydrogen and R 7 is hydrogen, C1-C4 alkyl, or C3-C6 cycloalkyl, and R 8 is hydrogen and R 9 is hydrogen, bromine, chlorine, cyano, methyl or methoxy, B 1 is CH and B 2 is N or CR 11 and R 11 is hydrogen, and A is A1, A4, A7, A9 or A10 [ka] is selected from: [ka] indicates a bond to a C(=O) group, and the arrow indicates a bond to a Z 1 indicates a bond to the group, and Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing one heteroatom selected from N, and said phenyl and said 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents selected from fluorine. is a compound of the formula: Ingredient (B) is pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumide, isoflucipram, inpirfluxam, isofetamide, fluindapyr, cyclobutrifluram, fluoxastrobin, fenamidone, mandestrobin, picoxystrobin, pyraclostrobin, famoxadone, kresoxim-methyl, trifloxystrobin, azoxystrobin, methyltetraprole, Amisulbrom, cyazofamid, fenpicoxamide, florylpicoxamide, methallylpicoxamide, ametoctrazine, fluazinam, triphenyltin hydroxide, silthiofam, fenpropimorph, fenpropidin, spiroxamine, fenhexamid, imazalil, pyrisoxazole, bromuconazole, cyproconazole, difenoconazole, epoxiconazole, flutriafol, hexaconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, tebuconazole, tetraconazole fluoxetine, triticonazole, prothioconazole, fluoxythioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, kasugamycin, mancozeb, copper fungicides, sulfur, zinc thiazole, captan, folpet, chlorothalonil, dithianon, quinoxyfen, proquinazide, fludioxonil, iprodione, procymidone, thiabendazole, zoxamide, metrafenone, fluopicolide, propamocarb, oxathiapiproline, fluoxetine, fluoxetine, fluoxetine-1, fluoxetine-2, fluoxetine-3, fluoxetine-4, fluoxetine-5, fluoxetine-6, fluoxetine-7, fluoxetine-8, fluoxetine-9, fluoxetine-10, fluoxetine-11, fluoxetine-12, fluoxetine-13, fluoxetine-14, fluoxetine-15, fluoxetine-15, fluoxetine-16, fluoxetine-17, fluoxetine-18, fluoxetine-19, fluoxetine-20, fluoxetine-21, fluoxetine-22, fluoxetine-23, fluoxetine-24, fluoxetine-25, fluoxetine-26, fluoxetine-27, fluoxetine-28, fluoxetine-29 ... Xapiproline, acibenzolar-S-methyl, isotianil, phosphorous acid, cyflufenamid, tebufloquine, picarbutrazox, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-Oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro -quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-Dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, Methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, Methyl (Z)-3-methoxy-2-[2-methyl-5-(4- propyltriazol-2-yl)phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2 -methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-Dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), giant knotweed (Reynoutria sachalinensis) extract (commercially available as REGALIA®), a plant extract based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®), and aureobasidin A, with the proviso that the compound of formula (I) is not the following or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer, or N-oxide thereof:

[0114] [Table 3]

[0115] The PubChem Compound IDs assigned to the compounds excluded from the above claims refer to the identification numbers of each compound on the PubChem website (https: / / pubchem.ncbi.nlm.nih.gov / ).

[0116] Preferably, the fungicidal composition comprises a mixture of components (A) and (B) as active ingredients, wherein component (A) is a compound of formula (IA) [ka] (In the formula, R 1 is methyl and R 2 is hydrogen, chlorine or methyl, and R 3 is hydrogen and R 4 is hydrogen or methyl, and R 5 and R 6 is hydrogen and R 7 is hydrogen, C1-C4 alkyl, or C3-C6 cycloalkyl, and R 8 is hydrogen and R 9 is hydrogen, bromine, chlorine, cyano, methyl or methoxy, B 1 is CH and B 2 is N or CR 11 and R 11 is hydrogen, and A is A1, A4, A7, A9 or A10 [ka] is selected from: [ka] indicates a bond to a C(=O) group, and the arrow indicates a bond to a Z 1 indicates a bond to the group, and Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing one heteroatom selected from N, and said phenyl and said 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents selected from fluorine. is a compound of the formula: Ingredient (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazol-4-yl]benzol-4-methyl carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), a plant extract based on an extract of Quillaja saponaria Molina (commercially available as BOTRISTOP®), and Aureobasidin A, with the proviso that the compound of formula (I) is not the following or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer, or N-oxide thereof:

[0117] [Table 4]

[0118] The PubChem Compound IDs assigned to the compounds excluded from the above claims refer to the identification numbers of each compound on the PubChem website (https: / / pubchem.ncbi.nlm.nih.gov / ).

[0119] Enantiomerically pure final compounds can be obtained from racemic starting materials by standard physical separation techniques, such as reverse-phase chiral chromatography, if necessary, or by stereoselective synthesis techniques, for example, by using chiral starting materials.

[0120] The term "component A" refers to a compound of formula (I).

[0121] The following mixtures of component (A), which is a compound of formula (I), with component (B) as active ingredients are preferred (wherein the term "AX" refers to the compounds (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28), (X.29), (X.30), (X.31), (X.32), (X.33), (X.34), (X.35), (X.36), (X.37), (X.38), (X.39), (X.40), (X.41), (X.42), (X.43), (X.44), (X.45), (X.46), (X.47), (X.48), (X.49), (X.50), (X.51), (X.52), (X.53), (X.54), (X.55), (X.56), (X.57), (X.58), (X.59), (X.60), (X.61), (X.62), (X.63), (X.64), (X.65), (X.66), (X.67), (X.68), (X.69), (X.70), (X.71), (X.72), (X.73), (X.74), (X.75), (X.76), (X.77), (X.78), (X.7 (X.25), (X.26), (X.27), (X.28) or (X.29) means one ingredient (A) selected from: pydiflumetofen + AX, benzovindiflupyr + AX, bixafen + AX, fluxapyroxad + AX, isopyrazam + AX, penflufen + AX, penthiopyrad + AX, sedaxane + AX, boscalid + AX, fluopyram + AX, thifluzamide + AX, pyraziflumid + AX, isoflefluipram + AX, inpirfluxam + AX, isofetamide + AX, fluindapyr + AX, cyclobutrifluram + AX, fluo Xastrobin + AX, Fenamidone + AX, Mandestrobin + AX, Picoxystrobin + AX, Pyraclostrobin + AX, Famoxadone + AX, Kresoxim-methyl + AX, Trifloxystrobin + AX, Azoxystrobin + AX, Methyltetraprole + AX, Amisulbrom + AX, Cyazofamid + AX, Fenpicoxamide + AX, Florylpicoxamide + AX, Methallylpicoxamide + AX, Ametoctrazine + AX, Fluazinam + AX, Triphenyltin Hydroxide + AX, Silthiofam + AX, Fenpropimorph + AX X, fenpropidin + AX, spiroxamine + AX, fenhexamid + AX, imazalil + AX, pyrisoxazole + AX, bromuconazole + AX, cyproconazole + AX, difenoconazole + AX, epoxiconazole, flutriafol + AX, hexaconazole + AX, ipconazole + AX, metconazole + AX, myclobutanil + AX, penconazole + AX, propiconazole + AX, tebuconazole + AX, tetraconazole + AX, triticonazole + AX, prothioconazole + AX, fluoxythioconazole + AX,Mefentrifluconazole + AX, flufenoxadiazam + AX, ipflufenoquin + AX, quinofumelin + AX, metalaxyl-M + AX, cyprodinil + AX, pyrimethanil + AX, kasugamycin + AX, mancozeb + AX, copper fungicides + AX, sulfur + AX, zinc thiazole + AX, captan + AX, folpet + AX, chlorothalonil + AX, dithianon + AX, quinoxyfen + AX, proquinazide + AX, fludioxonil + AX, iprodione + AX, procymidone + AX, thiabendazole + AX, zoxamide + AX, Metrafenone + AX, Fluopicolide + AX, Propamocarb + AX, Oxathiapiprolin + AX, Fluoxapiprolin + AX, Acibenzolar-S-methyl + AX, Isotianil + AX, Phosphorous Acid + AX, Cyflufenamid + AX, Tebufloquine + AX, Picarburazox + AX, Tricyclazole + AX, N-Methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide + AX, N,2-Dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide + AX N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + AX, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide + AX, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea + AX, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea + AX, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + AX, N-[( 1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + AX, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide + AX, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide + AX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide + AX,N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide + AX, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide + AX, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide + AX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide + AX, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide + AX, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide + AX, Methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]fluoro]quinoline-3-carboxamide + AX phenoxy]prop-2-enoate + AX, methyl (Z)-3-methoxy-2-[2-methyl-5-(4-propyltriazol-2-yl)phenoxy]prop-2-enoate + AX, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate + AX, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate + AX, methyl (Z)-3-methoxy-2-[2- Methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate + AX, methyl (Z)-2-(5-cyclohexyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate + AX, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate + AX, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide + AX,2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-hexyl-5-methyl-thiazole-4-carboxamide + AX, 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbo 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24) + AX, Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)) + AX, Reynoutria sachalinensis extract (commercially available as REGALIA®) + AX,Plant extract based on extract of Quillaja saponaria Molina (commercially available as BOTRISTOP®) + AX ​​and Aureobasidin A + AX.

[0122] In another embodiment of the present invention, the following mixtures of component (A), which is a compound of formula (I), with component (B) as active ingredients are preferred (wherein the term "AX" refers to the compounds (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28), (X.29), (X.30), (X.31), (X.32), (X.33), (X.34), (X.35), (X.36), (X.37), (X.38), (X.39), (X.40), (X.41), (X.42), (X.43), (X.44), (X.45), (X.46), (X.47), (X.48), (X.49), (X.50), (X.51), (X.52), (X.53), (X.54), (X.55), (X.56), (X.57), (X.58), (X.59), (X.60), (X.61), (X.62), (X.63), (X.64), (X.65), (X.66), (X.67), (X.68), (X.69), (X.70), (X.71), (X.72), (X.73), (X.74), (X.75), (X.76), (X.77), (X (X.23), (X.24), (X.25), (X.26), (X.27), (X.28) or (X.29): pydiflumetofen + AX, benzovindiflupyr + AX, bixafen + AX, fluxapyroxad + AX, isopyrazam + AX, penflufen + AX, penthiopyrad + AX, sedaxane + AX, boscalid + AX, fluopyram + AX, thifluzamide + AX, pyraziflumid + AX, isoflecipram + AX, inpirfluxam + AX, isofetamide + AX, fluindapir + AX, sik Lobutrifluram + AX, Fluoxastrobin + AX, Fenamidone + AX, Mandestrobin + AX, Picoxystrobin + AX, Pyraclostrobin + AX, Famoxadone + AX, Kresoxim-methyl + AX, Trifloxystrobin + AX, Azoxystrobin + AX, Methyltetraprole + AX, Amisulbrom + AX, Cyazofamid + AX, Fenpicoxamide + AX, Florylpicoxamide + AX, Methallylpicoxamide + AX, Ametoctrazine + AX, Fluazinam + AX, Triphenyltin Hydroxide + AX, Silthiofam +AX, fenpropimorph +AX, fenpropidin +AX, spiroxamine +AX, fenhexamid +AX, imazalil +AX, pyrisoxazole +AX, bromuconazole +AX, cyproconazole +AX, difenoconazole +AX, epoxiconazole, flutriafol +AX, hexaconazole +AX, ipconazole +AX, metconazole +AX, myclobutanil +AX, penconazole +AX, propiconazole +AX, tebuconazole +AX, tetraconazole +AX, triticonazole +AX, prothioconazole +AX,Fluoxythioconazole + AX, Mefentrifluconazole + AX, Flufenoxadiazam + AX, Ipflufenoquin + AX, Quinofumelin + AX, Metalaxyl-M + AX, Cyprodinil + AX, Pyrimethanil + AX, Kasugamycin + AX, Mancozeb + AX, Copper fungicides + AX, Sulfur + AX, Zinc thiazole + AX, Captan + AX, Folpet + AX, Chlorothalonil + AX, Dithianon + AX, Quinoxyfen + AX, Proquinazide + AX, Fludioxonil + AX, Iprodione + AX, Procymidone + AX, Thiabendazole + AX, zoxamide + AX, metrafenone + AX, fluopicolide + AX, propamocarb + AX, oxathiapiprolin + AX, fluoxapiprolin + AX, acibenzolar-S-methyl + AX, isotianil + AX, phosphorous acid + AX, cyflufenamid + AX, tebufloquine + AX, picarbutrazox + AX, tricyclazole + AX, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide + AX, N,2-dimethoxy-N-[[4-[5- (Trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide + AX, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea + AX, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea + AX, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + AX, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + AX, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide + AX, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide + AX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide + AX,N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide + AX, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide + AX, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide + AX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide + AX, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide + AX, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide + AX, Methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]fluoro]quinoline-3-carboxamide + AX phenoxy]prop-2-enoate + AX, methyl (Z)-3-methoxy-2-[2-methyl-5-(4-propyltriazol-2-yl)phenoxy]prop-2-enoate + AX, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate + AX, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate + AX, methyl (Z)-3-methoxy-2-[2- Methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate + AX, methyl (Z)-2-(5-cyclohexyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate + AX, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate + AX, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide + AX,2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-hexyl-5-methyl-thiazole-4-carboxamide + AX, 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbo 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide + AX, TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24) + AX, Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)) + AX, Reynoutria sachalinensis extract (commercially available as REGALIA®),In the case of a plant extract based on an extract of Quillaja saponaria Molina (commercially available as BOTRISTOP®) and aureobasidin A+AX, the weight ratio of component (A) to component (B) is 100:1 to 1:40, preferably 40:1 to 1:40, even more preferably 20:1 to 1:20, even more preferably 15:1 to 1:30, even more preferably 10:1 to 1:10, most preferably 5:1 to 1:5, and even most preferably 2:1 to 1:2.

[0123] In another embodiment of the present invention, the following mixtures of component (A), which is a compound of formula (I), with component (B) as active ingredients are preferred (wherein the term "AX" refers to the compounds (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28), (X.29), (X.30), (X.31), (X.32), (X.33), (X.34), (X.35), (X.36), (X.37), (X.38), (X.39), (X.40), (X.41), (X.42), (X.43), (X.44), (X.45), (X.46), (X.47), (X.48), (X.49), (X.50), (X.51), (X.52), (X.53), (X.54), (X.55), (X.56), (X.57), (X.58), (X.59), (X.60), (X.61), (X.62), (X.63), (X.64), (X.65), (X.66), (X.67), (X.68), (X.69), (X.70), (X.71), (X.72), (X.73), (X.74), (X.75), (X.76), (X.77), (X (X.3), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28) or (X.29): TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24) + AX, Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)) + AX, Reynoutria sachalinensis extract (commercially available as REGALIA®) + AX, plant extract based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®) + AX ​​or Aureobasidin A + AX.

[0124] In another embodiment of the present invention, the following mixtures of component (A), which is a compound of formula (I), with component (B) as active ingredients are preferred (wherein the term "AX" refers to the compounds (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28), (X.29), (X.30), (X.31), (X.32), (X.33), (X.34), (X.35), (X.36), (X.37), (X.38), (X.39), (X.40), (X.41), (X.42), (X.43), (X.44), (X.45), (X.46), (X.47), (X.48), (X.49), (X.50), (X.51), (X.52), (X.53), (X.54), (X.55), (X.56), (X.57), (X.58), (X.59), (X.60), (X.61), (X.62), (X.63), (X.64), (X.65), (X.66), (X.67), (X.68), (X.69), (X.70), (X.71), (X.72), (X.73), (X.74), (X.75), (X.76), (X.77), (X (X.3), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28) or (X.29): TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24) + AX, Melaleuca alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)) + AX, Reynoutria sachalinensis extract (commercially available as REGALIA®) + AX, plant extract based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®) + AX ​​or Aureobasidin A + AX, the weight ratio of component (A) to component (B) being 100:1 to 1:40.

[0125] In another preferred embodiment of the present invention, the following mixtures of component (A), which is a compound of formula (I), with component (B) as active ingredients are preferred (wherein the term "AX" refers to the compounds (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28), (X.29), (X.30), (X.31), (X.32), (X.33), (X.34), (X.35), (X.36), (X.37), (X.38), (X.39), (X.40), (X.41), (X.42), (X.43), (X.44), (X.45), (X.46), (X.47), (X.48), (X.49), (X.50), (X.51), (X.52), (X.53), (X.54), (X.55), (X.56), (X.57), (X.58), (X.59), (X.60), (X.61), (X.62), (X.63), (X.64), (X.65), (X.66), (X.67), (X.68), (X.69), (X.70), (X.71), (X.72), (X.73), (X.74), (X.75), (X.76), (X.77), ( (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28) or (X.29): TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24) + AX, Melaleuca alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)) + AX, Reynoutria sachalinensis extract (commercially available as REGALIA®) + AX, Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®) + AX, or Aureobasidin A + AX, wherein the weight ratio of component (A) to component (B) is 40:1 to 1:40.

[0126] In another more preferred embodiment of the present invention, the following mixtures of component (A), which is a compound of formula (I), with component (B) as active ingredients are preferred (wherein the term "AX" refers to the compounds (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28), (X.29), (X.30), (X.31), (X.32), (X.33), (X.34), (X.35), (X.36), (X.37), (X.38), (X.39), (X.40), (X.41), (X.42), (X.43), (X.44), (X.45), (X.46), (X.47), (X.48), (X.49), (X.50), (X.51), (X.52), (X.53), (X.54), (X.55), (X.56), (X.57), (X.58), (X.59), (X.60), (X.61), (X.62), (X.63), (X.64), (X.65), (X.66), (X.67), (X.68), (X.69), (X.70), (X.71), (X.72), (X.73), (X.74), (X.75), (X.76), (X.77), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28) or (X.29): TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24) + AX, Melaleuca alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)) + AX, Reynoutria sachalinensis extract (commercially available as REGALIA®) + AX, Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®) + AX, or Aureobasidin A + AX, the weight ratio of component (A) to component (B) being 40:1 to 1:20.

[0127] In another even more preferred embodiment of the present invention, the following mixtures of component (A), which is a compound of formula (I), with component (B) as active ingredients are preferred (wherein the term "AX" refers to the compounds (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12) listed in Table X according to the present invention, (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28) or (X.29)): TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24) + AX, Melaleuca alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)) + AX, Reynoutria sachalinensis extract (commercially available as REGALIA®) + AX, Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®) + AX, or Aureobasidin A + AX, wherein the weight ratio of component (A) to component (B) is 20:1 to 1:20.

[0128] In an even more preferred embodiment of the present invention, the following mixtures of component (A), which is a compound of formula (I), with component (B) as active ingredients are preferred (wherein the term "AX" means one component (A) selected from compounds (X.02), (X.04), (X.05), (X.06), (X.07), (X.08), (X.09), (X.11), (X.12), (X.13), (X.14), (X.16), (X.19), (X.20), (X.21) or (X.22) listed in Table X according to the present invention): TAEGRO® (i.e. Bacillus amyloliquefaciens strain FZB24) + AX, Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)) + AX, giant knotweed (Reynoutria sachalinensis) extract (commercially available as REGALIA®) + AX, plant extract based on Quillaja (Quillaja saponaria Molina) extract (commercially available as BOTRISTOP®) + AX ​​or aureobasidin A + AX, the weight ratio of component (A) to component (B) being 20:1 to 1:20.

[0129] In another even more preferred embodiment of the present invention, component (A) is compound number X.05 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof, and component (B) is selected from the group consisting of TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria knotweed ( sachalinensis extract (commercially available under the trademark REGALIA®), a plant extract based on an extract of Quillaja saponaria Molina (commercially available under the trademark BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 40:1 to 1:40, preferably 20:1 to 1:20. In a preferred embodiment, the composition comprises a stereoisomer of X.05, wherein a methyl group (R 7 The (1-methylpyrazol-4-yl) groups have a syn-relationship to each other. Preferably, the composition comprises the (1S,4S)-enantiomer of compound X.05, or a salt or N-oxide thereof. Alternatively, in another embodiment, the composition comprises the (1R,4R)-enantiomer of compound X.05, or a salt or N-oxide thereof.

[0130] In another even more preferred embodiment of the present invention, component (A) is compound number X.09 methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate or a salt, enantiomer, tautomer, or N-oxide thereof, and component (B) is selected from the group consisting of TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria knotweed ( sachalinensis extract (commercially available under the trademark REGALIA®), a plant extract based on an extract of Quillaja saponaria Molina (commercially available under the trademark BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 40:1 to 1:40, preferably 20:1 to 1:20. In a preferred embodiment, the composition comprises a stereoisomer of X.09, wherein the carboxylate group (R 7 The (1-methylpyrazol-4-yl) and (1-methylpyrazol-4-yl) groups have a syn-relationship to each other. Preferably, the composition comprises the (1S,4S)-enantiomer of compound X.09, or a salt or N-oxide thereof. Alternatively, in another embodiment, the composition comprises the (1R,4R)-enantiomer of compound X.09, or a salt or N-oxide thereof.

