Stabilization of thiopyridinone compounds and compositions containing thiopyridinone compounds

Abstract

In particular, to provide a composition containing a thiopyridinone compound in which the time-dependent stability of the thiopyridinone compound is enhanced when the composition is maintained at high temperatures for a relatively long period of time. [Solution] A composition comprising (a) at least one thiopyridinone compound and (b) at least one compound selected from ergothioneine and its derivatives.

Description

[Technical Field]

[0001] This invention relates to the stabilization of thiopyridinone compounds in compositions containing thiopyridinone compounds. [Background technology]

[0002] At various stages of life, some people notice darker and / or more colored spots on their skin, more specifically on the appearance of their face and hands, giving their skin an uneven appearance. These spots are caused in particular by high concentrations of melanin in keratinocytes located on the surface of the skin.

[0003] For the purpose of treating hyperpigmentation stains, the use of a highly effective, harmless, topical depigmenting substance is most specifically desired.

[0004] For example, arbutin, niacinamide, and kojic acid are well known as skin depigmenting agents.

[0005] On the other hand, WO2017 / 102349 discloses novel decolorizing or whitening agents, namely thiopyridinone compounds. Thiopyridinone compounds can exhibit a strong decolorizing or whitening effect by reducing melanin production. [Prior art documents] [Patent Documents]

[0006] [Patent Document 1] WO2017 / 102349 [Patent Document 2] EP-A-3390363 [Patent Document 3] WO2017 / 102349 [Non-patent literature]

[0007] [Non-Patent Document 1] CTFA International Cosmetic Ingredient Dictionary & Handbook, 15th Edition, 2014. [Overview of the project] [Problems that the invention aims to solve]

[0008] However, it has been found that thiopyridinone compounds tend to become unstable over time, especially when compositions containing thiopyridinone compounds are maintained at high temperatures for relatively long periods of time.

[0009] Therefore, an object of the present invention is to provide a composition containing a thiopyridinone compound in which the time-dependent stability of the thiopyridinone compound is enhanced, particularly when the composition is maintained at high temperatures for a relatively long period of time. [Means for solving the problem]

[0010] The purpose of the above is, (a) At least one first compound selected from the compounds of formula (I), tautomers of formula (I'), salts thereof, solvates such as hydrates thereof, optical isomers thereof, racemates thereof, and mixtures thereof:

[0011] [ka]

[0012] (In the formula, R1 is a) Hydrogen atoms, and b) i)-O-R3 and ii)-S-R3 A saturated linear C1-C molecule, optionally substituted with one or more groups, which may be identical or different, selected from the above. 10 Or branched C3~C 10 alkyl group The base selected from is shown, R2 is a) a hydrogen atom, and b) i) -O-R3, ii) -S-R3, iii) -C(O)-O-R3, and iv) a C5-C 12 aryl group optionally substituted with one or more hydroxyls and / or one or more C1-C8 alkoxy groups selected from one or more groups, which may be the same or different, of a saturated linear C1-C 12 or branched C3-C 12 or cyclic C3-C8 hydrocarbonated group, and c) a C5-C 12 aryl group optionally substituted with one or more hydroxyls and / or one or more C1-C8 alkoxy groups selected from the group, wherein, R3 is a) a hydrogen atom, and b) a saturated linear C1-C 10 or branched C3-C 10 alkyl group selected from the group) and (b) at least one second compound selected from ergothioneine and its derivatives can be achieved by a composition, preferably a cosmetic composition, more preferably a skin cosmetic composition.

[0013] The following may be preferred: R1 in formulas (I) and (I') represents a hydrogen atom, or or R1 in formulas (I) and (I') is a linear (C1-C 10 ) alkyl group or a branched (C3-C 10) represents an alkyl group, particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably ethyl, and in particular the alkyl group of R1 is not substituted.

[0014] The following may be preferable: In equations (I) and (I'), R2 represents a hydrogen atom, or or In equations (I) and (I'), R2 is linear (C1~C 10 ) alkyl group or branched (C3~C 10 ) an alkyl group, particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably a methyl or ethyl group, and the alkyl group of R2 is not substituted.

[0015] The following may be preferable: In equations (I) and (I'), R2 is linear (C1~C 10 ) Alkyl or branched (C3~C 10 ) an alkyl group, particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably methyl or ethyl, wherein the alkyl group is substituted with one or more groups selected from i), ii), iii) and iv) as defined above, preferably the alkyl group is substituted with one or two groups selected from i), ii) and iii), more preferably one or two groups selected from i) and iii), and even better, one group iii) as a carboxyl group.

[0016] The following may be preferable: In formulas (I) and (I'), R2 represents a (C3-C8) cycloalkyl group, preferably a (C5-C7) cycloalkyl group, such as cyclohexyl. or In formulas (I) and (I'), R2 is optionally substituted with one or more hydroxyl and / or one or more C1-C8 alkoxy groups, C5-C8 12 This represents an aryl group, preferably an unsubstituted phenyl group.

[0017] The following may be preferable: In equations (I) and (I'), R3 represents a hydrogen atom, or or In equations (I) and (I'), R3 is a saturated linear C1-C 10 Alternatively, branched C3~C 10 The alkyl group represents an alkyl group, particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably a (C1-C4) alkyl group, such as a methyl group.

[0018] The following may be preferable: R1 in equations (I) and (I') is a) Hydrogen atoms, and b) i)-O-R3 and ii)-S-R3, A saturated linear C1-C6 or branched C3-C6 alkyl group, which is optionally substituted with one or more groups, which may be the same or different, and is preferably optionally substituted with one or more groups i). Represents a base selected from, R2 in equations (I) and (I') is a) A hydrogen atom and, b) i)-O-R3, ii)-S-R3, iii)-C(O)-O-R3, and iv) One or more hydroxyl and / or one or more C1-C4 alkoxy groups, for example, methoxy, which are optionally substituted with phenyl groups. A saturated linear C1-C1 is optionally substituted with one or more groups selected from i) and iii), which may be the same or different, preferably one or more groups selected from i) and iii), preferably substituted with iii) such as carboxyl. 10 Or branched C3~C 10 Or cyclic C3-C8, for example, C5-C6 hydrocarbon groups Represents a base selected from, R3 in equations (I) and (I') is a) Hydrogen atoms, and b) Saturated linear C1-C6 or branched C3-C6 alkyl groups Represents a base selected from, In preference, the compounds of formula (I) and their tautomers (I'), their salts, solvates such as their hydrates, their optical isomers, their racemates, and mixtures thereof have the following meanings: R1 in equations (I) and (I') is a) Hydrogen atoms, and b)i) A saturated linear C1-C4 or branched C3-C4 alkyl group, optionally substituted, more preferably unsubstituted, with one or more groups selected from -OR3, which may be the same or different. Represents a base selected from, R2 in equations (I) and (I') is a) A hydrogen atom and, b) i)-O-R3, iii)-C(O)-O-R3, and iv) C5-C4 alkoxy groups optionally substituted with one or more hydroxyl groups and / or one or more C1-C4 alkoxy groups. 12 aryl group A saturated linear C1-C molecule, optionally substituted with one or more groups, which may be identical or different, selected from the above. 10 Or branched C3~C 10 Or cyclic C3-C8, for example, C5-C6 hydrocarbon groups Represents a base selected from, R3 in equations (I) and (I') is a) Hydrogen atoms, and b) Saturated linear C1-C4 or branched C3-C4 alkyl groups, such as methyl or ethyl alkyl groups. It represents the base selected from.

[0019] (a) The first compound may be selected from the following compounds 1 to 24, their tautomers, their salts, solvates such as their hydrates, their optical isomers, their racemates, and mixtures thereof, particularly compounds 1, 2, 4, 6, 7, 9, 11, 12, 14, 15, 16, 17, 18, 19, 20, or 21, more specifically 1, 9, 16, 18, 19, 20, or 21, preferably 18, 19, 20, or 21, and more preferably 20.

[0020] [Table 1A]

[0021] [Table 1B]

[0022] [Table 1C]

[0023] [Table 1D]

[0024] The amount of (a) the first compound in the composition according to the present invention may be 0.001% to 10% by mass, preferably 0.005% to 5% by mass, and more preferably 0.01% to 3% by mass, based on the total mass of the composition.

[0025] (b) The second compound has the following chemical formula (II):

[0026] [ka]

[0027] (In the formula, X represents the -O-R', -OM, or -NR'R'' group, R, R', and R'' are hydrogen atoms, C1-C, either simultaneously or independently. 18 Representing an alkyl group, alkenyl group, or acyl group, the alkyl group, alkenyl group, or acyl group is linear or branched and optionally substituted with at least one substituent selected from esterified hydroxyl groups, halogen atoms, carboxyl groups and their derivatives, and amine groups and their derivatives, and optionally contains at least one heteroatom such as O and S in the chain. (M represents a cation, such as a metal cation.) It can be represented by [this].

[0028] In the above chemical formula (II), the R, R', and R'' groups simultaneously or independently represent a hydrogen atom or an ethyl group, acetyl group, or acyl group. Preferably, R represents a hydrogen atom or an ethyl group, acetyl group, or acyl group, and X may represent NH2.

[0029] (b) The second compound is more preferably ergothioneine.

[0030] The amount of (b) the second compound in the composition according to the present invention may be 0.001% to 10% by mass, preferably 0.005% to 10% by mass, and more preferably 0.01% to 5% by mass, based on the total mass of the composition.

[0031] The present invention also relates to a keratin substance, preferably a cosmetic method for the skin, preferably a whitening method, Steps to apply the composition according to the present invention to a keratin substance. This also includes methods.

