Fibroblast-activating protein ligands for targeted delivery applications
JP2026094286APending Publication Date: 2026-06-09フィロケム·アーゲー
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- フィロケム·アーゲー
- Filing Date
- 2026-02-27
- Publication Date
- 2026-06-09
AI Technical Summary
Benefits of technology
【0009】 本発明者らは、標的化の用途に適当な線維芽細胞活性化タンパク質(FAP)の新規な有機リガンドを見出した。本発明による化合物(リガンドまたはバインダーとも称される)は、以下の構造を有する小さい結合部分Aを含む:
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Figure 2026094286000001_ABST
Abstract
This provides ligands for fibroblast-activating proteins (FAPs) suitable for targeted applications. [Solution] The present invention provides ligands for fibroblast-activating protein (FAP) for the active delivery of various payloads (e.g., cytotoxic drugs, radionuclides, fluorophores, proteins, and immunomodulators) at disease sites. In particular, the present invention provides FAP ligands for targeted applications, especially for diagnostic and / or therapeutic or surgical methods related to diseases or disorders such as cancer, inflammation, or other diseases characterized by FAP overexpression.
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