Synergistic preservative / personal care composition containing polyglycerol esters

Abstract

The present invention provides preservative compositions that can be used as preservatives in various compositions, including personal care formulations, and methods for increasing the efficacy of preservatives in final-use formulations. [Solution] (i) A preservative comprising an acid compound, a phenol compound, a sulfite, an iron chelating agent, an aromatic alcohol, a quaternary ammonium compound, a pyrone compound, a urea compound, an imidazole compound, an isothiazolinone compound, or a combination of two or more preservatives; and (ii) a preservative composition comprising a polyglycerol ester present in an amount that sufficiently increases the efficacy of the preservative compared to the preservative alone, and the amount of increase is greater than the additive effect of the biocidal activity of the preservative and the polyglycerol ester used alone, wherein the weight ratio of the polyglycerol ester to the preservative is in the range of 0.0001 to 2.0.

Description

[Technical Field]

[0001]

[0002] This disclosure provides for a preservative composition that has enhanced preservative properties compared to a preservative composition containing a preservative itself. This invention relates to a preservative composition containing preservatives and enhancing agents.

[0002]

[0003] [Background technology]

[0003]

[0004] Microbial contamination of personal care products, cosmetics, home care products and other similar products Contamination is a critical issue for industries and can be a major cause of both product and economic loss of end-use formulations. Furthermore, contamination of cosmetic and home care products can result in them becoming hazardous to consumers. Preservatives and preservative compositions for protecting and preserving end-use formulations against microbial attacks from bacteria or fungi are well known in the art. These preservatives and compositions have a wide variety of applications in areas such as personal care products, cosmetics, home care products, and health and hygiene products. Conventional preservatives and compositions have used traditional active ingredients that provide good bactericidal and fungicidal properties against microbial attacks.

[0004]

[0005] Ideally, the preservative or composition should be effective against all types of microorganisms. It has broad-spectrum activity at various pH levels. The preservative or composition must also be highly potent, allowing for the use of minimal amounts of preservatives to reduce costs and avoid or mitigate potential adverse effects caused by preservatives or multiple preservatives in the preservative composition. Furthermore, it is desirable that the preservative or composition be stable against all temperature changes it faces during manufacturing, packaging, and transport, as well as during storage of the final formulation in which it is contained. In addition, the components of an ideal preservative or preservative composition should be physically and chemically compatible with the raw materials present in various final-use formulations, so that one preservative or preservative composition can be suitably incorporated into a variety of products.

[0005]

[0006] In recent developments in the field of preservatives, the effectiveness of preservatives (multiple preservatives) has been enhanced. Significant efforts have been made to find compounds that synergistically interact with preservatives to effectively reduce the amount of preservatives required for a preservative formulation with desired preservative properties, while achieving the desired level of preservation using the minimum amount of preservatives and / or preservatives. This is a result of ongoing regulatory pressure to reduce the amount of preservatives in final-use formulations.

[0006]

[0007] Similarly, personal care products containing active ingredients to treat specific conditions such as dandruff. In the field of formulations, regulatory pressure to reduce the amount of active ingredients in personal care formulations continues. One way to reduce the amount of active ingredients is to form a synergistic mixture of the active ingredient and an enhancer, which increases the potency of the active ingredient and thus enhances the potency of the active ingredient in the personal care formulation.

[0007]

[0009] [Overview of the Initiative] [Means for solving the problem]

[0008]

[0008] This disclosure relates to the use of preservatives in various compositions including personal care formulations. To provide a synergistic mixture of a preservative and a polyglycerol ester compound that can be used. This provides an answer to that need.

[0009]

[0010] In one embodiment, (i) preservatives; and (ii) the effectiveness of preservatives compared to preservatives alone. The present invention provides a preservative composition containing a polyglycerol ester present in an amount sufficient to significantly increase its biocide activity, and the amount of increase is greater than the additive effect of the biocide activity of the preservative and the polyglycerol ester used alone.

[0010]

[0011] In another embodiment, the weight ratio of polyglycerol ester to preservative is 0.0000 The present invention provides a preservative composition with a range of 1 to 10.0; more specifically, a range of 0.0001 to 2.0; more specifically, a range of 0.001 to 1.5; and most specifically, a range of 0.01 to 1.0.

[0011]

[0012] In another embodiment, the preservative composition includes an acid compound, an aldehyde, a phenol compound, and The preservative is either a luphite, an iron chelating agent, an aromatic alcohol, a quaternary ammonium compound, a pyrone compound, a urea compound, an imidazole compound, or an isothiazolinone compound, or a combination of two or more preservatives.

[0012]

[0013] In certain embodiments, the preservative composition contains an iron chelating agent, and the iron chelating agent The compounds include pyrithione compounds, piroctone olamine, 2-pyridinol-1-oxide, N-hydroxy-6-octyloxypyridine 2(1H)-one, N-hydroxy-6-octyloxypyridine 2(1H)-one ethanolamine salt, or mixtures thereof. Certain pyrithione compounds contain preservatives, including zinc pyrithione, sodium pyrithione, or mixtures thereof.

[0013]

[0014] In one embodiment of this disclosure, the preservative is an acid compound. The acid compound is an acid, an acidic compound. It may be a tel or an acid salt. In certain embodiments, the acid compound includes benzoic acid, propionic acid, salicylic acid, sorbic acid, formic acid, undeca-10-enoic acid, lactic acid, glycolic acid, and citric acid, or salts thereof.

[0014]

[0015] In another embodiment, the preservative is a quaternary ammonium compound. Ammonium compounds include alkyl(C12-C22)trimethylammonium compounds, benzethonium compounds, or mixtures thereof.

[0015]

[0016] In further embodiments, the preservative includes alcohol. The alcohol is a lower alcohol. Contains kill alcohol or aromatic alcohol. A specific aromatic alcohol is phenoxyethanol, and a specific lower alcohol is isopropanol.

[0016]

[0017] In another embodiment, the polyglycerol ester is (a) 2 to 12 based on the average value. The present invention provides a preservative composition comprising a polyglycerol component composed of glycerol molecules, and (b) a polyglycerol fatty acid ester derived from fatty acids including caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, cerotic acid, oleic acid, or decaoleic acid. Specific examples of such polyglyceryl fatty acid esters include one or more polyglyceryl-10 laurate, polyglyceryl-10 decaoleate; polyglyceryl-3 monostearate; polyglyceryl-6 distearate, polyglyceryl-10 stearate; polyglyceryl-10 oleate; polyglyceryl-10 dipalmitate; or polyglyceryl-10 caprylic / caprate.

[0017]

[0018] Another aspect of this disclosure relates to a method for increasing the efficacy of a preservative in a final-use formulation. To provide. This method includes steps of providing a preservative and an effective amount of a polyglycerol ester. Adding the preservative and the polyglycerol ester to the end-use formulation increases the efficacy of the preservative in the end-use formulation as compared to an equal amount of the preservative without the polyglycerol ester. The polyglycerol ester may be added to the preservative before the addition of the preservative to the end-use formulation, or after the preservative has been added to the end-use formulation, before the addition of the preservative to the end-use formulation, or simultaneously with the preservative to the end-use formulation. It includes steps. Adding the preservative and the polyglycerol ester to the end-use formulation increases the efficacy of the preservative in the end-use formulation as compared to an equal amount of the preservative without the polyglycerol ester. The polyglycerol ester may be added to the preservative before the addition of the preservative to the end-use formulation, or after the preservative has been added to the end-use formulation, before the addition of the preservative to the end-use formulation, or simultaneously with the preservative to the end-use formulation.