[0032] Another aspect of the present invention is (a) at least one first compound selected from compounds of formula (I) below, tautomers of formula (I') below, salts thereof, solvates such as hydrates thereof, optical isomers thereof, racemates thereof, and mixtures thereof:

[0033] [ka]

[0034] (In the formula, R1 is a) Hydrogen atoms, and b) i)-O-R3 and ii)-S-R3 A saturated linear C1-C molecule, optionally substituted with one or more groups, which may be identical or different, selected from the above. 10 Or branched C3~C 10 alkyl group The base selected from is shown, R2 is a) A hydrogen atom and, b) i)-O-R3, ii)-S-R3, iii)-C(O)-O-R3, and iv) C5-C8 alkoxy groups optionally substituted with one or more hydroxyl groups and / or one or more C1-C8 alkoxy groups. 12 aryl group Saturated linear C1-C1 groups are optionally substituted with one or more groups, which may be identical or different, selected from the following. 12 Or branched C3~C 12 or a cyclic C3-C8 hydrocarbon group, c) C5-C8 atoms optionally substituted with one or more hydroxyl and / or one or more C1-C8 alkoxy groups. 12 Aryl group and The base selected from is shown, During the ceremony, R3 is a) Hydrogen atoms, and b) Saturated linear C1-C 10 Or branched C3~C 10 alkyl group (Indicates the base selected from) (b) use of at least one second compound selected from ergothioneine and its derivatives in a composition containing (a) use for stabilizing the first compound. [Modes for carrying out the invention]

[0035] As a result of diligent research, the present inventors have discovered that it is possible to provide a composition containing one or more thiopyridinone compounds in which the time-dependent stability of one or more thiopyridinone compounds is enhanced, especially when the composition is maintained at high temperatures for a relatively long period of time.

[0036] Therefore, the composition according to the present invention is (a) At least one first compound selected from the following compounds of formula (I), tautomers of formula (I'), salts thereof, solvates such as hydrates thereof, optical isomers thereof, racemates thereof, and mixtures thereof (hereinafter, compounds of formula (I) or (I') will be referred to as the "first compound" or "thiopyridinone compound"):

[0037] [ka]

[0038] (In the formula, R1 is a) Hydrogen atoms, and b) i)-O-R3 and ii)-S-R3 Saturated linear C1-C1 groups are optionally substituted with one or more groups, which may be identical or different, selected from the following. 10 Or branched C3~C 10 alkyl group The base selected from is shown, R2 is a) A hydrogen atom and, b) i)-O-R3, ii)-S-R3, iii)-C(O)-O-R3, and iv) C5-C8 alkoxy groups optionally substituted with one or more hydroxyl groups and / or one or more C1-C8 alkoxy groups. 12 aryl group Saturated linear C1-C1 groups are optionally substituted with one or more groups, which may be identical or different, selected from the following. 12 Or branched C3~C 12 or a cyclic C3-C8 hydrocarbon group, c) C5-C8 atoms optionally substituted with one or more hydroxyl and / or one or more C1-C8 alkoxy groups. 12 Aryl group and The base selected from is shown, During the ceremony, R3 is a) Hydrogen atoms, and b) Saturated linear C1-C 10 Or branched C3~C 10 alkyl group (Indicates the base selected from) and (b) At least one second compound selected from ergothioneine and its derivatives Includes.

[0039] The composition according to the present invention can exhibit enhanced stability of the thiopyridinone compound (a) contained therein.

[0040] In other words, the compositions according to the present invention can enhance the stability of the (a) thiopyridinone compound therein. The term “stability” of the (a) thiopyridinone compound can be determined by the change in the amount of the (a) thiopyridinone compound in the composition according to the present invention over a certain period of time. Enhanced “stability” means that the change in the amount of the (a) thiopyridinone compound over time is further limited.

[0041] The compositions according to the present invention can exhibit enhanced stability of the (a) thiopyridinone compound even when the compositions are maintained at high temperatures such as 45°C and 55°C for relatively long periods, for example, two weeks and two months.

[0042] Therefore, the composition according to the present invention can be stored for a long period of time even under high-temperature conditions.

[0043] In addition, (a) the enhanced stability of the thiopyridinone compound can function as a decolorizing or whitening agent, and (a) the improved or enhanced bioavailability of the thiopyridinone compound. Therefore, the compositions according to the present invention can provide an enhanced or improved decolorizing or whitening effect.

[0044] The compositions and uses of the present invention will be described in detail below.

[0045] [Composition] The composition according to the present invention is (a) at least one first compound (thiopyridinone compound), and (b) At least one second compound selected from ergothioneine and its derivatives Includes.

[0046] (a) the first compound, and (b) the second compound, as well as other features of the composition according to the present invention, are described below.

[0047] (First compound) The composition according to the present invention comprises (a) at least one first compound. Two or more (a) first compounds may be used in combination. Therefore, a single type of (a) first compound or a combination of different types of (a) first compounds can be used.

[0048] (a) The first compound is selected from the compounds of formula (I), the tautomers of formula (I'), salts thereof, solvates such as hydrates thereof, optical isomers thereof, racemates thereof, and mixtures thereof:

[0049] [ka]

[0050] (In the formula, R1 is a) Hydrogen atoms, and b) i)-O-R3 and ii)-S-R3 Saturated linear C1-C1 groups are optionally substituted with one or more groups, which may be identical or different, selected from the following. 10 Or branched C3~C 10 alkyl group The base selected from is shown, R2 is a) A hydrogen atom and, b) i)-O-R3, ii)-S-R3, iii)-C(O)-O-R3, and iv) C5-C8 alkoxy groups optionally substituted with one or more hydroxyl groups and / or one or more C1-C8 alkoxy groups. 12 aryl group A saturated linear C1-C molecule, optionally substituted with one or more groups, which may be identical or different, selected from the above. 12 Or branched C3~C 12 or a cyclic C3-C8 hydrocarbon group, c) C5-C8 atoms optionally substituted with one or more hydroxyl and / or one or more C1-C8 alkoxy groups. 12 Aryl group and The base selected from is shown, During the ceremony, R3 is a) Hydrogen atoms, and b) Saturated linear C1-C 10 Or branched C3~C 10 alkyl group (Indicates the base selected from).

[0051] Unless otherwise specified, the purposes of this invention are as follows: - "Saturated linear C1~C 12 Or branched C3~C 12 "Hydroxide groups are saturated linear C1-C1 12 Or branched C3~C 12 Hydrocarbon groups, preferably linear C1-C 10 Or branched C3~C 10 A hydrocarbon group, more preferably a linear C1-C6 or branched C3-C6 hydrocarbon group, corresponds to "linear (C1-C6) 12 ) Alkyl or branched (C3~C 12 This is equivalent to "alkyl group". Preferably, linear or branched groups can be selected from methyl, ethyl, propyl, isopropyl, butyl, isobutyl and tert-butyl, pentyl, hexyl, heptyl, octyl, nonyl and decyl. More preferably, saturated linear or branched alkyl groups can be selected from methyl, ethyl, propyl, isopropyl, butyl, isobutyl and tert-butyl, pentyl, hexyl, heptyl and octyl, for example, methyl, ethyl, n-pentyl, n-nonyl, and isobutyl. - Saturated "cyclic C3-C8" hydrocarbon groups are monocyclic or bicyclic cycloalkyl groups containing 3-8 carbon atoms, and are particularly C5-C7 monocyclic cycloalkyl groups such as cyclohexyl groups. - An "alkoxy group" is an alkyl group that is linear or branched C1-C 16 The preferred group is an alkyloxy group, which is a C1-C8 hydrocarbon group. - When the alkoxy group is optionally substituted, this suggests that the alkyl group is optionally substituted as described above. - The "aryl" group represents a molten or non-molten monocyclic or bicyclic carbon-based group containing 5 to 12 carbon atoms, preferably 6 to 10 carbon atoms, where at least one ring is aromatic, and preferably the aryl group is a phenyl, biphenyl, naphthyl, and more preferably a phenyl group. - The term "at least one (species)" is synonymous with the term "one or more (species)". - In terms of concentration ranges, "including both ends" means that the upper and lower limits of that range are included within a given range.

[0052] Salts of the compounds of the following formulas (I), (I'), (II), or (II') include conventional non-toxic salts of the said compounds, such as those formed from organic or inorganic acids or organic or inorganic bases.

[0053] As salts of the compounds of formula (I), (I'), (II), or (II'), Compounds of formula (I) or (II) - For example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, magnesium hydroxide, lithium hydroxide, and inorganic bases such as sodium carbonate, potassium carbonate or calcium carbonate or bicarbonate, Or, - Primary, secondary, or tertiary alkylamines, such as triethylamine or butylamine, and other organic bases. Examples of salts obtained by adding to include the following. These primary, secondary, or tertiary alkylamines may contain one or more nitrogen and / or oxygen atoms, and therefore may contain, for example, one or more alcohol functional groups. In particular, examples include 2-amino-2-methylpropanol, ethanolamine, triethanolamine, 2-dimethylaminopropanol, 2-amino-2-(hydroxymethyl)-1,3-propanediol, and 3-(dimethylamino)propylamine.

[0054] Furthermore, salts of amino acids, such as lysine, arginine, guanidine, glutamic acid, and aspartic acid, can also be mentioned. Advantageously, salts of the compound of formula (I) or (II) (when it contains a carboxyl group) can be selected from alkali metal salts or alkaline earth metal salts, for example, sodium salts, potassium salts, calcium salts, or magnesium salts, and ammonium salts.

