A method for forming particles by continuous droplet formation and dehydration.

JP2026097972APending Publication Date: 2026-06-16ハロザイム ハイパーコンインコーポレイテッド
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
ハロザイム ハイパーコンインコーポレイテッド
Filing Date
2026-03-06
Publication Date
2026-06-16

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Abstract

This invention provides a method for forming pharmaceutically appropriate particles that can be used for therapeutic purposes. [Solution] The method comprises: a) providing a first aqueous liquid containing a therapeutic biological agent; b) contacting the first aqueous liquid containing the therapeutic biological agent with a second organic liquid by a continuous process to form a mixture containing droplets of the aqueous liquid, wherein the droplets of the aqueous liquid contain the therapeutic biological agent; c) dehydrating the droplets of the aqueous liquid in the mixture; and d) removing the first aqueous liquid and the second organic liquid from the mixture to form particles containing the therapeutic biological agent, wherein the particles contain less than about 10% internal void space, and the circularity of the particles is about 0.80 to about 1.00 after removing the first aqueous liquid and the second organic liquid from the mixture.
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Claims

[Claim 1] A method for forming particles, a) To provide a first aqueous liquid containing a therapeutic biological agent; b) A continuous process of contacting the first aqueous liquid containing the therapeutic biological agent with a second organic liquid to form a mixture containing droplets of the aqueous liquid, wherein the droplets of the aqueous liquid contain the therapeutic biological agent; c) Dehydrating the droplets of the aqueous liquid in the mixture; and d) Removing the first aqueous liquid and the second organic liquid from the mixture to form particles containing the therapeutic biological agent, wherein the particles contain less than about 10% internal void space, and the circularity of the particles is about 0.80 to about 1.00 after removing the first aqueous liquid and the second organic liquid from the mixture. A method that includes this.