Tablet-type skin cleansing

Abstract

To provide a novel, non-foaming, tablet-type skin cleanser. [Solution] A tablet-type skin cleansing agent characterized by containing (A) to (C). (A) Bar-shaped crystalline cellulose (B) Anionic surfactants (C) One or more of the following: acrylates crosspolymer-2-Na, carboxymethyl starch sodium.

Description

[Technical Field]

[0001] This invention relates to a tablet-shaped (tablet-like) skin cleansing agent. [Background technology]

[0002] Tablet-shaped skin cleansing agents (hereinafter also referred to as tablet-shaped cleansing agents) are known, which are formed by compressing powder. Tablet-shaped cleansing agents are required to disintegrate quickly upon contact with water and to have excellent usability, such as rapid foaming and foam volume. To improve the disintegration properties of tablet-shaped cleansing agents, for example, Patent Documents 1 and 2 propose the incorporation of carbonates and acids, which are foaming components; Patent Document 3 proposes increasing the voids to a macroporosity of 15% or more; and Patent Document 4 proposes the incorporation of croscarmellose sodium, which is a disintegrant.

[0003] Recently, non-foaming skin cleansers have been attracting attention as a type of skin cleanser. However, the inventors' research has revealed that, at present, no non-foaming skin cleanser in tablet form is on the market. [Prior art documents] [Patent Documents]

[0004] [Patent Document 1] Japanese Patent Application Publication No. 62-030197 [Patent Document 2] Japanese Patent Application Publication No. 5-247495 [Patent Document 3] Japanese Patent Application Publication No. 10-183198 [Patent Document 4] Japanese Patent Publication No. 2007-126574 [Overview of the Initiative] [Problems that the invention aims to solve]

[0005] The present invention aims to provide a novel, non-foaming, tablet-type skin cleansing agent. [Means for solving the problem]

[0006] The means for solving the problems of the present invention are as follows. 1. A tablet-type skin cleansing agent characterized by containing (A) to (C). (A) Bar-shaped crystalline cellulose (B) Anionic surfactants (C) One or more of the following: acrylates crosspolymer-2-Na, carboxymethyl starch sodium. 2. (D) The tablet-type skin cleansing agent according to 1, characterized by containing other crystalline cellulose. 3. The tablet-type skin cleansing agent according to 1. or 2., characterized in that the proportion of total crystalline cellulose (A+D) to the whole is 45% by mass or more. 4. A tablet-type skin cleansing agent according to any one of 1 to 3, characterized in that the ratio of (A) rod-shaped crystalline cellulose (A / (A+D)) to total crystalline cellulose (A+D) is 15% by mass or more. 5. A tablet-type skin cleansing agent according to any one of 1 to 4, characterized in that the proportion of (C) to the whole is 0.5% by mass or more and 15% by mass or less. [Effects of the Invention]

[0007] The present invention provides a novel, non-foaming, tablet-type skin cleanser. The tablet-type skin cleanser of the present invention has excellent moldability and disintegration properties, and can be formed into a smooth paste with excellent thickness and spreadability. The skin cleansing agent of the present invention is in tablet form and does not contain water, so it can be preservative-free. Because the skin cleansing agent of the present invention is in tablet form, it is easy to carry and store. The skin cleansing agent of the present invention uses less water in the manufacturing process, making it promising from the standpoint of water resource conservation. [Modes for carrying out the invention]

[0008] The tablet-type skin cleanser of the present invention contains (A) rod-shaped crystalline cellulose, (B) anionic surfactant, and (C) one or more of acrylates crosspolymer-2-Na and carboxymethyl starch sodium. By containing these components (A), (B), and (C), the tablet-type skin cleanser of the present invention has excellent moldability and disintegration properties, and when water is added, a high-quality paste with an excellent feel when applied can be obtained.