[0018]

[0019] In a further aspect of the present disclosure, a method of increasing the resistance of an end-use formulation to biological attack is provided. This method has steps of providing a cosmetic formulation and adding a preservative composition in any of the preceding aspects or embodiments to the cosmetic formulation. By adding the preservative composition, the end-use composition has increased resistance to biological attack as compared to an end-use formulation without the polyglycerol ester present in the preservative composition. It has steps. By adding the preservative composition, the end-use composition has increased resistance to biological attack as compared to an end-use formulation without the polyglycerol ester present in the preservative composition.

[0019]

[0020] In a further aspect of the present disclosure, a method of reducing the minimum amount of preservative required for effective preservative activity in an end-use formulation is provided. This method has steps of providing a preservative and adding an amount of a polyglycerol ester to the preservative to form a preservative composition. Next, the preservative composition is added to the end-use formulation, and the minimum amount of preservative required for effective preservative activity in the end-use formulation is less than when the preservative is used alone. It has steps. Next, the preservative composition is added to the end-use formulation, and the minimum amount of preservative required for effective preservative activity in the end-use formulation is less than when the preservative is used alone.

[0020]

[0021] In a further embodiment, an end-use formulation containing a preservative composition in any of the preceding embodiments is provided. The end-use formulation may be a personal care formulation or a home care formulation. The end-use formulation may be a personal care formulation or a home care formulation.

[0021]

[0022] These and other embodiments will become clear when reading the embodiments for carrying out the invention. Ro.

[0022]

[0023] [Modes for carrying out the invention]

[0023]

[0024] This discussion describes exemplary embodiments only and does not limit the broader aspects of this disclosure. Those skilled in the art should understand that this is not intended to be done.

[0024]

[0025] Generally, this disclosure relates to preservative compositions. Where used herein, the term "preservative composition" is used. "Preservative formulation" means a biocide or biocide composition intended to be blended into a final-use formulation, such as personal care formulations, cosmetics, home care formulations, and health and hygiene products, to prevent microorganisms from destroying the final-use formulation or making it impossible to use the final-use formulation for the specific purpose for which it was developed.

[0025]

[0026] Surprisingly, a certain amount of polyglycerol ester was used as a preservative for the final product. It has been found that adding the polyglycerol ester to the formulation can provide an effectively preserved end-use formulation with a synergistic interaction between the preservative and the polyglycerol ester. As used herein, “synergistic interaction” means that the preservative, when combined with the polyglycerol ester, has a greater overall antibacterial / antifungal effect than the preservative alone or the polyglycerol ester alone. In other words, the preservatives of this disclosure synergistically interact with the polyglycerol ester to have greater antibacterial / antifungal activity against specific microorganisms in their respective presences compared to the antibacterial activity of the preservative alone or the polyglycerol ester alone at the same concentration. It works. Due to a synergistic effect, the amount of preservative present in the preservative composition can be reduced while still producing the desired efficacy. This effect is also known as the "enhancement" of the preservative in the preservative composition. This enhancement of the preservative also, as used herein, refers to the "synergistic effect" between the preservative and the polyglycerol ester that enhances the efficacy of the preservative.

[0026]

[0027] As used herein, the term “its salt” means sodium, potassium, calcium It is intended to include cations of um, magnesium, ammonium, and ethanolamine, as well as other similar cations, anions of chlorine, bromine, acetate, and sulfate, and other similar anions.

[0027]

[0028] Suitable preservatives usable in this disclosure include, for example, acids, esters and their salts, and aluminum This includes aldehydes, phenol compounds, sulfites and iron chelating agents, aromatic alcohols, quaternary ammonium compounds, aldehydes, pyrone compounds, urea compounds, imidazole compounds, isothiazolinones, and combinations thereof.

[0028]

[0029] In one embodiment, the preservative is an acid compound containing both aromatic and non-aromatic acids. It may be present. Exemplary acids include, for example, benzoic acid, propionic acid, salicylic acid, sorbic acid, formic acid, undec-10-enoic acid, lactic acid, glycolic acid, and citric acid. In addition, salts of these acids, as well as esters of these acids, may also be used. Examples of salts include sodium benzoate and potassium sorbate. Other salts may also be used. Acid compounds are typically used as preservatives in the final formulation in amounts up to about 3% by weight, depending on the specific acid compound. Similar amounts may be used for esters and salts. In most cases where they are used, the amount of acid, its ester, or salt is up to about 1% by weight, more typically up to about 0.6% by weight. Mixtures of acids may also be used as preservatives.

[0029]

[0030] In another embodiment, the preservative may be an aldehyde. Exemplary aldehydes are These include, for example, formaldehyde and paraformaldehyde. Exemplary aldehyde-forming agents include imidazolidine compounds such as dimethyloldimethylhydantoin (DMDMH) and other similar aldehyde-forming hydantoins. Depending on the use, the aldehyde may be present in amounts up to 0.3% by weight in the preserved composition. Typically, the amount of aldehyde is up to 0.2% based on the weight of the preserved composition. Mixtures of aldehydes may also be used as preservatives.

[0030]

[0031] In further embodiments, the preservative may be a phenolic compound. Phenolic compounds include, for example, paraben compounds, biphenyl-2-ol (o-phenylphenol) or its salts, 4-chloro-m-cresol, 5-chloro-2-(2,4-dichlorophenoxy)phenol (triclosan), 4-chloro-3,5-dimethylphenol, 4-isopropyl-m-cresol, 2-benzyl-4-chlorophenol, and bromchlorophene. Exemplary paraben compounds include, for example, butylparaben, propylparaben, ethylparaben, methylparaben, and their salts, including, for example, potassium, sodium, and / or calcium salts. Phenolic compounds are typically used as preservatives in final-use formulations in amounts up to about 1% by weight, based on the total weight of the final-use formulation. This upper limit varies depending on the specific phenolic compound. More typically, phenolic compounds are used in cosmetic formulations in amounts up to about 0.5% by weight.

[0031]

[0032] In yet another embodiment, the preservative is a compound known as an iron chelating agent. This may also be done. Exemplary iron chelating agents include compounds such as pyrithione compounds and piroctone olamine or hydroxylpyridine compounds and their salts. Pyrithione is 2 It is known by several names, including mercaptopyridine-N-oxide; 2-pyridinethiol-1-oxide (CAS registry number 1121-31-9); 1-hydroxypyridine-2-thione and 1-hydroxy-2(1H)-pyridinethione (CAS registry number 1121-30-8); 2-pyridinol-1-oxide (HPNO), and N-hydroxy-6-octyloxypyridine 2(1H)-one and hydroxy-6-octyloxypyridine 2(1H)-one ethanolamine salt. Pyrithione salts, such as OMADINE sodium (registered trademark) or OMADINE zinc (registered trademark), are commercially available from Lonza.

[0032]

[0033] Pyrithione, present as a preservative, exists in either a water-insoluble or water-soluble form. Pyrithione may include sodium pyrithione, zinc pyrithione, barium pyrithione, strontium pyrithione, copper pyrithione, cadmium pyrithione, and / or zirconium pyrithione. Other pyrithiones that may be present in the composition include sodium pyrithione, bismuth pyrithione, potassium pyrithione, lithium pyrithione, ammonium pyrithione, calcium pyrithione, magnesium pyrithione, silver pyrithione, gold pyrithione, manganese pyrithione, and / or organic amine pyrithione. A single pyrithione may be present as a preservative, or any combination of the above may be included as a preservative.

[0033]

[0034] Pyrithione particles are 100% less than 10 micrometers (microns) in size. The particles may have a diameter such that at least 70% of them have a diameter of less than 5 micrometers, and at least about 50% of them have a diameter of 1 micrometer or less. The particle diameter can be measured using a laser scattering particle size analyzer, such as the HORIBA LA 910 particle size analyzer.

