Chromatogram data processing device

Abstract

This reduces the workload for operators in setting parameters for chromatogram waveform processing. [Solution] A chromatogram data processing device comprising: a chromatogram acquisition unit 24 for acquiring a chromatogram; a parameter specification reception unit 22 for accepting operations to specify multiple values ​​for predetermined waveform processing parameters; a waveform processing execution unit 24 for executing waveform processing on the chromatogram by applying the multiple values ​​of the predetermined waveform processing parameters received by the parameter specification reception unit; and a display control unit 25 for displaying on a display device 32 a first waveform processing result acquired by waveform processing applying one of the multiple values ​​of the predetermined waveform processing parameters, and a second waveform processing result acquired by waveform processing applying another of the multiple values.

Description

Technical Field

[0005] , ,

[0001] The present invention relates to a chromatogram data processing device.

Background Art

[0002] In a chromatograph such as a gas chromatograph or a liquid chromatograph, sample components separated by a column over time are detected by a detector such as an ultraviolet-visible light spectrometer, and based on this detection signal, a chromatogram showing the temporal change in signal intensity is created. In order to perform qualitative or quantitative analysis of various components contained in the sample, it is necessary to identify the peaks contained in the obtained chromatogram. Such peak identification is generally performed by an automatic detection algorithm. The process of identifying each peak in the chromatogram by such an automatic detection algorithm is hereinafter referred to as waveform processing.

[0003] In order to obtain appropriate waveform processing results by an automatic detection algorithm, it is necessary to appropriately set various parameters related to waveform processing (hereinafter referred to as waveform processing parameters). As waveform processing parameters, for example, parameters such as "Width" or "Slope" are used. "Width" is the minimum value of the full width at half maximum determined to be a peak in waveform processing. "Slope" is the threshold of the slope of the waveform determined to be the rising position or the falling position of the peak in waveform processing.

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] Conventionally, when performing waveform processing on a chromatogram obtained from analyzing a sample, the analyst (operator) first specifies appropriate values ​​for various waveform processing parameters on a predetermined settings screen, and then runs the waveform processing on the chromatogram using an automatic detection algorithm. Then, they visually check the obtained waveform processing results, and if necessary, open the settings screen again to change the values ​​of the various waveform processing parameters and run the waveform processing again. This process must be repeated until an appropriate waveform processing result is obtained. Such a process is cumbersome and places a heavy burden on the operator.

[0006] This invention has been made in view of the above points, and its purpose is to reduce the workload of operators regarding the setting of waveform processing parameters. [Means for solving the problem]

[0007] The chromatogram data processing apparatus according to the present invention, which was developed to solve the above problems, A chromatogram acquisition unit that acquires chromatograms, A parameter specification receiving unit that accepts operations to specify multiple values ​​for predetermined waveform processing parameters, A waveform processing execution unit executes waveform processing on the chromatogram by applying a plurality of predetermined waveform processing parameter values ​​received by the parameter specification reception unit, A display control unit that displays on a display device a first waveform processing result obtained by waveform processing applying one of the multiple values ​​of the predetermined waveform processing parameters, and a second waveform processing result obtained by waveform processing applying another of the multiple values. It possesses the following characteristics. [Effects of the Invention]

[0008] According to the chromatogram data processing device of the present invention having the above configuration, by performing a single parameter specification operation (i.e., an operation to specify multiple values ​​for the predetermined waveform processing parameters) on the parameter specification reception unit, the operator can perform waveform processing on the chromatogram with mutually different parameter values ​​and obtain multiple waveform processing results, which can then be displayed on the display device. This reduces the workload of the operator regarding the setting of waveform processing parameters. [Brief explanation of the drawing]

[0009] [Figure 1] A diagram showing the main components of a chromatograph system according to one embodiment of the present invention. [Figure 2] A conceptual diagram illustrating the separation of chromatogram peaks by vertical partitioning. [Figure 3] A conceptual diagram illustrating the separation of chromatogram peaks through complete separation. [Figure 4] A flowchart showing an example of the operation of the data processing device included in the embodiment. [Figure 5] A diagram showing an example of a parameter setting screen. [Figure 6] A diagram showing another example of the parameter setting screen. [Figure 7] A diagram showing an example of how waveform processing results are displayed. [Figure 8] A flowchart illustrating another example of how a data processing device works. [Figure 9] A diagram showing another example of how waveform processing results can be displayed. [Modes for carrying out the invention]

