Quinolinone amide compounds and their uses

Abstract

Providing quinolinone amide compounds and their uses. [Solution] This disclosure generally relates to substituted quinolinoneamide compounds or salts of formula (I), (II-A), (IV), or (III), and pharmaceutically equivalent compositions thereof. The substituted quinolinoneamide compounds or salts may be used to treat or prevent heart disease in individuals where such treatment is necessary. TIFF2026090424000406.tif65134

Description

[Technical Field]

[0001] cross reference This application is U.S. Provisional Patent Application No. 63 / 492,441, filed on March 27, 2023. Claiming the interests of, this U.S. provisional patent application is incorporated herein by reference in its entirety. . [Background technology]

[0002] Background of the Invention More than 80 million people have one or more forms of heart disease, and residents It is a leading cause of death, claiming nearly 18 million lives each year. The onset of heart disease is a significant risk factor for death. It can be caused by either genetic characteristics or lifestyle. Myocardium is involuntary striated muscle of the heart. It has electrical stimulation in the form of an action potential. The action potential of the heart is the release of calcium from the sarcoplasmic reticulum. It induces a reaction. Cardiomyopathy is one example of a disease of the myocardium, but it is not limited to this. Heart failure, irregular heartbeat, short breaths, fatigue, and weakness are among the possible causes, but are not limited to these. It can cause severe symptoms, and those affected are at increased risk of sudden cardiac death.

[0003] Many medical treatments for heart disease do not address the underlying cause of the disease. Treatment is limited to managing symptoms. Furthermore, some treatments become more difficult as the duration of the disease increases. The efficacy decreases. Therefore, it is necessary to develop novel compounds for improved treatment of heart disease. It is still necessary.

[0004] Hypertrophic cardiomyopathy (HCM) is a chronic, progressive disease of the cardiac sarcomere. The etiology of HCM is multifaceted. It is factor-dependent; a significant proportion of those affected encode cardiac sarcomeric proteins. The gene has at least one mutation. Regardless of the cause of HCM, in many cases... Furthermore, excessive myosin-actin cross-bridge formation during systole and diastole is detrimental to movement. This leads to hyperkinetic contraction and relaxation disorders. Over time, this excessive stress causes muscle cell hypertrophy. Histologically characterized by large size, myofilamentous disorder, microvascular remodeling, and fibrosis. This leads to tissue remodeling. HCM can be hereditary (e.g., genetic) or non-hereditary. It can be hereditary. HCM includes hyperosmotic, monogenic, autosomal dominant cardiomyopathy. Such HCMs are proteins that contribute to sarcomeres, which are the functional units of cardiac muscle. One or more of the more than 1,000 known point mutations in any one of these Therefore, it can be caused by other known causes (for example) If left ventricular hypertrophy is found to be present that cannot be explained by hypertension or valvular heart disease, For example, once other hereditary (e.g., lysosomal storage disorders), metabolic or invasive Once the cause is ruled out, it may be shown that many of these have HCM.

[0005] Drug therapies for HCM are limited, and many patients' symptoms are treated with beta-blockers and non-dihydropyridinamides. It is empirically managed with calcium channel blockers and / or disopyramide. None of these active ingredients are labeled as HCM treatments, and essentially, their use Rigorous clinical trial evidence is not available to derive this conclusion. Approximately 60% of patients with HCM When the left ventricular outflow tract is obstructed, blood flow is impaired, and a pressure gradient is created between the LV lumen and the aorta. It occurs. In patients with hemodynamically significant outflow tract obstruction (gradient > 50 mmHg), clinical Although morbidity and mortality rates are significant, surgical myocardium is used to alleviate hemodynamic obstruction. Resection or alcohol septal ablation may be used to improve HCM and associated cardiac disorders. Novel therapeutic agents and methods that address the long-standing need for improved treatment are described herein. It will be provided. [Overview of the Initiative] [Means for solving the problem]

[0006] Summary of the Invention In certain respects, this disclosure refers to the compounds or salts disclosed herein, and pharmaceuticals. This disclosure provides a pharmaceutical composition containing an acceptable additive for the treatment of a disease. The present invention provides compounds and salts thereof for use in the following contexts: Compounds of formulas (I), (II-A), (IV), and (III), and their pharmaceutical compositions The invention also provides methods for use in the treatment of diseases. In several aspects, heart disease The treatment method is one of the following: formula (I), (II-A), (IV), or (III) The process may include administering the compound or salt of the compound to an individual in need. References

[0007] All publications, patents, and patent applications referred to herein are not to be treated as if they were individual publications. It is indicated that any publication, patent, or patent application is specifically incorporated on an individual basis for reference. It is incorporated herein by reference to the same extent as it is incorporated herein by reference. [Modes for carrying out the invention]

[0008] Detailed description of the invention Preferred embodiments of the present invention are shown and described herein, but such embodiments It will be obvious to those skilled in the art that the forms are provided only by example. Many variations Any modifications, changes, and substitutions that are now conceivable by those skilled in the art without departing from the present invention are acceptable. Various modifications to the embodiments of the present invention described herein may be made to implement the present invention. It should be understood that it may be used in this regard. The following claims are within the scope of the present invention. Defining the boundaries, and the methods and structures within the scope of these claims, as well as their equivalence Equivalents are intended to be covered by the claims.

[0009] In certain circumstances, this disclosure relates to the treatment of cardiac disease in individuals who require treatment for cardiac disease. A method for treatment is provided, and this method is based on the formulas (I), (II-A), and (IV) for effective quantities. or (III) includes the step of administering a compound.

[0010] Diseases treated by the methods described herein include heart disease, however Cardiac diseases treated by the methods described herein include myocardial infarction. Diseases (cardiomyopathy), hypertrophic cardiomyopathy (HCM), abnormal heart rhythm MS, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic (RH) (ematic) Examples include heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism. This is not limited to these.

[0011] Cardiomyopathy is a condition in which the heart becomes abnormally enlarged, thickened, and / or hardened. It is a heart disease that has the following characteristics, and in its early stages may have few or no symptoms. As the disease worsens, symptoms include shortness of breath, fatigue, arrhythmia, fainting, and heart failure. This includes, but is not limited to, these conditions. Types of cardiomyopathy include arrhythmic right ventricular dysplasia, Dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and takotsubo cardiomyopathy are examples of these conditions. These are not the only options.

[0012] Hypertrophic cardiomyopathy (HCM) can be hereditary (e.g., genetic) or non-hereditary (e.g., non-hereditary). It can be obstructive. HCM can be obstructive or non-obstructive. Hereditary hypertrophic cardiomyopathy (HC M) includes a group of hyperosmotic, monogenic, autosomal dominant cardiomyopathy. HCM refers to cardiomyopathy. 1,00 in any one of the proteins that contribute to the sarcomere, which is the functional unit of the protein It can be caused by one or more known point mutations greater than zero.

[0013] In approximately two-thirds of HCM subjects, the left ventricular outflow tract (LVOT), also known as the heart's outflow tract, was affected. The pathway through which blood flows from the heart is blocked by enlarged and diseased muscles, preventing it from reaching other parts of the body. It restricts blood flow to the area (obstructive HCM). In other subjects, the thickened myocardium is LV Without blocking the OT, the disease is a diastolic dysfunction caused by hypertrophied and hardened myocardium (non-occlusive). Driven by sexual HCM. In both occlusive and non-occlusive HCM subjects. However, exertion can cause fatigue or shortness of breath, affecting the subject's ability to participate in daily activities. HCM also hinders the development of atrial fibrillation, stroke, heart failure, and sudden cardiac death. It is also related to this.

[0014] While the treatments currently available for HCM may be effective in various ways in alleviating symptoms, the disease itself... As the duration of action increases, the effectiveness may decrease. Therefore, patients should be advised to use beta-blockers. Experience with non-dihydropyridine calcium channel blockers and / or disopyramides. It can be managed appropriately. Mabacamten may also be used. Approximately 60% of patients with HCM have odor. When the left ventricular outflow tract is obstructed, blood flow is impaired, creating a pressure gradient between the left ventricular lumen and the aorta. In patients with hemodynamically significant outflow tract obstruction (gradient > 50 mmHg), clinical morbidity Although the rates and mortality are significant, surgical myocardial resection is used to alleviate hemodynamic obstruction. Surgery or alcohol septal ablation may be used to improve HCM and associated cardiac disorders. This specification provides novel therapeutic agents and methods that address long-standing needs regarding the treatment of these conditions. It will be done.

[0015] The compounds of the present invention or their pharmaceutically acceptable salts are used to treat HCM and other diseases. Rather than temporarily alleviating symptoms, these natural history can be altered. Clinically in HCM patients The mechanism that provides the benefit is similar to that of a disease state, regardless of whether or not there is a verifiable genetic influence. It can be extended to patients with other forms of heart disease that share the same physical condition. For example, during diastole... An effective treatment for HCM, by improving ventricular relaxation, is characterized by diastolic dysfunction. It may also be effective in a broader population. The compounds of the present invention or their pharmaceutically effective Acceptable salts may specifically target the underlying causes of these conditions, or other underlying causes. It can act on the pathway of flow. Therefore, the compounds of the present invention or their pharmaceutically acceptable salts are , suffering from diastolic heart failure with preserved ejection fraction, ischemic heart disease, angina pectoris, or restrictive cardiomyopathy It can also benefit patients. The compounds of the present invention or their pharmaceutically acceptable salts are also , volume or pressure overload (e.g., chronic mitral regurgitation, chronic aortic stenosis, or chronic Healthy ventricular remodeling in left ventricular hypertrophy caused by systemic hypertension, by volume or pressure Treatment aimed at correcting or mitigating the main cause of overload (valve repair / replacement, effective) It can be promoted in conjunction with antihypertensive treatment. By lowering left ventricular filling pressure, the compound It may reduce the risk of pulmonary edema and respiratory failure. It may reduce or eliminate functional mitral regurgitation. , and / or lowering left atrial pressure may reduce the risk of paroxysmal or persistent atrial fibrillation. This can reduce the risk of cerebral arterial embolic stroke, including but not limited to cerebral arterial embolic stroke. It also reduces the associated risk of thromboembolic complications. Dynamic and / or static left ventricular flow Reducing or eliminating outflow obstruction comes with the associated risks of short-term and long-term complications. This may reduce the likelihood of needing either surgical or percutaneous septal reduction therapy. The compound or its pharmaceutically acceptable salts reduce the severity of chronic ischemic conditions associated with HCM. This can lead to sudden cardiac death (SCD) in patients with implantable cardioverter-defibrillators. or the risks of its equivalent (frequent and / or repetitive ICD discharge), and / or This may reduce the need for potentially toxic antiarrhythmic drugs. The compound or its pharmaceutically acceptable Possible salts have associated potential toxicity, drug interactions, and / or side effects. It may be useful in reducing or eliminating the need for medication. Compounds or their pharmaceuticals A moderately acceptable salt reduces interstitial cardiomyopathy and / or slows its progression. This can stop or reverse left ventricular hypertrophy. definition

[0016] Unless otherwise defined, all technical and scientific terms used herein are the same as those used in this document. has the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure pertains.

[0017] As used in this specification and the claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. an," and "the" include plural referents unless the context clearly dictates otherwise. include plural referents unless the context clearly dictates otherwise.

[0018] The term "C x~y " or "C x ~C y " (e.g., when used with a chemical moiety such as alkyl, alkenyl, or alkynyl) means a group containing some carbon atoms from x or more carbon atoms to y or fewer carbon atoms of that chemical moiety, provided the following. The term "C " or "C ~C " does not mean to limit the number of carbon atoms that can be bonded to that chemical moiety when that chemical moiety is substituted with a second chemical moiety. For example, the term "C x~y " or "C x ~C y " refers to a substituted or unsubstituted saturated hydrocarbon group containing a straight-chain alkyl group (e.g., a linear alkyl group) and a branched alkyl group containing 1, 2, 3, 4, 5, or 6 carbon atoms, and any substituent of C 1~6 alkyl can have multiple carbon atoms, whatever the number. For example, it will be understood that when C alkyl is optionally substituted with a second chemical moiety containing 2 carbon atoms, C 1~6 alkyl can contain from 1 to 8 carbon atoms. alkyl can contain from 1 to 8 carbon atoms. 1~6 alkyl is optionally substituted with a second chemical moiety containing 2 carbon atoms, C 1~6 alkyl can contain from 1 to 8 carbon atoms.

[0019] The term "Cx~y "Alkenil" and "C x~y "Alkinyl" is the same as the alkyl mentioned above, but with a length And possible substitutions are similar, but each involves at least one double or triple bond. This refers to substituted or unsubstituted unsaturated aliphatic groups that contain these groups.

[0020] "Amino" refers to the -NH2 portion.

[0021] "Cyano" refers to the -CN portion.

[0022] "Nitro" refers to the -NO2 portion.

[0023] "Oxa" refers to the -O- part.

[0024] "Oxo" refers to the O part.

[0025] "Thioxo" refers to the S portion.

[0026] "Imino" refers to the =NH part.

[0027] "Oxymo" refers to the =N-OH portion.

[0028] "Hydrazino" refers to the =N-NH2 portion.

[0029] "Alkyl" refers to a completely saturated, linear structure consisting only of carbon and hydrogen atoms (for example) In certain embodiments, this refers to a hydrocarbon moiety that is linear (or branched, e.g., nonlinear). And, "alkyl" contains 1 to 15 carbon atoms (for example, C1 to C15 15 Alkyl) In certain embodiments, the alkyl group contains 1 to 13 carbon atoms (for example, C1- C 13 Alkyl). In certain embodiments, the alkyl group contains 1 to 8 carbon atoms. For example, C1-C8 alkyl groups. In certain embodiments, alkyl groups consist of 1 to 6 carbon atoms. Contains atoms (e.g., C1-C6 alkyl). In other embodiments, alkyl is 1- It contains 5 carbon atoms (e.g., C1-C5 alkyl). In other embodiments, alkyl The element contains 1 to 4 carbon atoms (e.g., C1 to C4 alkyl). In other embodiments, Alkyl groups contain 1 to 3 carbon atoms (e.g., C1-C3 alkyl groups). Other implementations Morphologically, alkyl groups contain one or two carbon atoms (e.g., C1-C2 alkyl groups). In other embodiments, the alkyl group contains one carbon atom (for example, C1 alkyl, For example, methyl). In other embodiments, alkyl contains 5 to 15 carbon atoms. For example, C5~C 15 Alkyl). In other embodiments, alkyl is a group of 5 to 8 carbon atoms. Contains atoms (e.g., C5-C8 alkyl). In other embodiments, alkyl is 2- It contains 5 carbon atoms (e.g., C2-C5 alkyl). In other embodiments, alkyl The element contains 3 to 5 carbon atoms (e.g., C3-C5 alkyl). In other embodiments, The alkyl groups are methyl, ethyl, 1-propyl (n-propyl), and 1-methylethyl (2-propyl, isopropyl), 1-butyl (n-butyl), 1-methylpropyl ( sec-butyl), 2-methylpropyl(iso-butyl), 1,1-dimethylethyl(t Selected from ert-butyl and 1-pentyl (n-pentyl). The alkyl is, It attaches to the rest of the molecule via a single bond.

[0030] "Aminoalkyl" is in the form of -N(H)(alkyl) or N(alkyl)(alkyl). This refers to the part that is bonded via the nitrogen atom, and that part is N(alkyl)(alkyl). In that case, the two alkyl groups bonded to the nitrogen are different even if they are the same alkyl group. Lukil base ramen.

[0031] "Alkoxy" is a compound of the formula -O-alkyl (alkyl is as defined above). This refers to the part of a chain that is bonded via an oxygen atom.

[0032] "Alkenyl" is a linear (e.g., linear) or segmental molecule consisting only of carbon and hydrogen atoms. A branched (e.g., nonlinear) hydrocarbon moiety, wherein the moiety comprises at least one carbon- This refers to a portion containing a carbon double bond. In certain embodiments, the alkenyl is 2 It contains ~12 carbon atoms. In certain embodiments, the alkenyl contains 2 to 8 carbon atoms. It contains a child. In other embodiments, the alkenyl contains 2 to 4 carbon atoms. The molecule is bonded to the rest of the molecule by a single bond, for example, ethenyl (e.g., vinyl), pro Per-1-enyl (e.g., allyl), buta-1-enyl, penta-1-enyl, penta- These include 1,4-dienyl groups.

[0033] "Alkynnyl" is a linear (e.g., linear) or segmental molecule consisting only of carbon and hydrogen atoms. A branched (e.g., nonlinear) hydrocarbon moiety, wherein the moiety comprises at least one carbon- This refers to a portion containing a carbon triple bond. In some embodiments, the alkynyl is , containing 2 to 12 carbon atoms. In some embodiments, the alkynyl is used as needed. And further contains at least one carbon-carbon double bond. In certain embodiments In other embodiments, the alkynyl contains 2 to 8 carbon atoms. It contains ~6 carbon atoms. In other embodiments, the alkynyl contains 2~4 carbon atoms. It includes. Alkynnyls are attached to the rest of the molecule by single bonds, for example, ethynyl, propinyl Examples include ru, butynyl, pentynyl, and hexynyl.

[0034] "Alkylene" or "alkylene chain" can be linear (e.g., straight) or branched (e.g. For example, it refers to the nonlinear (divalent) hydrocarbon portion. "Alkylene" or "alkylene chain" is A part of the molecule can be linked to the second part. "Alkylene" or "Alkylene A "chain" consists only of carbon and hydrogen atoms (without atoms other than hydrogen such as N, O, and S). Substitution of alkylene at one or more substituents can be specified. Alternatively, the "alkylene chain" does not need to contain unsaturated molecules (alkylene to the rest of the molecule) (Even if it is a bonding point). In certain embodiments, "alkylene" or "alkyl A "polymer chain" contains 1 to 12 carbon atoms, for example, methylene, ethylene, propylene, n-butylene, etc. The alkylene chain is attached to a part of the molecule via a single bond. It can bond to the second part via a single bond. To the rest of the molecule and the second part The bonding points of the alkylene chain can be mediated by one carbon atom within the alkylene chain, Alternatively, it can be via any two carbon atoms within the alkylene. In a particular embodiment In this context, alkylenes contain 1 to 8 carbon atoms (for example, C1-C8 alkylenes). In other embodiments, the alkylene contains 1 to 5 carbon atoms (for example, C1 to C5 Alkylene). In other embodiments, the alkylene contains 1 to 4 carbon atoms (for example) In other embodiments, the alkylene is a C1-C4 alkylene. Includes (e.g., C1-C3 alkylenes). In other embodiments, alkylene is 1 ~Contains 2 carbon atoms (e.g., C1-C2 alkylene). In other embodiments, A Lukilen contains one carbon atom (e.g., C1 alkylene). In other embodiments, Alkylenes contain 5 to 8 carbon atoms (e.g., C5-C8 alkylenes). In application, alkylenes contain 2 to 5 carbon atoms (for example, C2-C5 alkyl (Lene). In other embodiments, the alkylene contains 3 to 5 carbon atoms (for example, C 3-C5 alkylenes).

[0035] "Alkenylene" or "alkenylene chain" can be linear (e.g., straight) or branched. It refers to the divalent hydrocarbon portion of a molecule. "Alkenylene" or "alkenylene chain" is a part of a molecule. The part can be connected to the second part. "Alkenylene" or "Alkenylene chain" , consisting only of carbon and hydrogen atoms (containing atoms other than hydrogen such as N, O, and S) Substitutions of alkenylenes at multiple substituents may be specified. The “alkenylene chain” contains at least one carbon-carbon double bond. Specific embodiments In this context, "alkenylene" or "alkenylene chain" contains 2 to 12 carbon atoms. The alkenylene chain is attached to part of the molecule via one single bond, and via one single bond It can bind to the second part. The alkenylene chain to the rest of the molecule and the second part The bonding site is via one carbon atom in the alkenylene chain, or any of the carbon atoms in the alkenylene chain It can exist via any two carbon atoms. In certain embodiments, alkeni Lenene contains 2 to 8 carbon atoms (e.g., C2-C8 alkenylene). Other embodiments In this context, alkenylenes contain 2 to 5 carbon atoms (for example, C2-C5 alkenylenes). (n). In other embodiments, the alkenylene contains 2 to 4 carbon atoms (for example, C (2-C4 alkenylene). In other embodiments, the alkenylene is composed of 2-3 carbon atoms. Includes (for example, C2-C3 alkenylenes). In other embodiments, alkenylenes are It contains 5 to 8 carbon atoms (e.g., C5-C8 alkenylenes). In other embodiments, Alkenylenes contain 2 to 5 carbon atoms (e.g., C2-C5 alkenylenes). In the embodiment, the alkenylene contains 3 to 5 carbon atoms (for example, C3 to C5 Alkenylene).

[0036] "Alkynylene" or "Alkynylene chain" can be linear (e.g., straight) or branched. It refers to the divalent hydrocarbon portion of a molecule. "Alkynylene" or "Alkynylene chain" is a part of a molecule. The part can be connected to the second part. "Alkynylene" or "Alkynylene chain" , consisting only of carbon and hydrogen (with one atom other than hydrogen, such as N, O, and S) (Alternative substitutions of alkynylene with multiple substituents can be identified). "Alkynylene" or " An "alkynylene chain" contains at least one carbon-carbon triple bond. In certain embodiments... Furthermore, "alkynylene" or "alkynylene chain" contains 2 to 12 carbon atoms. The rukinylene chain is attached to part of the molecule via one single bond and to a second single bond via one single bond. It can bind to this part. Binding of the alkynylene chain to the rest of the molecule and the second part. The point is either through one carbon atom in the alkynylene chain, or within the alkynylene chain. It can exist via two carbon atoms. In certain embodiments, alkynylene It contains 2 to 8 carbon atoms (e.g., C2-C8 alkylene). In other embodiments, Alkynylenes contain 2 to 5 carbon atoms (for example, C2-C5 alkylenes). In other embodiments, the alkynylene contains 2 to 4 carbon atoms (for example, C2- (C4 alkynylene). In other embodiments, the alkynylene contains 2 to 3 carbon atoms. (For example, C2-C3 alkynylenes). In other embodiments, there are two alkynylenes. Contains carbon atoms (e.g., C2 alkynylene). In other embodiments, alkynylene It contains 5 to 8 carbon atoms (e.g., C5-C8 alkylene). In other embodiments, Alkynylenes contain 3 to 5 carbon atoms (for example, C3-C5 alkylenes). .

[0037] The term "carbo-ring," as used herein, means a saturated or non-saturated ring in which each atom of the ring is carbon. It refers to a saturated (e.g., aromatic or unaromatically unsaturated) ring or ring system. The term "carbocyclic ring" is, Includes "aryl," "cycloalkenyl," and "cycloalkyl." For example, terms "Carbon rings" include monocyclic rings with 3 to 12 members (for example, monocyclic rings with 3 to 10 members) and 4 ~20-membered polycyclic ring systems (e.g., 5-15 membered spiropolycyclic ring systems, 5-15 membered bridged polycyclic ring systems) Examples include cyclic ring systems (or fused polycyclic ring systems with 4 to 15 members). For example, as a carbocyclic ring, Bicyclic rings with 4 to 15 members (e.g., spirodicyclic rings with 5 to 15 members, bridged bicyclic ring systems with 5 to 15 members) Examples include, or condensed bicyclic ring systems with 4 to 15 members. For example, as a carbocyclic ring, bridged, Examples include tricyclic ring systems that can be condensed, spiro, or a combination thereof. For example, carbon Examples of rings include tetracyclic ring systems that can be bridged, condensed, spiro, or combinations thereof. For example, as a carbon ring, there are condensed and bridged ring systems, and condensed and spiro A ring system that is bridged and spiro, and a ring system that is condensed and bridged and spiro Another example is the polycyclic carbocyclic system. Each ring in a polycyclic carbocyclic system can be saturated or unsaturated (for example, aromatic A group or non-aromatic unsaturated ring may be selected. In exemplary embodiments, a polycyclic carbon Aromatic rings of a ring, such as phenyl, are saturated or unsaturated rings (e.g., cyclohexane, cyclo It can be condensed with pentane, cyclohexene, or phenyl. As a polycyclic carbocyclic, As long as the price allows, the choice of saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings. Examples of such combinations include polycyclic carbon rings, spirodicyclic rings, and spiropene rings. It can be a tan. For example, as a polycyclic carbocyclic ring, there is a 2-2 spiro ring system (for example, spiro[ 2.2] Pentane), 3-3 spiro ring system, 4-4 spiro ring system, 4-5 fused ring system (for example, Bicyclo[4.5.0] condensed ring system), 5-5 condensed ring system, 5-6 condensed ring system, 6-6 condensed ring system (For example, naphthalene), 5-7 condensed ring system, 6-7 condensed ring system, 5-8 condensed ring system, and 6 Examples include any combination of ring sizes, such as the -8 fused ring system. Cyclopentyl, cyclohexyl, cyclohexenyl, adamantyl, phenyl, y Danyl, naphthyl, trans-bicyclo[4.4.0]decane, cis-bicyclo[4 .4.0] Decane, spiro[3.4]octane, fluorantene, and bicyclo[1. 1.1] Pentanyl is one example.

[0038] The term "aryl" refers to a delocalized (4n) ring of at least one ring that follows Hückel's law. +2) Refers to an aromatic monocyclic or aromatic polycyclic hydrocarbon ring system containing a π electron system, where n is , an integer equal to or greater than 0. In some embodiments, aromatic Monocyclic or polycyclic aromatic hydrocarbon ring systems contain only hydrogen and carbon atoms. In that embodiment, the aromatic monocyclic or polycyclic system contains 3 to 20 carbon atoms. In some embodiments, at least one of the rings in the polycyclic aromatic ring system is aromatic. In some embodiments, aromatic monocyclic or aromatic polycyclic hydrocarbon ring systems are used. It includes a delocalized (4n+2)π electron system of a ring that follows Kell's rule. In some embodiments... And, although not limited to them, the ring systems in which the aryl group is derived include benzene, Examples include fluorene, indan, indene, anthracene, tetralin, and naphthalene. It includes a group. In some embodiments, the aryl substituent is uncharged (e.g. For example, it is neutral. In some embodiments, the aryl substituent carries a charge. No. In some embodiments, the aryl substituent does not carry a net charge. In some embodiments, the aryl substituent does not carry a net charge and is a zwitter ion. It is not ionized. In some embodiments, any carbon atom of the aryl substituent is charged It is not charged. In some embodiments, any carbon atom of the aryl substituent is charged It's not powered.

[0039] The term "cycloalkyl" refers to a saturated ring in which each atom of the ring is carbon. For example, monocyclic rings with 3 to 10 members, bicyclic rings with 5 to 12 members, spirodicyclic rings with 5 to 12 members, and Examples include monocyclic and polycyclic rings such as 5- to 12-membered bridging rings. In this embodiment, the cycloalkyl group contains 3 to 10 carbon atoms. In other embodiments, cycloalkyl A cycloalkyl group contains 3 to 7 carbon atoms. In other embodiments, a cycloalkyl group is... It contains 5 to 7 carbon atoms. Cycloalkyls can be bonded to the rest of the molecule by single bonds. Examples of monocyclic cycloalkyl groups include, for example, cyclopropyl, cyclobutyl, and cyclo Examples include pentyl, cyclohexyl, cycloheptyl, and cyclooctyl. (Polycyclic) Examples of cycloalkyl compounds include, but are not limited to, adamantyl and spi. Lopentan, norbornyl (e.g., bicyclo[2.2.1]heptanil), dekalinyl ,7,7-dimethylbicyclo[2.2.1]heptanyl, bicyclo[1.1.1]pentany Examples include ru, spiropentan, etc.

[0040] The term "cycloalkenyl" refers to a ring where each atom is carbon, and there is a small amount of carbon between the two ring carbon atoms. This refers to a saturated ring containing at least one double bond. Cycloalkenyls have 3 to 10 members. Monoring rings and biring rings with 4 to 12 members (for example, 5 to 12-membered bridging biring rings, 4 to 12 Monocyclic and polycyclic rings such as condensed bicyclic rings with 5 to 12 members, and spiro-dicyclic rings with 5 to 12 members. These are some examples. In other embodiments, the cycloalkenyl contains 5 to 7 carbon atoms. Hmm. Cycloalkenyls can be attached to the rest of the molecule by single bonds. Monocyclic cycloalkenyl Examples of "nyl" include, for example, cyclopentenyl, cyclohexenyl, cycloheptenyl, Examples include cyclooctenyl.

[0041] The term "halo," or "halogen" or "halide," refers to fluoro, chloro, and bro. It means mo or iodine. In some embodiments, halo means fluoro, chloro, or bromo. In some embodiments, the halo is fluoro or chloro. In some embodiments, the halo is fluoro. In some embodiments, Haro is Chloro.

[0042] The term "haloalkyl" refers to a compound that is substituted with one or more halogens, as previously defined. Alkyl compounds as defined, for example, trifluoromethyl, dichloromethyl, bromomethyl This refers to 2,2,2-trifluoroethyl, 1-chloromethyl-2-fluoroethyl, etc. In some embodiments, the alkyl portion of the haloalkyl is as described herein. As needed, further substitutions are made.