[0009] (A) Bar-shaped crystalline cellulose The tablet-type skin cleanser of the present invention contains (A) rod-shaped crystalline cellulose. In this specification, rod-shaped crystalline cellulose means crystalline cellulose with an aspect ratio (long axis / short axis) of 3 or more. By containing rod-shaped crystalline cellulose with an aspect ratio (long axis / short axis) of 3 or more, the tablet-type skin cleanser of the present invention can be made into a smooth paste with excellent thickness and spreadability. In the present invention, the aspect ratio of the rod-shaped crystalline cellulose is preferably 3.2 or more, more preferably 3.5 or more, even more preferably 4.0 or more, and even more preferably 4.2 or more.

[0010] The rod-shaped crystalline cellulose preferably has a particle size of 30 μm or more and 80 μm or less. If the particle size is less than 30 μm, the thickness of the paste may decrease, and if it exceeds 80 μm, the paste may become rough. The particle size of the rod-shaped crystalline cellulose is more preferably 35 μm or more, even more preferably 40 μm or more, even more preferably 70 μm or less, and even more preferably 60 μm or less. Generally, the aspect ratio is determined from electron microscopy observation of powders, and the particle size is measured by sieving tests, electron microscopy observation, or particle size distribution measurement using laser diffraction / scattering methods. In this invention, the aspect ratio (major axis / minor axis) of crystalline cellulose is calculated by observing 1000 or more crystalline cellulose particles using an electron microscope, and for 100 to 200 particles in order of decreasing particle area, the major axis is the length of the axis with the longest length from end to end of the particle (major axis), and the minor axis is the length of the particle perpendicular to the major axis at the center of the major axis. The average value of these values ​​is calculated. The particle size is calculated as a cumulative 50% by weight using a sieving test (JIS Z 8815).

[0011] The rod-shaped crystalline cellulose preferably has an angle of repose of 46 degrees or more. Incorporating rod-shaped crystalline cellulose with an angle of repose of 46 degrees or more tends to improve the thickness of the paste. The angle of repose of the rod-shaped crystalline cellulose is more preferably 47 degrees or more, even more preferably 48 degrees or more, and even more preferably 49 degrees or more. The rod-shaped crystalline cellulose preferably has a water absorption capacity of 200% (w / w) or higher. Because rod-shaped crystalline cellulose with a water absorption capacity of 200% or higher readily mixes with water, it is easy to obtain a smooth paste. The water absorption capacity of the rod-shaped crystalline cellulose is more preferably 210% (w / w) or higher, and even more preferably 220% (w / w) or higher. In this invention, the water absorption capacity is a value calculated by a method conforming to the oil absorption test (JIS K 5101-13) of the pigment testing method.

[0012] As the rod-shaped crystalline cellulose, rod-shaped crystalline cellulose among the crystalline celluloses used as pharmaceutical additives or food additives can be used without particular limitation. For example, commercially available products such as "Ceolus ST-02", "Ceolus ST-100", "Ceolus OD-20F" sold by Asahi Kasei Corporation, "VIVAPUR CS 20 FM" sold by Rettenmaier Japan Co., Ltd., "Compressel 101" sold by Fushimi Pharmaceutical Co., Ltd. can also be used. Further, the rod-shaped crystalline cellulose can be used alone or in combination of two or more kinds having different aspect ratios, particle diameters, angles of repose, water absorption degrees, etc.

[0013] (D) Other crystalline cellulose The tablet-shaped skin cleanser of the present invention can contain (D) other crystalline cellulose having an aspect ratio of less than 3. However, when the tablet-shaped skin cleanser of the present invention contains (D) other crystalline cellulose, the ratio of (A) rod-shaped crystalline cellulose to the total crystalline cellulose (A+D) (A / (A+D)) is preferably 15% by mass or more. When the ratio of (A) rod-shaped crystalline cellulose to the total crystalline cellulose is less than 15% by mass, the good paste feeling due to the blending of (A) rod-shaped crystalline cellulose may decrease. The ratio of (A) rod-shaped crystalline cellulose to the total crystalline cellulose is more preferably 20% by mass or more, further preferably 30% by mass or more, still further preferably 40% by mass or more, still further preferably 50% by mass or more, still further preferably 60% by mass or more, still further preferably 70% by mass or more, still further preferably 80% by mass or more, still further preferably 90% by mass or more, still further preferably 95% by mass or more, still further preferably 98% by mass or more, and still further preferably 99% by mass or more.

