Treatment Devices

Abstract

A treatment device is provided that mixes a first liquid and a second liquid in a tube without using gas and discharges the mixed liquid together with a treatment liquid. [Solution] A treatment device comprising a tube having a central lumen, a first outer lumen, a second outer lumen, a partition wall portion, and a coil, wherein the coil transforms from a first form that isolates the radially inner space of the coil from the radially outer space to a second form that connects the radially inner space to the radially outer space, one of the central lumen, the first outer lumen, and the second outer lumen is a treatment liquid lumen for flowing a treatment liquid, another is a first liquid lumen for flowing a first liquid, and the remaining is a second liquid lumen for flowing a second liquid that forms a gel by mixing with the first liquid, and when the treatment liquid lumen is the central lumen, both the first liquid lumen and the second liquid lumen are blocked at the tip.

Description

[Technical Field]

[0001] The present disclosure relates to therapeutic devices. [Background technology]

[0002] BACKGROUND ART A therapeutic device is known that mixes and discharges a first liquid, a second liquid that forms a gel when mixed with the first liquid, and a gas (see, for example, Patent Document 1). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2010-75412 Summary of the Invention [Problem to be solved by the invention]

[0004] An object of the present disclosure is to provide a treatment device that mixes a first liquid and a second liquid in a tube without using gas and discharges the mixed liquid together with a treatment liquid. [Means for solving the problem]

[0005] One aspect of the present disclosure is as follows.

[0006] [1] A therapeutic device comprising: a tube having a central lumen, a first outer lumen, a second outer lumen, a partition wall separating the first outer lumen from the second outer lumen, and a coil provided at a distal end of the tube; The coil is formed by a spirally wound wire and deforms from a first form that isolates a radially inner space of the coil from a radially outer space to a second form that connects the radially inner space to the radially outer space, the first outer lumen is isolated from the central lumen by the coil in the first configuration and communicates with the central lumen upon transformation of the coil to the second configuration; the second outer lumen is isolated from the central lumen by the coil in the first configuration and communicates with the central lumen upon transformation of the coil to the second configuration; one of the central lumen, the first outer peripheral lumen, and the second outer peripheral lumen is a treatment liquid lumen through which a treatment liquid flows and which has a treatment liquid outlet at the distal end; the other of the central lumen, the first outer peripheral lumen, and the second outer peripheral lumen is a first liquid lumen through which a first liquid flows; the remaining one of the central lumen, the first outer peripheral lumen, and the second outer peripheral lumen is a second liquid lumen for flowing a second liquid that forms a gel by mixing with the first liquid; When the therapeutic fluid lumen is the central lumen, both the first fluid lumen and the second fluid lumen are blocked at the distal end, A treatment device, wherein when the treatment liquid lumen is the first outer peripheral lumen or the second outer peripheral lumen, one or both of the first liquid lumen and the second liquid lumen are blocked at the tip portion.

[0007] [2] a therapeutic fluid syringe for supplying the therapeutic fluid to the therapeutic fluid lumen, the therapeutic fluid syringe having a therapeutic fluid outer cylinder and a therapeutic fluid plunger; a first liquid syringe that supplies the first liquid to the first liquid lumen, the first liquid syringe having a first liquid outer cylinder and a first liquid plunger; a second liquid syringe for supplying the second liquid to the second liquid lumen, the second liquid syringe having a second liquid outer cylinder and a second liquid plunger; the treatment liquid outer cylinder, the first liquid outer cylinder, and the second liquid outer cylinder are integrally formed, The treatment device according to [1], wherein the treatment liquid plunger, the first liquid plunger, and the second liquid plunger are integrally provided.

[0008] [3] the first liquid plunger has a first liquid compression spring that is compressed in the axial direction of the first liquid outer cylinder, The treatment device according to [2], wherein the second liquid plunger has a second liquid compression spring that is compressed in the axial direction of the second liquid outer cylinder.