[0043] The term "heterocyclic ring," as used herein, refers to a ring formed by one or more heteroatoms. is a saturated or unsaturated (e.g., aromatic or non-aromatic unsaturated) ring or ring that is a member of a ring system. This refers to a system. Examples of heteroatoms include N, O, Si, P, B, and S atoms. For example, as a complex ring, a monoring ring with 3 to 12 members (for example, a monoring ring with 3 to 10 members) ) and polycyclic ring systems with 4 to 20 members (e.g., condensed polycyclic ring systems with 4 to 15 members, 5 to 15 members) Examples include polycyclic ring systems and 5-15 membered bridging polycyclic ring systems. For example, as a heterocyclic ring For example, bicyclic ring systems with 4 to 20 members (for example, condensed bicyclic ring systems with 4 to 15 members, 5 to 15 members) Examples include pyronidic ring systems and 5-15 member bridged bicyclic ring systems. For example, a heterocycle and Examples include tricyclic ring systems that may be bridged, condensed, spiro, or combinations thereof. For example, as a heterocycle, a tetracycle could be a bridge, condensation, spiro, or a combination thereof. Examples include ring systems. For instance, as heterocycles, there are condensed and bridged ring systems, and condensed rings. Ring systems that are both fused and spiro, ring systems that are both bridged and spiro, and condensed and bridged Examples include ring systems that are also spiros. Each ring in a polycyclic heterocycle can be saturated or unsaturated. (For example, aromatic or unaromatic unsaturated) rings can be selected. As for polycyclic heterocycles, As long as the bond valency allows, saturated and unsaturated (e.g., aromatic or non-aromatic unsaturated) rings Any combination is possible. In exemplary embodiments, an aromatic ring, for example, pyridyl or Phenyl is a heteroatom insofar as at least one atom of the resulting fused ring system is a heteroatom. In this context, saturated or unsaturated rings, such as cyclohexane, cyclopentane, and morpholine, are used. It can be condensed to piperidine or cyclohexene. As a polycyclic heterocycle, it can be 3-3 spin b, 4-5 condensed ring system, 5-5 condensed ring system, 5-6 condensed ring system, 6-6 condensed ring system, 5-7 condensed ring A system of arbitrary ring size, such as a 6-7 fused ring system, a 5-8 fused ring system, and a 6-8 fused ring system. The following combinations can be given. As for biring heteroalgebras, further, spiro diringalgebras, for example 5-1 Examples include two-membered spirodicyclic rings, such as 2-oxa-6-azaspiro[3.3]heptane. In some embodiments, the heterocycle includes multiple heteroatoms. In its form, the heterocycle contains atoms selected from nitrogen, oxygen, and sulfur. In the embodiment, the heterocycle comprises multiple atoms selected from nitrogen, oxygen, and sulfur. In some embodiments, the heterocycle is one selected from nitrogen, oxygen, and sulfur. Or it contains more atoms. In some embodiments, the heterocycle contains nitrogen and It contains one or more atoms selected from oxygen. In some embodiments A heterocycle contains one or more atoms selected from nitrogen and sulfur. In several embodiments, the heterocycle is one or more selected from oxygen and sulfur. It contains many atoms. In some embodiments, the heterocycle is one selected from nitrogen. or it contains more atoms. In some embodiments, the heterocycle is selected from oxygen. It contains one or more atoms. In some embodiments, the heterocycle is It contains one or more atoms selected from sulfur. An example of a non-restrictive heterocycle. These are pyridine, pyrrole, indole, carbazole, piperidine, oxazole, and molar. Forine, thiophene, benzothiophene, furan, tetrahydrofuran, and pyran Examples include non-restrictive heterocyclic compounds such as azepinyl, acridinyl, and benzimida. Zolyl, benzoindolyl, 1,3-benzodioxolyl, benzofuranyl, benzox Sazolil, Benzo[d]thiazolyl, Benzothiadiazolyl, Benzo[b][1,4]di Oxepinyl, Benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, Be Nzonaphthofuranil, benzoxazolyl, benzodioxolyl, benzodioxynil, Benzopyranil, benzopyranonil, benzofuranil, benzofuranonil, benzothien (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriaz Lil, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnorinyl , cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5 ]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5 ,6-dihydrobenzo[h]sinnolinyl, 6,7-dihydro-5H-benzo[6,7] Cyclohepta[1,2-c]pyridazinyl, dibenzofuranil, dibenzothiophenyl, Furacil, Furanonyl, Flo[3,2-c]pyridinyl, 5,6,7,8,9,10-he Xahydrocycloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydro Cycloocta[d]pyridazinyl, 5,6,7,8,9,10-hexahydrocyclooc Ta[d]pyridinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, in Dazolyl, isoindolyl, indolinyl, isoindolinyl, isoquinolyl, indri Dinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolin Naphthilidinyl, 1,6-Naphthilidinol, Oxadiazolyl, 2-Oxoazepi Nyl, oxazolyl, oxyranil, 5,6,6a,7,8,9,10,10a-octa Hydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, phenazinyl, phen Nothiazinil, phenoxazinil, phthalazinil, pteridinil, prinil, pyrrolyl, Pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, pyrido[3,2-d] Pyrimidinyl, pyrido[3,4-d]pyrimidinyl, pyrazinyl, pyrimidinyl, pyrida Dinyl, pyrrolyl, quinazolinyl, quinoxalinyl, quinolinyl, isoquinolinyl, teto Lahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-te Trahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl, 6,7,8,9-teto Lahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidinyl, 5,6, 7,8-Tetrahydropyrido[4,5-c]pyridazinyl, thiazolyl, thiadiazolyl , triazolyl, tetrazolyl, triazinyl, thieno[2,3-d]pyrimidinyl, thieno[2,3-d]pyrimidinyl Eno[3,2-d]pyrimidinyl, thieno[2,3-c]pyrimidinyl, and thiophene Examples include 'Lu' (for instance, 'Tienil').

[0044] In some embodiments, the heterocycle is bonded to the molecule by carbon atoms. In some embodiments, the heterocycle is bonded to the molecule by a nitrogen atom.

[0045] In some embodiments, the heterocycle is a heteroaryl, heterocycloalkyl, or It includes a portion selected from and heterocycloalkenyl. In some embodiments, The heterocycle is a heteroaryl. In some embodiments, the heterocycle is a heterocycloaryl. It is a lukyl. In some embodiments, the heterocycle is a heterocycloalkenyl.

[0046] In some embodiments, the heterocycle comprises atoms selected from nitrogen and oxygen. In some embodiments, the heterocycle contains atoms selected from nitrogen and sulfur. In some embodiments, the heterocycle contains atoms selected from oxygen and sulfur. In some embodiments, the heterocycle contains an atom selected from nitrogen. In this state, the heterocycle contains an atom selected from oxygen. In some embodiments, Heterocyclic rings contain atoms selected from sulfur.

[0047] In some embodiments, the heterocycle contains 1 to 8 heteroatoms. In the embodiment, the heterocycle contains 1 to 5 heteroatoms. In some embodiments, The heterocycle contains 1 to 3 heteroatoms. In some embodiments, the heterocycle is 1 It contains ~2 heteroatoms. In some embodiments, the heterocycle contains 1 heteroatom It includes. In some embodiments, the heterocycle contains two heteroatoms. In some embodiments, the heterocycle contains three heteroatoms. In some embodiments, The heterocycle contains four heteroatoms. In some embodiments, the heterocycle contains five heteroatoms. It contains heteroatoms. In some embodiments, the heterocycle contains six heteroatoms.

[0048] In some embodiments, the heteroring is a 3-membered ring, a 4-membered ring, a 5-membered ring, a 6-membered ring, a 7-membered ring, 8-membered ring, 9-membered ring, 10-membered ring, 11-membered ring, 12-membered ring, 13-membered ring, 14-membered ring, or 15-membered ring... It includes a 20-membered ring. In some embodiments, the heterocycle has 3 to 10 members. In some embodiments, the complex ring has 3 to 6 members. The ring has 5 to 6 members. In some embodiments, the complex ring has 9 to 10 members. In some embodiments, the complex ring has 9 to 11 members. In some embodiments, Complex algebras have 9 to 15 members.

[0049] In some embodiments, the heterocycle is monosubstituted, disubstituted, trisubstituted, tetrasubstituted, or pentassubstituted. Substituting (for example, with additional substituents in addition to the bond site). In some embodiments... Furthermore, substituents on a heterocycle (for example, those bonded to the ring of a heterocycle) (for example, atoms other than hydrogen) The total number of children is 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10. Or, or more than that.

[0050] In some embodiments, in a molecule or part (for example, in a heterocycle), One or more nitrogen atoms, if present, may be quaternized as needed. In some embodiments, the heterocyclic substituent is positively charged. The heterocyclic portion is neutral. In some embodiments, the heterocyclic substituent is a zwitterion. In some embodiments, the heterocyclic substituent is a property, and as an alternative or addition, , uncharged. In some embodiments, the heterocyclic substituent does not carry a charge. In some embodiments, the heterocyclic substituent does not carry a net charge. In that embodiment, none of the atoms in the heterocyclic substituent carry a net charge. In some embodiments, the heterocyclic substituent does not carry a net charge and is a zwitterion. It's not a gender. The term "heteroaryl" refers to a ring system in which one or more heteroatoms are members. , a delocalized ring (4n+2)π-electric ring system in which at least one ring system obeys Hückel's law This refers to a part derived from an aromatic monocyclic or aromatic polycyclic ring system, including its subsystems, where n is an integer equal to or greater than 0. In some embodiments, one Or more heteroatoms constitute a delocalized cyclic (4n+2)π-electron system of the ring. It is a member of a ring system (for example, an aromatic ring). Exemplary heteroatoms include: Examples include N, O, Si, P, B, and S atoms. In some embodiments, hete Roaryl is a group of heteroatoms, each containing one or more heteroatoms. One or more non-aromatic compounds that may or may not contain many heteroatoms. The group includes aromatic rings, which are members of a ring system into which the rings can condense. In some embodiments, the hete Roaryl contains one or more heteroatoms selected from nitrogen, oxygen, and sulfur. In some embodiments, the heteroaryl is selected from nitrogen, oxygen, and sulfur. It contains multiple heteroatoms. In certain embodiments, the "heteroaryl" is 3- Includes rings and ring systems containing 20 atoms. In some embodiments, "heteroary "Lu" consists of 2 to 17 carbon atoms, as well as 1 to 6 atoms selected from nitrogen, oxygen, and sulfur. Includes rings and ring systems containing heteroatoms. When used herein, the heteroaryl portion A fraction is a monocyclic or polycyclic (e.g., bicyclic, tricyclic, or tetracyclic) ring system, In this ring system, at least one of the rings is aromatic, for example, the non-aromatic ring in a ring system that follows Hückel's rule. It contains a localized (4n+2)π electron system. As heteroaryls, it includes condensed ring systems and bridged rings. Examples include ring systems and spiro ring systems. The heteroatoms (or heteroatoms) of the heteroaryl moiety are: Oxidized as needed. One or more nitrogen atoms, if present, are tetraoxidized as needed. Classification occurs. Heteroaryls are bonded to the rest of the molecule via any atom in the ring. Examples of aryl compounds, though not limited to these, include acridinil and benzimida. Zolyl, benzoindolyl, 1,3-benzodioxolyl, benzofuranyl, benzox Sazolil, Benzo[d]thiazolyl, Benzothiadiazolyl, Benzo[b][1,4]di Oxepinyl, Benzo[b][1,4]oxazinyl, 1,4-benzodioxanyl, Be Nzonaphthofuranil, benzoxazolyl, benzodioxolyl, benzodioxynil, Benzopyranil, benzopyranonil, benzofuranil, benzofuranonil, benzothien (benzothiophenyl), benzothieno[3,2-d]pyrimidinyl, benzotriaz Lil, benzo[4,6]imidazo[1,2-a]pyridinyl, carbazolyl, cinnorinyl , cyclopenta[d]pyrimidinyl, 6,7-dihydro-5H-cyclopenta[4,5 ]thieno[2,3-d]pyrimidinyl, 5,6-dihydrobenzo[h]quinazolinyl, 5 ,6-dihydrobenzo[h]sinnolinyl, 6,7-dihydro-5H-benzo[6,7] Cyclohepta[1,2-c]pyridazinyl, dibenzofuranil, dibenzothiophenyl, Furanil, Flo[3,2-c]pyridinyl, 5,6,7,8,9,10-hexahydrocy Chloocta[d]pyrimidinyl, 5,6,7,8,9,10-hexahydrocycloocta [d] Pyridazinyl, 5,6,7,8,9,10-Hexahydrocycloocta[d] Pyridazinyl Dinyl, isothiazolyl, imidazolyl, indazolyl, indolyl, isoindolyl Indolinyl, isoindolinyl, isoquinolyl, indolidinyl, isoxazolyl, 5,8-methano-5,6,7,8-tetrahydroquinazolinyl, naphthilidinyl, 1,6 - Naphthyridinonyl, oxadiazolyl, oxazolyl, 5,6,6a,7,8,9,1 0,10a-Octahydrobenzo[h]quinazolinyl, 1-phenyl-1H-pyrrolyl, Phenazinyl, phenothiazinyl, phenoxadinyl, phthalazinyl, pteridinyl, p Linyl, pyrrolyl, pyrazolyl, pyrazolo[3,4-d]pyrimidinyl, pyridinyl, py Lido[3,2-d]pyrimidinil, pyrido[3,4-d]pyrimidinil, pyrazinil, pi Limidinil, Pyridazinil, Pyrrolyl, Quinazolinil, Quinoxalinil, Quinolinil, I Soquinolinyl, tetrahydroquinolinyl, 5,6,7,8-tetrahydroquinazolinyl, 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinyl, 6 ,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyri Midinyl, 5,6,7,8-tetrahydropyrido[4,5-c]pyridazinyl, thiazoly Lu, thiadiazolyl, triazolyl, tetrazolyl, triazinyl, thieno[2,3-d Pyrimidinyl, thieno[3,2-d]pyrimidinyl, thieno[2,3-c]pyrimidinyl Examples include , and thiophenyl (e.g., thienyl). In some embodiments, A further example of a "heteroaryl" is 5,6,7,8-tetrahydroquinoline; 1,2,3,4-Tetrahydro-1,8-Naphthyridine; 6,7-Dihydro-5H-Cyc lopenta[b]pyridine; 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine; 4 ,5,6,7-tetrahydrobenzofuran;4,5,6,7-tetrahydrofuran[2,3 -b]pyridine; 5,6-dihydro-4H-cyclopenta[b]furan; 4,5-dihydro Examples include rotieno[2,3-b]furan. The substituents are positively or negatively charged. In some embodiments, heterozygous The substituent is neutral. In some embodiments, the heteroaryl substituent is zwitteraryl It is on-type, and in some embodiments, as an alternative or addition, hetero-alien The heteroaryl substituent is uncharged. In some embodiments, the heteroaryl substituent is , does not carry charge. In some embodiments, the heteroaryl substituent is net It does not carry charge. In some embodiments, the heteroaryl substituent has a net charge It is neither load-bearing nor zwitterionic.

[0051] The term "heterocyclic ring" is derived from "heteroaryl," "heterocycloalkenyl," and "hetero." Contains "rocycloalkyl"

[0052] The term "heterocycloalkyl" refers to a saturated ring (for example, a ring in which the members of the ring are connected). A portion containing a ring whose bonds consist only of single bonds, where this saturated ring consists of carbon atoms (or more) It contains one or more heteroatoms as members of a saturated ring, and this saturated ring is Even if it condenses into a further ring as needed, or bridges to a further ring, It may also be a spiro, and this further ring may have multiple carbon atoms as members of the further ring This may include, or this further ring may have one or more members as further rings. A part that may contain a number of heteroatoms. In some embodiments, a heterocycloa Lukil can be covalently bonded to one or more carbon rings or heterocycles. Exemplary examples include... Examples of heteroatoms include N, O, Si, P, B, and S atoms. Lukil consists of monocyclic rings with 3-10 members, bicyclic rings with 6-12 members, and spironi with 5-12 members. Examples include monocyclic and polycyclic rings, such as rings or bridging rings with 5 to 12 members. The heteroatoms of the chloroalkyl group are oxidized as needed. One or more nitrogen atoms If present, quaternization is performed as needed. Heterocycloalkyls have acceptable bond values. If so, any atom of the heterocycloalkyl, for example, any carbon of the heterocycloalkyl Alternatively, it can bond to the rest of the molecule via a nitrogen atom. Examples of heterocycloalkyl groups include... This is not limited to dioxolanil, thienyl[1,3]dithianil, deca Hydroisoquinolyl, imidazolinyl, imidazolidinyl, isothiazolidinyl, iso Quizazolidinyl, Morpholinyl, Octahydroindolyl, Octahydroisoindolyl , 2-oxopiperazinil, 2-oxopiperidinil, 2-oxopyrrolidinil, oxa Zolidinyl, piperidinyl, piperazinyl, 4-piperidonyl, pyrrolidinyl, pyrazoli Dinyl, quinuclidinyl, thiazolidinyl, tetrahydrofuryl, trithianil, tetra Hydropyranil, thiomorpholinil, thiamorpholinil, 1-oxo-thiomorpholinil , 2-oxa-6-azaspiro[3.3]heptane, and 1,1-dioxo-thiomol One example is folinyl. In some embodiments, the heterocycloalkyl is one Contains heteroatoms. In some embodiments, the heterocycloalkyl is N, O, It contains one heteroatom selected from and S. In some embodiments, the heteros The chloroalkyl group contains multiple heteroatoms. In some embodiments, heterocyclo Alkyl compounds contain multiple heteroatoms selected from N, O, and S.

[0053] The term "heterocycloalkenyl" refers to an unsaturated ring (for example, a ring formed by linking its members together). A portion containing a ring having single or double bonds, wherein this unsaturated ring has multiple carbon It contains atoms and one or more heteroatoms, and this unsaturated ring is required to form a further ring. Even if they are condensed as needed, or bridged with further rings, or spiro to further rings It may exist, and this further ring may contain only multiple carbon atoms as members of the further ring. Or, this further ring may have one or more heterogens as members of the further ring. It may contain children; and at least one double bond is between two ring carbon atoms (for example, this unsaturated) This refers to the part that exists between the carbon atoms that are members of the ring. Heterocycloalkenyls are heterocycloalkenyls. The loaryl ring is not included. Exemplary heteroatoms include N, O, Si, P, B, and Examples include S atoms. Heterocycloalkenyls include monocyclic rings with 3 to 10 members, and 6- Examples include 12-membered biring rings and monoring and polyring rings such as 5- to 12-membered bridging rings. In other embodiments, the heterocycloalkenyl contains 5 to 7 ring atoms. Telohcycloalkenyls can be attached to the rest of the molecule by single bonds. Monocyclic cycloalkenyls Examples of nyl include pyrroline (dihydropyrrole) and pyrazoline (dihydropyrrole). Zole), imidazoline (dihydroimidazole), triazoline (dihydrotriazole (Lu), dihydrofuran, dihydrothiophene, oxazoline (dihydroxazole), Isoxazoline (dihydroisoxazole), thiazoline (dihydrothiazole), i Sothiazoline (dihydroisothiazole), oxadiazoline (dihydrooxadiazo (Lu), thiadiazoline (dihydrothiadiazole), dihydropyridine, tetrahydropyridine Lysine, dihydropyridazine, tetrahydropyridazine, dihydropyrimidine, tetrahydro Dropyrimidine, dihydropyrazine, tetrahydropyrazine, pyran, dihydropyran, Thiopyran, dihydrothiopyran, dioxin, dihydrodioxin, oxazine, dihi Examples include droxazine, thiazine, and dihydrothiazine.

[0054] The "Spiror ring" part (for example, the "Spiror" part) (for example, a spiro ring heterocycle, spiro Cyclic heterocycloalkenyl, spirocyclic carbon ring, spirocyclic heterocycloalkyl, A pyrocyclic cycloalkenyl (or spirocyclic cycloalkyl) is a compound in which two rings are precisely formed. These are spirocyclic systems (e.g., bicyclic, tricyclic, or tetracyclic systems) that share one atom. Examples of spiro ring structures include: [ka] These include, but are not limited to, the following:

[0055] A spirocyclic heterocycle contains at least one heteroatom in the ring system of the spirocyclic portion. , including a spirocyclic part. Examples of spirocyclic heterocyclic rings include: [ka] These include, but are not limited to, the following:

[0056] A spirocyclic carbon ring is a ring system in which only carbon atoms are contained within the spirocyclic portion. Includes minutes. Examples of spirocyclic carbocyclic rings include: [ka] These include, but are not limited to, the following:

[0057] The "condensed" part (for example, a condensed heterocycle, a condensed carbon ring, a condensed heterocycloalkyl, or A condensed cycloalkyl group is a polycyclic system in which two rings share exactly two atoms (e.g., Examples include biring, triring, and tetraring structures. Examples of condensed parts include: [ka] These include, but are not limited to, the following:

[0058] A "condensed" heterocycle is a condensed ring that contains at least one heteroatom in the ring system of the condensed portion. This includes: Examples of condensed complex algebras include: [ka] These include, but are not limited to, the following:

[0059] A "condensed" carbon ring contains a condensed portion that consists only of carbon atoms within the ring system of this condensed portion. Examples of elementary algebras include: [ka] These include, but are not limited to, the following:

[0060] The "bridged" part (for example, bridged heterocycle, bridged carbocycle, bridged heterocycloalkyl, bridged he A telocycloalkenyl (or bridged cycloalkyl) is a compound with two or more bridges. Including the head, here in at least one combination of two bridgeheads, the combination of two bridgeheads Each bridgehead in the combination is connected to the other bridgeheads in the combination of two bridgeheads by three bridges They are separated, and each bridge contains at least one atom, and each of these three bridges contains the other two A polycyclic system (for example, a bicyclic system) that does not contain any atoms that are the same as any of the bridges. These are three-ring and four-ring designs.

[0061] In some embodiments, the "bridged" portion (e.g., bridged heterocycle, bridged carbon ring, bridged (Heterocycloalkyl, bridged heterocycloalkenyl, or bridged cycloalkyl) , including two or more bridgeheads, where at least one pair of two bridgeheads Each bridgehead in this pair is separated from the other bridgeheads in the pair by three bridges. Each bridge contains at least one atom, and each of these three bridges contains any of the other two bridges A polycyclic system (e.g., bicyclic, tricyclic, tetracyclic) that does not contain any atoms that are the same as any of the others. )

[0062] In some embodiments, the bridgehead atom is a nexus between two or more rings. Forming sp 3 -A hybrid carbon or nitrogen atom. In some embodiments, bridges It contains one or more atoms connecting two bridgehead atoms.

[0063] Examples of bridge sections include: [ka] These include, but are not limited to, the following:

[0064] A "bridged" carbocyclic ring contains only carbon atoms in the bridged portion of the ring system. Examples of rings include: [ka] [ka] These include, but are not limited to, the following:

[0065] A "bridged" heterocycle is defined as a ring system in which the bridged portion contains at least one heteroatom, and the bridged portion contains at least one heteroatom. Includes. Examples of bridged complex algebras include: [ka] These include, but are not limited to, the following:

[0066] The term "substituted" refers to a compound having one or more carbon atoms or being replaceable. A portion having substituents that replace hydrogen on a heteroatom (e.g., NH or NH2) To refer to. "Substitution" or "substituted with," but such a substitution refers to the substituted atom and This includes the implicitly indicated condition that it is subject to the permissible bond valency of its substituents, and furthermore, its position The exchange produces stable compounds (for example, compounds that do not undergo rapid rearrangement, cyclization, or elimination). It is understood that this includes the condition that, in certain embodiments, substituted means the same A substituent that replaces two hydrogen atoms on a carbon atom (for example, on one carbon atom) The two hydrogen atoms are then connected by an oxo, imino, oxime, hydrazone, or thioxo group. Refers to the portion having (to be replaced). As used herein, the term "replaced" means having It is intended to include all acceptable substituents of the compound. In a broad sense, its allowance Acceptable substituents include acyclic and cyclic, branched and unbranched substituents of organic compounds. Examples include aromatic and non-aromatic substituents of carbocyclic and heterocyclic structures. The substituents may be one or more for a given organic compound, and may be the same or They can be different.

[0067] In some embodiments, the term “one or more substituents” means one substitution Substituting, or two substituents, or three substituents, or four substituents, or five substituents This can refer to a substituent group, or six substituents, or more than six substituents. Several implementation forms In this context, the term "one or more substituents" can refer to one substituent. In some embodiments, the term “one or more substituents” means two substituents. It may mean that. In some embodiments, the term “one or more substituents” means , can refer to three substituents. In some embodiments, the term "one or more" "four substituents" can refer to four substituents. In some embodiments, the term "one substituent" "or more substituents" could mean five substituents. In some embodiments The term "one or more substituents" can refer to five or more substituents. In some embodiments, the term "one or more substituents" means one substituent ~ It may refer to 10 substituents. In some embodiments, the term "one or more" is used. "Substituents of" may mean at least one substituent. In some embodiments, the term "One or more substituents" can mean up to 10 substituents. In application, the term "one or more substituents" means up to five substituents. It can be said. In some embodiments, the term “one or more substituents” means the most It can mean up to two substituents. In some embodiments, the term "one or more" is used. "Many substituents" can refer to one substituent to two substituents. In some embodiments... The term "one or more substituents" means one substituent, one substituent, one Substituents ~ 3 substituents, 1 substituent ~ 4 substituents, 1 substituent ~ 5 substituents, 1 1-6 substituents, 1-7 substituents, 1-10 substituents , 2-3 substituents, 2-4 substituents, 2-5 substituents Substituent group, 2-6 substituents, 2-7 substituents, 2-10 substituents substituents, 3 substituents ~ 4 substituents, 3 substituents ~ 5 substituents, 3 substituents ~ 6 substituents, 3 substituents to 7 substituents, 3 substituents to 10 substituents, 4 substitutions Group ~ 5 substituents, 4 substituents ~ 6 substituents, 4 substituents ~ 7 substituents, 4 Substituents ~ 10, 5 ~ 6, 5 ~ 7, 5 1 to 10 substituents, 6 to 7 substituents, 6 to 10 substituents , or may refer to 7 to 10 substituents. In some embodiments, the term " "One or more substituents" means one substituent, two substituents, three substituents, four substituents. This can refer to a 1 substituent, 5 substituents, 6 substituents, 7 substituents, or 10 substituents. ru.

[0068] In some embodiments, the substituent is, for example, any of the following described herein. Substituents may include: halogen, hydroxyl, oxo (=O), thioxo (=S), cyano (-CN), nitro (-NO2), imino (=NH), oxime (=N) -OH), hydrazino (=N-NH2), -R b -OR a ,-R b -OC(O)-R a , -R b -OC(O)-OR a ,-R b -OC(O)-N(R a )2, -R b -N(R a ) 2, -R b -C(O)R a ,-R b -C(O)OR a ,-R b -C(O)N(R a )2, -R b -OR c -C(O)N(R a )2, -R b -N(Ra )C(O)OR a ,-R b -N(R a )C(O)R a ,-R b -N(R a )S(O) t R a (where t is 1 or 2 (is), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t Ure a (where t is 1 or 2), and -R b -S(O) t N(R a )2(ko Here t is 1 or 2); as well as alkyl, alkenyl, alkynyl, aryl, Aralkyl, aralkenyl, aralquinyl, cycloalkyl, cycloalkylalkyl, Heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, and hetero Arylalkyls, and any of these are alkyl, alkenyl, or alkini Halo, halogen, haloalkyl, haloalkenyl, haloalkynyl, oxo(=O), thio Xo (=S), Cyano (-CN), Nitro (-NO2), Imino (=NH), Oxime (=N-OH), hydrazine (=N-NH2), -R b -OR a ,-R b -OC(O)- R a ,-R b -OC(O)-OR a ,-R b -OC(O)-N(R a )2, -R b -N( R a )2, -R b -C(O)R a ,-R b-C(O)OR a 、 -R b -C(O)N(R a )2、 -R b -O-R c -C(O)N(R a )2、 -R b -N(R a )C(O)OR a 、 -R b -N(R a )C(O)R a 、 -R b -N(R a )S(O) t R a (where t is 1 or 2), -R or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S (O) t OR a (where t is 1 or 2) and -R b -S(O) t N(R a )2 (where t is 1 or 2) may be optionally substituted; where each R a is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, he terocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroar ylalkyl, independently selected, where each R a is, if the valence allows, alkyl , alkenyl, alkynyl, halogen, haloalkyl, haloalkenyl, haloalkynyl , oxo(=O), thioxo(=S), cyano(-CN), nitro(-NO2), imino (=N-H), oxime(=N-OH), hydrazine(=N-NH2), -R b -OR a , -R b -OC(O)-R a,-R b -OC(O)-OR a ,-R b -OC(O)-N( R a )2, -R b -N(R a )2, -R b -C(O)R a ,-R b -C(O)OR a ,- R b -C(O)N(R a )2, -R b -OR c -C(O)N(R a )2, -R b -N( R a )C(O)OR a ,-R b -N(R a )C(O)R a ,-R b -N(R a )S(O) t R a (where t is 1 or 2), -R b -S(O) t R a (where t is 1 or 2), -R b -S(O) t Ure a (where t is 1 or 2) and -R b - S(O) t N(R a )2 (where t is 1 or 2) can be substituted as needed; And here are each R b These are directly bonded, or linear or branched alkylenes, alke Selected independently from nylene or alkynylene chains, and each R c is straight or These are branched alkylene, alkenylene, or alkinylene chains.

[0069] Double bonds with oxygen atoms, such as the oxo group, are referred to herein as "=O" and "(O)". It can be expressed as both. The double bond with the nitrogen atom can be expressed as both "=NR" and "(NR)". It is represented as follows. The double bond with the sulfur atom is represented as both "=S" and "(S)". ru.

[0070] The phrases “parenteral administration” and “administered parenterally” as used herein refer to enteral administration only. This means, but is not limited to, external administration and local administration, usually by injection. Intravenous, intramuscular, intraarterial, intrathecal, intraarticular, intraorbital, intracardiac, intradermal, intraperitoneal, and transhepatic Examples include intraductal, subcutaneous, subepidermal, intra-articular, subcapsular, subarachnoid, intraspinal, and intrasternal injections and infusions. It is possible.

[0071] The phrase "pharmaceutically acceptable" in this specification means, within the bounds of appropriate medical judgment, an excessive amount of poison. Human and animal tissues without sexual, irritation, allergic reactions, or other problems or complications. Compounds, materials, compositions, and Used to refer to a pill / or dosage form.

[0072] The phrases “pharmaceutically acceptable additive” or “pharmaceutically acceptable carrier” are used herein. When used, it may be used with pharmaceutically acceptable materials, compositions, or vehicles, such as liquids or solids. This refers to fillers, diluents, additives, solvents, or encapsulating materials of a formulation. Each carrier is the other of the formulation. It must be "acceptable" in the sense that it is compatible with the ingredients and not harmful to the patient. Some examples of materials that can act as pharmaceutically acceptable carriers include (1 (1) Sugars, such as lactose, glucose and sucrose; (2) Starch, such as corn. (3) Rocos starch and potato starch, cellulose and its derivatives, for example Sodium carboxymethylcellulose, ethylcellulose, and cellulose acetate, (4 ) Powdered tragacanth, (5) Malt, (6) Gelatin, (7) Talc, (8) Excipients, for example (9) Cocoa butter and suppository wax, oils such as peanut oil, cottonseed oil, safflower oil Oils, sesame oil, olive oil, corn oil and soybean oil, (10) glycol, for example, p (11) polyols, e.g., glycerin, sorbitol, mannitol (12) esters, such as ethyl oleate and polyethylene glycol, (12) esters, for example. Ethyl laurate, (13) agar, (14) buffering agent, such as magnesium hydroxide and water (15) Aluminum oxide, (16) Alginic acid, (17) Water free of exothermic substances, (18) Isotonic (18) Saltwater, (19) Ringer's solution, (20) Ethyl alcohol, (20) Phosphate buffer, (21) Other non-toxic, suitable substances used in pharmaceutical formulations are listed.

[0073] The term "salt" or "pharmaceutically acceptable salt" refers to various organic and pharmaceutically acceptable salts well known in the art. This refers to salts derived from inorganic counterions. Pharmaceutically acceptable acid addition salts are those derived from inorganic acids and / Alternatively, it can be formed using organic acids. Inorganic acids that can induce salt formation include: Examples include hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, and phosphoric acid. The ability to induce salt formation is possible. Examples of organic acids that can be produced include acetic acid, propionic acid, glycolic acid, pyruvic acid, and sulfate. Green acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, silica Pelic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, sa Examples include lysyl acid. pharmaceutically acceptable base addition salts are inorganic and / or organic salts. It can be formed using a group. Examples of inorganic bases that can derive salts include, for example, Sodium, potassium, lithium, ammonium, calcium, magnesium, iron, ammonium Examples include lead, copper, manganese, and aluminum. Organic bases that can induce salts and For example, this includes primary, secondary, and tertiary amines, as well as naturally occurring substituted amines. Subsubstituted amines, cyclic amines, basic ion exchange resins, etc., specifically isopropyl Amines, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine are examples. In some embodiments, pharmaceutically acceptable The base addition salts are ammonium, potassium, sodium, calcium, and magnesium. Selected from unsalted salt.

[0074] As used herein, “treatment” or “to treat” is not limited to the following: However, it does not include therapeutic and / or preventive benefits relating to a disease, disorder, or medical condition. This refers to a method for obtaining beneficial or desired results. Therapeutic benefits include, for example, the treatment This may include eradication or alleviation of the underlying disease. Furthermore, the therapeutic benefit may include, for example, if the subject is still at risk of developing the underlying condition. Even though the subject may have an underlying disease, improvement is observed in the subject. This may include eradicating or alleviating one or more physiological symptoms associated with the underlying disease. In a certain embodiment, the preventive benefit is that even if a diagnosis of a specific disease has not been made, In addition, the composition is used in subjects at risk of developing this disease, or in those exhibiting physiological symptoms of the disease. Administration of one or more compounds described herein. The procedure does not require the involvement of a medical professional.