[0131] In another even more preferred embodiment of the present invention, component (A) is compound number X.16 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof, and component (B) is selected from the group consisting of TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria knotweed ( sachalinensis extract (commercially available under the trademark REGALIA®), a plant extract based on an extract of Quillaja saponaria Molina (commercially available under the trademark BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 40:1 to 1:40, preferably 20:1 to 1:20.

[0132] In another even more preferred embodiment of the present invention, component (A) is compound number X.21 [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof, and component (B) is selected from the group consisting of TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria knotweed ( sachalinensis extract (commercially available under the trademark REGALIA®), a plant extract based on an extract of Quillaja saponaria Molina (commercially available under the trademark BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 40:1 to 1:40, preferably 20:1 to 1:20. In a preferred embodiment, the composition comprises a stereoisomer of X.21, wherein the methyl group (R 7 The (1,5-dimethylpyrazol-4-yl) groups have a syn-relationship to each other. Preferably, the composition comprises the (1S,4S)-enantiomer of compound X.21 or a salt or N-oxide thereof. Alternatively, in another embodiment, the composition comprises the (1R,4R)-enantiomer of compound X.21 or a salt or N-oxide thereof.

[0133] In another even more preferred embodiment of the present invention, component (A) is compound number X.22 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof, and component (B) is selected from the group consisting of TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria knotweed ( sachalinensis extract (commercially available under the trademark REGALIA®), a plant extract based on an extract of Quillaja saponaria Molina (commercially available under the trademark BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 40:1 to 1:40, preferably 20:1 to 1:20. In a preferred embodiment, the composition comprises the stereoisomer of X.22, which has a methyl group (R 7 The (1-methylpyrazol-4-yl) and (1-methylpyrazol-4-yl) groups have a syn-relationship to each other. Preferably, the composition comprises the (1S,4S)-enantiomer of compound X.22, or a salt or N-oxide thereof. Alternatively, in another embodiment, the composition comprises the (1R,4R)-enantiomer of compound X.22, or a salt or N-oxide thereof.

[0134] In a preferred composition according to the present invention, component (A) is compound number X.02 [3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole. , mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0135] In another preferred composition according to the present invention, component (A) is compound number X.04 (5-cyclohexyl-1,3,4-thiadiazol-2-yl)-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefenoconazole, or benzovindiflupyr. Ntrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0136] In another preferred composition according to the present invention, component (A) is compound number X.05 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothiazolinone ... Oconazole, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0137] In another preferred composition according to the present invention, component (A) is compound number X.06 [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[(4R)-4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, ol, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0138] In another preferred composition according to the present invention, component (A) is compound number X.07 [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0139] In another preferred composition according to the present invention, component (A) is compound number X.08 1-[4-[2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-3,4-dihydro-1H-isoquinolin-4-yl]-2-methyl-pyrazol-3-yl]ethenon or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0140] In another preferred composition according to the present invention, component (A) is compound number X.09 methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0141] In another preferred composition according to the invention, component (A) is compound number X.11 [4-(5-chloro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2,4-difluorophenyl)isoxazol-3-yl]methanone 3 or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0142] In another preferred composition according to the present invention, component (A) is compound number X.12 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(5-fluoro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0143] In another preferred composition according to the present invention, component (A) is compound number X.13 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[3,3-dimethyl-4-(1-methylpyrazol-4-yl)-1,4-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, methanol ... Fentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0144] In another preferred composition according to the present invention, component (A) is compound number X.14 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefenoconazole, or benzovindiflupyr. Ntrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0145] In another preferred composition according to the present invention, component (A) is compound number X.16 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefenazole ... Entrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0146] In another preferred composition according to the present invention, component (A) is compound number X.19 [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentri Fluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0147] In another preferred composition according to the present invention, component (A) is compound number X.20 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefen Trifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0148] In another preferred composition according to the present invention, component (A) is compound number X.21 [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, promethazine, benzophenone ... Tioconazole, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0149] In another preferred composition according to the present invention, component (A) is compound number X.22 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, ol, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 15:1 to 1:30.

[0150] In an even more preferred composition according to the present invention, component (A) is compound number X.02 [3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole. , mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0151] In another even more preferred composition according to the present invention, component (A) is compound number X.04 (5-cyclohexyl-1,3,4-thiadiazol-2-yl)-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefenoconazole, or benzovindiflupyr. Ntrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0152] In another even more preferred composition according to the present invention, component (A) is compound number X.05 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothiazolinone ... Oconazole, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0153] In another even more preferred composition according to the present invention, component (A) is compound number X.06 [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[(4R)-4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, ol, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0154] In another even more preferred composition according to the present invention, component (A) is compound number X.07 [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0155] In another even more preferred composition according to the present invention, component (A) is compound number X.08 1-[4-[2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-3,4-dihydro-1H-isoquinolin-4-yl]-2-methyl-pyrazol-3-yl]ethenon or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0156] In another even more preferred composition according to the present invention, component (A) is compound number X.09 methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0157] In another even more preferred composition according to the present invention, component (A) is compound number X.11 [4-(5-chloro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2,4-difluorophenyl)isoxazol-3-yl]methanone 3 or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0158] In another even more preferred composition according to the present invention, component (A) is compound number X.12 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(5-fluoro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, Mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0159] In another even more preferred composition according to the present invention, component (A) is compound number X.13 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[3,3-dimethyl-4-(1-methylpyrazol-4-yl)-1,4-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, methanone ... Fentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0160] In another even more preferred composition according to the present invention, component (A) is compound number X.14 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefenoconazole ... Ntrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0161] In another even more preferred composition according to the present invention, component (A) is compound number X.16 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefenazole ... Entrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0162] In another even more preferred composition according to the present invention, component (A) is compound number X.19 [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentri Fluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0163] In another even more preferred composition according to the present invention, component (A) is compound number X.20 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefen Trifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0164] In another even more preferred composition according to the present invention, component (A) is compound number X.21 [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, promethanone ... Tioconazole, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0165] In another even more preferred composition according to the present invention, component (A) is compound number X.22 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, and component (B) is pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, ol, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), or aureobasidin A, wherein the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0166] In the most preferred compositions according to the present invention, component (A) is compound No. X.02 [3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0167] In another most preferred composition according to the present invention, component (A) is compound No. X.04 (5-cyclohexyl-1,3,4-thiadiazol-2-yl)-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0168] In another most preferred composition according to the present invention, component (A) is compound No. X.05 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0169] In another most preferred composition according to the present invention, component (A) is compound No. X.06 [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[(4R)-4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0170] In another most preferred composition according to the present invention, component (A) is compound No. X.07 [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0171] In another most preferred composition according to the present invention, component (A) is compound number X.08 1-[4-[2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-3,4-dihydro-1H-isoquinolin-4-yl]-2-methyl-pyrazol-3-yl]ethenone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0172] In another most preferred composition according to the present invention, component (A) is compound No. X.09 methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is from 10:1 to 1:10 (or even more preferably from 5:1 to 1:5).

[0173] In another most preferred composition according to the present invention, component (A) is compound No. X.11 [4-(5-chloro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2,4-difluorophenyl)isoxazol-3-yl]methanone 3 or a salt, enantiomer, tautomer or N-oxide thereof, component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil or acibenzolar-S-methyl, and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0174] In another most preferred composition according to the present invention, component (A) is compound No. X.12 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(5-fluoro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil or acibenzolar-S-methyl, and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0175] In another most preferred composition according to the present invention, component (A) is compound No. X.13 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[3,3-dimethyl-4-(1-methylpyrazol-4-yl)-1,4-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof, component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl, and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0176] In another most preferred composition according to the present invention, component (A) is compound No. X.14 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof, component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl, and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0177] In another most preferred composition according to the present invention, component (A) is compound No. X.16 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof, component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil or acibenzolar-S-methyl, and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0178] In another most preferred composition according to the present invention, component (A) is compound No. X.19 [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone or a salt, enantiomer, tautomer, or N-oxide thereof, component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl, and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0179] In another most preferred composition according to the present invention, component (A) is compound No. X.20 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0180] In another most preferred composition according to the present invention, component (A) is compound No. X.21 [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0181] In another most preferred composition according to the present invention, component (A) is compound No. X.22 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5).

[0182] In yet another most preferred composition according to the present invention, component (A) is compound No. X.05, [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5). In a preferred embodiment, the composition comprises a stereoisomer of X.05, which is a methyl group (R 7 The (1-methylpyrazol-4-yl) groups have a syn-relationship to each other. Preferably, the composition comprises the (1S,4S)-enantiomer of compound X.05, or a salt or N-oxide thereof. Alternatively, in another embodiment, the composition comprises the (1R,4R)-enantiomer of compound X.05, or a salt or N-oxide thereof.

[0183] In another most preferred composition according to the present invention, component (A) is compound number X.09, methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate, or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5). In a preferred embodiment, the composition comprises a stereoisomer of X.09, wherein the carboxylate group (R 7), wherein the (1-methylpyrazol-4-yl) groups have a syn-relationship to each other. Preferably, the composition comprises the (1S,4S)-enantiomer of compound X.09, or a salt or N-oxide thereof. Alternatively, in another embodiment, the composition comprises the (1R,4R)-enantiomer of compound X.09, or a salt or N-oxide thereof.

[0184] In yet another most preferred composition according to the present invention, component (A) is compound No. X.21 [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone or a salt, enantiomer, tautomer or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is from 10:1 to 1:10 (or even more preferably from 5:1 to 1:5). In a preferred embodiment, the composition comprises a stereoisomer of X.21, which is a methyl group (R 7 The (1,5-dimethylpyrazol-4-yl) groups have a syn-relationship to each other. Preferably, the composition comprises the (1S,4S)-enantiomer of compound X.21 or a salt or N-oxide thereof. Alternatively, in another embodiment, the composition comprises the (1R,4R)-enantiomer of compound X.21 or a salt or N-oxide thereof.

[0185] In yet another most preferred composition according to the present invention, component (A) is compound No. X.22 [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone or a salt, enantiomer, tautomer, or N-oxide thereof; component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, or acibenzolar-S-methyl; and the weight ratio of component (A) to component (B) is 10:1 to 1:10 (or even more preferably 5:1 to 1:5). In a preferred embodiment, the composition comprises a stereoisomer of X.22, which is a methyl group (R 7 The (1-methylpyrazol-4-yl) and (1-methylpyrazol-4-yl) groups have a syn-relationship to each other. Preferably, the composition comprises the (1S,4S)-enantiomer of compound X.22, or a salt or N-oxide thereof. Alternatively, in another embodiment, the composition comprises the (1R,4R)-enantiomer of compound X.22, or a salt or N-oxide thereof.

[0186] The term "compound of formula (I)" refers to component A.

[0187] In any of the compositions according to the invention, the composition may contain a further active ingredient (C) different from component (B), such as pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumid, isoflucipram, inpirfluxam, isofetamide, fluindapyr, cyclobutrifluram, fluoxastrobin, fenamidone, mandestrobin, picoxystrobin, pyraclostrobin, famoxa Don, kresoxim-methyl, trifloxystrobin, azoxystrobin, methyltetraprole, amisulbrom, cyazofamid, fenpicoxamide, florylpicoxamide, methallylpicoxamide, ametoctrazine, fluazinam, triphenyltin hydroxide, silthiofam, fenpropimorph, fenpropidin, spiroxamine, fenhexamid, imazalil, pyrisoxazole, bromuconazole, cyproconazole, difenoconazole, epoxiconazole, flutriafol, hexaconazole, i Puconazole, metconazole, myclobutanil, penconazole, propiconazole, tebuconazole, tetraconazole, triticonazole, prothioconazole, fluoxythioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, kasugamycin, mancozeb, copper fungicides, sulfur, zinc thiazole, captan, folpet, chlorothalonil, dithianon, quinoxyfen, proquinazide, fludioxonil, iprodi on, procymidone, thiabendazole, zoxamide, metrafenone, fluopicolide, propamocarb, oxathiapiprolin, fluoxapiprolin, acibenzolar-S-methyl, isotianil, phosphorous acid, cyflufenamid, tebufloquine, picarbutrazox, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-Oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl -3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1- [(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-Dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, Methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, Methyl (Z)-3-methoxy-2-[2-methyl-5-(4- propyltriazol-2-yl)phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2 -methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-Dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia The composition may contain a further active ingredient (C) selected from the group consisting of an extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide), an extract of Reynoutria sachalinensis (commercially available as REGALIA®), a plant extract based on an extract of Quillaja saponaria Molina (commercially available as BOTRISTOP®), and aureobasidin A.

[0188] Preferably, the component (C) different from the component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumid, isoflucipram, inpirfluxam, fluindapyr, cyclobutrifluram, pyraclostrobin, trifloxystrobin, azoxystrobin, methyltetraprole, fenpicoxamide, florylpicoxamide, methallylpicoxamide, fluazinam, fenpropizin, fenhexyl Samidi, cyproconazole, difenoconazole, metconazole, penconazole, propiconazole, tebuconazole, tetraconazole, prothioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, mancozeb, copper compounds (different salts), sulfur, folpet, chlorothalonil, dithianon, proquinazid, fludioxonil, metrafenone, oxathiapiprolin, fluoxapiprolin, acibenzolar-S-methyl, phosphatidylcholine Acid, cyflufenamid, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5 -(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]- N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide Ruboxamide, methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(4-propyltriazol-2-yl)phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl) )phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate (these compounds can be prepared from the method described in WO 2020 / 193387), 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-hexyl-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2, 2-Dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,A compound selected from the group consisting of 2-dimethylcyclobutyl-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), and Aureobasidin A.

[0189] Even more preferably, component (C) different from component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl -thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24), melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), plant extract based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®), and aureobasidin A.

[0190] In another embodiment of the present invention, there is provided a fungicidal composition comprising a mixture of component (A) as an active ingredient, and component (B), and component (C), wherein component (A) is any of the compounds (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24) listed in Table X according to the present invention. , (X.25), (X.26), (X.27), (X.28) or (X.29), wherein component (C) and component (B) are selected from pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumid, isofulcipram, inpirfluxam, isofetamide, fluindapyr, cyclobutrifluram, fluoxastrobin, fenamidone, mandestrobin, picoxystrobin, pirac Rostrobin, famoxadone, kresoxim-methyl, trifloxystrobin, azoxystrobin, methyltetraprole, amisulbrom, cyazofamid, fenpicoxamide, florylpicoxamide, methallylpicoxamide, ametoctrazine, fluazinam, triphenyltin hydroxide, silthiofam, fenpropimorph, fenpropidin, spiroxamine, fenhexamid, imazalil, pyrisoxazole, bromuconazole, cyproconazole, difenoconazole, epoxiconazole, flutriafol, hexaconazole, Ipconazole, metconazole, myclobutanil, penconazole, propiconazole, tebuconazole, tetraconazole, triticonazole, prothioconazole, fluoxythioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, kasugamycin, mancozeb, copper fungicides, sulfur, zinc thiazole, captan, folpet, chlorothalonil, dithianon, quinoxyfen, proquinazide, fludioxonil, iprodione, procymidone,Thiabendazole, zoxamide, metrafenone, fluopicolide, propamocarb, oxathiapiprolin, fluoxapiprolin, acibenzolar-S-methyl, isotianil, phosphorous acid, cyflufenamid, tebufloquine, picarbutrazox, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, 1-Methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro- Quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide,N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(4-propyltriazol-2-yl)phenoxy]prop-2-enoate, Methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl ( Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-hexyl-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide,2-[(2,6-Difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia A fungicidal composition is provided, wherein components (B) and (C) are compounds selected from the group consisting of (a) extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide), (b) extract of Reynoutria sachalinensis (commercially available as REGALIA®), (c) extract of Quillaja saponaria Molina (commercially available as BOTRISTOP®), and (d) extract of aureobasidin A, and components (B) and (C) are not the same compound.

[0191] Preferably, the fungicidal composition comprises a mixture of component (A) as an active ingredient, and component (B) and component (C), wherein component (A) is a compound (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24) listed in Table X according to the present invention. , (X.25), (X.26), (X.27), (X.28) or (X.29), and wherein component (C) and component (B) are selected from pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumide, isoflucipram, inpirfluxam, fluindapyr, cyclobutrifluram, pyraclostrobin, trifloxystrobin, azoxystrobin, methyltetraprole, fenpicoxa fluazinam, fenpropidin, fenhexamid, cyproconazole, difenoconazole, metconazole, penconazole, propiconazole, tebuconazole, tetraconazole, prothioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, mancozeb, copper compounds (different salts), sulfur, folpet, chlorothalonil, dithianon, proquinazide, fludioxonil ... Trafenone, oxathiapiprolin, fluoxapiprolin, acibenzolar-S-methyl, phosphorous acid, cyflufenamid, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-Oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro -quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-Dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(4-prop methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2-methyl methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate (these compounds can be prepared from the method described in WO 2020 / 193387), 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-hexyl-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-Difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), plant extract based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®), and aureobasidin A, wherein components (B) and (C) are not the same compound.

[0192] More preferably, it is a fungicidal composition comprising a mixture of component (A) as an active ingredient, and component (B), and component (C), wherein component (A) is selected from the group consisting of compounds (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28) or (X.29) listed in Table X according to the present invention. The compound of formula (I) selected, wherein component (C) and component (B) are pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia A fungicidal composition is provided in which components (B) and (C) are compounds selected from the group consisting of (a) extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide), (b) extract of Reynoutria sachalinensis (commercially available as REGALIA®), (c) extract of Quillaja saponaria Molina (commercially available as BOTRISTOP®), and (d) aureobasidin A, and components (B) and (C) are not the same compound.

[0193] The component (C) compounds are referred to herein and above by so-called "ISO common names" or other "common names" used in individual cases or trade names. The component (C) compounds are known, commercially available, and / or can be synthesized using procedures known in the art and / or reported in the literature, such as those set forth above.

[0194] Components (B) and (C) combined with component (A) can enhance the latter's effectiveness against fungi, and vice versa. Furthermore, the fungicidal composition may be effective against a broader range of fungal pathogens than the individual active ingredients can combat when used alone. Generally, the weight ratio of component (A) to the mixture of components (B) and (C) can be 100:1 to 1:100, or 50:1 to 1:50, or 20:1 to 1:20, or 10:1 to 1:10, or 5:1 to 1:5. otherwise, the weight ratio of component (A) to the mixture of components (B) and (C) is from 2:1 to 1:2, or from 4:1 to 2:1, or 1:1, or 5:1, or 5:2, or 5:3, or 5:4, or 4:1, or 4:2, or 4:3, or 3:1, or 3:2, or 2:1, or 1:5, or 2:5, or 3:5, or 4:5, or 1:4, or 2:4, or 3:4, or The mixing ratios may be 1:3, or 2:3, or 1:2, or 1:600, or 1:300, or 1:150, or 1:35, or 2:35, or 4:35, or 1:75, or 2:75, or 4:75, or 1:6000, or 1:3000, or 1:1500, or 1:350, or 2:350, or 4:350, or 1:750, or 2:750, or 4:750. These mixing ratios are understood to include, on the one hand, weight ratios and, on the other hand, molar ratios.

[0195] In embodiments of the invention in which the composition comprises component (A), component (B), and component (C), the weight ratio of component (A) to the sum of components (B) and (C) can be from 100:1 to 1:100, preferably from 50:1 to 1:50, more preferably from 20:1 to 1:40, even more preferably from 15:1 to 1:30, even more preferably from 12:1 to 1:25, or from 10:1 to 1:20, or from 10:1 to 1:10, or from 5:1 to 1:15, or from 5:1 to 1:5, or from 4:1 to 1:4, or from 3:1 to 1:10, or from 3:1 to 1:3, or from 2:1 to 1:5, or from 1:1.

[0196] Compounds of formula (I) according to the present invention can be formed as shown in the following schemes, where, unless otherwise specified, the definition of each variable is as defined above for compounds of formula (I).

[0197] Compounds of formula (I) according to the present invention can be formed as shown in Schemes 1-20 below, where, unless otherwise specified, the definition of each variable is as defined above for compounds of formula (I).

[0198] In particular, R 4 and R 6 is hydrogen, and R 5 Compounds of formula (I), wherein is hydrogen or methyl, can be formed as shown in Schemes 1-7 below, where, unless otherwise specified, the definition of each variable is as defined above for compounds of formula (I).

