Cosmetics or topical skin preparations containing tocopherol nicotinate

Abstract

The object of the present invention is to provide a cosmetic or topical skin preparation that improves upon the undesirable feel of water-soluble whitening agents, such as stickiness and a squeaky sensation. [Solution] A water-soluble whitening agent and tocopherol nicotinate are combined and incorporated into a cosmetic or topical skin preparation. According to the present invention, by combining a water-soluble whitening agent and tocopherol nicotinate in a cosmetic or topical skin preparation, undesirable sensations such as stickiness and squeaky feeling of the water-soluble whitening agent can be improved.

Description

Technical Field

[0001] The present invention relates to a cosmetic or a topical skin preparation containing nicotinic acid tocopherol.

Background Art

[0002] In recent years, various whitening agents have been developed and formulated in cosmetics and topical skin preparations for the purpose of preventing spots and freckles and maintaining fair and transparent skin. As such whitening agents, tranexamic acid or its derivatives, ascorbic acid or its derivatives, hydroquinone or its derivatives, nicotinic acid or its derivatives, salicylic acid or its derivatives, etc. are generally used, but all of these are water-soluble components. Such water-soluble whitening agents exhibit excellent whitening effects, but on the other hand, they have problems in terms of usability such as a strong sticky feeling and a harsh feeling, and it is required to improve the usability of such water-soluble whitening agents (for example, Patent Documents 1 to 3).

[0003] On the other hand, since nicotinic acid tocopherol has a vasodilating action, it has conventionally been used in various cosmetics or topical skin preparations for the purpose of promoting blood circulation in the skin and scalp. However, the effects achieved by combining it with a water-soluble whitening agent are not known.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Patent Document 2

Patent Document 3

Summary of the Invention

Problems to be Solved by the Invention

[0005] The object of the present invention is to provide a cosmetic or topical skin preparation that improves the feel of a water-soluble whitening agent. [Means for solving the problem]

[0006] The inventors of this invention conducted extensive research to solve the above problems and, as a result, discovered that the aforementioned problems could be solved by combining a water-soluble whitening agent with tocopherol nicotinate, thus completing the present invention. [Effects of the Invention]

[0007] According to the present invention, by combining a water-soluble whitening agent with tocopherol nicotinate, it is possible to improve the undesirable feeling of stickiness and stiffness associated with water-soluble whitening agents. [Modes for carrying out the invention]

[0008] The present invention relates to a cosmetic or topical skin preparation containing the following components (A) and (B). (A) One or more water-soluble whitening agents selected from tranexamic acid or its derivatives, ascorbic acid or its derivatives, hydroquinone or its derivatives, nicotinic acid or its derivatives, and salicylic acid or its derivatives. (B) Tocopherol nicotinate

[0009] The water-soluble whitening agent component (A) used in the present invention is one or more selected from tranexamic acid or its derivatives, ascorbic acid or its derivatives, hydroquinone or its derivatives, nicotinic acid or its derivatives, and salicylic acid or its derivatives.

[0010] Specific examples of tranexamic acid or its derivatives include tranexamic acid; ester derivatives such as tranexamic acid cetyl ester; and amide derivatives such as tranexamic acid methylamide. These may be used individually or in combination of two or more. They may also be in salt form. Among these, tranexamic acid is preferred.

[0011] Specific examples of ascorbic acid or its derivatives include ascorbic acid; 2-O-ethyl ascorbic acid, 3-O-ethyl ascorbic acid, 2,3-O-diethyl ascorbic acid, 2-O-glyceryl ascorbic acid, 3-O-glyceryl ascorbic acid, 2,3-O-glyceryl ascorbic acid, butyl 2-glyceryl ascorbic acid, butyl 3-glyceryl ascorbic acid, caprylyl 2-glyceryl ascorbic acid, caprylyl 3-glyceryl ascorbic acid, ethylhexyl 2-glyceryl ascorbic acid, ethylhexyl 3-glyceryl ascorbic acid, lauryl 2 2,3-O-diethyl ascorbic acid, 2-O-glyceryl ascorbic acid, 3-O-glyceryl as Examples include ether derivatives such as lyl-3-glyceryl ascorbate, myristyl-2-glyceryl ascorbate, myristyl-3-glyceryl ascorbate, cetyl-2-glyceryl ascorbate, and cetyl-3-glyceryl ascorbate; phosphate ester derivatives such as ascorbyl phosphate, isostearyl ascorbyl phosphate, ascorbyl palmitate phosphate, and ascorbyl isopalmitate phosphate; sugar derivatives such as ascorbyl glucoside and palmitoyl ascorbyl glucoside; sulfate ester derivatives such as ascorbyl sulfate; and acyl derivatives such as ascorbyl palmitate and ascorbyl stearate. These may be used individually or in combination of two or more. They may also be in salt form. Among these, 3-O-ethyl ascorbic acid, ascorbyl phosphate, and ascorbyl glucoside are preferred.

[0012] Specific examples of hydroquinone or its derivatives include hydroquinone; and glycosides of hydroquinone with sugars selected from xylose, galactose, glucose, mannose, fructose, maltose, trehalose, lactose, and sucrose. These may be used alone or in combination of two or more. They may also be in salt form. Among these, arbutin, a glycoside of hydroquinone and glucose, is a preferred example.

[0013] Specific examples of nicotinic acid or its derivatives include nicotinic acid; amide derivatives such as nicotinamide; and ester derivatives such as methyl nicotinate, ethyl nicotinate, and benzyl nicotinate. These may be used individually or in combination of two or more. They may also be in salt form. Among these, nicotinamide is preferred.

[0014] Specific examples of salicylic acid or its derivatives include salicylic acid, methoxysalicylic acid, methyl salicylate, capryloyl salicylic acid, and betaine salicylic acid. These may be used individually or in combination of two or more. They may also be in salt form. Of these, methoxysalicylic acid is preferred.

[0015] There are no particular restrictions on the content of component (A) in the cosmetic or topical skin preparation of the present invention, but from the viewpoint of better exhibiting the effects of the present invention, it is 0.1 to 10% by mass, preferably 0.2 to 8% by mass, more preferably 0.3 to 6% by mass, and most preferably 0.5 to 4% by mass.

[0016] The component (B) used in this invention, tocopherol nicotinate, is an ester compound of nicotinic acid and tocopherol, and is also known as vitamin E nicotinate, vitamin E nicotinate ester, or tocopherol nicotinate ester.

[0017] There are no particular restrictions on the content of component (B) in the cosmetic or topical skin preparation of the present invention, but from the viewpoint of better exhibiting the effects of the present invention, it is 0.01 to 2% by mass, preferably 0.025 to 1.5% by mass, and more preferably 0.05 to 1.2% by mass.

[0018] In the cosmetic or topical skin preparation of the present invention, component (B) is used for the purpose of improving the feel of component (A). From the viewpoint of further exhibiting this effect, the mass ratio of component (B) to component (A), (B) / (A), is preferably 0.01 to 0.5, more preferably 0.015 to 0.3, and more preferably 0.02 to 0.2.

[0019] Component (A) used in the present invention is water-soluble, while component (B) is oil-soluble. Therefore, in the cosmetic or topical skin preparation of the present invention, it is preferable to incorporate component (A) into the aqueous phase and component (B) into the aqueous phase in an emulsified or solubilized state by an emulsifier. In the present invention, the effects of the present invention can be better exhibited by incorporating components (A) and (B) in this form. Since tocopherol nicotinate is an oil-soluble component, it can be encapsulated in the lipid bilayer membrane of liposomes formed by phospholipids, etc., so component (B) can also be incorporated into the aqueous phase in this form. However, since liposomes have higher membrane strength compared to emulsion particles, the effects of the present invention by tocopherol nicotinate become less likely to be exhibited, which is therefore undesirable.

[0020] As an emulsifier used to incorporate component (B) of the present invention into the aqueous phase, anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymeric surfactants, etc., can be used. Of these, nonionic surfactants are preferred from the viewpoint of better exhibiting the effects of the present invention.

[0021] More specifically, examples of the nonionic surfactant include glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, polyoxyethylene glycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene sterol ether, polyoxyethylene hydrogenated castor oil, alkyl glucoside, mannosyl erythritol lipid, and the like. Among these, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene sterol ether, and polyoxyethylene hydrogenated castor oil are more preferable.

[0022] In the cosmetic or external skin preparation of the present invention, water and additive components usually blended in cosmetics, such as oily bases, humectants / slipperiness improvers, surfactants, polymers / thickeners / gelling agents, antioxidants, reducing agents, oxidizing agents, anti-oxidants, whitening agents, vitamins and their derivatives, extracts of plants / animals / microorganisms, ultraviolet absorbers, antibacterial / antiseptic agents, chelating agents, pH adjusters / acids / alkalis, solvents / propellants, antipruritics, keratolytic / dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory agents, hair growth agents / blood circulation promoters / stimulants, hormones, anti-wrinkle / anti-aging agents, irritation relievers, cooling sensation agents, warming sensation agents, powders, pigments / colorants / dyes / pigments, fragrances, etc. may be contained as long as the effects of the present invention are not impaired.

[0023] As oily bases, higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachidodecanol, behenyl alcohol, jojoba alcohol, chymyl alcohol, cerachidodecanol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimergol, etc.; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, Undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acids, hydrogenated dimer acids, and other higher fatty acids, as well as metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, and sodium salts thereof, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin Hydrocarbons such as α-olefin oligomers, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; waxes such as candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, and olive oil. Vegetable oils such as oils, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, peach kernel oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, etc.; animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil, etc.; animal waxes such as whale wax, lanolin, orange roughy oil, etc.Lanolins such as liquid lanolin, reduced lanolin, adsorbed and purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate alcohol, and (cetyl lanolyl) acetate; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and sphingomyelin; Phospholipids such as gophospholipids, phosphatidic acid, cyclic lysophosphatidic acid or its salts, and lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, and partially hydrogenated egg yolk phospholipid; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, Cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), N-lauroyl sarcosinate isopropyl, etc. Acyl sarcosinate alkyl Sterol esters such as cholesteryl 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid, phytosteryl macadamia nut oil fatty acid, phytosteryl sunflower seed oil fatty acid, phytosteryl isostearate, cholesteryl soft lanolin fatty acid, cholesteryl hard lanolin fatty acid, long-chain branched fatty acid cholesteryl, long-chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid-cholesterol complexes and phospholipid-phytosterol complexes;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palimitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolate, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, Monoalcoholic carboxylic acid esters such as ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolinate, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate, etc.; oxyacid esters such as cetyl lactate, hydrogenated castor oil monoisostearate, γ-erucalactone, diisostearyl malate;Glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic / capric triglyceride, caprylic / capric / myristic / stearic triglyceride, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl eicosanedioate behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, dicaprylic trioctanoate Neopentyl glycol dioctanoate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearate / sebacate), pentaerythrityl triethylhexanoate, dipentaerythrityl (hydroxystearate / stearate / rosinate), diglyceryl diisostearate, polyglyceryl tetraisostearate Polyglyceryl-10 nonaisostearate, polyglyceryl-8 deca(erucic acid / isostearate / ricinoleic acid), diglyceryl oligoester (hexyldecanoic acid / sebacic acid), glycol distearate (ethylene glycol distearate), polyhydric alcohol fatty acid esters such as 3-methyl-1,5-pentanediol dieopentanoate and 2,4-diethyl-1,5-pentanediol dieopentanoate; alkyl ethers such as dicaprylyl ether; diisopropyl dimer dilinoleate, dima Dimer acids or dimer ol derivatives such as diisostearyl dilinoleate, di(isostearyl / phytosteryl) dimer dilinoleate, (phytosteryl / behenyl) dimer dilinoleate, (phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate, dimer dilinoleyl diisostearate, hydrogenated rosin condensate of dimer dilinoleate, hydrogenated castor oil of dimer dilinoleate, and hydroxyalkyl dimer dilinoleyl ether;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA), etc.; Silicones such as dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethylsilicone, phenyldimethylsilicone, (aminoethylaminopropylmethylsilicone / dimethylsilicone) copolymer, dimethiconol, dimethiconol cross polymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyldimethylsilicone and amodimethicone, cation-modified silicone, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, amidoalkyl-modified silicone, aminoglycol-modified silicone, aminophenyl-modified silicone, silicone-oxyalkylene copolymers such as polysiloxane·oxyalkylene copolymer; Fluorine-based oil agents such as perfluorodecane, perfluorooctane, perfluoropolyether, etc. are preferably mentioned.;

[0024] As moisturizers and texture enhancers, polyols and their polymers such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, erythrita, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol / propylene glycol copolymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, tetradecanedioic acid polyglyceryl-10, and cyclohexanedicarboxylic acid bisethoxydiglycol; and sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, and maltitol. Glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, glucosyltrehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrins, and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextrin Sugars and their derivatives such as orchids, glycogen, ethyl glucoside, glucosylethyl methacrylate polymers or copolymers; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, kerato sulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, naturally derived polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and their salts; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salts;Amino acids and their salts, such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine, collagen, fish collagen, atelocollagen, gelatin, elastin, collagen-degraded peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degraded peptides, keratin-degraded peptides, hydrolyzed keratin, conchiolin-degraded peptides, hydrolyzed conchiolin, silk protein-degraded peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soy protein-degraded peptides, wheat protein-degraded peptides , hydrolyzed wheat protein, casein hydrolyzed peptides, acylated peptides and other protein peptides and their derivatives; palmitoyl oligopeptides, palmitoyl pentapeptides, palmitoyl tetrapeptides and other acylated peptides; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesamin glycosides, glutathione, albumin, whey; choline chloride, phosphorylcholine; placental extract, aerlastin, collagen, allo Preferred ingredients include animal and plant extracts such as E. japonica extract, witch hazel water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Rosa rugosa extract, yarrow extract, eucalyptus extract, and sweet clover extract; natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudoceramides, sphingosine, sphingomyelin, sphingoglycolipids, ceramides, and glycoceramide-containing extracts.