[0009] [4] The treatment device described in any one of [1] to [3], wherein the coil is deformed from the first shape to the second shape by hydraulic pressure acting on whichever of the central lumen, the first outer lumen, and the second outer lumen is blocked at the tip.

[0010] [5] a sheath that accommodates the tube radially inside, The treatment device described in any one of [1] to [4], wherein the coil has a tendency to bend radially into the second shape, and the coil is transformed from the first shape to the second shape when the tip of the tube is ejected from the tip of the sheath.

[0011] [6] The treatment device according to any one of [1] to [5], wherein the first liquid and the second liquid are mixed in at least one of the central lumen, the first outer peripheral lumen, and the second outer peripheral lumen. [Effects of the Invention]

[0012] According to the present disclosure, it is possible to provide a treatment device that mixes a first liquid and a second liquid in a tube without using gas and discharges the mixed liquid together with a treatment liquid. [Brief explanation of the drawings]

[0013] [Figure 1] 1 is a partial cross-sectional side view showing a state in which a treatment device according to a first embodiment of the present disclosure is in use. [Figure 2A] 2 is a cross-sectional view showing a state in which the coil of the treatment device shown in FIG. 1 is in a first form. FIG. [Figure 2B] 2B is a cross-sectional view taken along the line AA in FIG. 2A. [Figure 3] 2B is a cross-sectional view showing a state when the coil is deformed from the state shown in FIG. 2A to a second form. FIG. [Figure 4] FIG. 2B is a cross-sectional view of FIG. 2A. [Figure 5] FIG. 10 is a side view showing a portion of a treatment device according to a second embodiment of the present disclosure. [Figure 6] FIG. 10 is a cross-sectional view showing a portion of a treatment device according to a third embodiment of the present disclosure. [Figure 7] FIG. 7 is a projection view as seen in the direction of arrow B in FIG. 6. [Figure 8] FIG. 10 is a cross-sectional view showing a portion of a treatment device according to a fourth embodiment of the present disclosure. [Figure 9] 9 is a projection view as seen in the direction of arrow C in FIG. 8. [Figure 10] FIG. 10 is a cross-sectional view showing a portion of a treatment device according to a fifth embodiment of the present disclosure. [Figure 11] 11 is a projection view seen in the direction of arrow D in FIG. 10. [Figure 12] FIG. 13 is a cross-sectional view showing a state in which a coil of a treatment device according to a sixth embodiment of the present disclosure is in a first form. [Figure 13] 13 is a cross-sectional view showing a state in which the coil is deformed from the state shown in FIG. 12 to a second form. DETAILED DESCRIPTION OF THE INVENTION

[0014] Hereinafter, embodiments of the present disclosure will be described in detail with reference to the drawings.

[0015] 1 to 4, a treatment device 1 according to a first embodiment of the present disclosure includes a tube 2 having a central lumen 2a, a first outer circumferential lumen 2b, a second outer circumferential lumen 2c, a partition wall 2d separating the first outer circumferential lumen 2b from the second outer circumferential lumen 2c, and a coil 2e provided at the distal end of the tube 2. The coil 2e is formed of a spirally wound wire 2e1 and transforms from a first configuration (see FIG. 2A) that separates a radially inner space 3 of the coil 2e from a radially outer space 4 to a second configuration (see FIG. 3) that connects the radially inner space 3 to the radially outer space 4. The first outer circumferential lumen 2b is isolated from the central lumen 2a by the coil 2e in the first configuration, and is connected to the central lumen 2a by the transformation of the coil 2e into the second configuration. The second outer lumen 2c is isolated from the central lumen 2a by the coil 2e in the first configuration, and communicates with the central lumen 2a when the coil 2e is transformed into the second configuration.