[0055] "Organic or inorganic salts" more specifically refers to salts selected from salts derived from i) hydrochloric acid (HCl), ii) hydrobromic acid (HBr), iii) sulfuric acid (H2SO4), iv) alkyl sulfonic acids: Alk-S(O)2OH, e.g., methanesulfonic acid and ethanesulfonic acid, v) aryl sulfonic acids: Ar-S(O)2OH, e.g., benzenesulfonic acid and toluenesulfonic acid, vi) citric acid, vii) succinic acid, viiii) tartaric acid, ix) lactic acid, x) alkoxysulfinic acids: Alk-OS(O)OH, e.g., methoxysulfinic acid and ethoxysulfinic acid, xi) aryloxysulfinic acids, e.g., tolueneoxysulfinic acid and phenoxysulfinic acid, xii) phosphoric acid (H3PO4), xiii) acetate (CH3C(O)OH), xiv) trifluoromethanesulfonic acid (CF3SO3H), and xv) tetrafluoroboric acid (HBF4).

[0056] The acceptable solvates of the compounds described herein include conventional solvates, such as those formed during the preparation of the compounds as a result of the presence of a solvent. Examples include solvates resulting from the presence of water or linear or branched alcohols, such as ethanol or isopropanol.

[0057] Optical isomers are, in particular, enantiomers and diastereoisomers.

[0058] Compound (I') is the tautomer form of compound (I) when the tautomer equilibrium exists according to the following scheme.

[0059] [ka]

[0060] According to one embodiment of the present invention, R1 represents a single hydrogen atom.

[0061] According to another embodiment of the present invention, R1 is linear (C1~C 10 ) Alkyl or branched (C3~C 10 ) represents an alkyl group, particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably ethyl. In particular, the alkyl group of R1 is not substituted.

[0062] According to one embodiment of the present invention, R2 represents one hydrogen atom.

[0063] According to another embodiment of the present invention, R2 is linear (C1~C 10 ) Alkyl or branched (C3~C 10 ) an alkyl group, particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably a methyl or ethyl group, and the alkyl group of R2 is not substituted.

[0064] According to another embodiment of the present invention, R2 is linear (C1~C 10 ) Alkyl or branched (C3~C 10 ) an alkyl group, particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably methyl or ethyl, wherein the alkyl group is substituted with one or more groups selected from i), ii), iii), and iv) above. Preferably, the alkyl group is substituted with one or two groups selected from i), ii), and iii), more preferably with one or two groups selected from i) and iii), and even better with one group iii) as a carboxyl group.

[0065] Another variant of the R2 group is one in which the alkyl group is substituted with one group iv), in particular with one phenyl group.

[0066] According to another embodiment of the present invention, R2 represents a (C3-C8) cycloalkyl group, preferably a (C5-C7) cycloalkyl group, such as cyclohexyl.

[0067] According to another embodiment of the present invention, R2 is optionally substituted with one or more hydroxyl and / or one or more C1-C8 alkoxy groups C5-C 12 This represents an aryl group, preferably an unsubstituted phenyl group.

[0068] According to one embodiment, R3 represents a hydrogen atom.

[0069] According to another embodiment, R3 is a saturated linear C1-C 10 Or branched C3~C 10 The alkyl group represents an alkyl group, particularly a linear (C1-C6) alkyl group or a branched (C3-C6) alkyl group, preferably a (C1-C4) alkyl group, such as a methyl group.

[0070] Preferably, the compounds of formula (I), either alone or in mixtures, and solvates such as their tautomers (I'), salts thereof, optical isomers thereof, racemates, and / or hydrates thereof, have the following meanings: R1 is a) Hydrogen atoms, and b) i)-O-R3 and ii)-S-R3, Selected from, which may be the same or different, and optionally substituted with one or more groups, preferably optionally substituted with one or more groups i) 、 Saturated linear C1-C6 or branched C3-C6 alkyl groups The base selected from is shown, R2 is a) A hydrogen atom and, b) i)-O-R3, ii)-S-R3, iii)-C(O)-O-R3, and iv) One or more hydroxyl and / or one or more C1-C4 alkoxy groups, for example, methoxy, which are optionally substituted with phenyl groups. A saturated linear C1-C1 chain is optionally substituted with one or more groups selected from i) and iii), which may be the same or different, preferably one or more groups selected from i) and iii), preferably substituted with iii) such as carboxyl. 10 Or branched C3~C 10 Or cyclic C3-C8, for example, C5-C6 hydrocarbon groups The base selected from is shown, R3 is a) Hydrogen atoms, and b) Saturated linear C1-C6 or branched C3-C6 alkyl groups The base selected from these is shown.

[0071] In particular, compounds of formula (I), either alone or in mixtures, and solvates such as tautomers (I') or salts thereof, optical isomers thereof, racemates, and / or hydrates thereof, have the following meanings: R1 is a) Hydrogen atoms, and b) i) A saturated linear C1-C4 or branched C3-C4 alkyl group, which is optionally substituted, more preferably unsubstituted, with one or more groups selected from i)-OR3, which may be the same or different. The base selected from is shown, R2 is a) A hydrogen atom and, b) i)-O-R3, iii)-C(O)-O-R3, iv) C5-C4 alkoxy groups optionally substituted with one or more hydroxyl groups and / or one or more C1-C4 alkoxy groups. 12 aryl group Saturated linear C1-C1 groups are optionally substituted with one or more groups, which may be identical or different, selected from the following. 10 Or branched C3~C 10 Or cyclic C3-C8, for example, C5-C6 hydrocarbon groups The base selected from is shown, R3 is a) Hydrogen atoms, and b) Saturated linear C1-C4 or branched C3-C4 alkyl groups, such as methyl or ethyl alkyl groups. The base selected from these is shown.

[0072] In particular, compounds of formula (I), either alone or in mixtures, and solvates such as tautomers (I') or salts thereof, optical isomers thereof, racemates, and / or hydrates thereof, have the following meanings: R1 is a hydrogen atom, R2 is a) Hydrogen atoms, and b) v) v) v) v) v) v) v) C(O) O) R3 is selected from one or more groups, which may be the same or different, and is substituted with one group iii) -C(O)-O) R3, and is selected from saturated linear C1-C5, branched C3-C5, or cyclic C3-C8, for example, C5-C6 hydrocarbon groups, where R2 is more preferably a saturated linear C1-C4 or branched C3-C4 hydrocarbon group substituted with one group iii) -C(O)-OR3. R3 is a) Hydrogen atoms, and b) Saturated linear C1-C4 or branched C3-C4 alkyl groups, such as methyl or ethyl alkyl groups. The base selected from these is shown.

[0073] In another preferred embodiment, the compound of formula (I) and its tautomer (I') are selected, either individually or as a mixture, from the following compounds of formula (II), their tautomers of formula (II'), their salts, their solvates and optical isomers, and their racemates.

[0074] [Table 2]

[0075] In formulas (II) and (II'), R1 and R3 have the same meanings as R1 and R3 in the compounds of formulas (I) and (I'), and X is an alkylene group -(CH2) n - indicates a range of 1 to 10 including both ends, preferably a range of 1 to 6, more preferably a range of 1 to 4, for example an integer of 1, and preferably R3 represents a hydrogen atom.

[0076] It is preferable to use the following compounds of formula (I), either individually or as a mixture, as well as their tautomers, or solvates such as their salts, optical isomers, racemates, and / or hydrates.

[0077] [Table 3A]

[0078] [Table 3B]

[0079] [Table 3C]

[0080] [Table 3D]

[0081] Of these compounds, the following compounds are more specifically preferred.

[0082] [Table 4A]

[0083] [Table 4B]

[0084] [Table 4C]

[0085] More preferably, among these compounds, the following compounds are even more specifically preferred.

[0086] [Table 5]

[0087] More preferably, among these compounds, the following compounds are even more specifically preferred.

[0088] [Table 6]

[0089] In the most preferred embodiment, the compound according to the present invention is as follows:

[0090] [Table 7]

[0091] All of the above compounds can be obtained from commercially available reagents by chemical methods known to those skilled in the art.

[0092] (a) The first compound can be prepared, for example, by means of the method described in EP-A-3390363 or WO2017 / 102349, which are incorporated herein by reference.

[0093] (a) The first compound may be an active ingredient or active compound in a cosmetic or dermatological product. As used herein, the term “active” ingredient or compound means an ingredient or compound having cosmetic or dermatological active properties such as antioxidant effect, whitening effect, UV shielding effect and antibacterial effect. The first compound (a) used in the present invention can function as a decolorizing agent, bleaching agent or whitening agent, and therefore the composition according to the present invention can be used as a whitening product or as a cosmetic composition for whitening keratinous substances.

[0094] (a) The first compound can be used as an agent for decolorizing, bleaching or whitening skin, body hair, eyelashes or scalp hair, and even lips and / or nails, preferably skin, particularly for removing pigmented spots or senescence spots, and / or as a sunscreen.

[0095] (a) A commercially available product can be used as the first compound. (a) An example of the first compound is Mexoryl SED, which is sold by Novell.

[0096] The amount of (a) the first compound in the composition according to the present invention may be 0.001% by mass or more, preferably 0.005% by mass or more, and more preferably 0.01% by mass or more, based on the total mass of the composition.

[0097] On the other hand, the amount of (a) the first compound in the composition according to the present invention may be 10% by mass or less, preferably 5% by mass or less, and more preferably 3% by mass or less, based on the total mass of the composition.

[0098] Therefore, the amount of (a) the first compound in the composition according to the present invention may be in the range of 0.001% to 10% by mass, preferably 0.005% to 5% by mass, and more preferably 0.01% to 3% by mass, based on the total mass of the composition.

[0099] (Second compound) The composition according to the present invention comprises (b) at least one second compound selected from ergothioneine and its derivatives. Two or more second compounds may be used in combination. Therefore, a single type of second compound or a combination of different types of second compounds can be used.