[0199] In any of the following schemes, the possible presence of one or more asymmetric carbon atoms in the compounds of formula (I) according to the invention means that the compounds can occur in chiral isomeric, i.e. enantiomeric or diastereomeric forms.

[0200] The compound of formula (I) can be prepared by a person skilled in the art according to known methods. More specifically, the compound of formula (I) can be prepared by reacting a compound of formula (III) or a salt thereof (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I)) to compounds of formula (II) 1 , A 2 , A 3 can be prepared by reaction of a compound of formula (I) with a carboxylic acid, which is as defined for the compound of formula (I). This reaction is shown in Scheme 1. [ka] Scheme 1

[0201] In Scheme 1, a compound of formula (II) 1 , A 2 , A 3 and Z 1 is as defined for compounds of formula (I), can be activated to compounds of formula (IIa) by methods known to those skilled in the art and described, for example, in Tetrahedron 2005, 61(46), 10827-10852. For example, compounds of formula (IIa) (wherein X 0 Compounds of formula (IIa) are formed by treating compounds of formula (II) with, for example, oxalyl chloride or thionyl chloride in the presence of a catalytic amount of N,N-dimethylformamide (DMF) in an inert solvent such as methylene dichloride or tetrahydrofuran (THF) at temperatures between 20°C and 100°C, preferably 25°C. Compounds of formula (IIa) are formed by treating compounds of formula (III) (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), optionally in the presence of a base such as triethylamine or pyridine, to yield compounds of formula (I). Alternatively, compounds of formula (I) may be prepared by treatment of compounds of formula (II) with dicyclohexylcarbodiimide (DCC), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) or 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU) in an inert solvent such as pyridine, DMF, acetonitrile, CHCl or THF, optionally in the presence of a base such as triethylamine, at a temperature between 30° C. and 180° C. to yield activated compounds of formula (IIa), where X 0 is obtained by reacting G 1 , G 2 or G 3Finally, compounds of formula (II) can be activated by reaction with a coupling reagent such as propanephosphonic anhydride (T3P), as described, for example, in Synthesis 2013, 45, 1569, to give compounds of formula (IIa), where X 0 is obtained by reacting G 4 Further reaction of the compound of formula (III) with an amine (or a salt thereof) provides the compound of formula (I). [ka] Scheme 1a

[0202] The compound of formula (II) can be converted by ester hydrolysis to a compound of formula (IIb) (wherein A 1 , A 2 , A 3 is N and Z 1 is as described in formula (I), and R 0 is a C1-C4 alkyl). Various conditions can be used, such as aqueous sodium hydroxide or lithium hydroxide and a water-miscible organic solvent such as THF, dimethoxyethane, methanol, or ethanol. Such ester hydrolysis is well known to those skilled in the art. Compounds of formula (IIb) can also be directly converted to compounds of formula (I) by reacting compounds of formula (IIb) with compounds of formula (III) in the presence of trimethylaluminum or trimethylaluminum-DABCO complex in an inert solvent such as toluene or methylene chloride. Such reactions have been reported in the literature (see Tetrahedron Lett. 1977, 4171-4174, Tetrahedron Lett. 2006, 5767-5769 and references cited therein). Compounds of formula (II) and (IIb) are commercially available or can be synthesized as described below.

[0203] For example, a compound of formula (IIIa) 4 and R 6 is hydrogen and R 5is hydrogen or methyl, and R 1 , R 2 , R 3 , R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I)) can be prepared by reacting a compound of formula (IVa) 4 and R 6 is hydrogen and R 5 is hydrogen or methyl, and R 1 , R 2 , R 3 , R 7 , R 8 , R 9 , B 1 and B 2 can be prepared from compounds of formula (I) (as defined for compounds of formula (I)) by treatment with a reducing agent such as NaBHCN and an acid such as hydrochloric acid or acetic acid in a protic solvent such as methanol or ethanol. Such reactions are well known in the literature, and similar reactions are described, for example, in Deng, Zeping et al., China Patent No. 103772278 and Synthesis 1979, 4, 281-283. Alternatively, compounds of formula (IIIa) can be prepared from compounds of formula (IVa) by reduction with hydrogen in the presence of a suitable metal catalyst such as Pd, Ir, or Rh, with a suitable ligand, for example, a diphosphine [1,2-bis(diphenylphosphino)ethane (dppe), 1,3-bis(diphenylphosphino)propane (dppp), or 1,4-bis(diphenylphosphino)butane (dppb)]. A similar reaction is reported, for example, in React. Kinet. Cat. Lett. 2007, 92, 99-104. This reaction is shown in Scheme 2. [ka] Scheme 2

[0204] As shown in Scheme 3, a compound of formula (IIIb) 4 , R 6 and R 7is hydrogen and R 5 is hydrogen or methyl, and R 1 , R 2 , R 3 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), can be prepared by the synthesis of compounds of formula (VI) (wherein X 0 is a leaving group such as a halogen, and R 0 is C1-C6 alkyl) to give a compound of formula (V), 4 , R 6 and R 7 is hydrogen and R 5 is hydrogen or methyl, and R 1 , R 2 , R 3 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I). Alternatively, compounds of formula (V) can be converted to compounds of formula (R 0 CO)2O(wherein, R 0 is a C1-C6 alkyl) in an inert solvent such as methylene chloride, THF or 2-methyl-THF, optionally in the presence of a base such as triethylamine or dimethylaminopyridine, at temperatures between 0°C and 60°C. Compounds of formula (V) are then metallated with a base, for example an alkyl metal base such as tert-butyllithium, and an additive such as N,N,N',N'-tetramethylethylenediamine (TMEDA), in an inert polar solvent such as THF or 2-methyl-THF, at low temperatures, for example -78°C to room temperature. 7 -X 0 an electrophile of formula X 0 is as already defined, and R 7is C1-C4 alkyl, C1-C4 alkylcarbonyl, C1-C4 alkoxycarbonyl, N-methoxy-N-methyl-carbonyl, C1-C4 alkylaminocarbonyl, di(C1-C4 alkylamino)carbonyl or C3-C6 cycloalkyl, where C3-C6 cycloalkyl may be optionally substituted with one, two or three substituents independently selected from halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl and C1-C4 alkoxy, to give a compound of formula (Va), where R 4 and R 6 is hydrogen and R 5 is hydrogen or methyl, and R 0 is a C1-C6 alkyl, and R 1 , R 2 , R 3 , R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), to give: This reaction is shown in Scheme 3. [ka] Scheme 3

[0205] Compounds of formula (Va) can be prepared by methods known to those skilled in the art from compounds of formula (IIIa) (wherein R 4 and R 6 is hydrogen and R 5 is hydrogen or methyl, and R 1 , R 2 , R 3 , R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I). For example, a compound of formula (Va) 0(wherein is tert-butyl) can be treated with an organic or inorganic acid such as trifluoroacetic acid or HCl to provide a compound of formula (IIIa). This reaction is shown in Scheme 4. [ka] Scheme 4

[0206] A compound of formula (IVa) 4 and R 6 is hydrogen and R 5 is hydrogen or methyl, and R 1 , R 2 , R 3 , R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), can be converted to compounds of formula (VIII), where R 1 , R 2 and R 3 is as defined for compounds of formula (I), and X 0 is a halogen, preferably chlorine, bromine or iodine, with a compound of formula (VII) 5 is hydrogen or methyl, and R 7 , R 8 , R 9 , B 1 and B 2 can be prepared by reacting (as defined for compounds of formula (I)) with (as defined for compounds of formula (I)). This reaction is shown in Scheme 5. [ka] Scheme 5

[0207] The Suzuki-Miyaura cross-coupling reaction of a compound of formula (VIII) with a compound of formula (VII) is well known to those skilled in the art and is typically carried out in the presence of a palladium catalyst such as tetrakis(triphenylphosphine)-palladium(0) or [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride dichloromethane complex and a base such as sodium carbonate or potassium carbonate, in a solvent such as N,N-dimethylformamide, dioxane, or a dioxane-water mixture, at a temperature between room temperature and 160°C, optionally under microwave heating conditions, and preferably under an inert atmosphere. Such reactions are reviewed, for example, in J. Organomet. Chem. 1999, 576, 147-168. Those skilled in the art will appreciate that the reaction is reversible, i.e., the formation of a compound of formula (X) (wherein R 1 , R 2 and R 3 is as defined for compounds of formula (I)) and a compound of formula (IX) 5 is hydrogen or methyl, and R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), and X 0 is a halogen, preferably chlorine, bromine or iodine, to give a compound of formula (IVa), 4 and R 6 is hydrogen and R 5 is hydrogen or methyl, and R 1 , R 2 , R 3 , R 7 , R 8 , R 9 , B 1 and B 2 It will be appreciated that the reaction can also result in the reaction of the compound of formula (I) being as defined for the compound of formula (I). This reaction is shown in Scheme 6. [ka] Scheme 6

[0208] Further cross-coupling chemistry, i.e., C—H activation, can be used to prepare compounds of formula (IVa), where R 4 and R 6 is hydrogen and R 5 is hydrogen or methyl, and R 1 , R 2 , R 3 , R 7 , R 8 , R 9 , B 1 and B 2 may also be used for the preparation of compounds of formula (I) (Scheme 7). [ka] Scheme 7

[0209] As shown in Scheme 7, a compound of formula (IX) (wherein R 5 is hydrogen or methyl, and R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), and X 0 is a halogen, preferably chlorine, bromine or iodine, in the presence of a palladium catalyst, typically palladium acetate Pd(OAc)2, a suitable ligand, for example 1,10-phenanthroline, in the presence of a base such as cesium carbonate or potassium carbonate, in an inert solvent such as chlorobenzene, toluene or xylene, at a temperature between room temperature and 180°C, optionally under microwave heating conditions, preferably under an inert atmosphere, to give a compound of formula (XI) (wherein R 1 , R 2 and R 3 is as defined for compounds of formula (I)). Similar conditions are reported in the literature, for example in Chem. Sci. 2013, 4, 2374-2379.

[0210] Compounds of formula (III) can also be prepared from compounds of formula (XVI) (Scheme 8). [ka] Scheme 8

[0211] As shown in Scheme 8, a compound of formula (III) can be prepared by condensing a compound of formula (XVI), where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), and R 01 can be prepared by one skilled in the art by carbamate deprotection of a common carbamate protecting group substituent (which may be a component of a methyl, tert-butyl, allyl, 2,2,2-trichloroethyl, or benzyl group). 01 When is methyl, the product can be obtained by heating at room temperature to 200°C, preferably 20°C to the boiling point of the reaction mixture, using a suitable solvent such as dichloromethane and a suitable reagent such as iodotrimethylsilane, as described in, for example, J. Am. Chem. Soc. 1992, 114, 5959. The compound of formula (III) thus obtained is converted to a compound of formula (I) (Scheme 1).

[0212] A compound of formula (XVI) 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), and R 01 is as defined above) can be converted to an aldehyde of formula (XV) (including formaldehyde in its various forms) (wherein R 7is as defined for compounds of formula (I)) and a compound of formula (XIV) 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), and R 01 can be formed by the Pictet-Spengler reaction with (as described above) (Scheme 9). [ka] Scheme 9

[0213] A compound of formula (XIV) 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), and R 01 is as defined above) can be reacted with an amine of formula (XIII) (wherein R is as defined above), optionally in the presence of a base such as triethylamine or pyridine, in a suitable solvent such as dichloromethane, at a temperature between −20° C. and the boiling point of the mixture, as described, for example, in Org. Biomol. Chem. 2016 14, 6853. 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , B 1 and B 2 can be prepared by reaction of a compound of formula (I) (as defined above for compounds of formula (I)) with a suitable protecting reagent such as methyl chloroformate. This reaction is shown in Scheme 10. [ka] Scheme 10

[0214] A compound of formula (XIII) or a salt thereof (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), can be prepared by reacting a nitrile of formula (XII), where R 1 , R 2 , R 3 , R 4 , R 8 , R 9 , B 1 and B 2 can be prepared by one skilled in the art by reaction of a Grignard reagent R (which is as defined for compounds of formula (I)) with a suitable nucleophile such as (dimethylsulfide)dihydroboron (BMS). Alternatively, the Grignard reagent R 5 MgBr or R 6 MgBr (wherein, R 5 and R 6 (wherein X is as defined for compounds of formula (I)) may be added sequentially or simultaneously as a nucleophile to compounds of formula (XII) to allow the preparation of more highly substituted amines of formula (XIII). Such Grignard additions to nitriles can be carried out in inert solvents such as diethyl ether, tert-butyl methyl ether, and cyclopentyl methyl ether using Ti(O- i The reaction is carried out in the presence of a Lewis acid such as Pr) (see Synlett 2007, (4), 652-654). This reaction is shown in Scheme 11. [ka] Scheme 11

[0215] Alternatively, a compound of formula (XIII) 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), and R 5 and R 6 is hydrogen), i.e., the compound of formula (XIIIa) can be prepared by the addition of an unsaturated nitro compound of formula (XIIIb), 1 , R 2 , R 3 , R 4 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I)) and a compound of formula (VIII) 1 , R 2 , R 3 is as defined for compounds of formula (I), and X 0 is a halogen, preferably iodine), followed by reaction with a compound of formula (XIIIb), 1 , R 2 , R 3 , R 4 , R 8 , R 9 , B 1 and B 2 can be prepared by one skilled in the art by reacting a compound of formula (XIIIa) (which is defined as for compounds of formula (I)) to a compound of formula (XIIIa). Such a reaction is described in the preliminary section of Example P1, Step 8 (Appendix B - Steps A and B). This reaction is shown in Scheme 12. [ka] Scheme 12

[0216] A compound of formula (XII) 1 , R 2 , R 3 , R4 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I)) can be prepared by one skilled in the art according to known methods. More specifically, compounds of formula (XII) and intermediates thereto can be prepared from compounds of formula (XVII) as shown in Scheme 13. [ka] Scheme 13

[0217] For example, a compound of formula (XII) 1 , R 2 , R 3 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), and R 4 is different from hydrogen) can be prepared by the synthesis of compounds of formula (XIIa) (wherein R 1 , R 2 , R 3 , R 8 , R 9 , B 1 and B 2 is as defined for compounds of formula (I), followed by deprotonation of a suitable alkylating agent R, such as iodomethane 4 -X(where R 4 is a C1-C4 alkyl and X is a halogen).

[0218] A compound of formula (XIIa) 1 , R 2 , R 3 , R 8 , R 9 , B 1 and B 2(wherein X is as defined for compounds of formula (I)) can be prepared from alcohols of formula (XVII) by treatment with cyanotrimethylsilane (TMSCN) in the presence of a base such as lithium carbonate in a non-polar solvent such as dichloromethane at temperatures between 0° C. and the boiling point of the reaction mixture. Such transformations are well known in the literature under a variety of conditions, for example, as described in Org. Lett. 2008, 10, 4570 and references therein. This reaction is shown in Scheme 13.

[0219] A compound of formula (III) 1 is CR 10 and B 2 is CR 11 and R 1a is C1-C4 alkyl, and R 2a is hydrogen, halogen or C1-C4 alkyl, and R 3 is hydrogen and R 4a , R 5a , R 6a , R 7a is hydrogen or C1-C4 alkyl, and R 8 , R 9 , R 10 and R 11 is as defined for compounds of formula (I)), i.e. further synthesis of compounds of formula (IIIc) is described below. [ka]

[0220] The compound of formula (IIIc) can be prepared from a compound of formula (XVIII) [ka] (In the formula, R 1 is C1-C4 alkyl, and R 2 is hydrogen, halogen or C1-C4 alkyl, and R 3 is hydrogen and R 4 is hydrogen or C1-C4 alkyl, and R 5 , R 6 , R 7is hydrogen or C1-C4 alkyl, and R 8 , R 9 , R 10 and R 11 are as already defined) with a strong acid such as sulfuric acid, hydrochloric acid, hydrobromic acid, trifluoroacetic acid, triflic acid, or methanesulfonic acid, or a Lewis acid such as aluminum oxychloride or bismuth(III) triflate, in an inert solvent such as chlorobenzene or nitrobenzene, at a temperature between 0°C and 180°C, to give compounds of formula (IIIc). These are converted to compounds of formula (I) as described above. Those skilled in the art will appreciate that such cyclization can be carried out in the presence of a compound of formula (XIX) [ka] and (R 4 When is methyl, formula (XX) [ka] (wherein the substituent R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 and R 11 is as defined for compounds of formula (I) It will be appreciated that one may proceed through intermediates such as compounds of formula (IIIc). Depending on the reaction conditions, these intermediates may be isolated and / or further converted directly to compounds of formula (IIIc). Those skilled in the art will appreciate that R 7 It will also be appreciated that when is a C1-C4 alkyl, mixtures of diastereomeric racemates (syn-IIIc) and racemates (anti-IIIc) can be obtained in controllable ratios such that one isomer is formed preferentially over the other (Scheme 14). [ka] Scheme 14

[0221] Intermediates (XVIII), (XIX) and (XX) are novel and therefore form a further part of the present invention. Compounds (XVIII), (XIX) and (XX) can be prepared as shown in Scheme 15 below. [ka] Scheme 15

[0222] As shown in Scheme 15, a benzylamine of formula (XXI) is used to alkylate a compound of formula (XXII) in an inert solvent such as DMF in the presence of a base such as EtN. The compound (XXIII) thus obtained can be isolated or directly treated in situ with BOC-anhydride to give a compound of formula (XXIV). The compound of formula (XXIV) can be reduced with a hydride source (e.g., NaBH in MeOH / THF) to give the target molecule (XVIIIb), which can then be cyclized with, for example, camphorsulfonic acid in EtOAc to give a compound of formula (XIXb). Alternatively, the compound of formula (XXIV) can be reacted with a Grignard reagent R in an inert ether solvent (e.g., THF) to give the target molecule (XVIIIb). 4 MgBr to give a compound of formula (XVIIIa), which can be cyclized with camphorsulfonic acid, for example, in EtOAc, to give a compound of formula (XIXa). 1a is C1-C4 alkyl, and R 2a is hydrogen, halogen or C1-C4 alkyl, and R 4a is hydrogen or C1-C4 alkyl, and R 5a , R 6a and R 7a is hydrogen or C1-C4 alkyl, and R 8 , R 9 , R 10 and R 11 is as defined for formula (I).

[0223] Note also a further aspect of this Friedel-Crafts chemistry: when chemistry is carried out starting from chiral amines (XXIa), i.e., R 7 When R is C1-C4 alkyl, the stereochemistry is retained in the final compound of formula (I). 7 The case where is methyl is shown below in Scheme 16. [ka] Scheme 16

[0224] Compounds of formula (XVII) can be prepared by methods known to those skilled in the art. Compounds of formula (XXI) and (XXII) can be readily prepared or purchased by those skilled in the art.

[0225] A compound of formula II, 1 is N and A 2 is O and A 3 is CH and Z 1 is as defined for compounds of formula (I), i.e. compounds of formula (IIc), may be prepared as shown in Scheme 17. [ka] Scheme 17

[0226] As shown in Scheme 17, compounds of formula (IIc) (wherein Z1 is as defined for compounds of formula (I) and X 05 is C1-C4 alkyl) can be prepared by hydrolysis of a compound of formula (IIb), for example, by treatment with an alkaline earth metal hydroxide in water or a water-miscible organic solvent such as THF, methanol, ethanol, etc. Such ester hydrolysis is well known to those skilled in the art. Compounds of formula (IIb) can be prepared by hydrolysis of a compound of formula (XXVII), where Z 1 is as defined for compounds of formula (I), and X 05is a C1-C4 alkyl) with hydroxylamine hydrochloride in a polar solvent such as ethanol and optionally in the presence of, for example, triethylamine, K2CO3, or the like.

[0227] Compounds of formula (XXVII) can be prepared by reacting compounds of formula (XXV) (wherein Z 1 is as defined for compounds of formula (I), a compound of formula (XXVI) or a compound of formula (XXVIa) (wherein X 05 is C1-C4 alkyl). Similar reaction sequences to those described in Scheme 17 for preparing compounds of formula (IIb) and (IIc) are described, for example, in CN 111072582, WO 2019 / 195810 and WO 2018 / 019929. Further reaction conditions for preparing compounds of formula (XXVII) are described, for example, in Bioorg.Med.Chem.2016,109,350-359.

