Composition

Abstract

This invention helps to suppress the browning of compositions containing tannic acid as an active ingredient over a longer period of time. [Solution] The composition comprises tannic acid, ethanol, and citric acid, with an ethanol content of 10% by mass or more, and a pH of 4.0 or higher and 4.6 or lower.

Description

Technical Field

[0006] ,

[0001] The present invention relates to a composition containing tannic acid as an active ingredient.

Background Art

[0002] Tannic acid is known as a natural compound that inactivates allergenic proteins that cause allergies. Patent Document 1 discloses a composition containing tannic acid as an active ingredient. The composition of Patent Document 1 is characterized by being formulated with tannic acid, water, and a predetermined polyoxyethylene alkyl ether sulfate and having a predetermined pH.

Prior Art Documents

Patent Documents

[0003]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0004] By the way, in a composition containing tannic acid as an active ingredient, there is a problem that tannic acid changes and undergoes browning due to metal ions, light, oxidation, etc. Browning of the composition causes the user to have the impression that the quality has deteriorated. Also, when the composition is used by adhering it to an object, browning of the composition also causes soiling of the object.

[0005] Here, in a composition containing tannic acid and water as in Patent Document 1, browning sometimes occurred during long-term storage for four weeks or more. Therefore, there is a need for a composition in which the browning of the composition over time is more effectively suppressed.

[0006] The present invention has been made in view of such circumstances, and an object thereof is to provide a composition in which the browning of a composition containing tannic acid as an active ingredient is suppressed for a longer period of time. [Means for solving the problem]

[0007] The composition for solving the above problems comprises tannic acid, ethanol, and citric acid, wherein the amount of ethanol is 10% by mass or more, and the pH is between 4.0 and 4.6.

[0008] In the above composition, it is preferable that the amount of citric acid is 0.09% by mass or less. It is preferable that the above composition further contains a mite repellent component. [Effects of the Invention]

[0009] According to the composition of the present invention, the browning of compositions containing tannic acid as an active ingredient over time can be suppressed for a longer period of time. [Modes for carrying out the invention]

[0010] The composition of this embodiment will be described in detail below. The composition of this embodiment comprises tannic acid, ethanol, and citric acid. <Tannic acid> Tannic acid is an astringent polyphenol found in plant leaves and other parts, and is included as an active ingredient to inactivate allergen proteins. Examples of tannic acid include hydrolyzed tannins obtained from gallnuts, galls, sumac, tara, chestnut, myrobalan, oak, dividivi, algarovia, and geranium, as well as condensed tannins obtained from gambia, gebracho, mimosa, mangrove, hemlock, spruce, burmese, oak bark, and persimmon tannin.

[0011] The tannic acid incorporated into the composition is not particularly limited, but it is preferably tannic acid as described in the Japanese Pharmacopoeia (tannin obtained from gallnuts or galls) and tannic acid with CAS registry number 1401-55-4. Tannic acid can be used alone or in combination of two or more as appropriate. When using two or more types of tannic acid, it is preferable that at least one of the tannic acids is tannic acid as described in the Japanese Pharmacopoeia or tannic acid with CAS registry number 1401-55-4. Examples include G tannic acid from DSP Gokyo Food & Chemical Co., Ltd., ALSOK01 from Ajinomoto OmniChem, tannic acid from Kokusan Yakuhin Kogyo Co., Ltd., and tannic acid from Fuji Chemical Industry Co., Ltd.

[0012] The amount of tannic acid is preferably, for example, 0.0001% by mass or more and 0.1% by mass or less, more preferably 0.001% by mass or more and 0.05% by mass or less, and even more preferably 0.005% by mass or more and 0.03% by mass or less. When the amount is 0.0001% by mass or more, inactivation ability against multiple types of allergens is easily obtained.

[0013] <Ethanol> Ethanol is added as a solvent. The amount of ethanol added is 10% by mass or more. Preferably, the amount of ethanol added is 10% by mass or more and 70% by mass or less, more preferably 20% by mass or more and 60% by mass or less, and even more preferably 30% by mass or more and 50% by mass or less. When the amount of ethanol added is 10% by mass or more, the antibacterial and disinfectant effects are more easily obtained. In addition, the mite repellent components described later can be dissolved. As a specific example of ethanol, for example, ethanol with a concentration of 99% by volume (hereinafter also referred to as "99% ethanol") can be used.

[0014] <Citric acid> Citric acid is added to suppress browning of the composition over time. The amount of citric acid in the composition is preferably, for example, 0.09% by mass or less. Citric acid may also be added as a citrate. Examples of citrates include sodium salt, potassium salt, magnesium salt, and calcium salt of citric acid. These citrates can be used individually or in appropriate combinations of two or more.

