Use of ABCG1 phosphorylation sites as tumor biomarkers

JP2026502296A5Pending Publication Date: 2026-06-03FUDAN UNIV SHANGHAI CANCER CENT
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
FUDAN UNIV SHANGHAI CANCER CENT
Filing Date
2024-01-09
Publication Date
2026-06-03

AI Technical Summary

Technical Problem

The specific phosphorylation sites of ABCG1 protein have not been conclusively identified, hindering their use in tumor risk assessment, diagnosis, and prognosis evaluation.

Method used

Identification and validation of ABCG1 phosphorylation sites, specifically Y97, T99, S120, S125, T272, S277, S441, and Y655, for use in reagents and antibodies to assess tumor development, diagnose tumors, and evaluate prognosis, as well as inhibiting these sites for tumor treatment.

Benefits of technology

The identified phosphorylation sites provide significant clinical significance in tumor risk assessment, diagnosis, and prognosis evaluation for various cancers, including ovarian, osteosarcoma, glioblastoma, lung, breast, cervical, esophageal, gastric, liver, pancreatic, bladder, and colon cancers.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure 00000000_0000_ABST
    Figure 00000000_0000_ABST
Patent Text Reader

Abstract

The present invention relates to the use of reagents and / or devices for detecting human ABCG1 phosphorylation sites and kits for use in preparing reagents for tumor risk assessment, tumor diagnosis, or tumor prognosis evaluation, and to the use of reagents and kits for inhibiting human ABCG1 phosphorylation sites in preparing drugs for tumor prevention and / or treatment. The human ABCG1 phosphorylation sites are selected from one or more of Y97, T99, S120, S125, T272, S277, S441, and Y655. Phosphoantigen peptides and antibodies of the human ABCG1 protein, as well as uses and kits thereof, are also disclosed. The use of any one or more of the ABCG1 phosphorylation sites has important clinical significance in tumor risk assessment, diagnosis, treatment, and prognosis evaluation.
Need to check novelty before this filing date? Find Prior Art