[0228] A compound of formula (II) 1 is O and A 2 and A 3 is N and Z 1 is as defined for compounds of formula (I), i.e. compounds of formula (IIe), can be prepared as shown in Scheme 18. [ka] Scheme 18

[0229] As shown in Scheme 18, compounds of formula (IIe) are obtained by ester hydrolysis of compounds of formula (IId) previously described in Scheme 17. Compounds of formula (IId) (wherein Z 1 is as defined for compounds of formula (I), and X 05is C1-C4 alkyl) can be prepared by reacting a compound of formula (XXVIa) with a compound of formula (XXVIII), optionally in the presence of a base such as pyridine or triethylamine, in a solvent such as acetonitrile, chloroform or tetrahydrofuran. Similar reactions have been reported, for example, in Bioorg.Med.Chem.2016,24(22),5693-5701 and Chinese Patent No. 114933573. Compounds of formula (XXVIII) (wherein Z 1 (wherein R is as defined for compounds of formula (I)) can be obtained by treating compounds of formula (XXIX) with hydroxylamine hydrochloride in the presence of a base such as KCO or NaCO in a polar solvent, such as ethanol. The reaction can also be carried out without a base using a hydroxylamine solution. Such reactions are described, for example, in Med. Chem. Lett. 2020, 30(21), 127508 and Bioorg. Med. Chem. Lett. 2016, 26(23), 5679-5684.

[0230] A compound of formula (XXVIII) 1 is as defined for compounds of formula (I), can be prepared by Pd-catalyzed reaction of compounds of formula (XXX), where Z is as defined for compounds of formula (I), using potassium ferricyanide trihydrate and hydroxylamine hydrochloride, as described, for example, in Org. Biomol. Chem. 2015, 13(9), 2541-2545. 1 may also be prepared by a "one-spot" synthesis by cyanation and amidoximation of (as defined for compounds of formula (I)).

[0231] A compound of formula (II) 1 and A 2 is N and A 3 is O and Z 1 is as described above (i.e., a compound of formula (IIg)), and A 1 and A 2 is N and A 3is S and Z1 is as defined for compounds of formula (I) (i.e. compounds of formula (IIi)) may be prepared as shown in Scheme 19. [ka] Scheme 19

[0232] As shown in Scheme 19, compounds of formula (IIg) and (IIi) are accessible by ester hydrolysis of (IIf) and (IIg), respectively. In the latter compounds, X 05 and Z 1 is as described above. Compounds of formula (IIf) can be obtained from compounds of formula (IIf) and by dehydration of compounds of formula (XXXI). Compounds of formula (XXXI) can be obtained by acylation with hydrazides of formula (XXXII) and compounds of formula (XXVIa). Such reaction sequences for producing oxadiazoles are well known to those skilled in the art. Similar reactions are described in Bioorg. Med. Chem. Lett. 2005, 15, 1423-1428 and WO 2006 / 044617. Compounds of formula (XXXI) can be obtained by acylation of activated carboxylic acids of formula (XXXIIIa) (wherein Z 1 is as defined for compounds of formula (I), and X 0 can also be prepared by reaction of a compound of formula (XXXIV) with a compound of formula (XXXIIIa) as described in Scheme 1 / Scheme 1a, respectively. Compounds of formula (XXXIIIa) can be prepared from the corresponding acid of formula (XXXIII), as described in Scheme 1. Such reactions are described, for example, in J. Prakt. Chem. 1985, 327, 109-116. Compounds of formula (IIh) can be prepared by reaction of a general intermediate of formula (XXXI) (wherein Z 1 is as defined for compounds of formula (I), and X 05(as previously described) can also be prepared by treatment with Lawesson's reagent or neat phosphoric acid pentasulfide or in an inert solvent such as toluene or xylene. Similar reactions are known in the literature (see, for example, WO 2010 / 006713, WO 2009 / 149858 and J. Org Chem. 1961, 26, 4410-12).

[0233] A compound of formula (II) 1 is O and A 2 is N and A 3 is a methine, and Z 1 is as defined for compounds of formula (I), i.e. compounds of formula (IIk), can be prepared as shown in Scheme 20. [ka] Scheme 20

[0234] As shown in Scheme 20, compounds of formula (IIk) are readily available by hydrolysis of esters of formula (IIj) by methods well known to those skilled in the art and described above. Compounds of formula (IIj) can be obtained by reaction of compounds of formula (XXXV) with compounds of formula (XXXVI) in the presence of an oxidizing agent, such as (diacetoxyiodo)benzene or N-chlorosuccinimide, in an inert solvent such as methanol or DMF, respectively. Such reaction sequences are described, for example, in J. Het. Chem. 2013, 50(4), 774-780 and J. Chin. Chem. Soc. 2007, 54(3), 643-652. Compounds of formula (XXXV) can be converted to compounds of formula (XXXVII) (wherein Z is a hydroxylamine-containing amine) by treatment with hydroxylamine under conditions well known to those skilled in the art. 1 is readily prepared from (as defined for compounds of formula (I)).

[0235] Salts of compounds of formula (I) can be prepared in a manner known per se: thus, for example, acid addition salts of compounds of formula (I) can be obtained by treatment with a suitable acid or with a suitable ion exchange reagent, and salts with bases can be obtained by treatment with a suitable base or with a suitable ion exchange reagent.

[0236] Salts of compounds of formula (I) may be converted in customary manner, for example into the free compounds I (acid addition salts) by treatment with a suitable basic compound or a suitable ion exchange reagent, or into salts with a base, for example by treatment with a suitable acid or a suitable ion exchange reagent.

[0237] Salts of compounds of formula (I) may be converted into other salts (acid addition salts, e.g. other acid addition salts) of compounds of formula (I) in a manner known per se, for example by treating the salt of an inorganic acid, such as hydrochloric acid, with a suitable metal salt of the acid, such as sodium, barium or silver salt (e.g. silver acetate), in a suitable solvent (in which inorganic salts that form, for example, silver chloride, are insoluble and therefore precipitate from the reaction mixture).

[0238] Depending on the procedure or reaction conditions, compounds of formula (I) that have salt-forming properties may be obtained in the free form or in salt form.

[0239] The compounds of formula (I) and, where appropriate, their tautomers, in each free or salt form, may exist in the form of pure isomers, such as enantiomers and / or diastereomers, or as isomeric mixtures, such as enantiomeric mixtures, e.g. racemates, diastereomeric mixtures, depending on the number, absolute and relative configuration of asymmetric carbon atoms occurring in the molecule and / or depending on the configuration of non-aromatic double bonds occurring in the molecule, in one of the possible isomers or as mixtures thereof; the invention relates to the pure isomers and also to all possible isomeric mixtures, and is to be understood in this sense above and below, respectively, even if details of the stereochemistry are not specifically stated in each case.

[0240] Diastereomeric or racemic mixtures of compounds of formula (I), in free or salt form, obtained depending on which starting materials and procedures are selected, can be separated in known manner on the basis of the physical chemical differences of the components into pure diastereomers or racemates, for example by fractional crystallization, distillation and / or chromatography.

[0241] Enantiomeric mixtures, such as racemates, obtainable in a similar manner can be resolved into their optical antipodes by known methods, such as, for example, recrystallization from optically active solvents, chromatography on chiral adsorbents, e.g., high-performance liquid chromatography (HPLC) on acetylcellulose using suitable microorganisms, cleavage by specific immobilized enzymes, in which only one enantiomer is complexed, e.g., via the formation of inclusion compounds with chiral crown ethers, or by conversion into diastereomeric salts, for example, by reacting the basic end-product racemate with an optically active acid, such as a carboxylic acid, e.g., camphoric acid, tartaric acid, or malic acid, or a sulfonic acid, e.g., camphorsulfonic acid, and separating the diastereomeric mixtures thereby obtainable, e.g., by fractional crystallization according to their different solubilities, to give diastereomers from which the desired enantiomer can be liberated by the action of a suitable agent, e.g., a basic agent.

[0242] Pure diastereomers or enantiomers can be obtained according to the invention not only by separating the appropriate isomeric mixture, but also by diastereoselective or enantioselective synthesis, which is a method known in the art, e.g., by carrying out the process according to the invention using starting materials with the appropriate stereochemistry.

[0243] When the individual components have different biological activities, it may be advantageous to isolate or synthesize the respective more biologically active isomer, e.g., enantiomer or diastereomer, or mixture of isomers, e.g., mixture of enantiomers or diastereomers.

[0244] As an example, compounds with two or more asymmetric carbon atoms may exist in diastereoisomeric forms which can optionally be separated using, for example, supercritical fluid chromatography (SFC) chromatography with a chiral column. Although such diastereomers may exhibit different fungicidal activity profiles, all isomers and diastereomers form part of the present invention.

[0245] The compounds of formula (I) have three chiral carbon atoms (three stereocenters, star-shaped ( * ) indicates a chiral carbon atom, and therefore eight stereoisomers are available. These eight stereoisomers consist of four sets of enantiomers. [ka]

[0246] A compound of formula I, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , B 1 , B 2 , A(A 1 , A 2 , A 3 ) and Z 1 is as defined for compounds of formula (I), and R 7 The relationship between enantiomers and diastereomers for the 2-amino group (where 2 is not hydrogen) is shown in Scheme 21. [ka] [ka] Scheme 21

[0247] Those skilled in the art will recognize that compounds of formula (I) (as shown in Scheme 21) 1 , R 2 , R 3 , R 4 , R5 , R 6 , R 7 , R 8 , R 9 , B 1 , B 2 , A(A 1 , A 2 , A 3 ) and Z 1 is as defined for formula (I), and R 7 is not hydrogen) are well understood to be within the scope of the present invention.

[0248] A compound of formula I, wherein R 1 is methyl and R 3 , R 4 , R 5 , R 6 is hydrogen and R 2 , R 7 , R 8 , R 9 , B 1 , B 2 and Z 1 is as defined for compounds of formula (I), A is as defined for compounds of formula (IA), and R 7 is not hydrogen), the relationship between enantiomers and diastereomers is shown in Scheme 22. [ka] Scheme 22

[0249] In one embodiment, a compound of formula (I), wherein R 1 is methyl and R 3 , R 4 , R 5 , R 6 is hydrogen and R 2 , R 7 , R 8 , R 9 , B 1 , B 2 and Z 1 is as defined for compounds of formula (I), A is as defined for compounds of formula (IA), and R 7is not hydrogen), the pyrazole moiety and R 7 The moieties have a syn relationship to each other.

[0250] The syn isomer of the compound of formula (I) (wherein R 1 is methyl and R 3 , R 4 , R 5 , R 6 is hydrogen and R 2 , R 7 , R 8 , R 9 , B 1 , B 2 and Z 1 is as defined for compounds of formula (I), A is as defined for compounds of formula (IA), and R 7 is not hydrogen) is shown in Scheme 23. [ka] Scheme 23

[0251] Preferably, the compound of formula (I) 1 is methyl and R 3 , R 4 , R 5 , R 6 is hydrogen and R 2 , R 7 , R 8 , R 9 , B 1 , B 2 and Z 1 is as defined for compounds of formula (I), A is as defined for compounds of formula (IA), and R 7 is not hydrogen), the pyrazole moiety and R 7 The moieties have a syn relationship to each other.

[0252] The term "compound of formula (I)" refers to component A.

[0253] As used herein, the term "fungicide" means a compound that controls, modifies, or prevents the growth of fungi.

[0254] The term "fungicidally effective amount" means an amount of such a compound or combination of such compounds that is capable of producing an effect on fungal growth. A controlling or modifying effect includes any deviation from natural occurrence, such as killing, retarding, etc., and prevention includes the formation of a barrier or other defense in the plant to prevent fungal infection.

[0255] The term "plant" refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, leaves and fruits.

[0256] The term "plant propagation material" refers to all reproductive parts of a plant, such as seeds or cuttings and vegetative parts of a plant, such as tubers. It includes seeds in the strict sense as well as roots, fruits, tubers, bulbs, rhizomes and plant parts.

[0257] The term "habitat" as used herein means the field in or on which plants are growing, or the field in which seeds of cultivated plants are sown, or the field in whose soil seeds will be sown. It includes the soil, seeds and seedlings, and established vegetation.

[0258] As used herein, the term "g ai / ha" refers to an application rate expressed in grams [g] of active ingredient [ai] per unit surface [ha]. The unit hectare (symbol ha) is the area of ​​100 m side (1 hm 2 ) square or 10,000 square meters. The hectare is a commonly used unit of area in the metric system.

[0259] As used herein, the term "controlling" refers to reducing the number of pests, eliminating pests, and / or preventing further pest damage so that damage to plants or plant-derived products is reduced.

[0260] As used herein, the term "pest" refers to insects and mollusks found in agriculture, horticulture, forestry, storing plant-derived products (such as fruit, grain, and timber), and pests associated with damaging man-made structures. The term pest includes all stages of the pest life cycle.

[0261] As used herein, the term "effective amount" refers to an amount of a compound or a salt thereof that produces a desired effect upon single or multiple applications.

[0262] Effective amounts are readily determined by those skilled in the art by the use of known techniques and by observing results obtained under analogous circumstances. Determining an effective amount takes into account several factors, including, but not limited to, the type of plant or derived product applied, the pest being controlled and its life cycle, the particular compound applied, the type of application, and other relevant circumstances.

[0263] As used herein, the terms "room temperature" or "RT" or "rt" refer to a temperature of about 15°C to about 35°C. For example, rt can refer to a temperature of about 20°C to about 30°C.

[0264] Throughout this specification, the expression "composition" refers to various mixtures or combinations of components (A) and (B) (including the embodiments defined above), such as single "ready-mixed" forms, multiple spray mixtures such as "tank mixes" composed of individual combinations of single active ingredient components, and combinations of single active ingredients when applied sequentially (i.e., one after the other within a reasonably short time, such as hours or days). The order in which components (A) and (B) are applied is not critical to the practice of this invention.

[0265] The compositions of the present invention are effective against harmful microorganisms, such as those that cause plant pathogenic diseases, particularly plant pathogenic fungi and bacteria.

[0266] The compositions of the present invention can be used to control plant diseases caused by a wide range of fungal plant pathogens in the classes Basidiomycete, Ascomycete, Oomycete and / or Deuteromycete, Blastocladiomycete, Chrytidiomycete, Glomeromycete and / or Mucoromycete.

[0267] The compositions are effective in controlling a broad range of plant diseases, including foliar pathogens of ornamental crops, turf, vegetables, field crops, cereals and fruit crops.

[0268] These pathogens may include: Oomycete, including: Phytophthora diseases such as those caused by Phytophthora capsici, Phytophthora infestans, Phytophthora sojae, Phytophthora fragariae, Phytophthora nicotianae, Phytophthora cinnamomi, Phytophthora citricola, Phytophthora citrophthora, and Phytophthora erythroseptica; Pythium aphanidermatum Pythium diseases such as those caused by Pythium aphanidermatum, Pythium arrhenomanes, Pythium graminicola, Pythium irregulare, and Pythium ultimum;Diseases caused by Peronosporales, such as Peronospora destructor, Peronospora parasitica, Plasmopara viticola, Plasmopara halstedii, Pseudoperonospora cubensis, Albugo candida, Sclerophthora macrospora, and Bremia lactucae, as well as diseases caused by Aphanomyces cochlioides, Labyrinthula zosterae, Peronosclerospora sorgi, and Peronosclerospora others, such as Sclerospora sorghi and Sclerospora graminicola; Ascomycetes, including, for example, Stemphylium solani, Stagonospora tainanensis, Spirocaea oleaginea, Setosphaeria turcica, Pyrenochaeta lycoperisici, Pleospora herbarum, Phoma destructiva, Phaeosphaeria herpotrichoides, Phaeocryptocus gaeumannii, Ophiosphaerella graminicola, Ophiobolus graminis graminis, Leptosphaeria maculans, Hendersonia creberrima, Helminthosporium triticirepentis, Setosphaeria turcica, Drechslera glycines, Didymella bryoniae, Cycloconium oleagineum, Corynespora cassiicola, Cochliobolus sativus, Bipolaris cactivora, Venturia inaequalis, Pyrenophora teres), wheat yellow spot fungus (Pyrenophora tritici-repentis), Alternaria alternata, Alternaria brassicicolathe Pleosporales, such as Alternaria brassicicola, Alternaria solani, and Alternaria tomatophila; Septoria tritici, Septoria nodorum, Septoria glycines, Cercospora arachidicola, Cercospora sojina, Cercospora zeae-maydis, Cercosporella capsellae, and Cercosporella herpotrichoides, Cladosporium carpophilum, Cladosporium efsum, and the like; effusum, Passalora fulva, Cladosporium oxysporum, Dothistroma septosporum, Isariopsis clavispora, Mycosphaerella fijiensis, Mycosphaerella graminicola, Mycovellosiella koepkeii, Phaeoisariopsis bataticola, Pseudocercospora vitis, Pseudocercosporella herpotrichoides, Ramularia beticola, Ramularia collo-cygni, and other Capnodiales; Gaeumannomyces graminisMagnaporthales such as Magnaporthe grisea, Pyricularia oryzae, Anisogramma anomala, Apiognomonia errabunda, Cytospora platani, Diaporthe phaseolorum, Discula destructiva, Gnomonia fructicola, Greeneria uvicola, Melanconium juglandinum, Phomopsis viticola, Sirococcus clavigignenti-Juglandacearum, and others. Diaporthales such as C. clavigignenti-juglandacearum, Tubakia dryina, Dicarpella spp., Valsa ceratosperma, as well as Actinothyrium graminis, Ascochyta pisi, Aspergillus flavus, Aspergillus fumigatus, Aspergillus nidulans, Asperisporium caricae, Blumeriella jaapii, Candida spp., and Capnodium ramosum. ramosum, Cephaloascus spp., Cephalosporium gramineum, Ceratocystis paradoxa, Chaetomiumspp., Hymenoscyphus pseudoalbidus, Coccidioides spp., Cylindrosporium padi, Diplocarpon malae, Drepanopeziza campestris, Elsinoe ampelina, Epicoccum nigrum, Epidermophyton spp., Eutypa lata, Geotrichum candidum, Gibellina cerealis, Gloeocercospora sorghini Others such as Gloeodes pomigena, Gloeosporium perennans, Gloeotinia temulenta, Griphospaeria corticola, Kabatiella lini, Leptographium microsporum, Leptosphaerulinia crassiasca, Lophodermium seditiosum, Marssonina graminicola, Microdochium nivale, Monilinia fructicola, Monographella arvensis albescens, Monosporascus cannonballus, Naemacyclus spp., Ophiostomanovo-ulmi, Paracoccidioides brasiliensisbrasiliensis, Penicillium expansum, Pestalotia rhododendri, Petriellidium spp., Pezicula spp., Phialophora gregata, Phyllachora pomigena, Phymatotrichum omnivora, Physalospora abdita, Plectosporium tabacinum, Polyscytalum pustulans, Pseudopeziza medica ginseng medicaginis, Pyrenopeziza brassicae, Ramulispora sorghi, Rhabdocline pseudotsugae, Rhynchosporium secalis, Sacrocladium oryzae, Scedosporium spp., Schizothyrium pomi, Sclerotinia sclerotiorum, Sclerotinia minor, Sclerotium spp., Typhula ishikariensis, Seimatosporium mariae, Lepteutypa cupressi, Septocyta ruborum, Sphaceloma perseae, Sporonema phacidioides, Stigmina palmivora, Tapesia yardensisyallundae, Taphrina bullata, Thielviopsis basicola, Trichoseptoria fructigena, Zygophiala jamaicensis, and other diseases such as spot blotch and spot spot, Rice blast or blight and / or rot diseases; for example Blumeria graminis, Erysiphe polygoni, Uncinula necator, Sphaerotheca fuligena, apple powdery mildew (Podosphaera leucotricha), Podospaera macularis, Golovinomyces cichoracearum, Leveillula taurica, Microsphaera diffusa, Oidiopsis gossypii, Phyllactinia guttata and Oidium arachidis Powdery mildew diseases, such as those caused by Erysiphales, such as Dothiorella aromatica, Diplodia seriata, Guignardia bidwellii, Botrytis cinerea, Botryotinia allii, Botryotinia fabae, Fusicoccum amygdali, Lasiodiplodia theobromae, Macrophoma theicola, Macrophomina phaseolina, Phyllosticta curbitacearum, fungi, such as those caused by Botryosphaeriales such as Botryosphaeriaceae (Bombyx mori) and Botryosphaeriaceae (Bombyx mori);Anthracnose, such as those caused by Glommerelales species such as Colletotrichum gloeosporioides, Colletotrichum lagenarium, Colletotrichum gossypii, Glomerella cingulata and Colletotrichum graminicola, as well as species such as Acremonium strictum, Claviceps purpurea, Fusarium culmorum, Fusarium graminearum, Fusarium virguliforme, Fusarium oxysporum, oxysporum, Fusarium subglutinans, Fusarium oxysporum f.sp. cubense, Gerlachia nivale, Gibberella fujikuroi, Gibberella zeae, Gliocladium spp., Myrothecium verrucaria, Nectria ramulariae, Trichoderma viride, Trichothecium roseum and Verticillium theobromae Wilt or blight, such as those caused by Hypocreales such as Hypocreales theobromae; Basidiomycete, including: smut fungi such as those caused by the Ustilaginales, e.g., Ustilaginoidea virens, Ustilago nuda, Ustilago tritici, Ustilago zeae; e.g., Cerotelium fici, Chrysomyxa arctostaphyli, Coleosporium ipomoeae, Hemileia vastatrix, Puccinia arachidis, Puccinia cacabata, Puccinia graminis; graminis, Puccinia recondita, Puccinia sorghi, Puccinia hordei, Puccinia striiformis f.sp. Hordei, Puccinia striiformis f.sp. sekarisRust fungi such as those caused by the Uredinales, such as Cronartium ribicola, Gymnosporangium juniperi-virginianae, Melampsora medusae, Phakopsora pachyrhizi, Phragmidium mucronatum, Physopella ampelosidis, Tranzschelia discolor and Uromyces viciae-fabae, and Cryptococcus spp. spp.), Exobasidium vexans, Marasmiellus inoderma, Mycena spp., Sphacelotheca reiliana, Typhula ishikariensis, Urocystis agropyri, Itersonilia perplexans, Corticium invisum, Laetisaria fuciformis, Waitea circinata, Rhizoctonia solani, Thanetephorus cucurmeris, Entyloma Other decays and diseases such as those caused by Bacillus dahliae, Entylomella microspora, Neovossia moliniae and Tilletia caries. Blastocladiomycetes, such as Physoderma maydis, Mucoromycetes such as Choanephora cucurbitarum; Mucor spp.; Rhizopus arrhizus; and Diseases caused by other species and genera related to those listed above.