[0015] The pH of the composition is between 4.0 and 4.6. Compositions containing tannic acid as an active ingredient tend to brown strongly when the pH is above 4.0. Therefore, when the pH is above 4.0, a greater browning inhibitory effect based on citric acid as a browning inhibitory component can be obtained. Furthermore, when the pH of the composition is between 4.0 and 4.6, the browning inhibitory effect of citric acid is more easily obtained.

[0016] <Mite repellent ingredients> In addition to the above-mentioned components, the composition preferably contains a mite repellent component. In this case, an effect of keeping mites away can be expected. The amount of mite repellent component in the composition is preferably, for example, 0.05% by mass or more and 5% by mass or less, more preferably 0.5% by mass or more and 3.5% by mass or less, and even more preferably 1% by mass or more and 2.5% by mass or less.

[0017] As mite repellent components, known components can be appropriately adopted, such as fenitrothion, fenthion, dichlorvos, diazinon, propetamphos, phenothrin, permethrin, cyphenothrin, phthalthrin, natural pyrethrin, propoxur, methoxadiazone, amidoflumet, phenyl salicylate, benzyl benzoate, isobornyl thiocyanoacetate, menthol, menthol derivatives, α,β-pinene, α,β-terpinol, limonene, citronellal, linalool, citral, carboxylic acid esters, eugenol, thymol, citronellol, benzyl isothiosanate, vetiver oil, patchouli oil, clove oil, and other essential oil components. Specific examples of menthol include 1-menthol and d1-menthol. Specific examples of menthol derivatives include, for example, menthyl lactate, 1-menthyl glyceryl ether, 1-menthyl glucoside, 1-menthyl hydroxybutyrate, menthoxypropanediol, and menthoxyfuran. These mite repellent components can be used individually or in appropriate combinations of two or more.

[0018] <Other ingredients> The composition can be manufactured by mixing and stirring other desired components using conventional methods. Furthermore, as long as the effects of the present invention are not impaired, functional components such as polysaccharides, surfactants, polyphenols other than tannic acid, solvents other than ethanol, oily components, water-soluble polymers, silicone derivatives, humectants, hydrotropes, deodorizing components, pH adjusters, preservatives / bactericides, UV absorbers, antioxidants, dyes, fragrances, etc., can be incorporated. Specific examples of these are given below.

[0019] Examples of polysaccharides include agar, gellan gum (including deacylated gellan gum), alginic acid, and pullulan (including cholesterol-substituted pullulan). When the composition contains one or more polysaccharides selected from agar, gellan gum, alginic acid, and pullulan, it can be expected that when the composition is applied as a liquid (spray) for manual spray containers such as trigger-type pump containers, it will prevent foaming in the container during storage and use, and suppress foaming during spraying.

[0020] Examples of surfactants include anionic surfactants such as polyoxyethylene alkyl ether sulfate, alkyl sulfate ester salt, sodium polyoxyethylene alkyl ether sulfate (average number of added moles less than 1.5), sodium polyoxyethylene alkyl ether sulfate (alkyl group with 11 or fewer carbon atoms, or 15 or more carbon atoms), alkylamide sulfate, polyoxyethylene alkylamide ether sulfate, α-olefin sulfonate, monoalkyl phosphate ester salt, polyoxyethylene monoalkyl ether phosphate ester salt, α-sulfo fatty acid methyl ester salt, monoalkyl sulfosuccinate, polyoxyethylene alkyl ether sulfosuccinate, fatty acid soap, polyoxyethylene alkyl ether carboxylate, N-acyl amino acid salt, acyl glutamate, acyl methyl taurate salt, acyl methyl taurate salt, etc.; polyoxyethylene fatty acid ester, propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene propylene glycol mono fatty acid ester, sorbitan Nonionic surfactants such as tan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sucrose fatty acid esters, polyoxyethylene sorbitol fatty acid esters, pentaerythritol fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene alkyl allyl ethers, polyoxyethylene alkyl thio ethers, polyoxyethylene hydrogenated castor oil, alkanolamides, dimethylalkylamine oxide, bis-(2-hydroxyethyl)alkylamine oxide, alkylamidopropyl dimethylamine oxide pluronic surfactants, polyoxyethylene fatty acid amides, polyoxyethylene alkylamines, and ethylene oxide derivatives of alkylphenol formalin condensates; amphoteric surfactants such as alkyldimethylaminoacetic acid betaine, alkylamidopropyl dimethylacetic acid betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-cocoamidopropyl-N,N-dimethyl-N-β-hydroxypropylaminosulfonate, and 2-(N-2-hydroxyalkyl-N-methylamino)ethyl phosphate;Examples of cationic surfactants include monoalkyltrimethylammonium salts, dialkyldimethylammonium salts, alkylbenzyldimethylammonium salts, alkylamine acetates, etc. These surfactants can be used alone or in appropriate combinations of two or more.;

[0021] Examples of polyphenols other than tannic acid include anthocyanins, catechins, cacao polyphenols, rutin, ferulic acid, chlorogenic acid, curcumin, gingerol, etc. These polyphenols can be used alone or in appropriate combinations of two or more. Note that polyphenols include food materials such as sugarcane extracts, etc.