[0016] One of the central lumen 2a, the first outer peripheral lumen 2b, and the second outer peripheral lumen 2c is a treatment liquid lumen 5 (shaded portion in FIGS. 1 to 4) through which a treatment liquid flows and which has a treatment liquid outlet 5a at its distal end. The other of the central lumen 2a, the first outer peripheral lumen 2b, and the second outer peripheral lumen 2c is a first liquid lumen 6 through which a first liquid flows. The remaining one of the central lumen 2a, the first outer peripheral lumen 2b, and the second outer peripheral lumen 2c is a second liquid lumen 7 through which a second liquid flows that forms a gel when mixed with the first liquid. In this way, all of the central lumen 2a, the first outer peripheral lumen 2b, and the second outer peripheral lumen 2c flow liquids. The liquids in the central lumen 2a, the first outer peripheral lumen 2b, and the second outer peripheral lumen 2c may contain gas.

[0017] In this embodiment, the therapeutic fluid lumen 5 is the central lumen 2a, and both the first fluid lumen 6 and the second fluid lumen 7 are closed at the distal end.

[0018] In this embodiment, the direction along the central axis O of the tube 2 is called the axial direction, the side along the axial direction from the treatment liquid syringe 8, the first liquid syringe 9, and the second liquid syringe 10 toward the treatment liquid outlet 5a is called the tip side, and the opposite side is called the base side, the direction perpendicular to the central axis O is called the radial direction, and the direction circumferentially around the central axis O is called the circumferential direction.

[0019] The treatment liquid is a liquid containing a therapeutic substance. The treatment substance is not particularly limited and may be, for example, a drug or cells. The drug is not particularly limited and may be, for example, a low-molecular-weight compound, a protein, a plasmid, a gene, a growth factor, a chemoattractant, a synthetic polypeptide, an extracellular vesicle, or an exosome. The cell is not particularly limited and may be, for example, a somatic cell or a stem cell. The cell may be, for example, a cardiomyocyte derived from somatic stem cells (adult stem cells), mesenchymal stem cells, or iPS cells (induced pluripotent stem cells). The somatic stem cells are preferably skeletal myoblasts (myoblast cells). The first and second liquids are not particularly limited as long as they form a gel when mixed, and may be, for example, fibrinogen and thrombin. By supplying the treatment liquid together with the gel to the treatment site 11 (treatment target site) in a living body, the treatment liquid is more likely to remain in the treatment site 11, thereby enhancing the therapeutic effect.

[0020] The tube 2 includes an inner tube 2f having a distal end connected to the proximal end of the coil 2e, and an outer tube 2g surrounding the inner tube 2f and the coil 2e and having a distal end connected to the distal end of the coil 2e. The partition portion 2d includes a first partition 2d1 extending from the distal end of the outer tube 2g to the proximal end and connecting the inner circumferential surface of the outer tube 2g with the outer circumferential surfaces of the inner tube 2f and the coil 2e, and a second partition 2d2 extending from the distal end of the outer tube 2g to the proximal end at a circumferentially different position from the first partition 2d1 and connecting the inner circumferential surface of the outer tube 2g with the outer circumferential surfaces of the inner tube 2f and the coil 2e. The inner tube 2f is the only tube that supplies a liquid (therapeutic liquid) to the axial distal side toward the radially inner space 3 of the coil 2e, and is provided coaxially with the coil 2e. The first partition 2d1 and the second partition 2d2 may be configured to be in close contact with the outer peripheral surface of the coil 2e without being adhered to it, or may be configured to be adhered to the outer peripheral surface of the coil 2e in the first form and to be unadhered when the coil 2e changes to the second form.

[0021] The distal end of the outer tube 2g has a cylindrical protrusion 2g1 that protrudes distally beyond the distal end of the coil 2e, and the central lumen 2a is formed by the protrusion 2g1, the coil 2e, and the inner circumferential surface of the inner tube 2f. The outer tube 2g may be configured without the protrusion 2g1. The first outer circumferential lumen 2b and the second outer circumferential lumen 2c are formed between the outer tube 2g and the coil 2e and inner tube 2f, and are separated from each other by a first partition 2d1 and a second partition 2d2.