[0025] Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, and polymeric surfactants. There are no particular restrictions on the HLB of surfactants; those with a low HLB of around 1 to a high HLB of around 20 can be used, and combinations of low and high HLB surfactants are also preferred. Examples of preferred surfactants include, among anionic surfactants, fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate esters such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methylalanine, sodium lauroyl sarcosinate, triethanolamine lauroyl sarcosinate, and sodium lauroyl glutamate methylalanine; and sodium cocoyl glutamate, triethanolamine cocoyl glutamate, and sodium lauroyl glutamate. Acyl amino acid salts such as sodium myristoyl glutamate, sodium stearoyl glutamate, palmitoyl aspartate ditriethanolamine, cocoyl alanine triethanolamine, sodium dilauroyl glutamate lysine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinate esters such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty acid amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as hydrogenated coconut oil fatty acid glycerin sulfate sodium; alkylbenzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and sodium dioctyl sulfosuccinate;Alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate, triethanolamine tetradecylbenzenesulfonate; alkylnaphthalene sulfonates; alkane sulfonates; α-sulfo fatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooleth phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphates; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or their salts; carboxylic acid-modified silicones, phosphate-modified silicones, sulfuric acid-modified silicones, etc. Lycorn-based anionic surfactants, etc.; nonionic surfactants include various polyoxyethylene alkyl ethers with different polyoxyethylene addition numbers, such as laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), beheneth (polyoxyethylene behenyl ether), isosteareth (polyoxyethylene isostearyl ether), octyldodeceth (polyoxyethylene octyldodecyl ether), etc.; polyoxyethylene alkylphenyl ethers Castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyloglutamic acid monoisostearate diester, polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin;Polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl. ) Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, coconut oil fatty acid glyceryl, monocottonseed oil fatty acid glycerin, monoerucate glycerin, sesquioleate glycerin, α,α'-oleate pyroglutamate glycerin, monostearate glycerin malic acid and other glycerin fatty acid partial esters; polyglyceryl-2, 3, 4, 5, 6, 8 stearate , same 10, polyglyceryl-6 distearate, same 10, polyglyceryl-2 tristearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 isostearate, same 3, same 4, same 5, same 6, same 8, same 10, polyglyceryl-2 diisostearate (diglyceryl diisostearate), same 3, same 10, polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, same 3, Polyglycerin fatty acid esters such as Polyglyceryl-6 dioleate, Polyglyceryl-2 trioleate, Polyglyceryl-10 decaoleate; Ethylene glycol monofatty acid esters such as Ethylene glycol monostearate; Propylene glycol monofatty acid esters such as Propylene glycol monostearate; Pentaerythritol partial fatty acid ester; Sorbitol partial fatty acid ester; Maltitol partial fatty acid ester; Maltitol ether;Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, sorbitan penta-2-ethylhexyl diglycerol sorbitan, sorbitan tetra-2-ethylhexyl diglycerol sorbitan; sucrose fatty acid esters such as sucrose laurate, sucrose myristate, sucrose palmitate, sucrose dilaurate, sucrose dimyristate, sucrose dipalmitate. Partial esters of sugar derivatives such as methyl glucoside fatty acid esters and undecylenate trehalose; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; glycolipids such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene glycol Polyoxyethylene glycerin fatty acid esters such as serine monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate, and other polyoxyethylene monooleates; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chymyl alcohol, cerakyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers;Polyoxyethylene alkylamines; tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins, surfactin, rhamnolipids, and sophorolipids; polyoxyethylene fatty acid amides; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid Fatty acid alkanolamides such as palmitate monoethanolamide (paltamide MEA), palmitate diethanolamide (paltamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA); alkyldimethylamine oxides such as lauramine oxide, cocamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, and polyglycerin-modified silicones. Silicone-based nonionic surfactants such as silicones and sugar-modified silicones; cationic surfactants include alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amide amines and their salts such as stearamidopropyldimethylamine and stearamidoethyldiethylamine; alkyl etheramines and their salts or quaternary salts such as stearoxypropyldimethylamine; fatty acid amide-type quaternary ammonium salts such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium and ethyl sulfate lanolin fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and their salts or quaternary salts; alkylamine salts; fatty acid amide guanidium salts; alkyl etheramine mononium salts; alkyltrial chloroglycol ammonium salts; benzalkonium salts;Benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmolyphonium salts; polyamine fatty acid derivatives; silicone-based cationic surfactants such as aminopropyl dimethicone and amodimethicone (amino-modified silicones), cationic-modified silicones, cationic and polyether-modified silicones, amino-modified and polyether-modified silicones; amphoteric surfactants such as N-alkyl-N,N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N,N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; Preferred surfactants include: alkyl sulfobetaines such as alkyldimethyl taurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin; phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxylated lecithin; silicone-based amphoteric surfactants, etc.; polymeric surfactants include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymer; and various silicone-based surfactants.

[0026] Examples of polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed gum, carrageenan, galactan, gum arabic, tara gum, tamarind, fercerelan, karaya gum, okra gum, tragacanth gum, pectin, pectic acid and its salts, alginic acid and its salts, mannan; starches from rice, corn, potato, wheat, etc.; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin, chitosa Agar, cassia seed extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, carboxylated cellulose nanofiber, carboxymethylated cellulose nanofiber, phosphate-esterified cellulose nanofiber, sulfonated cellulose nanofiber, sodium cellulose sulfate, dialkyldimethylammonium sulfur Cellulose and its derivatives such as cellulose acid, crystalline cellulose, and cellulose powder; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, and methyl starch; starch derivatives such as hydroxypropyltrimonium chloride starch and aluminum corn starch octenyl succinate; alginate derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA), vinylpyridone-vinyl alcohol copolymer, and polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, and polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate ester copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer and (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, and (alkyl acrylate / diacetone acrylamide) copolymer AMP;Polyvinyl acetate partially saponified, maleic acid copolymer; vinylpyrrolidone dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylamide; polyacrylic acid ester copolymers such as ethyl polyacrylate, carboxyvinyl polymer, salts such as polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate copolymer; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid / diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-39, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylamide copolymer, polyquaternium-47, etc. Copolymers of lylic acid, methyl acrylate, methacrylamidopropyltrimethylammonium chloride, choline methacrylate ester polymer; cationized oligosaccharides, cationized dextran, guar hydroxypropyltrimonium chloride, and other cationized polysaccharides; polyethyleneimine; cationic polymers; polymers of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and butyl methacrylate copolymers, etc.; polymer emulsions such as acrylic resin emulsions, ethyl polyacrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate;Preferred materials include anhydrous silicic acid, fuzzy silica (ultrafine particle anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soaps, dialkyl metal phosphates, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters.

[0027] Preferred antioxidants include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine ​​hydrochloride. Preferred reducing agents include thioglycolic acid, cysteine, and cysteamine. Preferred oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate. Preferred antioxidants include vitamin A compounds such as retinol, retinyl acetate, retinyl palmitate, and hydrogenated retinol; vitamin E compounds such as tocopherol, tocopherol acetate, and tocotrienol; carotenoids such as carotene, lycopene, astaxanthin, and lutein; polyphenols such as phlorotannin, curcumin, anthocyanins, proanthocyanidins, catechins, ellagic acid, quercetin, and apple polyphenols; and coenzyme Q10, lipoic acid, lactoferrin, sesamin, hesperidin, protoanthocyanidins, lignans, chlorogenic acid, rutin, fullerene, and platinum nanocolloids.

[0028] Preferred whitening agents include ascorbic acid fatty acid esters such as ascorbic acid dipalmitate and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as cetyl ascorbic acid; ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; and plant extracts such as kojic acid, ellagic acid, ferulic acid and their derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, willow extract, and saxifrage extract.

[0029] Preferred vitamins and their derivatives include vitamin A compounds such as retinol, retinyl acetate, and retinyl palmitate; B vitamins such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acid compounds, and choline compounds; vitamin D; vitamin E compounds such as α, β, γ, and δ-tocopherols; other vitamins such as pantothenic acid and biotin; vitamin derivatives such as tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate esters; tocotrienols; and various other vitamin derivatives.

[0030] Plant, animal, and microbial extracts include iris extract, angelica extract, Thujopsis dolabrata extract, asparagus extract, avocado extract, Hydrangea macrophylla extract, almond extract, marshmallow extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, fig extract, fennel extract, turmeric extract, oolong tea extract, bearberry extract, rosehip extract, Echinacea leaf extract, Enmeisou extract, scutellaria extract, phellodendron bark extract, Coptis japonica extract, barley extract, ginseng extract, St. John's wort extract, and Lamium album. Grass extract, Ononis extract, Nasturtium extract, Orange extract, Dried seawater, Seaweed extract, Persimmon leaf extract, Arctium extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria lobata extract, Chamomile extract, Oil-soluble chamomile extract, Carrot extract, Artemisia capillaris extract, Oat extract, Chloranthus extract, Licorice extract, Oil-soluble licorice extract, Kiwi extract, Kelp extract, Wood ear mushroom extract, Cinchona extract, Cucumber extract, Paulownia leaf extract, Guanosine, Guava extract, Sophora flavescens extract, Gardenia extract, Sasa veitchii extract, Sophora flavescens extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar extract, chlorella extract, mulberry extract, gentian extract, Geranium thunbergii extract, black tea extract, yeast extract, Magnolia bark extract, coffee extract, burdock extract, rice extract, rice fermentation extract, rice bran fermentation extract, rice germ oil, comfrey extract, collagen, lingonberry extract, Asarum sieboldii extract, Bupleurum chinense extract, umbilical cord extract, saffron extract, sage extract, soapwort extract, bamboo extract, hawthorn extract, sunflower extract Kiss, Japanese pepper extract, shiitake mushroom extract, rehmannia extract, lithospermum extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, ginger extract, calamus root extract, birch extract, white fungus extract, horsetail extract, stevia extract, stevia ferment, iris extract, ivy extract, hawthorn extract, elderberry extract, yarrow extract, peppermint extract, sage extract, mallow extract, chuanxiong extract, swertia japonica extract, mulberry bark extract, rhubarb extract,Soybean extract, jujube extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, cogongrass extract, citrus peel extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, Ophiopogon extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, Isodon japonicus extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur extract, Poria cocos extract, butcher's broom extract, grape extract, grape seed extract Preferred extracts include those of kiss, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, cypress extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, lemon balm extract, seaweed extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, reishi mushroom extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and Sanguisorba officinalis extract.

[0031] Examples of UV absorbers include benzoic acid-based UV absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerol ester, N,N-dipropoxypara-aminobenzoate ethyl ester, N,N-diethoxypara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate ethyl ester, N,N-dimethylpara-aminobenzoate butyl ester, and N,N-dimethylpara-aminobenzoate ethyl ester; anthranilic acid-based UV absorbers such as homomenthyl-N-acetylanthranilate; amyl salicylate, menthyl salicylate, and homomenthyl Salicylic acid-based UV absorbers such as salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanolphenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxy cinnamate, isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy cinnamate, 2-ethylhexyl p-methoxy cinnamate Cinnamic acid-based UV absorbers such as (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, ferulic acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4' Benzophenone-based UV absorbers such as -dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone;3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole); dibenzarazine; dianisioylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyltri Preferred materials include azon; urocanic acid derivatives such as urocanic acid and ethyl urocanic acid; hydantoin derivatives such as 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, and 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate; phenylbenzimidazol sulfonic acid, terephthalylidene dicamphor sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives; and oryzanol and its derivatives.