[0100] Ergothioneine and its derivatives may correspond to ergothioneine, as well as its salts, esters, and amides.

[0101] Ergothioneine has the following chemical structure.

[0102] [ka]

[0103] Ergothioneine can function as an antioxidant or reactive oxygen species scavenger. Examples of reactive oxygen species include singlet oxygen, superoxide ions (superoxide anion radicals), peroxide ions (hydrogen peroxide), and hydroxyl groups.

[0104] Ergothioneine derivatives are given by the following formula (II):

[0105] [ka]

[0106] (In the formula, X represents the -O-R', -OM, or -NR'R'' group, R, R', and R'' are hydrogen atoms, C1-C, either simultaneously or independently. 18 Represents an alkyl group, alkenyl group, or acyl group, (M represents a cation, such as a metal cation.) It could be equivalent to the following compound.

[0107] "C1~C 18The expression "alkyl group, alkenyl group or acyl group" means a linear or branched alkyl group, alkenyl group or acyl group containing 1 to 18 carbon atoms, optionally substituted with at least one substituent selected from a hydroxyl group (which may be esterified itself), a halogen atom, a carboxyl group and its derivatives, and an amine group and its derivatives, and optionally containing at least one heteroatom such as O and S in the chain.

[0108] Preferably, in the above chemical formula (II), R, R', and R'' represent a hydrogen atom or an ethyl group, acetyl group, or acyl group, either simultaneously or independently. Preferably, R represents a hydrogen atom or an ethyl group, acetyl group, or acyl group, and X represents NH2.

[0109] More preferably, (b) the second compound is ergothioneine, particularly L-(+)-ergothioneine, L-(-)-ergothioneine, D-(+)-ergothioneine, or D-(-)-ergothioneine. The most preferred compound according to the present invention is L-(+)-ergothioneine.

[0110] (b) A commercially available product may be used as the second compound. (b) An example of the second compound is Bioyouth® EGT Pure Ultrapure Ergothioneine, sold by Bloomage Biotech.

[0111] The amount of (b) the second compound in the composition according to the present invention may be 0.001% by mass or more, preferably 0.005% by mass or more, and more preferably 0.01% by mass or more, based on the total mass of the composition.

[0112] On the other hand, the amount of (b) the second compound in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less, based on the total mass of the composition.

[0113] Therefore, the amount of (b) the second compound in the composition according to the present invention may be in the range of 0.001% to 15% by mass, preferably 0.005% to 10% by mass, and more preferably 0.01% to 5% by mass, relative to the total mass of the composition.

[0114] The mass ratio of the amount of the first compound (a) to the amount of the second compound (b) in the composition according to the present invention may be 0.1 or more, preferably 0.2 or more, and more preferably 0.3 or more.

[0115] On the other hand, the mass ratio of the amount of the first compound (a) to the amount of the second compound (b) in the composition according to the present invention may be 3 or less, preferably 2 or less, and more preferably 1 or less.

[0116] Therefore, the mass ratio of the amount of the first compound (a) to the amount of the second compound (b) in the composition according to the present invention may be in the range of 0.1 to 3, preferably 0.2 to 2, and more preferably 0.3 to 1.

[0117] (water) The composition according to the present invention may contain (c) water.

[0118] The amount of (c) water in the composition according to the present invention may be 30% by mass or more, preferably 35% by mass or more, and more preferably 40% by mass or more, based on the total mass of the composition.

[0119] On the other hand, the amount of (c) water in the composition according to the present invention may be 99% by mass or less, preferably 95% by mass or less, and more preferably 90% by mass or less, based on the total mass of the composition.

[0120] Therefore, the amount of (c) water in the composition according to the present invention may be 30% to 99% by mass, preferably 35% to 95% by mass, and more preferably 40% to 90% by mass, based on the total mass of the composition.

[0121] (fatty substance) The composition according to the present invention may contain (d) at least one fatty substance. If two or more fatty substances are used, they may be the same or different.

[0122] In this specification, the term "fatty substance" means an organic compound that is substantially insoluble in water at room temperature (25°C) and atmospheric pressure (760 mmHg or 101325 Pa) (solubility less than 5% by mass, preferably less than 3% by mass, more preferably less than 1% by mass, and even more preferably less than 0.1% by mass).

[0123] On the other hand, (d) fatty substances may be soluble in organic solvents, such as chloroform, ethanol, benzene, or decamethylcyclopentasiloxane, under the same temperature and pressure conditions.

[0124] (d) The fatty substance may contain in its structure at least two consecutive siloxane groups or at least one hydrocarbon chain containing at least six carbon atoms. Within the scope of the present invention, it should be noted that (d) the fatty substance does not contain any C2-C3 oxyalkylene units or glycerol units.

[0125] (d) The fatty substance may be in liquid or solid form. In this specification, “liquid” and “solid” mean that (d) the fatty substance is in liquid or paste (non-solid) and solid form, respectively, at room temperature and atmospheric pressure. The term “solid” in this specification means a substance that is not fluid under its own mass, as opposed to a liquid.

[0126] (d) The fatty substance is preferably in the form of a liquid or paste, more preferably in the form of a liquid, at room temperature and atmospheric pressure. In this specification, the fatty substance (d) in the form of a liquid at room temperature and atmospheric pressure may be referred to as "oil".

[0127] (d) The fatty substance may be volatile or nonvolatile.

[0128] (d) The fatty substances may be selected from the group consisting of oils and butters of animal or plant origin, aliphatic hydrocarbons, synthetic glycerides, silicone oils, fatty esters (other than oils and butters of animal or plant origin), aliphatic alcohols, fatty acids, and mixtures thereof.

[0129] Examples of animal-derived oils include squalene, perhydrosqualene, and squalane.

[0130] Examples of plant-derived oils include, for example, linseed oil, camellia oil, macadamia nut oil, sunflower oil, apricot oil, soybean oil, arara oil, hazelnut oil, corn oil, mink oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, jojoba oil, almond oil, grape seed oil, sesame oil, and peanut oil.

[0131] Examples of plant-derived butters include, for example, shea butter or Butyrospermum parkii butter, Nilotica shea butter, garam butter, Borneo butter or fat or Tenkawan tallow (Shorea stenoptera), sal fat, Ilippe butter, Madhuca butter or (Bassia) Madhuca longifolia butter, Moi butter (Madhuca latifolia), Kachu butter (Madhuca mottleyana), Furuwara butter (M. butyracea), Mango butter (Mangifera indica), Murumuru butter (Astrocaryum murumuru), Kokum butter (Garcinia indica), Ukuba butter (Virola sebifera), Tucuma butter, Paneya butter (kpangnan) (Pentadesma butyracea), and Coffee butter (Coffea Examples include arabica butter, apricot butter (Prunus armeniaca), macadamia butter (Macadamia ternifolia), grape seed butter (Vitis vinifera), avocado butter (Persea gratissima), olive butter (Olea europaea), sweet almond butter (Prunus amygdalus dulcis), cocoa butter (Theobroma cacao), and sunflower butter.

[0132] In one embodiment of the present invention, it is preferable to use shea butter.

[0133] Examples of aliphatic hydrocarbons include, for example, linear or branched hydrocarbons such as mineral oil (e.g., liquid paraffin), paraffin, petrolatum or petrolatum, naphthalene, etc.; hydrogenated polyisobutene, isoeicosane, polydecene, hydrogenated polyisobutene, for example Parleam, and decene / butene copolymers, as well as mixtures thereof.

[0134] Other examples of aliphatic hydrocarbons include linear, branched, or sometimes cyclic lower alkanes, such as C6-C6. 16 , C9~C 12 and C 15 ~C 19 These are alkanes. Examples include hexane, undecane, dodecane, tridecane, and isoparaffins, such as isohexadecane and isodecane.

[0135] Examples of synthetic glycerides include, for instance, caprylic / capric triglyceride, such as that sold by Stearinerie Dubois, or by Dynamit Nobel under the names Miglyol® 810, 812, and 818.

[0136] Examples of silicone oils include linear organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; cyclic organopolysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane; and mixtures thereof.

[0137] Examples of fatty acid esters (esters of fatty acids and / or aliphatic alcohols) that differ from the aforementioned animal or plant-derived oils and butters and synthetic glycerides include saturated or unsaturated, linear or branched C1-C12 26 Aliphatic monoacid or polyacid and saturated or unsaturated linear or branched C1-C12 chains. 26 It is an ester with an aliphatic monoalcohol or polyalcohol, and the total number of carbon atoms in the ester is 10 or more.

[0138] Among monoesters, dihydroabiethyl behenate, octyldodecyl behenate, isocetyl behenate, cetyl lactate, and C lactate are examples. 12 ~C 15Alkyl, Isostearyl Lactate, Lauryl Lactate, Linoleyl Lactate, Oleyl Lactate, Isostearyl Octanoate, Isocetyl Octanoate, Octyl Octanoate, Cetyl Octanoate, Decyl Oleate, Isocetyl Isostearate, Isocetyl Laurate, Isocetyl Stearate, Isodecyl Octanoate, Isodecyl Oleate, Isononyl Isononanoate, Isostearyl Palmitate, Methyl Acetylricinoleate, Myristyl Stearate, Octyl Isononanoate, 2-Ethylhexyl Isononanoate, Octyl Palmitate, Octyl Pelargonate, Stearyl Examples include octyl palmate, octyldodecyl erucate, oleyl erucate, ethyl palmitate and isopropyl palmitate, 2-ethylhexyl palmitate, 2-octyldecyl palmitate, alkyl myristate, such as isopropyl myristate, butyl myristate, cetyl myristate, 2-octyldodecyl myristate, myristyl myristate or stearyl myristate, hexyl stearate, butyl stearate, isobutyl stearate, dioctyl malate, hexyl laurate, and 2-hexyldecyl laurate.