[0022] In the illustrated example, the coil 2e is composed of a single wire 2e1. However, this is not limited to this, and the coil 2e may be a multi-filament wound type composed of two or more wires 2e1. The wire 2e1 forming the coil 2e has a circular spiral shape when viewed in the axial direction. However, this is not limited to this, and the coil 2e may have an elliptical spiral shape, for example. The cross-sectional shape of the wire 2e1 is circular, but is not limited to this, and may be a polygonal shape such as a rectangle. By making the cross-sectional shape of the wire 2e1 rectangular, the outer peripheral surface of the coil 2e may be configured to smoothly extend in the axial direction in the first configuration. In this case, when the coil 2e transforms from the first configuration to the second configuration, interference of the outer peripheral surface of the coil 2e with the partition wall 2d in close contact with the outer peripheral surface of the coil 2e is reduced, thereby facilitating the transformation of the coil 2e to the second configuration. In this embodiment, the inner tube 2f and the outer tube 2g are cylindrical, but this is not limited to this, and the coil 2e may have an elliptical cylindrical shape, for example. In this embodiment, the first partition 2d1 and the second partition 2d2 are provided so that the flow path cross-sectional areas of the first outer peripheral lumen 2b and the second outer peripheral lumen 2c are equal, but this is not limiting.

[0023] The treatment device 1 includes a treatment liquid syringe 8 for supplying a treatment liquid to the treatment liquid lumen 5, the treatment liquid syringe 8 having a treatment liquid outer cylinder 8a and a treatment liquid plunger 8b; a first liquid syringe 9 for supplying a first liquid to the first liquid lumen 6, the first liquid syringe 9 having a first liquid outer cylinder 9a and a first liquid plunger 9b; and a second liquid syringe 10 for supplying a second liquid to the second liquid lumen 7, the second liquid syringe 10 having a second liquid outer cylinder 10a and a second liquid plunger 10b. The treatment liquid outer cylinder 8a, the first liquid outer cylinder 9a, and the second liquid outer cylinder 10a are integrally formed. The treatment liquid plunger 8b, the first liquid plunger 9b, and the second liquid plunger 10b are integrally formed.

[0024] The proximal end of the inner tube 2f is connected to the distal end of the therapeutic liquid sheath 8a. The tube 2 has a first branch tube 2h, the distal end of which is connected to a portion that forms the proximal end of the first outer peripheral lumen 2b, which is made up of the proximal end of the outer tube 2g, the proximal end of the partition 2d, and a portion of the inner tube 2f. The structure for connecting the distal end of the first branch tube 2h to this portion is not particularly limited, and for example, the distal end of the first branch tube 2h may be integrated with this portion by thermal fusion. The proximal end of the first branch tube 2h is connected to the distal end of the first liquid sheath 9a. The tube 2 has a second branch tube 2i, the distal end of which is connected to a portion that forms the proximal end of the second outer peripheral lumen 2c, which is made up of the proximal end of the outer tube 2g, the proximal end of the partition 2d, and a portion of the inner tube 2f. The structure for connecting the tip end of the second branch tube 2i to this portion is not particularly limited, and for example, the tip end of the second branch tube 2i may be integrated with this portion by heat fusion. The base end of the second branch tube 2i is connected to the tip end of the second liquid outer cylinder 10a.

[0025] In this embodiment, the coil 2e is deformed from the first shape to the second shape by fluid pressure acting on the first outer circumferential lumen 2b and the second outer circumferential lumen 2c. The fluid pressure is applied by a first fluid syringe 9 and a second fluid syringe 10.