[0034]

[0035] Pyrithione particles are water-soluble salts of pyrithione or pyrithione, and water-soluble poly This can be produced by reacting valence metal salts in a pressurized circulating turbulent reactor that generates fine grinding force. The fine grinding force generated by the pressurized circulating turbulent reactor efficiently produces micrometer-sized pyrithione salt particles. The micrometer-sized pyrithione salt particles produced by this method have a narrow and uniform size distribution and excellent surface deposition properties due to the large surface area provided by the aggregation of micrometer particles.

[0035]

[0036] Iron chelating compounds typically contain up to about 1% by weight, depending on the specific compound. In small quantities, they are used as preservatives in the final formulation. Of particular interest are zinc pyrithione and piroctone olamine. These iron chelating agents may also have other advantages, including other benefits in formulations, such as anti-dandruff properties in hair care products.

[0036]

[0037] In another embodiment, the preservatives are inorganic sulfite compounds and bisulfite compounds. It may contain sulfite compounds. Sulfite compounds are generally present in amounts up to about 0.5% by weight, based on the total weight of the final formulation.

[0037]

[0038] Other preservatives available in this disclosure include alcohol compounds. Alcohols are low Lower alcohols may be quaternary alcohols or aromatic alcohols. Lower alcohols are typically selected from monofunctional low molecular weight alcohols, preferably methanol, ethanol, isopropanol, or butanol, which are alkanols having 1 to 4 carbon atoms, or combinations thereof. Substituted alcohols such as chlorobutanol may also be used. Particularly preferred lower alcohols include ethanol and isopropyl alcohol. Aromatic alcohols may also be used. Preferred aromatic alcohols include phenoxyethanol, 2,4-dichlorophenylmethanol, benzyl alcohol, 1-phenoxypropanol, chlorphenesin, and benzylhemiformal. Alcohol compounds are, Typically, depending on the specific alcohol compound, it is used as a preservative in the final formulation in amounts up to about 1.5% by weight, based on the total weight of the final formulation. In most cases, the amount of alcohol compound used is typically up to about 1% by weight, and more typically up to about 0.5% by weight, based on the weight of the final formulation.

[0038]

[0039] In another embodiment, a quaternary ammonium compound may be used as a preservative. Suitable quaternary ammonium compounds include, for example, cetrimonium bromide, cetrimonium chloride, raultrimonium bromide, raultrimonium chloride, steartrimonium bromide, and steartrimonium chloride, for example alkyl (C 12~22 ) Trimethylammonium bromide, alkyl (C 12~22 ) Includes trimethylammonium chloride compounds, or mixtures thereof, such as benzalkonium chloride, benzalkonium bromide, and benzalkonium saccharate, which are benzethonium compounds. Quaternary ammonium compounds are typically used as preservatives in the final-use formulation in amounts up to about 0.2% by weight, based on the total weight of the final-use formulation, depending on the specific quaternary ammonium compound. In most cases, the amount of quaternary ammonium compound used is typically up to about 0.1% by weight, more typically up to about 0.05% by weight, based on the weight of the final-use formulation.

[0039]

[0040] Exemplary pyrone compounds usable as preservatives in this disclosure include, for example, dehydrovinegar. This includes acids and their salts. Pyrone compounds may be used in amounts up to about 1.0% by weight based on the total weight of the cosmetic formulation. More typically, pyrone compounds may be used in amounts up to about 0.6% by weight.

[0040]

[0041] Examples of isothiazolinones usable as preservatives in this disclosure include, for example, 5-chloro This includes lo-2-methylisothiazolinone (chloromethylisothiazolinone), 2-methylisothiazolinone (methylisothiazolinone), benzisothiazolinone, and mixtures thereof. These compounds are typically used in amounts up to about 0.01% by weight of the final formulation.

[0041]

[0042] Exemplary urea compounds usable as preservatives in this disclosure include, for example, 3-(4-) This includes chlorophenyl)-1-(3,4-dichlorophenyl)urea (triclocarban); 1,1'-methylenebis{3-[4-(hydroxymethyl)-2,5-dioxoimidazolidine-4-yl]urea}; and N-(hydroxymethyl)-N-(dihydroxymethyl-1,3-dioxo2,5-imidazolinidyl-4)-N'-(hydroxymethyl)urea. These compounds are typically used in amounts up to about 0.5% by weight of the final formulation.

[0042]

[0043] Examples of imidazole compounds usable as preservatives in this disclosure include, for example, 1- This includes (4-chlorophenoxy)-1-(imidazole-1-yl)-3,3-dimethylbutan-2-one); and 1,3-bis(hydroxymethyl)-5,5-dimethylimidazolidine-2,4-dione). These compounds are typically used in amounts up to about 0.5% by weight of the final formulation.

[0043]

[0044] Other ingredients that can be used as preservatives include dibromohexaamidine and its salts; Thiomersal; phenyl mercury salt; hexetidine; 2-bromo-2-nitropropane-1,3-diol; 5-bromo-5-nitro-1,3-dioxane; polyhexamethylene biguanide or its salts; hexamethylenetetramine; methenamine 3-chloroallyl ochloride; 2-chloroacetamide; chlorohexidine and its digluconate, or its diacetate and dihydrochloride; 4,4-dimethyl,1,3-oxazolidine; glutaraldehyde; 5-ethyl-3,7-dioxa-1-azabicyclooctane; hi It contains sodium droxymethylglycine, 3-iodo-2-propynyl butylcarbamate (IPBC), and ethyl lauroyl alginate. These compounds are typically used in amounts up to about 0.5% by weight of the final formulation.

[0044]

[0045] In addition, preservatives include single preservatives and two or more preservatives derived from a single type of preservative. It may be a mixture of the above, or a mixture of two or more different types of preservatives.

[0045]

[0046] In one embodiment, the polyglycerol esters usable in this disclosure are saturated, unsaturated, etc. They can be formed from natural or synthetic fatty acids, for example. Saturated fatty acids include caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, cerotic acid, combinations thereof, and derivatives thereof. Furthermore, polyglycerol esters are derived from (a) polyglycerol components consisting of 2 to 12 glycerol molecules based on average values, and (b) fatty acids selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, cerotic acid, oleic acid, decaoleic acid, and mixtures thereof.

[0046]