[0075] Chemical entities having a carbon-carbon double bond or a carbon-nitrogen double bond are Z- or E-form It can exist in a state (or cis- or trans-form). Furthermore, in some chemical The substance may exist in various tautomeric forms. Unless otherwise specified, the forms described herein are The compounds are intended to include all Z-, E-, and tautomer forms as well.

[0076] A "tautomer" is a molecule in which a proton shift can occur from one atom of a molecule to another atom of the same molecule. This refers to molecules capable of tautomerism. The compounds presented herein, in certain embodiments, are tautomers. It exists as such. In environments where tautomerism is possible, a chemical equilibrium of tautomers exists. The exact ratio of tautomers depends on several factors, including physical conditions, temperature, solvent, and pH. It depends on the following. Some examples of tautomeristic equilibrium include: [ka] These are some examples.

[0077] The compounds disclosed herein, in some embodiments, for example, 2 H, 3 H, 11 C, 13 C and / or 14 Used in different enriched isotope forms with concentrated C content. In one particular embodiment, the compound is deuterated at at least one position. This deuterated form is described in U.S. Patent Nos. 5,846,514 and 6,3. It can be prepared by the procedure described in U.S. Patent No. 34,997. As described in issues 514 and 6,334,997, deuteration is metabolic This can improve stability and / or efficacy, and therefore increase the duration of action of the drug. ru.

[0078] Unless otherwise stated, the compounds described herein are one or more isotopes The intention is to include compounds that differ only in the presence of concentrated atoms. For example, one or Multiple protons form one or more deuterium (two hydrogen atoms) or tritium (three hydrogen atoms). The element(s), or a combination thereof, being replaced by them, or in its structure one or more 12 The carbon atom, in its structure, is one or more 13 C atom, 1 one or more 14 It is replaced by a carbon atom, or a combination thereof. Compounds having the structure of the present invention, excluding those mentioned above, are within the scope of this disclosure.

[0079] The compounds disclosed herein may optionally contain one or more atoms that make up such compounds. It contains atomic isotopes in unnatural proportions. For example, a compound may contain deuterium ( 2 H), Tritium 3 H), Iodine-125( 125 I) or carbon-14 ( 14 C) It can be labeled with one or more isotopes. 2 H, 3 H, 11 C, 13 C, 14 C, 15 C , 12 N, 13 N, 15 N, 16 N, 17 O, 18 O, 14 F,15 F, 16 F, 17 F , 18 F, 33 S, 34 S, 35 S, 36 S, 35 Cl, 37 Cl, 79 Br, 81 Br , and 125 All isotopic substitutions by I are intended. All isotopes of the compounds of the present invention The modified forms, whether radioactive or not, are included within the scope of this invention.

[0080] In certain embodiments, the compounds disclosed herein are 1 Some or all of the H atoms but 2 It is replaced by an H atom. The synthesis method of deuterium-containing compounds is known in the art. This includes, as merely a non-restrictive example, the following synthesis methods.

[0081] Deuterium-substituted compounds are described by Dean, Dennis C.; Editor. Recent. Advances in the Synthesis and Application ns of Radiolabeled Compounds for Drug Di discovery and development.[In:Curr.,Pharm. Des.,2000;6(10)]2000,110pp, George W.;Var ma,Rajender S.The Synthesis of Radiolabe led Compounds via Organometallic Interme diates, Tetrahedron, 1989, 45(21), 6601-21, Evans, E. Anthony. Synthesis of Radiolabe led compounds,J.Radioanal.Chem.,1981,64( They are synthesized using various methods, such as those described in 1-2) and 9-32.

[0082] Deuterated starting materials are readily available and provide for the synthesis of deuterium-containing compounds. For this purpose, it is subjected to the synthesis methods described herein. Many reagents containing deuterium and The constituent components are commercially available from chemical suppliers such as MilliporeSigma. Yes, they are.

[0083] This disclosure includes salts of the compounds described herein, in particular pharmaceutically acceptable salts. One or more sufficiently acidic functional groups, one or more sufficiently basic functional groups, It consists of one or more sufficiently acidic functional groups and one or more sufficiently basic functional groups. By including both, the compounds of this disclosure form salts (particularly pharmaceutically acceptable salts). Any of the inorganic or organic bases, inorganic acids, organic acids, or combinations thereof It can react with other substances to form salts. Alternatively, it can react with compounds that are inherently charged, for example Compounds containing quaternary nitrogen can form salts with appropriate counterions.

[0084] The compounds and salts described herein are, in some cases, diastereomers, enantiomeric. It may exist as an omer or other stereoisomer. Unless otherwise specified (for example, living (In the table of physical data), the structures disclosed herein are all diastereomers (e.g., , epimer form and enantiomer form, as well as mixtures thereof, explicitly or implicitly It is intended to be included. Separation of stereoisomers is done by chromatography, or It forms diastereomers, which can be recrystallized or chromatographed, or otherwise... This can be carried out by separating by a combination of intents. (This is for reference only for the purposes of this disclosure.) Jean Jacques, Andre Collet, Samue (referenced in the specification) l H. Wilen, “Enantiomers, Racemates and Res. John Wiley And Sons, Inc., 1981) Stereoisomers can also be obtained by stereoselective synthesis.

[0085] In certain embodiments, a compound or a salt of a compound may be a prodrug. For example. In some embodiments, the hydroxyl in the parent compound is an ester or Carboxylic acids presented as carbonates or present in the parent compound are esters and The term “prodrug” is a compound that is converted into the pharmaceutical product of this disclosure under physiological conditions. It is intended to include the compound. One method for creating prodrugs is physiological conditions A molecule containing one or more selected parts that undergo hydrolysis below to expose the desired molecule. In other embodiments, the prodrug is used to target specific cells in a host animal. These are converted by the enzymatic activity of the host animal. For example, esters or carbonates. (For example, esters or carbonates of alcohols or carboxylic acids, and phosphones) Acid esters may be prodrugs of the present disclosure. In some embodiments, The prodrug of min may depend on enzymatic activation. In some embodiments, Amine prodrugs may depend on physiological and chemical conditions for drug release. In several embodiments, the amine prodrug is an amide, carbonate, or N-acyloxy Alkyl derivatives, N-acyloxycarbonyl derivatives, β-aminoketones, (oxodio Xolenyl(methyl) derivatives, N-Mannich bases, imines (e.g., Schiff bases), ena Min, enaminone, azo compound, system capable of lactonization, tetrahydrothia Diazine-2-thione, redox derivatives, or PEG may be selected.

[0086] As described herein, this specification describes the metabolism in vivo that produces compounds. The prodrug forms of the compounds described herein are included in the claims. In some cases, Some of the compounds described herein are producible for other derivatives or active compounds. It could be a rag.

[0087] Prodrugs can sometimes be easier to administer than their parent drugs in certain situations, so It is often useful. Prodrugs are, for example, those that are not bioavailable when administered orally by a parent. In contrast, prodrugs may be available through oral administration. It may help enhance the cellular permeability of compounds. Prodrugs can also be used in pharmaceutical compositions. The solubility of the drug may be improved to exceed that of the parent drug. Prodrugs are site-specific drugs that deliver drugs to specific tissues. Reversible, for use as a denaturing agent to enhance transport or increase intracellular drug retention. It can be designed as a target drug derivative.

[0088] In some embodiments, the design of the prodrug increases the lipophilicity of the pharmaceutical product. In some embodiments, the design of the prodrug increases its effective water solubility. For example, Fedorak et al.,Am.J.Physiol.,269:G210-21 8 (1995), McLoed et al., Gastroenterol, 106: 405-413(1994), Hochhaus et al., Biomed. Chr. om.,6:283-286(1992), J.Larsen and H.Bundg. aard, Int. J. Pharmaceutics, 37, 87 (1987), JL arsen et al.,Int.J.Pharmaceutics,47,103( 1988), Sinkula et al., J. Pharm. Sci., 64:181 -210(1975), T. Higuchi and V. Stella, Pro-dr. ugs as Novel Delivery Systems,Vol.14 of the ACSSymposium Series, and Edward BR Bioreversible Carriers in Drug Desi gn, American Pharmaceutical Association a nd Pergamon Press, 1987 (All such disclosures are incorporated herein by reference) See (to be done). According to another embodiment, the present disclosure produces the previously defined compound A method for achieving this is provided. The compound can be synthesized using prior art. Advantages include, These compounds can, conveniently, be synthesized from readily available starting materials.

[0089] The synthetic chemical modifications and methodologies useful for the synthesis of the compounds described herein are in the Art of the Field. It is publicly known, and for example, R. Larock, Comprehensive O rganic Transformations (1989), TW Greene and PGMWuts,Protective Groups in Orga nic Synthesis, 2d.Ed.(1991), L.Fieser and M.Fieser,Fieser and Fieser's Reagents fo r Organic Synthesis (1994), and L. Paquette, ed.,Encyclopedia of Reagents for Organic This includes the material described in Synthesis (1995). compound

[0090] The following is a consideration of compounds and their salts that may be used in the methods of this disclosure. In embodiments, these compounds and salts are of formulas (I), (II), and (III) It is described in [the document]. In certain embodiments, these compounds and salts are of formula (I), ( This is described in (II-A), (IV), and (III).

[0091] In one phase, equation (I): [ka] A compound represented by or a salt thereof is disclosed herein, in formula (I): X 1 , X 2 , and X 3 These are independently selected from C(R) and N, where X 1 , X 2 , and X 3 At least one of them is N, and X 1 , X2 , and X 3 of Two or fewer of these are N; X 4 is selected from C(R); Each R is independent: Hydrogen, halogen, -NO2, -CN, -N3, -OR 8 , -SR 8 , -N(R 8 )2 , -C(O)R 8 ,-C(O)N(R 8 )2, -N(R 8 )C(O)R 8 , -N(R 8 ) C(O)N(R 8 )2, -OC(O)N(R 8 )2, -N(R 8 )C(O)OR 8 , -C (O)OR 8 ,-OC(O)R 8 ,-S(O)R 8 , and -S(O)2R 8 ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is halogen, -OR 8 , -SR 8 , -N(R 8 )2, -C(O)R 8 , -C( O)N(R 8 )2, -N(R 8 )C(O)R 8 , -C(O)OR 8 ,-OC(O)R 8 , -N(R 8 )C(O)N(R 8 )2, -OC(O)N(R 8 )2, -N(R 8 )C(O) Ure 8 ,-S(O)R 8 -S(O)2R 8 -NO2, =O, =S, =N(R8 ), - CN, C 3~10 One or more independently selected from carbon rings and 3- to 10-membered heterocycles More substituents are substituted as needed, and here this C 3~10 Carbon ring and 3-membered to 10-membered complex rings are R 7 With one or more substituents independently selected from Those which are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 8 , -SR 8 , -N(R 8 )2, -C(O)R 8 ,-C(O)N(R 8 )2, -N (R 8 )C(O)R 8 , -N(R 8 )C(O)N(R 8 )2, -OC(O)N(R 8 )2 , -N(R 8 )C(O)OR 8 , -C(O)OR 8 ,-OC(O)R 8 ,-S(O)R 8 -S(O)2R 8 -NO2, =O-, =S, =N(R 8 ), -CN, C 1~6 Alki Ru, C 2~6 Alkenyl and C 2~6 One or one selected independently of alkinyl It is further substituted with more substituents as needed, where C 1~6 Alkyl, C 2~ 6 alkenyls, and C 2~6 Alkinyl is R 7 One or that is selected independently from More substituents, each as needed. Selected from; R 1 teeth: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O)R 8a ,-C(O)N(R 8a )2, -N(R 8a )C(O)R 8a , -C(O)OR 8a ,- OC(O)R 8a , -N(R 8a )C(O)N(R 8a )2, -OC(O)N(R 8a ) 2, -N(R 8a )C(O)OR 8a ,-S(O)R 8a -S(O)2R 8a , -NO 2, =O, =S, =N(R 8a ), -CN, C 3~10 Carbon rings, and 3- to 10-membered complexes Substituted as needed with one or more substituents independently selected from the ring. Here, this C 3~10 Carbon rings and 3- to 10-membered heterocycles are R 7a Selected independently from One or more substituents of choice, each substituted as necessary; Rabini C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -OR 8a , -SR 8a , -N(R 8a )2, -C(O)R 8a ,-C(O)N(R 8 a )2, -N(R8a )C(O)R 8a , -N(R 8a )C(O)N(R 8a )2, -O C(O)N(R 8a )2, -N(R 8a )C(O)OR 8a , -C(O)OR 8a , -O C(O)R 8a ,-S(O)R 8a -S(O)2R 8a , -NO2, =O-, =S, = N(R 8a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alki Substituted as needed with one or more substituents independently selected from nyl And here C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl is R 7a Each substituent is substituted as needed by one or more substituents selected independently of the original. things that are being done Selected from; or R 1 is R 2 Together with C 3~10 Forming a carbon ring, or a 3- to 10-membered heterocycle, Each of these is a halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O)R 8a ,-C(O)N(R 8a )2, -N(R 8a )C(O)R 8a , -N(R 8a )C( O)N(R 8a )2, -OC(O)N(R 8a )2, -N(R 8a )C(O)OR 8a , -C(O)OR8a ,-OC(O)R 8a ,-S(O)R 8a -S(O)2R 8a ,- NO2, =O-, =S, =N(R) 8a ), -CN, C 1~6 Alkyl, C 2~6 Alkeni Lu, and C 2~6 One or more substituents independently selected from the alkynyl group. And it is replaced as needed, and here C 1~6 Alkyl, C 2~6 Alkenil, and C 2~6 Alkinyl is R 7b One or more substituents selected independently of Each is replaced as needed; R 2 teeth: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is halogen, -OR 8b , -SR 8b , -N(R 8b )2, -C(O)R 8b ,-C(O)N(R 8b )2, -N(R 8b )C(O)R 8b , -C(O)OR 8b ,- OC(O)R 8b , -N(R 8b )C(O)N(R 8b )2, -OC(O)N(R 8b ) 2, -N(R 8b )C(O)OR 8b ,-S(O)R 8b -S(O)2R 8b , -NO 2, =O, =S, =N(R 8b ), -CN, C 3~10 Carbon rings, and 3- to 10-membered complexes Substituted as needed with one or more substituents independently selected from the ring. Here, this C 3~10 Carbon rings and 3- to 10-membered heterocycles are R 7b Selected independently from One or more substituents of choice, each substituted as necessary; Rabini C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -OR 8b , -SR 8b , -N(R 8b )2, -C(O)R 8b ,-C(O)N(R 8 b )2, -N(R 8b )C(O)R 8b , -N(R 8b )C(O)N(R 8b )2, -O C(O)N(R 8b )2, -N(R 8b )C(O)OR 8b , -C(O)OR 8b , -O C(O)R 8b ,-S(O)R 8b -S(O)2R 8b , -NO2, =O-, =S, = N(R 8b ), -CN, -N3, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~ 6. One or more substituents, independently selected from the alkynyl group, can be placed as needed. It has been replaced, and here C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkini Ru is R 7b One or more substituents are independently selected, each as needed. Things that have been replaced Selected from; or R 1 is R 2 Together with C 3~10 Forming a carbon ring, or a 3- to 10-membered heterocycle, Each of these is a halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O)R 8a ,-C(O)N(R 8a )2, -N(R 8a )C(O)R 8a , -N(R 8a )C( O)N(R 8a )2, -OC(O)N(R 8a )2, -N(R 8a )C(O)OR 8a , -C(O)OR 8a ,-OC(O)R 8a ,-S(O)R 8a -S(O)2R 8a ,- NO2, =O-, =S, =N(R) 8a ), -CN, C 1~6 Alkyl, C 2~6 Alkeni Lu, and C 2~6 One or more substituents independently selected from the alkynyl group. And it is replaced as needed, and here C 1~6 Alkyl, C 2~6 Alkenil, and C 2~6 Alkinyl is R 7b One or more substituents selected independently of Each is replaced as needed; R 3 teeth: Hydrogen, halogen, -OR 8c , -SR 8c , -N(R 8c )2, -NO2, and - CN; and R 7c One or more selected independently of one or more C substituted with substituents as needed 1~6 Alkyl Selected from; R 4 teeth: Hydrogen, halogen, -OR 8d , -SR 8d , -N(R 8d )2, -NO2, and - CN; and Halogen, -OR 8d , -SR 8d , -N(R 8d )2, -NO2, and -CN, C 3~10 One or both independently selected from carbon rings and 3-membered to 10-membered heterorings C is substituted as needed with many substituents. 1~6 It is alkyl, and here this C 3~ 10 Carbon rings and 3- to 10-membered heterocycles are R 7d One or that is selected independently from More substituents, each as needed. Selected from; R 4 'teeth: Hydrogen, halogen, -OR 8d , -SR 8d , -N(R 8d )2, -NO2, and - CN; and Halogen, -OR 8d , -SR 8d , -N(R 8d )2, -NO2, and -CN, C 3~10 One or both independently selected from carbon rings and 3-membered to 10-membered heterorings C is substituted as needed with many substituents. 1~6 It is alkyl, and here this C 3~ 10 Carbon rings and 3- to 10-membered heterocycles are R 7d One or that is selected independently from More substituents, each as needed. Selected from; Or R 4 and R 4 'together with C 3~10 Carbon rings, or 3- to 10-membered complexes It forms a ring, and here this C 3~10 A carbon ring, or a 3- to 10-membered heterocycle, is R 7d From Germany It is optionally substituted with one or more substituents selected as appropriate; R 5 teeth: Hydrogen, halogen, -OR 8e , -SR 8e , -N(R 8e )2, -NO2, -CN, C 1~6 Alkyl, C 3~10 Selected from carbon rings and 3-membered to 10-membered heterorings, here This C 1~6 Alkyl, C 3~10 Carbon rings and 3- to 10-membered heterocycles are R 7e From Germany Each substituent is substituted as needed with one or more substituents selected from the set. ; R 6 teeth: Hydrogen, halogen, -OR 8f , -SR 8f , -N(R 8f )2, -NO2, and - CN; and R 7f Replace as needed with one or more substituents selected independently of the original. C 1~6 Alkyl Selected from; Each R 7 , R 7a , R 7b , R 7c , R 7d , R 7e , and R 7f Independently: Halogen, -OR8g , -SR 8g , -N(R 8g )2, -C(O)R 8g , -C( O)N(R 8g )2, -N(R 8g )C(O)R 8g , -N(R 8g )C(O)N(R 8 g )2, -OC(O)N(R 8g )2, -N(R 8g )C(O)OR 8g ,-C(O)O R 8g ,-OC(O)R 8g ,-S(O)R 8g -S(O)2R 8g -NO2, =O ,=S,=N(R 8g ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 8g , -SR 8g , -N(R 8g )2, -C(O)R 8g ,-C(O)N(R 8g )2, -N(R 8g )C(O)R 8g , -N(R 8g )C(O) N(R 8g )2, -OC(O)N(R 8g )2, -N(R 8g )C(O)OR 8g , -C (O)OR 8g ,-OC(O)R 8g ,-S(O)R 8g -S(O)2R 8g , -NO 2, =O, =S, =N(R 8g ), and one or that selected independently from -CN Those that are substituted with more substituents as needed Selected from; Each R 8 , R 8a , R 8b , R 8c , R 8d , R 8e , R 8f , and R 8g Independent : Hydrogen and halogens; and C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl and C 3~10 charcoal These are elementary rings, each of which is a halogen, -CN, -OH, -SH, -NO2, or -NH. 2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 a Lukil)2, -NH(C 1~6 Alkyl), C 3~10 From carbon rings and 3- to 10-membered heterocycles Substituting as needed with one or more substituents that are independently selected. ; and C 3~10 A carbon ring, and a 3-membered to 10-membered heteroring, each of which is a Logen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 a Lukil, -SC 1~6 Alkyl, -SO2-C 1~6 Alkyl, -N(C 1~6 Alki Lu) 2, -NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~ 6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 Haloalkyl Substituting as needed with one or more substituents independently selected from of Selected from.

[0092] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), X 1 , X 2 , and X 3 These are independently selected from C(R) and N, where X 1 , X 2 ,oh Call X 3 At least one of them is N, and X 1 , X 2 , and X 3 2 of N is one or less. In some embodiments, X 1 is N. Several embodiments In X 1 is C(R). In some embodiments, X 2 It is N. In one of the embodiments, X 2 is C(R). In some embodiments, X 3 teeth In some embodiments, X 3 is C(R). In some embodiments X 1 is N, and X 2 is C(R), and X 3 It is C(R). How many In that embodiment, X 1 C(R) and X 2 is N, and X 3 is C(R) In some embodiments, X 1 C(R) and X 2 is C(R), And X 3 In some embodiments, X 1 is N, and X 2 is C(R) And X 3 It is N.

[0093] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R is , or any suitable functional group known to those skilled in the art. In some embodiments, Each R is independently: hydrogen, halogen, -NO2, -CN, -N3, -OR 8 , -SR 8 , -N(R 8 )2, -C(O)R 8 ,-C(O)N(R 8 )2, -N(R 8 )C(O)R 8 , -N(R 8 )C(O)N(R 8 )2, -OC(O)N(R 8 )2, -N(R 8 )C(O )OR 8 , -C(O)OR 8 ,-OC(O)R 8 ,-S(O)R 8 , and -S(O)2 R 8 ;C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, Each of them is halogen, -OR 8 , -SR 8 , -N(R 8 )2, -C(O)R 8 , -C (O)N(R 8 )2, -N(R 8 )C(O)R 8 , -C(O)OR 8 ,-OC(O)R 8 , -N(R 8 )C(O)N(R 8 )2, -OC(O)N(R 8 )2, -N(R 8 )C(O )OR 8 ,-S(O)R 8 -S(O)2R 8-NO2, =O, =S, =N(R 8 ), -CN, C 3~10 One or one independently selected from carbon rings and 3- to 10-membered heterocycles It is substituted with more substituents as needed, and here this C 3~10 Carbohydrate 3-membered to 10-membered complex rings have one or more R 7 Each is replaced as needed. things that are; and C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle, each of these Each is halogen, -OR 8 , -SR 8 , -N(R 8 )2, -C(O)R 8 , -C(O)N (R 8 )2, -N(R 8 )C(O)R 8 , -N(R 8 )C(O)N(R 8 )2, -OC( O)N(R 8 )2, -N(R 8 )C(O)OR 8 , -C(O)OR 8 ,-OC(O)R 8 ,-S(O)R 8 -S(O)2R 8 -NO2, =O-, =S, =N(R 8 ),-CN , C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Selected independently of Alkinnil It is substituted as needed with one or more substituents, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl is one or more R 7 Each is then selected from those that have been replaced as needed.

[0094] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), each R These are independently: hydrogen, halogen, -NO2, -CN, -N3, -OR 8 , -SR 8 , -N( R 8 )2, -C(O)R 8 ,-C(O)N(R 8 )2, -N(R 8 )C(O)R 8 , oyo B-N(R 8 )C(O)N(R 8 )2;C 1~6 Alkyl, C 2~6 Alkenil, and C 2~6 Alkynnyl, where each of these is a halogen, -OR 8 , -SR 8 , -N( R 8 )2, -NO2, =O, =S, =N(R 8 ) one or that is selected independently from Those which are substituted with more substituents as needed; and C 3~10 Carbon ring and Selected from 3-membered to 10-membered heterocycles. In some embodiments, each R is independently a water molecule. Plain, halogen, -CN, -N3, -OR 8 , -SR 8 , -N(R 8 )2, -C(O)R 8 ,-C(O)N(R 8 )2, and -N(R 8 )C(O)R 8 ;C 1~6 Alkyl, C2 ~6 Alkenyl and C 2~6 Alkynnyl, each of which is a halogen, -O R 8 Replaced as needed with one or more substituents independently selected from Those that exist; and C 3~10Selected from carbon rings and 3- to 10-membered heterocycles. In that embodiment, each R is independently: hydrogen, halogen, -CN, -N3, -OR 8 , -SR 8 , -N(R 8 )2;C 1~6 Alkyl and C 2~6 It is alkinyl, and this Each of these requires one or more substituents independently selected from the halogen. Those that are substituted accordingly; and C 3~10 Selected from carbon rings and 3- to 10-membered heterocycles Selected. In some embodiments, each R is independently: -F, -Cl, -Br, -I -CN, -N3, -OR 8 , -SR 8 , -N(R 8 )2,-CF3,methyl, ethyl, Selected from cyclopropyl, -CCMe, phenyl, morpholinyl, and pyrrolidinyl In some embodiments, each R is independently: -F, -Cl, -Br, -I, - CN, -N3, -OR 8 , -SR 8 , -N(R 8 )2,-CF3,methyl, ethyl, cyclamate Selected from ropropyl, -CCMe, phenyl, morpholinyl, and pyrrolidinyl, Here each R 8 These are independently hydrogen, methyl, ethyl, propyl, isopropyl, and cyclopropyl. Pill, isobutyl, -CF3, -CH2CF3, -CH2CHF2, -CH2CF(Me Selected from the group consisting of )2, -CH2CHMe2, and -CH2-phenyl. In this embodiment, each R is independently: -H, -F, Cl, -Br, -I, -CN, -N3 -OH, -OMe, -OEt, -O-propyl, -O-isopropyl, -O-butyl -O-isobutyl, -OCF3, -OCH2CFMe2, -OCH2CHF2, -OCH 2CF3,-OCH2CF(CH3)2,-O-cyclopropyl,-SMe,-SEt, -NH2, -NHMe, -NHEt, -NH-propyl, -NH-cyclopropyl, -N H-butyl, -NH-isobutyl, -NH-cyclobutyl, -NMe2, -NEt2, - NH-phenyl, -Me, -Et, -cyclopropyl, -n-propyl, isopropyl, -Selected from CF3, -CCMe, -morpholinil, and pyrrolidinil. In the embodiment, each R is independently: -H, -F, Cl, -Br, -I, -OH, -M e,-Et,-OCH2CF3,OCH2CHF2,-OMe,-cyclopropyl,- CN, -OEt, -CF3, -O-CF3, -O-cyclopropyl, -n-propyl, i Sopropyl, -OCH2CF(CH3)2, -O-propyl, -O-isopropyl, -O CH2CFMe2, -SMe, -NHMe, -NH2, -NHEt, -CCMe, -NM e2,-NEt2,-N3,-NH-cyclopropyl,-NH-isobutyl,-NH- Selected from phenyl, -morpholinyl, and pyrrolidinyl, in some embodiments, each R is independently: -H, -F, Cl, -Br, -I, -CN, -N3, -OH, -OMe, -OEt, -O-propyl, -O-isopropyl, -OCF3, -OCH2CFMe2, -OCH2CHF2, -OCH2CF3, -OCH2CF(CH3)2, -O-cyclop Ropil, -SMe, -NH2, -NHMe, -NHEt, -NH-cyclopropyl, -N H-isobutyl, -NMe2, -NEt2, -NH-phenyl, -Me, -Et, -Cyc Ropropyl, -n-propyl, isopropyl, -CF3, -CCMe, -morpholinyl, and selected from pyrrolidinyl. In some embodiments, each R is independently: H, -F, Cl, -Br, -I, -CN, -N3, -OH, -OMe, -OEt, -O- Propyl,-O-isopropyl,-OCF3,-OCH2CFMe2,-OCH2CHF 2,-OCH2CF3,-OCH2CF(CH3)2,-O-cyclopropyl,-SMe -NH2, -NHMe, -NHEt, -NEt2, -Me, -Et, -cyclopropyl Selected from -n-propyl, isopropyl, -CF3, and -CCMe.

[0095] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R 1 This can be any suitable functional group known to those skilled in the art. In some embodiments, R 1 ha: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl And each of these is a halogen, -OR 8a , -SR 8a , -N(R 8a )2, - C(O)R 8a ,-C(O)N(R 8a )2, -N(R 8a )C(O)R 8a , -C(O )OR 8a ,-OC(O)R 8a , -N(R 8a )C(O)N(R 8a )2, -OC(O )N(R 8a )2, -N(R 8a )C(O)OR 8a ,-S(O)R 8a -S(O)2 R 8a -NO2, =O, =S, =N(R 8a ), -CN, C3~10 Carbon ring, and 3 With one or more substituents independently selected from a heterocycle of ~10 members as needed It has been replaced, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles are one or more R 7a Each of these is replaced as needed; and C 3~1 0-carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O)R 8a ,-C(O)N(R 8a )2, -N (R 8a )C(O)R 8a , -N(R 8a )C(O)N(R 8a )2, -OC(O)N( R 8a )2, -N(R 8a )C(O)OR 8a , -C(O)OR 8a ,-OC(O)R 8 a ,-S(O)R 8a -S(O)2R 8a -NO2, =O-, =S, =N(R 8a ) ,-CN,C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Independent from Alkinnil It is optionally substituted with one or more substituents selected by the following, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl is one or that More R 7a Each is then selected from those that are replaced as needed; or R 1 is R 2Together with C 3~10 It forms a carbon ring, or a 3- to 10-membered heterocycle, Each of them is halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O)R 8 a ,-C(O)N(R 8a )2, -N(R 8a )C(O)R 8a , -N(R 8a )C(O )N(R 8a )2, -OC(O)N(R 8a )2, -N(R 8a )C(O)OR 8a ,- C(O)OR 8a ,-OC(O)R 8a ,-S(O)R 8a -S(O)2R 8a , -N O2, =O-, =S, =N(R) 8a ), -CN, C 1~6 Alkyl, C 2~6 Alkenil , and C 2~6 With one or more substituents independently selected from the alkynyl group It is replaced as needed, and here C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl is one or more R 7b Each is replaced as needed. In some embodiments, R 1 ha: hydrogen; C 1~6 Alkyl, C 2~6 Alke Nil, and C 2~6 Alkynnyl, where each of these is a halogen, -OR 8a ,- SR 8a , -N(R 8a )2, -C(O)R 8a ,-S(O)R 8a -S(O)2R8 a With one or more substituents independently selected from -NO2 and -CN Those that have been replaced as necessary; and C 3~10 Carbon rings, and 3- to 10-membered complexes A ring, each of which is a halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O)R 8a -NO2, -CN, C 1~6 Alkyl, C 2~6 Alkenil, and C 2~6 With one or more substituents independently selected from the alkynyl as needed. It is replaced here C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 a Lukinil is one or more R 7a Each is replaced as needed. Selected from or R 1 is R 2 Together with C 3~10 A carbon ring, or a three-membered group. ~10-membered heterocycles, each of which is a halogen, -OR 8a , -SR 8a , -N( R 8a )2, -C(O)R 8a ,-S(O)R 8a -S(O)2R 8a , -NO2,- CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Independent of Alkinnil It is optionally replaced with one or more substituents of choice, where C1 ~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl is one or more Many R 7b Each is replaced as needed. In some embodiments, R 1 is hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl Each of these is halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O) R 8a ,-S(O)R 8a -S(O)2R 8a Independent of -NO2 and -CN Substituting as necessary with one or more substituents of selection; and C 3~10 A carbon ring, and a 3-membered to 10-membered heteroring, each of which is a halogen, -C(O)R 8a ,-CN,C 1~6 One or that which is independently selected from alkyl They are selected from those which are substituted as needed with many substituents, or R 1 is R 2 Together with C 3~10 They form a carbon ring, or a 3-membered to 10-membered heterocycle, and each of these Each is halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O)R 8a , -N O2, -CN, and C 1~6 One or more elements independently selected from alkyl groups The substituents are substituted as needed, where C 1~6 Alkyl can be one or more Many R 7b It is replaced as needed. In some embodiments, R 1 teeth, Hydrogen, methyl, -CH2OH, -CH2CH2OH, C(Me)2OH, -CH2OMe is it R 1 is R 2 Together with C 3~10 A carbon ring, or a group of 3 to 10 members. They form heterocycles, each of which is independent of -F, -COMe, -CN, and methyl. It is substituted as needed with one or more substituents selected. In the embodiment, R 1 is hydrogen, methyl, -CH2OH, -CH2CH2OH, C( It is either Me)2OH, -CH2OMe, or R 1 is R 2 Together with: [ka] Each of these forms one or more fluoro, -C(O)Me, -C N and methyl are substituted as needed.