[0010] The embodiments for carrying out the present invention will be described below with reference to the drawings. Figure 1 is a diagram showing the main components of a chromatograph system according to this embodiment. As shown in the figure, this chromatograph system comprises a chromatograph unit 10 and a data processing device 20. This data processing device 20 corresponds to the chromatogram data processing device in the present invention. The chromatograph unit 10 may be a liquid chromatograph or a gas chromatograph, but in the following description, it will be described as a liquid chromatograph.

[0011] The chromatograph unit 10 comprises a liquid delivery pump 11, a sample introduction unit 12, a column 13, and a detector 14. The liquid delivery pump 11 delivers the mobile phase contained in a mobile phase container (not shown) to the column 13, and the sample introduction unit 12 injects a predetermined amount of sample into the mobile phase flow path from the liquid delivery pump 11 to the column 13. The components in the sample (sample components) introduced into the column 13 by the flow of the mobile phase are separated from each other as they pass through the column 13 and sequentially elute from the outlet end of the column 13. The outlet end of the column 13 is connected to the detector 14, and each sample component eluted from the column 13 is detected by this detector 14. The detector 14 can be, for example, an optical detector using a photodiode array (PDA) or a mass spectrometer, but is not limited to these.

[0012] The signal output from the detector 14 is converted into digital data by an A / D converter (not shown) and then input to the data processing device 20. The data processing device 20 performs predetermined processing on this digital data and is essentially a computer (e.g., a personal computer) equipped with a CPU, memory, and a large-capacity storage device (e.g., HDD or SSD). The computer is connected to an input unit 31 (corresponding to the transition stop operation reception unit and waveform processing result selection reception unit in the present invention) which includes a pointing device such as a mouse or a keyboard, and a display unit 32 which includes a liquid crystal display or an organic EL display. The data processing device 20 includes, as functional blocks, a chromatogram generation unit 21, a parameter specification reception unit 22, a parameter value combination generation unit 23, a waveform processing unit 24 (corresponding to the chromatogram acquisition unit and waveform processing execution unit in the present invention), and a display control unit 25. These are functional means realized by executing a predetermined program installed on the computer using the computer's CPU. Furthermore, the data processing device 20 includes a chromatogram storage unit 26, a parameter value combination storage unit 27, a final result storage unit 28 (corresponding to the waveform processing result storage unit in the present invention), and a parameter storage unit 29 (corresponding to the waveform processing parameter storage unit in the present invention). These functions are realized by a large-capacity storage device provided in the computer.

[0013] The digital data input to the data processing device 20 is sent to the chromatogram generation unit 21. Based on the digital data, the chromatogram generation unit 21 generates a chromatogram, which is a waveform showing the time change of signal intensity, and stores it in the chromatogram storage unit 26.

[0014] The waveform processing unit 24 identifies peaks on the chromatogram based on predetermined parameters (waveform processing parameters). Examples of these parameters include "Slope," "Width," and "peak separation method."

[0015] "Slope" is the threshold of the slope (intensity / time) of the waveform for detecting the peak start point and the peak end point. For example, when the Slope value is 100 μV / sec, in the direction from left to right of the horizontal axis (time axis) of the chromatogram, the point when the slope of the waveform first exceeds 100 μV / sec is recognized as the peak start point. After that, around the peak top, the slope of the waveform becomes a negative value and further drops below -100 μV / sec. And the point when the slope of the waveform becomes larger than -100 μV / sec again is recognized as the peak end point. Therefore, the positions of the detected peak start point and peak end point will change depending on the value of "Slope".

[0016] "Width" is the minimum value of the full width at half maximum of the peak to be detected. For example, when the Width value is 5 sec, among the regions from the peak start point to the peak top and then to the peak end point on the chromatogram, the region with a full width at half maximum of 5 sec or more is judged as a peak, and the region with a full width at half maximum of less than 5 sec is judged as noise. Therefore, by setting a larger value for "Width", it is possible to prevent noise from being detected as a peak. On the other hand, when the value of "Width" increases, adjacent peaks that partially overlap are more likely to be detected as one peak.