[0047] Examples of polyglycerol esters usable in this disclosure include poly monodecaoleate. Glyceryl, e.g., polyglyceryl-10 decaoleate; polyglyceryl monooleate, e.g., polyglyceryl-2 monooleate, polyglyceryl-3 monooleate, polyglyceryl-4 monooleate, polyglyceryl-6 monooleate, or polyglyceryl-10 monooleate; polyglyceryl dioleate, e.g., polyglyceryl-2 dioleate, polyglyceryl-3 dioleate, polyglyceryl-5 dioleate, polyglyceryl-6 dioleate, or polyglyceryl-10 dioleate; polyglyceryl trioleate Polyglyceryl trioleate, for example, polyglyceryl-5 or polyglyceryl-10 trioleate; polyglyceryl tetraoleate, for example, polyglyceryl-2, polyglyceryl-6, or polyglyceryl-10 tetraoleate; polyglyceryl pentaoleate, for example, polyglyceryl-4, polyglyceryl-6, or polyglyceryl-10 pentaoleate; polyglyceryl heptaolate, for example, polyglyceryl-6, polyglyceryl heptaolate -10; Polyglyceryl monostearate, e.g., polyglyceryl-2 monostearate, polyglyceryl-3 monostearate, polyglyceryl-4 monostearate, polyglyceryl-5 monostearate, polyglyceryl-6 monostearate or polyglyceryl-10 monostearate; Polyglyceryl distearate, e.g., polyglyceryl-2 distearate, polyglyceryl-3 distearate, polyglyceryl-4 distearate, polyglyceryl-6 distearate or polyglyceryl-10 distearate; Tristearin Polyglyceryl acids, e.g., polyglyceryl-4 tristearate, polyglyceryl-5 tristearate, polyglyceryl-6 tristearate, or polyglyceryl-10 tristearate; polyglyceryl tetrastearate, e.g., polyglyceryl-2 tetrastearate; polyglyceryl pentastearate, e.g., polyglyceryl-4 pentastearate, polyglyceryl-6 pentastearate, or polyglyceryl-10 pentastearate; polyglyceryl heptastearate, e.g., polyglyceryl-10 heptastearate;Polyglyceryl isostearate, e.g., polyglyceryl-2 isostearate, polyglyceryl-3 isostearate, polyglyceryl-4 isostearate, polyglyceryl-6 isostearate, or polyglyceryl-10 isostearate; polyglyceryl diisostearate, e.g., polyglyceryl-2 diisostearate, polyglyceryl-3 diisostearate, polyglyceryl-4 diisostearate, polyglyceryl-6 diisostearate, polyglyceryl-10 diisostearate, or polyglyceryl- 15; Polyglyceryl triisostearate, e.g., polyglyceryl-2 triisostearate, polyglyceryl-3 triisostearate, polyglyceryl-5 triisostearate, polyglyceryl-10 triisostearate; Polyglyceryl tetraisostearate, e.g., polyglyceryl-2 tetraisostearate; Polyglyceryl caprylate, e.g., polyglyceryl-2 caprylate, polyglyceryl-3 caprylate, polyglyceryl-4 caprylate, polyglyceryl-6 caprylate, or caprylic Polyglyceryl-10; Polyglyceryl dicaprylate, e.g., Polyglyceryl-5 dicaprylate; Polyglyceryl sesquicaprylate, e.g., Polyglyceryl-2 sesquicaprylate; Polyglyceryl octacaprylate, e.g., Polyglyceryl-6 octacaprylate; Polyglyceryl caprate, e.g., Polyglyceryl-2 caprate, Polyglyceryl-3 caprate, Polyglyceryl-4 caprate, Polyglyceryl-5 caprate, Polyglyceryl-6 caprate, Polyglyceryl-10 caprate, Dicaprine Polyglyceryl acids, e.g., polyglyceryl-3 dicaprate or polyglyceryl-6 dicaprate; polyglyceryl caprylate / caprate, e.g., polyglyceryl-4 caprylate / caprate, polyglyceryl-6 caprylate / caprate, or polyglyceryl-10 caprylate / caprate; polyglyceryl palmitate, e.g., polyglyceryl-2 palmitate, polyglyceryl-3 palmitate, polyglyceryl-6 palmitate, or polyglyceryl-10 palmitate; polyglyceryl dipalmitate This includes, but is not limited to, lyl, e.g., polyglyceryl-6 dipalmitate or polyglyceryl-10 dipalmitate; polyglyceryl tetrabehenate, e.g., polyglyceryl-6 tetrabehenate; polyglyceryl myristate, e.g., polyglyceryl-6 myristate or polyglyceryl-10 myristate; polyglyceryl phosphate-cinoleate, e.g., polyglyceryl-6 polyphosphate-cinoleate or polyglyceryl-10 phosphate-cinoleate; or mixtures thereof, other complexes or derivatives thereof.

[0047]

[0048] Preferably, the polyglycerol ester is one or more polydecaoleates. The polyglyceryl-10 may be polyglyceryl-3 monostearate, polyglyceryl-6 distearate, polyglyceryl-10 stearate, polyglyceryl-10 oleate, polyglyceryl-10 dipalmitate, polyglyceryl-10 caprylic / caprate, or mixtures thereof. In one embodiment, the polyglycerol ester is polyglyceryl-10 caprylic / caprate.

[0048]

[0049] This disclosure specifies the weight ratio of polyglycerol ester (PGE) to preservative (PA). The weight ratio is typically in the range of about 0.00001 to about 10.0 (PGE / PA). As used herein, “weight ratio” is calculated by dividing the amount of polyglycerol ester by the amount of preservative (for example, a weight ratio of 10 is the same as 10 PGE:1 PA). More typically, the weight ratio of polyglycerol ester (PGE) to preservative (PA) is typically in the range of about 0.0001 to about 2.0, more typically 0.001 to 1.5, and even more specifically 0.01 to 1.0. The weight ratio of PGE to PA may be any amount between the minimum and maximum values. For example, the ratio may be between 0.00001~2.0;0.0001~1.5;0.00001~1;0.00001~0.5;0.0001~10;0.0001~1.5;0.0001~1;0.0001~0.5;0.001~10;0.001~1.5;0.001~1;0.001~0.5;0.01~10;0.01~1.5;0.01~1;0.01~0.5.

[0049]

[0050] The amount of preservatives used in the final formulation of this disclosure is, as stated above, a specific preservative. It varies depending on the preservative. In alternative embodiments, the preservative may be formulated in the form of a preservative concentrate. "Preservative concentrate" or "preservative composition" means a composition that is added to the final-use formulation in a specified amount. In a preservative concentrate, the amount of preservative is greater than the typical final-use amount. The preservative concentrate contains only the preservative and polyglycerol ester. Alternatively, the preservative concentrate may contain a preservative, a polyglycerol ester, and a carrier compatible with the final-use formulation. An example of a carrier is, for instance, water as the aqueous solvent, or other solvents permissible for use with the final-use formulation. Typically, the preservative concentrate is added to the final-use formulation in the amount necessary to achieve the desired amount of preservative formulation in the final final-use formulation.

[0051] When contained in preservative concentrates, preservatives and polyglycerol esters are... It may be combined with various different components. For example, in one embodiment, a solvent may be present in the product. Generally, the solvent is a polar solvent such as water, or a water-miscible solvent such as alcohol and / or glycol ether. In addition to water, the antimicrobial composition may further contain a water-miscible organic solvent. Examples of water-miscible solvents include ethanol, propanol, benzyl alcohol, isopropanol, diethylene glycol propyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-butyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, propylene glycol n-butyl ether, tripylene glycol methyl ether, dipropylene glycol methyl ether, dipropylene glycol butyl ether, and combinations thereof.

[0050]

[0052] In other embodiments, the polyglycerol ester and the preservative are used independently of each other. It may be added to the final product. That is, the polyglycerol ester may be added to the preservative before the preservative is added to the final product, or after the preservative has been added to the final product, before the preservative is added to the final product, or simultaneously with the preservative as a separate ingredient.

[0051]

[0053] Various different microorganisms can be controlled by this disclosure. For example, the preservatives of this disclosure The antiseptic composition can control Gram-positive bacteria, Gram-negative bacteria, and the like. In addition to bacteria, the antiseptic composition of this disclosure can also kill and control the growth of various other microorganisms such as viruses, spores, and mycobacteria. Examples of specific microorganisms that may be controlled by the present disclosure are Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Serratia marcescens, Salmonella enteritidis, Neisseria gonorrhoeae, Escherichia coli, Enterococcus hirae, Acinetobacter baumannii, Listeria monocytogenes, Enterobacter gergoviae, Klebsiella pneumoniae, Burholderia cepacia, Pseudomonas putida, Kocuria rhizophila, Candida albicans, Saccharomyces cerevisiae, Aspergillus brasiliensis, Penicillium funiculosum, Eupenicillium levitum, Bacillus cereus, Bacillus subtilis, Clostridium difficile, Clostridium perfringens, Mycobacterium This includes tuberculosis, Mycobacterium terrae, Mycobacterium avium, Poliovirus, Adenovirus, Norovirus, Vaccinia virus, influenza virus, Hepatitis B virus, Human Immunodeficiency virus, Human papillomavirus, or mixtures thereof.