[0096] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R 2 This can be any suitable functional group known to those skilled in the art. In some embodiments, R 2 ha: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl And each of these is a halogen, -OR 8b , -SR 8b , -N(R 8b )2, - C(O)R 8b ,-C(O)N(R 8b )2, -N(R 8b )C(O)R 8b , -C(O )OR 8b ,-OC(O)R 8b, -N(R 8b )C(O)N(R 8b )2, -OC(O )N(R 8b )2, -N(R 8b )C(O)OR 8b ,-S(O)R 8b -S(O)2 R 8b -NO2, =O, =S, =N(R 8b ), -CN, C 3~10 Carbon ring, and 3 With one or more substituents independently selected from a heterocycle of ~10 members as needed It has been replaced, and here this C 3~10 Carbon rings and 3- to 10-membered heterocycles are one or more R 7b Each of these is replaced as needed; and C 3~1 0-carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR 8b , -SR 8b , -N(R 8b )2, -C(O)R 8b ,-C(O)N(R 8b )2, -N (R 8b )C(O)R 8b , -N(R 8b )C(O)N(R 8b )2, -OC(O)N( R 8b )2, -N(R 8b )C(O)OR 8b , -C(O)OR 8b ,-OC(O)R 8 b ,-S(O)R 8b -S(O)2R 8b -NO2, =O-, =S, =N(R 8b ) ,-CN,C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Independent from Alkinnil It is optionally substituted with one or more substituents selected by the following, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl is one or that More R 7b Each is then selected from those that are replaced as needed; or R 1 is R 2 Together with C 3~10 It forms a carbon ring, or a 3- to 10-membered heterocycle, Each of them is halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O)R 8 a ,-C(O)N(R 8a )2, -N(R 8a )C(O)R 8a , -N(R 8a )C(O )N(R 8a )2, -OC(O)N(R 8a )2, -N(R 8a )C(O)OR 8a ,- C(O)OR 8a ,-OC(O)R 8a ,-S(O)R 8a -S(O)2R 8a , -N O2, =O-, =S, =N(R) 8a ), -CN, C 1~6 Alkyl, C 2~6 Alkenil , and C 2~6 With one or more substituents independently selected from the alkynyl group It is replaced as needed, and here C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl is one or more R 7b Each is replaced as needed. Yes, they are.

[0097] In certain embodiments, for a compound or salt of formula (I) or formula (I’), R 2 is: hydrogen, C 1~6 alkyl, and C 2~6 alkenyl, each of which is optionally substituted with one or more substituents independently selected from halo gen, -OR 8b , -SR 8b , -N(R 8b )2, -C(O)R 8b , -S(O)R 8b , -S(O)2R 8b , -NO2, -CN, C 3~10 carbocyclic ring, and one or more substituents independently selected from 3- to 10-membered heterocyclic rings, optionally substituted; wherein this C carbocyclic ring, and 3- to 10-membered heterocyclic ring are each optionally substituted with one or more R 3~10 s; and C carbocyclic ring, 7b and 3- to 10-membered heterocyclic ring, each of which is optionally substituted with one or more substituents independently selected from halogen, -OR 3~10 , -SR , -N(R 8b , -SR 8 b , -N(R 8b )2, -C(O)R 8b , -S(O)R 8b , -S(O)2R 8b , - NO2, -CN, C 1~6 alkyl, C 2~6 alkenyl, and C 2~6 alkynyl, optionally substituted with one or more substituents independently selected therefrom, wherein C alkyl, C 1~6 alkenyl, and C 2~6 alkynyl are each selected from those optionally substituted with one or more R 2~6 s; or is selected from those optionally substituted with one or more R 7b s; or Ruiha R 1 is R 2 Together with C 3~10 Forms a carbon ring or a 3- to 10-membered heterocycle. And each of these is halogen, -OR 8a , -SR 8a , -N(R 8a )2, -C(O )R 8a ,-S(O)R 8a -S(O)2R 8a -NO2, -CN, C 1~6 Alki Ru, C 2~6 Alkenyl and C 2~6 One or one selected independently of alkinyl It is further substituted with more substituents as needed, where C 1~6 Alkyl, C 2~ 6 alkenyls, and C 2~6 Alkinyl is one or more R 7b And each of them It is replaced as needed. In some embodiments, R 2 ha: Hydrogen, C 1~6 a Lukil and C 2~6 Alkenyls, each of which is a halogen, -OR 8b , -SR 8b , -N(R 8b )2, -C(O)R 8b ,-S(O)R 8b -S(O)2R 8b -NO2, -CN, C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. It is substituted as needed with one or more substituents of choice, where this C 3~10 Carbon rings and 3- to 10-membered heterocycles have one or more R 7b Each Those which are replaced as necessary; and C 3~10 Carbon rings, and 3- to 10-membered compound rings. It is an elementary ring, and each of these is a halogen, -OR 8b , -C(O)R 8b , -S(O) 2R 8b , -CN, and C 1~6 One or more that are independently selected from alkyl Many substituents are substituted as needed, and here C 1~6 Alkyl is one or more More R 7b Selected from those that have been replaced as needed; or R 1 is R 2 Together with C 3~10 They form a carbon ring, or a 3-membered to 10-membered heterocycle, and these Each of these is halogen, -C(O)R 8a , -CN, and C 1~6 Independent of alkyl It is optionally replaced with one or more substituents of choice, where C1 ~6 Alkyl is one or more R 7b It is replaced as needed. In one embodiment, R 2 is hydrogen, C 1~6 Alkyl, and C 2~6 Alkenil And each of these is a halogen, -OR 8b , C 3~10 Carbon rings, and 3-membered to 1 Substitution as needed with one or more substituents independently selected from the 0-membered heterocycle. things that are done; and C 3~10 A carbon ring, and a 3-membered to 10-membered heterocycle, Each of these is halogen, -OR 8b , -C(O)R 8b -S(O)2R 8b ,-CN, and C 1~6 Required with one or more substituents independently selected from alkyl. selected from those substituted according to; or R 1 is R 2 together with C 3~10 forms a carbocyclic ring or a 3- to 10-membered heterocyclic ring, each of which is independently selected from halogen, -C (O)R 8a , -CN, and C 1~6 alkyl and is optionally substituted with one or more substituents independently selected therefrom, where C alkyl is optionally substituted with one or 1~6 more R as appropriate. In some embodiments, 7b R is hydrogen, C 2 alkyl, phenyl, or pyridinyl, where this C1 1~2 alkyl is optionally substituted with one or more substituents independently selected from -OH and phenyl, where this phenyl or pyridinyl is optionally substituted with one or more substituents independently selected from -F ~2 , -OH, -OMe, -COMe, -SO2Me, -CN, and methyl. In some embodiments, R is phenyl or pyridinyl, where this phenyl or pyridinyl is optionally substituted with one or more substituents independently selected from -F, -OH, -OMe, -COMe, -SO2Me, -CN, and methyl as appropriate. In some embodiments, R 2 is phenyl or pyridinyl, where this phenyl or pyridinyl is optionally substituted with one or more substituents independently selected from -F, -OH, -OMe, -COMe, -SO2Me, -CN, and methyl as appropriate. In some embodiments, R is R 2 is R 1 together with:

Chemical formula

[0098] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R 3 This can be any suitable functional group known to those skilled in the art. In some embodiments, R 3 H: Hydrogen, halogen, -OR 8c , -SR 8c , -N(R 8c )2, -NO2, and -CN; as well as one or more R 7c And C substituted as needed 1~6 Selected from alkyl groups. In some embodiments, R 3 H: Hydrogen, halogen, -OR 8c , -CN, and C 1~6 Selected from alkyl groups In some embodiments, R 3 is hydrogen and C 1~6 Selected from alkyl groups. In some embodiments, R 3 is hydrogen and C 1~3 Selected from alkyl groups. In some embodiments, R 3 It is hydrogen.

[0099] In some embodiments, [ka] teeth: [ka] Selected from. In some embodiments, [ka] teeth: [ka] Selected from. In some embodiments, [ka] teeth: [ka] Selected from.

[0100] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R 4 This can be any suitable functional group known to those skilled in the art. In some embodiments, And each R 4 These are independently hydrogen, halogen, and -OR 8d , -SR 8d , -N(R 8d )2, -NO2, and -CN; as well as halogens, -OR 8d , -SR 8d , -N(R 8d ) 2, -NO2, and -CN, C 3~10 Independently of carbon rings and 3- to 10-membered heterocycles C is substituted as needed with one or more substituents selected. 1~6 Alki It is a C here 3~10 Carbon rings and 3- to 10-membered heterocycles are one or more More R 7d Each is then selected from those that have been replaced as needed. In the embodiment, each R 4 These are independently hydrogen, halogen, and -OR 8d , and -CN; Also halogen, -OR 8d , and -CN, C 3~10 Carbon rings, and 3- to 10-membered groups Substituted as needed with one or more substituents independently selected from the heterocycle. Ta C 1~6 It is alkyl, and here this C 3~10 Carbon rings, and 3- to 10-membered heterocycles is one or more R 7d Each is then selected from those that have been replaced as needed. In some embodiments, each R 4 These are independently hydrogen, halogen, and -OR 8d , -SR 8d , -N(R 8d )2, -NO2, and -CN; and C 3~10 Carbon ring C1 as needed, substituted with one or more substituents independently selected from ~6 Selected from alkyl groups. In some embodiments, each R 4 Hydrogen, Halogen; and C 3~10 One or more positions independently selected from the carbon ring C substituted as needed by substitution 1~6 Selected from alkyl groups. In some embodiments In this case, each R 4 C1 is independently substituted with hydrogen, -F, and phenyl as needed. Selected from alkyl groups. In some embodiments, each R 4 Independently, hydrogen or It is methyl. In some embodiments, each R 4 is hydrogen. Several embodiments In each R 4 It is methyl.

[0101] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R 4 ’ This can be any suitable functional group known to those skilled in the art. In some embodiments... And each R 4’ These are independently hydrogen, halogen, and -OR 8d , -SR 8d , -N(R 8d ) 2, -NO2, and -CN; as well as halogens, -OR 8d , -SR 8d , -N(R 8 d )2, -NO2, and -CN, C 3~10 From carbon rings and 3- to 10-membered heterocycles C as needed, substituted with one or more substituents selected as appropriate. 1~6 a It is a ru kill, and here this C 3~10 Carbon rings, and 3- to 10-membered heterocycles, are one-to-one is more R 7d Each is then selected from those that have been replaced as needed. In several embodiments, each R 4’ These are independently hydrogen, halogen, and -OR 8d , and - CN; and halogen, -OR 8d , and -CN, C 3~10 Carbon ring, and 3-membered ~ One or more substituents, independently selected from the 10-membered heterocycle, can be placed as needed. Replaced C 1~6 It is alkyl, and here this C 3~10 Carbon rings, and 3- to 10-membered groups A complex algebra is one or more R 7d And each of them is replaced as needed. Selected from. In some embodiments, each R 4’ They are independently hydrogen, halogen, - Ure 8d , -SR 8d , -N(R 8d )2, -NO2, and -CN; and C 3~1 0. Replaced as needed with one or more substituents independently selected from the carbon ring. C 1~6 Selected from alkyl groups. In some embodiments, each R 4’ It is independent hydrogen, halogens; and C 3~10 One or that which is independently selected from the carbon ring C is substituted as needed with many substituents. 1~6 Selected from alkyl groups. In the embodiment, each R 4’ These are independently placed with hydrogen, -F, and phenyl as needed. Selected from the replaced C1 alkyl groups. In some embodiments, each R 4’ It is independent And it is hydrogen or methyl. In some embodiments, each R 4’ It is hydrogen. In some embodiments, each R 4’ R is methyl. 5 This is known to those skilled in the art. It can be any suitable functional group. In some embodiments, R 5 hydrogen, halogen , -OR 8e , -SR 8e , -N(R 8e )2, -NO2, -CN, C 1~6 Alkyl, C 3~10 Selected from carbon rings and 3-membered to 10-membered heterorings, where this C 1~6 Alki Ru, C 3~10 Carbon rings and 3- to 10-membered heterocycles have one or more R 7e Each is replaced as needed.

[0102] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R 5 H: Hydrogen, halogen, -OR 8e , -N(R 8e )2, -CN, C 1~6 Alkyl, C3 ~10Selected from carbon rings and 3-membered to 10-membered heterorings, where this C 1~6 Alkyl, C 3~10 Carbon rings and 3- to 10-membered heterocycles have one or more R 7e Each These are replaced as needed. In some embodiments, R 5 Ha: Hydrogen, Halogens N, -OR 8e , -N(R 8e )2, -CN, C 1~6 Alkyl, and C 3~10 carbon Selected from the ring, here this C 1~6 Alkyl, and C 3~10 A carbon ring is one or More R 7e Each is replaced as needed. In some embodiments R 5 H: Hydrogen, halogen, -OR 8e , -N(R 8e )2, -CN, C 1~3 Alki Lu, and C 3~6 Selected from the carbon ring, here this C 1~6 Alkyl, and C 3~1 A carbon ring has one or more R 7e Each is replaced as needed. In some embodiments, R 5 H: Hydrogen, -Cl, -OH, -OMe, -NHMe, - CN, C 1~2 Selected from alkyl and cyclopropyl, where this C 1~2 Al Kill and cyclopropyl are each substituted as needed with one or more -F. In some embodiments, R 5 These are hydrogen, -Cl, -OH, -OMe, -NHMe, -CN, methyl, ethyl, -CF3, -CHF2, and cyclopropyl They are selected.

[0103] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R 6 This can be any suitable functional group known to those skilled in the art. In some embodiments, R 6 H: Hydrogen, halogen, -OR 8f , -SR 8f , -N(R 8f )2, -NO2, and -CN; as well as one or more R 7f C1 replaced as needed ~6 Selected from alkyl. In some embodiments, R 6 ha: Hydrogen, halogen, -OR 8f ; and one or more R 7f C replaced as needed 1~6 Selected from alkyl. In some embodiments, R 6 ha: Hydrogen, halogen, -O R 8f , and C 1~6 Selected from alkyl. In some embodiments, R 6 teeth , hydrogen and C 1~6 Selected from alkyl. In some embodiments, R 6 teeth, Hydrogen and C 1~3 Selected from alkyl. In some embodiments, R 6 is hydrogen That is the case.

[0104] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R 7 , R 7a , R 7b , R 7c , R 7d , R 7e , and R 7f Each of these is known to those skilled in the art It can be any suitable functional group. In some embodiments, R 7 , R 7a , R 7b , R 7c , R 7d , R 7e , and R 7f Each of these is independent of halogen, -OR 8g , -SR 8g , -N(R 8g )2, -C(O)R 8g ,-C(O)N(R 8g )2, -N (R 8g )C(O)R 8g , -N(R 8g )C(O)N(R 8g )2, -OC(O)N( R 8g )2, -N(R 8g )C(O)OR 8g , -C(O)OR 8g ,-OC(O)R 8 g ,-S(O)R 8g -S(O)2R 8g -NO2, =O, =S, =N(R 8g ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 Alki nil, and each of these is halogen, -OR 8g , -SR 8g , -N(R 8g )2 , -C(O)R 8g ,-C(O)N(R 8g )2, -N(R 8g )C(O)R 8g , -N (R 8g )C(O)N(R 8g )2, -OC(O)N(R 8g )2, -N(R 8g )C( O)OR 8g , -C(O)OR 8g,-OC(O)R 8g ,-S(O)R 8g , -S(O )2R 8g -NO2, =O, =S, =N(R 8g ), and selected independently from -CN Selected from those which are substituted as needed with one or more substituents. .

[0105] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), each R 7 These are independently: halogen, -OR 8g , -N(R 8g )2, -C(O)R 8g , and C 1~3 Selected from alkyl groups. In some embodiments, each R 7 is independent: Hello Gen, -OR 8g , and C 1~3 Selected from alkyl. In some embodiments And each R 7 These are independently selected from halogen, -OH, and -OMe.

[0106] In some embodiments, each R 7a These are independently: halogen, -OR 8g , -N(R 8g )2, -C(O)R 8g , and C 1~3 Selected from alkyl groups. Several implementations In terms of form, each R 7a These are independently: halogen, -OR 8g , and C 1~3 Alkyl Selected from. In some embodiments, each R 7a These are independently: halogen, -OH, Selected from -OMe.

[0107] In some embodiments, each R 7bThese are independently: halogen, -OR 8g , -N(R 8g )2, -C(O)R 8g , and C 1~3 Selected from alkyl groups. Several implementations In terms of form, each R 7b These are independently: halogen, -OR 8g , and C 1~3 Alkyl Selected from. In some embodiments, each R 7b These are independently: halogen, -OH, Selected from -OMe.

[0108] In some embodiments, each R 7c These are independently: halogen, -OR 8g , -N(R 8g )2, -C(O)R 8g , and C 1~3 Selected from alkyl groups. Several implementations In terms of form, each R 7c These are independently: halogen, -OR 8g , and C 1~3 Alkyl Selected from. In some embodiments, each R 7c These are independently: halogen, -OH, Selected from -OMe.

[0109] In some embodiments, each R 7d These are independently: halogen, -OR 8g , -N(R 8g )2, -C(O)R 8g , and C 1~3 Selected from alkyl groups. Several implementations In terms of form, each R 7d These are independently: halogen, -OR 8g , and C 1~3 Alkyl Selected from. In some embodiments, each R 7d These are independently: halogen, -OH, Selected from -OMe.

[0110] In some embodiments, each R 7e These are independently: halogen, -OR 8g , -N(R 8g )2, -C(O)R 8g , and C 1~3 Selected from alkyl groups. Several implementations In terms of form, each R 7e These are independently: halogen, -OR 8g , and C 1~3 Alkyl Selected from. In some embodiments, each R 7e These are independently: halogen, -OH, and -OMe are selected. In some embodiments, each R 7e is fluoro ru.

[0111] In some embodiments, each R 7f These are independently: halogen, -OR 8g , -N(R 8g )2, -C(O)R 8g , and C 1~3 Selected from alkyl groups. Several implementations In terms of form, each R 7f These are independently: halogen, -OR 8g , and C 1~3 Alkyl Selected from. In some embodiments, each R 7f These are independently: halogen, -OH, Selected from -OMe.

[0112] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), R 8 , R 8a , R 8b , R 8c , R 8d , R 8e , R 8f , and R 8gEach of these is for those skilled in the art. It could be any suitable functional group that is more publicly known. In some embodiments, R 8 , R 8a , R 8b , R 8c , R 8d , R 8e , R 8f , and R 8g Each of them independently is hydrogen and halogens; as well as C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl , and C 3~10 A carbon ring, each of which is a halogen, -CN, -OH, -S H, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alki Ru, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 3~10 Carbon ring, 3 With one or more substituents independently selected from a heterocycle of ~10 members as needed Those that have been substituted; and C 3~10 A carbon ring, and a 3-membered to 10-membered heterocycle. Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, = S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -SO2-C 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~ 6 Alkenyl, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 With one or more substituents independently selected from the haloalkyl group, as needed. It is selected from those that have been replaced.

[0113] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), each R 8 These are independently: hydrogen and halogens; as well as C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl and C 3~10 A carbon ring, each of which is a halogen, - CN, -OH, -SH, -NO2, -NH2, C 3~10 Is it a carbon ring, or a 3- to 10-membered heterocycle? Substituting as needed with one or more substituents independently selected from of; as well as C 3~10 A carbon ring, each of which is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl, -SC 1~6 a Lukil, -SO2-C 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon rings, 3-membered to 10-membered heterocycles, and C 1~6 One that is independently selected from haloalkyl groups Or, it is selected from those which are substituted with more substituents as needed. In that embodiment, each R 8 These are independently: hydrogen and halogens; as well as C 1~6 Al Kill, C 2~6 Alkenil, C 2~6 Alkinyl and C 3~10 It is a carbon ring, Each of these is a halogen, -CN, -OH, -NH2, C3~10 Carbon rings, and C 3~ 10 Substitution as needed with one or more substituents independently selected from the carbocyclic ring. These are, respectively, halogen, -CN, -OH, and -OC. 1~6 Alkyl, - SC 1~6 Alkyl, -SO2-C 1~6 Alkyl, -N(C 1~6 Alkyl) 2, - NH(C 1~6 Alkyl), C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 a Substituted as needed with one or more substituents independently selected from lukinyl Selected from those that are available. In some embodiments, each R 8 Hydrogen is independent of hydrogen; and C 1~6 Alkyl, and C 3~10 A carbocyclic ring, each of which is a halogen Hmm, C 3~10 One or more substituents independently selected from the carbon ring are required. Those that are substituted accordingly; and C 3~10 A carbon ring, where each of these is -O Selected from those which are replaced as needed by H. In some embodiments, each R 8 These are hydrogen, methyl, ethyl, propyl, isopropyl, cyclopropyl, and isobutyl. , -CF3, -CH2CF3, -CH2CHF2, -CH2CF(Me)2, -CH2C It is HMe2 or -CH2-phenyl.

[0114] In some embodiments, each R 8a These are independently: hydrogen, halogen, C 1~6 Alki Ru, C 2~6 Alkenyl and C2~6 Selected from alkinyl. Several implementation forms In this state, each R 8a These are independently: hydrogen and C 1~6 Selected from alkyl groups. How many In that embodiment, each R 8a The atoms are independently selected from hydrogen and methyl.

[0115] In some embodiments, each R 8b These are independently: hydrogen, halogen, C 1~6 Alki Ru, C 2~6 Alkenyl and C 2~6 Selected from alkinyl. Several implementation forms In this state, each R 8b These are independently: hydrogen and C 1~6 Selected from alkyl groups. How many In that embodiment, each R 8b The atoms are independently selected from hydrogen and methyl.

[0116] In some embodiments, each R 8c These are independently: hydrogen, halogen, C 1~6 Alki Ru, C 2~6 Alkenyl and C 2~6 Selected from alkinyl. Several implementation forms In this state, each R 8c These are independently: hydrogen and C 1~6 Selected from alkyl groups. How many In that embodiment, each R 8c The atoms are independently selected from hydrogen and methyl.

[0117] In some embodiments, each R 8d These are independently: hydrogen, halogen, C 1~6 Alki Ru, C 2~6 Alkenyl and C 2~6 Selected from alkinyl. Several implementation forms In this state, each R 8d These are independently: hydrogen and C1~6 Selected from alkyl groups. How many In that embodiment, each R 8d The atoms are independently selected from hydrogen and methyl.

[0118] In some embodiments, each R 8e These are independently: hydrogen, halogen, C 1~6 Alki Ru, C 2~6 Alkenyl and C 2~6 Selected from alkinyl. Several implementation forms In this state, each R 8e These are independently: hydrogen and C 1~6 Selected from alkyl groups. How many In that embodiment, each R 8e These are independently selected from hydrogen and methyl. How many In that embodiment, each R e It is hydrogen independently.

[0119] In some embodiments, each R 8f These are independently: hydrogen, halogen, C 1~6 Alki Ru, C 2~6 Alkenyl and C 2~6 Selected from alkinyl. Several implementation forms In this state, each R 8f These are independently: hydrogen and C 1~6 Selected from alkyl groups. How many In that embodiment, each R 8f The atoms are independently selected from hydrogen and methyl.

[0120] In some embodiments, each R 8g These are independently: hydrogen, halogen, C 1~6 Alki Ru, C 2~6 Alkenyl and C 2~6 Selected from alkinyl. Several implementation forms In this state, each R 8g These are independently: hydrogen and C 1~6 Selected from alkyl groups. How many In that embodiment, each R 8g The atoms are independently selected from hydrogen and methyl.

[0121] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), X 2 is N, and X 1 is C(R), and X 3 is C(R). Several embodiments In X 2 is N, and X 1 is C(R), and X 3 It is C(H). In one embodiment, R 1 It is CH3, and R 2 teeth, [ka] In some embodiments, R 1 It is CH3, and R 2 teeth, [ka] In some embodiments, R 1 It is CH2OH, and R 2 teeth, [ka] In some embodiments, R 1 It is CH2OH, and R 2 teeth, [ka] That is the case.

[0122] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), X 2 is N, and X1 is C(CH3), and X 3 is C(R). Several implementations In terms of form, X 2 is N, and X 1 is C(CH3), and X 3 is C(H) In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 teeth C(H) and R 5 is CH3. In some embodiments, X 2 is N Yes, X 1 is C(CH3), and X 3 is C(H), and R 6 H is. In one of the embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H) And R 4 H is H, and R 4 ' is H. In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 3 H is In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C (H) and R 1 is CH3. In some embodiments, X 2 is N ri, X 1 is C(CH3), and X 3 is C(H), and R 1 It is CH2OH In some embodiments, X 2 is N, and X 1 is C(CH3), and X3 is C (H) and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 1 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 1 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 1 It is CH2OH, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 1 It is CH2OH, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 1 It is CH3, and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3is C(H), and R 1 It is CH3, and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 1 It is CH2OH, and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 is C(CH3), and X 3 is C(H), and R 1 It is CH2OH, and R 5 It is CH3, and R 2 teeth, [ka] That is the case.

[0123] In certain embodiments, with respect to a compound or salt of formula (I) or formula (I'), X 2 is N, and X 1 is C(CN), and X 3 is C(R). Several implementation forms In the state, X 2 is N, and X 1 is C(CN), and X 3 is C(H). In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H ) and R 5 is CH3. In some embodiments, X 2 is N, X 1 C(CN) and X 3 is C(H), and R 6 H is several real In the form of construction, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 4 H is H, and R 4 ' is H. In some embodiments, X 2 is N , X 1 C(CN) and X 3 is C(H), and R 3 H is several In the embodiment, X 2 is N, and X 1 C(CN) and X 3 is C(H), And R 1 is CH3. In some embodiments, X 2 is N, and X 1 is C( CN) and X 3 is C(H), and R 1 It is CH2OH. Several implementations In terms of form, X 2 is N, and X 1 C(CN) and X 3 is C(H), and te R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 2teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 1 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 1 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 1 It is CH2OH, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 1 It is CH2OH, and R 2 teeth, [ka] In some embodiments, X 2is N, and X 1 C(CN) and X 3 is C(H), and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 1 It is CH3, and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 1 It is CH3, and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R1 It is CH2OH, and R 5 It is CH3, and R 2 teeth, [ka] In some embodiments, X 2 is N, and X 1 C(CN) and X 3 is C(H), and R 1 It is CH2OH, and R 5 It is CH3, and R 2 teeth, [ka] That is the case.

[0124] In some embodiments, the compound of formula (I) or formula (I') is compound 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 192, 193, 194, 195, 196, 197, 198, 199, 200, 201, 202, 203, 204, 205, 206, 207, 208, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 219, 220, 221, 222, 223, 224, 225, 226, 227, 228, 229, 230, 231, 232, 233, 234, 235, 236, 237, 238, 239、240、241、242、243、244、245、246、247、248、 249、250、251、252、253、254、255、256、257、258、 259、260、261、262、263、264、265、266、267、268、 269、270、271、272、273、274、275、276、277、278、 279、280、281、282、283、284、285、286、287、288、 289、290、291、292、293、294、295、296、297、298、 299、300、301、302、303、304、305、306、307、308、 309、310、311、312、313、314、315、316、317、318、 319、320、321、322、323、324、325、326、327、328、 329、330、331、332、333、334、335、336、337、338、 339、340、341、342、343、344、345、346、347、348、 349、350、351、352、353、354、355、356、357、358、 359、360、361、362、363、364、365、366、367、368、 369、370、371、372、373、374、375、376、377、378、 379、380、381、382、383、384、385、386、387、388、 389、390、391、392、393、394、395、396、397、398、 399、400、401、402、403、404、405、406、407、408、 409、410、411、412、413、414、415、416、417、418、 419, 420, 421, 422, 423, 424, 425, 426, 427, 428, 429, 430, 431, 432, 433, 434, 435, 436, 437, 438, 439, 440, 441, 442, 443, 444, 445, 446, 447, 448, 449, 450, 451, 452, 453, 454, 455, 456, 457, 458, 459, 460, 461, 462, 463, 464, 465, 466, 467, 468, 469, 470, 471, 472, 473, 474, 475, 476, 477, 478, 479, 480, 481, 482, 483, 484, 485, 486, 487, 488, 489, 490, 491, 492, 493, 494, 495, 496, 497, 498, 499, 500, 501, 3001, 3002, 3003, 3004, 3005, 300 6, 3007, 3008, 3009, 3010, 3011, 3012, 3013, 350 2, 3503, 3504, 3505, 3506, 3507, 3508, 3509, 351 0, 3511, 3512, 3513, 3514, 3515, 3516, 3517, 351 Selected from 8 and 3519.

[0125] In some embodiments, the compound of formula (I) or formula (I') is compound 147, 209, 274, 283, 373, 402, 409, 152, 168, 382, ​​391, 401, 149, 150, 177, 357, 370, 377, 380, 385, 439, 305, 355, 139, 170, 174, 185, 225, 256, 288, 492, 227, 242, 332, 374, 172, 381, 406, 407, 187, 196, 202, 230, 359, 420, 3514, 219, 386, 145, 160, 162 、246、392、351、353、366、387、3009、405、433、46 9、3502、376、414、154、167、365、262、384、173、3 508、3515、266、447、281、375、394、285、264、369 、195、181、198、156、183、161、348、138、3509、21 7、363、464、430、158、151、3510、193、204、232、4 19、3516、146、243、3511、192、434、448、456、241 、3010、179、389、349、3504、458、468、248、399、1 63、347、3519、143、350、489、169、3012、308、388 、221、3517、444、364、159、396、189、477、276、30 01、361、255、428、476、411、473、486、460、282、4 00、491、3512、368、395、191、3505、166、424、148 、3518、484、354、208、415、367、445、438、379、18 6、343、260、188、393、273、164、427、250、3507、3 52、418、398、3011、165、197、200、371、459、275、 176、327、441、3503、342、483、472、463、178、284 、239、426、3513、410、478、194、155、224、211、45 5、454、226、190、229、245、238、182、338、453、36 2、344、417、3004、299、345、431、306、488、223、1 57, 212, 432, 278, 304, 254, 153, 413, 171, 358, 2 89, 482, 210, 457, 435, 440, 247, 340, 236, 403, 2 86, 485, 452, 462, 336, 412, 279, 296, 437, 461, o Selected from 425.

