tablet

Abstract

The purpose of this disclosure is to provide a tablet containing black ginger extract with improved tablet hardness. [Solution] The tablets of this disclosure contain (A) black ginger extract and (B) green tea extract.

Description

Technical Field

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[0001] The present disclosure relates to tablets containing black ginger extract and having improved tablet hardness.

Background Art

[0002] It is known that black ginger contains active ingredients having various useful physiological effects such as antioxidant action, anti-aging action, and anti-inflammatory action (Patent Document 1), and it is used by being formulated in health foods.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] Among foods, tablets are a highly convenient and consumer-preferred dosage form because they can be ingested by drinking with water or the like without feeling the taste of functional ingredients. However, black ginger extract has a specific property of poor compression molding property. When tableted into tablets, sufficient hardness cannot be obtained, and the surface is easily worn, or cracks are likely to occur during filling into containers and distribution (transportation).

[0005] Therefore, an object of the present disclosure is to provide a tablet containing black ginger extract and having improved tablet hardness.

Means for Solving the Problems

[0006] The inventors of the present invention conducted diligent research to solve the aforementioned problems and discovered that by combining black ginger extract with green tea extract and then compressing the tablets, tablets with improved hardness can be obtained. This disclosure was completed by further research based on this finding.

[0007] In other words, this disclosure provides inventions in the following embodiments. Item 1: Tablets containing (A) black ginger extract and (B) green tea extract. Item 2 The tablet according to Item 1, wherein, on a dry weight basis, it contains 0.1 to 10 parts by weight of component (B) per 1 part by weight of component (A). Item 3 A tablet according to item 1 or 2, wherein the content of component (A) is 1 to 80% by weight on a dry weight basis. Item 4 A tablet according to any one of items 1 to 3, wherein the content of component (B) is 0.1 to 80% by weight on a dry weight basis. Item 5 (A) A method for improving the hardness of tablets containing black ginger extract, A method for improving the hardness of a tablet, comprising (A) a tablet containing black ginger extract and (B) a tablet containing green tea extract. [Effects of the Invention]

[0008] Even though the tablets of this disclosure contain black ginger extract, their hardness has been improved, making them less prone to breakage during filling into containers and during distribution (transportation). [Modes for carrying out the invention]

[0009] 1. Tablets The tablets of this disclosure contain (A) black ginger extract (hereinafter also referred to as "(A) component") and (B) green tea extract (hereinafter also referred to as "(B) component"). The tablets of this disclosure are described in detail below. In this specification, numerical ranges indicated by two numbers and "~" include those two numbers as the lower and upper limits. For example, the notation 2-15% by weight means 2% by weight or more and 15% by weight or less.

[0010] (A) Black ginger extract The tablets of this disclosure contain black ginger extract as component (A). When black ginger extract is compressed into tablets, it does not have sufficient hardness and is prone to cracking during filling into containers and during distribution (transportation). However, the tablets of this disclosure are formulated by combining black ginger extract with green tea extract during tablet molding, resulting in improved tablet hardness and making them less prone to cracking during filling into containers and during distribution (transportation).

[0011] Black ginger extract is an ingredient obtained by extracting black ginger as the raw material. Black ginger, also known as black ginger, is a plant (Kaempferia parviflora) belonging to the genus Kaempferia in the family Zingiberaceae.

[0012] The extraction process can be any common extraction method used in the production of plant extracts, such as solvent extraction, supercritical fluid extraction, and steam distillation. Among these, solvent extraction is preferred.

[0013] Examples of extraction solvents used in solvent extraction include water; lower monohydric alcohols having 1 to 4 carbon atoms such as methanol, ethanol, n-propanol, isopropanol, and n-butanol; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; hydrophilic solvents such as acetone; and mixed solvents thereof. Among these extraction solvents, water, lower monohydric alcohols, and mixed solvents thereof are preferred, more preferably water, ethanol, and mixed solvents thereof, and even more preferably a mixed solvent of water and ethanol. When a mixed solvent of water and a lower monohydric alcohol is used as the extraction solvent, the content of the lower monohydric alcohol in the mixed solvent is, for example, 10 to 90% by volume, preferably 20 to 80% by volume, more preferably 20 to 60% by volume, and even more preferably 25 to 55% by volume.

[0014] The solvent extraction process involves immersing the target part of black ginger (preferably the rhizome), which has been dried, cut, or crushed as necessary to improve extraction efficiency, in an extraction solvent and stirring as needed. For example, immersion in approximately 0.3 to 20 L of extraction solvent, preferably 0.5 to 1.5 L, per 100 g of the target part of black ginger for approximately 0.5 to 24 hours is sufficient. The temperature conditions for the solvent extraction process are not particularly limited, but are, for example, approximately 40 to 95°C.