[0052]

[0054] In general, the preservative compositions of this disclosure can be used in any many different end-use formulations or manufacturing processes. It may be incorporated into the product. As used herein, “final use formulation” or “final use product” is intended to mean personal care products, including cosmetics, home care products, and health and hygiene products. For example, personal care products may include cosmetic formulations such as face creams, makeup removers, mascaras, or wet wipes. Personal care product formulations may also include liquids for personal care wet wipe applications such as shampoos, conditioners, skin lotions, or wet wipes. Personal care product formulations may also include products for topical application to the user's skin or hair. When combined with personal care product formulations as a preservative, the composition has broad-spectrum preservative activity that is effective over a wide pH range. For example, the pH of the composition and / or personal care product may generally be greater than about 2 and less than about 9, e.g., about 3 to about 8, and more specifically, about 3 to about 6.

[0053]

[0055] The preservative composition is used in handwashing soap, dish soap, laundry detergent, cleaning wipes, and general-purpose creams. It can also be incorporated into home care products such as ointments and other similar formulations used around the home.

[0054]

[0056] Personal care product formulations generally have the preservative composition of this disclosure added to the base. The base formulation may contain many different ingredients depending on the end use. Personal care product formulations may contain, for example, solvents, surfactants, emulsifiers, consistency elements, conditioning agents, emollients, skin care ingredients, moisturizers, thickeners, water-retaining agents, fillers, antioxidants, other preservatives, active ingredients, in particular dermatologically active ingredients, fragrances, and mixtures thereof. Active ingredients referred to herein include, for example, agents such as anti-inflammatory agents, antibacterial agents, and antifungal agents. Active ingredients suitable for topical application are particularly preferred.

[0055]

[0057] Suitable surfactants include alkyl sulfates, such as sodium lauryl sulfate and lauryl sulfate. This includes ammonium sulfate; sodium cetearyl sulfate; alkyl sulfoacetates, e.g., sodium lauryl sulfoacetate; alkyl ether sulfates, e.g., sodium laureth sulfate; sodium trideceth sulfate; sodium oleth sulfate; ammonium laureth sulfate; alkyl ether sulfosuccinates, e.g., disodium laureth sulfosuccinate; alkyl glycosides, e.g., decyl glucoside; lauryl glucoside; amphoteric alkyl isethionates, e.g., cocamidopropyl betaine; sodium cocoamphoacetate; sodium lauroamphoacetate; disodium lauroamphodiacetate; disodium cocoamphodiacetate; sodium lauroamphopropionate; disodium lauroamphodipropionate; potassium or ammonium salts of the aforementioned amphoteric substances; capryl / capraamidopropyl betaine; undecylenamidopropyl betaine; lauromidopropyl betaine; and fatty alcohol polyglycol ethers.

[0056]

[0058] Suitable emulsifiers include, for example, anionic substances and fatty acid salts, such as stearin. Sodium sulfate or sodium palmitate, organic soaps, e.g., mono-, di- or triethanolaminoates, sulfated or sulfonated compounds, e.g., sodium lauryl sulfate or sodium cetyl sulfonate, saponins, lamepones; cationic substances, as quaternary ammonium salts; nonionic substances, as fatty alcohols, fatty acid esters with saturated or unsaturated fatty acids, polyoxyethylene esters or polyoxyethylene ethers of fatty acids, polymers from ethylene oxide and propylene oxide or propylene glycol, amphoteric substances, as phosphatides, proteins such as gelatin and casein, alkylamide betaines, alkyl betaines and amphoglycinates, alkyl phosphates, polyoxyethylene alkyl phosphates or corresponding The acid is a silicone derivative, such as an alkyl dimethicone copolyol.

[0057]

[0059] Suitable consistency elements include, for example, fatty alcohols or their fatty acid esters. Mixtures with , for example, acetylated lanolin alcohol, aluminum stearate, carbomer, cetyl alcohol, glyceryl oleate, glyceryl stearate, glyceryl stearate (and) PEG-100 stearate, magnesium stearate, magnesium sulfate, oleic acid, stearic acid, stearyl alcohol, myristyl myristate, isopropyl palmitate, beeswax and synthetic equivalents thereof, carbomer, etc. Suitable conditioning agents include, for example, ammonium alkylamide lactate, cetrimonium chloride and distearoylethyl hydroxyethylmonium methosulfate and cetearyl alcohol, cetyl dimethicone, cetyl ricinoleate, dimethicone, laureth-23, laureth-4, polydecene, retinyl palmitate, quaternized protein hydrolysates, quaternized cellulose and starch derivatives, quaternized copolymers of acrylic acid or methacrylic acid or salts, and quaternized silicone derivatives.

[0058]

[0060] Suitable emollients include, for example, cetearyl isononanoate and cetearyl octanoate. L, Decyl Oleate, Isooctyl Stearate, Caprylic / Capric Coconut Oil, Ethylhexyl Hydroxystearate, Ethylhexyl Isononanoate, Isopropyl Isostearate, Isopropyl Myristate, Oleyl Oleate, Hexyl Laurate, Mineral Oil, PEG-75 Lanolin, PEG-7 Glyceryl Cocoate, Petrolatum, Ozokerite Cyclomethicone, Dimethicone, Dimethicone Copolyol, Dicaprylyl Ether, Butyrospermum Parkii, Buxus Chinensis, Canola, Carnauba Cera, Copernicia Cerifera, Oenothera Biennis, Elaeis Guineensis, Prunus Dulcis, Squalane, Zea Mays, Glycine Soja, Helianthus The ingredients are annuus, lanolin, hydrogenated castor oil, hydrogenated coconut oil, hydrogenated polyisobutene, sucrose cocoate, stearoxydimethicone, lanolin alcohol, and isohexadecane.

[0059]

[0061] Suitable skincare ingredients include, for example, plant extracts, bisabolol, anti-inflammatory agents, urea, These include allantoin, panthenol and panthenol derivatives, phytantriol, vitamins A, E, C, and D, animal or plant-derived ceramides, lecithin, and others.

[0060]

[0062] Suitable humectants include, for example, butylene glycol, cetyl alcohol, dimethicone, The ingredients are dimyristyl tartrate, glucose glycereth-26, glycerin, glyceryl stearate, hydrolyzed milk protein, lactic acid, lactose and other sugars, laureth-8, lecithin, octoxyglycerin, PEG-12, PEG-135, PEG-150, PEG-20, PEG-8, pentylene glycol, hexylene glycol, phytantriol, polyquaternium-39, PPG-20 methyl glucose ether, propylene glycol, sodium hyaluronate, sodium lactate, sodium PCA, sorbitol, succinoglycan, synthetic beeswax, tri-C14-15 alkyl citrate, and starch.

[0061]

[0063] Suitable thickeners include, for example, acrylate / steareth-20 methacrylate copolymer. These are mer, carbomer, carboxymethyl starch, beeswax, dimethicone / vinyl dimethicone crosspolymer, propylene glycol alginate, hydroxyethylcellulose, hydroxypropyl methylcellulose, silica, silica dimethyl silylate, xanthan gum, and hydrogenated butylene / ethylene / styrene copolymer.

[0062]

[0064] Suitable water-retaining agents include, for example, adipic acid, fumaric acid and its salts, benzoic acid and so Salt of glycerol triacetic acid, sodium lauryl sulfate or magnesium lauryl sulfate, These include magnesium thearate, solid polyethylene glycol, polyvinylpyrrolidone, boric acid, mono-laurate or mono-palmitate, myristyl alcohol, cetyl alcohol, cetyl stearyl alcohol, talcum, calcium or magnesium salts of higher fatty acids, mono-, di- or triglycerides of higher fatty acids, and polytetrafluorethylene.

[0063]

[0065] Suitable antioxidants include, for example, sulfites, such as sodium sulfite and tocopherol. Examples include ethyl alcohol or its derivatives, ascorbic acid or its derivatives, citric acid, propyl gallate, chitosan glycolic acid, cysteine, N-acetylcysteine ​​plus zinc sulfate, thiosulfates, such as sodium thiosulfate, and polyphenols.