[0032] As antibacterial and preservative agents, parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); lanolin fatty acids and their salts; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, salts Benzethonium oxide, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenols, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol and other phenols; phenylethyl alcohol, photosensitizers, antimicrobial zeolites, and silver ions are preferred. However, when used as an antimicrobial agent or preservative for preservation purposes, from the viewpoint of safety for cosmetics or topical skin preparations, phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; and alkylglyceryl ethers such as 2-ethylhexylglyceryl ether are more preferred.

[0033] Preferred chelating agents include edetates (ethylenediaminetetraacetates) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetates such as HEDTA3Na; pentetates (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and their sodium salts; sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, succinic acid, and tartaric acid.

[0034] Preferred pH adjusters, acids, and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

[0035] Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and di Preferred propellants include glycol ethers such as propylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation chlorofluorocarbons; LPG, dimethyl ether, and carbon dioxide.

[0036] Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance-P inhibitors. Examples of exfoliating and dissolving agents include sulfur, resorcinol, selenium sulfide, pyridoxine, and glycolic acid. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol. Examples of astringent agents include citric acid, tartaric acid, lactic acid, potassium aluminum sulfate, tannic acid, and caffeine. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and adenosine triphosphate disodium.

[0037] Preferred anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, azelaic acid and its derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract. Preferred hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, Capsicum tincture, Ginger tincture, Ginger extract, and Cantharis tincture; capsaicin, nonylic acid valenylamide, gingerol, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, trazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, derivatives such as vitamin E and tocopherol acetate, derivatives such as γ-oryzanol, inositol hexanicotinate, and nicotinic alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmamanol and its glycosides, and minoxidil. Preferred hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.

[0038] Preferred anti-wrinkle and anti-aging agents include vitamin A compounds such as retinol, retinyl acetate, retinyl palmitate, and hydrogenated retinol; glutathione, cysteine, crocetin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanidins, pantothenic acid, panthenol, soy saponins, revelastol, isoflavones, coenzyme Q10, chondroitin sulfate, acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptides, conchiolin hydrolysates, adenosine 5'-monophosphate, phosphatidylinositol, and sodium trifluoride isopropyl oxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetate.

[0039] Preferred irritation-reducing agents include mannosylerythritol lipid, diethylene glycol dimer dilinoleate oligomer ester, diisostearyl malate, N-acyl-L-glutamic acid, trehalose monofatty acid ester, fatty acid amidoamine oxide, alkyldimethylamine oxide, phenylethyl glucoside, lauryl glucoside, ferulic acid glucoside, salicin, cedrol, polyethylene glycol, and polypropylene glycol. Preferred cooling agents include menthol, camphor, menthyl lactate, monomentyl succinate, menthyl acetate, borneol, cineole, thymol, peppermint oil, and their derivatives. Preferred warming agents include vanillin and its derivatives, vanillyl nonanoate, gingerol, gingerol, capsicum tincture, capsicum extract, capsaicin, watercress extract, sansho pepper extract, ginger extract, and canthari extract.

[0040] Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium dioxide, fine and ultrafine titanium dioxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fuzzy silica (ultrafine anhydrous silicic acid), and titanium mica. Preferred materials include inorganic powders of various sizes and shapes such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorphlogopite, fine particle composite powders, gold, aluminum, and inorganic powders that have been hydrophobized or hydrophilized by treating them with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silanes or titanium coupling agents; organic powders of various sizes and shapes such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminated powder, polyethylene terephthalate-aluminum-epoxy laminated powder, urethane powder, silicone powder, Teflon® powder, and other organic powders and surface-treated powders, as well as organic-inorganic composite powders.Preferred inorganic salts include sodium chloride-containing salts such as table salt, regular salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; and sodium phosphates such as 1Na, 2Na, and 3Na phosphates, potassium phosphates, calcium phosphates, and magnesium phosphates.

[0041] As pigments, colorants, dyes, and dyes, these include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402 Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 3, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223 , Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 40 No. 4, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange 20 Statutory dyes such as No. 5, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Yellow No. 5, etc.; Acid Other acid dyes such as Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; nitro dyes such as HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, and Basic Blue 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and lower titanium oxide;Inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium dioxide-coated mica, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; anthraquinones such as astaxanthin and alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin Natural pigments and dyes such as tin, crocin, chlorophyll, curcumin, naphthoquinones such as cochineal and shikonin, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidative dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-,m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and their salts; auto-oxidative dyes such as indoline; and dihydroxyacetone are preferred.

[0042] The fragrance ingredients include acetylcedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, iso-esuper, isobutylquinoline, iris oil, ylone, indole, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragol, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carbone, camphor, canone, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styraryl acetate, cedyl acetate, terepinel acetate, and pt-butylcyclohexyl acetate. Lu, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanol, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-Nonadienol, Nonalactone, Patchouli Alcohol, Vanilla Absolute, Vanillin, Basil Oil, Patchouli Oil, Hydroxycitronellal, α-Pinene, Piperitone, Phenethyl Alcohol, Phenylacetaldehyde, Petitgrain Oil, Hexyl Cinnamaldehyde, cis-3-Hexenol, Peruvian Balsam, Vetiver Oil, Vetiverol, Peppermint Oil, Pepper Oil, Heliotropin, Bergamot Oil, Benzyl Benzoate Preferred examples include synthetic and natural fragrances such as benzoate, borneol, myrrhizinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, liral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances.

[0043] In addition to tap water and purified water, preferred types of water include hard water, soft water, natural water, deep-sea water, electrolyzed alkaline ionized water, electrolyzed acidic ionized water, ionized water, and clustered water.

[0044] In addition to these, it is possible to include known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., in known combinations, formulation ratios, and amounts, such as ingredients listed in the Cosmetic Raw Material Standards, Cosmetic Ingredient Formulation Standards, Japan Cosmetic Industry Association Ingredient Labeling Name List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Raw Material Standards, Japanese Pharmacopoeia, Pharmaceutical Additives Standards, Food Additives Compendium, etc., as well as ingredients listed in Japanese and foreign patent gazettes and patent publications (including published and republished gazettes) belonging to the International Patent Classification IPC A61K7 and A61K8 classifications.

[0045] Examples of cosmetic compositions of the present invention include hair cosmetics, skin cosmetics, makeup cosmetics, fragrance cosmetics, and body cosmetics. Cosmetics of the present invention can be manufactured according to conventional methods.

[0046] To further describe the types of cosmetics of the present invention, preferred hair cosmetics include shampoos such as oil shampoos, cream shampoos, conditioning shampoos, anti-dandruff shampoos, hair color shampoos, and rinse-integrated shampoos; hair care products such as rinses, conditioners, treatments, hair packs, leave-on treatments, hair mists, and hair oils; hair styling products such as hair foams, hair mousses, hair sprays, hair waxes, hair gels, hair creams, water greases, setting lotions, pomades, and hair sticks; hair dyes such as color lotions, hair color treatments, hair manicures, and oxidative hair dyes; and hair tonics, hair liquids, hair blowers, split end coats, permanent wave agents, straight perm agents, hair bleaches, hair color pre-treatments, hair color after-treatments, perm pre-treatments, perm after-treatments, and hair growth agents.

[0047] Skin cosmetics include toners such as softening toners, astringent toners, cleansing toners, multi-layer toners, and liposome toners; lotions such as emollient lotions, moisturizing lotions, milky lotions, nourishing lotions, nourishing milks, skin moisturizers, moisturizing emulsions, massage lotions, exfoliating smoothers, elbow lotions, hand lotions, and body lotions; emollient creams, nourishing creams, nourishing creams, vanishing creams, moisturizing creams, night creams, massage creams, cleansing creams, makeup creams, base creams, pre-makeup creams, sunscreen creams, suntan creams, hair removal creams, deodorant creams, shaving creams, and exfoliating creams. Preferred products include skincare cosmetics such as creams including softening creams, moisturizing gels, whitening gels, all-in-one gels, moisturizing essences, whitening essences, moisturizing serums, whitening serums, and other beauty serums; sunscreen cosmetics such as sun protectors, sun protectors, UV care milks, and sunscreens; packs and masks such as peel-off packs, powder packs, washing packs, oil packs, and cleansing masks; cleansing cosmetics such as cleansing foams, cleansing creams, cleansing milks, cleansing lotions, cleansing gels, and cleansing oils; and facial cleansers such as paste facial cleansing foams, gel facial cleansing foams, foaming facial cleansing foams, facial cleansing powders, cosmetic soaps, clear soaps, medicated soaps, liquid soaps, and shaving soaps.

[0048] Preferred makeup products include lipstick, lip gloss, foundation, blush, face powder, concealer, eyeliner, mascara, eyeshadow, eyebrow pencil, eyebrow products, nail polish, nail polish remover, and nail treatment.

[0049] Preferred fragranced cosmetics include perfumes, fragrances, parfums, eau de parfums, eau de toilettes, eau de colognes, solid perfumes, fragrance powders, fragranced soaps, body lotions, and bath oils.

[0050] Preferred body cosmetics include body washes such as body shampoos, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks, deodorizing cosmetics, bleaching agents, hair removal agents, bath additives, and insect repellents such as insect repellent sprays.

[0051] The present invention can be used as a topical skin preparation in the form of an ointment, lotion, cream or gel, patch, liniment, or liquid application. It can also be used as an oral cosmetic such as toothpaste or mouthwash.

[0052] Preferred dosage forms for the cosmetic or topical skin preparation of the present invention include emulsified cosmetics such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, and O / W / O type, as well as oily cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick cosmetics, volatile oil-type cosmetics, powder cosmetics, jelly-type cosmetics, gel-type cosmetics, paste-type cosmetics, emulsified polymer-type cosmetics, sheet-type cosmetics, mist-type cosmetics, and spray-type cosmetics.

[0053] The present invention will be further described in detail by the following examples, but the present invention is not limited thereto.

[0054] <Evaluation of user experience> Lotions containing components (A) and (B) of the present invention were prepared according to the compositions shown in Tables 1 and 2 (Examples 1-3). For comparison, a lotion without component (B) of the present invention was prepared (Comparative Example 1). In addition, a lotion without components (A) and (B) of the present invention was prepared as a control. The feel of the obtained lotions when applied to the skin was evaluated using the method described below, and the results are shown together in Tables 1 and 2. User experience evaluation method Based on the sensory evaluations of five panelists, the following evaluation criteria were used. The results are shown as the average score of the five panelists. Evaluation Criteria 5 points: Quite good compared to control 4 points: Better than control 3 points: Equivalent to control 2 points: Poor compared to control 1 point: Quite bad compared to control

[0055] [Table 1]

[0056] [Table 2]

[0057] The results in Tables 1 and 2 show that undesirable sensations such as stickiness and squeaky feeling caused by ingredient (A) are improved when used in combination with ingredient (B). Furthermore, it was found that the skin's ability to absorb the product improved when ingredients (A) and (B) were used together compared to the control group.

[0058] Example 9: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Ethanol 5.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C, mix, and cool. Add part A and stir until uniform.

[0059] Example 10: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.0 Part B Phenoxyethanol 0.3 Purified water, in an amount that totals 100. C part Polyglyceryl-10 laurate 0.5 1,3-Butylene glycol 4.0 Nicotinate tocopherol 0.15 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C, mix, and cool. Add part A and stir until uniform.

[0060] Example 11: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.5 Part B Glyceryl caprylate 0.5 Purified water, in an amount that totals 100. C part Polyglyceryl-10 isostearate 0.6 1,3-Butylene glycol 3.0 Nicotinate tocopherol 0.2 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C, mix, and cool. Add part A and stir until uniform.

[0061] Example 12: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.5 Part B Glyceryl caprylate 0.5 Purified water, in an amount that totals 100. C part Polyglyceryl-10 laurate 0.6 1,3-Butylene glycol 3.0 Propanediol 2.0 Propylene glycol 1.0 Dipropylene glycol 0.5 Pentylene glycol 1.0 Diglycerin 0.8 Glycerin 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C, mix, and cool. Add part A and stir until uniform.

[0062] Example 13: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Glyceryl caprylate 0.5 Purified water, in an amount that totals 100. C part Polyglyceryl-10 laurate 0.6 Neosolue-AquaS (Nippon Fine Chemical) 1.0 Neosolue-Aqulio (Nippon Seika) 1.0 Propanediol 2.0 Diglycerin 0.8 Glycerin 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C, mix, and cool. Add part A and stir until uniform.

