Novel E3 ubiquitin ligase ligand, proteolytic agent, and its applications

Abstract

This disclosure relates to compounds of formula (I) and formula (II) or salts thereof, enantiomers, stereoisomers, solvates, isotopic enriched analogs, pharmaceutical precursors or polymorphs, and applications thereof. This disclosure further relates to drug compositions comprising a compound of formula (I) or salts thereof, enantiomers, stereoisomers, solvates, isotopic enriched analogs, pharmaceutical precursors or polymorphs as an active ingredient, and applications thereof. JPEG2026510375000780.jpg43165

Description

[Technical Field]

[0001] This disclosure relates to a proteolytic compound of formula (I), a cereblon (CRBN) E3 ubiquitin ligase ligand compound of formula (II), and its applications. The proteolytic compound of formula (I) can efficiently treat or prevent diseases or conditions associated with the degradation of proteins. The CRBN E3 ubiquitin ligase ligand compound of formula (II) can be conjugated to CRBN E3 ligase and used in the production of the proteolytic compound of formula (I). PBM-LIN-ULM formula (I) [ka] Formula (II) [Background technology]

[0002] A bifunctional proteolytic target drug consists of three parts: one end is a ligand warhead capable of binding to a specific target protein, and the other end is a small molecule ligand for E3 ubiquitin ligase. These two parts are linked by a linker unit of different lengths and types in the middle. The bifunctional proteolytic small molecule compound, through the binding action of the ligands at both ends, simultaneously binds to a specific target protein and E3 ubiquitin ligase, thereby recruiting the E3 ubiquitin ligase to the vicinity of the specific target protein, allowing the E3 ubiquitin ligase to ubiquitize the target protein. The polyubiquitinated target protein is then recognized and degraded by proteases in the body. The biggest difference between proteolytic target drugs and conventional small molecule inhibitors is that they mobilize the entire cell as a drug-effect unit. This drug action model allows small molecule drugs to temporarily bind to target proteins, essentially "tagging" the target protein to indicate that it needs to be degraded. This enables the requirement to be met with low drug concentrations, significantly reducing the risk of detargeting effects, and fundamentally eliminating tumor progression due to abnormal expression of driver genes and drug resistance caused by acquired mutations in driver genes.

[0003] E3 ubiquitin ligases, which are involved in the design of proteolytic drugs, include over 600 different proteins. Currently, only a few ligases have been successfully applied to the study of proteolytic agents, and Cereblon (CRBN) E3 ubiquitin ligase is one of the most widely used E3 ubiquitin ligases among them. Currently known CRBN-type E3 ubiquitin ligase ligands (CRBN ligands) include thalidomide and its analogs pomalidomide and lenalidomide, all of which have a phthalimide skeleton. Currently in the clinical stage, ARV-110 targeting AR, ARV-471 targeting ER, NX-2127 targeting BTK, and FHD-609 targeting BRD9 are all bifunctional proteolytic agents designed using immunomodulatory imide drug (IMiD) CRBN ligands containing a phthalimide skeleton. However, these ligands have problems such as low solubility and weak CRBN binding affinity. Therefore, there is an urgent need to develop a series of novel CRBN ligands with high CRBN binding affinity and drug-like properties, and to utilize them in the design and synthesis of bifunctional proteolytic agents appropriate for different targets, thereby treating and / or preventing diseases or symptoms mediated by or associated with target proteins.

[0004] Furthermore, the imiz-type CRBN E3 ubiquitin ligase ligand, after binding to CRBN, itself acts as a molecular glue, inducing CRBN to recognize and ubiquitinize new substrate proteins, thereby inducing protein degradation and resulting in pharmacological effects including antitumor and immunomodulation. Molecular glue degraders directly target, degrade, and remove target proteins, offering the potential advantage of targeting "undruggable" targets. Moreover, molecular glue degraders generally have small molecular weights and excellent drug-like properties, making the research and development of such drugs highly valued. In addition to already marketed imids-type drugs, a further series of molecular glue compounds based on CRBN E3 ubiquitin ligase have been developed, such as Bristol-Myers Squibb's (BMS) CC-122, CC-220, CC-90009, CC-99282, and CC-92480, Novartis' DKY709, and C4 Therapeutics' CFT7455, all currently in clinical trials. The degradation substrates of these molecular glues have expanded from the initially discovered transcription factor IKZF1 / 3 to casein kinase 1α (CK1α), zinc finger protein 91 (ZFP91), and translation factor GSPT1, among others. Through the degradation of these protein substrates, molecular glues exert pharmacodynamic activities such as immunomodulation, anti-inflammatory, and antitumor activity in different indications.