[0022] Other solvents besides ethanol include, for example, water, methanol, alcohols such as n-propanol, isopropanol, n-butanol, isobutanol, dic-butanol, tertiary-butanol, and n-hexanol, ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, polyoxyethylene glycol 200, polyoxyethylene glycol 400, propylene glycol, dipropylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monohexyl ether, ethylene glycol mono-2-ethylhexyl ether, and diethylene glycol monoethyl ether. Examples of glycol ethers include ethyl ether, diethylene glycol monobutyl ether, diethylene glycol monohexyl ether, diethylene glycol mono-2-ethylhexyl ether, triethylene glycol monobutyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol mono-n-propyl ether, propylene glycol mono-n-butyl ether, propylene glycol mono-n-butyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, tripropylene glycol monomethyl ether, 3-methoxybutanol, 3-methyl-3-methoxybutanol, and other glycol ethers. These solvents can be used individually or in appropriate combinations of two or more.

[0023] Examples of the oily components include hydrocarbons such as ozokerite, liquid paraffin, squalene, and petrolatum; ester oils such as isopropyl myristate, ethyl oleate, octyl stearate, cetyl 2-ethylhexanoate, isononyl isononanoate, octyl palmitate, ethylene glycol dioleate, glyceryl triisostearate, cetyl lactate, diisopropyl adipate, and cholesteryl isostearate; and oils and fats such as avocado oil, almond oil, olive oil, grape seed oil, rice bran oil, rice germ oil, evening primrose oil, camellia oil, sasanka oil, macadamia nut oil, meadowfoam oil, jojoba oil, shea butter, carnauba wax, candelilla wax, egg yolk oil, horse fat, lanolin, and beeswax. These oily components can be used alone or in appropriate combinations of two or more.

[0024] Examples of the water-soluble polymers include cellulose derivatives such as methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, quaternized hydroxyethyl cellulose, and carboxymethyl cellulose, and salts thereof with sodium, potassium, etc. (e.g., sodium carboxymethyl cellulose, etc.); carrageenan, fenugreek gum, tara gum, xanthan gum, starch, konjac, gum arabic, polyvinyl pyrrolidone, acrylic water-soluble polymers, methacrylic water-soluble polymers, and water-soluble nylon. These water-soluble polymers can be used alone or in appropriate combinations of two or more.

[0025] Examples of silicone derivatives include dimethylpolysiloxane, highly polymerized dimethylpolysiloxane, polyether-modified silicone, amino-modified silicone, methylphenyl-modified silicone, fatty acid-modified silicone, alcohol-modified silicone, alkoxy-modified silicone, epoxy-modified silicone, fluorine-modified silicone, cyclic silicone, alkyl-modified silicone, silicone derivatives obtained by condensing polypeptides and silicones, and silicone derivatives obtained by introducing anionic groups such as phosphate groups into silicones. These silicone derivatives can be used individually or in appropriate combinations of two or more.

[0026] Examples of humectants include lanolin alcohol, reduced lanolin, aminopropylethyldimethylammonium ethyl sulfate, lanolin acetate, polyethylene glycol lanolin fatty acid, polyoxyethylene lanolin alcohol, pyrrolidone carboxylate, polyoxyethylene glycol, polyoxyethylene hydrogenated castor oil pyroglutamate isostearate, and glyceryl di-2-ethylhexanoate. These humectants can be used individually or in appropriate combinations of two or more.

[0027] Examples of hydrotropes include methyl alcohol, ethyl alcohol, butyl alcohol, propanol, propylene glycol, dipropylene glycol, ethylene glycol, diethylene glycol, polyethylene glycol, glycerin, diglycerin, and sugar alcohols. These hydrotropes can be used individually or in appropriate combinations of two or more.