[0017] "Peak separation method" is a type of method for dividing a peak group composed of adjacent peaks that partially overlap into a plurality of peaks, and there are vertical division or complete separation (baseline separation), etc. Vertical division, as shown in FIG. 2, is a method of separating adjacent peaks by a vertical line (broken line in the figure) dropped from a valley between two adjacent peaks (the point where the intensity is minimized in the region sandwiched between the peak tops of both peaks) to a single horizontal baseline (dotted line in the figure) set for the peak group. In this method, the area of each peak is the area of the region surrounded by the waveform from the peak start point through the peak top to the peak end point, the baseline, and the vertical line (the shaded region in FIG. 2). On the other hand, complete separation, as shown in FIG. 3, is a method of separating adjacent peaks by setting a baseline (dotted line in the figure) connecting the start point and the end point for each peak included in the peak group. In this method, the area of each peak is the area of the region surrounded by the waveform from the peak start point through the peak top to the peak end point and the baseline (the shaded region in FIG. 3). Therefore, by changing the peak separation method, the size of the region recognized as the area of each peak changes, and as a result, the quantitative value of the component corresponding to each peak changes.

[0018] Hereinafter, the characteristic operations of the data processing apparatus 20 according to the present embodiment will be described while referring to the flowchart of FIG. 4. Here, it is assumed that data of one or more chromatograms generated by the chromatogram generation unit 21 in advance in accordance with the analysis of the sample by the chromatograph unit 10 is stored in the chromatogram storage unit 26.

[0019] First, the operator performs a predetermined operation using the input unit 31 to display a chromatogram selection screen (not shown) on the display unit 32 for selecting a chromatogram to be processed from among the one or more chromatograms stored in the chromatogram storage unit 26 (hereinafter referred to as the target chromatogram). Once the operator selects an appropriate chromatogram on the screen (step 51), the parameter specification reception unit 22 then displays a parameter setting screen on the display unit 32 for the operator to set the waveform processing parameters.

[0020] Figure 5 shows an example of the parameter setting screen. This screen includes a Width value specification area 110, a Slope value specification area 120, and a peak separation method specification area 130.

[0021] The Width value specification area 110 is provided with radio buttons 111 and 112 for selecting whether to specify a single Width value or multiple Width values. When specifying a single Width value, the operator selects the upper radio button 111 and enters a single appropriate numerical value in the Width value input field 113 to the right of the radio button 111. On the other hand, when specifying multiple Width values, the operator selects the lower radio button 112 and enters the upper and lower limits of the Width value in the Width value range input field 114 to its right, and then enters a data point setting value in the adjacent Width value point input field 115, which indicates how many Width values ​​to set within the numerical range defined by the upper and lower limits. Instead of a data point setting value, a step value, which is the width of the value to be divided, may be entered. For example, if you set the upper limit of Width to 1.0 and the lower limit to 0.5, and set the number of data points to 6, the combination of values ​​1.0, 0.9, 0.8, 0.7, 0.6, and 0.5 will be set. On the other hand, if you set the same upper and lower limits as above, and set the step value to 0.1, the same combination of values ​​will be set.

[0022] Similarly, in the Slope value specification area 120, radio buttons 121 and 122 are provided for selecting whether to specify only one Slope value or multiple Slope values. When specifying only one Slope value, the operator selects the upper radio button 121 and enters a single appropriate numerical value in the Slope value input field 123 to the right of the radio button 121. On the other hand, when specifying multiple Slope values, the operator selects the lower radio button 122 and enters the upper and lower limits of the Slope value in the Slope value range input field 124 to its right, and then enters the number of Slope value points to set within the numerical range defined by the upper and lower limits in the adjacent Slope value point input field 125.

[0023] The peak separation method specification area 130 is provided with a checkbox 131 for selecting vertical separation as the peak separation method and a checkbox 132 for selecting complete separation. The operator can check either one or both of these checkboxes 131 and 132.

[0024] In this example, when specifying multiple Width or Slope values, the operator is required to specify the range of the Width or Slope values ​​and how many points (or what step values) to set within that range. Alternatively, the operator may be required to specify the initial value of the Width or Slope value and how many points to set with what step values ​​starting from that initial value. An example of a parameter setting screen in such a case is shown in Figure 6.