[0015] After the extraction process, solid matter is removed by solid-liquid separation to obtain an extract of black ginger. The extract obtained from the extraction process may be purified as needed by filtration or adsorption treatment using various chromatography methods such as polystyrene gel (polystyrene-divinylbenzene copolymer, etc.), ion exchange resin, or activated carbon column packed with a support. The obtained extract is concentrated and used as black ginger extract. Specific forms of black ginger extract include soft extract and dried extract, with dried extract being preferred.

[0016] In the tablets of this disclosure, the content of component (A) can be appropriately set according to the amount ingested per serving, etc., but for example, on a dry weight basis, it is usually 1 to 90% by weight, and from the viewpoint of improving physiological effects such as antioxidant effect, anti-aging effect, and anti-inflammatory effect, and from the viewpoint of suppressing a decrease in the hardness of the tablets, it is preferably 1 to 80% by weight, more preferably 2 to 70% by weight, even more preferably 3 to 60% by weight, even more preferably 4 to 50% by weight, and particularly preferably 5 to 40% by weight. Because the tablets of this disclosure contain component (B), even if the content of component (A) is relatively high, they have sufficient hardness to withstand distribution and other processes.

[0017] (B) Green tea extract The tablets of this disclosure contain green tea extract as component (B). By combining green tea extract with black ginger extract and compressing the tablets, tablets with surprisingly improved hardness can be obtained.

[0018] The green tea extract is obtained by subjecting green tea (leaves of Camellia sinensis) to an extraction process using it as an extraction raw material.

[0019] As the extraction process for obtaining the green tea extract, general extraction methods described in the column of the "black ginger extract" can be mentioned, but preferably it is a solvent extraction process. The specific solvent extraction process is as described in the column of the "black ginger extract".

[0020] As the extraction solvent used in the solvent extraction process, preferably water, lower monohydric alcohols, and mixed solvents thereof, more preferably a mixed solvent of water and lower monohydric alcohols, particularly preferably a mixed solvent of water and ethanol. In the case of a mixed solvent of water and lower monohydric alcohols, the content of the lower monohydric alcohol is, for example, 10 to 90% by volume, preferably 20 to 80% by volume, more preferably 20 to 60% by volume, still more preferably 25 to 55% by volume.

[0021] By removing solids by solid-liquid separation after the extraction process, an extract of green tea is obtained. The extract obtained by the extraction process may be subjected to purification processes such as filtration and adsorption processes as necessary. The obtained extract is concentrated and used as a green tea extract. Specific forms of the green tea extract include soft extract and dry extract, and preferably dry extract.

[0022] In the tablets of the present disclosure, the content of component (B) may be appropriately set according to the degree required for the effect of improving tablet hardness. However, in terms of dry weight conversion, the content of component (B) per 1 part by weight of component (A) is usually 0.1 to 10 parts by weight. From the viewpoint of further increasing tablet hardness, it is preferably 0.2 to 8 parts by weight, more preferably 0.3 to 7 parts by weight, still more preferably 0.4 to 6 parts by weight, and even more preferably 0.5 to 5 parts by weight.

[0023] Furthermore, in the tablets of this disclosure, the content of component (B) may be set appropriately according to the desired degree of improvement in tablet hardness, but for example, on a dry weight basis, it is usually 0.1 to 90% by weight, preferably 0.1 to 80% by weight, more preferably 1 to 70% by weight, even more preferably 3 to 60% by weight, even more preferably 5 to 50% by weight, and particularly preferably 10 to 40% by weight.

[0024] Other ingredients In addition to the components described above, the tablets of this disclosure may contain other additives necessary for formulation into tablets, etc., to the extent that they do not interfere with the effects of this disclosure. Examples of such additives include excipients, binders, fluidizers, lubricants, disintegrants, acidulants, sweeteners, flavorings, and colorants. Specific examples of such additives include lactose, maltose, crystalline cellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose, silicon dioxide, sucrose fatty acid esters, calcium stearate, and magnesium stearate. These additives may be used individually or in combination of two or more. The content of these additives may be appropriately determined depending on the type of additive used.

[0025] Furthermore, the tablets of this disclosure may contain nutritional components and pharmacological components in addition to the components described above. The nutritional components and pharmacological components are not particularly limited as long as they are usable in food and pharmaceuticals, but examples include antacids, stomachic agents, digestive agents, intestinal regulators, antispasmodics, mucosal repair agents, anti-inflammatory agents, astringents, antiemetics, antitussives, expectorants, anti-inflammatory enzymes, sedatives, antihistamines, caffeine, cardiotonic and diuretic agents, antibacterial agents, vasoconstrictors, vasodilators, local anesthetics, herbal medicines, herbal medicine extracts, amino acids, vitamins, menthol, etc. These nutritional components and pharmacological components may be used individually or in combination of two or more. The content of these components may be appropriately determined depending on the type of component used.