[0014] In the tablet-shaped skin cleanser of the present invention, the proportion of the total crystalline cellulose (A + D, where (D) is optional) is not particularly limited, but it is preferably 45% by mass or more based on the whole. If the proportion of the total crystalline cellulose is less than 45% by mass, the formability may decrease. The proportion of the total crystalline cellulose based on the whole is more preferably 50% by mass or more, further preferably 60% by mass or more, and even more preferably 70% by mass or more. Also, the upper limit of the proportion of the total crystalline cellulose based on the whole is not particularly limited as long as the effects of the present invention are achieved, but for example, it can be 95% by mass or less, 90% by mass or less, 85% by mass or less, etc.

[0015] (B) Anionic surfactant Examples of the anionic surfactant include higher fatty acid salts, N-acylglycine salts, N-acylglutamic acid salts, N-acylalanine salts, N-acylisethionic acid salts, N-acylmethyltaurine salts, monoalkyl phosphate salts, ether carboxylate salts, alkyl sulfonate salts, sulfosuccinate salts, and the like. Examples of the acyl group in the above-mentioned N-acyl-based anionic surfactant include an octanoyl group, a decanoyl group, a lauroyl group, a myristoyl group, a palmitoyl group, a stearoyl group, an oleoyl group, a linoleoyl group, and the like. The acyl group may be derived from a mixed fatty acid, and specific examples include a coconut oil fatty acid acyl group (cocoyl group), a palm oil fatty acid acyl group, a palm kernel oil fatty acid acyl group, a beef tallow fatty acid acyl group, and the like. Examples of the salt include alkali metal salts such as sodium and potassium, alkanolamine salts such as triethanolamine, and basic amino acid salts such as lysine and arginine. The anionic surfactant can be used alone or in combination of two or more different kinds.

[0016] The content of component (B) in the tablet-type skin cleansing composition of the present invention is not particularly limited, but it is preferably 0.5% by mass or more and 20% by mass or less of the total. If the content of component (B) is less than 0.5% by mass, the cleansing power may be insufficient, and if it exceeds 20% by mass, it may be difficult to obtain a good paste. The proportion of component (B) to the total is more preferably 1% by mass or more, even more preferably 2% by mass or more, even more preferably 15% by mass or less, even more preferably 10% by mass or less, and even more preferably 5% by mass or less.

[0017] • Other surfactants The tablet-type skin cleansing composition of the present invention may contain other surfactants in addition to (B) anionic surfactants, such as amphoteric surfactants, cationic surfactants, and nonionic surfactants. If the tablet-type skin cleansing composition of the present invention contains other surfactants, it is preferable that it contains 50% by mass or more of (B) anionic surfactant relative to the total amount of surfactants. If the amount of (B) anionic surfactant is less than 50% by mass, the usability may decrease. The ratio of (B) anionic surfactant to the total amount of surfactants is more preferably 60% by mass or more, even more preferably 70% by mass or more, even more preferably 80% by mass or more, even more preferably 90% by mass or more, and even more preferably 95% by mass or more.

[0018] (C) Acrylates Crosspolymer-2-Na, Carboxymethyl Starch Sodium (C) Component is a water-soluble polymer. The tablet-type skin cleansing agent of the present invention, by containing either (C) acrylates crosspolymer-2-Na, carboxymethyl starch sodium, or both, exhibits excellent disintegration properties and can be formed into a high-quality paste. The content of component (C) in the tablet-type skin cleanser of the present invention is not particularly limited, but it is preferably 0.5% by mass or more and 15% by mass or less of the total. If the content of component (C) is less than 0.5% by mass, the quality of the paste may deteriorate, and if it exceeds 15% by mass, the rinseability may deteriorate. The proportion of component (C) to the total is more preferably 1% by mass or more, even more preferably 2% by mass or more, more preferably 10% by mass or less, even more preferably 7% by mass or less, and even more preferably 5% by mass or less.