[0063] Example 14: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.5 Part B Ethylhexylglycerin 0.5 Purified water, in an amount that totals 100. C part Polyglyceryl-10 oleate 0.6 Phytocompo HS (Nippon Fine Chemical) 0.5 PrimeLipid ALPA (Nippon Fine Chemical) 0.1 Neosolue-Aqulio (Nippon Seika) 0.5 Propanediol 2.0 Glycerin 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C, mix, and cool. Add part A and stir until uniform.

[0064] Example 15: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.5 Part B Phenoxyethanol 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Sodium hyaluronate (molecular weight 1.5 million) 0.05 Xanthan gum 0.2 C part Polyglyceryl-10 oleate 0.6 Inulin-SC (Nippon Fine Chemical) 0.5 Propanediol 2.0 Glycerin 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C separately to approximately 80°C, mix, and cool. Add part A and stir until uniform (viscosity 1000 mPa·s).

[0065] Example 16: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Phenoxyethanol 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Tamarind seed gum 0.2 Sodium alginate 0.1 Phytic acid 0.1 C part LP70H (Nippon Seika) 0.2 Phytopresome (Nippon Seika) 0.3 Propylene glycol 5.0 Pentylene glycol 2.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C separately to approximately 80°C, mix, and cool. Add part A and stir until uniform (viscosity 500 mPa·s, pH 6.5).

[0066] Example 17: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.5 Part B Phenoxyethanol 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Locust bean gum 0.2 Xanthan gum 0.2 C part LP70H (Nippon Seika) 0.2 Phytopresome Cera-236 (Nippon Seika) 0.3 Propylene glycol 5.0 1,3-Butylene glycol 5.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, mix with a homomixer (5000 rpm), and then cool. Add part A and mix until uniform (viscosity 1600 mPa·s).

[0067] Example 18: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.5 Part B Artemisia capillaris extract 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Locust bean gum 0.2 Xanthan gum 0.2 C part Phytopresome Plus (Nippon Fine Chemical) 2.0 Propylene glycol 5.0 1,3-Butylene glycol 5.0 Nicotinate tocopherol 0.2 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, mix with a homomixer (8000 rpm), and then cool. Add part A and mix until uniform (viscosity 1600 mPa·s).

[0068] Example 19: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.5 Part B Artemisia capillaris extract 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Locust bean gum 0.1 Xanthan gum 0.3 C part Phytocompo-PP (Nippon Fine Chemical) 1.0 LP70H (Nippon Seika) 0.3 Glycerin 5.0 1,3-Butylene glycol 5.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then pass through a high-pressure emulsifier (70 MPa) twice and cool. Add part A and stir until uniform (viscosity 2000 mPa·s).

[0069] Example 20: Brightening lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Dipotassium glycyrrhizinate 0.2 Part B Clove extract 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Gellan gum 0.2 Xanthan gum 0.4 Glucosyltrehalose 1.0 Lactobacillus / Pear Juice Ferment Filtrate 0.2 C part PrimeLipid ALPA (Nippon Fine Chemical) 0.8 Phytopresome Cera-236 (Nippon Seika) 0.1 Glycerin 2.0 Dipropylene glycol 8.0 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then pass through a high-pressure emulsifier (100 MPa) twice and cool. Add part A and stir until uniform (viscosity 2000 mPa·s, pH 5.5).

[0070] Example 21: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Clove extract 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Locust bean gum 0.2 Xanthan gum 0.4 Diglycerin 1.0 Lactobacillus / Pear Juice Ferment Filtrate 0.2 C part Phospholipid PCSH70 (Nippon Seika) 0.8 Phytopresome Cera-236 (Nippon Seika) 0.1 Glycerin 2.0 1,3-Butylene glycol 8.0 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then pass through a high-pressure emulsifier (100 MPa) twice and cool. Add part A and stir until uniform (viscosity 2000 mPa·s, pH 5.5).

[0071] Example 22: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Hexanediol 1.0 Caprylyl glycol 0.3 Purified water, in an amount that totals 100. Alcaligenes-produced polysaccharide 0.1 Xanthan gum 0.2 Hydroxypropyl methylcellulose 0.1 Tuberose polysaccharide 0.5 Sodium citrate 0.3 Appropriate amount of citric acid C part Decyl glucoside 0.5 Dipropylene glycol 2.0 Propanediol 6.0 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir with a homomixer (5000 rpm), and cool. Add part A and stir until homogeneous (viscosity 3500 mPa·s, pH 6.0).

[0072] Example 23: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.0 Part B Methylparaben 0.15 Glyceryl caprate 0.3 Purified water, in an amount that totals 100. Carrageenan 0.1 Xanthan gum 0.1 Sodium hyaluronate (molecular weight 150,000) 0.05 Glucosyltrehalose 0.5 Suizenji Nori polysaccharide 0.2 Xylitol 0.5 Erythritol 0.5 Sorbitol 0.5 Sodium citrate 0.2 Appropriate amount of citric acid C part Polyglyceryl-10 myristate 0.5 Ceteth-20 0.3 1,3-Butylene glycol 2.0 Methylgluceth-20 0.8 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir with a propeller (800 rpm), and cool. Add part A and stir until uniform (viscosity 1700 mPa·s, pH 5.0).

[0073] Example 24: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.0 Part B Phenoxyethanol 0.15 Glyceryl caprate 0.3 Purified water, in an amount that totals 100. Cyclodextrin 0.5 Sodium citrate 0.2 Appropriate amount of citric acid C part Polyglyceryl-10 laurate 0.5 Phytocompo-C (Nippon Fine Chemical) 1.0 1,3-Butylene glycol 2.0 Methylgluceth-10 0.8 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir with a propeller (800 rpm), and cool. Add part A and stir until uniform (viscosity 1700 mPa·s, pH 5.0).

[0074] Example 25: Bycell Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.0 Part B Phenoxyethanol 0.15 Glyceryl caprylate 0.3 Purified water, in an amount that totals 100. Sodium citrate 0.2 Appropriate amount of citric acid C part Polyglyceryl-10 myristate 0.8 Phytopresome Cera-236 (Nippon Seika) 0.5 1,3-Butylene glycol 10.0 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir with a propeller (800 rpm), and cool. Add part A and stir until uniform (viscosity 1700 mPa·s, pH 5.0).

[0075] Example 26: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.0 Part B Phenoxyethanol 0.15 Glyceryl caprylate 0.3 Purified water, in an amount that totals 100. Sodium lactate 0.2 Lactic acid appropriate amount Centella asiatica extract 0.1 Caffeine 0.1 C part Polysorbate 80 0.5 PEG-45 stearate 0.8 PrimeLipid PI (Nippon Fine Chemical) 0.3 1,3-Butylene glycol 8.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir with a propeller (800 rpm), and cool. Add part A and stir until uniform (viscosity 1700 mPa·s, pH 5.0).

[0076] Example 27: Lotion Component Amount (wt%) -------------------------------------- Part A Arbutin (Nippon Seika) 3.0 Part B Phenoxyethanol 0.5 Carbomer 2% solution (KOH neutralized) 8.0 Purified water, in an amount that totals 100. Pantothenyl alcohol 0.3 Trehalose 0.5 Glutamic acid 0.2 Green tea leaf extract 0.1 Rosemary leaf extract 0.1 Lemon fruit extract 0.1 Lavender flower extract 0.1 Calendula flower extract 0.1 Panax ginseng root extract 0.1 Resveratrol 0.1 C part Decyl glucoside 0.8 1,3-Butylene glycol 5.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until uniform (viscosity 8000 mPa·s).

[0077] Example 28: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 3.0 Part B Phenoxyethanol 0.5 Carbomer 2% solution (KOH neutralized) 10.0 Purified water, in an amount that totals 100. Pantothenyl alcohol 0.3 Trehalose 0.5 Glutamic acid 0.2 Green tea leaf extract 0.1 Rosemary leaf extract 0.1 Lemon fruit extract 0.1 Lavender flower extract 0.1 Calendula flower extract 0.1 Panax ginseng root extract 0.1 Resveratrol 0.1 C part Polyglyceryl-10 laurate 0.8 1,3-Butylene glycol 5.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until uniform (viscosity 8000 mPa·s).

[0078] Example 29: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 3.0 Part B Phenoxyethanol 0.5 Carbomer 2% solution (KOH neutralized) 6.0 Purified water, in an amount that totals 100. Adenosine 0.2 Nicotinamide mononucleotide 0.3 Cytidyl phosphate 2Na 0.5 Lemon fruit extract 0.1 Lavender flower extract 0.1 Calendula flower extract 0.1 Panax ginseng root extract 0.1 Resveratrol 0.1 C part Polyglyceryl-10 laurate 0.8 1,3-Butylene glycol 5.0 Bakuchiol 0.2 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until uniform (viscosity 4000 mPa·s).

[0079] Example 30: Lotion Component Amount (wt%) -------------------------------------- Part A Arbutin (Nippon Seika) 3.0 Part B Phenoxyethanol 0.5 Carbomer 2% solution (KOH neutralized) 10.0 Purified water, in an amount that totals 100. C part Ethanol 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until uniform (viscosity 8000 mPa·s).

[0080] Example 31: Lotion Component Amount (wt%) -------------------------------------- Part A Arbutin (Nippon Seika) 3.0 Nicotinamide 5.0 Part B Phenoxyethanol 0.3 Purified water, in an amount that totals 100. Sodium pyrosulfite 0.1 C part Ethanol 5.0 Polyglyceryl-10 oleate 0.3 Polysorbate 80 0.3 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until uniform.

[0081] Example 32: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.0 3-O-ethyl ascorbic acid (Nippon Seika) 1.0 Part B Phenoxyethanol 0.3 Purified water, in an amount that totals 100. Sodium citrate 0.2 Appropriate amount of citric acid EDTA-2Na 0.1 C part Polyglyceryl-10 laurate 0.5 1,3-Butylene glycol 4.0 Nicotinate tocopherol 0.15 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until homogenized (pH 4.0).

[0082] Example 33: Lotion Component Amount (wt%) -------------------------------------- Part A L-ascorbic acid 2-glucoside 2.0 Part B Glyceryl caprylate 0.5 Purified water, in an amount that totals 100. C part Polyglyceryl-10 isostearate 0.6 Sodium citrate 0.2 Appropriate amount of citric acid Etidronic acid 0.1 1,3-Butylene glycol 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until homogenized (pH 5.5).

[0083] Example 34: Lotion Component Amount (wt%) -------------------------------------- Part A Sodium tocopheryl phosphate 2.0 Nicotinamide 5.0 Part B Glyceryl caprylate 0.5 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 C part Polyglyceryl-10 laurate 0.6 1,3-Butylene glycol 3.0 Propanediol 2.0 Propylene glycol 1.0 Dipropylene glycol 0.5 Pentylene glycol 1.0 Diglycerin 0.8 Glycerin 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until uniform.

[0084] Example 35: Lotion Component Amount (wt%) -------------------------------------- Part A 4-Methoxysalicylate K 1.0 Tranexamic acid (Nippon Seika) 2.0 Part B Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Polyglyceryl-10 laurate 0.6 Neosolue-AquaS (Nippon Fine Chemical) 1.0 Neosolue-Aqulio (Nippon Seika) 1.0 Propanediol 2.0 Diglycerin 0.8 Glycerin 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until uniform.

[0085] Example 36: Lotion Component Amount (wt%) -------------------------------------- Part A 4-Methoxysalicylate K 1.0 Tranexamic acid (Nippon Seika) 2.0 Part B Phenoxyethanol 0.5 Purified water, in an amount that totals 100. Houttuynia cordata extract 1.0 C part Polyglyceryl laurate - 10 0.6 Neosolue-AquaS (Nippon Fine Chemical) 1.0 Neosolue-Aqulio (Nippon Seika) 1.0 Menthol 0.2 Eucalyptus oil 0.2 Propanediol 2.0 Diglycerin 0.8 Glycerin 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to about 80 °C respectively. Add part C to part B, stir and mix, and then cool. Add part A and stir until homogeneous.

[0086] Example 37 Lotion Component Dosage (wt%) -------------------------------------- [[ID=ll]]Part A Allantoin 0.2 Tranexamic acid (Nippon Fine Chemical) 2.0 Part B Ethylhexylglycerin 0.5 Purified water An amount to make 100 in total Part C Polyglyceryl-10 oleate 0.6 Phytocompo HS (Nippon Fine Chemical) 0.5 PrimeLipid ALPA (Nippon Fine Chemical) 0.1 Neosolue-Aqulio (Nippon Fine Chemical) 0.5 Propanediol 2.0 Glycerin 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to about 70 °C respectively. Add part C to part B, stir and mix, and then cool. Add part A and stir until homogeneous.