[0126] In some embodiments, the compound of formula (I) or formula (I') is compound 147, 209, 274, 283, 373, 402, 409, 152, 168, 382, ​​391, 401, 149, 150, 177, 357, 370, 377, 380, 385, 439, 305, 355, 139, 170, 174, 185, 225, 256, 288, 492, 227, 242, 332, 374, 172, 381, 406, 407, 187, 196, 202, 230, 359, 420, 3514, 219, 386, 145, 160, 162 ,246,392,351,353,366,387,3009,405,433,46 9, 3502, 376, 414, 154, 167, 365, 262, 384, 173, 3 508, 3515, 266, 447, 281, 375, 394, 285, 264, 369 , 195, 181, 198, 156, 183, 161, 348, 138, 3509, 21 7, 363, 464, 430, 158, 151, 3510, 193, 204, 232, 4 19, 3516, 146, 243, 3511, 192, 434, 448, 456, 241 ,3010,179,389,349,3504,458,468,248,399,1 63, 347, 3519, 143, 350, 489, 169, 3012, 308, 388 ,221,3517,444,364,159,396,189,477,276,30 01, 361, 255, 428, 476, 411, 473, 486, 460, 282, 4 00, 491, 3512, 368, 395, 191, 3505, 166, 424, 148 ,3518,484,354,208,415,367,445,438,379,18 6, 343, 260, 188, 393, 273, 164, 427, 250, 3507, 3 52, 418, 398, 3011, 165, 197, 200, 371, 459, 275, 176, 327, 441, 3503, 342, 483, 472, 463, 178, 284 ,239,426,3513,410,478,194,155,224,211,45 5, 454, 226, 190, 229, 245, 238, 182, 338, 453, 36 The numbers are selected from 2, 344, and 417.

[0127] In some embodiments, the compound of formula (I) or formula (I') is compound 147, 209, 274, 283, 373, 402, 409, 152, 168, 382, ​​391, 401, 149, 150, 177, 357, 370, 377, 380, 385, 439, 305, 355, 139, 170, 174, 185, 225, 256, 288, 492, 227, 242, 332, 374, 172, 381, 406, 407, 187, 196, 202, 230, 359, 420, 3514, 219, 386, 145, 160, 162 ,246,392,351,353,366,387,3009,405,433,46 9, 3502, 376, 414, 154, 167, 365, 262, 384, 173, 3 508, 3515, 266, 447, 281, 375, 394, 285, 264, 369 , 195, 181, 198, 156, 183, 161, 348, 138, 3509, 21 7, 363, 464, 430, 158, 151, 3510, 193, 204, 232, 4 19, 3516, 146, 243, 3511, 192, 434, 448, 456, 241 ,3010,179,389,349,3504,458,468,248,399,1 The numbers are selected from 63, 347, 3519, 143, and 350.

[0128] In some embodiments, the compound of formula (I) or formula (I') is compound 147, 209, 274, 283, 373, 402, 409, 152, 168, 382, ​​391, 401, 149, 150, 177, 357, 370, 377, 380, 385, 439, 305, 355, 139, 170, 174, 185, 225, 256, 288, 492, Selected from 227, 242, 332, 374, 172, 381, 406, and 407 ru.

[0129] In some embodiments, the compound of formula (I) or formula (I') is compound 185, 152, 177, 283, 149, 162, 147, 373, 274, 3514, 209 ,355,246,285,139,198,464,402,256,401,332 ,288,382,3515,391,377,3508,173,357,381,3 53, 3502, 492, 385, 407, 374, 406, 393, 439, 3509 , 242, 394, 154, 174, 305, 489, 409, 227, 433, 262 , 150, 146, 380, 476, 202, 151, 365, 230, 351, 170 , 266, 405, 167, 282, 138, 161, 3510, 376, 187, 48 6, 366, 468, 3516, 386, 469, 255, 158, 428, 350, 4 03, 3517, 179, 3009, 243, 160, 420, 225, 181, 477 ,392,3511,264,232,363,195,248,148,156,39 6, 487, 3010, 168, 361, 456, 172, 434, 273, 241, 1 96, 375, 364, 3504, 488, 349, 281, 3503, 3007, 37 9, 472, 193, 159, 183, 348, 143, 473, 217, 219, 44 8, 438, 204, 327, 245, 417, 343, 208, 145, 447, 16 9, 284, 239, 238, 491, 430, 384, 308, 415, 3505, 1 89, 414, 192, 276, 461, 483, 3519, 424, 3001, 399 ,3507,435,176,178,347,445,444,164,427,25 4, 157, 463, 460, 352, 397, 478, 269, 229, 212, 18 2, 367, 388, 188, 475, 404, 368, 390, 190, 221, 39 5, 370, 418, 354, 197, 431, 345, 342, 454, 211, 35 8, 3012, 398, 369, 223, 3513, 155, 482, 258, 426, Select from 199, 471, 432, 250, 277, and 344.

[0130] In some embodiments, the compound of formula (I) or formula (I') is compound 185, 152, 177, 283, 149, 162, 147, 373, 274, 3514, 209 ,355,246,285,139,198,464,402,256,401,332 ,288,382,3515,391,377,3508,173,357,381,3 53, 3502, 492, 385, 407, 374, 406, 393, 439, 3509 , 242, 394, 154, 174, 305, 489, 409, 227, 433, 262 , 150, 146, 380, 476, 202, 151, 365, 230, 351, 170 , 266, 405, 167, 282, 138, 161, 3510, 376, 187, 48 6, 366, 468, 3516, 386, 469, 255, 158, 428, 350, 4 03, 3517, 179, 3009, 243, 160, 420, 225, 181, 477 ,392,3511,264,232,363,195,248,148,156,39 6, 487, 3010, 168, 361, 456, 172, 434, 273, 241, 1 96, 375, 364, 3504, 488, 349, 281, 3503, 3007, 37 9, 472, 193, 159, 183, 348, 143, 473, 217, 219, 44 The numbers are selected from 8, 438, 204, 327, 245, 417, 343, and 208.

[0131] In some embodiments, a compound of formula (I) or formula (I') is selected from the compounds. It will be done.

[0132] In some embodiments, the compound of formula (I) or formula (I') is compound 185, 152, 177, 283, 149, 162, 147, 373, 274, 3514, 209 ,355,246,285,139,198,464,402,256,401,332 ,288,382,3515,391,377,3508,173,357,381,3 53, 3502, 492, 385, 407, 374, 406, 393, 439, 3509 , 242, 394, 154, 174, 305, 489, 409, 227, 433, 262 , 150, 146, 380, 476, 202, 151, 365, 230, and 351 They are selected.

[0133] In some embodiments, the compound of formula (I) or formula (I') is compound 185, Selected from 152 and 177.

[0134] In some embodiments, the compound of formula (I) or formula (I') is compound 152, 283, 373, 209, 355, 382, ​​391, 377, 381, 380, 185, 177, 149, 162, 274, 285, 139, 198, 402, 256, 401, 288, 173, 407, 374, 406, 393, 242, 305, 230, 232, 246, 464, 385, 394, 409, 433, 365, 170, 167, 376, 386, 160, 225, 361, 414, 422, 332, 154, 405, 366, 363, 172, 384, 359, 3514, 187, 447, 360, 147, 351 5, 357, 353, 351, 158, 350, 3508, 227, 392, 204, 3 502, 174, 395, 150, 428, 181, 439, 168, 202, 151, 161, 195, 159, 262, 179, 434, 349, 415, 219, 276, 3509, 208, 169, 3510, 243, 248, 241, 375, 448, 41 7, 444, 196, 352, 403, 420, 354, 387, 419, 200, 48 6, 421, 266, 156, 476, 398, 344, 3516, 430, 389, 4 89, 3511, 226, 492, 367, 473, 399, 281, 423, 282, 347, 404, 411, 379, 400, 224, 371, 3517, 435, 383 ,472,362,206,445,368,364,416,432,284,348 ,370,456,469,396,192,264,236,438,143,157 ,3010,239,327,388,255,217,3512,193,183,4 10, 431, 189, 3503, 245, 273, 201, 3504, 203, 164 , 176, 488, 194, 429, 155, 437, 279, 425, 207, 443 ,343,304,325,372,182,477,254,308,345,178 ,397,441,427,146,418,186,212,221,275,346 , 269, 289, 148, 3012, 278, 440, 138, 238, 475, 15 3, 378, 166, 487, 145, 265, 468, 191, 3001, 229, 1 97, 454, 424, 446, 247, 3505, 306, 233, 455, 3513 ,3004,210,390,483,491,213,286,141,453,35 18, 463, 470, 458, 413, 342, 163, 442, 426, 436, 4 08, 199, 218, 171, 369, 474, 467, 223, 250, 299, 2 34, 211, 214, 280, 335, 188, 261, 338, 318, 484, 1 80, 260, 480, 320, 303, 140, 490, 465, 165, 3011, Selected from 478, 293, and 277.

[0135] In some embodiments, the compound of formula (I) or formula (I') is compound 152, 283、373、209、355、382、391、377、381、380、185、 177、149、162、274、285、139、198、402、256、401、 288、173、407、374、406、393、242、305、230、232、 246、464、385、394、409、433、365、170、167、376、 386、160、225、361、414、422、332、154、405、366、 363、172、384、359、3514、187、447、360、147、351 5、357、353、351、158、350、3508、227、392、204、3 502、174、395、150、428、181、439、168、202、151、 161、195、159、262、179、434、349、415、219、276、 3509、208、169、3510、243、248、241、375、448、41 7、444、196、352、403、420、354、387、419、200、48 6、421、266、156、476、398、344、3516、430、389、4 89、3511、226、492、367、473、399、281、423、282、 347、404、411、379、400、224、371、3517、435、383 、472、362、206、445、368、364、416、432、284、348 、370、456、469、396、192、264、236、438、143、157 、3010、239、327、388、255、217、3512、193、183、4 10、431、189、3503、245、273、201、3504、203、164 , 176, 488, 194, 429, 155, 437, 279, 425, 207, 443 ,343,304,325,372,182,477,254,308,345,178 ,397,441,427,146,418,186,212,221,275,346 , 269, 289, 148, 3012, 278, 440, 138, 238, 475, 15 3, 378, 166, 487, 145, 265, 468, 191, 3001, 229, 1 97, 454, 424, 446, 247, 3505, 306, 233, 455, 3513 ,3004,210,390,483,491,213,286,141,453,35 Select from 18, 463, and 470.

[0136] In some embodiments, the compound of formula (I) or formula (I') is compound 152, 283, 373, 209, 355, 382, ​​391, 377, 381, 380, 185, 177, 149, 162, 274, 285, 139, 198, 402, 256, 401, 288, 173, 407, 374, 406, 393, 242, 305, 230, 232, 246, 464, 385, 394, 409, 433, 365, 170, 167, 376, 386, 160, 225, 361, 414, 422, 332, 154, 405, 366, 363, 172, 384, 359, 3514, 187, 447, 360, 147, 351 5, 357, 353, 351, 158, 350, 3508, 227, 392, 204, 3 502, 174, 395, 150, 428, 181, 439, 168, 202, 151, 161, 195, 159, 262, 179, 434, 349, 415, 219, 276, 3509, 208, 169, 3510, 243, 248, 241, 375, 448, 41 7, 444, 196, 352, 403, 420, 354, 387, 419, 200, 48 6, 421, 266, 156, 476, 398, 344, 3516, 430, 389, 4 89, 3511, 226, 492, 367, 473, 399, 281, 423, 282, 347, 404, 411, 379, 400, 224, 371, 3517, 435, 383 ,472,362,206,445,368,364,416,432,284,348 ,370,456,469,396,192,264,236,438,143,157 ,3010,239,327,388,255,217,3512,193,183,4 Selected from 10, 431, 189, 3503, 245, and 273.

[0137] In some embodiments, the compound of formula (I) or formula (I') is compound 152, 283, 373, 209, 355, 382, ​​391, 377, 381, 380, 185, 177, 149, 162, 274, 285, 139, 198, 402, 256, 401, 288, 173, 407, 374, 406, 393, 242, 305, 230, 232, 246, 464, 385, 394, 409, 433, 365, 170, 167, 376, 386, 160, 225, 361, 414, 422, 332, 154, 405, 366, 363, 172, 384, 359, 3514, 187, 447, 360, 147, 351 5, 357, 353, 351, 158, 350, 3508, 227, 392, 204, 3 Select from 502, 174, 395, 150, 428, and 181.

[0138] In one phase, equation (I-ep): [ka] A compound represented by or a salt thereof is disclosed herein, and in formula (I-ep) : X 1 is selected from C(R) and N; X 2 is selected from C(R) and N; X 3 is selected from C(R) and N; X 4 is selected from C(R) and N; Here X 1 , X 2 , and X 3 At least one of them is N, and X 1 , X 2 , and X 3 Two or fewer of these are N; X 4 is selected from C(R); Each R is independent: Hydrogen; halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), -O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH2, -NH(C 1~ 6 alkyl), and -N(C 1~6 Alkyl)2; Halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), -O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH2, -NH(C 1~6 Al Kill), and -N(C 1~6 One or more alkyl)2 independently selected Many substituents are substituted as needed. 1~6 alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles; and C3~10 Carbon ring and 3 members ~10-membered heterocycle, where each of these is a halogen, -NO2, -CN, -OH, -O (C 1~6 Alkyl), -O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alki Lu), -NH2, -NH(C 1~6 Alkyl), -N(C 1~6 Alkyl)2, C 1~6 Haloalkyl and C 1~6 One or more elements independently selected from alkyl groups Substitutings as needed Selected from; R 1 teeth: hydrogen; Halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), -O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH2, -NH(C 1~6 Al Kill), -N(C 1~6 Alkyl)2, C 3~10 From carbon rings and 3- to 10-membered heterocycles C as needed, substituted with one or more substituents independently selected 1~6 alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), -O(C 1~6 (Haloalkyl) -SH, -S(C 1~6 Alkyl), -NH2, -NH(C 1~6 Alkyl), -N( C 1~6 Alkyl)2, C 1~6 Alkyl, and C 1~6 Selected independently from haloalkyl groups Substituted as needed with one or more substituents of choice Selected from; or R 1 is R 2 Together with C 3~10 Forming a carbon ring, or a 3- to 10-membered heterocycle, Each of these is a halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), - O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH2, -NH( C 1~6 Alkyl), and -N(C 1~6 Alkyl)2, and C 1~6 From alkyl Substituting as needed with one or more substituents independently selected; R 2 teeth: hydrogen; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), -O( C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH2, -NH(C1 ~6 Alkyl), -N(C 1~6 Alkyl)2, C 3~10 Carbon rings and 3- to 10-membered compound rings Substituted as needed with one or more substituents independently selected from the elementary ring. Those who are there; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), -O(C 1~6 (Haloalkyl) -SH, -S(C1~6 Alkyl), -NH2, -NH(C 1~6 Alkyl), -N( C 1~6 Alkyl)2, C 1~6 Alkyl, and C 1~6 Selected independently from haloalkyl groups Substituted as needed with one or more substituents of choice Selected from; or R 1 is R 2 Together with C 3~10 Forming a carbon ring, or a 3- to 10-membered heterocycle, Each of these is a halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), - O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH2, -NH( C 1~6 Alkyl), -N(C 1~6 Alkyl)2, and C 1~6 Independent of alkyl They are substituted as needed with one or more substituents selected; R 3 teeth: hydrogen Selected from; R 4 teeth: Hydrogen, halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), -O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH2, -NH(C 1~ 6 alkyl), -N(C 1~6 Alkyl)2; Halogen, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), -O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH2, -NH(C 1~6 Al Kill), and -N(C 1~6 One or more alkyl)2 independently selected Many substituents are substituted as needed. 1~6 alkyl; C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle, where this C 3~10 Carbon ring And 3-membered to 10-membered heterocycles include halogens, -NO2, -CN, -OH, and -O(C). 1~6 a Lukil), -O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH 2, -NH(C 1~6 Alkyl), and -N(C 1~6 Selected independently from alkyl)2 One or more substituents are substituted as needed. Selected from; R 4 'teeth: Hydrogen, halogens; Halogen, -CN, -OH, -O(C 1~3 Alkyl), -O(C 1~3 Hello Walk Lu), -NH2, -NH(C 1~6 Alkyl), and -N(C 1~6 Alkyl) 2 C as needed, substituted with one or more substituents independently selected 1~3 alkyl; C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle, where this C 3~10 Carbon ring And 3-membered to 10-membered heterocycles include halogens, -CN, -OH, and -O(C) 1~3 Alkyl), -O(C 1~3 Haloalkyl), -NH2, -NH(C) 1~6 Alkyl), and -N( C 1~6 With one or more substituents independently selected from alkyl)2, each Those that are replaced as needed Selected from; Or R 4 and R 4 'together with C 3~10 Carbon rings or 3- to 10-membered heterocycles These form: halogen, -NO2, -CN, -OH, -O(C 1~6 Al Kill), -O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -NH2 , -NH(C 1~6 Alkyl), and -N(C 1~6 Alkyl)2, and C 1~6 a Replaced as needed with one or more substituents independently selected from Lukil We are; R 5 teeth: Hydrogen, halogen, -OH, -O(C) 1~6 Alkyl), -O(C 1~6 Haloalkyl ), -SH, -S(C 1~6 Alkyl), -NH2, -NH(C 1~6 Alkyl), -N (C 1~6 Alkyl)2,-NO2,-CN,C 1~6 Alkyl, C 3~10 Carbon ring, A complex ring is selected from 3-membered to 10-membered rings, where this C 1~6 Alkyl, C 3~10 Carbon ring , and 3-membered to 10-membered heterocycles include halogens, -NO2, -CN, -OH, -O(C) 1~6 Alkyl), -O(C 1~6 Haloalkyl), -SH, -S(C) 1~6 Alkyl), -N H2, -NH(C 1~6 Alkyl), and -N(C 1~6 Selected independently from alkyl)2 Each substituent is substituted as needed by one or more of the selected substituents; R 6 teeth: hydrogen Selected from.

[0139] In one phase, equation (II): [ka] A compound represented by or a salt thereof is disclosed herein, in formula (II): n is 1, 2, 3, or 4; p is 1, 2, or 3; X 11 C(R 17a ) and N are selected; X 12 C(R 17b ) and N are selected; X 13 C(R 17c ) and N are selected; Y 11 C(R 17d ) selected from; Y 12 C(R 17e ) selected from; Each R 11 Independently: Halogen, -NO2, -CN, -N3, -OR 19a , -SR 19a , -N(R 19 a )2, -C(O)R 19a ,-C(O)N(R 19a )2, -N(R 19a )C(O) R 19a , -N(R 19a )C(O)N(R 19a )2, -OC(O)N(R 19a )2 , -N(R 19a )C(O)OR 19a , -C(O)OR 19a ,-OC(O)R19a ,-S(O)R 19a , and -S(O)2R 19a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C(O) R 19a ,-C(O)N(R 19a )2, -N(R 19a )C(O)R 19a , -C(O )OR 19a ,-OC(O)R 19a , -N(R 19a )C(O)N(R 19a )2, - OC(O)N(R 19a )2, -N(R 19a )C(O)OR 19a ,-S(O)R 19 a -S(O)2R 19a -NO2, =O, =S, =N(R 19a ), -N3, -CN , C 3~10 One or both independently selected from carbon rings and 3- to 10-membered heterocycles Many substituents are substituted as needed, and here this C 3~10 Carbon ring and 3 members ~10-membered complex rings are those with one or more R 18a Each is replaced as needed. Those who are there; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C(O)R 19a , -C(O)N (R 19a )2, -N(R19a )C(O)R 19a , -N(R 19a )C(O)N(R 19a )2, -OC(O)N(R 19a )2, -N(R 19a )C(O)OR 19a ,- C(O)OR 19a ,-OC(O)R 19a ,-S(O)R 19a -S(O)2R 19 a -NO2, =O-, =S, =N(R 19a ), -N3, -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 One or that which is selected independently of alkinyl More substituents are substituted as needed, where C 1~6 Alkyl, C 2~6 a Lukenil, and C 2~6 Alkinyl is one or more R 18a Each of them must Those that are replaced as needed Selected from; R 12 teeth: Hydrogen, halogen, -NO2, -N3, -CN, -OR 19b , -SR 19b , -N( R 19b )2, -C(O)R 19b ,-C(O)N(R 19b )2, -N(R 19b )C (O)R 19b , -N(R 19b )C(O)N(R 19b )2, -OC(O)N(R 19 b )2, -N(R 19b )C(O)OR 19b , -C(O)OR 19b ,-OC(O)R 19b,-S(O)R 19b , and -S(O)2R 19b ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is halogen, -OR 19b , -SR 19b , -N(R 19b )2, -C(O) R 19b ,-C(O)N(R 19b )2, -N(R 19b )C(O)R 19b , -C(O )OR 19b ,-OC(O)R 19b , -N(R 19b )C(O)N(R 19b )2, - OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b ,-S(O)R 19 b -S(O)2R 19b -NO2, =O, =S, =N(R 19b ), -N3, -CN , C 3~10 One or both independently selected from carbon rings and 3- to 10-membered heterocycles Many substituents are substituted as needed, and here this C 3~10 Carbon ring and 3 members ~10-membered complex rings are those with one or more R 18b Each is replaced as needed. Those who are there; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19b , -SR 19b , -N(R 19b )2, -C(O)R 19b , -C(O)N (R 19b )2, -N(R 19b )C(O)R 19b, -N(R 19b )C(O)N(R 19b )2, -OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b ,- C(O)OR 19b ,-OC(O)R 19b ,-S(O)R 19b -S(O)2R 19 b -NO2, =O-, =S, =N(R 19b ), -N3, -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 One or that which is selected independently of alkinyl More substituents are substituted as needed, where C 1~6 Alkyl, C 2~6 a Lukenil, and C 2~6 Alkinyl is one or more R 18b Each of them must Those that are replaced as needed Selected from; R 13 teeth: Hydrogen, halogen, -OR 19c , -SR 19c , -N(R 19c )2, -N3, -N O2, and -CN; and Halogen, -OR 19c , -SR 19c , -N(R 19c )2, -N3, -NO2, and one or more substituents selected independently of -CN as needed Replaced C 1~6 alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19c , -SR 19c , -N(R 19c)2, -C(O)R 19c , -C(O)N (R 19c )2, -N(R 19c )C(O)R 19c , -N(R 19c )C(O)N(R 19c )2, -OC(O)N(R 19c )2, -N(R 19c )C(O)OR 19c ,- C(O)OR 19c ,-OC(O)R 19c ,-S(O)R 19c -S(O)2R 19 c , -NO2, -N3, =O-, =S, =N(R 19c ), and selected independently from -CN Substituted as needed with one or more substituents of choice Selected from; R 14 teeth: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2, -N3, -N O2, and -CN; and C 1~6 Alkyl, halogen, -OR 19d , -SR 19d , -N(R 19 d )2, -N3, -NO2, and -CN, one or more selected independently Substituting as necessary with a substituent; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19d , -SR 19d , -N(R 19d )2, -C(O)R 19d , -C(O)N (R 19d )2, -N(R 19d )C(O)R19d , -N(R 19d )C(O)N(R 19d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR 19d ,- C(O)OR 19d ,-OC(O)R 19d ,-S(O)R 19d -S(O)2R 19 d , -NO2, -N3, =O-, =S, =N(R 19d ), and selected independently from -CN Substituted as needed with one or more substituents of choice Selected from; or R 13 is R 14 Together with C 3~10 Forms a carbon ring or a 3- to 10-membered heterocycle. And here is this C 3~10 A carbon ring, or a 3- to 10-membered heterocycle, can consist of one or more carbon rings. Kuno R 18c It is replaced as needed; R 14’ teeth: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2, -N3, -N O2, and -CN; and C 1~6 Alkyl, halogen, -OR 19d , -SR 19d , -N(R 19 d )2, -N3, -NO2, and -CN, one or more selected independently Substituting as necessary with a substituent; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19d , -SR 19d, -N(R 19d )2, -C(O)R 19d , -C(O)N (R 19d )2, -N(R 19d )C(O)R 19d , -N(R 19d )C(O)N(R 19d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR 19d ,- C(O)OR 19d ,-OC(O)R 19d ,-S(O)R 19d -S(O)2R 19 d , -NO2, -N3, =O-, =S, =N(R 19d ), and selected independently from -CN Substituted as needed with one or more substituents of choice Selected from; or R 13 is R 14’ Together with C 3~10 Forms a carbon ring, or a 3- to 10-membered heterocycle. And so, here is this C 3~10 A carbon ring, or a 3- to 10-membered heterocycle, is one or more Many R 18c It is replaced as needed; R 15 teeth: Hydrogen, halogen, -OR 19e , -SR 19e , -N(R 19e )2, -N3, -N O2, and -CN; and One or more R 18d C replaced as needed 1~6 Alkyl Selected from; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed; R 16 teeth: Hydrogen, halogen, -OR 19f , -SR 19f -N(R 19f )2, -N3, -N O2, and -CN; and One or more R 18e C replaced as needed 1~6 Alkyl Selected from; or R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed; Each R 17a Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -N3, -N O2, -CN, -N3; ​​and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of them has one or more R 18fThose that are replaced as needed Selected from; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed; Each R 17b Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -N3, -N O2, -CN, -N3; ​​and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of them has one or more R 18f Those that are replaced as needed Selected from; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed; each R 17c Independently: Hydrogen, halogen, -OR 19g , -SR19g , -N(R 19g )2, -N3, -N O2, -CN, -N3; ​​and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of them has one or more R 18f Those that are replaced as needed Selected from; Each R 17d Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -N3, -N O2, -CN, -N3; ​​and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of them has one or more R 18f Those that are replaced as needed Selected from; Each R 17e Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -N3, -N O2, -CN, -N3; ​​and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of them has one or more R 18f Those that are replaced as needed Selected from; Each R 18a Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h)2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h , -N3, -NO2, =O, =S, =N(R 19h ), and -CN; Furthermore C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h , -N3, -NO2, =O, =S, =N(R 19h ), and - Replaced as needed with one or more substituents selected independently of CN things that Selected from; Each R 18b Independently: Halogen, -OR19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h , -NO2, -N3, =O, =S, =N(R 19h ), and -CN; Furthermore C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h , -NO2, -N3, =O, =S, =N(R 19h ), and - Replaced as needed with one or more substituents selected independently of CN things that Selected from; Each R 18c Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h , -NO2, -N3, =O, =S, =N(R 19h ), and -CN; Furthermore C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R19 h -S(O)2R 19h , -NO2, -N3, =O, =S, =N(R 19h ), and - Replaced as needed with one or more substituents selected independently of CN things that Selected from; Each R 18d Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h , -NO2, -N3, =O, =S, =N(R 19h ), and -CN; Furthermore C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h)2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h , -NO2, -N3, =O, =S, =N(R 19h ), and - Replaced as needed with one or more substituents selected independently of CN things that Selected from; Each R 18e Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h , -NO2, -N3, =O, =S, =N(R 19h ), and -CN; Furthermore C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h , -NO2, -N3, =O, =S, =N(R 19h ), and - Replaced as needed with one or more substituents selected independently of CN things that Selected from; Each R 18f Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h, -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h , -NO2, -N3, =O, =S, =N(R 19h ), and - Replaced as needed with one or more substituents selected independently of CN things that Selected from; Each R 19a Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. Substituted as necessary with one or more substituents of choice; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 a Lukil), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 charcoal Elementary rings, 3-membered to 10-membered heteroalgebras, and C 1~6 One is independently selected from the haloalkyl group. or those which are substituted with more substituents as needed. Selected from; Each R 19b Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. Substituted as necessary with one or more substituents of choice; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 a Lukil), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 charcoal Elementary rings, 3-membered to 10-membered heteroalgebras, and C 1~6 One is independently selected from the haloalkyl group. or those which are substituted with more substituents as needed. Selected from; Each R 19c Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. Substituted as necessary with one or more substituents of choice; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 a Lukil), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 charcoal Elementary rings, 3-membered to 10-membered heteroalgebras, and C 1~6 One is independently selected from the haloalkyl group. or those which are substituted with more substituents as needed. Selected from; Each R 19d Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, -N3, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. Substituted as necessary with one or more substituents of choice; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 a Lukil), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 charcoal Elementary rings, 3-membered to 10-membered heteroalgebras, and C 1~6 One is independently selected from the haloalkyl group. or those which are substituted with more substituents as needed. Selected from; Each R 19e Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - N3, -OC 1~6 Alkyl, -SC1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. Substituted as necessary with one or more substituents of choice; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 a Lukil), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 charcoal Elementary rings, 3-membered to 10-membered heteroalgebras, and C 1~6 One is independently selected from the haloalkyl group. or those which are substituted with more substituents as needed. Selected from; Each R 19f Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, -N3, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. Substituted as necessary with one or more substituents of choice; and C3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 a Lukil), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 charcoal Elementary rings, 3-membered to 10-membered heteroalgebras, and C 1~6 One is independently selected from the haloalkyl group. or those which are substituted with more substituents as needed. Selected from; Each R 19g Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, -N3, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. Substituted as necessary with one or more substituents of choice; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C1~6 a Lukil), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 charcoal Elementary rings, 3-membered to 10-membered heteroalgebras, and C 1~6 One is independently selected from the haloalkyl group. or those which are substituted with more substituents as needed. Selected from; and Each R 19h Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, -N3, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2 , -NH(C 1~6 Alkyl), C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. Substituted as necessary with one or more substituents of choice; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, -N3, =O, =S, -OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 a Lukil), C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 charcoal Elementary rings, 3-membered to 10-membered heteroalgebras, and C 1~6 One is independently selected from the haloalkyl group. or those which are substituted with more substituents as needed. Selected from; Here, at least one R 11 If it is OMe: R 16 teeth: Halogen, -OR 19f , -SR 19f -N(R 19f )2, -N3, -NO2 , and -CN; as well as One or more R 18e C replaced as needed 1~6 Alkyl Selected from; or R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to A 10-membered complex ring is one or more R 18f Is it replaced as needed? or R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to A 10-membered complex ring is one or more R 18f It is replaced as needed; R 15 and R 17a This means they do not form a ring together; R 15 and R 17b This means they do not form a ring together; R 16 and R 17a This means that they do not form a ring together; and R 16 and R 17b They do not form a ring together.