[0025] After the operator sets the parameter values ​​(i.e., Width value, Slope value, and type of peak separation method) on a parameter setting screen as shown in Figure 5 or Figure 6 (step 52), and then performs a predetermined operation on the input unit 31, the parameter value combination generation unit 23 generates combinations of parameter values ​​derived from the contents entered on the parameter setting screen (step 53). For example, in the example shown in Figure 5, the Width value is set to 1 point (5 sec), the Slope value to 5 points (100 μV / sec, 150 μV / sec, 200 μV / sec, 250 μV / sec, and 300 μV / sec), and two types of peak separation methods (vertical separation and complete separation) are specified. As a result, 1 × 5 × 2 = 10 combinations are generated as combinations of these Width values, Slope values, and types of peak separation methods. Furthermore, in the example shown in Figure 6, one Width value (5 sec), four Slope values ​​(100 μV / sec, 200 μV / sec, 300 μV / sec, and 400 μV / sec), and one type of peak separation method (vertical separation only) are specified. As a result, 1 × 4 × 1 = 4 possible combinations of these Width values, Slope values, and peak separation methods are generated.

[0026] The combination of parameter values ​​generated as described above is stored in the parameter value combination storage unit 27.

[0027] Next, the waveform processing unit 24 sets the counter value n related to waveform processing to 1 (step 54). Then, the waveform processing unit 24 reads the target chromatogram specified in step 51 from the chromatogram storage unit 26, and reads the first combination of parameter values ​​(hereinafter sometimes simply referred to as a combination) stored in the parameter value combination storage unit 27, and performs waveform processing on the target chromatogram using the first combination (step 55). The resulting waveform processing result is displayed on the display unit 32 under the control of the display control unit 25 (step 56).

[0028] After a predetermined time (e.g., several seconds to a dozen or so seconds) has elapsed (when Step 58 becomes Yes), the waveform processing unit 24 determines whether waveform processing for all combinations generated in Step 53 has been completed (Step 59). If it is determined that the processing is not completed, the counter value n is incremented (Step 60), waveform processing for the second combination is executed (Step 55), and the result is displayed on the display unit 32 by the display control unit 25 (Step 56). As a result, the display unit 32 transitions from the state in which the waveform processing result for the first combination is displayed (hereinafter referred to as the first state) to the state in which the waveform processing result for the second combination is displayed (hereinafter referred to as the second state).

[0029] Thereafter, Steps 55 to 60 are repeatedly executed (Step 57 will be described later) until it is determined in Step 59 that waveform processing for all combinations has been completed. FIG. 7 shows an example of the display content on the display unit 32 at this time. In the upper part of the figure, a state in which the waveform processing result for the k-th combination (k is an integer and 1 ≦ k < x) among the x combinations (x is an integer of 2 or more) stored in the parameter value combination storage unit 27 is displayed is shown. The lower part of the figure represents a state in which the waveform processing result for the (k + 1)-th combination is displayed due to subsequent screen transitions. Also, in the example of the figure, as the waveform processing result, a line indicating the baseline or a line indicating the boundary of adjacent peaks or both, and a shading indicating the peak region are superimposed and displayed on the waveform of the target chromatogram. Note that the upper part of FIG. 7 shows the result of separating adjacent peaks by vertical separation, and the lower part of FIG. 7 shows the result of separating adjacent peaks by complete separation.

[0030] The operator visually observes the sequentially transitioning display content on the display unit 32 and inputs an instruction to stop the transition of the display content via the input unit 31 when it is determined that an appropriate waveform processing result is displayed. This instruction is hereinafter referred to as a display transition stop instruction.

[0031] When the display transition stop instruction is input (i.e., when it becomes Yes in step 57), the display control unit 25 stops the transition of the display content on the display unit 32, and stores the waveform processing result being displayed at that time in the final result storage unit 28 as the final waveform processing result for the target chromatogram (step 61). Further, when the final waveform processing result is obtained, the waveform processing unit 24 reads out the combination of parameter values from the parameter value combination storage unit 27, and stores the combination in the parameter storage unit 29 as the combination of parameter values to be applied to future waveform processing (step 62), and ends a series of processes.