[0087] Example 38 Lotion Component Dosage (wt%) -------------------------------------- Part A 3-O-Ethylascorbic acid (Nippon Fine Chemical) 5.0 Salicylic acid 0.7 Glycyrrhizic acid 2K 0.1 Part B Phenoxyethanol 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Hydrolyzed collagen 0.1 Hydrolyzed hyaluronic acid 0.2 Sodium hyaluronate (molecular weight 1.5 million) 0.05 Xanthan gum 0.2 C part Polyglyceryl-10 oleate 0.6 Inulin-SC (Nippon Fine Chemical) 0.5 Propanediol 2.0 Glycerin 3.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir and mix, then cool. Add part A and stir until uniform (viscosity 1000 mPa·s).

[0088] Example 39: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Isopropylmethylphenol 0.1 Part B Phenoxyethanol 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Placenta extract 0.1 Pullulan 0.1 Tamarind seed gum 0.2 Sodium alginate 0.1 Phytic acid 0.1 C part LP70H (Nippon Seika) 0.2 Phytopresome (Nippon Seika) 0.3 Propylene glycol 5.0 Pentylene glycol 2.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat Part B and Part C to about 80°C respectively. Add Part C to Part B, stir and mix, and then cool. Add Part A and stir until uniform (viscosity 500 mPa·s, pH 6.5).

[0089] Example 40 Skin lotion Component Content (wt%) -------------------------------------- Part A Arbutin - Bio (Nippon Seika) 6.5 Part B Phenoxyethanol 0.3 Purified water An amount to make a total of 100 Tremoist - TP (Nippon Seika) 0.1 Locust bean gum 0.2 ]Xanthan gum 0.2 Part C LP70H (Nippon Seika) 0.2 Phytopresome Cera - 236 (Nippon Seika) 0.3 Propylene glycol 5.0 1,3 - Butylene glycol 5.0 Stearyl glycyrrhetinate 0.1 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat Part B and Part C to about 80°C respectively. Add Part C to Part B, stir with a homomixer (5000 rpm), and then cool. Add Part A and stir until uniform (viscosity 1600 mPa·s).

[0090] Example 41: Bycell Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.5 Part B Artemisia capillaris extract 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Heparin-like substance 0.1 Locust bean gum 0.2 Xanthan gum 0.2 C part Phytopresome Plus (Nippon Fine Chemical) 2.0 Polyglyceryl-10 myristate 0.8 Retinyl palmitate 0.1 Propylene glycol 5.0 1,3-Butylene glycol 5.0 Nicotinate tocopherol 0.2 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir with a homomixer (8000 rpm), and cool. Add part A and stir until uniform (viscosity 5000 mPa·s).

[0091] Example 42: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Artemisia capillaris extract 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Locust bean gum 0.1 Xanthan gum 0.3 C part Phytocompo-PP (Nippon Fine Chemical) 1.0 LP70H (Nippon Seika) 0.3 Plandool-LG1 (Nippon Seika) 0.5 Plandool-MAS (Nippon Seika) 0.1 Glycerin 5.0 1,3-Butylene glycol 5.0 Tocopherol nicotinate 0.1 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, mix, then pass through a high-pressure emulsifier (70 MPa) twice and cool. Add part A and stir until uniform (viscosity 2000 mPa·s).

[0092] Example 43: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.0 L-ascorbic acid 2-glucoside 2.0 Part B Clove extract 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Locust bean gum 0.2 Xanthan gum 0.4 Diglycerin 1.0 Lactobacillus / Pear Juice Ferment Filtrate 0.2 C part Phospholipid PCSH70 (Nippon Seika) 0.8 Phytopresome Cera-236 (Nippon Seika) 0.1 Glycerin 2.0 1,3-Butylene glycol 8.0 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, mix, then pass through a high-pressure emulsifier (100 MPa) twice and cool. Add part A and stir until uniform (viscosity 2000 mPa·s, pH 5.5).

[0093] Example 44: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Clove extract 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 Hydroxyethylcellulose 0.2 Locust bean gum 0.2 Xanthan gum 0.4 Diglycerin 1.0 Lactobacillus / Pear Juice Ferment Filtrate 0.2 Dipotassium glycyrrhizate 0.1 C part Phospholipid PCSH70 (Nippon Seika) 0.8 Phytopresome Cera-236 (Nippon Seika) 0.1 β-Glycyrrhetinic acid 0.1 Glycerin 2.0 1,3-Butylene glycol 8.0 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, mix, then pass through a high-pressure emulsifier (100 MPa) twice and cool. Add part A and stir until uniform (viscosity 2000 mPa·s, pH 5.5).

[0094] Example 45: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Clove extract 0.3 Purified water, in an amount that totals 100. Tremoist-TP (Nippon Fine Chemical) 0.1 (Acryloyldimethyltaurate Ammonium / VP) Copolymer 0.2 (Acryloyldimethyltaurate ammonium / Beheneth-25 Methacrylate Crosspolymer 0.1 Diglycerin 1.0 Lactobacillus / Pear Juice Ferment Filtrate 0.2 Dipotassium glycyrrhizate 0.1 C part Phospholipid PCSH70 (Nippon Seika) 0.8 Phytopresome Cera-236 (Nippon Seika) 0.1 β-Glycyrrhetinic acid 0.1 Glycerin 2.0 1,3-Butylene glycol 8.0 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, mix, then pass through a high-pressure emulsifier (100 MPa) twice and cool. Add part A and stir until uniform (viscosity 2000 mPa·s, pH 5.5).

[0095] Example 46: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Hexanediol 1.0 Caprylyl glycol 0.3 Purified water, in an amount that totals 100. Alcaligenes-produced polysaccharide 0.1 Xanthan gum 0.2 Hydroxypropyl methylcellulose 0.1 Hydroxypropyl methylcellulose stearoxy ether 0.2 Tuberose polysaccharide 0.5 Sodium citrate 0.3 Appropriate amount of citric acid C part Decyl glucoside 0.5 Dipropylene glycol 2.0 Propanediol 6.0 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, mix with a homomixer (5000 rpm), and cool. Add part A and mix until homogeneous (viscosity 3500 mPa·s, pH 6.0).

[0096] Example 47: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 2.0 Part B Hexanediol 1.0 Caprylyl glycol 0.3 Purified water, in an amount that totals 100. Alcaligenes-produced polysaccharide 0.1 (PEG-240 / Decyltetradeceth-20 / HDI) Copolymer 0.1 (Acrylates / C10-30 Alkyl Acrylate) Crosspolymer 0.1 Tuberose polysaccharide 0.5 Sodium citrate 0.3 Appropriate amount of citric acid C part Decyl glucoside 0.5 Dipropylene glycol 2.0 Propanediol 6.0 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, mix with a homomixer (5000 rpm), and cool. Add part A and mix until homogeneous (viscosity 8000 mPa·s, pH 6.0).

[0097] Example 48: Lotion Component Amount (wt%) -------------------------------------- Part A Tranexamic acid (Nippon Seika) 1.0 Part B Methylparaben 0.15 Glyceryl caprate 0.3 Purified water, in an amount that totals 100. Carbomer 2% solution (KOH neutralized) 5.0 Xanthan gum 0.1 Sodium hyaluronate (molecular weight 150,000) 0.05 Glucosyltrehalose 0.5 Suizenji Nori polysaccharide 0.2 Xylitol 0.5 Erythritol 0.5 Sorbitol 0.5 Sodium citrate 0.2 Appropriate amount of citric acid C part Polyglyceryl-10 myristate 0.5 Ceteth-20 0.3 1,3-Butylene glycol 2.0 Methylgluceth-20 0.8 Nicotinate tocopherol 0.3 -------------------------------------- (Preparation method) Heat parts B and C to approximately 80°C. Add part C to part B, stir with a propeller (800 rpm), and cool. Add part A and stir until uniform (viscosity 10000 mPa·s, pH 5.0).

[0098] Example 49 Cream Component Amount (wt%) -------------------------------------- Part A Methylparaben 0.10 Glyceryl caprate 0.3 Purified water, in an amount that totals 100. Carbomer 2% solution (KOH neutralized) 15.0 Part B Polyglyceryl-10 stearate 1.0 1,3-Butylene glycol 2.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 10000 mPa·s).

[0099] Example 50 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.4 Glyceryl caprate 0.5 Purified water, in an amount that totals 100. Carbomer 2% solution (KOH neutralized) 10.0 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 1,3-Butylene glycol 5.0 LUSPLAN DD-IS (Nippon Fine Chemical) 1.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (1000 rpm), and cool. Add part C and stir until uniform (viscosity 10000 mPa·s).

[0100] Example 51 Cream Component Amount (wt%) -------------------------------------- Part A Artemisia capillaris extract 0.5 Caprylhydroxamic acid 0.2 Purified water, in an amount that totals 100. Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Cetostearyl alcohol 4.0 1,3-Butylene glycol 5.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 6000 mPa·s).

[0101] Example 52 Cream Component Amount (wt%) -------------------------------------- Part A Artemisia capillaris extract 0.3 Phenoxyethanol 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 0.8 Polyglyceryl-5 oleate 0.5 Cetostearyl alcohol 2.0 Behenyl alcohol 1.0 1,3-Butylene glycol 5.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 6000 mPa·s).

[0102] Example 53 Cream Component Amount (wt%) -------------------------------------- Part A Artemisia capillaris extract 0.5 Ethylhexylglycerin 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Stearyl alcohol 2.5 Behenyl alcohol 1.0 Arachidyl alcohol 1.5 1,3-Butylene glycol 7.0 Squalane 10.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 6000 mPa·s).

[0103] Example 54 Cream Component Amount (wt%) -------------------------------------- Part A Artemisia capillaris extract 0.5 Caprylhydroxamic acid 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Stearyl alcohol 3.5 Behenyl alcohol 1.5 Plandool-LG1 (Nippon Seika) 0.5 Plandool-LG2 (Nippon Seika) 0.5 Plandool-LG3 (Nippon Seika) 0.5 Plandool-LG4 (Nippon Seika) 0.5 1,3-Butylene glycol 7.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a disperser (3000 rpm), and cool. Add part C and stir until uniform (viscosity 15000 mPa·s).

[0104] Example 55 Cream Component Amount (wt%) -------------------------------------- Part A Clove extract 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Stearyl alcohol 2.5 Behenyl alcohol 0.5 Plandool-G (Nippon Fine Chemical) 0.5 Plandool-H (Nippon Fine Chemical) 0.5 Plandool-ISS (Nippon Fine Chemical) 0.5 Plandool-LG4 (Nippon Seika) 0.5 Plandool-SUM (Nippon Seika) 0.5 Tocopherol 0.3 1,3-Butylene glycol 7.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 20000 mPa·s).

[0105] Example 56 Cream Component Amount (wt%) -------------------------------------- Part A Clove extract 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Stearyl alcohol 2.5 Arachidyl alcohol 1.0 Plandool-G (Nippon Fine Chemical) 0.5 Plandool-H (Nippon Fine Chemical) 0.5 Plandool-ISS (Nippon Fine Chemical) 0.5 Plandool-LG4 (Nippon Seika) 0.5 Plandool-SUM (Nippon Seika) 0.5 Tocopherol 0.3 1,3-Butylene glycol 7.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 6000 mPa·s).

[0106] Example 57 Cream Component Amount (wt%) -------------------------------------- Part A Clove extract 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 1.2 Glyceryl stearate 0.5 Cetyl palmitate 1.0 Plandool-G (Nippon Fine Chemical) 0.5 Plandool-H (Nippon Fine Chemical) 0.5 Vaseline 2.0 1,3-Butylene glycol 7.0 Squalane 6.0 Tocopherol nicotinate 0.1 Tocopherol acetate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 30000 mPa·s).

[0107] Example 58 Cream Component Amount (wt%) -------------------------------------- Part A Clove extract 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Hydroxyproline 0.1 Part B Polyglyceryl-10 stearate 1.2 Glyceryl stearate 0.5 Cetyl palmitate 1.0 Sunflower seed wax 0.5 Rice bran wax 0.2 Sunflower seed oil 1.0 Almond oil 1.0 Jojoba oil 0.5 Carnauba wax 0.5 1,3-Butylene glycol 7.0 Squalane 9.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 60000 mPa·s).