[0005] As described above, CRBN ligands can be used not only as part of a bifunctional proteolytic agent to efficiently degrade specific pathogenic proteins, but also as molecular glue degraders themselves, inducing the degradation of different substrate proteins. Therefore, the focus of research in this field is to develop more novel CRBN ligands with diverse scaffold designs and drug-like properties, and to apply them to the development of bifunctional proteolytic agents. [Overview of the Initiative]

[0006] In view of the above, the present disclosure aims to provide small molecule ligands of novel E3 ubiquitin ligases, bifunctional proteolytic agents designed based on small molecule ligands of novel E3 ubiquitin ligases and various target protein ligands, their uses, and methods of using them. The E3 ligands provided herein have stronger CRBN binding ability and drug-like properties, and themselves have stronger activity in inducing the degradation of substrate proteins as molecular groups, and / or better selectivity; based on the E3 ligands provided herein, the bifunctional degraders designed for different targets have stronger degradation / inhibition effects on various different types or families of pathogenic proteins and good pharmacokinetic properties, thereby exhibiting broad pharmacological activities.

[0007] To achieve the above object and other related objects, in one aspect, the present disclosure provides a novel CRBN E3 ubiquitin ligase ligand that binds to the CRBN E3 ligase as a molecular group. The novel E3 ubiquitin ligase ligand of the present disclosure has CRBN binding ability and antitumor activity, and can further be applied to bifunctional degrading small molecules.

[0008] In some embodiments, the novel E3 ubiquitin ligase ligand of the present disclosure may be a compound of formula (II) or a salt, stereoisomer (including enantiomer), solvate, isotope-enriched analogue, prodrug or polymorph thereof.

Chemical formula

[0009] In another aspect, the proteolytic molecules designed based on the novel E3 ubiquitin ligase ligands and various target protein ligands of this disclosure may be compounds of formula (I) or salts thereof, stereoisomers (including enantiomers), solvates, isotopic enriched analogs, pharmaceutical precursors or polymorphs. PBM-LIN-ULM Equation (I) In the formula, PBM represents a target region that can bind to a protein, and PBM is covalently bound to ULM via the base LIN; ULM represents the ligand moiety capable of binding to E3 ubiquitin ligase and has the following structure (ULM): [ka] Formula (ULM) This represents, and in the formula, A represents N or CH; R a1 , R a2 , R a3 and R a4 They are the same or different, and each is independently hydrogen, deuterium, halogen, and C 1-6Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkoxy; Ring W 1 represents arylene or heteroarylene, and the ring W 1 There are arbitrarily m R a5 Replaced by each R a5 These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, nitro, amino, cyano, and C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, deuterated C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 2-6 Alkenyl, or C 2-6 Represents Alkinnil; m represents an integer of 0, 1, 2, 3, or 4; X is a combination, or -R b1 -N(R a6 )-R b2 - represents, where R a6 is hydrogen or C 1-6 Represents alkyl, and R b1 and R b2 Each of these is independently and arbitrarily substituted C 0-2 Represents alkylene; LIN is the linker portion, consisting of a bond, optionally substituted methylene, or optionally substituted linear or branched C 2-15 This represents alkylene, where the C of the straight-chain or branched chain is represented. 2-15 One or more pairs of adjacent carbon atoms in the alkylene carbon backbone are R a , R b The chain is arbitrarily interrupted by one or more groups selected from the group consisting of any combination thereof, and each group R a These are O, C(O), OC(O), S, S(O), S(O)2, and S(O)2N(R) respectively, independently of each other. a7 ), N(R a7)S(O)2, C(O)N(R a7 )、N(R a7 )C(O)、N(R a7 )及びN(R a7 )C(O)N(R a7 ) selected from the group consisting of, where each R a7 is independently H or C 1-3 represents alkyl, and when two or more groups R 2-30 are interposed in the carbon backbone skeleton of the linear or branched C a alkylene, each group R a are not directly connected to each other; each group R b is independently selected from the group consisting of optionally substituted cycloalkylene, optionally substituted arylene, optionally substituted heterocyclylene, optionally substituted heteroarylene, alkynylene, alkenylene, and any combination thereof.

[0010] In another aspect, the present disclosure provides a pharmaceutical composition comprising a compound of formula (I) or a salt thereof, stereoisomers (including enantiomers), solvates, isotope-enriched analogs, prodrugs or polymorphs, and at least one pharmaceutically acceptable carrier.

[0011] <00​​​​​​​​In another aspect, compounds of formula (I) provided herein or their salts, stereoisomers (including enantiomers), solvates, isotopic enriched analogs, pharmaceutical precursors or polymorphs, or drug compositions containing them as active ingredients, may be used to treat and / or prevent diseases or conditions selected from the group consisting of tumors, infectious diseases, autoinflammatory diseases, inflammatory diseases, autoimmune diseases, neurological diseases, respiratory diseases, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcomatoid diseases, adult respiratory distress syndrome, Onwell-Richter syndrome, Richter syndrome (RS), acute liver failure, diabetes mellitus, Kennedy disease, seborrheic alopecia, hirsutism, skin diseases, cardiovascular diseases, functional uterine bleeding, anemia, childhood anemia with regenerative disorders, endometriosis, transplant rejection, polycystic ovary syndrome, or thyroid diseases.