[0269] In addition to its fungicidal activity, the composition may also have activity against bacteria such as Erwinia amylovora, Erwinia caratovora, Xanthomonas campestris, Pseudomonas syringae, Streptomyces scabies and other related species, as well as certain protozoa.

[0270] The compositions according to the invention are particularly effective against plant pathogenic fungi belonging to the following classes: Ascomycete (e.g., Venturia, Podosphaera, Erysiphe, Monilinia, Mycosphaerella, Uncinula); Basidiomycete (e.g., Hemileia, Rhizoctonia, Phakopsora, Puccinia, Ustilago, Tilletia); Fungi imperfecti (e.g., Fungi spp ... imperfecti (also known as Deuteromycetes; e.g., Botrytis, Helminthosporium, Rhynchosporium, Fusarium, Septoria, Cercospora, Alternaria, Pyricularia, and Pseudocercosporella); Oomycetes (e.g., Phytophthora, Peronospora, Pseudoperonospora, Albugo, Bremia, Pythium, Pseudosclerospora, Plasmopara).

[0271] Useful plant crops in which the compositions according to the invention can be used include berry plants such as blackberries, blueberries, cranberries, raspberries and strawberries; cereals such as barley, corn (maize), millet, oats, rice, rye, sorghum, triticale and wheat; fiber plants such as cotton, flax, hemp, jute and sisal; field crops such as sugar and fodder beet, coffee, hops, mustard, rapeseed (canola), poppy, sugarcane, sunflower, tea and tobacco; fruit trees such as apple, apricot, avocado, banana, cherry, citrus, nectarine, peach, pear and plum; grasses such as bermudagrass, bluegrass, bentgrass, centipedegrass, fescue, ryegrass, St. Augustine grass and zoysiagrass; nuts such as almonds, cashews, groundnuts, hazelnuts, peanuts, pecans, pistachios and walnuts; palms such as oil palm; ornamental plants such as flowers, shrubs and trees; other trees such as cocoa, coconut, olives and rubber; vegetables such as asparagus, eggplant, broccoli, cabbage, carrots, cucumber, garlic, lettuce, marrow, melon, okra, onion, pepper, potato, pumpkin, rhubarb, spinach and tomato, and perennial and annual crops such as grapes.

[0272] Crops should be understood to be those that occur naturally, are obtained by traditional breeding methods, or are obtained by genetic engineering, and include crops that have so-called output traits (e.g., improved storage stability, high nutritional value, and improved flavor).

[0273] Crops should also be understood to include crops that have been made resistant to herbicides such as bromoxynil or herbicide classes such as ALS-, EPSPS-, GS-, HPPD-, and PPO-inhibitors. An example of a crop that has been made resistant to imidazolinones, such as imazamox, by conventional breeding methods is Clearfield® summer canola. Examples of crops that have been made resistant to herbicides by genetic engineering methods include, for example, glyphosate- and glufosinate-resistant corn varieties commercially available under the trade names RoundupReady®, Herculex I®, and LibertyLink®.

[0274] It should be understood that crop plants may also be naturally or resistant to harmful insects. This includes plants that have been transformed, for example, using recombinant DNA technology, to be able to synthesize one or more selectively acting toxins, such as those known from toxin-producing bacteria. Examples of toxins that can be expressed include delta-endotoxins, vegetative insecticidal proteins (Vips), insecticidal proteins of nematode-symbiotic bacteria, and toxins produced by scorpions, spiders, wasps, and fungi.

[0275] An example of a crop engineered to express a Bacillus thuringiensis toxin is Bt corn KnockOut® (Syngenta Seeds). An example of a crop containing two or more genes encoding insecticide resistance and thus expressing two or more toxins is VipCot® (Syngenta Seeds). Crops or their seed material can also be resistant to multiple pests (so-called overlapping transgenic events when achieved by genetic modification). For example, a plant can have the ability to express an insecticidal protein and simultaneously be herbicide-resistant, such as Herculex I® (Dow AgroSciences, Pioneer Hi-Bred International).

[0276] The term "useful plants" should also be understood to include useful plants which have been transformed using recombinant DNA techniques so as to be able to synthesize one or more selectively acting toxins, such as those known from toxin-producing bacteria, in particular those of the genus Bacillus.

[0277] Examples of such plants include YieldGard® (corn varieties expressing CryIA(b) toxin); YieldGard Rootworm® (corn varieties expressing CryIIIB(b1) toxin); YieldGard Plus® (corn varieties expressing CryIA(b) and CryIIIB(b1) toxins); Starlink® (corn varieties expressing Cry9(c) toxin); Herculex I® (corn varieties expressing CryIF(a2) toxin and phosphinothricin N-acetyltransferase (PAT), an enzyme that confers resistance to glufosinate ammonium herbicides); NuCOTN 33B® (cotton varieties expressing CryIA(c) toxin); Bollgard I® (cotton varieties expressing CryIA(c) toxin); Bollgard II® (a cotton variety expressing CryIA(c) and CryIIA(b) toxins); VIPCOT® (a cotton variety expressing VIP toxin); NewLeaf® (a potato variety expressing CryIIIA toxin); NatureGard® Agrisure® GT Advantage (GA21 glyphosate tolerance trait), Agrisure® CB Advantage (Bt11 corn borer (CB) resistance trait), Agrisure® RW (a corn rootworm resistance trait), and Protecta®.

[0278] The term "crop plant" should also be understood to include crop plants that have been transformed using recombinant DNA techniques to be able to synthesize one or more selectively acting toxins, such as those known from toxin-producing bacteria, particularly those belonging to the genus Bacillus.

[0279] Toxins that can be expressed by transgenic plants include, for example, insecticidal proteins from Bacillus cereus or Bacillus popilliae, or insecticidal proteins from Bacillus thuringiensis, such as δ-endotoxins, e.g., Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1, or Cry9C, or vegetative insecticidal proteins (Vip), e.g., Vip1, Vip2, Vip3, or Vip3A, or insecticidal proteins from Photorhabdus luminescens, Xenorhabdus nematophilus, e.g., Photorhabdus spp. or Xenorhabdus insecticidal proteins of nematode-symbiotic bacteria such as nematode toxins; toxins produced by animals such as scorpion toxins, spider toxins, wasp toxins and other insect-specific neurotoxins; toxins produced by fungi such as Streptomycete toxins, plant lectins such as pea lectin, barley lectin or snowdrop lectin; agglutinins; proteinase inhibitors such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin and papain inhibitors; ricin, Ribosome-inactivating proteins (RIPs) such as maize RIP, abrin, rufin, saporin or bryodin; steroid metabolic enzymes such as 3-hydroxysteroid oxidase, ecdysteroid-UDP-glycosyl-transferase, cholesterol oxidase, ecdysone inhibitors, HMG-COA-reductase, ion channel blockers such as sodium or calcium blockers, juvenile hormone esterase, diuretic hormone receptor, stilbene synthase, bibenzyl synthase, chitinase and glucanase.

[0280] In the context of the present invention, delta-endotoxins such as Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1, or Cry9C, or trophic insecticidal proteins (Vips) such as Vip1, Vip2, Vip3, or Vip3A, are also understood to be, in particular, hybrid toxins, truncated toxins, and modified toxins. Hybrid toxins are produced recombinantly by combining different domains of these proteins (see, for example, WO 02 / 15701). Truncated toxins are known, for example, as truncated Cry1Ab. Modified toxins have one or more amino acids substituted in a naturally occurring toxin. In such amino acid substitutions, a non-naturally occurring protease recognition sequence is preferably inserted into the toxin, for example, in the case of Cry3A055, a cathepsin-G recognition sequence is inserted into the Cry3A toxin (see WO 03 / 018810).

[0281] Examples of such toxins or transformed plants capable of synthesizing such toxins are disclosed, for example, in EP 0 374 753, WO 93 / 07278, WO 95 / 34656, EP 0 427 529, EP 451 878 and WO 03 / 052073.

[0282] The process for preparing such transgenic plants is generally known to those skilled in the art and is described, for example, in the publications mentioned above. CryI-type deoxyribonucleic acids and their preparation are known, for example, from WO 95 / 34656, EP 0 367 474, EP 0 401 979 and WO 90 / 13651.

[0283] The toxins contained in the transgenic plants confer resistance to harmful insects on the plants, which can be from any of the insect taxa, particularly those commonly found in beetles (Coleoptera), two-winged insects (Diptera), and butterflies (Lepidoptera).

[0284] Transgenic plants containing one or more genes encoding insecticide resistance and expressing one or more toxins are known, and some are commercially available. Examples of such plants include YieldGard® (a corn variety expressing the Cry1Ab toxin); YieldGard Rootworm® (a corn variety expressing the Cry3Bb1 toxin); YieldGard Plus® (a corn variety expressing the Cry1Ab and Cry3Bb1 toxins); Starlink® (a corn variety expressing the Cry9C toxin); Herculex I® (a corn variety expressing the Cry1Fa2 toxin and the enzyme phosphinothricin N-acetyltransferase (PAT) for tolerance to the herbicide glufosinate ammonium); NuCOTN 33B® (a cotton variety expressing the Cry1Ac toxin); Bollgard I® (a cotton variety expressing the Cry1Ac toxin); Bollgard II® (a cotton variety expressing Cry1Ac and Cry2Ab toxins); VipCot® (a cotton variety expressing Vip3A and Cry1Ab toxins); NewLeaf® (a potato variety expressing Cry3A toxin); NatureGard®, Agrisure® GT Advantage (GA21 glyphosate tolerance trait), Agrisure® CB Advantage (Bt11 corn borer (CB) trait), and Protecta®.

[0285] Further examples of such genetically modified crops include: 1. Bt11 maize, registration number C / FR / 96 / 05 / 10, manufactured by Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France. Genetically engineered maize (Zea mays) resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) through transgenic expression of a truncated Cry1Ab toxin. Bt11 maize also has tolerance to the herbicide glufosinate ammonium through transgenic expression of the PAT enzyme.

[0286] 2. Bt176 maize, registration number C / FR / 96 / 05 / 10, manufactured by Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France. This genetically engineered maize (Zea mays) is resistant to attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) through transgenic expression of the Cry1Ab toxin. Bt176 maize also has resistance to the herbicide glufosinate ammonium through transgenic expression of the PAT enzyme.

[0287] 3. MIR604 corn, registration number C / FR / 96 / 05 / 10, manufactured by Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France. This corn is resistant to insects through transgenic expression of a modified Cry3A toxin. The toxin is Cry3A055, modified by the insertion of a cathepsin-G-protease recognition sequence. The preparation of such transgenic corn plants is described in WO 03 / 018810.

[0288] 4. MON 863 Maize from Monsanto Europe SA270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C / DE / 02 / 9. MON863 expresses the Cry3Bb1 toxin and confers resistance to certain Coleoptera insects.

[0289] 5. IPC 531 Cotton from Monsanto Europe SA270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C / ES / 96 / 02.

[0290] 6. 1507 corn, registration number C / NL / 00 / 10, manufactured by Pioneer Overseas Corporation, Avenue Tedesco, 7 B-1160 Brussels, Belgium. Genetically modified corn for expression of the protein Cry1F to achieve resistance to certain lepidopteran insects and the protein PAT to achieve tolerance to the herbicide glufosinate ammonium.

[0291] 7. NK603 x MON810 corn, registration number C / GB / 02 / M3 / 03, manufactured by Monsanto Europe SA270-272 Avenue de Tervuren, B-1150 Brussels, Belgium. This conventionally bred hybrid corn variety was obtained by crossing the genetically modified varieties NK603 and MON 810. NK603 x MON810 corn transgenicly expresses the CP4 EPSPS protein from Agrobacterium sp. strain CP4, which confers resistance to the herbicide Roundup® (containing glyphosate), and also transgenicly expresses the Cry1Ab toxin from Bacillus thuringiensis subsp. kurstaki, which confers resistance to certain Lepidoptera, including the European corn borer.

[0292] Additionally, Absidia corymbifera, Alternaria spp., Aphanomyces spp., Ascochyta spp., Aspergillus spp. including A. flavus, A. fumigatus, A. nidulans, A. niger, A. terrus, Aureobasidium spp. including A. pullulans, Blastomyces dermatitidis, Blumeria graminis, Bremia lactucae, lactucae, Botryosphaeria spp. including B. dothidea, B. obtusa, Botrytis spp. including B. cinerea, Candida spp. including C. albicans, C. glabrata, C. krusei, C. lusitaniae, C. parapsilosis, C. tropicalis, Cephaloascus fragrans, Ceratocystis spp., Cercospora spp. including C. arachidicola, Cercosporidium personatum, Cladosporium spp., Claviceps purpurea, Coccidioides immitis, Cochliobolus spp., Colletotrichum spp. including C. musae.), Cryptococcus neoformans, Diaporthe spp., Didymella spp., Drechslera spp., Elsinoe spp., Epidermophyton spp., Erwinia amylovora, Erysiphe spp. including E. cichoracearum, Eutypa Fusarium spp., including F. lata, F. culmorum, F. graminearum, F. langsethiae, F. moniliforme, F. oxysporum, F. proliferatum, F. subglutinans, and F. solani, Gaeumannomyces graminis, Gibberella fujikuroi, Gloeodes pomigena, Gloeosporium musarum, and Glomerella cinquefolia. cingulate, Guignardia bidwellii, Gymnosporangium juniperi-virginianae, Helminthosporium spp., Hemileia spp., Histoplasma spp. including H. capsulatum.), Laetisaria fuciformis, Leptographium lindbergi, Leveillula taurica, Lophodermium seditiosum, Microdochium nivale, Microsporum spp., Monilinia spp., Mucor spp., M. graminicola, Mycosphaerella spp. including M. pomi, Oncobasidium theobromaeon, Ophiostoma piceae, Paracoccidioides spp., Penicillium spp. including P. digitatum, P. italicum, Petriellidium spp., Peronosclerospora spp. including P. maydis, P. philippinensis and P. sorghi, Peronosclerospora spp., Phaeosphaeria nodorum, Phakopsora pachyrhizi, Phellinus ignialus igniarus, Phialophora spp., Phoma spp., Phomopsis viticola, Phytophthora spp. including P. infestans, Plasmopara spp. including P. halstedii, P. viticola, Pleospora spp.), Podosphaera spp. including apple powdery mildew (P. leucotricha), Polymyxa graminis, Polymyxa betae, Pseudocercosporella herpotrichoides, Pseudomonas spp., Pseudoperonospora spp. including P. cubensis and P. humuli, and Pseudopezizatrakeiphila Puccinia spp. including P. tracheiphila, P. hordei, P. recondita, P. striiformis, P. triticina, Pyrenopeziza spp., Pyrenophora spp., Pyricularia spp. including P. oryzae, Pythium spp. including P. ultimum, Ramularia spp., Rhizoctonia spp., Rhizomucor pusillus, Rhizopus arizus arrhizus, Rhynchosporium spp., Scedosporium spp. including S. apiospermum and S. prolificans, Schizothyrium pomi, Sclerotinia spp., Sclerotium spp., S. nodorum, S. tritici, S.Septoria spp. including (Septoria tritici), Sphaerotheca macularis, Sphaerotheca fusca (Sphaerotheca fuliginea), Sporothorix spp., Stagonospora nodorum, Stemphylium spp., Stereum hirsutum, Thanatephorus cucumeris, Thielaviopsis basicola, Tilletia spp. Trichoderma spp. including T. harzianum, T. pseudokoningii, and T. viride, Trichophyton spp., Typhula spp., Uncinula necator, Urocystis spp., Ustilago spp., and Venturia spp. including V. inaequalis.), Verticillium spp. and Xanthomonas spp., in particular Zymoseptoria tritici, Puccinia recondita, Puccinia striiformis, Erysiphe graminis, Uncinula necator, Sphaerotheca fuliginea, Leveillula taurica, Phakopsora pachyrhizi, Pyricularia oryzae, Alternaria solani, Alternaria alternata alternata, Mycosphaerella fijiensis, Colletotrichum lagenarium, Didymella bryoniae, Ascochyta pisii, Verticillium dahliae,. No cross-resistance has been observed between any fungicidal solution used to control plant pathogenic fungi such as Pyrenophora teres, Cercospora beticola, Ramularia collo-cygni, Botrytis cinerea, Sclerotinia sclerotiorum, Monilinia laxa, Monographaella nivalis, and Venturia inaequalis and a composition comprising a mixture of components (A) and (B).

[0293] Indeed, fungicide-resistant strains of any of the species outlined above have been reported in the scientific literature, where the strains are resistant to one or more fungicides according to at least one of the following fungicide mode of action classifications: quinone external inhibitors (QoIs), quinone internal inhibitors (QiIs), succinate dehydrogenase inhibitors (SDHIs), and sterol demethylation inhibitors (DMIs). Such fungicide-resistant strains may include: 1. Mutations in the mitochondrial cytochrome b gene that confer resistance to Qo inhibitors, where the mutation is G143A, F129L, or G137R. See, for example, Gisi et al., Pest Manag Sci. 2000, 56, 833-841; Lucas, Pestic Outlook 2003, 14(6), 268-70; Fraaije et al., Phytopathol 2005, 95(8), 933-41; Sierotzki et al., Pest Manag. Sci. 2007, 63(3), 225-233(2007); Semar et al., J. Plant Dis. Prot. 2007, (3), 117-119; and Pasche et al., J. Crop Prot. 2008, 27(3-5), 427-435(2008).

[0294] 2. A mutation in the mitochondrial cytochrome b gene that confers resistance to Qi inhibitors, where the mutation is G37A / C / D / S / V or N31K. See, for example, Meunier et al., Pest Manag Sci. 2019; 75: 2107-2114, Young et al., Pest Manag Sci. 2018; 74(2): 489-498, Walker et al., Environ. Microbiol. 2021 (https: / / doi.org / 10.1111 / 1462-2920.15760).

[0295] 3. Mutations in genes encoding the SdhB, C, D subunits that confer resistance to SDHI inhibitors, where the mutations are in the following major pathogens: Botrytis cinerea: B-P225H / L / T / Y / F, B-N230I, B-H272L / Y / R, C-P80H / L, C-N87S, Alternaria solani: B-H278R / Y, C-H134R / Q, D-D123E, D-H133R and C-H134R, Zymoseptoria tritici: sdhB: N225T, N225I, R265P, T268I, T268A. sdhC: T79N, T79I, W80S, W80A, A84F, N86S, N86A, P127A, R151M / S / T / G, R151S, R151T, H152R / Y, V166M, T168R. sdhD: I50F, M114V, D129G, T20P+K186R. Pyrenophora teres: in sdhB: S66P, N235I, H277Y. in sdhC: K49E, R64K, N75S, G79R, H134R, S135R. in sdhD: D124E, H134R, G138V, D145G. Ramularia collo-cygni: in sdhB: N224T, T267I. in sdhC: N87S, G91R, H146R / L, G171D, H153R. Phakopsora pachyrhizi: C-I86F, Sclerotinia sclerotiorum: in sdhB: H273Y. in sdhC: G91R, H146R. in sdhD: T108K, H132R, G150R.

[0296] The main sources of information are www.frac.info, Sierotzki and Scalliet Phytopathology (2013) 103(9):880-887 and Simoes et al., J Plant Dis Prot 2018, 125:21-2.

[0297] Mutations or combinations of mutations in the CYP51 gene that confer resistance to DMI inhibitors, including L50S, D134G, V136A / C, Y137F, S188N, A379G, I381V, deletions 459-460, Y461H / S, N513K, and S524T. Primary sources of information include www.frac.info, Cools et al., Plant Pathol. 2013, 62:36-42, and Schmitz HK et al., Pest Manag. Sci. 2014, 70:378-388.