[0108] Example 59 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Guar gum 0.2 Treoist-TP (Nippon Fine Chemical) 0.2 Hydrolyzed hydrogenated starch 0.1 Part B Sodium stearoyl methyl taurate 1.2 Glyceryl stearate (SE) 0.5 Polyglyceryl-2 isostearate 0.2 Cetanol 2.0 Hydrogenated rapeseed alcohol 1.0 Rysterol ester 0.5 Rice bran oil 3.0 γ-oryzanol 0.2 Broccoli seed oil 0.5 Cholesterol 0.5 Oleyl alcohol 0.2 Ethylhexyl palmitate 3.0 1,3-Butylene glycol 7.0 Cetyl ethylhexanoate 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 30000 mPa·s).

[0109] Example 60 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Alcaligenes-produced polysaccharide 0.05 Treoist-TP (Nippon Fine Chemical) 0.2 Hydrolyzed hydrogenated starch 0.1 Part B Polysorbate 80 1.5 Ceteth-20 1.0 PEG-20 Hydrogenated Castor Oil 0.5 Cetyl palmitate 1.0 Ubiquinone 0.3 Ethylhexyl palmitate 5.0 Isononyl isononate 3.0 Sphinganin 0.1 1,3-Butylene glycol 7.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0110] Example 61 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Sodium acetylated hyaluronate 0.2 Glycerin 4.0 Part B Sorbitan stearate 1.0 Polysorbate 20 0.6 Polyglyceryl-2 isostearate 0.4 Cetostearyl alcohol 2.0 Camellia oil 0.3 Hydrogenated polydecene 5.0 Caprylic / Capric Triglyceride 3.0 Dimethicone (2 cases) 0.1 1,3-Butylene glycol 7.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 7000 mPa·s).

[0111] Example 62 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.3 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Sodium acetylated hyaluronate 0.2 Glycerin 4.0 Part B Phospholipid PCSH70 (Nippon Seika) 1.0 Polyglyceryl-10 stearate 0.6 Polyglyceryl-5 oleate 0.3 Stearyl alcohol 2.0 Lanolin 0.3 Liquid lanolin 0.2 Hard lanolin 0.5 Caprylic / Capric Triglyceride 2.0 Lanolin Row 0.5 Tocopherol 0.5 Argania spinosa kernel oil 0.5 Ascorbyl tetrahexyldecanoate 3.0 1,3-Butylene glycol 3.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0112] Example 63 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Glycerin 4.0 Part B Phytocompo-PP (Nippon Fine Chemical) 0.5 Polyglyceryl-5 oleate 0.3 Stearyl alcohol 2.0 Caprylic / Capric Triglyceride 2.0 Argania spinosa kernel oil 0.5 Ascorbyl tetrahexyldecanoate 3.0 1,3-Butylene glycol 3.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0113] Example 64 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Part B Phytocompo-PP (Nippon Fine Chemical) 0.5 Polyglyceryl-5 oleate 0.3 Glycerin 8.0 Stearyl alcohol 2.0 Caprylic / Capric Triglyceride 2.0 Hydrogenated farnesene 2.0 Ascorbyl tetrahexyldecanoate 3.0 1,3-Butylene glycol 9.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0114] Example 65 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Part B Phytocompo-C (Nippon Fine Chemical) 0.5 Phytocompo HS (Nippon Fine Chemical) 1.0 Glycerin 8.0 Stearyl alcohol 2.0 Caprylic / Capric Triglyceride 2.0 Astaxanthin 0.1 Plandool-DP (Nippon Fine Chemical) 0.5 Methylheptyl laurate 1.2 Methylheptyl myristate 1.0 Isobutyl isostearate 1.0 Glyceryl triisostearate 0.5 1,3-Butylene glycol 9.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0115] Example 66 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. PrimeLipid ALPA (Nippon Fine Chemical) 0.1 Myrtle fruit extract 1.0 White birch sap 0.5 Grape fruit extract 0.2 Licorice leaf extract 0.1 Part B Phytocompo-C (Nippon Fine Chemical) 1.5 Phytopresome (Nippon Seika) 0.2 Glycerin 8.0 Cetostearyl alcohol 2.0 Dimethicone (50 sq.) 2.0 Cyclomethicone 0.5 Astaxanthin 0.1 Myristyl isooctanoate 0.5 Methylheptyl laurate 1.2 Methylheptyl myristate 1.0 Isobutyl isostearate 1.0 Glyceryl triisostearate 0.5 1,3-Butylene glycol 9.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0116] Example 67 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Purified water, in an amount that totals 100. Glycerin 3.0 Grape fruit extract 0.2 (Sodium acrylate / sodium acryloyldimethyl taurate) copolymer 0.1 Part B PEG / PPG-20 / 20 Dimethicone 1.0 PEG-12 Dimethicone 0.2 PEG-10 Dimethicone 0.2 (Dimethicone / PEG-10 / 15) Crosspolymer 0.2 Cetostearyl alcohol 2.0 Dimethicone (100 sq.) 2.0 Cyclomethicone 1.0 Phenylentrimethicone 0.5 Diisopropyl sebacate (Nippon Seika) 2.0 Methylheptyl laurate 1.2 1,3-Butylene glycol 4.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0117] Example 68 Cream Component Amount (wt%) -------------------------------------- Part A Methylparaben 0.10 Glyceryl caprate 0.3 Purified water, in an amount that totals 100. Carbomer 2% solution (KOH neutralized) 15.0 Part B Polyglyceryl-10 stearate 1.0 1,3-Butylene glycol 2.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Arbutin (Nippon Seika) 3.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 10000 mPa·s).

[0118] Example 69 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.4 Glyceryl caprate 0.5 Purified water, in an amount that totals 100. Carbomer 2% solution (KOH neutralized) 10.0 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 1,3-Butylene glycol 5.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Arbutin (Nippon Seika) 3.0 Tranexamic acid (Nippon Seika) 1.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 10000 mPa·s).

[0119] Example 70 Cream Component Amount (wt%) -------------------------------------- Part A Artemisia capillaris extract 0.5 Caprylhydroxamic acid 0.2 Purified water, in an amount that totals 100. Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Cetostearyl alcohol 4.0 1,3-Butylene glycol 5.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Arbutin (Nippon Seika) 6.0 Salicylic acid 0.7 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 6000 mPa·s).

[0120] Example 71 Cream Component Amount (wt%) -------------------------------------- Part A Artemisia capillaris extract 0.5 Purified water, in an amount that totals 100. Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Cetostearyl alcohol 3.5 1,3-Butylene glycol 5.0 Pentaerythrityl tetraethylhexanoate (Nippon Seika) 1.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Arbutin (Nippon Seika) 6.0 Allantoin 0.2 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 6000 mPa·s).

[0121] Example 72 Cream Component Amount (wt%) -------------------------------------- Part A Artemisia capillaris extract 0.3 Phenoxyethanol 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 0.8 Polyglyceryl-5 oleate 0.5 Cetostearyl alcohol 2.0 Behenyl alcohol 1.0 1,3-Butylene glycol 5.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 Nicotinamide 5.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 6000 mPa·s).

[0122] Example 73 Cream Component Amount (wt%) -------------------------------------- Part A Artemisia capillaris extract 0.5 Ethylhexylglycerin 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Stearyl alcohol 2.5 Behenyl alcohol 1.0 Arachidyl alcohol 1.5 1,3-Butylene glycol 7.0 Squalane 10.0 Tocopherol nicotinate 0.1 Tocopherol acetate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 Nicotinamide 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 6000 mPa·s).

[0123] Example 74 Cream Component Amount (wt%) -------------------------------------- Part A Artemisia capillaris extract 0.5 Caprylhydroxamic acid 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Stearyl alcohol 3.5 Behenyl alcohol 1.5 Plandool-LG1 (Nippon Seika) 0.5 Plandool-LG2 (Nippon Seika) 0.5 Plandool-LG3 (Nippon Seika) 0.5 Plandool-LG4 (Nippon Seika) 0.5 1,3-Butylene glycol 7.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 4-Methoxysalicylate K 1.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a propeller (800 rpm), and cool. Add part C and stir until uniform (viscosity 15000 mPa·s).

[0124] Example 75 Cream Component Amount (wt%) -------------------------------------- Part A Clove extract 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Stearyl alcohol 2.5 Behenyl alcohol 0.5 Plandool-G (Nippon Fine Chemical) 0.5 Plandool-H (Nippon Fine Chemical) 0.5 Plandool-ISS (Nippon Fine Chemical) 0.5 Plandool-LG4 (Nippon Seika) 0.5 Plandool-SUM (Nippon Seika) 0.5 Tocopherol 0.3 1,3-Butylene glycol 7.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 Sodium tocopheryl phosphate 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 20000 mPa·s).

[0125] Example 76 Cream Component Amount (wt%) -------------------------------------- Part A Clove extract 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Appropriate amount of citric acid Sodium citrate 0.3 Part B Polyglyceryl-10 stearate 1.0 Polyglyceryl-5 oleate 0.8 Stearyl alcohol 2.5 Arachidyl alcohol 1.0 Plandool-G (Nippon Fine Chemical) 0.5 Plandool-H (Nippon Fine Chemical) 0.5 Plandool-ISS (Nippon Fine Chemical) 0.5 Plandool-LG4 (Nippon Seika) 0.5 Plandool-SUM (Nippon Seika) 0.5 Tocopherol 0.3 1,3-Butylene glycol 7.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part L-ascorbic acid 2-glucoside 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until homogeneous (viscosity 6000 mPa·s, pH 5.0).

[0126] Example 77 Cream Component Amount (wt%) -------------------------------------- Part A Clove extract 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Succinic acid (appropriate amount) Disodium succinate 0.2 Part B Polyglyceryl-10 stearate 1.2 Glyceryl stearate 0.5 Cetyl palmitate 1.0 Plandool-G (Nippon Fine Chemical) 0.5 Plandool-H (Nippon Fine Chemical) 0.5 Vaseline 2.0 1,3-Butylene glycol 7.0 Squalane 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 1.0 3-O-ethyl ascorbic acid (Nippon Seika) 1.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until homogenized (viscosity 30000 mPa·s, pH 4.0).

[0127] Example 78 Cream Component Amount (wt%) -------------------------------------- Part A Clove extract 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Hydroxyproline 0.1 Appropriate amount of citric acid Sodium citrate 0.3 Part B Polyglyceryl-10 stearate 1.2 Glyceryl stearate 0.5 Cetyl palmitate 1.0 Sunflower seed wax 0.5 Rice bran wax 0.2 Sunflower seed oil 1.0 Almond oil 1.0 Jojoba oil 0.5 Carnauba wax 0.5 1,3-Butylene glycol 7.0 Squalane 9.0 Tocopherol nicotinate 0.1 C part 3-O-ethyl ascorbic acid (Nippon Seika) 1.0 Nicotinamide 5.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until homogenized (viscosity 60000 mPa·s, pH 4.5).

[0128] Example 79 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Guar gum 0.2 Treoist-TP (Nippon Fine Chemical) 0.2 Hydrolyzed hydrogenated starch 0.1 Appropriate amount of citric acid Sodium citrate 0.3 EDTA-2Na 0.2 Part B Sodium stearoyl methyl taurate 1.2 Glyceryl stearate (SE) 0.5 Polyglyceryl-2 isostearate 0.2 Cetanol 2.0 Hydrogenated rapeseed alcohol 1.0 Rysterol ester 0.5 Rice bran oil 3.0 γ-oryzanol 0.2 Broccoli seed oil 0.5 Cholesterol 0.5 Oleyl alcohol 0.2 Ethylhexyl palmitate 3.0 1,3-Butylene glycol 7.0 Cetyl ethylhexanoate 6.0 Tocopherol nicotinate 0.1 C part Arbutin (Nippon Seika) 3.0 Tranexamic acid (Nippon Seika) 1.0 3-O-ethyl ascorbic acid (Nippon Seika) 1.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until homogenized (viscosity 30000 mPa·s, pH 4.5).