[0014] In another aspect, the Disclosure further provides a method for treating or preventing a disease or condition in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound of formula (I) or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor or polymorph, or a drug composition containing the same, wherein the disease or condition includes tumors, infectious diseases, autoinflammatory diseases, inflammatory diseases, autoimmune diseases, neurological diseases, respiratory diseases, anemia, hemorrhagic shock, transplant rejection, multiple organ dysfunction syndrome (MODS), sarcomatoids, adult respiratory distress syndrome, Unverricht syndrome, Richter syndrome (RS), acute liver failure, diabetes mellitus, Kennedy disease, seborrheic alopecia, hirsutism, skin diseases, cardiovascular diseases, functional uterine bleeding, anemia, childhood anemia with regenerative disorders, endometriosis, transplant rejection, polycystic ovary syndrome, and thyroid diseases.

[0015] In another aspect, the present disclosure provides applications for compounds of formula (II) or salts thereof, stereoisomers (including enantiomers), solvates, isotopic enriched analogs, pharmaceutical precursors or polymorphs in the production of cereblon protein (CRBN) binders.

[0016] In another aspect, the Disclosure provides uses for the compound of formula (II) or its salts, stereoisomers (including enantiomers), solvates, isotopic enriched analogs, pharmaceutical precursors, or polymorphs in the production of the compound of formula (I) or its salts, enantiomers, stereoisomers, solvates, isotopic enriched analogs, pharmaceutical precursors, or polymorphs.

[0017] In another aspect, the Disclosure further provides a method for producing a compound of formula (I) or a salt thereof, an enantiomer (including a mirror image isomer), a solvate, an isotopic enrichment analogue, a pharmaceutical precursor, or a polymorph of the compound of formula (II) or a salt thereof, a mirror image isomer, a stereoisomer, a solvate, an isotopic enrichment analogue, a pharmaceutical precursor, or a polymorph of the compound of formula (I) of the Disclosure.

[0018] In another aspect, the compounds of formula (II) provided herein, or salts thereof, stereoisomers (including enantiomers), solvates, isotopic enriched analogs, pharmaceutical precursors or polymorphs thereof, or drug compositions containing them as active ingredients, can be used as drugs for the treatment and / or prevention of diseases or conditions related to the cereblon protein.

[0019] In another aspect, the present disclosure provides a method for treating or preventing a disease or condition related to the cereblon protein in a subject, comprising administering to the subject a therapeutically effective amount of a compound of formula (II) or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analogue, pharmaceutical precursor or polymorph, or a drug composition containing said therein. [Brief explanation of the drawing]

[0020] [Figure 1] The results of Western Blot experiments on the compounds of the present invention that degrade target substrate proteins in cells are shown. [Modes for carrying out the invention]

[0021] To help those skilled in the art understand and implement the contents of this disclosure, the following detailed descriptions are provided as exemplary specific embodiments. However, such descriptions are not intended to limit the scope of this disclosure, and it should be recognized that, provided that they do not deviate from the spirit and scope of this disclosure, the specific embodiments described herein can be further modified and altered in various ways, and such modifications and improvements will fall within the scope of protection of this disclosure. I. Compound Compound of formula (I)

[0022] Compounds of formula (I) or their salts (including pharmaceutically acceptable salts), stereoisomers (including enantiomers), solvates, isotopic enriched analogs, pharmaceutical precursors, or polymorphs of the present disclosure can bind to target proteins and recruit them to E3 ubiquitin ligases for ubiquitination tagging and degradation. Compounds of formula (I) of the present disclosure specifically target certain types or families of target proteins and exhibit broad pharmacological activity through degradation / inhibition of various different types or families of target proteins. PBM-LIN-ULM Equation (I) In the formula, PBM, LIN, and ULM are defined as in the compound of formula (I) above.

[0023] In some embodiments, the PBM may be a small molecule ligand that binds to a specific target protein, such as epidermal growth factor receptor (EGFR), cyclin-dependent kinase 4 / 6 (CDK4 / 6), cyclin-dependent kinase 2 (CDK2), anaplastic lymphoma kinase (ALK), activin receptor-like kinase 2 (ALK2), fibroblast growth factor receptors (FGFRs), proto-oncogene tyrosine-protein kinase receptor (RET), focal adhesion kinase (FAK), or breakpoint cluster region (BCR)-Abelson leukemia virus. virus (ABL) (BCR-ABL) tyrosine kinase, Bruton tyrosine kinase (BTK), androgen receptor (AR), estrogen receptor (ER), bromodomain and extra-terminal domain protein (BET), interleukin-1 receptor-associated kinase 4 (IRAK4), cyclin-dependent kinase 9 (CDK9), histone-lysine N-methyltransferase EZH2 (EZH2), neurotrophic receptor tyrosine kinasekinase (NTRK), Src homology 2 domain containing protein tyrosine phosphatase (SHP2), poly(ADP-ribose) polymerase (PARP), signal transducers and activators of transcription 3 (STAT3), FMS-like tyrosine kinase 3 (FLT3), BCL-2 (B cell lymphoma-2) family proteins, SOS Ras / Rac guanine nucleotide exchange factor 1 (SOS1) or GTPase Kras (KRAS), SWI / SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 2 / 4 This includes, but is not limited to, member 2 / 4 (SMARCA2 / 4) and ribosomal protein S6 kinase (RSK).