[0298] Therefore, in a preferred embodiment, the composition according to the invention comprising a mixture of components (A) and (B) is used for controlling fungal strains that are resistant to one or more fungicides according to any of the following fungicidal MoA classifications: quinone external inhibitors (QoIs), quinone internal inhibitors (QiIs), succinate dehydrogenase inhibitors (SDHIs) and sterol demethylation inhibitors (DMIs).

[0299] The compositions of the present invention, including all of the above disclosed embodiments and preferred examples thereof, can be mixed with one or more additional pesticides, including additional fungicides, insecticides, nematicides, bactericides, miticides, growth regulators, sterilizers, signal chemicals, repellents, attractants, pheromones, feeding stimulants or other biologically active compounds, to form multi-component pesticides that provide even broader agricultural protection.

[0300] Examples of such agricultural protection agents that can be formulated with the compositions of the present invention are: etridiazole, fluazinam, benalaxyl, benalaxyl-M (chiralaxyl), furalaxyl, metalaxyl, metalaxyl-M (mefenoxam), dodisin, N'-(2,5-dimethyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine, N'-[4-(4,5-dichloro-thiazol-2-yloxy)-2,5-dimethyl-phenyl]-N -Ethyl-N-methyl-formamidine, N'-[4-[[3-[(4-chlorophenyl)methyl]-1,2,4-thiadiazol-5-yl]oxy]-2,5-dimethyl-phenyl]-N-ethyl-N-methyl-formamidine, ethirimol, 3'-chloro-2-methoxy-N-[(3RS)-tetrahydro-2-oxofuran-3-yl]aceto-2',6'-xylidide (clozylacon), cyprodinil, mepanipyrim, pyrimethanil, dithianon, aureofungin phenanthrene, blasticidin-S, biphenyl, chloroneb, dicloran, benzovindiflupyr, pydiflumetofen, hexachlorobenzene, quintozene, tecnazene (TCNB), tolclofos-methyl, metrafenone, 2,6-dichloro-N-(4-trifluoromethylbenzyl)-benzamide, fluopicolide (flupicolide), thiximide, flusulfamide, benomyl, carbendazim, carbendazim chlorhydrate, chlorphenazole, fuberidazole , thiabendazole, thiophanate-methyl, benthiavalicarb, clobenthiazone, probenazole, acibenzolar, bethoxadin, pyriophenone (IKF-309), acibenzolar-S-methyl, pyribencarb (KIF-7767), butylamine, 3-iodo-2-propynyl n-butylcarbamate (IPBC), picarbutrazox, polycarbamate, propamocarb, tolprocarb, 3-(difluoromethyl)-N-(7-fluoro-1,1,3,3-Tetramethyl-indan-4-yl)-1-methyl-pyrazole-4-carboxamide, diclocymet, N-[(5-chloro-2-isopropyl-phenyl)methyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-pyrazole-4-carboxamide, N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-[(2-isopropylphenyl)methyl]-1-methyl-pyrazole-4-carboxamide, carpropamid, chlorothalonil, flumorph, oxine-copper, cymoxanil, fenamacril, cyazofamid, fluthianil, thiciophen, chlozolinate, iprodione, procymidone, vinclozolin, bupirimate, dinoctone, dinopenton, dinobutone, dinocap, meptyldinocap, diphen Nilamine, phosdifen, 2,6-dimethyl-[1,4]dithiino[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetraone, azithiram, ethem, ferbam, mancozeb, maneb, metham, metiram (polyram), metiram-zinc, narbam, propineb, thiram, bapam (metam sodium), zineb, ziram, dithioether, isoprothiola methicone, ethaboxam, fosetyl, fosetyl-Al (fosetyl-al), methyl bromide, methyl iodide, methyl isothiocyanate, cyclafuramide, fenfuram, validamycin, streptomycin, (2RS)-2-bromo-2-(bromomethyl)glutaronitrile (bromothalonil), dodine, dogudine, guazatine, iminoctadine, iminoctadine triacetate, 2,4-D, 2,4-DB, kasugamycin, dimethirimol, fenhexamid, hymexazole, hydroxyisoxazole, imazalil, imazalil sulfate, oxypoconazole, pefurazoate, prochloraz, triflumizole, fenamidone, Bordeaux mixture, calcium polysulfide, copper acetate, copper carbonate, copper hydroxide, copper naphthenate, copper oleate, copper oxychloride, copper oxyquinolate, copper silicate, copper sulfate, copper thalate, cuprous oxide, sulfur, carbaryl, phthalide, Jun Si Qi), oxathiapiproline, fluoroimide, mandipropamid, KSF-1002, benzam- ph, dimethomorph, fenpropimorph, tridemorph, dodemorph, diethofencarb, triphenyltin acetate, triphenyltin hydroxide, carboxin, oxycarboxin, drazoxolone, famoxadone, m-phenylphenol, p-phenylphenol, tribromophenol (TBP), 2-[2-[(7,8-difluoro-2-methyl-3-quinolyl)oxy]-6-fluoro-phenyl]propan-2-ol, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3-quinolyl)oxy]phenyl]propan-2-ol, cyflufenamid, oflac, oxadixyl, flutolanil, mepronil, isofetamide, fenpiclonil, fludioxonil, pencycuron, edifenphos, iprobe Amphos, pyrazophos, phosphoric acid, tecloftalam, captafol, captan, ditalimfos, triforine, fenpropidin, piperalin, osthole, 1-methylcyclopropene, 4-CPA, chlormequat, clofencet, dichlorprop, dimethipin, endothall, ethephon, flumetralin, forchlorfenuron, gibberellic acid, gibberellin, hymexazol, maleic hydrazide, mepicor Naphthaleneacetamide, Paclobutrazol, Prohexadione, Prohexadione-Calcium, Thidiazuron, Tribufos (Tributylphosphorotrithioate), Trinexapac, Uniconazole, α-Naphthaleneacetic Acid, Polyoxin D (Polyoxylim), BLAD, Chitosan, Fenoxanil, Folpet, 3-(Difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2-(2,4,6-trichlorophenyl)ethyl]pyrazole-4-carboxamide, bixafen, fluxapyroxad, furametpyr, isopyrazam, penflufen, penthiopyrad, sedaxane, fenpyrazamine, diclomedine, pyrifenox, boscalid, fluopyram, diflumetrim, fenarimol, 5-fluoro-2-(p-tolylmethoxy)pyrimidin-4-amine, ferimzone, dimethaclone (dimethaclone), pyroquilon, proquinazide, ethoxyquin, quinoxyfen, 4, 4,5-trifluoro-3,3-dimethyl-1-(3-quinolyl)isoquinoline, 4,4-difluoro-3,3-dimethyl-1-(3-quinolyl)isoquinoline, 5-fluoro-3,3,4,4-tetramethyl-1-(3-quinolyl)isoquinoline, 9-fluoro-2,2-dimethyl-5-(3-quinolyl)-3H-1,4-benzoxazepine, tebufloquine, oxolinic acid, quinomethionate (oxythioquinox, quinoxymethionate), spiroxamine, (E)-N-methyl-2-[2-(2,5-dimethylphenoxymethyl)phenyl]-2- Methoxy-iminoacetamide, azoxystrobin, cumoxystrobin, dimoxystrobin, enesterobrine, enoxastrobin, fenamistrobin, flufenoxystrobin, fluoxastrobin, kresoxim-methyl, mandestrobin, metaminostrobin, metominostrobin, oryzastrobin, picoxystrobin, pyraclostrobin, pyrametostrobin, pyraoxystrobin, triclopyricarb, trifloxystrobin, amisulbrom, dichlofluanid, tolylfluanid, but-3-ynyl N-[6-[ [(Z)-[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate, dazomet, isotianil, tiadinil, thifluzamide, benzazole (TCMTB), silthiofam, zoxamide, anilazine, tricyclazole, (rac)-cis-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)-cycloheptanol (Fangjunzuo), 1-(5-bromo-2-pyridyl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1,2,4-Triazol-1-yl)propan-2-ol, 2-(1-tert-butyl)-1-(2-chlorophenyl)-3-(1,2,4-triazol-1-yl)-propan-2-ol (TCDP), azaconazole, bitertanol (viloxazole), bromuconazole, climbazole, cyproconazole, difenoconazole, dimetconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole , fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, ipfentrifluconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triazoxide, triticonazole, mefentrifluconazole, 2-[[ (1R,5S)-5-[(4-fluorophenyl)methyl]-1-hydroxy-2,2-dimethyl-cyclopentyl]methyl]-4H-1,2,4-triazole-3-thione, 2-[[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl]-4H-1,2,4-triazole-3-thione, ametoctrazine (imidium), iprovalicarb, valifenalate, 2-benzyl-4-chlorophenyl Fungicides such as phenol (chlorophen), allyl alcohol, azafenidin, benzalkonium chloride, chloropicrin, cresol, dalacid, dichlorophen (dichlorophene), difenzoquat, dipyrithione, N-(2-p-chlorobenzoylethyl)-hexaminium chloride, NNF-0721, octhilinone, oxasulfuron, propamidine, and propionic acid.

[0301] Abamectin, acephate, acetamiprid, amidoflumet (S-1955), avermectin, azadirachtin, azinphos-methyl, bifenthrin, vinphenazate, buprofezin, carbofuran, cartap, chlorantraniliprole (DPX-E2Y45), chlorfenapyr, chlorfluazuron, chlorpyrifos, chlorpyrifos-methyl, chromafenozide, clothianidin, cyflumetofen, cyfluthrin, β-cysteine Fluthrin, cyhalothrin, λ-cyhalothrin, cypermethrin, cyromazine, deltamethrin, diafenthiuron, diazinon, dieldrin, diflubenzuron, dimefluthrin, dimethoate, dinotefuran, diofenolan, emamectin, endosulfan, esfenvalerate, ethiprole, fenothiocarb, fenoxycarb, fenpropathrin, fenvalerate, fipronil, flonicamid, flubendiamide, Lucithrinate, tau-fluvalinate, flufenerim (UR-50701), flufenoxuron, fonofos, halofenozide, hexaflumuron, hydramethylnon, imidacloprid, indoxacarb, isofenphos, lufenuron, malathion, metaflumizone, metaldehyde, methamidophos, methidathion, methomyl, methoprene, methoxychlor, metofluthrin, monocrotophos, methoxyfenozide, nitenpyram, and Nichia insecticides such as gin, novaluron, noviflumuron (XDE-007), oxamyl, parathion, parathion-methyl, permethrin, phorate, phosalone, phosmet, phosphamidon, pirimicarb, profenofos, profluthrin, pymetrozine, pyrafluprole, pyrethrins, pyridalyl, pyrifluquinazon, pyriprole, pyriproxyfen, rotenone, ryanodine, spinetoram, spinosad, spirodiclofen, spiromesifen (BSN 2060), spirotetramat, sulprofos, tebufenozide, teflubenzuron, terftrin, terbufos, tetrachlorvinphos, thiacloprid, thiamethoxam, thiodicarb, thiosultap-sodium, tralomethrin, triazamate, trichlorfon and triflumuron; Bactericides such as streptomycin, Acaricides such as amitraz, quinomethionate, chlorobenzilate, cyenopyrafen, cyhexatin, dicofol, dienochlor, etoxazole, fenazaquin, fenbutatin oxide, fenpropathrin, fenpyroximate, hexythiazox, propargite, pyridaben and tebufenpyrad, and Biological agents such as Bacillus thuringiensis, Bacillus thuringiensis delta-endotoxin, baculovirus and entomopathogenic bacteria, viruses and fungi.