[0129] Example 80 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Alcaligenes-produced polysaccharide 0.05 Treoist-TP (Nippon Fine Chemical) 0.2 Hydrolyzed hydrogenated starch 0.1 Part B Polysorbate 80 1.5 Ceteth-20 1.0 PEG-20 Hydrogenated Castor Oil 0.5 Cetyl palmitate 1.0 Ubiquinone 0.3 Ethylhexyl palmitate 5.0 Isononyl isononate 3.0 Sphinganin 0.1 1,3-Butylene glycol 7.0 Tocopherol nicotinate 0.1 C part Arbutin (Nippon Seika) 3.0 Dipotassium glycyrrhizate 0.1 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0130] Example 81 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Sodium acetylated hyaluronate 0.2 Glycerin 4.0 Appropriate amount of citric acid Sodium citrate 0.3 EDTA-2Na 0.2 Part B Sorbitan stearate 1.0 Polysorbate 20 0.6 Polyglyceryl-2 isostearate 0.4 Cetostearyl alcohol 2.0 Diethylhexyl sebacate (Nippon Seika) 0.3 Hydrogenated polydecene 5.0 Caprylic / Capric Triglyceride 3.0 Dimethicone (2 cases) 0.1 1,3-Butylene glycol 7.0 Tocopherol nicotinate 0.1 C part 3-O-ethyl ascorbic acid (Nippon Seika) 1.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until homogeneous (viscosity 7000 mPa·s, pH 5.0).

[0131] Example 82 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.3 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Sodium acetylated hyaluronate 0.2 Glycerin 4.0 Part B Phospholipid PCSH70 (Nippon Seika) 1.0 Polyglyceryl-10 stearate 0.6 Polyglyceryl-5 oleate 0.3 Stearyl alcohol 2.0 Lanolin 0.3 Liquid lanolin 0.2 Hard lanolin 0.5 Pentaerythrityl tetraethylhexanoate (Nippon Seika) 2.0 Lanolin Row 0.5 Tocopherol 0.5 Argania spinosa kernel oil 0.5 Ascorbyl tetrahexyldecanoate 3.0 1,3-Butylene glycol 3.0 Tocopherol nicotinate 0.1 C part Arbutin (Nippon Seika) 3.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0132] Example 83 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Glycerin 4.0 Part B Phytocompo-PP (Nippon Fine Chemical) 0.5 Polyglyceryl-5 oleate 0.3 Stearyl alcohol 2.0 Caprylic / Capric Triglyceride 2.0 Argania spinosa kernel oil 0.5 Ascorbyl tetrahexyldecanoate 3.0 1,3-Butylene glycol 3.0 Tocopherol nicotinate 0.1 C part L-ascorbic acid 2-glucoside 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until homogenized (viscosity 3000 mPa·s, pH 5.5).

[0133] Example 84 Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Part B Phytocompo-PP (Nippon Fine Chemical) 0.5 Polyglyceryl-5 oleate 0.3 Glycerin 8.0 Stearyl alcohol 2.0 Caprylic / Capric Triglyceride 2.0 Hydrogenated farnesene 2.0 Ascorbyl tetrahexyldecanoate 3.0 1,3-Butylene glycol 9.0 Tocopherol nicotinate 0.1 C part L-ascorbic acid 2-glucoside 2.0 Dipotassium glycyrrhizate 0.1 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0134] Example 85 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 0.5 Part B Phytocompo-C (Nippon Fine Chemical) 0.5 Phytocompo HS (Nippon Fine Chemical) 1.0 Glycerin 8.0 Stearyl alcohol 2.0 Caprylic / Capric Triglyceride 2.0 Astaxanthin 0.1 Myristyl isooctanoate 0.5 Methylheptyl laurate 1.2 Methylheptyl myristate 1.0 Isobutyl isostearate 1.0 Glyceryl triisostearate 0.5 1,3-Butylene glycol 9.0 Tocopherol nicotinate 0.1 C part Arbutin (Nippon Seika) 3.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0135] Example 86 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. PrimeLipid ALPA (Nippon Fine Chemical) 0.1 Myrtle fruit extract 1.0 White birch sap 0.5 Grape fruit extract 0.2 Licorice leaf extract 0.1 Part B Phytocompo-C (Nippon Fine Chemical) 1.5 Phytopresome (Nippon Seika) 0.2 Glycerin 8.0 Cetostearyl alcohol 2.0 Dimethicone (50 sq.) 2.0 Cyclomethicone 0.5 Astaxanthin 0.1 Myristyl isooctanoate 0.5 Methylheptyl laurate 1.2 Methylheptyl myristate 1.0 Isobutyl isostearate 1.0 Glyceryl triisostearate 0.5 1,3-Butylene glycol 9.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 Pantothenyl alcohol 0.3 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0136] Example 87 Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Purified water, in an amount that totals 100. Glycerin 3.0 Grape fruit extract 0.2 (Sodium acrylate / sodium acryloyldimethyl taurate) copolymer 0.1 Part B PEG / PPG-20 / 20 Dimethicone 1.0 PEG-12 Dimethicone 0.2 PEG-10 Dimethicone 0.2 (Dimethicone / PEG-10 / 15) Crosspolymer 0.2 Cetostearyl alcohol 2.0 Dimethicone (100 sq.) 2.0 Cyclomethicone 1.0 Phenylentrimethicone 0.5 Diisopropyl sebacate (Nippon Seika) 2.0 Methylheptyl laurate 1.2 1,3-Butylene glycol 4.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 Allantoin 0.3 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0137] Example 88: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (2 cases) 20.0 Diisopropyl sebacate (Nippon Seika) 10.0 Cetyl ethylhexanoate 15.0 LUSPLAN DD-DHR (Nippon Seika) 2.0 Phenylentrimethicone 3.0 (Dimethicone / PEG-10 / 15) Crosspolymer 0.5 PEG-9 Polydimethylsiloxyethyl Dimethicone 0.4 STR-100A-LP (manufactured by Sakai Chemical Industry Co., Ltd.) 5.0 (Titanium dioxide, hydrated silica, aluminum hydroxide, hydrogen dimethicone) FINEX-50W-LP2 (manufactured by Sakai Chemical Industry Co., Ltd.) 5.0 (Zinc oxide, hydrated silica, hydrogen dimethicone) Tocopherol 0.2 Tocopherol nicotinate 0.1 Part B 1,3-Butylene glycol 10.0 Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Tranexamic acid (Nippon Seika) 2.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0138] Example 89: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (10cs) 10.0 Diisopropyl sebacate (Nippon Seika) 5.0 Caprylyl methicone 10.0 (Hydrolyzed Silk / PG Propylmethylsilanediol) Crosspolymer 2.0 PEG-10 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 3.0 Ethylhexyl methoxycinnamate 6.0 STR-100A-LP (manufactured by Sakai Chemical Industry Co., Ltd.) 7.0 (Titanium dioxide, hydrated silica, aluminum hydroxide, hydrogen dimethicone) FINEX-50W-LP2 (manufactured by Sakai Chemical Industry Co., Ltd.) 6.0 (Zinc oxide, hydrated silica, hydrogen dimethicone) Silica (Godball G-6C, manufactured by Suzuki Oil & Fat Industry Co., Ltd.) 1.0 Nicotinate tocopherol 0.2 Part B 1,3-Butylene glycol 10.0 Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Tranexamic acid (Nippon Seika) 2.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0139] Example 90: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (50cs) 5.0 Caprylylmethicone 6.0 (Hydrolyzed Silk / PG Propylmethylsilanediol) Crosspolymer 2.0 PEG-10 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 3.0 Ethylhexyl methoxycinnamate 6.0 Bis-ethylhexyloxyphenol methoxyphenyl triazine 2.0 STR-100C-LF (manufactured by Sakai Chemical Industry Co., Ltd.) 6.0 (Titanium dioxide, aluminum hydroxide, stearic acid) FINEX-50-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 5.0 (Zinc oxide, triethoxycaprylylsilane) LUSPLAN DD-DA5 (Nippon Seika) 0.5 LUSPLAN DD-DA7 (Nippon Fine Chemical) 0.5 LUSPLAN SR-DM4 (Nippon Seika) 0.1 Plandool-LG1 (Nippon Seika) 0.8 Tocopherol nicotinate 0.1 Part B Glycerin 4.0 Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Tranexamic acid (Nippon Seika) 2.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0140] Example 91: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (50cs) 10.0 Caprylyl methicone 10.0 Methylheptyl laurate 5.0 (Vinyl dimethicone / methicone silsesquioxane) crosspolymer 1.0 PEG-12 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1.5 Polyhydroxystearic acid 0.5 (Palmitic acid / 2-ethylhexanoic acid) dextrin 1.0 Ethylhexyl methoxycinnamate 6.0 Octocrelin 2.0 Diethylaminohydroxybenzoyl hexyl benzoate 3.0 FINEX-50-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 10.0 (Zinc oxide, triethoxycaprylylsilane) STR-100W-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 10.0 (Titanium dioxide, hydrated silica, triethoxycaprylylsilane) Plandool-H (Nippon Fine Chemical) 0.8 Plandool-G (Nippon Fine Chemical) 1.0 LUSPLAN PI-DA (Nippon Fine Chemical) 1.0 Plandool-MAS (Nippon Seika) 1.0 Tocopherol nicotinate 0.1 Part B Glycerin 6.0 Xanthan gum 0.1 Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Tranexamic acid (Nippon Seika) 2.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0141] Example 92: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (50cs) 10.0 Caprylyl methicone 10.0 Methylheptyl laurate 5.0 (Vinyl dimethicone / methicone silsesquioxane) crosspolymer 1.0 PEG-12 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1.5 Polyhydroxystearic acid 0.5 (Palmitic acid / 2-ethylhexanoic acid) dextrin 1.0 FINEX-50-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 12.0 (Zinc oxide, triethoxycaprylylsilane) STR-100W-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 8.0 (Titanium dioxide, hydrated silica, triethoxycaprylylsilane) Plandool-LG2 (Nippon Seika) 1.0 LUSPLAN DD-IS (Nippon Fine Chemical) 1.0 LUSPLAN PI-DA (Nippon Fine Chemical) 1.0 Plandool-MAS (Nippon Seika) 1.0 Tocopherol nicotinate 0.1 Part B Glycerin 6.0 Glyceryl caprate 0.5 Purified water, in an amount that totals 100. C part Tranexamic acid (Nippon Seika) 2.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0142] Example 93: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (2 cases) 10.0 Diisopropyl sebacate (Nippon Seika) 10.0 Cetyl ethylhexanoate 15.0 Phenylentrimethicone 1.0 (Dimethicone / PEG-10 / 15) Crosspolymer 0.5 PEG-9 Polydimethylsiloxyethyl Dimethicone 0.4 STR-100A-LP (manufactured by Sakai Chemical Industry Co., Ltd.) 5.0 (Titanium dioxide, hydrated silica, aluminum hydroxide, hydrogen dimethicone) FINEX-50W-LP2 (manufactured by Sakai Chemical Industry Co., Ltd.) 5.0 (Zinc oxide, hydrated silica, hydrogen dimethicone) Tocopherol 0.2 Tocopherol nicotinate 0.1 Part B 1,3-Butylene glycol 10.0 Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Arbutin (Nippon Seika) 3.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0143] Example 94: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (10cs) 10.0 Diisopropyl sebacate (Nippon Seika) 5.0 Diethylhexyl succinate (Nippon Seika) 2.0 Caprylyl methicone 10.0 (Hydrolyzed Silk / PG Propylmethylsilanediol) Crosspolymer 2.0 PEG-10 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 3.0 Ethylhexyl methoxycinnamate 6.0 STR-100A-LP (manufactured by Sakai Chemical Industry Co., Ltd.) 7.0 (Titanium dioxide, hydrated silica, aluminum hydroxide, hydrogen dimethicone) FINEX-50W-LP2 (manufactured by Sakai Chemical Industry Co., Ltd.) 6.0 (Zinc oxide, hydrated silica, hydrogen dimethicone) Silica (manufactured by Suzuki Oil & Fat Industry, Godball G-6C) 1.0 Nicotinate tocopherol 0.2 Part B 1,3-Butylene glycol 10.0 Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Tranexamic acid (Nippon Seika) 1.0 Arbutin (Nippon Seika) 3.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0144] Example 95: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (50cs) 5.0 Caprylylmethicone 6.0 (Hydrolyzed Silk / PG Propylmethylsilanediol) Crosspolymer 2.0 PEG-10 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 3.0 Ethylhexyl methoxycinnamate 6.0 Bis-ethylhexyloxyphenol methoxyphenyl triazine 2.0 STR-100C-LF (manufactured by Sakai Chemical Industry Co., Ltd.) 6.0 (Titanium dioxide, aluminum hydroxide, stearic acid) FINEX-50-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 5.0 (Zinc oxide, triethoxycaprylylsilane) LUSPLAN DD-DA5 (Nippon Seika) 0.5 LUSPLAN DD-DA7 (Nippon Fine Chemical) 0.5 LUSPLAN SR-DM4 (Nippon Seika) 0.1 Plandool-LG1 (Nippon Seika) 0.8 Tocopherol nicotinate 0.1 Part B Glycerin 4.0 Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Tranexamic acid (Nippon Seika) 2.0 4-Methoxysalicylate K 1.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0145] Example 96: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (50cs) 10.0 Caprylyl methicone 10.0 Methylheptyl laurate 5.0 (Vinyl dimethicone / methicone silsesquioxane) crosspolymer 1.0 PEG-12 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1.5 Polyhydroxystearic acid 0.5 (Palmitic acid / 2-ethylhexanoic acid) dextrin 1.0 Ethylhexyl methoxycinnamate 6.0 Octocrelin 2.0 Diethylaminohydroxybenzoyl hexyl benzoate 3.0 FINEX-50-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 10.0 (Zinc oxide, triethoxycaprylylsilane) STR-100W-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 10.0 (Titanium dioxide, hydrated silica, triethoxycaprylylsilane) Plandool-H (Nippon Fine Chemical) 0.8 Plandool-G (Nippon Fine Chemical) 1.0 LUSPLAN PI-DA (Nippon Fine Chemical) 1.0 Plandool-MAS (Nippon Seika) 1.0 Tocopherol nicotinate 0.1 Part B Glycerin 6.0 Xanthan gum 0.1 Phenoxyethanol 0.5 Purified water, in an amount that totals 100. C part Tranexamic acid (Nippon Seika) 2.0 Nicotinamide 5.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0146] Example 97: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (50cs) 10.0 Caprylyl methicone 10.0 Methylheptyl laurate 5.0 (Vinyl dimethicone / methicone silsesquioxane) crosspolymer 1.0 PEG-12 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1.5 Polyhydroxystearic acid 0.5 (Palmitic acid / 2-ethylhexanoic acid) dextrin 1.0 FINEX-50-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 12.0 (Zinc oxide, triethoxycaprylylsilane) STR-100W-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 8.0 (Titanium dioxide, hydrated silica, triethoxycaprylylsilane) Plandool-LG2 (Nippon Seika) 1.0 Plandool-DP (Nippon Fine Chemical) 1.0 LUSPLAN PI-DA (Nippon Fine Chemical) 1.0 Plandool-MAS (Nippon Seika) 1.0 Tocopherol nicotinate 0.1 Part B Glycerin 6.0 Glyceryl caprate 0.5 Purified water, in an amount that totals 100. C part Tranexamic acid (Nippon Seika) 2.0 Allantoin 0.3 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0147] Example 98: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (50cs) 10.0 Caprylyl methicone 10.0 Methylheptyl laurate 5.0 (Vinyl dimethicone / methicone silsesquioxane) crosspolymer 1.0 PEG-12 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1.5 Polyhydroxystearic acid 0.5 (Palmitic acid / 2-ethylhexanoic acid) dextrin 1.0 FINEX-50-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 12.0 (Zinc oxide, triethoxycaprylylsilane) STR-100W-OTS (manufactured by Sakai Chemical Industry Co., Ltd.) 8.0 (Titanium dioxide, hydrated silica, triethoxycaprylylsilane) Plandool-G (Nippon Fine Chemical) 1.0 LUSPLAN PI-DA (Nippon Fine Chemical) 1.0 Plandool-MAS (Nippon Seika) 1.0 Tocopherol nicotinate 0.1 Part B Glycerin 6.0 Glyceryl caprate 0.5 Purified water, in an amount that totals 100. Appropriate amount of citric acid Sodium citrate 0.2 C part L-ascorbic acid 2-glucoside 2.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0148] Example 99: Sunscreen Component Amount (mass%) ------------------------------------- Part A Dimethicone (50cs) 10.0 Caprylyl methicone 10.0 Methylheptyl laurate 5.0 (Vinyl dimethicone / methicone silsesquioxane) crosspolymer 1.0 PEG-12 Dimethicone 1.5 Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1.5 Polyhydroxystearic acid 0.5 (Palmitic acid / 2-ethylhexanoic acid) dextrin 1.0 Ethylhexyl methoxycinnamate 6.0 Octocrelin 2.0 Diethylaminohydroxybenzoyl hexyl benzoate 3.0 Plandool-LG2 (Nippon Seika) 1.0 Plandool-MAS (Nippon Seika) 1.0 Tocopherol nicotinate 0.1 Part B Glycerin 6.0 Glyceryl caprate 0.5 Purified water, in an amount that totals 100. Appropriate amount of citric acid Sodium citrate 0.2 C part L-ascorbic acid 2-glucoside 2.0 ------------------------------------- (Preparation method) Heat part A to 80°C while stirring uniformly. Add part B to part A while stirring. After cooling, add part C and stir until uniform.