[0024] In some embodiments, PBM is given by the following formula: [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] It includes a structure selected from the group consisting of; During the ceremony, (R) in equation (PBM-1) 1a ) p1a The benzene ring connected to it has p1a R 1a This indicates that it is replaced by each R 1a They are the same or different, and each is independently deuterium, halogen, hydroxyl, NH2, NO2, cyano, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 Represents alkoxy; p1a represents an integer of 1, 2, 3, 4, or 5; R 1b is a combination, or C 1-3 alkyl, deuterated C 1-3 Alkyl, halogenated C 1-3 C optionally substituted with substituents selected from the group consisting of alkyls and halogens 1-2Represents alkylene; (R 1c ) p1b In formula (PBM-1), the quinazoline ring has p1b R 1c This indicates that it is replaced by each R 1c These are the same or different, and each is independent of deuterium, halogen, NO2, cyano, and halogen C. 1-6 Alkyl, C 1-10 alkyl, deuterated C 1-10 Alkyl, C 1-10 Alkoxy, C halogenated 1-10 Alkoxy, -O-optionally substituted heterocyclyl, or -NHC(O)R 1e This represents R 1e is C 1-10 alkyl, deuterated C 1-10 Alkyl or C 2-10 Represents an alkenil, for example R 1c is methyl, methoxy, [ka] or [ka] ,for example [ka] It represents; p1b represents an integer of 1, 2, or 3; R 1d is hydrogen, deuterium or C 1-3 Represents alkyl; (R) in equation (PBM-2) 2a ) p2a The benzene ring connected to it has p2a R 2a This indicates that it is replaced by each R 2a These are the same or different, and each is independently of deuterium, halogen, nitro, cyano, and halogen C. 1-6 Alkyl, C 1-10 alkyl, deuterated C 1-10 Alkyl, C 1-10 Alkoxy or -NHC(O)R 2d This represents R2d is C 1-10 alkyl, deuterated C 1-10 Alkyl or C 2-10 Represents an alkenil, for example R 2a is methyl, methoxy, nitro or [ka] It represents; p2a represents an integer of 1, 2, 3, or 4; (R 2b ) p2b In formula (PBM-2), the 1H-indole ring has p2b R 2b This indicates that it is replaced by p2b, where p2b represents an integer of 0, 1, 2, or 3, and each R 2b They are the same or different, and each is independent of deuterium and deuterated C. 1-10 Alkyl, C 1-10 Alkyl, halogen, or halogenated C 1-10 Represents alkyl; R 2c is hydrogen, C 1-10 alkyl, deuterated C 1-10 Alkyl, halogen, or halogenated C 1-10 Represents alkyl; (R) in equation (PBM-3) 3a ) p3a The benzene ring connected to it has p3a R 3a This indicates that it is replaced by each R 3a They are the same or different, and each is independently deuterium, halogen, hydroxyl, C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Represents alkoxy, NO2, NH2, or cyano; p3a represents an integer of 0, 1, 2, 3, 4, or 5; R 3b C is either substituted or unsubstituted. 3-15 Represents cycloalkyl groups, such as cyclopentyl; R in equation (PBM-4) 4a C 6-10Represents an aryl or a 5-20 member heteroaryl, and the C 6-10 Each aryl or 5-20 membered heteroaryl can be independently and optionally substituted with a substituent, which can independently be deuterium, halogen, hydroxyl, cyano, amino, nitro, or C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 One or more (e.g., 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) selected from the group consisting of alkoxys or any combination thereof; R 4b C 6-10 This represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl containing one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), where C 6-10 The aryl and the 5-20 membered heteroaryl each independently have one or more (e.g., 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) R 4d Replaced by, and each R 4d They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It is an alkoxy; (R 4c ) p4a In formula (PBM-4), the isoindoline ring has any p4a R 4c This indicates that it is replaced by each R 4c They are the same or different, and each is independently deuterium, halogen, hydroxyl, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, NO2, NH2, C 1-6 Alkoxy, C halogenated 1-6Represents alkoxy or cyano; p4a represents an integer of 0, 1, 2, or 3; R in equation (PBM-5) 5a is hydrogen, C 1-10 Alkyl (for example, [ka] ), deuterated C 1-10 Alkyl or halogenated C 1-10 Represents alkyl; R 5b teeth, [ka] Alternatively, it represents a 4-12 member nitrogen-containing heterocycline, where each of the 4-12 member nitrogen-containing heterocyclines is independently a deuterium, halogen, hydroxyl, or C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Optionally substituted with one or more substituents (e.g., 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) selected from the group consisting of alkoxy, NO2, NH2, cyano, or any combination thereof; In equation (PBM-6), ring A is C 6-10 The term represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl containing one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), wherein ring A has one or more (for example, 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) R 6a It is arbitrarily replaced by and each R 6a They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated1-6 Alkoxy, C 2-6 Alkenyl, or C 2-6 It is alkinyl; In equation (PBM-6), ring B is C 3-15 R represents a cycloalkyl or 4-20 membered heterocycline (for example, a heterocycline containing 1-4 heteroatoms selected from the group consisting of N, O, and S), where ring B is one or more (for example, 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) R 6b It is arbitrarily replaced by and each R 6b They are the same or different, and each is independently deuterium, halogen, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It is an alkoxy; In formula (PBM-6), ring C represents a 5-20 membered heteroaryl (for example, a 5-20 membered monocyclic or bicyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S), and ring C may have one or more (for example, 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) R atoms. 