[0026] According to this embodiment, the distal end of the tube 2 can be delivered to a treatment site 11 (between the pericardium 11a and the heart 11b after pericardial fluid has been removed as necessary) in a living body such as a human, with the first and second liquids separated by the septum and the first type of coil 2e. By simultaneously operating the integrated plungers of the treatment liquid syringe 8, the first liquid syringe 9, and the second liquid syringe 10, the therapeutic substance contained in the treatment liquid can be discharged from the treatment liquid outlet 5a without applying excessive pressure, and fluid pressure can be applied to the first outer lumens 2b and the second outer lumens 2c, which are closed at the distal end, to extend the distal end of the tube 2 in the axial direction. This operation extends the coil 2e in the axial direction, and the first outer lumens 2b and the second outer lumens 2c communicate with the central lumen 2a through the gaps between the adjacent wires 2e1. The first and second liquids then flow from the first and second outer lumens 2b and 2c into the central lumen 2a, where they are mixed and then mixed with the therapeutic liquid and simultaneously discharged from the therapeutic liquid outlet 5a. At this time, a good mixing effect can be achieved by the stirring caused by the inflow through the coil 2e. Furthermore, the discharge operation is easy, as it only requires operating the integrated plunger.

[0027] The treatment device 1 of this embodiment is configured to simultaneously supply liquid from the integrated outer cylinder to the treatment liquid lumen 5, the first outer peripheral lumen 2b, and the second outer peripheral lumen 2c by operating the integrated plungers, but is not limited thereto. For example, as in a second embodiment shown in FIG. 5 , the first liquid plunger 9b may have a first liquid compression spring 9c compressed in the axial direction of the first liquid outer cylinder 9a, and the second liquid plunger 10b may have a second liquid compression spring 10c compressed in the axial direction of the second liquid outer cylinder 10a. According to the second embodiment, an appropriate amount of treatment liquid is first ejected depending on the flexibility of the first liquid compression spring 9c and the second liquid compression spring 10c, and then a treatment liquid containing a mixture of the first and second liquids can be ejected.

[0028] In the treatment device 1 of this embodiment, the supply of liquid to each lumen is performed by a syringe device in which three outer cylinders and three plungers are integrated, but this is not limiting, and the supply of liquid to each lumen may be performed by a separate syringe. The supply of liquid to each lumen may also be performed by a device other than a syringe device.

[0029] The treatment device 1 of this embodiment has a configuration in which the treatment liquid lumen 5 is the central lumen 2a, and both the first liquid lumen 6 and the second liquid lumen 7 are closed at the distal end, but is not limited to this. For example, as in the third to fifth embodiments, the treatment liquid lumen 5 may be the first outer circumferential lumen 2b or the second outer circumferential lumen 2c, and one or both of the first liquid lumen 6 and the second liquid lumen 7 may be closed at the distal end.

[0030] 6-7, the therapeutic liquid lumen 5 is the first outer circumferential lumen 2b, the central lumen 2a, which is one of the first liquid lumen 6 and the second liquid lumen 7, is closed at its distal end, and the second outer circumferential lumen 2c, which is the other of the first liquid lumen 6 and the second liquid lumen 7, has an outlet 2c1 at its distal end. The tube 2 has an occluding portion 2j that is continuous with the distal end of the outer tube 2g and closes the distal end of the central lumen 2a, and the distal end of the outer tube 2g forms the therapeutic liquid outlet 5a and the outlet 2c1 of the second outer circumferential lumen 2c. The therapeutic liquid outlet 5a and the outlet 2c1 of the second outer circumferential lumen 2c each extend in the axial direction. According to this embodiment, by operating the plunger, hydraulic pressure is applied to the central lumen 2a, which is closed at its distal end, and the distal end of the tube 2 is extended in the axial direction. This causes the coil 2e to extend in the axial direction, and the first outer circumferential lumen 2b and the second outer circumferential lumen 2c communicate with the central lumen 2a through the gaps between adjacent wires 2e1. One of the first and second liquids flows from the central lumen 2a into the first and second outer circumferential lumen 2b and 2c and is mixed. The first or second liquid that flows into the first outer circumferential lumen 2b mixes with the treatment liquid and is discharged from the treatment liquid outlet 5a. The second or second liquid that flows into the second outer circumferential lumen 2c mixes with the other of the first and second liquids and is discharged from the outlet 2c1. While the number of treatment liquid outlets 5a and outlets 5a is not particularly limited, the number of each is three in this embodiment.