[0302] Other examples of "reference" mixture compositions are as follows (the term "TX" refers to compound numbers (X.01), (X.02), (X.03), (X.04), (X.05), (X.06), (X.07), (X.08), (X.9), (X.10), (X.11), (X.12), (X.13), (X.14), (X.15), (X.16), (X.17), (X.18), (X.19), (X.20), (X.21), (X.22), (X.23), (X.24), (X.25), (X.26), (X.27), (X.28) or as defined in Table X above): (X.29) represents a compound (according to the definition of component (A) of the composition of the present invention) selected from the group consisting of: petroleum + TX, 1,1-bis(4-chlorophenyl)-2-ethoxyethanol + TX, 2,4-dichlorophenylbenzenesulfonate + TX, 2-fluoro-N-methyl-N-1-naphthylacetamide + TX, 4-chlorophenylphenylsulfone + TX, acetoprole + TX, aldoxicarb + TX, amidithione + TX, amidothioate + TX, amiton + TX, amiton hydrogen oxalate + TX, amiton Raz + TX, Aramite + TX, Arsenic trioxide + TX, Azobenzene + TX, Azotoate + TX, Benomyl + TX, Benoxafos + TX, Benzyl benzoate + TX, Bixafen + TX, Brofenvalerate + TX, Bromocyclen + TX, Bromophos + TX, Bromopropylate + TX, Buprofezin + TX, Butocarboxim + TX, Butoxycarboxim + TX, Butylpyridaben + TX, Calcium polysulfide + TX, Camphechlor + TX, Carbanolate + TX, Carbophenothion + TX, Cimiazole + TX, Chinomethionate + TX, Chlorbeneside +TX, chlordimeform +TX, chlordimeform hydrochloride +TX, chlorphenetole +TX, chlorfenson +TX, chlorfensulfide +TX, chlorobenzilate +TX, chlormebform +TX, chloromethiuron +TX, chloropropylate +TX, chlorthiophos +TX, cinerin I +TX, cinerin II +TX, cinerin +TX, closantel +TX, coumaphos +TX, crotamiton +TX, crotoxyphos +TX, khuraneb +TX, cyanthoate +TX, DCPM +TX, DDT +TX, demefion +TX,Demefion-O+TX, Demefion-S+TX, Demeton-methyl+TX, Demeton-O+TX, Demeton-O-methyl+TX, Demeton-S+TX, Demeton-S-methyl+TX, Demeton-S-methylsulfone+TX, Dichlofluanid+TX, Dichlorvos+TX, Dicrifos+TX, Dienochlor+TX, Dimefox+TX, Zinex+TX, Zinex-Diclexin+TX, Dinocap-4+TX, Dinocap-6+TX, Dinocton+TX, Dinopenton+TX, Dinosulfone+TX, Dinotervon+TX, Dioxathion +TX, diphenylsulfone +TX, disulfiram +TX, DNOC +TX, dofenapine +TX, doramectin +TX, endothion +TX, eprinomectin +TX, ethoate-methyl +TX, etrimphos +TX, fenazaflor +TX, fenbutatin oxide +TX, fenothiocarb +TX, fenpyrad +TX, fenpyroximate +TX, fenpyrazamine +TX, fenson +TX, fentrifanil +TX, flubenzimine +TX, flucycloxuron +TX, fluenethyl +TX, fluorbenside +TX, FMC 1137+TX, formetanate+TX, formetanate hydrochloride+TX, formparanate+TX, γ-HCH+TX, gliodin+TX, halfenprox+TX, hexadecylcyclopropanecarboxylate+TX, isocarbophos+TX, jasmolin I+TX, jasmolin II+TX, iodofenphos+TX, lindane+TX, malonoven+TX, mecarbam+TX, mefosfolan+TX, mesulfen+TX, methacrifos+TX, methyl bromide+TX, metolcarb+TX, mexacarbate+TX, milbemycin oxime+TX, mipaphos ox + TX, monocrotophos + TX, morphothion + TX, moxidectin + TX, naled + TX, 4-chloro-2-(2-chloro-2-methyl-propyl)-5-[(6-iodo-3-pyridyl)methoxy]pyridazin-3-one + TX, nifururidide + TX, nikkomycin + TX, nitrilacarb + TX, nitrilacarb 1:1 zinc chloride complex + TX, omethoate + TX, oxydeprophos + TX, oxydisulfoton + TX, pp'-DDT + TX, parathion + TX, permethrin + TX, fencapton + TX, phosalone + TX, phospholan + TX,Phosphamidon +TX, Polychloroterpene +TX, Polynactin +TX, Proclonol +TX, Promacyl +TX, Propoxar +TX, Protidathion +TX, Protoate +TX, Pyrethrin I +TX, Pyrethrin II +TX, Pyrethrin +TX, Pyridaphenthion +TX, Pirimitate +TX, Quinalphos +TX, Quinthiox +TX, R-1492 +TX, Phosglycine +TX, Rotenone +TX, Schradan +TX, Cebufos +TX, Selamectin +TX, Sofamid +TX, SSI-121 +TX, Sulfiram +TX, Sulfuramin Do + TX, Sulfotep + TX, Sulfur + TX, Diflobidazin + TX, τ-Fulvalinate + TX, TEPP + TX, Thelbam + TX, Tetradifon + TX, Tetrasulf + TX, Thiafenox + TX, Thiocarboxim + TX, Thiofanox + TX, Thiometon + TX, Thioquinox + TX, Thuringiensin + TX, Triamiphos + TX, Triatene + TX, Triazophos + TX, Triazuron + TX, Trifenofos + TX, Trinactin + TX, Vamidothion + TX, Vaniliprole + TX, Bethoxadin + TX, Copper dioctanoate + TX , Copper sulfate + TX, Sibutrin + TX, Dichlorne + TX, Dichlorophen + TX, Endothal + TX, Fentin + TX, Slaked lime + TX, Nabam + TX, Quinoclamine + TX, Quinonamide + TX, Simazine + TX, Triphenyltin acetate + TX, Triphenyltin hydroxide + TX, Crufomate + TX, Piperazine + TX, Thiophanate + TX, Chloralose + TX, Fenthion + TX, Pyridin-4-amine + TX, Strychnine + TX, 1-Hydroxy-1H-pyridine-2-thione + TX, 4-(quinoxalin-2-ylamino)benzenesulfonate Sulfonamide +TX, 8-hydroxyquinoline sulfate +TX, Bronopol +TX, Copper hydroxide +TX, Cresol +TX, Dipyrithione +TX, Dodisin +TX, Fenaminosulf +TX, Formaldehyde +TX, Hydralgafen +TX, Kasugamycin +TX, Kasugamycin hydrochloride hydrate +TX, Nickel bis(dimethyldithiocarbamate) +TX, Nitrapyrin +TX, Octilinone +TX, Oxolinic acid +TX, Oxytetracycline +TX, Hydroxyquinoline potassium sulfate +TX, Probenazole +TX, Streptomycin +TX,Streptomycin sesquisulfate + TX, tecloftalam + TX, thiomersal + TX, Adoxophyes orana GV + TX, Agrobacterium radiobacter + TX, Amblyseius spp. + TX, Anagrapha falcifera NPV + TX, Anagrus atomus + TX, Aphelinus abdominalis + TX, Aphidius colemani + TX, Aphidoletes aphidimyza + TX, Autographa californica NPV + TX, Bacillus sphaericus Neide + TX, Beauveria brongniartii + TX, Chrysoperla carnea + TX, Cryptolaemus montrouzieri + TX, Codling moth (Cydia pomonella) GV + TX, Leaf-staring wasp (Dacnusa sibirica) + TX, Diglyphus isaea + TX, Encarsia formosa + TX, Desert wasp (Eretmocerus eremicus) + TX, Heterorhabditis bacteriophora and H. megidis + TX, Hippodamia convergens) + TX, Fujikonahigelongagatobikobai (Leptomastix dactylopii) + TX, Macrolophus caliginosus + TX, Armyworm moth (Mamestra brassicae) NPV + TX, Metaphycus helvolus + TX,Metarhizium anisopliae var. acridum + TX, Metarhizium anisopliae var. anisopliae + TX, Neodiprion sertifer NPV and N. lecontei NPV + TX, Orius spp. + TX, Paecilomyces fumosoroseus + TX, Phytoseiulus persimilis + TX, Steinernema bibionis + TX, Steinernema carpocapsae + TX carpocapsae + TX, Steinernema feltiae + TX, Steinernema glaseri + TX, Steinernema riobrave + TX, Steinernema riobravis + TX, Steinernema scapterisci + TX, Steinernema spp. + TX, Trichogramma spp. + TX, Typhlodromus occidentalis + TX, Verticillium lecanii) + TX, apholate + TX, Visadil + TX, busulfan + TX, Dimatif + TX, Hemel + TX, Hempa + TX, Metepa + TX, Methiotepa + TX, methyl apholate + TX, Molzide + TX, Penfluron + TX, Tepa + TX, Thiohempa + TX, Thiotepa + TX, Tretamine + TX, Uredepa + TX, (E)-dec-5-en-1-yl acetate and (E)-dec-5-en-1-ol + TX, (E)-tridec-4-en-1-yl acetate + TX, (E)-6-methylhept-2-en-4-ol + TX, (E,Z)-tetradec-4,10-dien-1-yl acetate + TX,(Z)-Dodec-7-en-1-yl acetate + TX, (Z)-hexadec-11-enal + TX, (Z)-hexadec-11-en-1-yl acetate + TX, (Z)-hexadec-13-en-11-yn-1-yl acetate + TX, (Z)-icosa-13-en-10-one + TX, (Z)-tetradec-7-en-1-al + TX, (Z)-tetradec-9-en-1-ol + TX, (Z)-Tetradeca-9-en-1-yl acetate + TX, (7E,9Z)-dodeca-7,9-dien-1-yl acetate + TX, (9Z,11E)-tetradeca-9,11-dien-1-yl acetate + TX, (9Z,12E)-tetradeca-9,12-dien-1-yl acetate + TX, 14-methyloctadec-1-ene + TX, 4-methylnonan-5-ol and 4-methylnonan-5-one + TX, α-multistriatin + TX, Brevicomin + TX, Codrelure + TX, Codlemone + TX, Curure + TX, Disparlure + TX, Dodec-8-en-1-yl acetate + TX, Dodec-9-en-1-yl acetate + TX, Dodeca-8,10-dien-1-yl acetate + TX, Dominicalure + TX, Ethyl 4-methyloctanoate + TX, Eugenol + TX, Frontalin + TX, Grandlure + TX, Grandlure I + TX, Grandlure II + TX, Grandlure III + TX, Grandlure IV + TX, Hexalure + TX, Ipsdienol + TX, Ipsenol + TX, Japonilure + TX, Lineatin + TX, Littlea + TX, Looplure + TX, Me Dolure + TX, Megatomoic acid + TX, Methyleugenol + TX, Muscalure + TX, Octadeca-2,13-dien-1-yl acetate + TX, Octadeca-3,13-dien-1-yl acetate + TX, Olfuralure + TX, Orictalure + TX, Ostramon + TX, Siglua + TX, Soldigin + TX, Sulcatol + TX, Tetradec-11-en-1-yl acetate + TX, Trimedulure + TX, Trimedulure A + TX, Trimedulure B1 + TX, Trimedulure B2 + TX, Trimedulure C + TX, Trunkol + TX, 2-(Oc (ethylthio)-ethanol + TX, butopyronoxyl + TX, butoxy (polypropylene glycol) + TX, dibutyl adipate + TX, dibutyl phthalate + TX, dibutyl succinate + TX, diethyltoluamide + TX, dimethylcarbate + TX, dimethyl phthalate + TX, ethyl hexanediol + TX, hexamide + TX, methoquin-butyl + TX, methyl neodecaneamide + TX, oxamate + TX, picaridin + TX, 1-dichloro-1-nitroethane + TX, 1,1-dichloro-2,2-bis(4-ethylphenyl)-ethane + TX,1,2-Dichloropropane and 1,3-dichloropropene + TX, 1-bromo-2-chloroethane + TX, 2,2,2-trichloro-1-(3,4-dichlorophenyl)ethyl acetate + TX, 2,2-dichlorovinyl 2-ethylsulfinylethyl methyl phosphate + TX, 2-(1,3-dithiolan-2-yl)phenyl dimethyl carbamate + TX, 2-(2-butoxyethoxy)ethyl thiocyanate + TX, 2-(4,5-dimethyl-1,3-dioxolan-2-yl)phenyl methyl carbamate + TX, 2-(4-chloro-3,5-xylyloxy)ethanol + TX, 2-chlorovinyl diethyl phosphate + TX, 2-imidazolidone + TX, 2-isovalerylindan-1,3-dione + TX, 2-methyl (Prop-2-ynyl)aminophenylmethylcarbamate + TX, 2-thiocyanatoethyl laurate + TX, 3-bromo-1-chloroprop-1-ene + TX, 3-methyl-1-phenylpyrazol-5-yldimethylcarbamate + TX, 4-methyl(prop-2-ynyl)amino-3,5-xylylmethylcarbamate + TX, 5,5-dimethyl-3-oxocyclohex-1-enyldimethylcarbamate + TX, acetione + TX, acrylonitrile + TX, aldrin + TX, allosamidin + TX, alixycarb + TX, α-ecdysone + TX, aluminum phosphide + TX, aminocarb + TX, anabasine + TX, atidathion + TX, azamethiphos + TX, Bacillus thuringiensis (Bacillus thuringiensis) delta endotoxin +TX, barium hexafluorosilicate +TX, barium polysulfide +TX, bartholin +TX, Bayer 22 / 190 +TX, Bayer 22408 +TX, β-cyfluthrin +TX, β-cypermethrin +TX, bioethanomethrin +TX, biopermethrin +TX, bis(2-chloroethyl) ether +TX, borax +TX, bromfenvinphos +TX, bromo-DDT +TX, bufencarb +TX, butacarb +TX, butathiophos +TX, butonate +TX, calcium arsenate +TX, calcium cyanide +TX, carbon disulfide +TX, carbon tetrachloride +TX, cartap hydrochloride +TX, sevadin +TX, chlorbicyclen +TX, chlordane +TX, chlordecone +TX, chloroform +TX,Chloropicrin + TX, chlorphoxim + TX, chlorprazophos + TX, cis-resmethrin + TX, cismethrin + TX, clocitrin + TX, copper acetoarsenite + TX, copper arsenate + TX, copper oleate + TX, chumithoate + TX, cryolite + TX, CS 708+TX, cyanofenphos+TX, cyanophos+TX, cyclethrin+TX, cythioate+TX, d-tetramethrin+TX, DAEP+TX, dazomet+TX, decarbofuran+TX, diamidaphos+TX, dikapton+TX, diclofenthion+TX, dicresyl+TX, dicyclanil+TX, dieldrin+TX, diethyl 5-methylpyrazol-3-yl phosphate+TX, dilol+TX, dimefluthrin+TX, dimethane+TX, dimethryn+TX, dimethylvinphos+TX, dimethyllan+TX, dinoprop+TX, dinosam+TX, dinoseb+TX, diofenolan+TX, dioxabenzophos+TX, dicyclophos+TX, DSP+TX, ecdysterone+TX, EI 1642+TX, EMPC+TX, EPBP+TX, Ethiaphos+TX, Ethiofencarb+TX, Ethyl formate+TX, Ethylene dibromide+TX, Ethylene dichloride+TX, Ethylene oxide+TX, EXD+TX, Fenchlorphos+TX, Fenetacarb+TX, Fenitrothion+TX, Fenoxacrim+TX, Fenpyrithrin+TX, Fensulfothion+TX, Fenthion-ethyl+TX, Flucofuron+TX, Fosmetilan+TX, Fospirate+TX, Fostietan+TX, Furathiocarb+TX, Frethrin+TX, Guazatine+TX, Guazatine acetate+TX, Sodium tetrathiocarbonate+TX, Half Enprox + TX, HCH + TX, HEOD + TX, Heptachlor + TX, Heterofos + TX, HHDN + TX, Hydrogen cyanide + TX, Hikincarb + TX, IPSP + TX, Isazophos + TX, Isobenzane + TX, Isodrin + TX, Isofenphos + TX, Isolane + TX, Isoprothiolane + TX, Isoxathion + TX, Juvenile hormone I + TX, Juvenile hormone II + TX, Juvenile hormone III + TX, Kelevan + TX, Kinoprene + TX, Lead arsenate + TX, Leptophos + TX, Lilimphos + TX, Ritidathion + TX, m-Cumenylmethylcarbamate + TX, Magnesium phosphide + TX, Magidox + TX,Mecarfone + TX, Menasone + TX, Mercurous Chloride + TX, Mesulfenphos + TX, Metam + TX, Metam-Potassium + TX, Metam-Sodium + TX, Methanesulfonyl Fluoride + TX, Metocrotophos + TX, Methoprene + TX, Methotrin + TX, Methoxychlor + TX, Methyl Isothiocyanate + TX, Methyl Chloroform + TX, Methylene Chloride + TX, Methoxadiazone + TX, Mirex + TX, Naphthalophos + TX, Naphthalene + TX, NC-170 + TX, Nicotine + TX, Nicotine Sulfate + TX, Nithiazine + TX, No Ilnicotine + TX, O-5-dichloro-4-iodophenyl O-ethyl ethylphosphonothioate + TX, O,O-diethyl O-4-methyl-2-oxo-2H-chromen-7-yl phosphorothioate + TX, O,O-diethyl O-6-methyl-2-propylpyrimidin-4-yl phosphorothioate + TX, O,O,O',O'-tetrapropyl dithiopyrophosphate + TX, oleic acid + TX, para-dichlorobenzene + TX, parathion-methyl + TX, pentachlorophenol + TX, pentachlorophenyl laurate + TX, PH 60-38 + TX, Fenkapton + TX, Fosniclor + TX, Phosphine + TX, Phoxim-methyl + TX, Pyrimetaphos + TX, Polychlorodicyclopentadiene Isomers + TX, Potassium Arsenite + TX, Potassium Thiocyanate + TX, Precocene I + TX, Precocene II + TX, Precocene III + TX, Primidophos + TX, Profluthrin + TX, Promecarb + TX, Prothiofos + TX, Pyrazophos + TX, Pyresmethrin + TX, Quassia + TX, Quinalphos-methyl + TX, Quinothione + TX, Rafoxanide + TX, Resmethrin + TX , Rotenone + TX, Kadetrin + TX, Riania + TX, Ryanodine + TX, Sabadila + TX, Schradan + TX, Cebufos + TX, SI-0009 + TX, Tiapronil + TX, Sodium arsenite + TX, Sodium cyanide + TX, Sodium fluoride + TX, Sodium hexafluorosilicate + TX, Sodium pentachlorophenoxide + TX, Sodium selenate + TX, Sodium thiocyanate + TX, Sulcofuron + TX, Sulcofuron-sodium + TX, Sulfuryl fluoride + TX, Sulproos + TX, Tar oil + TX, Tadimcarb + TX,TDE+TX, tebupirimfos+TX, temephos+TX, telalethrin+TX, tetrachloroethane+TX, cyclofos+TX, thiocyclam+TX, thiocyclam hydrogen oxalate+TX, thionazine+TX, thiosultap+TX, thiosultap-sodium+TX, tralomethrin+TX, transpermethrin+TX, triazamate+TX, trichlormethaphos-3+TX, trichloronate+TX, trimethacarb+TX, tolprocarb+TX, triclopiricarb+TX, triplenone+TX, veratridine+TX, veratrine+TX, XMC+TX, zetamethrin+TX, zinc phosphide+TX, zolaprofos+TX, meperfluthrin+TX, tetramethylfluthrin+TX, bis(tributyltin) oxide + TX, bromoacetamide + TX, ferric phosphate + TX, niclosamide-olamine + TX, tributyltin oxide + TX, pyrimorph + TX, triphenmorph + TX, 1,2-dibromo-3-chloropropane + TX, 1,3-dichloropropene + TX, 3,4-dichlorotetrahydrothiophene 1,1-dioxide + TX, 3-(4-chlorophenyl)-5-methylrhodanine + TX, 5-methyl-6-thioxo-1,3,5-thiadiazinan-3-ylacetic acid + TX, 6-isopentenylaminopurine + TX, anicifluprine + TX, benclothiaz + TX, cytokinin + TX, DCIP + TX, furfural + TX, isamidophos + TX, kinetin + TX, mulberry dark spot fungus (Myrothecium verrucaria) composition +TX, tetrachlorothiophene +TX, xylenol +TX, zeatin +TX, potassium ethylxanthate +TX, acibenzolar +TX, acibenzolar-S-methyl +TX, giant knotweed (Reynoutria sachalinensis) extract +TX, α-chlorohydrin +TX, anth +TX, barium carbonate +TX, bisthiosemi +TX, brodifacoum +TX, bromadiolone +TX, bromethalin +TX, chlorophacinone +TX, cholecalciferol +TX, coumachlor +TX, coumafuryl +TX, coumatetralyl +TX, crimidine +TX, difenacoum +TX, difethialone +TX, diphacinone +TX, ergocalciferol +TX, flocoumafen +TX, fluoroacetamide +TX,Flupropazine + TX, flupropazine hydrochloride + TX, norbormide + TX, fosacetim + TX, phosphorus + TX, pindone + TX, pyrinuron + TX, sciliroside + TX, sodium -fluoroacetate + TX, thallium sulfate + TX, warfarin + TX, -2-(2-butoxyethoxy)ethyl piperonylate + TX, 5-(1,3-Benzodioxol-5-yl)-3-hexylcyclohex-2-enone + TX, Farnesol and Nerolidol + TX, Verbutin + TX, MGK 264 + TX, Piperonyl butoxide + TX, Piprotal + TX, Propyl isomers + TX, S421 + TX, Sesamex + TX, Sesamolin + TX, Sulfoxide + TX, Anthraquinone + TX, Copper naphthenate + TX, Copper oxychloride + TX, Dicyclopentadiene + TX, Thiram + TX, Zinc naphthenate + TX, Ziram + TX, Imanin + TX, Ribavirin + TX, Chlorinconazide + TX, Mercuric oxide + TX, Thiophanate-methyl + TX, Azaconazole + TX, Bitertanol + TX, Bromuconazo ol + TX, cyproconazole + TX, difenoconazole + TX, diniconazole + TX, epoxiconazole + TX, fenbuconazole + TX, fluquinconazole + TX, flusilazole + TX, flutriafol + TX, furametpyr + TX, hexaconazole + TX, imazalil + TX, imibenconazole + TX, ipconazole + TX, metconazole + TX, myclobutanil + TX, paclobutrazol + TX, pefurazoate + TX, penconazole + TX, prothioconazole + TX , Pyrifenox +TX, Prochloraz +TX, Propiconazole +TX, Pyrisoxazole +TX, -Simeconazole +TX, Tebuconazole +TX, Tetraconazole +TX, Triadimefon +TX, Triadimenol +TX, Triflumizole +TX, Triticonazole +TX, Ancymidol +TX, Fenarimol +TX, Nuarimol +TX, Bupirimate +TX, Dimethirimol +TX, Ethirimol +TX, Dodemorph +TX, Fenpropidin +TX, Fenpropimorph +TX, Spiroxamine methicone + TX, tridemorph + TX, cyprodinil + TX, mepanipyrim + TX, pyrimethanil + TX, fenpiclonil + TX, fludioxonil + TX, benalaxyl + TX, furalaxyl + TX, -metalaxyl- + TX, metalaxyl-M + TX, ofrace + TX, oxadixyl + TX, carbendazim + TX, debacarb + TX, fuberidazole + TX, thiabendazole + TX, chlozolinate + TX, dichlozolin + TX, mycozolin + TX, procymidone + TX, vinclozolin + TX,Boscalid + TX, Carboxin + TX, Fenfuram + TX, Flutolanil + TX, Mepronil + TX, Oxycarboxin + TX, Penthiopyrad + TX, Thifluzamide + TX, Dodine + TX, Iminoctadine + TX, Azoxystrobin + TX, Dimoxystrobin + TX, Enesterobrine + TX, Phenaminestrobin + TX, Flufenoxystrobin + TX, Fluoxastrobin + TX, Kresoxim-methyl + TX, Metominostrobin + TX, Trifloxystrobin + TX, Oryzastrobin + TX, Picoxystrobin + TX , pyraclostrobin +TX, pyrametostrobin +TX, pyraoxystrobin +TX, ferbam +TX, mancozeb +TX, maneb +TX, metiram +TX, propineb +TX, zineb +TX, captafol +TX, captan +TX, fluoroimide +TX, folpet +TX, tolylfluanid +TX, Bordeaux mixture +TX, copper oxide +TX, mancopper +TX, oxine-copper +TX, nitrotar-isopropyl +TX, edifenphos +TX, iprobenfos +TX, phosdifen +TX, tolclofos-methyl +TX, anilazine +TX, be Antivalicarb +TX, Blasticidin-S +TX, Chloroneb +TX, Chlorothalonil +TX, Cyflufenamid +TX, Cymoxanil +TX, Cyclobutrifluram +TX, Diclocymet +TX, Diclomedine +TX, Dicloran +TX, Diethofencarb +TX, Dimethomorph +TX, Flumorph +TX, Dithianon +TX, Ethaboxam +TX, Etridiazole +TX, Famoxadone +TX, Fenamidone +TX, Fenoxanil +TX, Ferimzone +TX, Fluazinam +TX, Flumethylsulfolim +TX, Fluopicolide +TX, fluoxythioconazole +TX, flusulfamide +TX, fluxapyroxad +TX, -fenhexamid +TX, fosetyl-aluminum +TX, hymexazole +TX, iprovalicarb +TX, cyazofamid +TX, methasulfocarb +TX, metrafenone +TX, pencycuron +TX, phthalide +TX, polyoxin +TX, propamocarb +TX, pyribencarb +TX, proquinazid +TX, pyroquilon +TX, pyriophenone +TX, quinoxyfen +TX, quintozene +TX, tiadinil +TX, triazoxide +TX,Tricyclazole + TX, triforine + TX, validamycin + TX, valifenalate + TX, zoxamide + TX, mandipropamide + TX, fluveneteram + TX, isopyrazam + TX, sedaxane + TX, benzovindiflupyr + TX, pydiflumetofen + TX, 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3',4',5'-trifluoro-biphenyl-2-yl)-amide + TX, isoflucipram + TX, isotianil + TX, dipimethitrone + TX, 6-ethyl-5,7-dioxo-pyrrolo[4,5][1, 4]dithiino[1,2-c]isothiazole-3-carbonitrile + TX, 2-(difluoromethyl)-N-[3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX, 4-(2,6-difluorophenyl)-6-methyl-5-phenyl-pyridazine-3-carbonitrile + TX, (R)-3-(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide + TX, 4-(2-bromo-4-fluoro-phenyl)-N-(2-chloro-6-fluoro-phenyl)pyridine-3-carbonitrile + TX (2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazol-5-amine + TX, fluindapyr + TX, methoxystrobin (Jia Xiangchunzi) + TX, rubenmixianan + TX, diclobenthiazox + TX, mandestrobin + TX, 3-(4,4-difluoro-3,4-dihydro-3,3-dimethylisoquinolin-1-yl)quinolone + TX, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3- (quinolyl)oxy]phenyl]propan-2-ol + TX, oxathiapiproline + TX, tert-butyl N-[6-[[[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate + TX, pyraziflumide + TX, inpirfluxam + TX, tolprocarb + TX, mefentrifluconazole + TX, ipfentrifluconazole + TX, 2-(difluoromethyl)-N-[(3R)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide + TX,N'-(2,5-dimethyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine + TX, N'-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethyl-phenyl]-N-ethyl-N-methyl-formamidine + TX, [2-[3-[2-[1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]thiazol-4-yl]-4,5-dihydroisoxazol-5-yl]-3-chloro-phenyl]methanesulfonate + TX, but-3-ynyl N-[6-[ [(Z)-[(1-Methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate + TX, methyl N-[[5-[4-(2,4-dimethylphenyl)triazol-2-yl]-2-methyl-phenyl]methyl]carbamate + TX, 3-chloro-6-methyl-5-phenyl-4-(2,4,6-trifluorophenyl)pyridazine + TX, pyridaclomethyl + TX, 3-(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide + T X, 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one + TX, 1-methyl-4-[3-methyl-2-[[2-methyl-4-(3,4,5-trimethylpyrazol-1-yl)phenoxy]methyl]phenyl]tetrazol-5-one + TX, aminopyrifen + TX, ametoctrazine + TX, amisulbrom + TX, penflufen + TX, (Z,2E)-5-[1-(4-chlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino- N,3-dimethyl-pent-3-enamide + TX, florylpicoxamide + TX, fenpicoxamide + TX, methallylpicoxamide + TX, tebufloquine + TX, ipflufenoquine + TX, quinofumelin + TX, isofetamide + TX, N-[2-[2,4-dichloro-phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide + TX, N-[2-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide + TX,Benzothiostrobin + TX, Fenamacryl + TX, 5-amino-1,3,4-thiadiazole-2-thiol zinc salt (2:1) + TX, Fluopyram + TX, Flufenoxadiazam + TX, Flutianil + TX, Fluopimomide + TX, Pyrapropoin + TX, Picarbtrazox + TX, 2-(difluoromethyl)-N-(3-ethyl-1,1-dimethyl-indan-4-yl)pyridine-3-carboxamide + TX, 2-(difluoromethyl)-N-((3R)-1,1,3-trimethyl 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, Methyltetraprole + TX, 2-(difluoromethyl)-N-((3R)-1,1,3-trimethylindan-4-yl)pyridine-3-carboxamide + TX, α-(1,1-dimethylethyl)-α-[4'-(trifluoromethyl)- Methoxy)[1,1'-biphenyl]-4-yl]-5-pyrimidinemethanol + TX, fluoxapiprolin + TX, enoxastrobin + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-sulfanyl-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX [[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4H-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4H-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile + TX, trinexapac + TX, cumoxystrobin + TX, chungchongmycin + TX, copper thiodiazole + TX, zinc thiazole + TX, amethotractin + TX, iprodione + TX, Seboxylamine + TX; N'-[5-bromo-2-methyl-6-[(1S)-1-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX; N'-[5-bromo-2-methyl-6-[(1R)-1-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX; N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX; N '-[5-chloro-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine + TX, N'-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-isopropyl-N-methyl-formamidine + TX (these compounds can be prepared from the method described in WO 2015 / 155075); N'-[5-bromo-2-methyl-6-(2-propoxypropoxy)-3-pyridyl]-N-ethyl- N-methyl-formamidine + TX (this compound can be prepared from the method described in IPCOM000249876D); N-isopropyl-N'-[5-methoxy-2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-phenyl-ethyl)phenyl]-N-methyl-formamidine + TX, N'-[4-(1-cyclopropyl-2,2,2-trifluoro-1-hydroxy-ethyl)-5-methoxy-2-methyl-phenyl]-N-isopropyl-N-methyl-formamidine + TX (these The compounds can be prepared from the methods described in WO 2018 / 228896; N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)oxetan-2-yl]phenyl]-N-methyl-formamidine + TX, N-ethyl-N'-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)tetrahydrofuran-2-yl]phenyl]-N-methyl-formamidine + TX (these compounds can be prepared from the methods described in WO 2019 / 110427);N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + TX, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide + TX, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carb...