6c Replaced by, and each R 6c They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It is an alkoxy; R in equation (PBM-7) 7a R represents a 4-20 membered heterocycline (for example, a heterocycline containing 1-4 heteroatoms selected from the group consisting of N, O, and S), where the 4-20 membered heterocycline can have any one or more (for example, 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) R 7c Replaced by, and each R 7cThey are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It is an alkoxy; (R) in equation (PBM-7) 7b ) p7a The benzene ring connected to it has p7a R 7b This indicates that it is replaced by each R 7b They are the same or different, and each is independently deuterium, halogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6 It represents an alkyl group, and p7a represents an integer of 1, 2, 3, or 4; In formula (PBM-8), X1 is N or CR. 8f This represents R 8f represents hydrogen, deuterium, or amino, and X2 is N or CR. 8g This represents R 8g represents hydrogen or a bond, and X3 represents CH or N; R 8a and R 8b Each of these independently represents either a hydrogen atom or a bond; (R) in equation (PBM-8) 8c ) p8a The benzene ring connected to it has p8a R 8c This indicates that it is replaced by each R 8c These are the same or different, and each is independently -O-aryl, -O-heteroaryl, 4-20 membered heterocyclyl, and -C 1-3 Alkylene-NHC(O)-heteroaryl, -C 1-3 Alkylene-C(O)NH-heteroaryl, C 1-6 alkyl, deuterium, deuterated C 1-6 Alkyl, halogen, or halogenated C 1-6Representing alkyl, the 4-20 membered heterocyclyl, aryl, and heteroaryl each independently have one or more (e.g., 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) R 8h Replaced by, and each R 8h They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It is an alkoxy; p8a represents an integer of 1, 2, 3, or 4; R 8d is a bond, hydrogen, halogen, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkoxy, or C 1-6 Represents alkoxy; R 8e Hydrogen, halogen, cyano, C 1-6 Alkyl, halogenated C 1-6 Represents alkyl or amino; Here R 8g , R 8a , R 8b and R 8d It is not hydrogen at the same time, and R 8g , R 8a , R 8b and R 8d Only one of them represents a combination, and here, R 8a When R represents a combination, 8a The ring-forming carbon atoms connected are directly R c It is connected to, and X2 represents CH or N, and R 8b is hydrogen, and R 8d It is not a combination; X2 is CR 8g This represents R 8g When R represents a combination, 8g The ring-forming carbon atoms connected are directly R c It is connected to R8a and R 8b Both are hydrogen, and R 8d It is not a combination; R 8b When R represents a combination, 8b The ring constituent nitrogen atoms connected are directly R c It is connected to, and X2 represents N or CH, and R 8a is hydrogen, and R 8d is not a combination; and R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to and X2 represents N or CH, and R 8a and R 8b Both are hydrogen; In formula (PBM-9), X4 is CR 9e or fragment [ka] This represents the connection point between X4 and adjacent N, where the sign # represents the connection point with X5, and each R 9e These are independently deuterium, hydrogen, halogen, and C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, -C(O)-C 1-6 Alkyl, -C(O)-deuterated C 1-6 Alkyl or -C(O)NR 9f R 9g This represents R 9f , R 9g They are the same or different, and each is independent of hydrogen, C 1-6 Alkyl or deuterated C 1-6 Represents alkyl; In formula (PBM-9), X5 is N or CR. 9h This represents R 9h is hydrogen, deuterium, halogen, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; X6 and X7 each independently represent CH or N; R 9a represents a bonded or optionally substituted heteroarylene (e.g., a heteroarylene substituted with a halogen or deuterium); R 9b is hydrogen, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl or optionally substituted C 3-12 Represents a cycloalkyl group; (R) in equation (PBM-9) 9c ) p9a The pyridine ring connected to it has an arbitrary number of p9a R 9c This indicates that it is replaced by each R 9c They are the same or different, and each is independently deuterium, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 It represents an alkyl group, and p9a represents an integer of 0, 1, 2, or 3; (R) in equation (PBM-9) 9d ) p9b The bicyclic nitrogen-containing heteroaromatic ring connected to it has any p9b R 9d This indicates that it is replaced by each R 9d They are the same or different, and each is independently deuterium, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 The character represents an alkyl group, and p9b represents an integer of 0 or 1; (R) in equation (PBM-10) 10a ) p10a The benzene ring connected to it has any p10a R 10a This indicates that it is replaced by each R 10a They are the same or different, and each is independently deuterium, cyano, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6Alkoxy, C halogenated 1-6 Alkyl or deuterated C 1-6 Represents alkyl, where p10a represents an integer of 0, 1, 2, or 3; (R 10b ) p10b The benzene ring connected to it is arbitrarily