[0026] Physical properties of tablets The tablets of this disclosure have a hardness that makes them resistant to breakage during filling into containers and during distribution (transportation). Specifically, the hardness of the tablets of this disclosure is 100N or higher, preferably 105N or higher, and more preferably 110N or higher. There is no particular upper limit to the hardness of the tablets of this disclosure, but it is usually 300N or lower, and from the viewpoint of disintegration during administration, it is preferably 250N or lower, more preferably 200N or lower, and even more preferably 150N or lower. In this disclosure, the hardness of the tablets is a value measured by a load cell type tablet hardness tester (test speed of break terminal 0.5 mm / sec).

[0027] Tablet shape and product classification The tablets of this disclosure may be used in their uncoated state, but may also be used as coated tablets by applying a coating such as sugar coating or film coating as needed.

[0028] The weight per tablet of the tablets disclosed herein can be set appropriately depending on the single dose, the amount of component (A) contained, etc., but for example, it can be around 200 to 400 mg.

[0029] The product classification of tablets in this disclosure is not particularly limited and may be any of the following: food and beverages (including foods for special dietary uses and health functional foods (nutrient function foods, foods with functional claims, foods for specified health uses, etc.), and general foods (nutritional supplements, health supplements, fortified foods, nutritional adjustment foods, supplements, etc.)) and oral pharmaceuticals (including quasi-drugs for oral use).

[0030] Manufacturing method The tablets of this disclosure are manufactured by compressing a raw material mixture containing components (A) and (B), and other components added as needed. The method of compressing is not particularly limited, but can be carried out using equipment such as a single-shot tablet press, a rotary tablet press, or a high-speed rotary tablet press. The compression pressure during tableting is not particularly limited as long as tablet formation is possible, but can usually be set to about 0.5 to 2.0 t, preferably about 0.8 to 1.8 t, and more preferably about 1.0 to 1.5 t. In addition, at least a portion of the raw material mixture to be used for tableting may be granulated in advance as needed.

[0031] 2. Method for improving the hardness of tablets This disclosure provides a method for improving the hardness of tablets containing black ginger extract. Specifically, the method for improving hardness is characterized by adding (B) green tea extract to (A) tablets containing black ginger extract. The types and amounts of ingredients used in this method for improving hardness, the method of forming the tablets, etc., are as described in section "1. Tablets" above. [Examples]

[0032] The present disclosure will be described in more detail below with reference to examples, but the present disclosure is not limited to these examples.

[0033] The details of the ingredients used in the following test examples and formulation examples are as follows: (A) component • Black ginger extract: A dried powder of extract obtained by extracting black ginger rhizome with an ethanol aqueous solution, containing 8% by weight of polymethoxyflavones. (B) Component Green tea extract: This is a powdered extract obtained by solvent extraction of tea leaves with an ethanol aqueous solution (containing 80% by weight of catechins and 60% by weight of gallate-type catechins).

[0034] Test example 1. Manufacturing of tablet samples Tablet samples with the composition shown in Table 1 were prepared. Specifically, predetermined amounts of the components shown in Table 1 were mixed, and the resulting mixed powder was compressed into tablets using a hydraulic tablet press (TB-20N, NPA System Co., Ltd.) at a pressure of 100N to obtain tablet samples of 306 mg each (8 mm in diameter, disc-shaped).

[0035] 2. Measurement of hardness The hardness of tablets was measured using a load cell type tablet hardness tester PC-30 (Okada Seikou Co., Ltd.) with the test speed of the fracture terminal set to 0.5 mm / second. The tablet hardness was taken as the average value of three tablet samples. The results are shown in Table 1. If the tablet hardness is 100 N or higher, it can be said that the tablet is less likely to break during filling into containers and during distribution (transportation).

[0036] [Table 1]

[0037] As shown in Table 1, the tablets of Comparative Example 1 or 2, which contained either black ginger extract or green tea extract, had insufficient tablet hardness. However, the tablets of Examples 1 to 3, which combined black ginger extract and green tea extract, showed higher tablet hardness compared to the tablets of Comparative Example 1 or 2, which contained either black ginger extract or green tea extract, yielding an unexpected result.

[0038] Prescription examples Tablets (306 mg) with the composition shown in Table 2 were manufactured. When the tablet hardness was measured using the same method as in the test examples, all tablets showed higher hardness compared to tablets containing black ginger extract or green tea extract (with the same other ingredients and their contents as in each formulation example).

[0039] [Table 2]

Claims

1. Tablets containing (A) black ginger extract and (B) green tea extract.

2. The tablet according to claim 1, wherein, on a dry weight basis, it contains 0.1 to 10 parts by weight of component (B) per 1 part by weight of component (A).

3. The tablet according to claim 1, wherein the content of component (A) is 1 to 80% by weight on a dry weight basis.

4. The tablet according to claim 1, wherein the content of component (B) is 0.1 to 80% by weight on a dry weight basis.

5. (A) A method for improving the hardness of tablets containing black ginger extract, A method for improving the hardness of a tablet, comprising (A) a tablet containing black ginger extract and (B) a tablet containing green tea extract.

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