[0064]

[0066] The formulation contains active ingredients such as antibacterial agents, anti-inflammatory agents, plant extracts, bisabolol, and It may further contain anthenol, tocopherol, active substances for anti-stinging, anti-irritation, or anti-dandruff purposes, or anti-aging agents such as retinol and melibiose. Other suitable active ingredients include, for example, Medicago officinalis, Actinidia chinensis, allantoin, Aloe barbadensis, Anona cherimolia, Anthemis nobilis, Arachis hypogaea, Arnica Montana, Avena sativa, beta-carotene, bisabolol, Borago officinalis, butylene glycol, Calendula officinalis, Camellia sinensis, camphor, Candida bombicola, capryloyl glycine, Carica papaya, Centaurea cyanus, cetylpyridinium chloride, Chamomilla recutita, Chenopodium quinoa, Chinchona succirubra, Chondrus crispus, orange peel oil, Citrus grandis, Citrus limonum, Cocos nucifera, Coffea Arabica, Crataegus monogina, Cucumis Melo, Dichlorophenylimidazol dioxolane, Enteromorpha compressa, Equisetum arvense, Ethoxydiglycol, Ethyl panthenol, Farnesol, Ferulic acid, Fragaria chiloensis, Gentiana lutea, Ginkgo biloba, Glycerin, Glyceryl laurate, Glycyrrhiza glabra, Hamamelis virginiana, Heliotropin, Hydrogenated palm glycerides, Citrate, Hydrogenated castor oil, Hydrolyzed wheat protein, Hypericum perforatum, Iris florentina, Juniperus communis, Milk protein, Lactose, Lawsonia inermis, Linalool, Linum usitatissimum, Lysine, Magnesium aspartate, Magnifera indica, MalvaSylvestris, mannitol, Melaleuca alternifolia, Mentha piperita, menthol, menthyl lactate, Mimosa tenuiflora, Nymphaea alba, olaflour, Oryza sativa, panthenol, mineral oil, PEG-20M, PEG-26 jojoba fatty acid, PEG-26 jojoba alcohol, PEG-35 castor oil, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-8 caprylic / capric acid, avocado oil, petrolatum, potassium aspartate, potassium sorbate, propylene glycol, Prunus amygdalus dulcis, Prunus armeniaca, Prunus persica, retinyl palmitate, Ricinus communis, Rosa canina, Rosmarinus officinalis, Rubus idaeus, salicylic acid, Sambucus Nigra, sarcosine, Serenoa serrulata, Simmondsia chinensis, sodium carboxymethyl beta-glucan, sodium cocoyl amino acid, sodium hyaluronate, sodium palmitoyl praline, stearoxytrimethylsilane These are stearyl alcohol, TEA-ricinoleic acid sulfide, talc, Thymus vulgaris, Tilia cordata, tocopherol, tocopheryl acetate, trideceth-9, triticum vulgare, tyrosine, undecylenoylglycine, urea, Vaccinium myrtillus, valine, zinc oxide, and zinc sulfate.

[0065]

[0067] The preservative compositions disclosed herein are emulsions (both oil-in-water and water-in-oil), It can be used in aqueous solutions, PIT (phase inversion temperature) emulsions, oily solutions, foaming cosmetic formulations (foams), and so-called complex emulsions, such as three-phase emulsions (water / oil / water emulsions, etc.).

[0066]

[0068] The preservative compositions of this disclosure may also be used as creams, gels, liquids, or lotions. It may be used in formulations such as hair care products, e.g., shampoos, hair conditioners, hair dyes, hair growth products, hair gels, hair styling products, hair styling aids and other hair care preparations; shaving applications, e.g., shaving creams, aftershave lotions and other shaving applications; personal cleaners for the body and hands, e.g., liquid bath soaps and detergents; fragrance preparations, e.g., perfumes, after-bath splashes and other similar fragrance preparations; skin care products, e.g., moisturizers, creams and lotions and other similar skin care products; makeup products, e.g., mascara, foundation primers and other similar products; makeup removal products, e.g., sun protection products, indoor tanning products and other similar personal care products. One specific use of this preservative composition as a preservative formulation for formulations is for use in personal cleaning and hygiene (e.g., baby wipes, wet toilet wipes, makeup removal wipes and peeling wipes). Preservative compositions can also be used in other formulations where preservatives are required.

[0067]

[0069] Typically, the preservative compositions of this disclosure contain the following in the final-use formulation to be stored: It can be added in amounts ranging from 0.01% to approximately 10% by weight. More specifically, the preservative composition is added in an amount of approximately 0.1% to 5.0% by weight of the formulation. The amount of preservative composition added depends on the selected preservative.

[0068]

[0070] The preservative composition is also used to ensure that it is thoroughly absorbed into the wet wipes. It can be used in wet wipe formulations. The preservative composition helps preserve the wet wipe formulation and wipes before use. Once the wet wipe composition is formulated, it is applied to the substrate.

[0069]

[0071] A wet wipe composition containing a preservative composition is made using conventional application techniques. It can be applied to a substrate to be processed. Conventional techniques include spraying, injecting, spraying and / or wiping the formulation onto the substrate. The composition is provided to the end user as a ready-to-use formulation or in a container with application means. For example, the composition may be provided as a compressed aerosol in a container, in a container having a trigger or spray pump, in a conventional container having a dispensing container or a removable cap so that the user can pour the formulation onto the substrate.

[0070]

[0072] However, one particularly useful application method is to impregnate the wiper substrate with the compound. The objective is to allow the user to take out individual wipes. In this embodiment, the wipes are single-use wipes impregnated with a formulation and stored in a container from which the user can take out individual wipes. The container having the wipes may contain a single wipe or multiple wipes. A preferred container may include a pouch containing a single wipe, such as a moist towel, which is opened by the user, or a pouch having a resealable opening which is stacked to allow a single wipe to be taken out from the opening at once, or several wipes in another preferred form. Contains. Pouches are generally made from liquid-impermeable materials such as film, coated paper, or foil, or other similar liquid-impermeable materials. Another method for separating and removing the wipes of the present invention is to place the wipes in a liquid-impermeable container having an opening that allows the user to reach the wipes in the container. The container may be a molded plastic container with a liquid-impermeable lid. Generally, the lid has an opening that allows the user to reach the wipes in the container. The wipes in the container may be stacked alternately so that when one wipe is removed from the container, the user can take out the next wipe, and the next wipe is positioned at the opening of the container. Alternatively, the wipes may be made from a continuous material with perforations between the individual wipes of the continuous material. Perforated continuous wipe material may be in a folded form or in a roll form. Generally, in the roll form, the wipe material is supplied from the center of the roll material. Because they are stacked alternately, when one wipe is removed from the container, the next wipe is positioned at the opening for use, allowing you to take out the next wipe if needed.

[0071]

[0073] Disposable wipes have advantages over other application media such as reusable sponges and rugs. Unlike sponges, rugs, etc., which are used repeatedly, impregnated wipes are used once and then discarded.

[0072]

[0074] The wipe is pre-moistened, and as the wipe moves around on the substrate to be treated, the mixture is transferred to the substrate. The formulation is impregnated into the wipe so that it appears or is released onto the surface. Generally, the formulation is thoroughly absorbed into the wipe so that, through the wiping motion, the wipe releases the formulation onto the substrate.

[0073]

[0075] Suitable wipe substrates include woven and nonwoven materials. Essentially, any nonwoven wipe Nonwoven materials may be used. Exemplary nonwoven materials may include, but are not limited to, hot-blown, coform, spunbond, airlaid, airlaced, water-entangled nonwovens, spunlace, bonded carded webs, and laminates thereof. The fibers used to produce the wipe substrate may be cellulosic fibers, thermoplastic fibers, and mixtures thereof. The fibers may also be continuous fibers, discontinuous fibers, short fibers, and mixtures thereof. The basis weight of the nonwoven web may vary from about 12 grams per square meter to 200 grams per square meter (gsm) or more.