p10b R 10b This indicates that it is replaced by each R 10b They are the same or different, and each is independently deuterium, cyano, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C halogenated 1-6 Alkyl or deuterated C 1-6 It represents an alkyl group, and p10b represents an integer of 0, 1, 2, 3, or 4; Each R 10c and R 10d They are the same or different, and each is independent of deuterium, C 1-6 Alkyl, halogen, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It is an alkoxy; In equation (PBM-11), (R 11a ) p11a The benzene ring connected to it has p11a R 11a This indicates that it is replaced by each R 11a They are the same or different, and each is independently deuterium, halogen, hydroxyl, amino, cyano, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C halogenated 1-6 Alkyl or deuterated C 1-6 Represents alkyl; p11a represents an integer of 1, 2, 3, 4, or 5; R 11b is NR 11d R 11e This represents R 11d , R 11e They are the same or different, and each is independent of hydrogen, C 1-6 Alkyl, halogenated C1-6 Alkyl or deuterated C 1-6 Represents alkyl; R 11c Deuterium, hydrogen, halogen, hydroxyl, amino, cyano, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C halogenated 1-6 Alkyl or deuterated C 1-6 Represents alkyl; X8, X9, X in equation (PBM-12) 10 , X 11 and X 12 They are the same or different, and each independently represents N or CH; R 12a represents a bonded or optionally substituted methylene (e.g., a halogen-substituted methylene); R 12b is -C(O)N(R 12f )R 12e , -N(R 12f )C(O)R 12e -S(O)2N(R 12f )R 12e , -N(R 12f )S(O)2R 12e -S(O)2R 12e or -P(O)(R 12e ) represents 2, where each R 12e They are the same or different, and each is independent of C 1-6 Alkyl or deuterated C 1-6 Represents alkyl, R 12f is hydrogen or C 1-6 Represents alkyl; In equation (PBM-12), (R 12c ) p12a It is connected to X9 and X 10 A 6-membered ring containing any p12a R 12c This indicates that it is replaced by each R 12c They are the same or different, and each is independently deuterium, halogen, hydroxyl, amino, cyano, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C1-6 Alkyl or halogenated C 1-6 Represents alkyl; p12a represents an integer of 0, 1, 2, 3, or 4; R 12d These are deuterium, halogen, hydroxyl, amino, cyano, and C. 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; Each (R) in equation (PBM-13) 13a ) p13a Each of these independently has a benzene ring connected to it with any p13a R 13a This indicates that it is replaced by each R 13a They are the same or different, and each is independently deuterium, halogen, hydroxyl, amino, cyano, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; Each p13a is either the same or different, and each independently represents an integer of 0, 1, 2, 3, or 4; (R) in equation (PBM-14) 14a ) p14a The benzene ring connected to it has p14a R 14a This indicates that it is replaced by p14a, where p14a represents an integer of 0, 1, 2, 3, 4, or 5, and each R 14a They are the same or different, and each is independently deuterium, halogen, hydroxyl, amino, cyano, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; Each R 14b These are the same or different, and each independently of the others, halogen, hydroxy, amino, cyano, and C 1-6 Alkoxy, C halogenated 1-6Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; (R) in equation (PBM-15) 15a ) p15a The benzene ring connected to it has any p15a R 15a This indicates that it is replaced by each R 15a They are the same or different, and each is independently deuterium, halogen, hydroxyl, amino, cyano, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p15a represents an integer of 0, 1, 2, 3, or 4; (R 15b ) p15b The 4-oxo-3,4-dihydroquinazoline ring connected to it has p15b R 15b This indicates that it is replaced by each R 15b These are the same or different, and each independently of the others, halogen, hydroxy, amino, cyano, and C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p15b represents an integer of 1, 2, 3, or 4; R in equation (PBM-16) 16a C 6-10 Represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl containing one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), and the C 6-10 Each aryl or 5-20 membered heteroaryl is independently and arbitrarily associated with one or more (e.g., 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) R 16d Replaced by, and each R 16dThey are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 2-6 Alkenyl, or C 2-6 It is alkinyl; In equation (PBM-16), (R 16b ) p16a The 1,2,3,4-tetrahydroquinoline rings connected to it are p16a R 16b This indicates that it is replaced by each R 16b They are the same or different, and each is independently deuterium, halogen, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p16a represents an integer of 0, 1, 2, 3, or 4; In equation (PBM-16), (R 16c ) p16b The benzene ring connected to it has p16b R 16c This indicates that it is replaced by each R 16c They are the same or different, and each is independently deuterium, halogen, hydroxyl, amino, cyano, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p16b represents an integer of 0, 1, 2, 3, or 4; In equation (PBM-17), (R 17a ) p17a The benzene ring connected to it has p17a R 17a This indicates that it is replaced by each R 17a They are the same or different, and each is independently deuterium, halogen, hydroxyl, amino, cyano, C 1-6Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p17a represents an integer of 1, 2, 3, 4, or 5; R 17b is