[0140] In one phase, equation (II): [ka] A compound represented by or a salt thereof is disclosed herein, in formula (II): n is 1, 2, 3, or 4; p is 1; X 11 C(R 17a ) and N are selected; X 12 C(R 17b ) and N are selected; X 13 C(R 17c ) and N are selected; Y 11 C(R 17d ) selected from; Y 12 C(R 17e ) selected from; Each R 11 Independently: Halogen, -NO2, -CN, -N3, -OR 19a , -SR 19a , -N(R 19 a )2, -C(O)R 19a ,-C(O)N(R 19a )2, -N(R 19a )C(O) R 19a , -N(R 19a )C(O)N(R 19a )2, -OC(O)N(R 19a )2 , -N(R 19a )C(O)OR 19a , -C(O)OR 19a ,-OC(O)R 19a ,-S(O)R 19a , and -S(O)2R 19a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C(O) R19a ,-C(O)N(R 19a )2, -N(R 19a )C(O)R 19a , -C(O )OR 19a ,-OC(O)R 19a , -N(R 19a )C(O)N(R 19a )2, - OC(O)N(R 19a )2, -N(R 19a )C(O)OR 19a ,-S(O)R 19 a -S(O)2R 19a -NO2, =O, =S, =N(R 19a ), -CN, C 3~ 10 One or more independently selected from carbon rings and 3- to 10-membered heterocycles Substituents are used as needed, and here this C 3~10 Carbon rings and 3- to 10-membered groups A complex algebra is one or more R 18a Each is replaced as needed. ; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C(O)R 19a , -C(O)N (R 19a )2, -N(R 19a )C(O)R 19a , -N(R 19a )C(O)N(R 19a )2, -OC(O)N(R 19a )2, -N(R 19a )C(O)OR 19a ,- C(O)OR 19a ,-OC(O)R 19a ,-S(O)R 19a -S(O)2R 19 a -NO2, =O-, =S, =N(R 19a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 One or more selected independently of alkinyl The substituents are substituted as needed, where C 1~6 Alkyl, C 2~6 Alkenil , and C 2~6 Alkinyl is one or more R 18a Each person as needed things that are being replaced Selected from; R 12 teeth: Hydrogen, halogen, -NO2, -CN, -OR 19b , -SR 19b , -N(R 19b )2, -C(O)R 19b ,-C(O)N(R 19b )2, -N(R 19b )C(O)R 19b , -N(R 19b )C(O)N(R 19b )2, -OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b , -C(O)OR 19b ,-OC(O)R 19b , -S(O)R 19b , and -S(O)2R 19b ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is halogen, -OR 19b , -SR 19b , -N(R 19b )2, -C(O) R 19b ,-C(O)N(R 19b )2, -N(R19b )C(O)R 19b , -C(O )OR 19b ,-OC(O)R 19b , -N(R 19b )C(O)N(R 19b )2, - OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b ,-S(O)R 19 b -S(O)2R 19b -NO2, =O, =S, =N(R 19b ), -CN, C 3~ 10 One or more independently selected from carbon rings and 3- to 10-membered heterocycles Substituents are used as needed, and here this C 3~10 Carbon rings and 3- to 10-membered groups A complex algebra is one or more R 18b Each is replaced as needed. ; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19b , -SR 19b , -N(R 19b )2, -C(O)R 19b , -C(O)N (R 19b )2, -N(R 19b )C(O)R 19b , -N(R 19b )C(O)N(R 19b )2, -OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b ,- C(O)OR 19b ,-OC(O)R 19b ,-S(O)R 19b -S(O)2R 19 b -NO2, =O-, =S, =N(R19b ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 One or more selected independently of alkinyl The substituents are substituted as needed, where C 1~6 Alkyl, C 2~6 Alkenil , and C 2~6 Alkinyl is one or more R 18b Each person as needed things that are being replaced Selected from; R 13 teeth: Hydrogen, halogen, -OR 19c , -SR 19c , -N(R 19c )2, -NO2, o yobi-CN; and Halogen, -OR 19c , -SR 19c , -N(R 19c )2, -NO2, and - Replaced as needed with one or more substituents independently selected from CN. C 1~6 alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19c , -SR 19c , -N(R 19c )2, -C(O)R 19c , -C(O)N (R 19c )2, -N(R 19c )C(O)R 19c , -N(R 19c )C(O)N(R 19c )2, -OC(O)N(R 19c )2, -N(R 19c )C(O)OR 19c ,- C(O)OR 19c ,-OC(O)R 19c,-S(O)R 19c -S(O)2R 19 c -NO2, =O-, =S, =N(R 19c ), and selected independently of -CN Substituted as needed with one or more substituents Selected from; R 14 teeth: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2, -NO2, o yobi-CN; and C 1~6 Alkyl, halogen, -OR 19d , -SR 19d , -N(R 19 d )2, -NO2, and -CN, one or more substitutions selected independently Substitutes as necessary in the base; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19d , -SR 19d , -N(R 19d )2, -C(O)R 19d , -C(O)N (R 19d )2, -N(R 19d )C(O)R 19d , -N(R 19d )C(O)N(R 19d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR 19d ,- C(O)OR 19d ,-OC(O)R 19d ,-S(O)R 19d -S(O)2R 19 d -NO2, =O-, =S, =N(R 19d), and selected independently of -CN Substituted as needed with one or more substituents Selected from; or R 13 is R 14 Together with C 3~10 Forms a carbon ring or a 3- to 10-membered heterocycle. And here is this C 3~10 A carbon ring, or a 3- to 10-membered heterocycle, can consist of one or more carbon rings. Kuno R 18c It is replaced as needed; R 14’ teeth: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2, -NO2, o yobi-CN; and C 1~6 Alkyl, halogen, -OR 19d , -SR 19d , -N(R 19 d )2, -NO2, and -CN, one or more substitutions selected independently Substitutes as necessary in the base; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19d , -SR 19d , -N(R 19d )2, -C(O)R 19d , -C(O)N (R 19d )2, -N(R 19d )C(O)R 19d , -N(R 19d )C(O)N(R 19d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR 19d ,- C(O)OR 19d ,-OC(O)R 19d,-S(O)R 19d -S(O)2R 19 d -NO2, =O-, =S, =N(R 19d ), and selected independently of -CN Substituted as needed with one or more substituents Selected from; or R 13 is R 14’ Together with C 3~10 Forms a carbon ring, or a 3- to 10-membered heterocycle. And so, here is this C 3~10 A carbon ring, or a 3- to 10-membered heterocycle, is one or more Many R 18c It is replaced as needed; R 15 teeth: Hydrogen, halogen, -OR 19e , -SR 19e , -N(R 19e )2, -NO2, o yobi-CN; and One or more R 18d C replaced as needed 1~6 Alkyl Selected from; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed; R 16 teeth: Hydrogen, halogen, -OR 19f , -SR 19f -N(R 19f )2, -NO2, o yobi-CN; and One or more R 18e C replaced as needed 1~6 Alkyl Selected from; or R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed; Each R 17a , R 17b , R 17c , R 17d , and R 17e Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2,- CN, -N3; ​​and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of them has one or more R 18f Those that are replaced as needed Selected from; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed; R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed; each R 18a Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN Substituting as needed with one or more substituents independently selected from of Selected from; Each R 18b Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN Substituting as needed with one or more substituents independently selected from of Selected from; Each R 18c Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN; and C 1~3Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN Substituting as needed with one or more substituents independently selected from of Selected from; Each R 18d Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R19h -NO2, =O, =S, =N(R 19h ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN Substituting as needed with one or more substituents independently selected from of Selected from; Each R 18e Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h, -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN Substituting as needed with one or more substituents independently selected from of Selected from; Each R 18f Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R19h )2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN Substituting as needed with one or more substituents independently selected from of Selected from; Each R 19a Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH (C 1~6 Alkyl), C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle can be independently selected. Substituted as necessary with one or more substituents; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl) , C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon ring, 3 A complex ring with 10 or more members, and C 1~6 One or that independently selected from haloalkyl Those that are substituted with more substituents as needed Selected from; Each R 19b Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH (C 1~6 Alkyl), C 3~10A carbon ring and a 3-membered to 10-membered heterocycle can be independently selected. Substituted as necessary with one or more substituents; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl) , C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon ring, 3 A complex ring with 10 or more members, and C 1~6 One or that independently selected from haloalkyl Those that are substituted with more substituents as needed Selected from; Each R 19c Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH (C 1~6 Alkyl), C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle can be independently selected. Substituted as necessary with one or more substituents; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6Alkyl -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl) , C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon ring, 3 A complex ring with 10 or more members, and C 1~6 One or that independently selected from haloalkyl Those that are substituted with more substituents as needed Selected from; Each R 19d Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH (C 1~6 Alkyl), C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle can be independently selected. Substituted as necessary with one or more substituents; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl) , C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon ring, 3 A complex ring with 10 or more members, and C 1~6 One or that independently selected from haloalkyl Those that are substituted with more substituents as needed Selected from; Each R 19e Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH (C 1~6 Alkyl), C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle can be independently selected. Substituted as necessary with one or more substituents; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl) , C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon ring, 3 A complex ring with 10 or more members, and C 1~6 One or that independently selected from haloalkyl Those that are substituted with more substituents as needed Selected from; Each R 19f Independently: Hydrogen; and C 1~6Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH (C 1~6 Alkyl), C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle can be independently selected. Substituted as necessary with one or more substituents; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl) , C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon ring, 3 A complex ring with 10 or more members, and C 1~6 One or that independently selected from haloalkyl Those that are substituted with more substituents as needed Selected from; Each R 19g Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH (C 1~6 Alkyl), C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle can be independently selected. Substituted as necessary with one or more substituents; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl) , C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon ring, 3 A complex ring with 10 or more members, and C 1~6 One or that independently selected from haloalkyl Those that are substituted with more substituents as needed Selected from; and Each R 19h Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH (C 1~6 Alkyl), C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle can be independently selected. Substituted as necessary with one or more substituents; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl) , C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon ring, 3 A complex ring with 10 or more members, and C 1~6 One or that independently selected from haloalkyl Those that are substituted with more substituents as needed Selected from; Here, at least one R 11 If it is OMe, R 16 It is not hydrogen; R 15 and R 17a This means they do not form a ring together; R 15 and R 17b This means they do not form a ring together; R 16 and R 17a This means that they do not form a ring together; and R 16 and R 17b This means they do not form a ring together; Here R 16 ga: halogen, -OR 19f , -SR 19f -N(R 19f )2, -N O2, and -CN; as well as one or more R 18e Replace as needed C 1~6 If selected from alkyl groups; Y 11 Furthermore, it is selected from N; and Y 12 Furthermore, it is selected from N; Here R 16 R 17aTogether with these, they form a 3-member to 10-member complex ring, and here these 3 A complex ring with ~10 members is a complex ring with one or more R units. 18f Replaced as needed case; Y 11 Furthermore, it is selected from N; and Y 12 Furthermore, it is selected from N; and Here R 16 R 17b Together with these, they form a 3-member to 10-member complex ring, and here these 3 A complex ring with ~10 members is a complex ring with one or more R units. 18f Replaced as needed case; Y 11 Furthermore, it is selected from N; and Y 12 Furthermore, it is selected from N.

[0141] In some embodiments, a compound of formula (II) or formula (II'), variable n and p can be any suitable variable known to those skilled in the art. Several implementations In this state, n is 1, 2, 3, or 4. In some embodiments, n is It is 0, 1, 2, 3, or 4. In some embodiments, n is 1, 2, or It is 3. In some embodiments, n is 1. In some embodiments, n is 2. In some embodiments, n is 3. In some embodiments, In some embodiments, n is 4. In some embodiments, n is 1 or 2. In some embodiments, n is 0 or 1. In some embodiments, n is 0 n is 2. In some embodiments, n is 0 or 3. In some embodiments, n is 0 or 4. In some embodiments, n is 1 or It is 2. In some embodiments, n is 1 or 3. In this, n is 1 or 4. In some embodiments, n is 2 or 3. Yes, in some embodiments, n is 2 or 4. In some embodiments, n is 3 or 4. In some embodiments, n is 0, 1, or 3. In the embodiment, n is 0, 1, or 4. In some embodiments, n is 0 It is 2, or 3. In some embodiments, n is 0, 2, or 4. In some embodiments, n is 0, 3, or 4. And n is 1, 2 or 3. In some embodiments, n is 1, 2 or It is 4. In some embodiments, n is 2, 3, or 4. In the embodiment, n is 0, 1, 2, or 3. In some embodiments, n n is 0, 1, 2, or 4. In some embodiments, n is 1, 2, 3, or In some embodiments, p is 4. In some embodiments, p is 1. In some embodiments, p is 0. In some embodiments, p is 2. In this case, p is 3. In some embodiments, p is 0 or 1. In one embodiment, p is 0 or 2. In some embodiments, p is It is 0 or 3. In some embodiments, p is 1 or 2. In some embodiments, p is 1 or 3. In some embodiments, p is 2. In some embodiments, p is 3. In some embodiments, p is 4. Then, p is 1 or 4. In some embodiments, p is 1, 2, or 3. Yes. In some embodiments, p is 0, 1, or 2. In this state, p is 0, 1, or 3.

[0142] In certain embodiments, with respect to a compound or salt of formula (II) or formula (II'), Each R 11 These are independently halogen, -NO2, -N3, -CN, and -OR 19a , -SR 19 a , -N(R 19a )2, -C(O)R 19a ; Halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C(O)R 19a ,-C(O)N(R 19a )2, -N(R 1 9a )C(O)R 19a , -C(O)OR 19a ,-OC(O)R 19a , -N(R 19 a )C(O)N(R 19a )2, -OC(O)N(R 19a )2, -N(R 19a )C( O)OR 19a ,-S(O)R 19a -S(O)2R 19a -NO2, =O, =S, =N(R 19a ), -CN, C 3~10 Select independently from carbon rings and 3- to 10-membered heterocycles. C is substituted as needed with one or more substituents of choice. 1~6 alkyl; Also halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C(O)R1 9a ,-C(O)N(R 19a )2, -N(R 19a )C(O)R 19a , -N(R 19 a )C(O)N(R 19a )2, -OC(O)N(R 19a )2, -N(R 19a )C( O)OR 19a , -C(O)OR 19a ,-OC(O)R 19a ,-S(O)R 19a , -S(O)2R 19a -NO2, =O-, =S, =N(R 19a ), -CN, -N3, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Selected independently from Alkinnil C is substituted as needed with one or more substituents. 3~10 Selected from the carbocyclic ring Selected. In some embodiments, each R 11 These are independently halogen, -N3, and -C N, -OR 19a , -N(R 19a )2, -C(O)R 19a ;C 1~6 alkyl; oyo bi C 3~10 Selected from the carbon ring. In some embodiments, each R 11 Independent : Halogen, -N3, -CN, -OR 19a , C 1~6 Alkyl, and C 3~10 carbon Selected from the ring. In some embodiments, each R 11 -Cl, -F, -Br, -N3, -CN, -OH, -OMe, methyl, or cyclopropyl. In the embodiment, each R 11These are independently -Cl, -F, -CN, methyl, and cyclo Selected from propyl. In some embodiments, each R 11 These are independent of -F, - Selected from CN and methyl. In some embodiments, each R 11 Independent Selected from -F and -CN. In some embodiments, R 11 is halogen Selected from. In some embodiments, R 11 It is selected from halogens, and te Y 12 It is selected from C(CN), C(H), and C(F). Several implementation forms In the state, R 11 It is selected from halogens, and Y 12 Selected from C(CN) In some embodiments, R 11 It is selected from halogens, and Y 11 teeth Selected from C(H). In some embodiments, R 11 Select from halogen And then X 13 This is selected from N and C(H). In some embodiments , R 11 It is selected from halogen, and X 1 and X 2 It is N. In the application form, R 11 It is selected from halogen, and X 11 is N, C(H), o Selected from C(F). In some embodiments, R 11 Select from halogen Selected, and X 12 This is selected from N, C(H), and C(F).

[0143] In some embodiments, R 11 is selected from F. In some embodiments And, R 11 is selected from F, and Y 12 C(CN), C(H), and C( Selected from F). In some embodiments, R 11 It is selected from F, and Y 12 is selected from C(CN). In some embodiments, R 11 From F Selected, and Y 11 is selected from C(H). In some embodiments, R 11 It is selected from F, and X 13 It is selected from N and C(H). In the embodiment, R 11 It is selected from F, and X 1 and X 2 It is N. In some embodiments, R 11 It is selected from F, and X 11 N, C(H Selected from ), and C(F). In some embodiments, R 11 Select from F Selected, and X 12 This is selected from N, C(H), and C(F).

[0144] In certain embodiments, with respect to a compound or salt of formula (II) or formula (II'), X 11 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H) And Y 12 is C(CN). In some embodiments, X 11 is N , X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), and R 16 This is a C1 alkyl group that is substituted as needed. In some embodiments, X 11 is N, and X 12 is N, and X 13 is C(H) Yes, Y 11 is C(H), and Y 12 is C(CN), and R 16 is -C In some embodiments, X 11 is N, and X 12 is N, and X 1 3 is C(H) and Y 11 is C(H), and Y 12 is C(CN), and te R 15 H is H. In some embodiments, X 11 is N, and X 12 is N ri, X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN) R 14 H is H, and R 14 ' is H. In some embodiments, X 1 1 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H), And Y 12 is C(CN), and R 12 H is. In some embodiments X 11 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H) And Y 12 is C(CN), and R 13 CH3, H, and cyclo Selected from propyl. In some embodiments, X 11 is N, and X 12 is N X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN) And R 13 is selected from CH3. In some embodiments, X 11 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and so do Y 12 is C(CN), and R 13 It is selected from cyclopropyl. In one of the embodiments, X 11 is N, and X 12 is N, and X 13 is C(H) Ri, Y 11 is C(H), and Y 12 is C(CN), and R 13 Is it H? Selected from. In some embodiments, X 11 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), and so do R 11 CH3, cyclopropyl, F, Cl, Br, CF3, CN, N3, OH, and selected from OMe. In some embodiments, X 11 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(C N) and R 11It is selected from CH3, F, Cl, Br, CF3, and CN. In some embodiments, X 11 is N, and X 12 is N, and X 13 is C (H) and Y 11 is C(H), and Y 12 is C(CN), and R 1 1 X is selected from F, Cl, and CN. In some embodiments, X 11 is N Yes, X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), and R 11 It is selected from F and CN. In the form of construction, X 11 is N, and X 12 is N, and X 13 is C(H) and Y 1 1 is C(H), and Y 12 is C(CN), and R 11 Selected from F In some embodiments, X 11 is N, and X 12 is N, and X 13 is C (H) and Y 11 is C(H), and Y 12 is C(CN), and R 1 1 X is selected from CN. In some embodiments, X 11 is N, and X 12 teeth N is X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN ) and n is 1 or 2. In some embodiments, X 11 is N Yes, X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN) and n is 1. In some embodiments, X 11 teeth N is X 12 is N, and X 13 is C(H) and Y 11 is C(H), and te Y 12 is C(CN) and n is 2. In some embodiments, X 1 1 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H), And Y 12 is C(CN), n is 1 or 2, and R 11 , CN Selected from F. In some embodiments, X 11 is N, and X 12 is N ri, X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN) n is 1 or 2, and R 11 It is selected from CN. Several implementation forms In the state, X 11 is N, and X 12 is N, and X 13 is C(H) and Y 11 teeth C(H) and Y 12 is C(CN), n is 1 or 2, and R 11 X is selected from CN. In some embodiments, X 11is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(C N) is such that n is either 1 or 2, and R 11 It is selected from F. In the embodiment, X 11 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), n is 2, and R 11 X is selected from CN and F. In some embodiments, X 11 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C (CN) is such that n is 2, and R 11 It is selected from CN. Several implementations In terms of form, X 11 is N, and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), n is 2, and R 11 teeth, Selected from F. In some embodiments, X 11 is N, and X 12 is C(H) X 13 is N, and Y 11 is C(H), and Y 12 is C(CN) In some embodiments, X 11 is N, and X 12 is C(H) and X 13 teeth N is Y 11 is C(H), and Y 12 It is C(CN). Several implementations In terms of form, X 11 is N, and X 12 is C(H) and X 13 is N, and Y 11 is C(H), and Y 12 is C(CN), and R 16 Place as needed It is a substituted C1 alkyl. In some embodiments, X 11 is N, and X 12 is C(H) and X 13 is N, and Y 11 is C(H), and Y 12 is C(C N) and R 16 is -CH3. In some embodiments, X 11 is N X 12 is C(H) and X 13 is N, and Y 11 is C(H), and Y 12 is C(CN), and R 15 H is H. In some embodiments, X 11 is N, and X 12 is C(H) and X 13 is N, and Y 11 is C(H) , and Y 12 C(CN) and R 14 H is H, and R 14 ' is H. In some embodiments, X 11 is N, and X 12 is C(H) and X 13 is N Yes, Y 11 is C(H), and Y 12 is C(CN), and R 12 is H Yes. In some embodiments, X 11 is N, and X 12 is C(H) and X 1 3 is N, and Y 11 is C(H), and Y 12 is C(CN), and R 1 3 This is selected from CH3, H, and cyclopropyl. In some embodiments , X 11 is N, and X 12 is C(H) and X 13 is N, and Y 11 is C(H) Yes, and Y 12 is C(CN), and R 13 It is selected from CH3. In one of the embodiments, X 11 is N, and X 12 is C(H) and X 13 is N Ri, Y 11 is C(H), and Y 12 is C(CN), and R 13 , Shik Selected from propyl. In some embodiments, X 11 is N, and X 12 teeth C(H) and X 13 is N, and Y 11 is C(H), and Y 12 is C(CN ) and R 13 is selected from H. In some embodiments, X 11 teeth N is X 12 is C(H) and X 13 is N, and Y 11 is C(H), and te Y 12 is C(CN), and R 11 CH3, cyclopropyl, F, Cl, B Selected from r, CF3, CN, N3, OH, and OMe. In some embodiments And, X 11 is N, and X 12 is C(H) and X 13 is N, and Y 11 is C(H ) and Y 12 is C(CN), and R 11 CH3, F, Cl, Br Selected from CF3 and CN. In some embodiments, X 11 is N , X 12 is C(H) and X 13 is N Ri, Y 11 is C(H), and Y 12 is C(CN), and R 11 F, Selected from Cl and CN. In some embodiments, X 11 is N, and X 1 2 is C(H) and X 13 is N, and Y 11 is C(H), and Y 12 is C( CN) and R 11 This is selected from F and CN. In some embodiments And, X 11 is N, and X 12 is C(H) and X 13 is N, and Y 11 is C(H ) and Y 12 is C(CN), and R 11 It is selected from F. In one of the embodiments, X 11 is N, and X 12 is C(H) and X 13 is N Ri, Y 11 is C(H), and Y 12 is C(CN), and R11 , CN Selected from. In some embodiments, X 11 is N, and X 12 is C(H) Yes, X 13 is N, and Y 11 is C(H), and Y 12 is C(CN), And n is 1 or 2. In some embodiments, X 11 is N, and X 1 2 is C(H) and X 13 is N, and Y 11 is C(H), and Y 12 is C( CN) and n is 1. In some embodiments, X 11 is N, X 12 is C(H) and X 13 is N, and Y 11 is C(H), and Y 12 teeth C(CN) and n is 2. In some embodiments, X 11 is N ri, X 12 is C(H) and X 13 is N, and Y 11 is C(H), and Y 1 2 is C(CN), n is 1 or 2, and R 11 Select from CN and F Selected. In some embodiments, X 11 is N, and X 12 is C(H), X 13 is N, and Y 11 is C(H), and Y 12 is C(CN), and n is, It is 1 or 2, and R 11 is selected from CN. In some embodiments , X 11is N, and X 12 is C(H) and X 13 is N, and Y 11 is C(H) Yes, and Y 12 is C(CN), n is 1 or 2, and R 11 C Selected from N. In some embodiments, X 11 is N, and X 12 is C(H) X 13 is N, and Y 11 is C(H), and Y 12 is C(CN) n is either 1 or 2, and R 11 is selected from F. In some embodiments X 11 is N, and X 12 is C(H) and X 13 is N, and Y 11 is C( H) and Y 12 is C(CN), n is 2, and R 11 , CN Selected from F. In some embodiments, X 11 is N, and X 12 is C( H) and X 13 is N, and Y 11 is C(H), and Y 12 is C(CN) Yes, n is 2, and R 11 It was selected from CN. In some embodiments X 11 is N, and X 12 is C(H) and X 13 is N, and Y 11 is C(H) And Y 12 is C(CN), n is 2, and R 11 Select from F It will be done. In some embodiments, X 11C(F) and X 12 is N, and X 13 is C (H) and Y 11 is C(H), and Y 12 is C(CN). In the embodiment, X 11 C(F) and X 12 is N, and X 13 is C(H) Ri, Y 11 is C(H), and Y 12 is C(CN). In some embodiments X 11 C(F) and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), and R 16 Place as needed It is a substituted C1 alkyl. In some embodiments, X 11 C(F) is, X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 teeth C(CN) and R 16 is -CH3. In some embodiments, X 1 1 C(F) and X 12 is N, and X 13 is C(H) and Y 11 is C(H) Yes, and Y 12 is C(CN), and R 15 H is. Several embodiments In X 11 C(F) and X 12 is N, and X 13 is C(H) and Y 1 1 is C(H), and Y12 C(CN) and R 14 H is H, and R 1 4 ' is H. In some embodiments, X 11 C(F) and X 12 is N Yes, X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN) Yes, and R 12 H is H. In some embodiments, X 11 is C(F) , X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), and R 13 It is selected from CH3, H, and cyclopropyl. In some embodiments, X 11 C(F) and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), and R 13 is selected from CH3. In some embodiments, X 11 is C(F) ri, X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 1 2 is C(CN), and R 13 It is selected from cyclopropyl. In the form of construction, X 11 C(F) and X 12 is N, and X 13 is C(H) , Y 11is C(H), and Y 12 is C(CN), and R 13 From H Selected. In some embodiments, X 11 C(F) and X 12 is N , X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN) , and R 11 CH3, cyclopropyl, F, Cl, Br, CF3, CN, N3, O Selected from H and OMe. In some embodiments, X 11 is C(F) ri, X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 1 2 is C(CN), and R 11 These are CH3, F, Cl, Br, CF3, and CN Selected from. In some embodiments, X 11 C(F) and X 12 is N Yes, X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN) Yes, and R 11 This is selected from F, Cl, and CN. In some embodiments, X 11 C(F) and X 12 is N, and X 13 is C(H) and Y 11 is C (H) and Y 12 is C(CN), and R 11 Select from F and CN Selected. In some embodiments, X 11 C(F) and X 12 is N, X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), And R 11 is selected from F. In some embodiments, X 11 is C(F) Yes, X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), and R 11 It was selected from CN. In some embodiments X 11 C(F) and X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), and n is either 1 or 2. In some embodiments, X 11 C(F) and X 12 is N, and X 13 is C (H) and Y 11 is C(H), and Y 12 is C(CN), and n is It is 1. In some embodiments, X 11 C(F) and X 12 is N, X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), And n is 2. 11 C(F) and X 12 teeth N is X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN ) where n is 1 or 2, and R11 It is selected from CN and F. In some embodiments, X 11 C(F) and X 12 is N, and X 13 is C( H) and Y 11 is C(H), and Y 12 is C(CN), and n is 1 and is 2, and R 11 X is selected from CN. In some embodiments, X 1 1 C(F) and X 12 is N, and X 13 is C(H) and Y 11 is C(H) Yes, and Y 12 is C(CN), n is 1 or 2, and R 11 C Selected from N. In some embodiments, X 11 C(F) and X 12 is N X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN) And n is either 1 or 2, and R 11 It is selected from F. Several implementations In terms of form, X 11 C(F) and X 12 is N, and X 13 is C(H), Y 11 is C(H), and Y 12 is C(CN), n is 2, and R 1 1 X is selected from CN and F. In some embodiments, X 11 is C(F) Yes, X 12 is N, and X 13 is C(H) and Y 11 is C(H), and Y 12 is C(CN), n is 2, and R 11 It is selected from CN. How many In that embodiment, X 11 C(F) and X 12 is N, and X 13 is C(H) Y 11 is C(H), and Y 12 is C(CN), n is 2, and so do R 11 It is selected from F.

[0145] In a particular embodiment, with respect to a compound of formula (II) or formula (II'), [ka] teeth, [ka] isn't it.

[0146] In a particular embodiment, with respect to a compound of formula (II) or formula (II'), n is 1 Or it is 2.

[0147] In a particular embodiment, with respect to a compound of formula (II) or formula (II'), n is 1 or 2; and [ka] teeth, [ka] isn't it.

[0148] In one phase, equation (II-A): [ka] A compound represented by or a salt thereof is disclosed herein, and in formula (II-A) : X 11 C(R 17a ) and N are selected; X 12 C(R 17b ) and N are selected; X 13 C(R 17c ) and N are selected; Y 11 C(R 17d ) and N are selected; Y 12 C(R 17e ) and N are selected; Each R 11a , R 11b , R 11c , and R 11d Independently: Hydrogen, halogen, -NO2, -CN, -N3, -OR 19a , -SR 19a , -N( R 19a )2, -C(O)R 19a ,-C(O)N(R 19a )2, -N(R 19a )C (O)R 19a , -N(R 19a )C(O)N(R 19a )2, -OC(O)N(R 19 a )2, -N(R 19a )C(O)OR 19a , -C(O)OR 19a ,-OC(O)R 19a ,-S(O)R 19a , and -S(O)2R 19a ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is halogen, -OR 19a , -SR19a , -N(R 19a )2, -C(O) R 19a ,-C(O)N(R 19a )2, -N(R 19a )C(O)R 19a , -C(O )OR 19a ,-OC(O)R 19a , -N(R 19a )C(O)N(R 19a )2, - OC(O)N(R 19a )2, -N(R 19a )C(O)OR 19a ,-S(O)R 19 a -S(O)2R 19a -NO2, =O, =S, =N(R 19a ), -CN, C 3~ 10 One or more independently selected from carbon rings and 3- to 10-membered heterocycles Substituents are used as needed, and here this C 3~10 Carbon rings and 3- to 10-membered groups The complex algebra is R 18a One or more substituents are selected independently of each of the required ones. Those that are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C(O)R 19a , -C(O)N (R 19a )2, -N(R 19a )C(O)R 19a , -N(R 19a )C(O)N(R 19a )2, -OC(O)N(R 19a )2, -N(R 19a )C(O)OR 19a ,- C(O)OR19a ,-OC(O)R 19a ,-S(O)R 19a -S(O)2R 19 a -NO2, =O-, =S, =N(R 19a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 One or more selected independently of alkinyl The substituents are substituted as needed, where C 1~6 Alkyl, C 2~6 Alkenil , and C 2~6 Alkinyl is R 18a One or more are selected independently from Each substituent is substituted as needed. Selected from; Here R 11a , R 11b , and R 11c When each is hydrogen; R 11d teeth Not hydrogen; Here R 11b If it is -OCH3; R 11c It is not -OMe; R 12 teeth: Hydrogen, halogen, -NO2, -CN, -OR 19b , -SR 19b , -N(R 19b )2, -C(O)R 19b ,-C(O)N(R 19b )2, -N(R 19b )C(O)R 19b , -N(R 19b )C(O)N(R 19b )2, -OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b , -C(O)OR 19b ,-OC(O)R 19b , -S(O)R 19b , and -S(O)2R 19b ; C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is halogen, -OR 19b , -SR 19b , -N(R 19b )2, -C(O) R 19b ,-C(O)N(R 19b )2, -N(R 19b )C(O)R 19b , -C(O )OR 19b ,-OC(O)R 19b , -N(R 19b )C(O)N(R 19b )2, - OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b ,-S(O)R 19 b -S(O)2R 19b -NO2, =O, =S, =N(R 19b ), -CN, C 3~ 10 One or more independently selected from carbon rings and 3- to 10-membered heterocycles Substituents are used as needed, and here this C 3~10 Carbon rings and 3- to 10-membered groups The complex algebra is R 18b One or more substituents are selected independently of each of the required ones. Those that are replaced as needed; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19b , -SR 19b , -N(R 19b )2, -C(O)R 19b , -C(O)N (R 19b )2, -N(R19b )C(O)R 19b , -N(R 19b )C(O)N(R 19b )2, -OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b ,- C(O)OR 19b ,-OC(O)R 19b ,-S(O)R 19b -S(O)2R 19 b -NO2, =O-, =S, =N(R 19b ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 One or more selected independently of alkinyl The substituents are substituted as needed, where C 1~6 Alkyl, C 2~6 Alkenil , and C 2~6 Alkinyl is R 18b One or more are selected independently from Each substituent is substituted as needed. Selected from; R 13 teeth: Hydrogen, halogen, -OR 19c , -SR 19c , -N(R 19c )2, -NO2, o yobi-CN; and Halogen, -OR 19c , -SR 19c , -N(R 19c )2, -NO2, and - Replaced as needed with one or more substituents independently selected from CN. C 1~6 alkyl; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19c , -SR19c , -N(R 19c )2, -C(O)R 19c , -C(O)N (R 19c )2, -N(R 19c )C(O)R 19c , -N(R 19c )C(O)N(R 19c )2, -OC(O)N(R 19c )2, -N(R 19c )C(O)OR 19c ,- C(O)OR 19c ,-OC(O)R 19c ,-S(O)R 19c -S(O)2R 19 c With one or more substituents independently selected from -NO2 and -CN Those that are replaced as needed Selected from; R 14 teeth: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2, -NO2, o yobi-CN; and C 1~6 Alkyl, halogen, -OR 19d , -SR 19d , -N(R 19 d )2, -NO2, and -CN, one or more substitutions selected independently Substitutes as necessary in the base; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19d , -SR 19d , -N(R 19d )2, -C(O)R 19d , -C(O)N (R 19d )2, -N(R 19d )C(O)R 19d , -N(R19d )C(O)N(R 19d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR 19d ,- C(O)OR 19d ,-OC(O)R 19d ,-S(O)R 19d -S(O)2R 19 d -NO2, =O-, =S, =N(R 19d ), and selected independently of -CN Substituted as needed with one or more substituents Selected from; R 14’ teeth: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2, -NO2, o yobi-CN; and C 1~6 Alkyl, halogen, -OR 19d , -SR 19d , -N(R 19 d )2, -NO2, and -CN, one or more substitutions selected independently Substitutes as necessary in the base; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 19d , -SR 19d , -N(R 19d )2, -C(O)R 19d , -C(O)N (R 19d )2, -N(R 19d )C(O)R 19d , -N(R 19d )C(O)N(R 19d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR19d ,- C(O)OR 19d ,-OC(O)R 19d ,-S(O)R 19d -S(O)2R 19 d -NO2, =O-, =S, =N(R 19d ), and selected independently of -CN Substituted as needed with one or more substituents Selected from; or R 14 is R 14’ Together with C 3~10 Forms a carbon ring, or a 3- to 10-membered heterocycle. And so, here is this C 3~10 A carbon ring, or a 3- to 10-membered heterocycle, is R 18c Independent from They are substituted as needed with one or more substituents selected; R 15 teeth: Hydrogen, halogen, -OR 19e , -SR 19e , -N(R 19e )2, -NO2, o yobi-CN; and R 18d One or more substituents, independently selected from the above, can be placed as needed. Replaced C 1~6 Alkyl Selected from; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is R 18f One or more substituents selected independently are required. It is replaced accordingly; R 16 teeth: Hydrogen, halogen, -OR 19f , -SR 19f -N(R 19f )2, -NO2, o yobi-CN; and One or more R 18e C replaced as needed 1~6 Alkyl Selected from; or R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed; Each R 17a , R 17b , R 17c , R 17d , and R 17e Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2,- CN, -N3; ​​and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of them has one or more R 18f Those that are replaced as needed Selected from; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 15 , R 16 , and R 17b These combine to form a bridged complex algebra, and here this has A bridge complex algebra is one or more R 18f It is replaced as needed; Each R 18a , R 18b , R 18c , R 18d , R 18e , and R 18f Independently: Halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O)R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h ) C(O)N(R 19h)2, -OC(O)N(R 19h )2, -N(R 19h )C(O) Ure 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19h , -S (O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN; and C 1~3 Alkyl, C 2~3 Alkenyl and C 2~3 It is alkinyl, and this Each of these is halogen, -OR 19h , -SR 19h , -N(R 19h )2, -C(O) R 19h ,-C(O)N(R 19h )2, -N(R 19h )C(O)R 19h , -N(R 19h )C(O)N(R 19h )2, -OC(O)N(R 19h )2, -N(R 19h ) C(O)OR 19h , -C(O)OR 19h ,-OC(O)R 19h ,-S(O)R 19 h -S(O)2R 19h -NO2, =O, =S, =N(R 19h ), and -CN Substituting as needed with one or more substituents independently selected from of Selected from; Each R 19a , R 19b , R 19c , R 19d , R 19e , R 19f , R 19g , and R 19h Independently: Hydrogen; and C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 It is alkinyl, and this Each of these is a halogen, -CN, -OH, -SH, -NO2, -NH2, =O, =S, - OC 1~6 Alkyl, -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH (C 1~6 Alkyl), C 3~10 A carbon ring and a 3-membered to 10-membered heterocycle can be independently selected. Substituted as necessary with one or more substituents; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen , -CN, -OH, -SH, -NO2, -NH2, =O, =S, -OC 1~6 Alkyl -SC 1~6 Alkyl, -N(C 1~6 Alkyl)2,-NH(C 1~6 Alkyl) , C 1~6 Alkyl, C 2~6 Alkenil, C 2~6 Alkinyl, C 3~10 Carbon ring, 3 A complex ring with 10 or more members, and C 1~6 One or that independently selected from haloalkyl Those that are substituted with more substituents as needed Selected from.