[0074]

[0076] In one embodiment, the substrate impregnated with the wipe composition contains a significant amount of cellulose fiber. It contains fibers. More specifically, the wipe compositions of this disclosure are particularly suitable for protecting cellulose substrates from attack by microorganisms that may contaminate products. In a particular embodiment, for example, the substrate may be made from cellulosic fibers in amounts such as over 80% by weight, over 85% by weight, over 90% by weight, over 95% by weight, or even 100% by weight. For example, in one embodiment, the substrate is made from pulp fibers and a binder in an air-race process. The basis weight of the substrate may be about 20 gsm to about 100 gsm, about 40 gsm to about 70 gsm, about 50 gsm to about 60 gsm, etc.

[0075]

[0077] Once incorporated into the substrate, the resulting wipe product has a ratio of approximately 5:1 to approximately 1:1. For example, the weight ratio of the liquid to the substrate may be approximately 2:1 to 4:1.

[0076]

[0078] The following examples illustrate the present invention without limiting it. All parts and Percentages are given in weight unless otherwise specified.

[0077]

[0079] Each of the elements described in the following examples, or two or more elements together, It will be understood that useful applications can be found in other types of methods different from those described above. Without further analysis, the foregoing fully illustrates the intent of this disclosure. Therefore, by applying current knowledge, it will be possible to easily adapt the disclosure to various uses without omitting features that clearly constitute the essential features of the general or specific aspects of the disclosure as expressed in the attached claims, from the perspective of the prior art.

[0078]

[0080] [Examples]

[0079]

[0081] To demonstrate the synergistic effect, the following examples were implemented.

[0080]

[0082] Preparation of test organisms

[0083] The target organism is Pseudomonas aeruginosa ATCC Cell 15442 was removed from the freezer and grown on tryptone soy agar (TSA) at 37°C for 24 hours. A second subculture was generated from the first and grown under the same conditions. Next, a test suspension was prepared by adding one loopful of the organism to tryptone-buffered saline, and the cell concentration was measured using an internally established calibration curve spectrophotometer at a wavelength of 600 nm to determine the cell concentration at 1 × 10⁻⁶. 8 and 5×10 8 The concentration was adjusted to CFU / ml. To establish the exact CFU / ml, a 1 ml aliquot was then taken from the test suspension and 10 -6 and 10 -7 The solution was sequentially diluted, and then 1 ml of each dilution was repeatedly plated onto TSA using the pour plate method (in duplicate). The plates were then incubated at 37°C for 24 hours and counted.

[0081]

[0084] Preparation of test samples

[0085] For each active ingredient to be tested, a series of three samples were prepared in sterile distilled water;

[0086] Test sample 1 - Active ingredient alone (to measure the basic efficacy of the active ingredient)

[0087] Activity when combined with test sample 2-caprylic acid / polyglyceryl-10 caprate Ingredients (to measure the efficacy of the combination of active ingredients and polyglycerol esters)

[0088] Control - Caprylic / Capric Polyglyceryl-10 control sample, deionized water The preparations were made in the environment, and the efficacy of the polyglycerol ester alone was measured.

[0082]

[0089] Considering the dilution effect from the addition of the test organism suspension during the test procedure, each test sample The solution was prepared at a concentration 10% higher than the target concentration.

[0083]

[0090] Test Procedure

[0091] Place a 0.1 ml aliquot of the test organism suspension into a tube, followed by 0.9 ml Test mixtures were prepared by adding the test samples (prepared as described above). Next, these combinations were mixed, and the timer was started immediately. Each test mixture was allowed to stand for the specified contact time shown in Table 1.

[0084]

[0092]

[0085] [Table 1]

[0086]

[0093] When the specified contact time is reached, 0.1 ml aliquots of the test mixture are added to 0.9 ml The test mixture was deactivated by adding it to a neutralized culture medium and mixing the entire solution. This solution was left to stand for 5 minutes to confirm that the action of the active ingredient had been effectively neutralized.

[0087]

[0094] To quantify the number of organisms remaining in the neutralized test mixture, 4 × 0.025 ml aliquots were taken and spot-plated onto the surface of dry TSA. The plate was then incubated at 37°C for 24 hours.

[0088]

[0095] Counting and calculation of logarithmic decrease

[0096] Limit of Detection (LOD)

[0097] Depending on the dilution parameters of the methods and techniques used to count cells, To ensure reliable counts, specific detection limits must be established.

[0089]

[0098] Regarding the counting of pour plates, the lower limit of counting is <10 and the lower limit is >330. The colonies from the incubated plate were counted using a count limit. For example, if a plate has 7 visible colonies that can be counted, <10 is recorded and 10 is used in the calculation. Regarding the limit, if 407 colonies are counted on the plate, >330 is recorded and 330 is used in the calculation.

[0090]

[0099] Regarding spot plating, the count limit is <1 and the count limit is >150. The upper limit was used to count the colonies from the incubated plate. For example, if a plate has 0 visible colonies, <1 is recorded and 1 is used in the calculation. Regarding the upper limit, if 156 colonies are counted on the plate, >150 is recorded and 150 is used in the calculation.

[0091]

[0100] When reporting the final logarithmic decline, use a lower detection limit for calculation. In this case, a ">" value, e.g., ">5.02 logarithmic decrease", is reported, while if a higher detection limit is used to calculate it, a "<" value, e.g., ">2.92 logarithmic decrease", is reported.

[0092]

[0101] Counting and calculation of N (test organism suspension) and N0

[0093]

Number

[0094] In the formula, C is the total survival count value, n1 is the number of survival count values for the lower dilution, i.e., 10 -6 and is the number of survival count values related to it, n2 is the number of survival count values for the higher dilution, i.e., 10 -7 and is the number of survival count values related to it, 10 -6 is the dilution ratio corresponding to the lower dilution, For example:

[0095]

Number

[0096] N0 is the number of cells per milliliter in the test mixture at the start of the contact time. N0 is one-tenth of the weighted average of N due to a 10-fold dilution caused by the addition of the test product. Thus, in this example, N0 is 1.9×10 7 cfu / ml.

[0097]

[0102] Counting and calculation of T (test mixture) First, the mean average of cfu per 0.025 ml spot was determined using the following calculation;

[0098]

Number

[0099] In the formula, d1 is the total survival count value from 4 spots, Example:

[0100] [[ID=6Next, this was multiplied by 40 to determine the cfu / ml; example; T = 29.5 × 40 = 1180 cfu / ml During the neutralization step, the test mixture underwent a 10-fold dilution. Taking this into consideration, a 10-fold multiplication factor is ultimately applied; T = 1180 × 10 = 11800 = 1.18 × 10 4 cfu / ml Calculation of logarithmic decrease (N 0- T) Before calculating the logarithmic decrease, both N0 and T were converted to logarithmic values ​​of base 10. For example; N0 = 1.9 × 10 7 =7.28log10 T = 1.18 × 10 4 =4.07log10 The following formula was used to calculate the final logarithmic decrease; N0-T = Logarithmic decrease for example; 7.28 - 4.07 = 3.21 The final logarithmic decrease for this example is 3.21.

[0102]

[0103] Example 1

[0104] Using the test procedure outlined above, polyglyceryl-1 caprylate / caprate The synergistic effects between PG10CC and the various active ingredients listed in Table 1 were tested. Caprylic / capric polyglycerylglyceryl-10 showed little to no activity at 125 ppm, as reported in Table 2 below. Preparations were made at varying concentrations and tested for the presence of Pseudomonas aeruginosa at the times listed in Table 1. Table 2 below shows the amounts of biocidal raw materials and PG10CC at which initial signs of synergistic action between the biocide and PG10CC were observed. The calculated logarithmic decrease is for Pseudomonas aeruginosa and is shown in Table 2 for various mixtures.