[0028] Examples of deodorizing components include plant extracts such as rice, pine, cypress, bamboo grass, green tea, and sugarcane; quaternary ammonium salts such as alkylbenzyldimethylammonium salt and didecyldimethylammonium salt; heterocyclic compounds such as cetylpyridinium salt and benzoisothiazoline; silver compounds such as silver oxide, silver-containing water-soluble glass, silver-supported zeolite, silver nanoparticles, silver ions, silver nitrate, and silver sulfide; metal compounds such as zinc oxide, copper oxide, zinc ions, copper ions, and gold nanoparticles; inclusion compounds such as cyclodextrin and cyclophane; amphoteric compounds such as amphoteric surfactant-based deodorants and amino acid-based deodorants; silica gel, alumina, activated carbon, and zeolite. These deodorizing components can be used individually or in appropriate combinations of two or more.

[0029] Examples of pH adjusting agents include inorganic acids such as hydrochloric acid and phosphoric acid and their salts, organic acids such as lactic acid, malic acid, succinic acid, fumaric acid, tartaric acid, and gluconic acid and their salts, and alkaline substances such as sodium hydroxide, potassium hydroxide, ammonia, and triethanolamine. These pH adjusting agents can be used individually or in appropriate combinations of two or more. However, a composition comprising tannic acid, ethanol, and phosphoric acid instead of citric acid, with an ethanol content of 10% by mass or more and a pH of 4.0 to 4.6, showed little effect in suppressing browning over time.

[0030] Examples of preservatives and disinfectants include benzoates, parahydroxybenzoates, phenoxyethanol, salicylic acid, 1,2-dibromo-2,4-disyanobutane, photosensitizers, dehydroacetates, isothiazolone derivatives, hydantoin derivatives, ethyl alcohol, isopropanol, povidone-iodine, silver ions and their supply compounds, hinokitiol, triclosan, chlorhexidine gluconate, didecyldimethylammonium chloride, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, and polyhexamethylene biguanide. These preservatives and disinfectants can be used individually or in appropriate combinations of two or more.

[0031] Examples of UV absorbers include oxybenzone, ethyl diisopropylcinnamate, cinoxate, glyceryl dimethoxycinnamate ethylhexanoate, isopropyl paramethoxycinnamate, and octyl methoxycinnamate. These UV absorbers can be used individually or in appropriate combinations of two or more.

[0032] <Uses, methods of use, and dosage forms of the composition> The use of the composition is not particularly limited. For example, the composition may be a functional composition such as a deodorant containing functional ingredients such as deodorizing components. It may also be an anti-allergen composition having anti-allergic properties derived from tannic acid.

[0033] The method of use of the composition is not particularly limited. Methods of use include, for example, applying the composition to objects such as fibers and textile products by spraying, coating, or immersion. Examples of such objects include clothing, carpets, sofas, wallpaper, curtains and other interior furnishings, bedding such as futon covers, futon padding, sheets, pillowcases, and mats, automotive parts such as car seats, car mats, ceiling and floor materials, stuffed animals, cleaning wet wipes, masks, filter materials, and vacuum cleaner dust bags.

[0034] The dosage form of the composition is not particularly limited and can be appropriately selected according to its use and method of use. Examples of dosage forms of the composition include solid, liquid, gel, foam, and cream.

[0035] <Effects and Effects of the Embodiment> The operation of this embodiment will now be described. The composition comprises tannic acid, ethanol, and citric acid, with an ethanol content of 10% by mass or more, and a pH of 4.0 to 4.6.

[0036] According to the above configuration, the browning of compositions containing tannic acid as an active ingredient can be suppressed over a longer period of time. In addition, by including ethanol at a concentration of 10% by mass or more, antibacterial and disinfectant effects are more easily obtained. In this embodiment, "long-term" means four weeks or more.

[0037] Furthermore, the composition of this embodiment can omit the use of known browning inhibitors. Omitting the use of known browning inhibitors means that the amount of known browning inhibitors included is substantially 0% by mass. A substantially 0% by mass amount of known browning inhibitors means less than 0.01% by mass. Preferably, the amount of known browning inhibitors included is less than 0.005% by mass, and more preferably less than 0.003% by mass. The amount of known browning inhibitors included can be 0% by mass.

[0038] Known browning inhibitors include, for example, polyoxyethylene alkyl ether sulfates, phenoxyethanol, and isopropylmethylphenol. Specific examples of polyoxyethylene alkyl ether sulfates include those having 12 to 14 carbon atoms and an average number of ethylene oxide additions of 1.5 or more.

[0039] Next, the effects of this embodiment will be described. (1) The composition comprises tannic acid, ethanol, and citric acid, wherein the amount of ethanol is 10% by mass or more, and the pH is 4.0 or higher and 4.6 or lower.