[0149] In certain embodiments, a compound of formula (II), formula (II'), or formula (II-A) Or, regarding salt, X 11 C(R 17a ) and N are selected. Several implementations In terms of form, X 11 C(R 17a ) are selected from. In some embodiments , X 11 is selected from N. In certain embodiments, the compound or salt of formula (II) Regarding X 12 C(R 17b ) and N are selected. In some embodiments And, X 12 C(R 17b ) is selected from. In some embodiments, X 12 is selected from N. In certain embodiments, with respect to the compound or salt of formula (II) , X 13 C(R 17c ) and N are selected. In some embodiments, X 13 C(R 17c ) is selected from. In some embodiments, X 13 Is it N? They are selected.

[0150] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, Y 11 C(R 17d ) are selected from. In some embodiments And, Y 11 C(R 17d ) and N are selected in some embodiments. , Y 11 is selected from N. In certain embodiments, the compound or salt of formula (II) Regarding Y 12 C(R 17e ) is selected from. In some embodiments, Y 12 C(R 17e ) and N are selected.

[0151] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, with respect to salt, each R 11This could be any suitable functional group known to those skilled in the art. In some embodiments, each R 11 These are independently: halogen, -NO2, -N3, - CN, -OR 19a , -SR 19a , -N(R 19a )2, -C(O)R 19a , -C( O)N(R 19a )2, -N(R 19a )C(O)R 19a , -N(R 19a )C(O) N(R 19a )2, -OC(O)N(R 19a )2, -N(R 19a )C(O)OR 19 a , -C(O)OR 19a ,-OC(O)R 19a ,-S(O)R 19a , and -S( O) 2R 19a ;C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinil And each of these is halogen, -OR 19a , -SR 19a , -N(R 19a )2 , -C(O)R 19a ,-C(O)N(R 19a )2, -N(R 19a )C(O)R 19 a , -C(O)OR 19a ,-OC(O)R 19a , -N(R 19a )C(O)N(R 1 9a )2, -OC(O)N(R 19a )2, -N(R 19a )C(O)OR 19a , -S (O)R 19a -S(O)2R 19a-NO2, =O, =S, =N(R 19a ), - CN, C 3~10 One or more independently selected from carbon rings and 3- to 10-membered heterocycles More substituents are substituted as needed, and here this C 3~10 Carbon ring and 3-membered to 10-membered complex rings are those with one or more R 18a Each is replaced as needed. things that are included; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, and these Each is halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C(O)R 1 9a ,-C(O)N(R 19a )2, -N(R 19a )C(O)R 19a , -N(R 19 a )C(O)N(R 19a )2, -OC(O)N(R 19a )2, -N(R 19a )C( O)OR 19a , -C(O)OR 19a ,-OC(O)R 19a ,-S(O)R 19a , -S(O)2R 19a -NO2, =O-, =S, =N(R 19a ), -CN, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 One that is selected independently of alkinyl Or it is substituted with more substituents as needed, where C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl is one or more R 18a Each is then selected from those that have been replaced as needed.

[0152] In a particular embodiment, with respect to a compound or salt of formula (II-A), each R 11a , R 11b , R 11c , and R 11d These are independently hydrogen, halogen, -NO2, -N3, - CN, -OR 19a , -SR 19a , -N(R 19a )2, -C(O)R 19a ;C 1~ It is a 6-alkyl group, which is a halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C(O)R 19a ,-C(O)N(R 19a )2, -N(R 19a )C(O)R 19a , -C(O)OR 19a ,-OC(O)R 19a , -N(R 19a )C(O)N( R 19a )2, -OC(O)N(R 19a )2, -N(R 19a )C(O)OR 19a , -S(O)R 19a -S(O)2R 19a -NO2, =O, =S, =N(R 19a ) ,-CN,C 3~10 One independently selected from carbon rings and 3- to 10-membered heterocycles is substituted with more substituents as needed; and C 3~10 Carbon ring And this is halogen, -OR 19a , -SR 19a , -N(R 19a )2, -C (O)R 19a ,-C(O)N(R 19a)2, -N(R 19a )C(O)R 19a ,- N(R 19a )C(O)N(R 19a )2, -OC(O)N(R 19a )2, -N(R 1 9a )C(O)OR 19a , -C(O)OR 19a ,-OC(O)R 19a , -S(O) R 19a -S(O)2R 19a -NO2, =O-, =S, =N(R 19a ),-CN , -N3, C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Independent from Alkinnil From which one or more substituents are selected and substituted as needed. Selected. In some embodiments, each R 11a , R 11b , R 11c , and R 11d These are independently hydrogen, halogen, -N3, -CN, and -OR 19a , -N(R 19a ) 2, -C(O)R 19a ;C 1~6 alkyl; and C 3~10 Selected from the carbocyclic ring. In some embodiments, each R 11a , R 11b , R 11c , and R 11d is independent -Hydrogen, halogen, -N3, -CN, -OR 19a , C 1~6 Alkyl and C3 ~10 Selected from the carbon ring. In some embodiments, each R 11a , R 11b , R 11c , and R 11d-H, -Cl, -F, -Br, -N3, -CN, -OH, - OMe, methyl, or cyclopropyl. In some embodiments, each R 11 a , R 11b , R 11c , and R 11d These are independently -H, -Cl, -F, -CN, and Me Selected from tyl and cyclopropyl. In some embodiments, each R 11a , R 11b , R 11c , and R 11d These are independently -H, -F, -CN, and methyl Selected from. In some embodiments, each R 11a , R 11b , R 11c , oyo biR 11d These are independently selected from -H, -F, and -CN. Several embodiments In R 11a , R 11b , and R 11c When each is hydrogen; R 11d teeth It is not hydrogen. In some embodiments, R 11b If it is -OCH3; R 11 c is not -OMe. In some embodiments, R 11a , R 11b , and R 1 1c When each is hydrogen; R 11d is not hydrogen; and R 11b -OCH3 If R 11c is not -OMe. In some embodiments, R 11a , R 11b , R 11c , and R 11d Each of these is independently hydrogen, -Cl, -F, -Br, and -C. N, N3, -OH, -OMe, methyl, cyclopropyl, -CH2N(CH3)2, CF 3, and [ka] Selected from; here R 11a , R 11b , and R 11c If each of them is hydrogen; R 11d -Cl, -F, -Br, -CN, N3, -OH, -OMe, methyl, cyclo Selected from propyl, -CH2N(CH3)2, and CF3; where R 11b ga-O If CH3 is the case; R 11c These are independently hydrogen, -Cl, -F, -Br, -CN, N3, Selected from -OH, methyl, cyclopropyl, -CH2N(CH3)2, and CF3 In some embodiments, R 11a , R 11b , R 11c , and R 11d Each Each is independently selected from hydrogen, -F, -CN, and methyl; where R 11a , R 11 b , and R 11c When each is hydrogen; R 11d -F, -CN, and methyl Selected from the options.

[0153] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 12 This can be any suitable functional group known to those skilled in the art. In some embodiments, R 12 H: Hydrogen, halogen, -NO2, -N3, -CN, -OR 19b , -SR 19b , -N(R 19b)2, -C(O)R 19b , -C(O)N (R 19b )2, -N(R 19b )C(O)R 19b , -N(R 19b )C(O)N(R 19b )2, -OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b ,- C(O)OR 19b ,-OC(O)R 19b ,-S(O)R 19b , and -S(O)2 R 19b ;C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl Each of these is halogen, -OR 19b , -SR 19b , -N(R 19b )2, -C (O)R 19b ,-C(O)N(R 19b )2, -N(R 19b )C(O)R 19b ,- C(O)OR 19b ,-OC(O)R 19b , -N(R 19b )C(O)N(R 19b ) 2, -OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b , -S(O) R 19b -S(O)2R 19b -NO2, =O, =S, =N(R 19b ), -CN, C 3~10 One or more independently selected from carbon rings and 3- to 10-membered heterocycles Many substituents are substituted as needed, and here this C 3~10 Carbon ring and 3-membered ~ A 10-membered complex ring is one or more R 18bEach is replaced as needed. things; and C 3~10 A carbon ring and a 3- to 10-membered heterocycle, each of which is , halogen, -OR 19b , -SR 19b , -N(R 19b )2, -C(O)R 19b , -C(O)N(R 19b )2, -N(R 19b )C(O)R 19b , -N(R 19b )C (O)N(R 19b )2, -OC(O)N(R 19b )2, -N(R 19b )C(O)O R 19b , -C(O)OR 19b ,-OC(O)R 19b ,-S(O)R 19b , -S( O) 2R 19b -NO2, =O-, =S, =N(R 19b ), -CN, C 1~6 Alki Ru, C 2~6 Alkenyl and C 2~6 One or one selected independently of alkinyl It is further substituted with more substituents as needed, where C 1~6 Alkyl, C 2~ 6 alkenyls, and C 2~6 Alkinyl is one or more R 18b Each Selected from those in which R is replaced as needed. In some embodiments, R 1 2 H: Hydrogen, halogen, -NO2, -CN, -OR 19b , -SR 19b , -N(R 19 b )2, -C(O)R 19b ; and C 1~6 It is an alkyl group, which is a halogen, -OR 19b , -SR 19b , -N(R 19b )2, -C(O)R 19b , -C(O)N (R 19b )2, -N(R 19b )C(O)R 19b , -C(O)OR 19b ,-OC( O)R 19b , -N(R 19b )C(O)N(R 19b )2, -OC(O)N(R 19b )2, -N(R 19b )C(O)OR 19b ,-S(O)R 19b -S(O)2R 19 b -NO2, =O, =S, =N(R 19b ), -CN, C 3~10 Carbon ring and 3-membered ~ One or more substituents, independently selected from the 10-membered heterocycle, can be placed as needed. Selected from those that have been replaced. In some embodiments, R 12 is hydrogen, halo Gen, -OR 19b , and C 1~6 Selected from alkyl groups. In some embodiments And, R 12 is hydrogen or C 1~6 It is alkyl. In some embodiments, R 12 It is hydrogen.

[0154] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 13 This can be any suitable functional group known to those skilled in the art. In some embodiments, R 13 H: Hydrogen, halogen, -OR 19c , -SR 19c , -N(R 19c)2, -NO2, and -CN; as well as halogens, -OR 19c ,- SR 19c , -N(R 19c )2, -NO2, and one selected independently from -CN C, or more substituents as needed. 1~6 Alkyl; and C3 ~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -OR 1 9c , -SR 19c , -N(R 19c )2, -C(O)R 19c ,-C(O)N(R 19 c )2, -N(R 19c )C(O)R 19c , -N(R 19c )C(O)N(R 19c ) 2, -OC(O)N(R 19c )2, -N(R 19c )C(O)OR 19c , -C(O) Ure 19c ,-OC(O)R 19c ,-S(O)R 19c -S(O)2R 19c , -N O2, =O-, =S, =N(R) 19c ), and one selected independently from -CN It is selected from those which are substituted as needed with more substituents; or R 13 is R 14 Together with C 3~10 They form carbon rings or 3- to 10-membered heterocycles. , here this C 3~10 A carbon ring, or a 3- to 10-membered heterocycle, can be one or more R 18c It is replaced as needed. In some embodiments, R 13 water Element, halogen, -OR19c , -SR 19c , -N(R 19c )2; and C 1~6 a It is Lukil, halogen, -OR 19c , -SR 19c , -N(R 19c )2, -NO 2, and one or more substituents selected independently of -CN as needed Those that have been substituted; and C 3~10 It is a carbon ring, and this is a halogen, -OR 19c , -SR 19c , -N(R 19c )2, -C(O)R 19c ,-C(O)N(R 1 9c )2, -N(R 19c )C(O)R 19c , -N(R 19c )C(O)N(R 19c )2, -OC(O)N(R 19c )2, -N(R 19c )C(O)OR 19c , -C(O )OR 19c ,-OC(O)R 19c ,-S(O)R 19c -S(O)2R 19c ,- NO2, =O-, =S, =N(R) 19c ), and one selected independently from -CN or selected from those which are substituted with more substituents as needed; or is R 13 is R 14 Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 10 A member complex ring is one or more R 18c It is replaced as needed.

[0155] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 13 H: Hydrogen, halogen, -OR 19c , C 1~6 Alkyl, oyo bi C 3~10 Selected from a carbocyclic ring; or R 13 is R 14 Together with the 3 members~ It forms a 10-membered heteroring, where this 3-membered to 10-membered heteroring has one or more R 18c It is replaced as needed. In some embodiments, R 13 ha: hydrogen, -OR 19c , C 1~6 Alkyl and C 3~10 Selected from a carbocyclic ring; or R 13 is R 14 Together with these, they form a 3- to 10-membered heterocycle. In some embodiments... And, R 13 is hydrogen, -OH, -OMe, methyl, cyclopropyl, or R 13 is R 14 Together with it, it forms pyridinyl. In some embodiments, R 13 These are hydrogen, -OH, -OMe, methyl, or cyclopropyl. In the application form, R 13 These are hydrogen, methyl, ethyl, -OH, -OMe, -CF3, -C Selected from (H)F2, -N(H)Me, and cyclopropyl. Several implementations In the state, R 13 R is selected from hydrogen. In some embodiments, 13 teeth, Selected from methyl.

[0156] In certain embodiments, with respect to a compound or salt of formula (II) or formula (II-A) , R 14 This could be any suitable functional group known to those skilled in the art. Several implementations In the state, R 14 These are independently: hydrogen, halogen, -OR 19d , -SR 19d , -N( R 19d )2, -NO2, and -CN; and C 1~6 Alkyl, halogen , -OR 19d , -SR 19d , -N(R 19d ) Independent of 2, -NO2, and -CN Substituting as necessary with one or more substituents selected; Rabini C 3~10 A carbon ring and a 3- to 10-membered heterocycle, each of which is a halogen , -OR 19d , -SR 19d , -N(R 19d )2, -C(O)R 19d , -C(O) N(R 19d )2, -N(R 19d )C(O)R 19d , -N(R 19d )C(O)N( R 19d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR 19d , -C(O)OR 19d ,-OC(O)R 19d ,-S(O)R 19d -S(O)2R 1 9d -NO2, =O-, =S, =N(R 19d ), and selected independently from -CN Selected from those which are substituted as needed with one or more substituents. ; or R 13 is R 14 Together with C 3~10 Carbon rings, or 3- to 10-membered complexes It forms a ring, and here this C 3~10 A carbon ring, or a 3- to 10-membered heterocycle, is one or more More R 18c It is replaced as needed. In some embodiments, R 14 These are independently: hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2, -NO2, and -CN; as well as C 1~6 Alkyl, halogen, -OR 19d , -SR 19d , -N(R 19d ) Selected independently from -NO2 and -CN Substituted as necessary with one or more substituents; and C 3~1 0-carbon rings and 3- to 10-membered heterorings, each of which is a halogen, -OR 19d , -SR 19d , -N(R 19d )2, -C(O)R 19d ,-C(O)N(R 19d ) 2, -N(R 19d )C(O)R 19d , -N(R 19d )C(O)N(R 19d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR 19d , -C(O)OR 19d ,-OC(O)R 19d ,-S(O)R 19d -S(O)2R 19d , -NO2 ,=O-,=S,=N(R 19d ), and one or the other selected independently from -CN From these, a selection is made from those which are substituted with more substituents as needed.

[0157] In certain embodiments, with respect to a compound or salt of formula (II) or formula (II-A) , R14 H: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2; then Bini C 1~6 Alkyl, halogen, -OR 19d , -SR 19d , -N(R 19 d )2, -NO2, and -CN, one or more substitutions selected independently Selected from those that are substituted as needed in the base; or R 13 is R 14 Together C 3~10 It forms a carbon ring, or a 3-membered to 10-membered heterocycle, and here this C 3~1 A 0-carbon ring, or a 3- to 10-membered heterocycle, has one or more R 18c as needed It is replaced by R. In some embodiments, 14 H: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2; and C 1~6 Alkyl, halo Gen, -OR 19d , -SR 19d , -N(R 19d )2, -NO2, and -CN Substituting as needed with one or more substituents that are independently selected. Selected from. In some embodiments, R 14 H: Hydrogen, halogen, -OR 19 d , and C 1~6 Selected from alkyl groups; or R 13 is R 14 Together , C 3~10 It forms a carbon ring or a 3- to 10-membered heterocycle. In some embodiments, R 14H: Hydrogen, halogen, -OR 19d , and C 1~6 Selected from alkyl groups In some embodiments, R 14 is hydrogen, C 1~6 Is it alkyl, or R 13 is R 14 Together with C 3~10 Forms a carbon ring or a 3- to 10-membered heterocycle. In some embodiments, R 14 is hydrogen or C 1~6 It is alkyl. In one embodiment, R 14 is hydrogen, methyl, or R 13 is R 14 and Together, they form pyridinyl. In some embodiments, R 14 is hydrogen or is methyl. In some embodiments, R 14 It is hydrogen, methyl, and fluorine Selected from B. In some embodiments, R 14 It is selected from hydrogen. In one embodiment, R 14 It is selected from hydrogen and methyl. Several implementations In terms of form, R 14 The hydrogen is selected from hydrogen and fluorocarbon. In some embodiments And, R 14 The methyl and fluoro compounds are selected from methyl and fluoro compounds. In some embodiments, R 14 R is selected from hydrogen and cyano. In some embodiments, 14 teeth, Selected from cyano. In some embodiments, R 14 and R 14’ Together with Then, with one or more substituents selected from -F and -CH3 as needed It forms a substituted cyclopropane ring.

[0158] In certain embodiments, with respect to a compound or salt of formula (II) or formula (II-A) , R 14’ This can be any suitable functional group known to those skilled in the art. In terms of form, R 14’ These are independently: hydrogen, halogen, -OR 19d , -SR 19d ,- N(R 19d )2, -NO2, and -CN; and C 1~6 Alkyl, halo Gen, -OR 19d , -SR 19d , -N(R 19d )2, -NO2, and -CN Substituting as needed with one or more substituents that are independently selected. ; and C 3~10 A carbocyclic ring and a 3- to 10-membered heterocyclic ring, each of which is a halo Gen, -OR 19d , -SR 19d , -N(R 19d )2, -C(O)R 19d , -C( O)N(R 19d )2, -N(R 19d )C(O)R 19d , -N(R 19d )C(O) N(R 19d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR 19 d , -C(O)OR 19d ,-OC(O)R 19d ,-S(O)R 19d -S(O)2 R 19d -NO2, =O-, =S, =N(R 19d ), and selected independently of -CN Selected from those which are replaced as needed with one or more substituents. Ruka; or R 13 is R 14’ Together with C 3~10 A carbon ring, or 3-membered to 10-membered groups. It forms a complex ring of members, and here this C 3~10 A carbon ring, or a 3- to 10-membered heterocycle, is a single... or more R 18c It is replaced as needed. In some embodiments R 14’ These are independently: hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19 d )2, -NO2, and -CN; and C 1~6 Alkyl, halogen, -O R 19d , -SR 19d , -N(R 19d )2, -NO2, and -CN are selected independently Substituted as necessary with one or more substituents of choice; and C 3~10 Carbon rings and 3- to 10-membered heterocycles, each of which is a halogen, -O R 19d , -SR 19d , -N(R 19d )2, -C(O)R 19d ,-C(O)N(R 19d )2, -N(R 19d )C(O)R 19d , -N(R 19d )C(O)N(R 19 d )2, -OC(O)N(R 19d )2, -N(R 19d )C(O)OR 19d , -C( O)OR 19d ,-OC(O)R 19d ,-S(O)R 19d -S(O)2R 19d , -NO2, =O-, =S, =N(R 19d), and one selected independently from -CN Alternatively, it can be selected from those that are substituted with more substituents as needed.

[0159] In certain embodiments, with respect to a compound or salt of formula (II) or formula (II-A) , R 14’ H: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2; na Rabini C 1~6 Alkyl, halogen, -OR 19d , -SR 19d , -N(R 1 9d )2, -NO2, and -CN, one or more positions selected independently Selected from those that are substituted as needed in the substitution; or R 13 is R 14’ and Together, C 3~10 It forms a carbon ring, or a 3-membered to 10-membered heterocycle, and here this C3 ~10 A carbon ring, or a 3- to 10-membered heterocycle, has one or more R 18c Needed It is replaced accordingly. In some embodiments, R 14’ ha: Hydrogen, halogen, -OR 19d , -SR 19d , -N(R 19d )2; and C 1~6 Alkyl , halogen, -OR 19d , -SR 19d , -N(R 19d )2, -NO2, and -C Substituting as needed with one or more substituents independently selected from N Selected from those. In some embodiments, R 14’ ha: Hydrogen, halogen, - Ure 19d , and C1~6 Selected from alkyl groups; or R 13 is R 14’ and Together, C 3~10 It forms a carbon ring, or a 3- to 10-membered heterocycle. Several implementations In terms of form, R 14’ H: Hydrogen, halogen, -OR 19d , and C 1~6 Alkyl Selected from. In some embodiments, R 14’ is hydrogen, C 1~6 Alkyl R, or R 13 is R 14’ Together with C 3~10 A carbon ring, or 3-membered to 10-membered groups. It forms a member complex ring. In some embodiments, R 14’ is hydrogen or C 1~6 a In some embodiments, R 14’ Is it hydrogen, methyl, or is R 13 is R 14’ Together with it, it forms pyridinyl. In some embodiments, R 14’ is hydrogen or methyl. In some embodiments, R 14’ teeth, Selected from hydrogen, methyl, and fluoro. In some embodiments, R 14’ R is selected from hydrogen. In some embodiments, 14’ is hydrogen and methyl Selected from. In some embodiments, R 14’ Selected from hydrogen and fluorocarbons. Selected. In some embodiments, R 14’ It is selected from methyl and fluoro In some embodiments, R 14’ The element is selected from hydrogen and cyanoacrylate. In some embodiments, R 14’It is selected from cyanoacrylate. In some embodiments At [ka] teeth: [ka] Selected from. In some embodiments, [ka] teeth: [ka] Selected from. In some embodiments, [ka] teeth: [ka] Selected from. In some embodiments, [ka] teeth: [ka] Selected from. In some embodiments, [ka] teeth: [ka] Selected from. In some embodiments, [ka] teeth: [ka] Selected from.

[0160] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 15 This can be any suitable functional group known to those skilled in the art. In some embodiments, R 15 H: Hydrogen, halogen, -OR 19e , -SR 19e , -N(R 19e )2, -NO2, and -CN; as well as one or more R 18d C replaced as needed 1~6 Selected from alkyl groups; or R 15 teeth R 17a Together with these, they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex ring is one or more R 18f It is replaced as needed; or R 1 5 is R 17b Together with these, they form a 3- to 10-member complex ring, and here this 3- to 10-member complex An elementary ring is one or more R 18f It is replaced as needed. In one embodiment, R 15 ha: hydrogen, -OR 19e , -SR 19e , -N(R 19e )2 , and one or more R 18d C replaced as needed 1~6 Alkyl Selected from; or R 15 is R17a Together with them, they form 3-member to 10-member complex rings. Thus, this 3-membered to 10-membered complex ring can be one or more R 18f as needed It is either replaced by R 15 is R 17b Together with this, 3-member to 10-member complex rings This forms a 3-membered to 10-membered complex ring, where one or more R 18f Needed It is replaced accordingly. In some embodiments, R 15 is: Hydrogen and C 1~6 Selected from alkyl groups; or R 15 is R 17a Together with, 3 to 10 people It forms an elementary ring, where this 3-membered to 10-membered heteroring has one or more R 18f in Substitutions are made as needed; or R 15 is R 17b Together with 3 to 10 It forms a 3-membered to 10-membered complex ring, where this 3-membered to 10-membered complex ring has one or more R 18 f It is replaced as needed. In some embodiments, R 15 is hydrogen, C1 ~6 Is it alkyl; or R 15 is R 17a Together with this, 3-member to 10-member complex rings This forms a 3-membered to 10-membered complex ring, where one or more -OR 19h Ma Taha C 1~3 Substituted with alkyl as needed; or R 15 is R 17b and Together, they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex ring is one more -OR 19h or C 1~3Alkyl is substituted as needed. In some embodiments, R 15 Is it hydrogen; or R 15 is R 17a Together The resulting product is tetrahydroisoquinoli, which is substituted with -OH or methyl as needed. In some embodiments, R 15 is R 17b When combined with something else, it becomes -O It is tetrahydroisoquinoline, substituted with H or methyl as needed. In one embodiment, R 15 It is hydrogen.

[0161] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 16 This can be any suitable functional group known to those skilled in the art. In some embodiments, R 16 H: Hydrogen, halogen, -OR 19f , -SR 19f -N(R 19f )2, -NO2, and -CN; as well as one or more R 18e C replaced as needed 1~6 Selected from alkyl groups; or R 16 teeth R 17a Together with these, they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex ring is one or more R 18f It is replaced as needed; or R 1 6 is R 17b Together with these, they form a 3- to 10-member complex ring, and here this 3- to 10-member complex An elementary ring is one or more R 18f It is replaced as needed. In one embodiment, R16 H: Hydrogen, halogen, -OR 19f , -SR 19f -N(R 19f )2; and one or more R 18e C1 replaced as needed ~6 Selected from alkyl groups; or R 16 is R 17a Together with 3 to 10 It forms a 3-membered to 10-membered complex ring, where this 3-membered to 10-membered complex ring has one or more R 18 f It is replaced as needed; or R 16 is R 17b Together with the 3 members~ It forms a 10-membered heteroring, where this 3-membered to 10-membered heteroring has one or more R 18f It is replaced as needed. In some embodiments, R 16 is hydrogen, -OR 19h C replaced as needed 1~3 It is alkyl; or R 16 is R 1 7a Together with these, they form a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is Halogen, -OR 19h , -SR 19h , -N(R 19h )2, and independent of -CN It is substituted as needed with one or more substituents selected; or is R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 0-membered complex rings include halogens, -OR 19h , -SR 19h , -N(R 19h )2, and - Replaced as needed with one or more substituents independently selected from CN In some embodiments, R 16 is substituted with hydrogen, -OH as needed. C1 alkyl, or R 16 is R 17a Together with one or more Many -F or -CN variants of dihydrobenzofuranyl or dihydro Forms loflopyridinyl. In some embodiments, R 16 It is hydrogen, -OH It is a C1 alkyl group that is substituted as needed, or R 16 is R 17b Together dihydroben, which is substituted as needed with one or more -F or -CN It forms zofuranil or dihydroflopyridinil. In some embodiments, R 16 is hydrogen or methyl. In some embodiments, R 16 It is methyl In some embodiments, R 16 is R 17a Together with: [ka] This forms a -F or -CN which can be replaced as needed with one or more -F or -CN. In some embodiments, R 16 is R 17a Together with: [ka] This forms a -CN which is replaced as needed with one or more -CNs. In some embodiments, R 16 is R 17a Together with: [ka] This forms a -F which is replaced as needed with one or more -F. In one embodiment, R 16 is R 17b Together with: [ka] This forms a -F or -CN which can be replaced as needed with one or more -F or -CN. In some embodiments, R 16 is R 17b Together with: [ka] This forms a -CN which is replaced as needed with one or more -CNs. In some embodiments, R 16 is R 17b Together with: [ka] This forms a -F which is replaced as needed with one or more -F. In one embodiment, R 16 This is a C1 alkyl group substituted with hydrogen and -OH as needed. In some embodiments, R 16 is hydrogen, methyl, or CH2OH Yes. In some embodiments, R 16 It is methyl or CH2OH. In one embodiment, R 16 It is methyl.