[0105]

[0103] [Table 2]

[0104]

[0106] The present invention is described above with reference to specific embodiments thereof, but is not disclosed herein. It is clear that many changes, modifications, and variations can be made without departing from the inventive concept. Therefore, it is intended to encompass all such changes, modifications, and variations, which fall within the spirit and broad scope of the attached claims. The following is a description of the claims as they were at the time of filing the application. [Claim 1] (i) Preservatives comprising acid compounds, phenolic compounds, sulfites, iron chelating agents, aromatic alcohols, quaternary ammonium compounds, pyrone compounds, urea compounds, imidazole compounds, isothiazolinone compounds, or combinations of two or more preservatives; and (ii) A polyglycerol ester present in an amount that sufficiently increases the efficacy of the preservative compared to the preservative alone, and the amount of increase is greater than the additive effect of the biocidal activity of the preservative and the polyglycerol ester used alone. Includes, A preservative composition in which the weight ratio of the polyglycerol ester to the preservative is in the range of 0.0001 to 2.0. [Claim 2] The preservative composition according to claim 1, wherein the weight ratio of the polyglycerol ester to the preservative is in the range of 0.001 to 1.5, for example, in the range of 0.01 to 1.0. [Claim 3] The preservative composition according to claim 1, wherein the preservative comprises an iron chelating agent, and the iron chelating agent comprises a pyrithione compound such as zinc pyrithione, sodium pyrithione or a mixture thereof, piroctone olamine, 2-pyridinol-1-oxide, N-hydroxy-6-octyloxypyridine 2(1H)-one, N-hydroxy-6-octyloxypyridine 2(1H)-one ethanolamine salt or a mixture thereof. [Claim 4] The preservative composition according to claim 1, wherein the preservative is an acid compound such as an acid, an ester of an acid, or a salt of an acid. [Claim 5] The preservative composition according to claim 4, wherein the acid compound comprises benzoic acid, propionic acid, salicylic acid, sorbic acid, formic acid, undeca-10-enoic acid, lactic acid, glycolic acid, and citric acid, or salts thereof. [Claim 6] The preservative composition according to claim 1, wherein the preservative comprises a quaternary ammonium compound such as an alkyl(C12-22)trimethylammonium compound, a benzethonium compound, or a mixture thereof. [Claim 7] The preservative composition according to claim 1, wherein the preservative comprises an alcohol such as a lower alkyl alcohol or an aromatic alcohol. [Claim 8] The preservative composition according to claim 7, wherein the aromatic alcohol comprises phenoxyethanol and the lower alkyl alcohol comprises isopropanol. [Claim 9] The preservative composition according to any one of claims 1 to 8, wherein the polyglycerol ester comprises (a) a polyglycerol component consisting of 2 to 12 glycerol molecules based on an average value, and (b) a polyglycerol ester derived from fatty acids including caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, cerotic acid, oleic acid, or decaoleic acid. [Claim 10] The preservative composition according to claim 9, wherein the polyglyceryl fatty acid ester comprises one or more polyglyceryl-10 laurate, polyglyceryl-10 decaoleate; polyglyceryl-3 monostearate; polyglyceryl-6 distearate, polyglyceryl-10 stearate; polyglyceryl-10 oleate; polyglyceryl-10 dipalmitate; or polyglyceryl-10 caprylic / caprate. [Claim 11] A method for increasing the efficacy of preservatives in the final product, wherein the final product and A method comprising the steps of providing a preservative and adding an effective amount of polyglycerol ester to the preservative and the final formulation in order to increase the efficacy of the preservative in the final formulation compared to an equivalent amount of preservative without the polyglycerol ester. [Claim 12] The method according to claim 11, wherein the polyglycerol ester is added to the preservative before the preservative is added to the final product, or the preservative is added to the final product before the polyglycerol ester is added to the final product, or the polyglycerol ester is added to the final product before the preservative is added to the final product, or the preservative and the polyglycerol ester are added to the final product simultaneously. [Claim 13] A final-use formulation containing the preservative described in any one of claims 1 to 10, such as a personal care formulation or a home care formulation.

Claims

1. (i) Preservatives comprising acid compounds, phenolic compounds, sulfites, iron chelating agents, aromatic alcohols, quaternary ammonium compounds, pyrone compounds, urea compounds, imidazole compounds, isothiazolinone compounds, or combinations of two or more preservatives; and (ii) A polyglycerol ester present in an amount that sufficiently increases the efficacy of the preservative compared to the preservative alone, and the amount of increase is greater than the additive effect of the biocidic activity of the preservative and the polyglycerol ester used alone. Includes, A preservative composition in which the weight ratio of the polyglycerol ester to the preservative is in the range of 0.0001 to 2.

0.

2. The preservative composition according to claim 1, wherein the weight ratio of the polyglycerol ester to the preservative is in the range of 0.001 to 1.5, for example, in the range of 0.01 to 1.

0.

3. The preservative composition according to claim 1, wherein the preservative comprises an iron chelating agent, and the iron chelating agent comprises a pyrithione compound such as zinc pyrithione, sodium pyrithione or a mixture thereof, piroctone olamine, 2-pyridinol-1-oxide, N-hydroxy-6-octyloxypyridine 2(1H)-one, -hydroxy-6-octyloxypyridine 2(1H)-one ethanolamine salt or a mixture thereof.

4. The preservative composition according to claim 1, wherein the preservative is an acid compound such as an acid, an ester of an acid, or a salt of an acid.

5. The preservative composition according to claim 4, wherein the acid compound comprises benzoic acid, propionic acid, salicylic acid, sorbic acid, formic acid, undeca-10-enoic acid, lactic acid, glycolic acid, and citric acid, or salts thereof.

6. The preservative composition according to claim 1, wherein the preservative comprises a quaternary ammonium compound such as an alkyl (C12-22) trimethylammonium compound, a benzethonium compound, or a mixture thereof.

7. The preservative composition according to claim 1, wherein the preservative comprises an alcohol such as a lower alkyl alcohol or an aromatic alcohol.

8. The preservative composition according to claim 7, wherein the aromatic alcohol comprises phenoxyethanol and the lower alkyl alcohol comprises isopropanol.

9. The preservative composition according to any one of claims 1 to 8, wherein the polyglycerol ester comprises (a) a polyglycerol component consisting of 2 to 12 glycerol molecules based on an average value, and (b) a polyglycerol ester derived from fatty acids including caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, lignoceric acid, cerotic acid, oleic acid, or decaoleic acid.

10. The preservative composition according to claim 9, wherein the polyglyceryl fatty acid ester comprises one or more polyglyceryl-10 laurate, polyglyceryl-10 decaoleate; polyglyceryl-3 monostearate; polyglyceryl-6 distearate, polyglyceryl-10 stearate; polyglyceryl-10 oleate; polyglyceryl-10 dipalmitate; or polyglyceryl-10 caprylic / caprate.

11. A method for increasing the efficacy of a preservative in a final-use formulation, comprising the steps of: providing a final-use formulation and a preservative; and adding an effective amount of polyglycerol ester to the preservative and the final-use formulation in order to increase the efficacy of the preservative in the final-use formulation compared to an equivalent amount of preservative without the polyglycerol ester.

12. The method according to claim 11, wherein the polyglycerol ester is added to the preservative before the preservative is added to the final product, or the preservative is added to the final product before the polyglycerol ester is added to the final product, or the polyglycerol ester is added to the final product before the preservative is added to the final product, or the preservative and the polyglycerol ester are added to the final product simultaneously.

13. A final-use formulation containing the preservative described in any one of claims 1 to 10, such as a personal care formulation or a home care formulation.

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