[0032] Therefore, for example, when the display transition stop instruction is input while the waveform processing result by the m-th combination (m is an integer and 1 ≦ m < x) among the x combinations (x is an integer of 2 or more) stored in the parameter value combination storage unit 27 is being displayed, the waveform processing by the combinations after the (m + 1)-th combination and the display of the result of the waveform processing are not executed.

[0033] Note that when it is determined that the waveform processing by all combinations (i.e., the x combinations) is completed without the display transition stop instruction being input from the operator (i.e., when it becomes Yes in step 59), a series of processes end without steps 61 and 62 being executed.

[0034] As described above, in the data processing device according to this embodiment, the operator performs a single setting operation (i.e., a setting operation on the waveform processing parameter setting screen), and the results of waveform processing with various parameter values ​​are sequentially displayed on the display unit 32. When an appropriate waveform processing result is displayed, the operator inputs a display transition stop instruction, and the waveform processing result is stored as the final waveform processing result, and the combination of parameter values ​​applied at that time is stored as the combination of parameter values ​​to be applied thereafter. Therefore, as in the conventional method, the operator does not need to repeatedly input parameter values ​​into a predetermined setting screen and visually confirm the waveform processing results obtained by applying those parameter values ​​in order to search for the optimal parameter values, thus reducing the workload of the operator in determining parameter values.

[0035] In the above description, the combination of parameter values ​​corresponding to the waveform processing result displayed on the display unit 32 at the time the operator inputs the display transition stop instruction (i.e., the combination of parameter values ​​when the waveform processing result was obtained) is stored as the combination of parameter values ​​to be applied thereafter. However, it is also possible to allow the parameter values ​​to be narrowed down after the input of the display transition stop instruction.

[0036] Specifically, for example, when the display control unit 25 receives a command from the operator to stop the display transition, it displays a screen on the display unit 32 that allows the operator to choose whether to determine the waveform processing result currently displayed as the final waveform processing result for the target chromatogram, or to narrow down the parameter values. If the operator chooses to narrow down the parameter values ​​on that screen, the display control unit 25 displays a screen on the display unit 32 that is similar to the parameter setting screen shown in Figure 5 or Figure 6.

[0037] On the screen displayed at this time (hereinafter referred to as the parameter reset screen), the operator may be allowed to freely set the values ​​of each parameter. Alternatively, parameters for which three or more values ​​were specified in step 52 may be allowed to be specified within a predetermined range that includes the values ​​that were applied when the display transition stop instruction was input (hereinafter referred to as the temporary parameter values), and changes to other parameters may not be accepted. In this case, the predetermined range shall not include any values ​​other than the temporary parameter values ​​among the three or more values. For example, if, in step 52, each parameter value is specified as shown in the example in Figure 5, and in step 56, the waveform processing result with a Width value of 5 sec, a Slope value of 200 μV / sec, and vertical splitting applied as the peak separation method is displayed, and a display transition stop instruction (step 57) is input, the parameter reset screen may not accept input for the Width value and peak separation method, and the Slope value may be allowed to be set to multiple values ​​in a range greater than 150 μV / sec and less than 250 μV / sec.

[0038] Next, in the same manner as in step 53 described above, combinations of parameter values ​​are generated from the information entered in the parameter reset screen. For example, in the example above, multiple combinations of parameter values ​​are generated by fixing the Width value to 5 sec and the peak separation method to vertical separation, and changing only the Slope value. After that, the same processing as in steps 54 to 62 is performed.

[0039] Although specific examples of embodiments for carrying out the present invention have been described above, the present invention is not limited to those described above, and modifications are permitted as appropriate within the scope of the spirit of the invention. For example, in the above embodiment, waveform processing (step 55) applying one of the combinations of parameter values ​​generated in step 53 and displaying the waveform processing result (step 56) are repeatedly performed at predetermined time intervals. However, instead, after performing waveform processing applying each of the combinations of parameter values ​​generated in step 53, the results of each waveform processing may be displayed side by side on the screen of the display unit 32. The operation of the data processing device 20 in that case will be described below with reference to the flowchart in Figure 8.