[0040] According to the above configuration, the browning of compositions containing tannic acid as an active ingredient over time can be suppressed for a longer period of time. (2) It is preferable that the amount of citric acid in the composition is 0.09% by mass or less.

[0041] According to the above configuration, the browning of the composition over time can be suppressed more effectively and over a longer period of time. (3) Preferably the composition further contains a mite repellent component. The above configuration provides an effect that repels mites. [Examples]

[0042] The compositions of the present invention will be described in more detail based on the following test examples. However, the present invention is not limited to the configurations described in the Examples section. <Test Example 1> The compositions of Reference Examples 1 to 9 were prepared using the formulations shown in Table 1. The values ​​in the "Formulation" column of Table 1 are in mass%, and the compositions were prepared to be 100% by mass overall.

[0043] (Evaluation of browning inhibitory effect) The compositions of Reference Examples 1-9 were filled into plastic containers and left in a dark room at 55°C. Before and after 4 weeks and 8 weeks of storage, the color of each composition was measured using a spectrophotometer (SE7700, manufactured by Nippon Kogyo Co., Ltd.), and the color difference ΔE* of the composition before and after storage was determined. Note that Reference Examples 2-3 were not stored for 8 weeks.

[0044] Furthermore, the suppression of browning of the composition was evaluated based on the following evaluation criteria. The results are shown in the "Judgment" column of Table 1. • "Judgment" evaluation criteria ◎ (Good): The color difference ΔE* is 0 or greater and less than 0.8.

[0045] ○ (Acceptable): The color difference ΔE* is 0.8 or greater and less than 2.0. × (Not acceptable): The color difference ΔE* is 2.0 or greater.

[0046] [Table 1]

[0047] As shown in Table 1, Reference Examples 1 and 2 could not be evaluated for suppressing browning of the compositions. In contrast, Reference Examples 3 to 5 could be evaluated for suppressing browning of the compositions. These results suggest that if the amount of ethanol is 10% by mass or more, the browning over time of compositions containing tannic acid as an active ingredient can be suppressed.

[0048] On the other hand, the results from reference examples 7-9 suggest that a high amount of tannic acid may not provide sufficient browning inhibition. <Test Example 2> (Examples 1-11, Comparative Example 1) The compositions of Examples 1-11 and Comparative Example 1 were prepared using the formulations shown in Table 2. The values ​​in the "Formulation" column of Table 2 are in mass%, and the composition was prepared to be 100% by mass overall. Note that the amounts of the mite repellent components in Table 2 indicate the amounts of raw materials used.

[0049] The details of the ingredients used are listed below. Allergen-reducing substance: Allerbuster SSPA-B manufactured by Sekisui Chemical Co., Ltd. Sugarcane extract: MSX-201 manufactured by Mitsui Sugar Co., Ltd. Mite repellent ingredient: FRESCOLAT-50ET (50% pure content) manufactured by Symrise Co., Ltd. (Evaluation of browning inhibitory effect) In the same manner as in Test Example 1 described above, the color difference ΔE* of the compositions of Examples 1 to 11 and Comparative Example 1 was determined before and after 4 weeks and 8 weeks of standing. Note that for Comparative Example 1, clear browning was observed before and after 4 weeks of standing, so 8 weeks of standing was not performed.

[0050] Furthermore, the suppression of browning of the composition was evaluated based on the same evaluation criteria as in Test Example 1 above. The results are shown in the "Judgment" column of Table 2.

[0051] [Table 2]

[0052] As shown in Table 2, all of Examples 1 to 5 received an evaluation of "acceptable" or better regarding the suppression of browning of the compositions before and after 4 weeks and 8 weeks of standing. In other words, Examples 1 to 5 demonstrate that browning of compositions containing tannic acid as an active ingredient can be suppressed over a longer period of time. Furthermore, in Examples 6 to 9, even with relatively low amounts of ethanol (10.00% to 30.00% by mass), the evaluation of browning suppression of the compositions before and after 4 weeks and 8 weeks of standing was "acceptable" or better. In addition, in Examples 10 and 11, even with relatively high amounts of ethanol (70.00% by mass), the evaluation of browning suppression of the compositions before and after 4 weeks and 8 weeks of standing was "good." Examples 6 to 11 also demonstrate that browning of compositions containing tannic acid as an active ingredient can be suppressed over a longer period of time.

Claims

1. Tannic acid and, Ethanol and, It is made by combining citric acid, The amount of ethanol blended is 10% by mass or more, A composition characterized by having a pH of 4.0 or higher and 4.6 or lower.

2. The composition according to claim 1, characterized in that the amount of citric acid is 0.09% by mass or less.

3. The composition according to claim 1 or claim 2, further containing a mite repellent component.

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