IKAROS Zinc Finger Family Degrading Agent and its Use
JP2026095542APending Publication Date: 2026-06-11GILEAD SCIENCES INC
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- GILEAD SCIENCES INC
- Filing Date
- 2026-03-30
- Publication Date
- 2026-06-11
Smart Images

Figure 2026095542000001 
Figure 2026095542000002 
Figure 2026095542000003
Abstract
To provide a method for treating a disease. [Solution] This disclosure generally relates to compounds that bind to IKAROS family zinc finger (IKZF) proteins such as IKZF2 (Helios) and / or IKZF4 (Eos) and act as degrading agents thereof. This disclosure further relates to the use of compounds for the preparation of pharmaceuticals for the treatment of diseases and / or conditions, including cancer, through the binding and degradation of IKZF proteins such as IKZF2 and / or IKZF4. Surprisingly, remarkable effects are achieved according to the present invention, as described in detail and specifically demonstrated herein, and these remarkable effects could not be readily predicted by those skilled in the art from the prior art.
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Claims
[Claim 1] The invention described in the specification.