[0019] Other ingredients The tablet-type skin cleansing composition of the present invention may contain polyhydric alcohols, sugars, sugar alcohols, preservatives, metal ion chelating agents, pharmaceutically active ingredients, fillers (excipients), disintegrants, lubricants, fragrances, etc., to the extent that they do not impair the effects of the present invention.

[0020] Examples of polyhydric alcohols, sugars, and sugar alcohols include glycerin, diglycerin, 1,3-butylene glycol (BG), propylene glycol, dipropylene glycol, 1,2-pentanediol, sorbitol, mannose, mannitol, galactose, galactitol, maltose, trehalose, erythrulose, erythritol, xylose, xylitol, sucrose, lactose, lactitol, and difructose anhydride.

[0021] Examples of preservatives include methylparaben and ethylparaben. However, since the tablet-type skin cleansing agent of the present invention does not contain water and is not conducive to bacterial growth, the amount of preservative added is preferably 0.5% by mass or less of the total amount, more preferably 0.1% by mass or less, and most preferably no preservative at all. Examples of metal ion chelating agents include disodium ethylenediaminetetraacetate, edetate, and edetate salts such as sodium edetate salt. Examples of medicinal ingredients include vitamin C derivatives such as L-ascorbic acid, L-ascorbic acid phosphate, L-ascorbic acid monopalmitate, L-ascorbic acid dipalmitate, and L-ascorbic acid-2-glucoside; whitening agents such as glutathione and Saxifraga stolonifera extract; skin activators such as royal jelly and beech tree extract; blood circulation promoters such as capsaicin, gingerol, cantharis tincture, caffeine, tannic acid, and γ-oryzanol; anti-inflammatory agents such as glycyrrhizic acid derivatives and azulene; and enzymes such as protease and lysozyme chloride.

[0022] Examples of fillers (excipients) include lactose, magnesium aluminometasilicate, calcium silicate, talc, kaolin, silica, mica, zeolite, bentonite, titanium dioxide, and dextrin. Examples of disintegrants include croscarmellose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinyl alcohol, polyacrylic acid, sodium polyacrylate, polymethacrylic acid, gum arabic, gelatin, agar, pullulan, and cross-linked polyvinylpyrrolidone. Examples of lubricants include calcium stearate, magnesium stearate, and sucrose esters.

[0023] The tablet-type skin cleansing agent of the present invention can be compressed into tablets by known methods. [Examples]

[0024] Each component was mixed in the mass ratios shown in Tables 1-4, and tablets (approximately 800 mg) were prepared by compressing them under a pressure of 300 kg. The components used are as follows: (A) Bar-shaped crystalline cellulose Rod-shaped crystalline cellulose 1 [4.36, 50 μm, 49°C, 230%, 0.21 g / cm³] 3 (Manufactured by Asahi Kasei Corporation, Ceolus ST-02) Rod-shaped crystalline cellulose 2 [4.70, 50 μm, 57°C, 290%, 0.12 g / cm³] 3(Manufactured by Asahi Kasei Corporation, Ceolus ST-100) (D) Other crystalline cellulose Crystalline cellulose 1 [2.45, 90μm, 42 degrees, 240%, 0.29 g / cm 3 (Manufactured by Asahi Kasei Corporation, Ceolus UF-F702) Crystalline cellulose 2 [2.57, 50μm, 34 degrees, 240%, 0.23 g / cm 3 (Manufactured by Asahi Kasei Corporation, Ceolus UF-F711) Crystalline cellulose 3 [2.37, 50μm, 45 degrees, 200%, 0.29 g / cm 3 (Manufactured by Asahi Kasei Corporation, Ceolus PH-101) Crystalline cellulose 4 [2.05, 90μm, 42 degrees, 200%, 0.31 g / cm 3 (Manufactured by Asahi Kasei Corporation, Ceolus PH-102) Crystalline cellulose 5 [1.97, 170μm, 36 degrees, 200%, 0.34 g / cm 3 (Manufactured by Asahi Kasei Corporation, Ceolus PH-200) Crystalline cellulose 6 [2.20, 50μm, 41 degrees, 150%, 0.41 g / cm 3 (Manufactured by Asahi Kasei Corporation, Ceolus FD-301) The numerical values in [ ] represent aspect ratio, average particle size (μm), angle of repose (degrees), water absorption (%(w / w)), and bulk density (g / cm 3 ).