halogen, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; (R) in equation (PBM-18) 18a ) p18a The quinoline ring connected to it has p18a R 18a This indicates that it is replaced by each R 18a They are the same or different, and each is independently deuterium, halogen, hydroxyl, amino, cyano, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p18a represents an integer of 1, 2, 3, or 4; (R) in equation (PBM-18) 18b ) p18b The benzene ring connected to it has p18b R 18b This indicates that it is replaced by each R 18b They are the same or different, and each is independently deuterium, halogen, hydroxyl, amino, cyano, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p18b represents an integer of 1, 2, 3, 4, or 5; R in equation (PBM-19) 19a represents -NHC(O)- or -C(O)NH-; R 19b -NH-, -N(C 1-6 Represents alkyl)- or ethynylene; In formula (PBM-19), ring D represents a 5-20 member monocyclic, dicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S, and (R 19c ) p19a The ring D has an arbitrary number of p19a R 19c This indicates that it is replaced by and each R 19c These are the same or different, and each independently, optionally substituted 5-15 member heteroaryl, deuterium, halogen, hydroxyl, cyano, amino, and C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 Represents alkoxy; p19a represents an integer of 0, 1, 2, or 3; Each (R) in equation (PBM-19) 19d ) p19b Each of these independently has a benzene ring connected to it, each independently having an arbitrary number of p19b R 19d This indicates that it is replaced by each R 19d They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; Each p19b is either the same or different, and each independently represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-20) 20a , R 20b , R 20c and R 20d Each of these is independently bonded: hydrogen, deuterium, halogen, hydroxyl, cyano, amino, and C. 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl, where R 20a , R20b , R 20c and R 20d Only one of the elements represents a bond, while the other three are the same or different and each independently represents hydrogen, halogen, or hydroxyl, where R 20a , R 20b , R 20c and R 20d If one of the elements represents a bond, the benzene ring or methylene group connected to it in formula (PBM-20) is directly R c Connected; The sign that connects the double bond in equation (PBM-20) [ka] " represents possible couplings in spatial configuration (cis or trans, or E- or Z- configuration); Each (R) in equation (PBM-20) 20e ) p20a Each of these independently has a benzene ring connected to it, each independently and arbitrarily having p20a R 20e This indicates that it is replaced by each R 20e They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; Each p20a is either the same or different, and each independently represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-21) 21d represents O, S, or CH2; (R 21c ) p21a p21a R 21c Each R represents a substituent. 21c They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C1-6 Represents alkyl; p21a represents an integer of 0, 1, 2, 3, or 4; R 21a and R 21b Only one of the elements represents a bond, and the other is hydrogen, halogen, hydroxyl, cyano, amino, or C. 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl, where R 21a and R 21b If one of the terms represents a bond, then the carbon atom of the benzene ring connected to it in formula (PBM-21) is directly R cに Connected; In formula (PBM-22), ring E represents a 5-20 member monocyclic, dicyclic, or polycyclic heteroarylene containing 1-4 heteroatoms selected from the group consisting of N, O, and S; R 22b These are optionally substituted 5-15 member heteroaryls, optionally substituted 5-15 member heterocyclines, deuterium, halogens, hydroxyl, cyano, amino, and C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 Represents alkoxy; R 22a is hydrogen, halogen, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 Represents alkoxy; R in equation (PBM-23) 23a These are optionally substituted 5-15 member heterocyclyls, optionally substituted 5-15 member heteroaryls, deuterium, halogens, hydroxyl, cyano, amino, and C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6Alkyl or C halogenated 1-6 Represents alkoxy; R 23b This represents a 5-20 membered monocyclic, dicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S, wherein the heteroaryl is composed of deuterium, halogen, hydroxyl, cyano, amino, or C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Optionally substituted with one or more substituents (e.g., 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) selected from the group consisting of alkoxys or any combination thereof; (R 24a ) p24a In formula (PBM-24), the isoquinoline ring has an arbitrary number of p24a R 24a This indicates that it is replaced by each R 24a They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, -C(O)NH2, Deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p24a represents an integer of 0, 1, 2, 3, or 4; (R 24b ) p24b In formula (PBM-24), the pyrrolidone ring has an arbitrary number of p24b R 24b This indicates that it is replaced by each R 24b They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, -C(O)NH2, Deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p24b represents an integer of 0, 1, 2, 3, or 4; In equation (PBM-24), y represents an integer of 1, 2, or 3; R in equation (PBM-25) 25g is N or CR 25h This represents R 25h represents hydrogen or halogen, R 25i is N or CR 25j This represents R 