[0139] Furthermore, in relation to this transformation, C4~C 22 Dicarboxylic acids or tricarboxylic acids and C1-C 22 Esters of alcohols, as well as mono-, di-, or tricarboxylic acids and C2-C 26 Esters of di-, tri-, tetra-, or pentahydroxy alcohols can also be used.

[0140] In particular, the following can be mentioned: diethyl sebacate, diisopropyl sebacate, diisopropyl adipate, di-n-propyl adipate, dioctyl adipate, diisostearyl adipate, dioctyl maleate, glyceryl undecylenate, octyldodecyl stearoyl stearate, pentaerythrityl monolignolate, pentaerythrityl tetraisononanoate, pentaerythrityl tetra pelargonate, pentaerythrityl tetraisostearate, pentaerythrityl tetraoctanoate, propylene glycol dicaprylate, propylene glycol dicaprate, tridecyl erucate, triisopropyl citrate, triisostearyl citrate, glyceryl trilactate, glyceryl trioctanoate, trioctyldodecyl citrate, trioleyl citrate, propylene glycol dioctanoate, neopentyl glycol diheptanoate, diethylene glycol diisononanoate, and polyethylene glycol distearate.

[0141] Among the above esters, ethyl palmitate, isopropyl palmitate, myristyl palmitate, cetyl palmitate or stearyl palmitate, 2-ethylhexyl palmitate, 2-octyldodecyl palmitate, alkyl myristate, for example, isopropyl myristate, butyl myristate, cetyl myristate or 2-octyldodecyl myristate, etc., hexyl stearate, butyl stearate or isobutyl stearate, dioctyl malate, hexyl laurate, 2-hexyldecyl laurate, isononyl isononanoate or cetyl octanoate may preferably be used.

[0142] The composition according to the invention also contains, as a fatty ester, C6-C 30 , preferably C 12 -C 22Fatty acid sugar esters and diesters may also be included. The term "sugar" is recalled to mean an oxygen-bearing hydrocarbon compound that contains several alcohol functional groups, may or may not contain an aldehyde functional group or a ketone functional group, and contains at least 4 carbon atoms. These sugars may be monosaccharides, oligosaccharides or polysaccharides.

[0143] Examples of suitable sugars that can be mentioned include sucrose (or saccharose), glucose, galactose, ribose, fructose, maltose, mannose, arabinose, xylose, and lactose, and derivatives thereof, particularly alkyl derivatives such as methyl derivatives, for example methyl glucose.

[0144] The sugar esters of fatty acids can be particularly selected from the group consisting of esters or ester mixtures of the aforementioned sugars with linear or branched, saturated or unsaturated C6-C 30 preferably C [[ID=XI]] 12 ~C 22 fatty acids. When they are unsaturated, these compounds can contain 1 to 3 conjugated or non-conjugated carbon-carbon double bonds.

[0145] The esters according to this variant form can also be selected from mono-, di-, tri-, tetra-esters and polyesters, and mixtures thereof.

[0146] These esters can be selected, for example, from oleic acid esters, lauric acid esters, palmitic acid esters, myristic acid esters, behenic acid esters, coconut fatty acid esters, stearic acid esters, linoleic acid esters, linolenic acid esters, capric acid esters and arachidonic acid esters, or mixtures thereof, for example, particularly, oleo-palmitic acid, oleo-stearic acid and palmito-stearic acid mixed esters.

[0147] It may be more preferable to use monoesters and diesters, particularly mono- or dioleate esters, stearate esters, behenate esters, oleopalmitate esters, linoleate esters, linolenic acid esters, and oleostearate esters of sucrose, glucose, or methyl glucose.

[0148] One example that can be cited is the product sold by Amerchol under the name Glucate(registered trademark)DO, which is methyl glucose dioleate.

[0149] Other examples of sugar-fatty acid esters or ester mixtures that can be listed include the following: - Products sold by Croda, Inc. under the names Crodesta F160, F140, F110, F90, F70 and SL40, which represent sucrose palmitostearate and sucrose monolaurate, formed from 73% monoester and 27% diesters and triesters, 61% monoester and 39% diesters, triesters and tetraesters, 52% monoester and 48% diesters, triesters and tetraesters, 45% monoester and 55% diesters, triesters and tetraesters, and 39% monoester and 61% diesters, triesters and tetraesters, respectively. - Products sold under the name Ryoto Sugar Esters, for example, those corresponding to sucrose behenate formed from 20% monoester and 80% di-, tri-, polyester, with reference designation B370. - Sucrose mono-dipalmitostearate sold by Goldschmidt under the name Tegosoft® PSE.

[0150] (d) The fatty substance may be at least one type of fatty acid, or two or more types of fatty acids may be used.

[0151] Fatty acids should be in an acidic form (i.e., unchlorinated to avoid soap formation), may be saturated or unsaturated, contain 6 to 30 carbon atoms, particularly 9 to 30 carbon atoms, and are optionally substituted with one or more (particularly 1 to 4) hydroxyl groups. If they are unsaturated, these compounds may contain 1 to 3 conjugated or unconjugated carbon-carbon double bonds. More specifically, fatty acids are selected from myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, and isostearic acid.

[0152] (d) The fatty substance may be at least one aliphatic alcohol, or two or more aliphatic alcohols may be used.

[0153] The term "aliphatic alcohol" as used herein means any, saturated or unsaturated, linear or branched C8-C8 alcohol. 30 This refers to aliphatic alcohols, which are optionally substituted with one or more (especially 1 to 4) hydroxyl groups. If they are unsaturated, these compounds may contain 1 to 3 conjugated or unconjugated carbon-carbon double bonds.

[0154] C8~C 30 Among aliphatic alcohols, for example, C 12 ~C 22 Aliphatic alcohols can be used. These include lauryl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitrail alcohol, linolenyl alcohol, myristyl alcohol, arachidonyl alcohol, and erucyl alcohol, as well as mixtures thereof. In one embodiment, cetyl alcohol, stearyl alcohol, or mixtures thereof (e.g., cetearyl alcohol), and myristyl alcohol can be used as solid fatty substances. In another embodiment, isostearyl alcohol can be used as a liquid fatty substance.

[0155] In one embodiment of the present invention, (d) the fatty substance may be wax. As used herein, "wax" means a fatty substance that is substantially in solid form at room temperature (25 °C) under atmospheric pressure (760 mmHg or 101325 Pa) and generally has a melting point of 35 °C or higher. As the waxy fatty substance, waxes generally used in cosmetics can be used alone or in combinations thereof.

[0156] For example, the wax can be carnauba wax, microcrystalline wax, ozokerite, hydrogenated jojoba oil, polyethylene wax such as wax sold under the name "Performalene 400 Polyethylene" by New Phase Technologies, silicone wax, for example, products sold under the name "Abil Wax 9810" by Goldschmidt, poly(C 24 ~C 28 )alkylmethyldimethylsiloxane, palm butter, stearic acid C sold under the name "Kester Wax K82H" by Koster Keunen 20 ~C 40 alkyl, stearyl benzoate, shellac wax, and mixtures thereof. For example, waxes selected from carnauba wax, candelilla wax, ozokerite, hydrogenated jojoba oil, and polyethylene wax can be used. In at least one embodiment, the wax is preferably selected from candelilla wax and ozokerite, and mixtures thereof.

[0157] (d) The fatty substance is preferably selected from aliphatic hydrocarbons, vegetable oils, vegetable butters, and mixtures thereof, more preferably from aliphatic hydrocarbons, vegetable butters, and mixtures thereof, even more preferably from alkanes, shea butter, and mixtures thereof.

[0158] The amount of the (d) fatty substance in the composition according to the present invention may be 0.1% by mass or more, preferably 0.5% by mass or more, more preferably 1% by mass or more, based on the total mass of the composition.

[0159] On the other hand, the amount of the (d) fatty substance in the composition according to the present invention may be 15% by mass or less, preferably 10% by mass or less, more preferably 5% by mass or less, based on the total mass of the composition.

[0160] Therefore, the amount of the (d) fatty substance in the composition according to the present invention may be 0.1% to 15% by mass, preferably 0.5% to 10% by mass, more preferably 1% to 5% by mass, based on the total mass of the composition.

[0161] (Surfactant) The composition according to the present invention may contain (e) at least one surfactant. When two or more surfactants are used, they may be the same or different.

[0162] The (e) surfactant can be selected from the group consisting of (e1) anionic surfactants, (e2) cationic surfactants, (e3) amphoteric surfactants, (e4) nonionic surfactants, and mixtures thereof.

[0163] It is more preferable that the (e) surfactant is selected from (e4) nonionic surfactants.

[0164] The amount of the (e) surfactant in the composition according to the present invention may be 0.01% by mass or more, preferably 0.05% by mass or more, more preferably 0.1% by mass or more, based on the total mass of the composition.

[0165] On the other hand, the amount of the (e) surfactant in the composition according to the present invention may be 10% by mass or less, preferably 5% by mass or less, more preferably 1% by mass or less, based on the total mass of the composition.

[0166] Therefore, the amount of (e) surfactant in the composition according to the present invention may be 0.01% to 10% by mass, preferably 0.05% to 5% by mass, and more preferably 0.1% to 1% by mass, based on the total mass of the composition.