[0031] In the fourth embodiment shown in FIGS. 8 and 9, the therapeutic liquid lumen 5 is the first outer peripheral lumen 2b, and both the first liquid lumen 6 and the second liquid lumen 7, that is, the central lumen 2a and the second outer peripheral lumen 2c, are closed at their distal ends. The tube 2 has a closing portion 2j that is continuous with the distal end of the outer tube 2g and closes the distal end of the central lumen 2a, and the distal end of the outer tube 2g forms a therapeutic liquid outlet 5a. The therapeutic liquid outlet 5a extends in the axial direction. According to this embodiment, by operating the plunger, hydraulic pressure is applied to the central lumen 2a and the second outer peripheral lumen 2c, which are closed at their distal ends, thereby extending the distal end of the tube 2 in the axial direction. As a result, the coil 2e extends in the axial direction, and the first outer peripheral lumen 2b and the second outer peripheral lumen 2c communicate with the central lumen 2a through the gaps between adjacent wires 2e1. Then, one of the first and second liquids flows from the second outer peripheral lumen 2c into the central lumen 2a, and the first and second liquids flow from the central lumen 2a into the first outer peripheral lumen 2b, where they are mixed and then mixed with the treatment liquid and discharged from the treatment liquid outlet 5a. The number of treatment liquid outlets 5a is not particularly limited, but in this embodiment there are three.

[0032] In the fifth embodiment shown in FIGS. 10 and 11, the therapeutic fluid lumen 5 is the first outer peripheral lumen 2b, the second outer peripheral lumen 2c, which is one of the first fluid lumen 6 and the second fluid lumen 7, is closed at its distal end, and the central lumen 2a, which is the other of the first fluid lumen 6 and the second fluid lumen 7, has an outlet 2a1 at its distal end. The distal end of the outer tube 2g forms the therapeutic fluid outlet 5a and the outlet 2a1 of the central lumen 2a. The therapeutic fluid outlet 5a and the outlet 2a1 of the central lumen 2a each extend in the axial direction. According to this embodiment, by operating the plunger, fluid pressure is applied to the second outer peripheral lumen 2c, which is closed at its distal end, causing the distal end of the tube 2 to expand in the axial direction. This causes the coil 2e to expand in the axial direction, and the second outer peripheral lumen 2c communicates with the central lumen 2a through the gaps between adjacent wires 2e1. Then, one of the first and second liquids flows from the second outer peripheral lumen 2c into the central lumen 2a, where it is mixed with the other of the first and second liquids and discharged from the outlet 2a1. Also, the therapeutic liquid flowing through the first outer peripheral lumen 2b is discharged from the therapeutic liquid outlet 5a.

[0033] In each of the above-described embodiments, the coil 2e is configured to deform from the first shape to the second shape by hydraulic pressure acting on one of the central lumen 2a, the first outer circumferential lumen 2b, and the second outer circumferential lumen 2c that is blocked at the distal end, thereby mixing the first and second liquids in at least one of the central lumen 2a, the first outer circumferential lumen 2b, and the second outer circumferential lumen 2c. However, this is not limiting. For example, as in a sixth embodiment shown in FIGS. 12 and 13 , the treatment device 1 may have a sheath 12 that houses the tube 2 radially inside, and the coil 2e may have a bending tendency that causes it to bend radially into the second shape. The distal end of the tube 2 is ejected from the distal end of the sheath 12, thereby deforming the coil 2e from the first shape to the second shape, thereby mixing the first and second liquids in at least one of the central lumen 2a, the first outer circumferential lumen 2b, and the second outer circumferential lumen 2c. The configuration of the sixth embodiment may be combined with the configurations of the other embodiments.