[0025] (B) Anionic surfactant Sodium lauroyl glutamate (manufactured by Asahi Kasei Fine Chemicals Corporation, Aminosurfact ALMS-P1) Sodium lauroyl aspartate (manufactured by Asahi Kasei Fine Chemicals Corporation, Aminofoamer FLMS-P1) Potassium cocoyl glycinate (manufactured by Ajinomoto Co., Inc., Amilite GCK-11) Sodium cocoyl isethionate (Innospec Performance Chemicals, Pureact I-78) Potassium myristate (manufactured by Miyoshi Oil & Fat Co., Ltd., Cosmetic Soap MF-K)

[0026] (C) Acrylates crosspolymer-2-Na (manufactured by Toagosei Co., Ltd., ARON NT-Z) Sodium carboxymethyl starch (Rettenmeyer Japan Co., Ltd., VIVASTAR CS352SV) Other water-soluble polymers Sodium carbomer (sodium polyacrylate) (manufactured by Sumitomo Seika Co., Ltd., AQUPEC MG N40R) Sodium polyacrylate (Sensient Technologies Japan, COVACRYL MV 60) Polyvinyl alcohol (manufactured by Mitsubishi Chemical Corporation, Gosenol EG-05) PVP (Ashland Specialty Ingredients, PVP K-30)

[0027] Magnesium stearate (manufactured by NOF Corporation, Magnesium Stearate-S) Silica (Saint-Gobain Boron Nitride, AEROSIL R812) Mannitol (Mitsubishi Corporation Life Sciences Co., Ltd., Marine Crystal)

[0028] "Evaluation Method" The resulting tablet-type skin cleansing agents were evaluated as follows. The results of each evaluation are shown in Tables 1-4. ·Moldability The moldability of the tablet-shaped skin cosmetic was evaluated by visually observing its appearance, according to the following criteria. <Evaluation Criteria> ○: The tablet surface is glossy, free of chips, and maintains its tablet shape even after observation. ×: The tablet surface is powdery, chipped, or unable to maintain its tablet shape after observation.

[0029] • Collapse After splitting the tablet-type skin cleanser in half, 2.5 mL of water was added, and it was allowed to stand for 5 seconds. Then, it was rubbed in the palm of the hand, and its disintegration properties were evaluated according to the following criteria. If the disintegration evaluation was "×", no further evaluation was performed. <Evaluation Criteria> ○: It will disintegrate within 5 seconds of standing still. △: Breaks down during the blending process. ×: Clumps remain even after blending.