[0167] Anionic surfactants: (e1) Anionic surfactants are (C6~C 30 ) Alkyl sulfate, (C6~C 30 ) Alkyl ether sulfate, (C6~C 30 ) Alkylamide ether sulfate, alkylaryl polyether sulfate, monoglyceride sulfate, (C6~C 30 ) Alkyl sulfonates, (C6~C 30 ) Alkylamide sulfonate, (C6~C 30 ) Alkylaryl sulfonates, α-olefin sulfonates, paraffin sulfonates, (C6~C 30 ) alkyl phosphate, (C6~C 30 ) Alkyl sulfosuccinate, (C6~C 30 ) Alkyl ether sulfosuccinate, (C6~C 30 ) Alkylamide sulfosuccinate, (C6~C 30 ) Alkyl sulfoacetate, (C6~C 24 ) Acyl sarcosinate, (C6~C 24 ) Acyl glutamate, (C6~C 30 ) Alkyl polyglycoside carboxylic acid ether, (C6~C 30 ) Alkyl polyglycoside sulfosuccinate, (C6~C 30 ) Alkyl sulfosuccinate, (C6~C 24 ) Acyl isethionate, N-(C6~C 24 ) Acyl taurate, C6~C 30 Fatty acid salts, coconut oil acid salts, or hydrogenated coconut oil acid salts, (C8~C 20 ) Acyl lactylate, (C6~C 30 ) Alkyl-D-galactosidouronate, polyoxyalkylene (C6~C 30) Alkyl ether carboxylate, polyoxyalkylene (C6~C 30 ) Alkylaryl ether carboxylates, and polyoxyalkylenes (C6~C 30 It may be preferable to select from the group consisting of alkylamide ether carboxylates and the corresponding acid forms.

[0168] In at least one embodiment, (e1) the anionic surfactant is in the form of a salt, such as a salt of an alkali metal, e.g., sodium; a salt of an alkaline earth metal, e.g., magnesium; an ammonium salt; an amine salt; and an amino alcohol salt. Depending on the conditions, the anionic surfactant may also be in the form of an acid.

[0169] Cationic surfactants: (e2) Cationic surfactants can be optionally selected from the group consisting of primary, secondary, or tertiary fatty amine salts, quaternary ammonium salts, and mixtures thereof, which are polyoxyalkylened.

[0170] According to one embodiment, the (e2) cationic surfactant that can be used in the composition according to the present invention is selected from behenyltrimethylammonium chloride, cetyltrimethylammonium chloride, quaternium-83, quaternium-87, quaternium-22, behenylamidopropyl-2,3-dihydroxypropyldimethylammonium chloride, palmitylamidopropyltrimethylammonium chloride, and stearamidopropyldimethylamine.

[0171] Amphoteric surfactants: (e3) Amphoteric surfactants (zwitterionic surfactants) can be, for example (to list in no particular order), amine derivatives, such as aliphatic secondary or tertiary amines, and optionally quaternized amine derivatives, where the aliphatic group is linear or branched, containing 8 to 22 carbon atoms and at least one water-soluble anionic group (e.g., carboxylate, sulfonate, sulfate, phosphate, or phosphonate).

[0172] (e3) The amphoteric surfactant can preferably be selected from the group consisting of betaine and amidoamine carboxylated derivatives.

[0173] In one embodiment, (e3) the amphoteric surfactant may be selected from betaine-type surfactants.

[0174] Betaine-type amphoteric surfactants are preferably alkylbetaine, alkylamidealkylbetaine, sulfobetaine, phosphobetaine and alkylamidealkylsulfobetaine, specifically (C8~C 24 ) Alkyl betaine, (C8~C 24 )Alkylamide (C1~C8) alkylbetaine, sulfobetaine and (C8~C 24 )Selected from the group consisting of alkylamide (C1-C8) alkyl sulfobetaine. In one embodiment, the betaine-type (e3) amphoteric surfactant is (C8-C 24 ) Alkyl betaine, (C8~C 24 ) Selected from alkylamide (C1-C8) alkyl sulfobetaine, sulfobetaine, and phosphobetaine.

[0175] Non-limiting examples that can be cited include compounds classified in the CTFA International Cosmetic Ingredient Dictionary & Handbook, 15th edition, 2014, either individually or in mixtures, under the names cocobetaine, laurylbetaine, cetylbetaine, coco / oleamidopropylbetaine, cocamidopropylbetaine, palmitamidopropylbetaine, stearamidopropylbetaine, cocamidoethylbetaine, cocamidopropylhydroxysultaine, oleamidopropylhydroxysultaine, cocohydroxysultaine, laurylhydroxysultaine, and cocosultaine.

[0176] The betaine-type amphoteric surfactants are preferably alkyl betaines and alkylamide alkyl betaines, specifically cocobetaine and cocamidopropyl betaine.

[0177] (Nonionic surfactant) (e4) Nonionic surfactants can be selected from alkyl and polyalkyl esters of poly(ethylene oxide), alkyl and polyalkyl ethers of poly(ethylene oxide), oxyalkylened alcohols, optionally polyoxyethylene-converted alkyl and polyalkyl esters of sorbitan, optionally polyoxyethylene-converted alkyl and polyalkyl ethers of sorbitan, alkyl and polyalkyl glycosides or polyglycosides, particularly alkyl and polyalkyl glucosides or polyglucosides, alkyl and polyalkyl esters of sucrose, optionally polyoxyethylene-converted alkyl and polyalkyl esters of glycerol, optionally polyoxyethylene-converted alkyl and polyalkyl ethers of glycerol, and mixtures thereof.

[0178] In one embodiment, the (e4) nonionic surfactant may be selected from polyglyceryl fatty acid esters.

[0179] Polyglyceryl fatty acid esters may have a polyglycerol portion derived from 2 to 10 glycerol units, preferably 2 to 8 glycerol units, more preferably 2 to 6 glycerol units. In other words, polyglyceryl fatty acid esters may contain 2 to 10 polyglyceryl units, preferably 2 to 8 polyglyceryl units, more preferably 2 to 6 polyglyceryl units.

[0180] Polyglyceryl fatty acid esters can be selected from mono, di, and triesters of linear or branched saturated or unsaturated fatty acids, preferably saturated fatty acids, containing 4 to 32 carbon atoms, preferably 8 to 26 carbon atoms, more preferably 10 to 20 carbon atoms, such as lauric acid, oleic acid, stearic acid, isostearic acid, capric acid, caprylic acid, and myristic acid.

[0181] (e4) The nonionic surfactant is preferably selected from saturated or unsaturated polyglyceryl fatty acid monoesters.

[0182] Polyglyceryl fatty acid esters may have an HLB (hydrophilic-lipophilic balance) value of 7.0 to 16.0, preferably 7.5 to 15.5, and more preferably 8.0 to 15.0. The term HLB ("hydrophilic-lipophilic balance") is well known to those skilled in the art and reflects the ratio between the hydrophilic and lipophilic parts of a molecule. When two or more polyglyceryl fatty acid esters are used, the HLB value is determined by the weighted average of the HLB values ​​of all polyglyceryl fatty acid esters.

[0183] Polyglyceryl fatty acid esters include PG-2 caprate (HLB: 9.5), PG-2 laurate (HLB: 8.5), PG-4 oleate (HLB: 8.8), PG-4 laurate (HLB: 10.4), PG-4 isostearate (HLB: 8.2), PG-5 laurate (HLB: 15.8), PG-6 isostearate (HLB: 10.8), PG-3 coconut fatty acid (HLB: 12.0), and PG-3 caprate (HLB: 10.8). It may be selected from the group consisting of B:10.0), caprylic acid PG-4 (HLB:14), capric acid PG-4 (HLB:14.0), myristate acid PG-5 (HLB:15.4), stearate PG-5 (HLB:15.0), oleate PG-5 (HLB:14.9), caprylic acid PG-6 (HLB:14.6), capric acid PG-6 (HLB:13.1), laurate PG-6 (HLB:14.5), and mixtures thereof.

[0184] (e4) The nonionic surfactant may preferably be selected from polyglyceryl fatty acid esters, more preferably polyglyceryl saturated fatty acid esters, and even more preferably polyglyceryl saturated fatty acid monoesters such as PG-4 caprate.

[0185] (pH) The pH of the aqueous phase of the composition according to the present invention may be 3 to 7, preferably 4 to 6.5, and more preferably 5 to 6.

[0186] The pH of the composition according to the present invention can be adjusted by adding at least one alkaline agent and / or at least one acid.

[0187] The pH of the composition according to the present invention can also be adjusted by adding at least one buffering agent.

[0188] Alkaline agent: The composition according to the present invention may contain at least one alkaline agent. Two or more alkaline agents can be used in combination. Therefore, a single type of alkaline agent or a combination of different types of alkaline agents can be used.

[0189] The alkaline agent may be an inorganic alkaline agent. The inorganic alkaline agent is preferably selected from the group consisting of ammonia, alkali metal hydroxides, alkaline earth metal hydroxides, alkali metal phosphates, and monohydrogen phosphates, such as sodium phosphate or monohydrogen phosphate.

[0190] Examples of inorganic alkali metal hydroxides include sodium hydroxide and potassium hydroxide. Examples of alkaline earth metal hydroxides include calcium hydroxide and magnesium hydroxide. Sodium hydroxide is preferred as the inorganic alkali agent.

[0191] The alkaline agent may be an organic alkaline agent. The organic alkaline agent is preferably selected from the group consisting of monoamines and their derivatives; diamines and their derivatives; polyamines and their derivatives; basic amino acids and their derivatives; oligomers and their derivatives of basic amino acids; polymers and their derivatives of basic amino acids; urea and its derivatives; and guanidine and its derivatives.

[0192] Examples of organic alkaline agents include alkanolamines, such as mono-, di-, and triethanolamines, as well as isopropanolamines, urea, guanidine and their derivatives, basic amino acids, such as ornithine, and diamines, for example, the following structure:

[0193] [ka]

[0194] (In the formula, R represents propylene optionally substituted with an alkylene, such as a hydroxyl group or a C1-C4 alkyl group, and R1, R2, R3, and R4 independently represent a hydrogen atom, an alkyl group, or a C1-C4 hydroxyalkyl group. Examples of such compounds include 1,3-propanediamine and its derivatives, which can be expressed as follows:

[0195] Depending on their solubility, the alkaline agent can be used in a total amount of 0.01% to 15% by mass, preferably 0.02% to 10% by mass, and more preferably 0.03% to 5% by mass, relative to the total mass of the composition.