[0034] Although the embodiments of the present disclosure have been described above, the present disclosure is not limited to the above-described embodiments, and the above-described embodiments can be modified in various ways without departing from the gist of the present disclosure. [Explanation of symbols]

[0035] 1. Treatment Device 2 tubes 2a central lumen 2a1 Discharge port 2b First peripheral lumen 2c Second peripheral lumen 2c1 Discharge port 2d bulkhead 2d1 1st bulkhead 2d2 2nd bulkhead 2e coil 2e1 wire rod 2f inner tube 2g outer tube 2g1 Protrusion 2h First branch tube 2i Second branch tube 2j Occlusion 3 Radial inner space 4 Radial outer space 5 Treatment fluid lumen 5a Treatment liquid outlet 6 First fluid lumen 7 Second liquid lumen 8 Syringe for treatment fluid 8a Treatment liquid outer tube 8b Treatment liquid pusher 9. Syringe for first liquid 9a First liquid outer cylinder 9b Pusher for 1st liquid 9c Compression spring for first liquid 10 Second liquid syringe 10a Second liquid outer cylinder 10b 2nd liquid pusher 10c Compression spring for second liquid 11 Treatment department 11a Pericardium 11b Heart 12 Sheath O center axis

Claims

1. A therapeutic device comprising: a tube having a central lumen, a first outer lumen, a second outer lumen, a partition wall separating the first outer lumen from the second outer lumen, and a coil provided at a distal end of the tube; The coil is formed by a spirally wound wire and deforms from a first form that isolates a radially inner space of the coil from a radially outer space to a second form that connects the radially inner space to the radially outer space, the first outer lumen is isolated from the central lumen by the coil in the first configuration and communicates with the central lumen upon transformation of the coil to the second configuration; the second outer lumen is isolated from the central lumen by the coil in the first configuration and communicates with the central lumen upon transformation of the coil to the second configuration; one of the central lumen, the first outer peripheral lumen, and the second outer peripheral lumen is a treatment liquid lumen through which a treatment liquid flows and which has a treatment liquid outlet at the distal end; the other of the central lumen, the first outer peripheral lumen, and the second outer peripheral lumen is a first liquid lumen through which a first liquid flows; the remaining one of the central lumen, the first outer peripheral lumen, and the second outer peripheral lumen is a second liquid lumen through which a second liquid that forms a gel by mixing with the first liquid flows; When the therapeutic fluid lumen is the central lumen, both the first fluid lumen and the second fluid lumen are blocked at the distal end, A treatment device, wherein when the treatment fluid lumen is the first outer peripheral lumen or the second outer peripheral lumen, one or both of the first fluid lumen and the second fluid lumen are blocked at the tip portion.

2. a therapeutic fluid syringe for supplying the therapeutic fluid to the therapeutic fluid lumen, the therapeutic fluid syringe having a therapeutic fluid outer cylinder and a therapeutic fluid plunger; a first liquid syringe for supplying the first liquid to the first liquid lumen, the first liquid syringe having a first liquid outer cylinder and a first liquid plunger; a second liquid syringe for supplying the second liquid to the second liquid lumen, the second liquid syringe having a second liquid outer cylinder and a second liquid plunger; the treatment liquid outer cylinder, the first liquid outer cylinder, and the second liquid outer cylinder are integrally provided, The treatment device according to claim 1 , wherein the treatment fluid plunger, the first fluid plunger, and the second fluid plunger are integrally provided.

3. the first liquid plunger has a first liquid compression spring that is compressed in the axial direction of the first liquid outer cylinder, The treatment device according to claim 2 , wherein the second liquid plunger has a second liquid compression spring that is compressed in the axial direction of the second liquid outer cylinder.

4. The treatment device of claim 1 , wherein the coil is deformed from the first shape to the second shape by hydraulic pressure acting on one of the central lumen, the first outer lumen, and the second outer lumen that is occluded at the distal end.

5. a sheath that accommodates the tube radially inside, The treatment device according to claim 1, wherein the coil has a bending tendency such that it curves radially into the second shape, and the coil is transformed from the first shape to the second shape when the distal end of the tube is ejected from the distal end of the sheath.

6. The treatment device of claim 1 , wherein the first liquid and the second liquid are mixed in at least one of the central lumen, the first peripheral lumen, and the second peripheral lumen.

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