[0162] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 16 and R 17a Together with that, [ka] They form 3-membered to 10-membered complex rings selected from these.

[0163] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or regarding salt, [ka] teeth, [ka] Selected from.

[0164] In some embodiments, R 16 and R 17a Together with that, [ka] They form 3-membered to 10-membered complex rings selected from these.

[0165] In some embodiments, R 16 and R 17b Together with that, [ka] They form 3-membered to 10-membered complex rings selected from these.

[0166] In some embodiments, R 16 and R 17b Together with that, [ka] They form 3-membered to 10-membered complex rings selected from these.

[0167] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, with respect to salt, each R 17a , R 17b , R 17c , R 17d , and R 17e This is It may be any suitable functional group known to the manufacturer. In some embodiments, each R 17a , R 17b , R 17c , R 17d , and R 17e These are independently: hydrogen, halogen , -OR 19g , -SR 19g , -N(R 19g )2, -NO2, and -CN; and one or more R 18f C replaced as needed 1~6 Selected from alkyl groups Selected. Or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, Thus, these 3-member to 10-member complex rings can be one or more R 18f Replace as needed Is it being done; or R 16 is R 17a Together with them, they form 3-member to 10-membered complex rings. Here, this 3-membered to 10-membered complex ring has one or more R 18f as needed Substituted or R 15 is R 17b Together with them, they form 3-member to 10-member complex rings. Thus, this 3-membered to 10-membered complex ring can be one or more R 18f as needed It is either replaced by R 16 is R 17b Together with this, 3-member to 10-member complex rings This forms a 3-membered to 10-membered complex ring, where one or more R 18fNeeded It is replaced accordingly. In some embodiments, each R 17a , R 17b , R 17 c , R 17d , and R 17e These are independently: hydrogen, halogen, -OR 19g , -N(R 1 9g )2, and -CN; as well as one or more R 18f Place as needed Replaced C 1~6 Selected from alkyl groups; or R 15 is R 17a Together , forming a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is one or more Many R 18f It is replaced as needed; or R 16 is R 17a Together This forms a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is one or more More R 18f It is replaced as needed; or R 15 is R 17b Together This forms a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is one or More R 18f It is replaced as needed; or R 16 is R 17b and Together they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex ring is one or more R 18f It is replaced as needed.

[0168] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, with respect to salt, each R 17a , R 17b , R17c , R 17d , and R 17e is independent Use: Hydrogen, halogen, -OR 19g , and -CN; as well as one or more R 18f C replaced as needed 1~6 Selected from alkyl groups; or R 1 5 is R 17a Together with these, they form a 3- to 10-member complex ring, and here this 3- to 10-member complex An elementary ring is one or more R 18f It is replaced as needed; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 10 A member complex ring is one or more R 18f Is it replaced as needed? Iha R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to A 10-membered complex ring is one or more R 18f Is it replaced as needed? Or R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here these 3 A complex ring with ~10 members is a complex ring with one or more R units. 18f Replaced as needed In some embodiments, each R 17a , R 17b , R 17c , R 17d , and R 17e These are independently halogen, -CN, or R 15 is R 17a Together This forms a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is one or more Many R18f It is replaced as needed; or R 16 is R 17a together This forms a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is one or more More R 18f It is replaced as needed; or R 15 is R 17b and Together, they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex ring is one is more R 18f It is replaced as needed; or R 16 is R 17b Together with these, they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex ring is one or more R 18f In some embodiments, it is replaced as needed. And each R 17a , R 17b , R 17c , R 17d , and R 17e -F, -CN or R 15 is R 17a When combined with other substances, it is either -OH or methyl It is tetrahydroisoquinoline substituted as needed; or R 16 is R 17 a Together with this, it is replaced as needed with one or more -F or -CN. It forms dihydrobenzofuranyl or dihydroflopyridinyl; or R 15 is R 17b Combined with tetrahedrons, which are substituted with -OH or methyl as needed. Is it hydroisoquinoline; or R 16 is R 17b Together, one or that Dihydrobenzofuranyl or di Dihydrophlopyridinyl is formed. In some embodiments, each R 17a , R 17 b , R 17c , R 17d , and R 17e These are independently either -F or -CN.

[0169] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 17a is R 16 Together with: [ka] This forms one or more of which are independently selected from -F and -CN. Substituents are used as needed. In some embodiments, R 17b is R 16 Together with: [ka] This forms one or more of which are independently selected from -F and -CN. Substitutions are used as needed.

[0170] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, with respect to salt, each R 17a Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C 2~6 Alkenyl and C2~6 Alkinyl, these Each of them has one or more R 18f Select from those that have been replaced as needed. To be selected; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed.

[0171] In some embodiments, each R 17a Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of these is a substituent independently selected from -F and -CN, with one or more substituents. Selected from those that have been replaced as needed; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed.

[0172] In some embodiments, each R 17a Independently: Hydrogen, -F, and -CN; and C1 alkyl and C2 alkynyl, each of which is derived from -F and -CN Substituting as needed with one or more substituents that are independently selected. Selected from; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed.

[0173] In some embodiments, each R 17a These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed.

[0174] In some embodiments, each R 17a These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more substitutions selected independently of -F and -CN. Substituted as needed in the base; or R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more substitutions selected independently of -F and -CN. It is replaced as needed in the base.

[0175] In some embodiments, each R 17a These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 The 0-membered heterocycle can be optionally substituted with one or more substituents independently selected from -F. It is either replaced by or R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 The 0-membered heterocycle can be optionally substituted with one or more substituents independently selected from -F. It is being replaced.

[0176] In some embodiments, each R 17a These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R 15 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered heterocycle is required with one or more substituents independently selected from -CN. Substitutions are made accordingly; or R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered heterocycle is required with one or more substituents independently selected from -CN. It is being replaced accordingly.

[0177] In some embodiments, each R 17a These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R 16 is R 17a Together with the 3 members~ It forms a 10-membered heteroring, where this 3-membered to 10-membered heteroring has one or more R 18f It is replaced as needed. In some embodiments, each R 17a is independent and: selected from hydrogen, -F, -CN, -CH3, and -CCH; or R 1 6 is R 17a Together with these, they form a 3- to 10-member complex ring, and here this 3- to 10-member complex The elementary rings are halogen, -CN, -OH, -OCH3, -SH, -NH2, -NO2, and -N3. , C 1~6 Alkyl, and C 2~6 One or that which is selected independently of alkinyl More substituents are substituted as needed. In some embodiments, each R 1 7a The following are independently selected from: hydrogen, -F, -CN, -CH3, and -CCH; Ruiha R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, and here these 3 members ~10-membered heterocycles include halogens, -CN, and C 1~6 Alkyl, and C 2~6 Alkinil They are substituted as needed with one or more substituents that are independently selected. In some embodiments, each R 17a These are independently: hydrogen, -F, -CN, -CH3, and -CCH are selected; or R 16 is R 17a Together with 3 members It forms a 0-membered heterocycle, where this 3- to 10-membered heterocycle consists of halogens, -CN, and C1 alkyl groups. One or more substituents independently selected from C2 alkynyls are required. It is replaced as needed. In some embodiments, each R 17a Hydrogen is independent: -F, -CN, -CH3, and -CCH are selected; or R 16 is R 17 a Together with these, they form a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is - One or more independently selected from F, -CN, -CH3, and -CCH The substituents are substituted as needed. In some embodiments, each R 17a is German Standing: Selected from hydrogen, -F, -CN, -CH3, and -CCH; or R 16 is R 17a Together with these, they form a 3- to 10-member complex ring, and here these 3- to 10 members The heterocycle can be formed with one or more substituents independently selected from -F and -CN. It is replaced as needed. In some embodiments, each R 17a is independently: water Selected from -F, -CN, -CH3, and -CCH; or R 16 is R 1 7a Together with these, they form a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is - Replaced as needed with one or more substituents independently selected from F In some embodiments, each R 17a These are independently: hydrogen, -F, -CN, -C Selected from H3 and -CCH; or R 16 is R 17a Together with 3 It forms a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring can be selected independently of -CN. It is replaced as needed with one or more substituents.

[0178] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, Thus, these 3-member to 10-member complex rings can be one or more R 18f Replace as needed In some embodiments, R 16 is R 17a Together with 3 members It forms a 0-membered heterocycle, where this 3- to 10-membered heterocycle consists of halogen, -CN, -OH, - OCH3, -SH, -NH2, -NO2, -N3, C 1~6 Alkyl, and C 2~6 a Substituted as needed with one or more substituents independently selected from lukinyl In some embodiments, R 16 is R 17a Together with 3 to 10 It forms a 3- to 10-membered heterocycle, where this 3- to 10-membered heterocycle consists of halogens, -CN, and C. 1~6 Al Kill, and C 2~6One or more substitutions selected independently of alkinyl The base is replaced as needed. In some embodiments, R 16 is R 17a and Together, they form a 3- to 10-membered heterocycle, and this 3- to 10-membered heterocycle is a halogen. One or that independently selected from -CN, C1 alkyl, and C2 alkynyl More substituents are substituted as needed. In some embodiments, R 16 is R 17a Together with these, they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex The ring is one or more independently selected from -F, -CN, -CH3, and -CCH. More substituents are substituted as needed. In some embodiments, R 16 is R 17a Together with these, they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex The ring requires one or more substituents independently selected from -F and -CN. It is replaced accordingly. In some embodiments, R 16 is R 17a Together This forms a 3- to 10-membered complex ring, and this 3- to 10-membered complex ring is independent of -F. Substitutions are made as needed with one or more substituents of selection. In one embodiment, R 16 is R 17a Together with these, they form a 3-member to 10-member complex ring, Thus, this 3-member to 10-member complex ring is one or more independently selected from -CN. The substituents are substituted as needed.

[0179] In some embodiments, each R 17a Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from.

[0180] In some embodiments, each R 17a Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl and C 2~6 Alkinyl, each of these is one or the same More R 18f Those that are replaced as needed Selected from.

[0181] In some embodiments, each R 17a Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0182] In some embodiments, each R 17aIndependently: Hydrogen, halogen, -OR 19g , -N(R 19g )2, -CN, and -N3; ​​and to C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0183] In some embodiments, each R 17a Independently: Hydrogen, halogen, -OR 19g , -CN, and -N3; ​​and C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0184] In some embodiments, each R 17a Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0185] In some embodiments, each R 17a Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~3 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0186] In some embodiments, each R 17a Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkynnyl, each of which is a halogen or C Substituting as needed with one or more substituents independently selected from N things Selected from.

[0187] In some embodiments, each R 17a Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl and C 2~6 Alkinyl Selected from.

[0188] In some embodiments, each R 17a Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~6 Alkinyl Selected from.

[0189] In some embodiments, each R 17a Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkinyl Selected from.

[0190] In some embodiments, each R 17a Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C2 alkynyl Selected from.

[0191] In some embodiments, each R 17a Independently: Hydrogen, -F, and -CN; and C1 alkyl and C2 alkynyl Selected from.

[0192] In some embodiments, each R 17a These are independently: hydrogen, -CN, -F, -CH3 Selected from , and -CCH.

[0193] In some embodiments, each R 17a These are independently: hydrogen, -CN, -F, and - Selected from CH3. In some embodiments, each R 17a Independently: hydrogen, - Selected from CN, -F, and -CCH. In some embodiments, each R 17a These are independently selected from hydrogen, -CN, -CCH, and -CH3. Several implementations In terms of form, each R 17a These are independently selected from: hydrogen, -CCH, -F, and -CH3. In some embodiments, each R 17a These are independently: hydrogen, -CCH, -F, And selected from -CH3.

[0194] In some embodiments, each R 17a These are independently derived from: hydrogen, -CN, and -F. Selected. In some embodiments, each R 17a These are independently: hydrogen, -CH3, and Selected from -F. In some embodiments, each R 17a Independently: hydrogen, -CH3 and -CN are selected. In some embodiments, each R17a is German The following are selected from hydrogen, -CCH, and -F. In some embodiments, each R 17a The elements are independently selected from hydrogen, -CCH, and -CN.

[0195] In some embodiments, each R 17a These are independently selected from hydrogen and -CN. In some embodiments, each R 17a These are independently selected from hydrogen and -F. In some embodiments, each R 17a Independently, one can choose from hydrogen and -CH3. In some embodiments, each R 17a These are independently derived from: hydrogen and -CCH Selected.

[0196] In some embodiments, each R 17a It is independently selected from hydrogen. Some In the embodiment, each R 17a This is independently selected from :-F. Several embodiments In each R 17a This is independently selected from :-CN. In some embodiments, , each R 17a R is independently selected from -CH3. In some embodiments, each R 17a It is independently selected from :-CCH.

[0197] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, with respect to salt, each R 17b Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed.

[0198] In some embodiments, each R 17b Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed.

[0199] In some embodiments, each R 17b Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of these is a substituent independently selected from -F and -CN, with one or more substituents. Those that are replaced as needed Selected from; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed.

[0200] In some embodiments, each R 17b Independently: Hydrogen, -F, and -CN; and C1 alkyl and C2 alkynyl, each of which is derived from -F and -CN Substituting as needed with one or more substituents that are independently selected. Selected from; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18fAnd it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed.

[0201] In some embodiments, each R 17b These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f And it is replaced as needed; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more R 18f It is replaced as needed.

[0202] In some embodiments, each R 17b These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more substitutions selected independently of -F and -CN. Substituted as needed in the base; or R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered complex ring is one or more substitutions selected independently of -F and -CN. It is replaced as needed in the base.

[0203] In some embodiments, each R 17b These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 The 0-membered heterocycle can be optionally substituted with one or more substituents independently selected from -F. It is either replaced by or R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 The 0-membered heterocycle can be optionally substituted with one or more substituents independently selected from -F. It is being replaced.

[0204] In some embodiments, each R 17b These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R 15 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered heterocycle is required with one or more substituents independently selected from -CN. Substitutions are made accordingly; or R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here this 3-member to 1 A 0-membered heterocycle is required with one or more substituents independently selected from -CN. It is being replaced accordingly.

[0205] In some embodiments, each R 17b These are independently: hydrogen, -F, -CN, -CH3 , and -CCH are selected; or R16 is R 17b Together with the 3 members~ It forms a 10-membered heteroring, where this 3-membered to 10-membered heteroring has one or more R 18f It is replaced as needed. In some embodiments, each R 17b is independent and: selected from hydrogen, -F, -CN, -CH3, and -CCH; or R 1 6 is R 17b Together with these, they form a 3- to 10-member complex ring, and here this 3- to 10-member complex The elementary rings are halogen, -CN, -OH, -OCH3, -SH, -NH2, -NO2, and -N3. , C 1~6 Alkyl, and C 2~6 One or that which is selected independently of alkinyl More substituents are substituted as needed. In some embodiments, each R 1 7b The following are independently selected from: hydrogen, -F, -CN, -CH3, and -CCH; Ruiha R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, and here these 3 members ~10-membered heterocycles include halogens, -CN, and C 1~6 Alkyl, and C 2~6 Alkinil They are substituted as needed with one or more substituents that are independently selected. In some embodiments, each R 17b These are independently: hydrogen, -F, -CN, -CH3, and -CCH are selected; or R 16 is R 17b Together with 3 members It forms a 0-membered heterocycle, where this 3- to 10-membered heterocycle consists of halogens, -CN, and C1 alkyl groups. One or more substituents independently selected from C2 alkynyls are required. It is replaced as needed. In some embodiments, each R 17b Hydrogen is independent: -F, -CN, -CH3, and -CCH are selected; or R 16 is R 17 b Together with these, they form a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is - One or more independently selected from F, -CN, -CH3, and -CCH The substituents are substituted as needed. In some embodiments, each R 17b is German Standing: Selected from hydrogen, -F, -CN, -CH3, and -CCH; or R 16 is R 17b Together with these, they form a 3- to 10-member complex ring, and here these 3- to 10 members The heterocycle can be formed with one or more substituents independently selected from -F and -CN. It is replaced as needed. In some embodiments, each R 17b is independently: water Selected from -F, -CN, -CH3, and -CCH; or R 16 is R 1 7b Together with these, they form a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring is - Replaced as needed with one or more substituents independently selected from F In some embodiments, each R 17b These are independently: hydrogen, -F, -CN, -C Selected from H3 and -CCH; or R 16 is R 17b Together with 3 It forms a 3- to 10-membered complex ring, where this 3- to 10-membered complex ring can be selected independently of -CN. It is replaced as needed with one or more substituents.

[0206] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, Thus, these 3-member to 10-member complex rings can be one or more R 18f Replace as needed In some embodiments, R 16 is R 17b Together with 3 members It forms a 0-membered heterocycle, where this 3- to 10-membered heterocycle consists of halogen, -CN, -OH, - OCH3, -SH, -NH2, -NO2, -N3, C 1~6 Alkyl, and C 2~6 a Substituted as needed with one or more substituents independently selected from lukinyl In some embodiments, R 16 is R 17b Together with 3 to 10 It forms a 3- to 10-membered heterocycle, where this 3- to 10-membered heterocycle consists of halogens, -CN, and C. 1~6 Al Kill, and C 2~6 One or more substitutions selected independently of alkinyl The base is replaced as needed. In some embodiments, R 16 is R 17b and Together, they form a 3- to 10-membered heterocycle, and this 3- to 10-membered heterocycle is a halogen. One or that independently selected from -CN, C1 alkyl, and C2 alkynyl More substituents are substituted as needed. In some embodiments, R 16 is R 17b Together with these, they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex The ring is one or more independently selected from -F, -CN, -CH3, and -CCH. More substituents are substituted as needed. In some embodiments, R 16 is R 17b Together with these, they form a 3- to 10-membered complex ring, and here this 3- to 10-membered complex The ring requires one or more substituents independently selected from -F and -CN. It is replaced accordingly. In some embodiments, R 16 is R 17b Together This forms a 3- to 10-membered complex ring, and this 3- to 10-membered complex ring is independent of -F. Substitutions are made as needed with one or more substituents of selection. In one embodiment, R 16 is R 17b Together with these, they form a 3-member to 10-member complex ring, Thus, this 3-member to 10-member complex ring is one or more independently selected from -CN. The substituents are substituted as needed.

[0207] In some embodiments, each R 17b Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from.

[0208] In some embodiments, each R 17b Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl and C 2~6 Alkinyl, each of these is one or the same More R 18f Those that are replaced as needed Selected from.

[0209] In some embodiments, each R 17b Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, -N3; C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0210] In some embodiments, each R 17b Independently: Hydrogen, halogen, -OR 19g , -N(R 19g )2, -CN, and -N3; ​​and to C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0211] In some embodiments, each R 17b Independently: Hydrogen, halogen, -OR 19g , -CN, and -N3; ​​and C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0212] In some embodiments, each R 17b Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0213] In some embodiments, each R 17b Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~3 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0214] In some embodiments, each R 17b Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkynnyl, each of which is a halogen or C Substituting as needed with one or more substituents independently selected from N things Selected from.

[0215] In some embodiments, each R 17b Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl and C 2~6 Alkinyl Selected from.

[0216] In some embodiments, each R 17b Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~6 Alkinyl Selected from.

[0217] In some embodiments, each R 17b Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkinyl Selected from.

[0218] In some embodiments, each R 17b Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C2 alkynyl Selected from.

[0219] In some embodiments, each R 17b Independently: Hydrogen, -F, and -CN; and C1 alkyl and C2 alkynyl Selected from.

[0220] In some embodiments, each R 17b These are independently: hydrogen, -CN, -F, -CH3 Selected from , and -CCH.

[0221] In some embodiments, each R 17b These are independently: hydrogen, -CN, -F, and - Selected from CH3. In some embodiments, each R 17b Independently: hydrogen, - Selected from CN, -F, and -CCH. In some embodiments, each R 17b These are independently selected from hydrogen, -CN, -CCH, and -CH3. Several implementations In terms of form, each R 17b These are independently selected from: hydrogen, -CCH, -F, and -CH3. In some embodiments, each R 17b These are independently: hydrogen, -CCH, -F, And selected from -CH3.

[0222] In some embodiments, each R 17b These are independently derived from: hydrogen, -CN, and -F. Selected. In some embodiments, each R 17b These are independently: hydrogen, -CH3, and Selected from -F. In some embodiments, each R 17b Independently: hydrogen, -CH3 and -CN are selected. In some embodiments, each R 17b is German The following are selected from hydrogen, -CCH, and -F. In some embodiments, each R 17b The elements are independently selected from hydrogen, -CCH, and -CN.

[0223] In some embodiments, each R 17b These are independently selected from hydrogen and -CN. In some embodiments, each R 17b These are independently selected from hydrogen and -F. In some embodiments, each R 17b Independently, one can choose from hydrogen and -CH3. In some embodiments, each R 17b These are independently derived from: hydrogen and -CCH Selected.

[0224] In some embodiments, each R 17b It is independently selected from hydrogen. Some In the embodiment, each R 17b This is independently selected from :-F. Several embodiments In each R 17b This is independently selected from :-CN. In some embodiments, , each R 17b R is independently selected from -CH3. In some embodiments, each R 17b It is independently selected from :-CCH.

[0225] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, with respect to salt, each R 17c Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from.

[0226] In some embodiments, each R 17c Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from.

[0227] In some embodiments, each R 17c Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl and C 2~6 Alkinyl, each of these is one or the same More R 18f Those that are replaced as needed Selected from.

[0228] In some embodiments, each R 17c Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0229] In some embodiments, each R 17c Independently: Hydrogen, halogen, -OR 19g , -N(R 19g )2, -CN, and -N3; ​​and to C 1~6 Alkyl and C2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0230] In some embodiments, each R 17c Independently: Hydrogen, halogen, -OR 19g , -CN, and -N3; ​​and C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0231] In some embodiments, each R 17c Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0232] In some embodiments, each R 17c Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~3 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0233] In some embodiments, each R 17c Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkynnyl, each of which is a halogen or C Substituting as needed with one or more substituents independently selected from N things Selected from.

[0234] In some embodiments, each R 17c Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl and C 2~6 Alkinyl Selected from.

[0235] In some embodiments, each R 17c Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~6 Alkinyl Selected from.

[0236] In some embodiments, each R 17c Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkinyl Selected from.

[0237] In some embodiments, each R 17c Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C2 alkynyl Selected from.

[0238] In some embodiments, each R 17c Independently: Hydrogen, -F, and -CN; and C1 alkyl and C2 alkynyl Selected from.

[0239] In some embodiments, each R 17c These are independently: hydrogen, -CN, -F, -CH3 Selected from , and -CCH.

[0240] In some embodiments, each R 17c These are independently: hydrogen, -CN, -F, and - Selected from CH3. In some embodiments, each R 17c Independently: hydrogen, - Selected from CN, -F, and -CCH. In some embodiments, each R 17c These are independently selected from hydrogen, -CN, -CCH, and -CH3. Several implementations In terms of form, each R 17c These are independently selected from: hydrogen, -CCH, -F, and -CH3. In some embodiments, each R 17c These are independently: hydrogen, -CCH, -F, And selected from -CH3.

[0241] In some embodiments, each R 17c These are independently derived from: hydrogen, -CN, and -F. Selected. In some embodiments, each R 17c These are independently: hydrogen, -CH3, and Selected from -F. In some embodiments, each R 17c Independently: hydrogen, -CH3 and -CN are selected. In some embodiments, each R 17c is German The following are selected from hydrogen, -CCH, and -F. In some embodiments, each R 17c The elements are independently selected from hydrogen, -CCH, and -CN.

[0242] In some embodiments, each R 17c These are independently selected from hydrogen and -CN. In some embodiments, each R 17c These are independently selected from hydrogen and -F. In some embodiments, each R 17c Independently, one can choose from hydrogen and -CH3. In some embodiments, each R 17c These are independently derived from: hydrogen and -CCH Selected.

[0243] In some embodiments, each R 17c It is independently selected from hydrogen. Some In the embodiment, each R 17c This is independently selected from :-F. Several embodiments In each R 17c This is independently selected from :-CN. In some embodiments, , each R 17c R is independently selected from -CH3. In some embodiments, each R 17c It is independently selected from :-CCH.

[0244] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, with respect to salt, each R 17d Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from.

[0245] In some embodiments, each R 17d Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from.

[0246] In some embodiments, each R 17d Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl and C 2~6 Alkinyl, each of these is one or the same More R 18f Those that are replaced as needed Selected from.

[0247] In some embodiments, each R 17d Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0248] In some embodiments, each R 17d Independently: Hydrogen, halogen, -OR 19g , -N(R 19g )2, -CN, and -N3; ​​and to C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0249] In some embodiments, each R 17d Independently: Hydrogen, halogen, -OR 19g , -CN, and -N3; ​​and C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0250] In some embodiments, each R 17d Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0251] In some embodiments, each R 17d Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~3 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0252] In some embodiments, each R 17d Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkynnyl, each of which is a halogen or C Substituting as needed with one or more substituents independently selected from N things Selected from.

[0253] In some embodiments, each R 17d Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl and C 2~6 Alkinyl Selected from.

[0254] In some embodiments, each R 17d Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~6 Alkinyl Selected from.

[0255] In some embodiments, each R 17d Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkinyl Selected from.

[0256] In some embodiments, each R 17d Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C2 alkynyl Selected from.

[0257] In some embodiments, each R 17d Independently: Hydrogen, -F, and -CN; and C1 alkyl and C2 alkynyl Selected from.

[0258] In some embodiments, each R 17d These are independently: hydrogen, -CN, -F, -CH3 Selected from , and -CCH.

[0259] In some embodiments, each R 17d These are independently: hydrogen, -CN, -F, and - Selected from CH3. In some embodiments, each R 17d Independently: hydrogen, - Selected from CN, -F, and -CCH. In some embodiments, each R 17d These are independently selected from hydrogen, -CN, -CCH, and -CH3. Several implementations In terms of form, each R 17d These are independently selected from: hydrogen, -CCH, -F, and -CH3. In some embodiments, each R 17d These are independently: hydrogen, -CCH, -F, And selected from -CH3.

[0260] In some embodiments, each R 17d These are independently derived from: hydrogen, -CN, and -F. Selected. In some embodiments, each R 17d These are independently: hydrogen, -CH3, and Selected from -F. In some embodiments, each R 17d Independently: hydrogen, -CH3 and -CN are selected. In some embodiments, each R 17d is German The following are selected from hydrogen, -CCH, and -F. In some embodiments, each R 17d The elements are independently selected from hydrogen, -CCH, and -CN.

[0261] In some embodiments, each R 17d These are independently selected from hydrogen and -CN. In some embodiments, each R 17d These are independently selected from hydrogen and -F. In some embodiments, each R 17d Independently, one can choose from hydrogen and -CH3. In some embodiments, each R 17d These are independently derived from: hydrogen and -CCH Selected.

[0262] In some embodiments, each R 17d It is independently selected from hydrogen. Some In the embodiment, each R 17d This is independently selected from :-F. Several embodiments In each R 17d This is independently selected from :-CN. In some embodiments, , each R 17d R is independently selected from -CH3. In some embodiments, each R 17d It is independently selected from :-CCH.

[0263] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, with respect to salt, each R 17e Independently: Hydrogen, halogen, -OR 19g , -SR19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from.

[0264] In some embodiments, each R 17e Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl, C 2~6 Alkenyl and C 2~6 Alkinyl, these Each of them has one or more R 18f Those that are replaced as needed Selected from.

[0265] In some embodiments, each R 17e Independently: Hydrogen, halogen, -OR 19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl and C 2~6 Alkinyl, each of these is one or the same More R 18f Those that are replaced as needed Selected from.

[0266] In some embodiments, each R 17e Independently: Hydrogen, halogen, -OR19g , -SR 19g , -N(R 19g )2, -NO2, -C N, and -N3; ​​as C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0267] In some embodiments, each R 17e Independently: Hydrogen, halogen, -OR 19g , -N(R 19g )2, -CN, and -N3; ​​and to C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0268] In some embodiments, each R 17e Independently: Hydrogen, halogen, -OR 19g , -CN, and -N3; ​​and C 1~6 Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0269] In some embodiments, each R 17e Independently: Hydrogen, halogens, and -CN; as well C 1~6Alkyl and C 2~6 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0270] In some embodiments, each R 17e Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~3 Alkynnyl, each of which is a halogen or It is optionally replaced with one or more substituents selected independently of CN. things that Selected from.

[0271] In some embodiments, each R 17e Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkynnyl, each of which is a halogen or C Substituting as needed with one or more substituents independently selected from N things Selected from.

[0272] In some embodiments, each R 17e Independently: Hydrogen, halogens, and -CN; as well C 1~6 Alkyl and C 2~6 Alkinyl Selected from.

[0273] In some embodiments, each R 17e Independently: Hydrogen, halogens, and -CN; as well C 1~3 Alkyl and C 2~6Alkinyl Selected from.

[0274] In some embodiments, each R 17e Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C 2~3 Alkinyl Selected from.

[0275] In some embodiments, each R 17e Independently: Hydrogen, halogens, and -CN; as well C1 alkyl and C2 alkynyl Selected from.

[0276] In some embodiments, each R 17e Independently: Hydrogen, -F, and -CN; and C1 alkyl and C2 alkynyl Selected from.

[0277] In some embodiments, each R 17e These are independently: hydrogen, -CN, -F, -CH3 Selected from , and -CCH.

[0278] In some embodiments, each R 17e These are independently: hydrogen, -CN, -F, and - Selected from CH3. In some embodiments, each R 17e Independently: hydrogen, - Selected from CN, -F, and -CCH. In some embodiments, each R 17e These are independently selected from hydrogen, -CN, -CCH, and -CH3. Several implementations In terms of form, each R 17e These are independently selected from: hydrogen, -CCH, -F, and -CH3. In some embodiments, each R 17eThese are independently: hydrogen, -CCH, -F, And selected from -CH3.

[0279] In some embodiments, each R 17e These are independently derived from: hydrogen, -CN, and -F. Selected. In some embodiments, each R 17e These are independently: hydrogen, -CH3, and Selected from -F. In some embodiments, each R 17e Independently: hydrogen, -CH3 and -CN are selected. In some embodiments, each R 17e is German The following are selected from hydrogen, -CCH, and -F. In some embodiments, each R 17e The elements are independently selected from hydrogen, -CCH, and -CN.

[0280] In some embodiments, each R 17e These are independently selected from hydrogen and -CN. In some embodiments, each R 17e These are independently selected from hydrogen and -F. In some embodiments, each R 17e Independently, one can choose from hydrogen and -CH3. In some embodiments, each R 17e These are independently derived from: hydrogen and -CCH Selected.

[0281] In some embodiments, each R 17e It is independently selected from hydrogen. Some In the embodiment, each R 17e This is independently selected from :-F. Several embodiments In each R 17e This is independently selected from :-CN. In some embodiments, , each R 17eR is independently selected from -CH3. In some embodiments, each R 17e It is independently selected from :-CCH.

[0282] In certain embodiments, a compound of formula (II), formula (II-A), or formula (II') Or, regarding salt, R 18a , R 18b , R 18c , R 18d , R 18e , and R 18 f Each of these may be any suitable functional group known to those skilled in the art. Several i...

Claims

[Claim 1] The invention described in the specification.

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