[0196] acid: The composition according to the present invention may contain at least one acid. Two or more acids can be used in combination. Therefore, a single type of acid or a combination of different types of acids can be used.

[0197] Examples of acids include any inorganic or organic acid commonly used in cosmetics, preferably inorganic acids. Monohydric acids and / or polyhydric acids may be used. Monohydric acids such as citric acid, lactic acid, sulfuric acid, phosphoric acid, and hydrochloric acid (HCl) can be used. Lactic acid may be preferred in some cases.

[0198] Depending on their solubility, acids may be used in a total amount of 0.01% to 15% by mass, preferably 0.02% to 10% by mass, and more preferably 0.03% to 5% by mass, relative to the total mass of the composition.

[0199] (Other optional additives) The compositions according to the present invention may also contain, for example, any of the following optional additives commonly used in the cosmetics field, selected from solvents, thickeners, fillers, UV shielding agents, fatty acids, cosmetic surfactants other than component (a), preservatives, and mixtures thereof.

[0200] It is common practice for those skilled in the art to adjust the properties and amounts of the optional additives that may be present in the composition according to the present invention so that the desired cosmetic properties are not affected by the additives.

[0201] Examples of solvents include one or more organic solvents that are acceptable for cosmetic use, which include alcohols, especially monohydric alcohols such as ethyl alcohol, isopropyl alcohol, benzyl alcohol, and phenylethyl alcohol; diols such as ethylene glycol, propylene glycol, and butylene glycol; other polyols such as glycerol, sugars, and sugar alcohols; and ethers such as ethylene glycol monomethyl, monoethyl, and monobutyl ethers, propylene glycol monomethyl, monoethyl, and monobutyl ethers, and butylene glycol monomethyl, monoethyl, and monobutyl ethers.

[0202] The organic solvent may be present in the composition at a concentration of 0.01% to 30% by mass, preferably 0.05% to 20% by mass, and more preferably 0.1% to 10% by mass, relative to the total mass of the composition.

[0203] (preparation) The composition according to the present invention can be prepared by mixing the above-mentioned essential components and optional components in a conventional manner.

[0204] For example, the composition according to the present invention is (a) at least one first compound as described above, and (b) at least one second compound as described above It can be prepared by a method that includes a step of mixing the ingredients.

[0205] Any of the optional components can be further mixed in.

[0206] The mixing can be carried out at any temperature, such as room temperature (e.g., 20-25°C, preferably 25°C), preferably 30°C or higher, preferably 40°C or higher, and more preferably 50°C or higher. Further mixing with any of the above-mentioned optional components, such as pH adjusters, is preferable.

[0207] The composition according to the present invention is not particularly limited in form and may take various forms such as W / O emulsion, O / W emulsion, gel, or solution. It is preferable that the composition according to the present invention is in the form of an emulsion, preferably an O / W emulsion, and more preferably an O / W gel emulsion.

[0208] [Beauty method] The composition according to the present invention can be used as a cosmetic or dermatological composition, preferably a cosmetic composition, and more preferably a cosmetic composition for keratinous substances. Examples of keratinous substances include skin, scalp, hair, mucous membranes such as lips, and nails. The composition according to the present invention is even more preferably a skin cosmetic composition.

[0209] The composition according to the present invention can be used as a decolorizing, bleaching, or whitening product for keratinous substances such as skin. In particular, the composition according to the present invention can be used as a whitening product.

[0210] The compositions according to the present invention may be used for keratinous substances such as skin, scalp, and / or lips, preferably for application to the skin.

[0211] Therefore, the compositions according to the present invention can be used in cosmetic methods for keratinous materials, preferably for skin. In one embodiment, the present invention relates to a cosmetic method, preferably a whitening method, for keratinous materials, preferably for skin, comprising the step of applying the compositions according to the present invention to the keratinous material.

[0212] The compositions according to the present invention can be used as topical cosmetic compositions in the form of lotions, emulsions, creams, gels, pastes, serums, foams, or sprays.

[0213] [use] The present invention also relates to (a) at least one first compound selected from (a) compounds of formula (I) below, tautomers of formula (I') below, salts thereof, solvates such as hydrates thereof, optical isomers thereof, racemates thereof, and mixtures thereof:

[0214] [ka]

[0215] (In the formula, R1 is a) Hydrogen atoms, and b) i)-O-R3 and ii)-S-R3 Saturated linear C1-C1 groups are optionally substituted with one or more groups, which may be identical or different, selected from the following. 10 Or branched C3~C 10 alkyl group The base selected from is shown, R2 is a) A hydrogen atom and, b) i)-O-R3, ii)-S-R3, iii)-C(O)-O-R3, and iv) C5-C8 alkoxy groups optionally substituted with one or more hydroxyl groups and / or one or more C1-C8 alkoxy groups. 12 aryl group A saturated linear C1-C molecule, optionally substituted with one or more groups, which may be identical or different, selected from the above. 12 Or branched C3~C 12 or a cyclic C3-C8 hydrocarbon group, c) C5-C8 atoms optionally substituted with one or more hydroxyl and / or one or more C1-C8 alkoxy groups. 12 Aryl group and The base selected from is shown, During the ceremony, R3 is a) Hydrogen atoms, and b) Saturated linear C1-C 10 Or branched C3~C 10 alkyl group (b) the use of at least one second compound selected from ergothioneine and its derivatives in a composition comprising a group selected from (a), which also relates to the use of (a) the first compound for stabilization.

[0216] The term "stabilize" has the same meaning as "enhance stability."

[0217] The use according to the present invention can enhance the stability of (a) the first compound in a composition containing (a) the first compound.

[0218] Therefore, the use according to the present invention makes it possible to (a) store a composition containing the first compound for a long period of time, especially under high temperature conditions.

[0219] The above description relating to (a) the first compound and (b) the second compound for compositions according to the present invention may also apply to those used in the use according to the present invention.

[0220] A composition used according to the present invention may contain any of the optional components described above with respect to the compositions according to the present invention. [Examples]

[0221] The present invention will be described in more detail by reference to examples. However, these examples should not be construed as limiting the scope of the present invention.

[0222] (Example 1 and Comparative Examples 1-6) [Preparation] Each of the compositions from Example 1 and Comparative Examples 1-6 was prepared by mixing the components shown in Table 1. All numerical values ​​for the amounts of components are based on the "mass%" of the active material.

[0223] [Table 8]

[0224] 2-Mercaptonicotinoylglycine: N-[(2-thioxo-1,2-dihydropyridine-3-yl)carbonyl]glycine (compound 20) [evaluation] (Residual rate of thiopyridinone compounds) 1.0 g of each composition from Example 1 and Comparative Examples 1-6 was mixed with 50 mL of water to prepare an aqueous solution of the composition. Methanol was added to the aqueous solution of the composition, and it was subjected to sonication, followed by stirring for approximately 1.5 hours. The resulting solution was filtered.

[0225] At the following timings (1), a portion of the filtrate was subjected to HPLC-UV analysis to determine the amount of thiopyridinone compound (2-mercaptonicotinoylglycine).

[0226] At the following timing (2), another portion of the filtrate was placed in a sealed, light-shielding container at 55°C for 2 hours and subjected to HPLC-UV analysis to determine the amount of thiopyridinone compound (2-mercaptonicotinoylglycine).

[0227] At the following timing (3), another portion of the filtrate was placed in a sealed, light-shielding container at 45°C for 2 months and subjected to HPLC-UV analysis to determine the amount of thiopyridinone compound (2-mercaptonicotinoylglycine). Timing (1) Immediately after preparation (T0) Timing (2) Two weeks after preparation (T2W) Timing (3) Two months after preparation (T2M)

[0228] Details of the HPLC-UV assay are as follows:

[0229] Equipment / Reagents

[0230] [Table 9]

[0231] HPLC conditions

[0232] [Table 10]

[0233] The residue rate of thiopyridinone compounds was determined by the following formula: Residual rate of thiopyridinone compounds in T2W (%) = Amount of thiopyridinone compound at timing (2) / Amount of thiopyridinone compound at timing (1) Residual rate of thiopyridinone compounds in T2M (%) = Amount of thiopyridinone compound at timing (3) / Amount of thiopyridinone compound at timing (1) The results are shown in the rows "Percentage of thiopyridinone compounds remaining in T2W (%)" and "Percentage of thiopyridinone compounds remaining in T2M (%)" in Table 2 below.

[0234] [Table 11]

[0235] (result) The composition according to Example 1, which contained ergothioneine, remained stable for a long period even at high temperatures, and as a result, it contained a larger amount of thiopyridinone compound than the compositions according to Comparative Examples 1 to 6, which either did not contain ergothioneine or contained different amino acids (serine, aspartic acid, or histidine), amino acid peptides (carnosine), or amino acid analogs (taurine).