[0040] First, as in steps 51 to 53 described above, the target chromatogram is specified (step 71), waveform processing parameters are set (step 72), and combinations of parameter values ​​are generated (step 73). Then, the waveform processing unit 24 reads all combinations of parameter values ​​stored in the parameter value combination storage unit 27 (i.e., the x combinations) and applies each to the target parameter to generate x waveform processing results (step 74). Subsequently, the display control unit 25 displays the x waveform processing results in a row on the screen of the display unit 32 (step 75). An example of the display screen at this time (hereinafter referred to as the waveform processing result display screen) is shown in Figure 9. In the example shown in the figure, multiple waveform processing results 201 are displayed in a single vertical column on the waveform processing result display screen, and the operator can view all waveform processing results 201 by scrolling the screen up and down via the input unit 31. The x waveform processing results may be displayed in a list on the waveform processing result display screen, or the waveform processing result display screen may consist of multiple pages, with the x waveform processing results displayed on multiple pages. The operator visually checks each waveform processing result 201 displayed on the waveform processing result display screen and selects an appropriate one by clicking or other means (step 76). As a result, the selected waveform processing result 201 is stored in the final result storage unit 28 as the final waveform processing result for the target chromatogram (step 77), and the combination of parameter values ​​corresponding to the waveform processing result is stored in the parameter storage unit 29 as a combination of parameter values ​​to be applied to subsequent waveform processing (step 78). In this case as well, it may be possible to narrow down the parameter values ​​as described above.

[0041] Also, after generating the x waveform processing results (i.e., after executing step 74 above), the x waveform processing results may be sequentially displayed on the display unit 32 one by one at a predetermined time interval. In that case, when a display transition stop instruction is input from the operator, the transition of the display content is stopped, and the waveform processing result being displayed at that time is stored in the final result storage unit 28 as the final waveform processing result, and the combination of parameter values corresponding to the waveform processing result is stored in the parameter storage unit 29 as the combination of parameter values to be applied to future waveform processing. In this case, for example, when a display transition stop instruction is input while the waveform processing result by the m-th combination (m is an integer and 1 ≤ m < x) among the x combinations is being displayed, the display of the waveform processing results by combinations after the (m + 1)-th combination will not be executed.

[0042] In the above-described embodiment, in the parameter setting screen (and the parameter value re-setting screen), the Slope value, the Width value, and the type of peak separation method are specified as parameter values. However, in addition to or instead of these, other waveform processing parameters, for example, the minimum peak area (the minimum value of the area of the region determined to be a peak), the minimum peak height (the minimum value of the height of the peak top determined to be a peak), or the drift value (the upper limit value of the allowable range of the slope of the baseline in complete separation), etc. may be set, and for some or all of them, a plurality of values may be set.

[0043] In the above-described embodiment, the chromatogram generation unit 21, the chromatogram storage unit 26, and the waveform processing unit 24 are provided in the computer constituting the data processing device 20. However, the data processing device according to the present invention may not have the chromatogram generation unit 21 and the chromatogram storage unit 26 and may have only the waveform processing unit 24. In that case, the waveform processing unit 24 acquires a chromatogram generated by a computer different from the computer constituting the data processing device 20 according to the present invention from the different computer via a network such as a LAN or the Internet, and performs waveform processing on the chromatogram.

[0044] [Aspect] It will be obvious to those skilled in the art that the exemplary embodiments described above are specific examples of the following embodiments.

[0045] (Section 1) A chromatogram data processing device according to one aspect of the present invention is: A chromatogram acquisition unit that acquires chromatograms, A parameter specification receiving unit that accepts operations to specify multiple values ​​for predetermined waveform processing parameters, A waveform processing execution unit executes waveform processing on the chromatogram by applying a plurality of predetermined waveform processing parameter values ​​received by the parameter specification reception unit, A display control unit that displays on a display device a first waveform processing result obtained by waveform processing applying one of the multiple values ​​of the predetermined waveform processing parameters, and a second waveform processing result obtained by waveform processing applying another of the multiple values. It possesses the following characteristics.

[0046] (Paragraph 2) The chromatogram data processing device relating to Paragraph 2 is a chromatogram data processing device relating to Paragraph 1, The display control unit transitions the display device from a first state, in which the first waveform processing result is displayed, to a second state, in which the second waveform processing result is displayed. The display control unit includes a transition stop operation receiving unit that receives an operation to stop the transition of the display device from the first state to the second state, It further possesses the following:

[0047] (Paragraph 3) The chromatogram data processing device relating to Paragraph 3 is a chromatogram data processing device relating to Paragraph 1 or Paragraph 2, The parameter specification receiving unit receives specifications for the upper limit, lower limit, and data point setting value representing the number of data points to be set for the predetermined waveform processing parameters.