[0030] ·Usability After splitting the tablet-type skin cleanser in half, 2.5 mL of water was added, and it was allowed to stand for 5 seconds. Then, it was rubbed into the palm of the hand, and its usability was evaluated according to the following criteria. <Evaluation Criteria> 1) Ease of spreading (Does it spread well and produce a smooth paste?) ○: Smooth and spreads evenly. △: Slightly less smooth, but spreads evenly. ×: It lacks smoothness and cannot be spread evenly. 2) Massageability during application (Does the paste have a good thickness and is it easy to massage with?) ○: It has a good thickness, making it easy to massage with. △: Slightly thick, but acceptable. ×: It lacks thickness and is difficult to massage with. 3) Irritation during application (Does it feel smooth and not cause any physical irritation to the skin during application?) ○: I don't feel any stimulation. △: Slightly irritating, but tolerable. ×: To feel a sensation. 4) Ease of rinsing (How quickly can it be rinsed off with water after use?) ○: Rinses off quickly. △: Rinsing is a little slow, but acceptable. ×: It takes a long time to rinse off. 5) Moisturizing effect after rinsing (Does your skin feel moisturized and not tight after rinsing?) ○: I feel a moisturizing effect. △: I don't feel much moisturizing effect, but it's acceptable. ×: Does not feel moisturizing.

[0031] [Table 1]

[0032] [Table 2]

[0033] [Table 3]

[0034] [Table 4]

[0035] "result" The tablet-type skin cleansing agent obtained in the example containing rod-shaped crystalline cellulose exhibited excellent usability, and in particular, it was possible to obtain a paste with a substantial thickness. The tablet-type skin cleansing agents obtained in Comparative Examples 1-6, which contained only non-rod-shaped crystalline cellulose, had poor usability, and in particular, lacked sufficient paste thickness. Furthermore, the tablet-type skin cleansing agents obtained in Comparative Examples 7-10, which did not contain component (C), had poor disintegration properties.

[0036] The following are examples of formulations for tablet-type skin cleansing agents. According to formulations 1-3, it was possible to obtain a tablet-type skin cleansing agent that has excellent moldability, disintegration properties, and a smooth paste-like consistency with excellent thickness and spreadability, as well as excellent usability.

[0037] [Prescription Example 1] Tablet Pack Ingredients Amount (mass%) Rod-shaped crystalline cellulose 77.05 Sodium lauroyl glutamate 2.00 Sodium stearoyl glutamate 0.80 Sodium Cocoyl Glutamate 0.20 Cocoyl Glycinate K 2.00 Mannitol 13.00 Acrylates crosspolymer-2-Na 4.00 Protease 0.10 Lipase 0.10 Magnesium stearate 0.25 Silica 0.50

[0038] [Prescription Example 2] Tablet Pack Ingredients Amount (mass%) Rod-shaped crystalline cellulose 79.65 Sodium lauroyl glutamate 3.00 Sodium Cocoyl Isethionate 1.00 Pullulan 0.50 Mannitol 5.00 Glucose 7.00 Carboxymethyl starch sodium 3.00 Charcoal 0.10 Magnesium stearate 0.25 Silica 0.50

[0039] [Prescription Example 3] Tablet Pack Ingredients Amount (mass%) Rod-shaped crystalline cellulose 72.35 Sodium lauroyl glutamate 1.90 Sodium lauroyl aspartate 1.50 Sodium stearoyl glutamate 1.60 Sodium Cocoyl Glutamate 0.40 Acrylates crosspolymer-2-Na 3.00 Agar 0.50 Mannitol 14.00 Maltitol 4.00 Magnesium stearate 0.25 Silica 0.50

Claims

1. A tablet-type skin cleansing agent characterized by containing (A) to (C). (A) Rod-shaped crystalline cellulose (B) Anionic surfactants (C) One or more of the following: acrylates crosspolymer-2-Na, carboxymethyl starch sodium.

2. (D) The tablet-type skin cleanser according to claim 1, characterized by containing other crystalline cellulose.

3. The tablet-type skin cleansing composition according to claim 1 or 2, characterized in that the proportion of total crystalline cellulose (A + D) to the whole is 45% by mass or more.

4. The tablet-type skin cleansing agent according to claim 1 or 2, characterized in that the ratio of (A) rod-shaped crystalline cellulose to total crystalline cellulose (A + D) (A / (A + D)) is 15% by mass or more.

5. The tablet-type skin cleansing composition according to claim 1 or 2, characterized in that the proportion of (C) to the whole is 0.5% by mass or more and 15% by mass or less.

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