Claims

1. (a) At least one first compound selected from the compounds of formula (I), tautomers of formula (I'), salts thereof, solvates such as hydrates thereof, optical isomers thereof, racemates thereof, and mixtures thereof: 【Chemistry 1】 (In the formula, R 1 teeth, a) Hydrogen atoms, and b) i)-OR 3 and ii)-SR 3 A saturated linear C, which is optionally substituted with one or more groups, which may be the same or different, selected from the following: 1 ~C 10 or branched C 3 ~C 10 alkyl group The base selected from is shown, R 2 teeth, a) A hydrogen atom and, b) i)-O-R 3 、 ii)-SR 3 、 iii)-C(O)-OR 3 ,and iv) One or more hydroxyls and / or one or more C 1 ~C 8 C is optionally substituted with an alkoxy group. 5 ~C 12 aryl group A saturated linear C, which is optionally substituted with one or more groups, which may be the same or different, selected from the following: 1 ~C 12 or branched C 3 ~C 12 or ring C 3 ~C 8 hydrocarbon group, c) One or more hydroxyls and / or one or more C 1 ~C 8 C is optionally substituted with an alkoxy group. 5 ~C 12 Aryl group and The base selected from is shown, During the ceremony, R 3 teeth, a) Hydrogen atoms, and b) Saturated linear C 1 ~C 10 or branched C 3 ~C 10 alkyl group (Indicates the base selected from) and (b) At least one second compound selected from ergothioneine and its derivatives A composition comprising, preferably a cosmetic composition, more preferably a skin cosmetic composition.

2. R of equations (I) and (I') 1 But does it represent a hydrogen atom? or R of equations (I) and (I') 1 However, linear (C 1 ~C 10 ) alkyl group or branched (C 3 ~C 10 ) alkyl groups, especially linear (C) 1 ~C 6 ) alkyl group or branched (C 3 ~C 6 ) Represents an alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably ethyl, and especially R 1 The alkyl group is not substituted. The composition according to claim 1.

3. R of equations (I) and (I') 2 But does it represent a hydrogen atom? or R of equations (I) and (I') 2 However, linear (C 1 ~C 10 ) alkyl group or branched (C 3 ~C 10 ) alkyl groups, especially linear (C) 1 ~C 6 ) alkyl group or branched (C 3 ~C 6 ) Represents an alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably a methyl or ethyl group, R 2 The alkyl group is not substituted. The composition according to claim 1 or 2.

4. R of equations (I) and (I') 2 However, linear (C 1 ~C 10 ) Alkyl or branched (C 3 ~C 10 ) alkyl groups, especially linear (C) 1 ~C 6 ) Alkyl or branched (C 3 ~C 6 The composition according to claim 1 or 2, wherein the alkyl group represents an alkyl group, preferably methyl, ethyl, n-pentyl, n-nonyl, or isobutyl, more preferably methyl or ethyl, and the alkyl group is substituted with one or more groups selected from i), ii), iii) and iv) as defined above, preferably the alkyl group is substituted with one or two groups selected from i), ii) and iii), more preferably one or two groups selected from i) and iii), and even better, one group iii) as a carboxyl group.

5. R of equations (I) and (I') 2 However, (C 3 ~C 8 )Cycloalkyl groups, preferably (C 5 ~C 7 ) Represents a cycloalkyl group, for example, cyclohexyl, or R of equations (I) and (I') 2 However, one or more hydroxyls and / or one or more C 1 ~C 8 C is optionally substituted with an alkoxy group. 5 ~C 12 Representing an aryl group, preferably an unsubstituted phenyl group, The composition according to claim 1 or 2.

6. R of equations (I) and (I') 3 But does it represent a hydrogen atom? or R of equations (I) and (I') 3 However, saturated linear C 1 ~C 10 Or branched C 3 ~C 10 Alkyl groups, especially linear (C) 1 ~C 6 ) alkyl group or branched (C 3 ~C 6 ) Alkyl alkyl group, preferably (C 1 ~C 4 ) Represents an alkyl group, for example, a methyl group, The composition according to any one of claims 1 to 5.

7. R of equations (I) and (I') 1 but, a) Hydrogen atoms, and b) i)-OR 3 and ii)-SR 3 One or more groups, which may be the same or different, selected from, optionally substituted with one or more groups, preferably optionally substituted with one or more groups i), saturated linear C 1 ~C 6 or branched C 3 ~C 6 alkyl group Represents a base selected from, R of equations (I) and (I') 2 but, a) A hydrogen atom and, b) i)-O-R 3 、 ii)-SR 3 、 iii)-C(O)-OR 3 ,and iv) one or more hydroxyl and / or one or more C 1 -C 4 an alkoxy group, for example a phenyl group optionally substituted with methoxy, one or more groups, which may be the same or different, optionally substituted with one or more groups selected from, preferably one or more groups selected from i) and iii), preferably substituted with iii) such as carboxy, a saturated straight-chain C 1 -C 10 or branched C 3 -C 10 or cyclic C 3 -C 8 for example C 5 -C 6 hydrocarbon group and Represents a base selected from, R of equations (I) and (I') 3 but, a) Hydrogen atoms, and b) Saturated linear C 1 ~C 6 or branched C 3 ~C 6 alkyl group Represents a base selected from, In preference, the compounds of formula (I) and their tautomers (I'), their salts, solvates such as their hydrates, their optical isomers, their racemates, and mixtures thereof have the following meanings: R of equations (I) and (I') 1 but a) Hydrogen atoms, and b) i)-OR 3 A saturated linear C, which is optionally substituted, more preferably unsubstituted, with one or more groups, which may be the same or different, selected from the above. 1 ~C 4 or branched C 3 ~C 4 alkyl group Represents a base selected from, R of equations (I) and (I') 2 but, a) A hydrogen atom and, b) i)-O-R 3 、 iii)-C(O)-OR 3 ,and iv) One or more hydroxyls and / or one or more C 1 ~C 4 C is optionally substituted with an alkoxy group. 5 ~C 12 aryl group A saturated linear C, which is optionally substituted with one or more groups, which may be the same or different, selected from the following: 1 ~C 10 or branched C 3 ~C 10 or ring C 3 ~C 8 For example, C 5 ~C 6 hydrocarbon group and Represents a base selected from, R of equations (I) and (I') 3 but, a) Hydrogen atoms, and b) Saturated linear C 1 ~C 4 or branched C 3 ~C 4 Alkyl alkyl groups, such as methyl or ethyl Represents a base selected from, The composition according to any one of claims 1 to 6.

8. (a) The composition according to any one of claims 1 to 7, wherein the first compound is one of the following compounds 1 to 24, their tautomers, their salts, solvates such as their hydrates, their optical isomers, their racemates, and mixtures thereof, particularly compounds 1, 2, 4, 6, 7, 9, 11, 12, 14, 15, 16, 17, 18, 19, 20, or 21, more specifically 1, 9, 16, 18, 19, 20, or 21, preferably selected from 18, 19, 20, or 21, more preferably 20. Table 1A Table 1B 【Table 1C】 【Table 1D】

9. The composition according to any one of claims 1 to 8, wherein the amount of (a) the first compound in the composition is 0.001% to 10% by mass, preferably 0.005% to 5% by mass, and more preferably 0.01% to 3% by mass, based on the total mass of the composition.

10. (b) The second compound is of the following chemical formula (II): 【Chemistry 2】 (In the formula, X represents the -O-R', -OM, or -NR'R'' group, R, R', and R'' are hydrogen atoms, C, either simultaneously or independently. 1 ~C 18 Representing an alkyl group, alkenyl group, or acyl group, the alkyl group, alkenyl group, or acyl group is linear or branched and optionally substituted with at least one substituent selected from esterified hydroxyl groups, halogen atoms, carboxyl groups and their derivatives, and amine groups and their derivatives, and optionally contains at least one heteroatom such as O and S in the chain. (M represents a cation, such as a metal cation.) The composition according to any one of claims 1 to 9, as represented by [the specified method].

11. In chemical formula (II), the R, R', and R'' groups simultaneously or independently represent a hydrogen atom or an ethyl group, acetyl group, or acyl group, preferably R represents a hydrogen atom or an ethyl group, acetyl group, or acyl group, and X represents NH 2 The composition according to claim 10, which shows the following.

12. (b) The composition according to claim 10 or 11, wherein the second compound is ergothioneine.

13. The composition according to any one of claims 1 to 11, wherein the amount of (b) the second compound in the composition is 0.001% to 15% by mass, preferably 0.005% to 10% by mass, and more preferably 0.01% to 5% by mass, based on the total mass of the composition.

14. A keratin substance, preferably a cosmetic method for the skin, preferably a whitening method, A step of applying the composition according to any one of claims 1 to 13 to a keratin substance. Methods that include...

15. (a) At least one first compound selected from the compounds of formula (I), tautomers of formula (I'), salts thereof, solvates such as hydrates thereof, optical isomers thereof, racemates thereof, and mixtures thereof: 【Transformation 3】 (In the formula, R 1 teeth, a) Hydrogen atoms, and b) i)-OR 3 and ii)-SR 3 A saturated linear C, which is optionally substituted with one or more groups, which may be the same or different, selected from the following: 1 ~C 10 or branched C 3 ~C 10 alkyl group The base selected from is shown, R 2 teeth, a) A hydrogen atom and, b) i)-O-R 3 、 ii)-SR 3 、 iii)-C(O)-OR 3 ,and iv) One or more hydroxyls and / or one or more C 1 ~C 8 C is optionally substituted with an alkoxy group. 5 ~C 12 aryl group A saturated linear C, which is optionally substituted with one or more groups, which may be the same or different, selected from the following: 1 ~C 12 or branched C 3 ~C 12 or ring C 3 ~C 8 hydrocarbon group, c) One or more hydroxyls and / or one or more C 1 ~C 8 C is optionally substituted with an alkoxy group. 5 ~C 12 Aryl group and The base selected from is shown, During the ceremony, R 3 teeth, a) Hydrogen atoms, and b) Saturated linear C 1 ~C 10 or branched C 3 ~C 10 alkyl group (Indicates the base selected from) (b) use of at least one second compound selected from ergothioneine and its derivatives in a composition comprising (a) use for stabilizing the first compound.

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