[0048] (Paragraph 4) The chromatogram data processing device relating to Paragraph 4 is a chromatogram data processing device relating to Paragraph 1 or Paragraph 2, The parameter specification receiving unit accepts the specification of the upper limit, lower limit, and step value representing the interval of change of the predetermined waveform processing parameter.

[0049] (Paragraph 5) The chromatogram data processing device relating to Paragraph 5 is a chromatogram data processing device relating to any one of Paragraphs 1 to 4, Furthermore, A waveform processing result selection receiving unit accepts an operation to select one of the waveform processing results obtained by the waveform processing execution unit, A waveform processing result storage unit that stores the waveform processing result selected by the waveform processing result receiving unit, It possesses the following characteristics.

[0050] (Paragraph 6) The chromatogram data processing device relating to Paragraph 6 is a chromatogram data processing device relating to any one of Paragraphs 1 to 4, Furthermore, A waveform processing result selection receiving unit accepts an operation to select one of the waveform processing results obtained by the waveform processing execution unit, A waveform processing parameter storage unit stores, among a plurality of predetermined waveform processing parameter values, the value selected by the waveform processing result selection receiving unit and applied to the waveform processing for which the waveform processing result was obtained, as the value of the waveform processing parameter to be applied to the waveform processing of the chromatogram acquired thereafter. It possesses the following characteristics. [Explanation of Symbols]

[0051] 10…Chromatography section 11…Liquid transfer pump 12... Sample introduction section 13... Columns 14… Detector 20...Data Processing Unit 21...Chromatogram generation section 22...Parameter specification reception unit 23...Parameter value combination generation unit 24...Waveform Processing Unit 25...Display Control Unit 26...Chromatogram storage unit 27... Parameter value combination storage unit 28...Final result storage section 29...Parameter storage unit 31...Input section 32…Display section

Claims

1. A chromatogram acquisition unit that acquires chromatograms, A parameter specification receiving unit that accepts operations to specify multiple values ​​for predetermined waveform processing parameters, A waveform processing execution unit executes waveform processing on the chromatogram by applying a plurality of predetermined waveform processing parameter values ​​received by the parameter specification reception unit, A display control unit that displays on a display device a first waveform processing result obtained by waveform processing applying one of the multiple values ​​of the predetermined waveform processing parameters, and a second waveform processing result obtained by waveform processing applying another of the multiple values. A chromatogram data processing device having

2. The display control unit transitions the display device from a first state, in which the first waveform processing result is displayed, to a second state, in which the second waveform processing result is displayed. The display control unit includes a transition stop operation receiving unit that receives an operation to stop the transition of the display device from the first state to the second state, It further has, The chromatogram data processing apparatus according to claim 1.

3. The parameter specification receiving unit receives specifications for the upper limit, lower limit, and data point setting value representing the number of data points to be set for the predetermined waveform processing parameters. The chromatogram data processing apparatus according to claim 1.

4. The parameter specification receiving unit accepts the specification of the upper limit, lower limit, and step value representing the interval of change of the predetermined waveform processing parameter. The chromatogram data processing apparatus according to claim 1.

5. Furthermore, A waveform processing result selection receiving unit accepts an operation to select one of the waveform processing results obtained by the waveform processing execution unit, A waveform processing result storage unit that stores the waveform processing result selected by the waveform processing result receiving unit, A chromatogram data processing apparatus according to claim 1, having the following features.

6. Furthermore, A waveform processing result selection receiving unit accepts an operation to select one of the waveform processing results obtained by the waveform processing execution unit, A waveform processing parameter storage unit stores, among a plurality of predetermined waveform processing parameter values, the value selected by the waveform processing result selection receiving unit and applied to the waveform processing for which the waveform processing result was obtained, as the value of the waveform processing parameter to be applied to the waveform processing of the chromatogram acquired thereafter. A chromatogram data processing apparatus according to claim 1, having the following features.

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