Method for producing oligonucleotide compounds

JP2026094241APending Publication Date: 2026-06-09NIPPON SHINYAKU CO LTD
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
NIPPON SHINYAKU CO LTD
Filing Date
2026-02-24
Publication Date
2026-06-09

AI Technical Summary

Benefits of technology

【0022】 オリゴ核酸化合物は、2個~複数個のヌクレオシドユニットがリン結合を介して連なった構造を有する化合物である。オリゴ核酸化合物を製造するためには、何度も縮合反応を行い、隣接するヌクレオシドユニット間でリン結合を形成する必要がある。 本発明によれば、効率的にリン結合を形成しうるため、結果的にオリゴ核酸化合物の製造時間を短くすることが期待できる。

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Abstract

This invention provides a method for producing oligonucleotide compounds. [Solution] A method for producing an oligonucleotide compound, comprising (1) treating a compound of formula [A-1] and a compound of formula [B-1] with a condensing agent in the presence of a base, and (2) treating them with an oxidizing agent and an organic amine to obtain a compound of formula [C-1]. JPEG2026094241000129.jpg33163
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