[0149] Example 100 UV cream Component Amount (wt%) -------------------------------------- Part A Clove extract 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Xanthan gum 0.2 Appropriate amount of citric acid Sodium citrate 0.3 STR-100W (manufactured by Sakai Chemical Industry Co., Ltd.) 10.0 (Titanium dioxide, hydrated silica) DIF-AB-33W (manufactured by Sakai Chemical Industry Co., Ltd.) 12.0 (Zinc oxide, hydrated silica, hydrogen dimethicone, water, BG, PEG-9 dimethicone) Part B Polyglyceryl-10 stearate 1.2 Glyceryl stearate 0.5 Cetyl palmitate 1.0 Ethylhexyl methoxycinnamate 5.0 1,3-Butylene glycol 7.0 Squalane 4.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 2.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until homogenized (viscosity 60000 mPa·s, pH 6.0).

[0150] Example 101: UV Cream Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. DIS-AB-10W (manufactured by Sakai Chemical Industry Co., Ltd.) 20.0 (Titanium dioxide, hydrated silica, hydrogen dimethicone, water, BG, PEG-9 dimethicone) DIF-AB-33W (manufactured by Sakai Chemical Industry Co., Ltd.) 16.0 (Zinc oxide, hydrated silica, hydrogen dimethicone, water, BG, PEG-9 dimethicone) Treoist-TP (Nippon Fine Chemical) 0.2 Appropriate amount of citric acid Sodium citrate 0.3 EDTA-2Na 0.2 Part B Sodium stearoyl methyl taurate 1.2 Glyceryl stearate (SE) 0.5 Polyglyceryl-2 isostearate 0.2 Cetanol 2.0 Hydrogenated rapeseed alcohol 1.0 γ-oryzanol 0.2 Cholesterol 0.5 Ethylhexyl palmitate 3.0 1,3-Butylene glycol 7.0 Diethylhexyl sebacate (Nippon Seika) 6.0 Tocopherol nicotinate 0.1 C part Tranexamic acid (Nippon Seika) 1.0 3-O-ethyl ascorbic acid (Nippon Seika) 1.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until homogenized (viscosity 30000 mPa·s, pH 4.5).

[0151] Example 102 UV Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Alcaligenes-produced polysaccharide 0.05 STR-100W (manufactured by Sakai Chemical Industry Co., Ltd.) 5.0 (Titanium dioxide, hydrated silica) DIF-AB-33W (manufactured by Sakai Chemical Industry Co., Ltd.) 10.0 (Zinc oxide, hydrated silica, hydrogen dimethicone, water, BG, PEG-9 dimethicone) Part B Polysorbate 80 1.5 Ceteth-20 1.0 PEG-20 Hydrogenated Castor Oil 0.5 Cetyl palmitate 1.0 Ubiquinone 0.3 Ethylhexyl palmitate 5.0 Diethylhexyl succinate (Nippon Seika) 3.0 Octocrylene 3.0 Ethylhexyl Methoxycinnamate 3.0 1,3-Butylene glycol 7.0 Tocopherol nicotinate 0.1 C part Arbutin (Nippon Seika) 3.0 Dipotassium glycyrrhizate 0.1 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until uniform (viscosity 3000 mPa·s).

[0152] Example 103 UV Emulsion Component Amount (wt%) -------------------------------------- Part A Phenoxyethanol 0.5 Glyceryl caprylate 0.2 Purified water, in an amount that totals 100. Inulin-SC (Nippon Fine Chemical) 1.0 Sodium acetylated hyaluronate 0.2 Glycerin 4.0 Appropriate amount of citric acid Sodium citrate 0.3 EDTA-2Na 0.2 DIS-AB-10W (manufactured by Sakai Chemical Industry Co., Ltd.) 10.0 (Titanium dioxide, hydrated silica, hydrogen dimethicone, water, BG, PEG-9 dimethicone) DIF-AB-33W (manufactured by Sakai Chemical Industry Co., Ltd.) 8.0 (Zinc oxide, hydrated silica, hydrogen dimethicone, water, BG, PEG-9 dimethicone) Part B Sorbitan stearate 1.0 Polysorbate 20 0.6 Polyglyceryl-2 isostearate 0.4 Cetostearyl alcohol 2.0 Hydrogenated polydecene 5.0 Caprylic / Capric Triglyceride 3.0 Dimethicone (2 cases) 0.1 1,3-Butylene glycol 7.0 Tocopherol nicotinate 0.1 C part 3-O-ethyl ascorbic acid (Nippon Seika) 1.0 -------------------------------------- (Preparation method) Heat parts A and B to approximately 80°C. Add part B to part A, stir with a homomixer (5000 rpm), and cool. Add part C and stir until homogenized (viscosity 7000 mPa·s, pH 4.0).

[0153] In the above formulation, the details of the ingredients listed under the product name are as follows: Arbutin-Bio: Arbutin ○Inulin-SC: Inulin 〇LP70H: Hydrogenated Lysolecithin 〇LUSPLAN DD-IS: Dimer Dilinoleyl Diisostearate 〇LUSPLAN PI-DA: Dimer dilinoleate di(isostearyl / phytosteryl) LUSPLAN DD-DHR: Dimer Dilinoleyl Hydrogenated Rosin Condensate LUSPLAN DD-DA5: Dimer Dilinoleyl Dimer Dilinoleate LUSPLAN DD-DA7: Dimer Dilinoleyl Dimer Dilinoleate LUSPLAN SR-DM4: Dimer dilinoleyl dimer dilinoleate, Caprylic / Capric triglyceride Neosolue-Aqulio: Bisethoxydiglycol Cyclohexanedicarboxylic Acid 〇Neosolue-AquaS: (Eicosanedioic acid / Tetradecanedioic acid) Polyglyceryl-10, Glycerin Phytocompo HS: Glycerin, Lecithin, Ethanol, Cetearyl Alcohol, Tocopherol, Citric Acid 〇Phytocompo-PP: Hydrogenated lecithin, phytosterols 〇Phytocompo-C: Hydrogenated lecithin, phytosterols, ceramide NG, ceramide NP, ceramide AP 〇Phytopresome: Hydrogenated lecithin, phytosterols Presome Cera-236: Hydrogenated lecithin, cholesterol, ceramide NG, ceramide NP, ceramide AP Phytopresome Plus: Hydrogenated lecithin, phytosterols, phytosphingosine, BG, lactic acid, water Phospholipid PCSH70: Hydrogenated lecithin Plandool-H: Dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl) Plandool-G: Dimer dilinoleyl dimer dilinoleate bis(behenyl / isostearyl / phytosteryl) Plandool-DP: Bis-diglyceryl polyacyladipate-2 Plandool-ISS: Phytosteryl isostearate Plandool-SUN: Phytosteryl sunflower seed oil fatty acids Plandool-MAS: Macadamia nut oil fatty acid phytosteryl Plandool-LG1: Lauroyl glutamate di(phytosteryl / octyldodecyl / behenyl) Plandool-LG2: Lauroyl glutamate di(phytosteryl / octyldodecyl) Plandool-LG3: Lauroyl glutamate di(phytosteryl / octyldodecyl / behenyl) Plandool-LG4: Lauroyl glutamate di(phytosteryl / octyldodecyl / behenyl) PrimeLipid ALPA: Lysophosphatidic acid, lysolecithin, glycerin, water, aluminum hydroxide PrimeLipid PI: Hydrogenated lecithin, lecithin, phytosterols, tocopherols Tremoist-TP: Tremella fuciformis polysaccharide

Claims

1. A cosmetic or topical skin preparation containing the following ingredients (A) and (B). (A) One or more water-soluble whitening agents selected from tranexamic acid or its derivatives, ascorbic acid or its derivatives, hydroquinone or its derivatives, nicotinic acid or its derivatives, and salicylic acid or its derivatives. (B) Tocopherol nicotinate

2. The cosmetic or topical skin preparation according to claim 1, wherein component (A) is one or more selected from tranexamic acid, 3-O-ethyl ascorbic acid, and arbutin.

3. The cosmetic or topical skin preparation according to claim 1, wherein component (A) is tranexamic acid.

4. A cosmetic or topical skin preparation according to any one of claims 1 to 3, wherein the content of component (A) is 0.1 to 10% by mass, and the content of component (B) is 0.01 to 2% by mass.

Images