Claims

1. A fungicidal composition comprising a mixture of components (A) and (B) as active ingredients, wherein component (A) is a compound represented by formula (I): 【Chemistry 1】 (In the formula, R 1 is hydrogen, C 1 ~C 4 Alkyl, C 2 ~C 4 Alkenyl, C 2 ~C 4 Alkynyl and C 3 ~C 6 cycloalkyl; R 2 is hydrogen, halogen, C 1 ~C 4 Alkyl, C 2 ~C 4 Alkenyl, C 2 ~C 4 Alkynyl, C 1 ~C 4 Haloalkyl, C 3 ~C 6 Cycloalkyl, C 1 ~C 4 Alkylcarbonyl, N—C 1 ~C 4 Alkoxy-C-C 1 ~C 4 Alkyl-carbonimidoyl, N-hydroxy-C-C 1 ~C 4 Alkyl-carbonimidoyl and C 1 ~C 4 alkoxycarbonyl; R 3 and R 4 are independently hydrogen, halogen and C 1 ~C 4 alkyl, R 5 and R 6 are independently hydrogen and C 1 ~C 4 alkyl, R 7 is hydrogen, C 1 ~C 4 Alkyl, C 1 ~C 4 Alkylcarbonyl, N—C 1 ~C 4 Alkoxy-C-C 1 ~C 4 Alkyl-carbonimidoyl, N-hydroxy-C-C 1 ~C 4 Alkyl-carbonimidoyl, C 1 ~C 4 Alkoxycarbonyl, N-methoxy-N-methyl-carbonyl, C 1 ~C 4 Alkylaminocarbonyl, di(C 1 ~C 4 alkylamino)carbonyl, phenyl, 5- or 6-membered heteroaryl and C 3 ~C 6 cycloalkyl, wherein said 5- or 6-membered heteroaryl contains 1, 2, 3, or 4 heteroatoms individually selected from N, O, and S, provided that not more than one is O or S; and wherein said phenyl, 5- or 6-membered heteroaryl, and C 3 ~C 6 -cycloalkyl is unsubstituted or substituted with halogen, cyano, C 1 ~C 4 Alkyl, C 1 ~C 4 Haloalkyl or C 1 ~C 4 substituted by 1, 2, or 3 substituents independently selected from alkoxy; B 1 is CR 10 or N, B 2 is CR 11 or N, R 8 , R 9 , R 10 and R 11 are independently hydrogen, halogen, C 1 ~C 4 Alkyl, C 1 ~C 4 Haloalkyl, C 1 ~C 4 Alkoxy, C 1 ~C 4 Haloalkoxy, C 2 ~C 4 Alkenyloxy, C 2 ~C 4 Alkynyloxy, C 1 ~C 4 Alkylsulfanyl, C 1 ~C 4 Alkylsulfinyl, C 1 ~C 4 Alkylsulfonyl, C 1 ~C 4 Alkoxy-C 1 ~C 4 Alkyl, C 1 ~C 4 Alkoxycarbonyl, C 1 ~C 4 Alkylcarbonyl, N—C 1 ~C 4 Alkoxy-C-C 1 ~C 4 Alkyl-carbonimidoyl, N-hydroxy-C-C 1 ~C 4 alkyl-carbonimidoyl, hydroxy, trifluoromethylsulfonyloxy, cyano, carboxy, phenyl, 5- or 6-membered heteroaryl and C 3 ~C 6 cycloalkyl, wherein said 5- or 6-membered heteroaryl contains 1, 2, 3, or 4 heteroatoms individually selected from N, O, and S, provided that not more than one is O or S; and wherein said phenyl, 5- or 6-membered heteroaryl, and C 3 ~C 6 -cycloalkyl is unsubstituted or substituted with halogen, cyano, C 1 ~C 4 Alkyl, C 1 ~C 4 Haloalkyl or C 1 ~C 4 substituted by 1, 2, or 3 substituents independently selected from alkoxy; A 1 , A 2 and A 3 is independently, CR 12 , N, N.R. 13 , O and S, with the proviso that A 1 , A 2 and A 3 is selected from N, O and S, and A 1 , A 2 and A 3 is O or S; R 12 is hydrogen, C 1 ~C 4 Alkyl, C 2 ~C 4 Alkenyl and C 2 ~C 4 alkynyl, R 13 is hydrogen, C 1 ~C 4 Alkyl, C 2 ~C 4 Alkenyl and C 2 ~C 4 alkynyl, and Z 1 is C 3 ~C 4 Alkyl, phenyl, 5- or 6-membered heteroaryl and C 3 ~C 6 cycloalkyl, wherein said 5- or 6-membered heteroaryl contains 1, 2, 3, or 4 heteroatoms individually selected from N, O, and S, provided that not more than one is O or S; and wherein said phenyl, 5- or 6-membered heteroaryl, and C 3 ~C 6 -cycloalkyl is unsubstituted or substituted with halogen, cyano, C 1 ~C 4 Alkyl, C 1 ~C 4 Haloalkyl, C 1 ~C 4 Alkoxy, C 1 ~C 4 Haloalkoxy, C 1 ~C 4 Alkylsulfanyl, C 1 ~C 4 Alkylsulfinyl, C 1 ~C 4 Alkylsulfonyl or C 2 ~C 4 substituted by 1, 2, or 3 substituents independently selected from alkynyl; is a compound of the formula: Component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumide, isoflucipram, impilfluxam, isofetamide, fluindapyr, cyclobutrifluram, fluoxastrobin, fenamidone, mandestrobin, picoxystrobin, pyraclostrobin, famoxadone, kresoxim-methyl, trifloxystrobin, azoxystrobin, methyltetraprole, Amisulbrom, cyazofamid, fenpicoxamide, florylpicoxamide, methallylpicoxamide, ametoctrazine, fluazinam, triphenyltin hydroxide, silthiofam, fenpropimorph, fenpropidin, spiroxamine, fenhexamid, imazalil, pyrisoxazole, bromuconazole, cyproconazole, difenoconazole, epoxiconazole, flutriafol, hexaconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, tebuconazole, tetraconazole fluoxetine, triticonazole, prothioconazole, fluoxythioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, kasugamycin, mancozeb, copper fungicides, sulfur, zinc thiazole, captan, folpet, chlorothalonil, dithianon, quinoxyfen, proquinazide, fludioxonil, iprodione, procymidone, thiabendazole, zoxamide, metrafenone, fluopicolide, propamocarb, oxathiapiproline, fluoxetine ... Xapiproline, acibenzolar-S-methyl, isotianil, phosphorous acid, cyflufenamid, tebufloquine, picarbutrazox, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro -quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(4 -propyltriazol-2-yl)phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2 -methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)-amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (Bacillus amyloliquefaciens amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria Molina extract-based plant extract (commercially available as BOTRISTOP®), and aureobasidin A, with the proviso that the compound of formula (I) is not: Table 1-1 Table 1-2 Table 1-3

2. Component (A) is a compound represented by formula (IA): 【Chemistry 2】 (In the formula, R 1 is methyl, R 2 is hydrogen, chlorine or methyl, R 3 is hydrogen, R 4 is hydrogen or methyl, R 5 and R 6 is hydrogen, R 7 is hydrogen, C 1 ~C 4 Alkyl or C 3 ~C 6 -cycloalkyl, R 8 is hydrogen, R 9 is hydrogen, bromine, chlorine, cyano, methyl or methoxy, B 1 is CH, B 2 is N or CR 11 and R 11 is hydrogen, A is A1, A4, A7, A9 or A10 【Transformation 3】 is selected from: 【Chemistry 4】 indicates a bond to a C(=O) group, and the arrow indicates a bond to a Z 1 indicates a bond to the group, and Z 1 is selected from phenyl or 6-membered heteroaryl, said heteroaryl containing one heteroatom selected from N, and said phenyl and said 6-membered heteroaryl being unsubstituted or substituted with 1 to 2 substituents selected from fluorine.

2. The fungicidal composition of claim 1, wherein the compound is

3. Component (A) is [5-(2,4-difluorophenyl)-1,3,4-oxadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.01), [3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.02), [4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-propyl-1,3,4-thiadiazol-2-yl)methanone (X.03), (5-cyclohexyl-1,3,4-thiadiazol-2-yl)-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.04), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.05), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[(4R)-4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.06), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.07), 1-[4-[2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-3,4-dihydro-1H-isoquinolin-4-yl]-2-methyl-pyrazol-3-yl]ethenone (X.08), Methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate (X.09), [5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.10), [4-(5-chloro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2,4-difluorophenyl)isoxazol-3-yl]methanone (X.11), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(5-fluoro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.12), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[3,3-dimethyl-4-(1-methylpyrazol-4-yl)-1,4-dihydroisoquinolin-2-yl]methanone (X.13), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.14), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[5-(1,3,5-trimethylpyrazol-4-yl)-6,8-dihydro-5H-1,7-naphthyridin-7-yl]methanone (X.15), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.16), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,2,4-oxadiazol-3-yl)methanone (X.17), (3-cyclohexylisoxazol-5-yl)-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.18), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone (X.19), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.20), [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.21), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.22), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(4-pyridyl)isoxazol-3-yl]methanone (X.23), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(3-pyridyl)isoxazol-3-yl]methanone (X.24), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2-pyridyl)isoxazol-3-yl]methanone (X.25), [5-(6-methoxy-3-pyridyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.26), [5-(2-methoxy-3-pyridyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.27), [5-(3,5-difluoro-2-pyridyl)-1,3,4-thiadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.28), or [5-(2,6-Difluoro-3-pyridyl)-1,3,4-thiadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.29) The fungicidal composition according to claim 1 or 2, wherein the compound is selected from the group consisting of:

4. Component (A) is [5-(2,4-difluorophenyl)-1,3,4-oxadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.01), [3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.02), [4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-propyl-1,3,4-thiadiazol-2-yl)methanone (X.03), (5-cyclohexyl-1,3,4-thiadiazol-2-yl)-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.04), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.05), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[(4R)-4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.06), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.07), 1-[4-[2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-3,4-dihydro-1H-isoquinolin-4-yl]-2-methyl-pyrazol-3-yl]ethenone (X.08), Methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate (X.09), [5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.10), [4-(5-chloro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2,4-difluorophenyl)isoxazol-3-yl]methanone (X.11), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(5-fluoro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.12), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[3,3-dimethyl-4-(1-methylpyrazol-4-yl)-1,4-dihydroisoquinolin-2-yl]methanone (X.13), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.14), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[5-(1,3,5-trimethylpyrazol-4-yl)-6,8-dihydro-5H-1,7-naphthyridin-7-yl]methanone (X.15), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.16), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,2,4-oxadiazol-3-yl)methanone (X.17), (3-cyclohexylisoxazol-5-yl)-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.18), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone (X.19), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.20), [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.21), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.22), [5-(3,5-difluoro-2-pyridyl)-1,3,4-thiadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.28), or [5-(2,6-Difluoro-3-pyridyl)-1,3,4-thiadiazol-2-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.29) The fungicidal composition according to any one of claims 1 to 3,

5. Component (A) is [3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.02), (5-cyclohexyl-1,3,4-thiadiazol-2-yl)-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.04), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-6-methoxy-1-methyl-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.05), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[(4R)-4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.06), [5-(2,4-difluorophenyl)-1,3,4-thiadiazol-2-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.07), 1-[4-[2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-3,4-dihydro-1H-isoquinolin-4-yl]-2-methyl-pyrazol-3-yl]ethenone (X.08), Methyl 2-[5-(2,4-difluorophenyl)isoxazole-3-carbonyl]-4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinoline-1-carboxylate (X.09), [4-(5-chloro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-[5-(2,4-difluorophenyl)isoxazol-3-yl]methanone (X.11), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(5-fluoro-1-methyl-pyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.12), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[3,3-dimethyl-4-(1-methylpyrazol-4-yl)-1,4-dihydroisoquinolin-2-yl]methanone (X.13), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-methyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.14), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1,5-dimethylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.16), [4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-(5-phenyl-1,3,4-oxadiazol-2-yl)methanone (X.19), [5-(2,4-difluorophenyl)isoxazol-3-yl]-[4-(1-methylpyrazol-4-yl)-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.20), [5-(3,5-difluoro-2-pyridyl)isoxazol-3-yl]-[rac-(1S,4S)-4-(1,5-dimethylpyrazol-4-yl)-1-methyl-3,4-dihydro-1H-isoquinolin-2-yl]methanone (X.21), or [5-(2,4-difluorophenyl)isoxazol-3-yl]-[(1S,4S)-1,4-dimethyl-4-(1-methylpyrazol-4-yl)-1,3-dihydroisoquinolin-2-yl]methanone (X.22) The fungicidal composition according to any one of claims 1 to 4, wherein

6. Component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumid, isoflucipram, inpirfluxam, fluindapyr, cyclobutrifluram, pyraclostrobin, trifloxystrobin, azoxystrobin, methyltetraprole, fenpicoxamide, florylpicoxamide, methallylpicoxamide, fluazinam, fenpropidin, fenhexamid, and cyproconazole. , difenoconazole, metconazole, penconazole, propiconazole, tebuconazole, tetraconazole, prothioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, mancozeb, copper compounds (different salts), sulfur, folpet, chlorothalonil, dithianon, proquinazide, fludioxonil, metrafenone, oxathiapiprolin, fluoxapiprolin, acibenzolar-S-methyl, phosphorous acid, cyflufena amide, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea fluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)- methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3- Carboxamide, methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(4-propyltriazol-2-yl)phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl) methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate (these compounds can be prepared from the method described in WO 2020 / 193387), 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-hexyl-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2, 2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethyl-cyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), Quillaja saponaria extract (commercially available as Quillaja saponaria extract), The bactericidal composition according to any one of claims 1 to 5, wherein the compound is selected from the group consisting of a plant extract based on an extract of Aureobasidin A (commercially available as BOTRISTOP®) and aureobasidin A.

7. Component (B) is selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, acibenzolar-S-methyl, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazol-4-yl] carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens 7. A fungicidal composition according to any one of claims 1 to 6, wherein the compound is selected from the group consisting of: Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), plant extracts based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®) and aureobasidin A.

8. The fungicidal composition according to any one of claims 1 to 7, wherein component (B) is a compound selected from the group consisting of pydiflumetofen, benzovindiflupyr, azoxystrobin, florylpicoxamide, difenoconazole, prothioconazole, mefentrifluconazole, cyprodinil, fludioxonil, and acibenzolar-S-methyl.

9. A fungicidal composition according to any one of claims 1 to 8, wherein the weight ratio of component (A) to component (B) is from 12:1 to 1:

25.

10. A fungicidal composition according to any one of claims 1 to 9, wherein the weight ratio of component (A) to component (B) is from 5:1 to 1:

15.

11. A fungicidal composition according to any one of claims 1 to 10, wherein the weight ratio of component (A) to component (B) is from 2:1 to 1:

5.

12. A further active ingredient (C) different from ingredient (B), which is pydiflumetofen, benzovindiflupyr, bixafen, fluxapyroxad, isopyrazam, penflufen, penthiopyrad, sedaxane, boscalid, fluopyram, thifluzamide, pyraziflumid, isoflucipram, inpirfluxam, isofetamide, fluindapyr, cyclobutrifluram, fluoxastrobin, fenamidone, mandestrobin, picoxystrobin, pyraclostrobin, famoxadone, kresoxim-methyl, triflurazole, thi ... Floxystrobin, azoxystrobin, methyltetraprole, amisulbrom, cyazofamid, fenpicoxamide, florylpicoxamide, methallylpicoxamide, ametoctrazine, fluazinam, triphenyltin hydroxide, silthiofam, fenpropimorph, fenpropidin, spiroxamine, fenhexamid, imazalil, pyrisoxazole, bromuconazole, cyproconazole, difenoconazole, epoxiconazole, flutriafol, hexaconazole, ipconazole, metconazole azole, myclobutanil, penconazole, propiconazole, tebuconazole, tetraconazole, triticonazole, prothioconazole, fluoxythioconazole, mefentrifluconazole, flufenoxadiazam, ipflufenoquin, quinofumelin, metalaxyl-M, cyprodinil, pyrimethanil, kasugamycin, mancozeb, copper fungicides, sulfur, zinc thiazole, captan, folpet, chlorothalonil, dithianon, quinoxyfen, proquinazide, fludioxonil, iprodione, prothiazol, thiazol-1, thiazol-2, thiazol-3, thiazol-4, thiazol-5, thiazol-6, thiazol-7, thiazol-8, thiazol-9, thiazol-10, thiazol-11, thiazol-12, thiazol-13, thiazol-14, thiazol-15, thiazol-16, thiazol-17, thiazol-18, thiazol-19, thiazol-20, thiazol-21, thiazol-22, thiazol-23, thiazol-24, thiazol-25, thiazol-26, thiazol-27, thiazol-28, thiazol-29 ... Cymidone, thiabendazole, zoxamide, metrafenone, fluopicolide, propamocarb, oxathiapiprolin, fluoxapiprolin, acibenzolar-S-methyl, isotianil, phosphorous acid, cyflufenamid, tebufloquine, picarbutrazox, tricyclazole, N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea, N-[(1R)-1-benzyl -3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide, 8-fluoro-N-[(1R)-1- [(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide, methyl (Z)-3-methoxy-2-[2-methyl-5-[4-(trifluoromethyl)triazol-2-yl]phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(4- propyltriazol-2-yl)phenoxy]prop-2-enoate, methyl (Z)-2-[5-(3-isopropylpyrazol-1-yl)-2-methyl-phenoxy]-3-methoxy-prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-(3-propylpyrazol-1-yl)phenoxy]prop-2-enoate, methyl (Z)-3-methoxy-2-[2-methyl-5-[3-(trifluoromethyl)pyrazol-1-yl]phenoxy]prop-2-enoate, methyl (Z)-2-(5-cyclohexyl-2- Methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, methyl (Z)-2-(5-cyclopentyl-2-methyl-phenoxy)-3-methoxy-prop-2-enoate, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-5-methyl-N-spiro[3.4]octan-3-yl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[cyano-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide )amino]-N-hexyl-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methoxyacetyl)-amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydropyran-4-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(oxetane-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(tetrahydrofuran-3-carbonyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[acetyl-(2,6-difluoro-4-pyridyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, 2-[(2,6-difluoro-4-pyridyl)-(2-methylpropanoyl)amino]-N-(2,2-dimethylcyclobutyl)-5-methyl-thiazole-4-carboxamide, TAEGRO® (i.e., Bacillus amyloliquefaciens amyloliquefaciens strain FZB24), Melaleuca alternifolia oil (extract of the tea tree plant Melaleuca alternifolia (commercially available as Timorex Gold®, a broad-spectrum botanical biofungicide)), Reynoutria sachalinensis extract (commercially available as REGALIA®), plant extract based on Quillaja saponaria Molina extract (commercially available as BOTRISTOP®) and aureobasidin A.

13. A fungicidal composition according to any one of claims 1 to 12, further comprising an agriculturally acceptable carrier and, optionally, a surfactant and / or formulation adjuvant.

14. A method for controlling or preventing phytopathogenic diseases, in particular phytopathogenic fungi, of useful plants or their propagation material, which method comprises applying to said useful plants, their habitat or their propagation material a fungicidal composition according to any one of claims 1 to 12.

15. 15. The method of claim 14, wherein components (A) and (B) of the composition are applied sequentially.

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