25j represents hydrogen or halogen; R 25f -H(O)NH-, -NHC(O)-, -S(O)2NH-, or -NHS(O)2- represent bonds; (R 25a ) p25a R in equation (PBM-25) 25g and R 25i A 6-membered ring containing any p25a R 25a This indicates that it is replaced by each R 25a They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p25a represents an integer of 0, 1, or 2; R 25b is hydrogen, halogen, C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl or -C 1-3 Alkylene-C 3-6 Represents a cycloalkyl group; R 25c is hydrogen, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; or R 25b and R 25c These, together with the corresponding nitrogen and carbon atoms attached to them, form optionally substituted 5- to 7-membered nitrogen-containing heterorings; R 25d R represents hydrogen or a bond,25e represents hydrogen or a bond, where R 25d and R 25e It is not hydrogen at the same time, and R 25d and R 25e Only one of the two represents a bond, and the other represents hydrogen, where R 25d When R represents a combination, 25d The ring-forming carbon atoms connected are directly R c Connected to and R 25e When R represents a combination, 25e The ring-forming carbon atoms connected are directly R c Connected; R in equation (PBM-26) 26a is a bond, C 1-3 Alkylene or halogenated carbon 1-3 Represents alkylene; R 26b This is an optionally substituted halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl, optionally substituted C 3-6 Cycloalkyl or optionally substituted C 1-6 Alkyl (for example, C optionally substituted by an optionally substituted aryl) 1-6 Represents alkyl; (R 26c ) p26a In formula (PBM-26), the benzene ring has an arbitrary number of p26a R 26c This indicates that it is replaced by each R 26c They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p26a represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-27) 27a C 1-3Alkylene or halogenated carbon 1-3 Represents alkylene; R 27b Deuterium, C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl or optionally substituted C 3-6 Represents a cycloalkyl group; R 27c and R 27d Each of these independently represents either S or O; R in equation (PBM-28) 28a C 1-3 Alkylene or halogenated carbon 1-3 Represents alkylene; (R 28b ) p28a The pyrazolo[1,5-a]pyrimidine ring connected to it has an arbitrary number of p28a R 28b This indicates that it is replaced by each R 28b They are the same or different, and each is independently hydroxy, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p28a represents an integer of 0, 1, 2, or 3; R 28c and R 28d The two are the same or different, and each is independently of hydrogen, or optionally substituted C. 1-10 Alkyl or optionally substituted C 3-15 Represents a cycloalkyl group; (R 28e ) p28b The benzene ring connected to it is arbitrarily p28b R 28e This indicates that it is replaced by each R 28e They are the same or different, and each is independent of the others, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p28b represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-29) 29a is -S- or fragment [ka] This represents R 29a When -S- represents R in equation (PBM-29), 29a And heteroaryls containing a nitrogen atom are thiazolyls, and also R 29a fragment [ka] When representing R in equation (PBM-29), 29a And heteroaryls containing a nitrogen atom are pyridyls; R 29b represents N or CH; R 29c is hydrogen or optionally substituted C 1-10 Represents alkyl; R 29d is hydrogen, -C 1-3 Alkilen-represents a 4- to 10-membered heterocycline with any substitution, or a 4- to 10-membered heterocycline with any substitution; R 29e is hydroxy, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; R in equation (PBM-30) 30a represents O or S; R 30b represents N or CH; R 30c and R 30d They are the same or different, and each is independently hydroxy, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6Represents alkyl; (R 30e ) p30a The benzene ring connected to it has any p30a R 30e This indicates that it is replaced by each R 30e They are the same or different, and each independently, deuterium, hydroxyl, halogen, amino, cyano, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Represents alkyl, -S(O)2NH2, or -C(O)NH2; p30a represents an integer of 0, 1, 2, 3, 4, or 5; R in equation (PBM-31) 31a C(O)NH, NHC(O), (CH2) 1-2 C(O)NH, (CH2) 1-2 NHC(O), C(O)NH(CH2) 1-2 NHC(O)(CH2) 1-2 , represents S(O)2NH or NHS(O)2; R 31b is hydrogen, hydroxyl, halogen, cyano, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; R 31c is hydrogen, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; or R 31b and R 31c These, together with the carbon atoms, nitrogen atoms, and carbon atoms on the benzene ring connected to the nitrogen atom, respectively, form an optionally substituted 4-6 membered heteroaromatic ring or an optionally substituted 4-6 membered heteroring; R 31d is an arbitrarily substituted C 3-6 Cycloalkyl, C 1-6 alkyl, deuterated C 1-6Alkyl, halogenated C 1-6 Represents an alkyl or optionally substituted 4-20 membered heterocycline; (R 31e ) p31a The pyridine-2(1H)-one ring connected to it has p31a R 31e This indicates that it is replaced by each R 31e These are the same or different, and each is independently hydroxy, halogen, cyano, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p31a represents an integer of 0, 1, 2, or 3; In formula (PBM-31), ring F represents an arylene, or a 5-20 membered monocyclic or bicyclic heteroarylene containing 1-4 heteroatoms selected from the group consisting of N, O, and S; (R 31f ) p31b The ring F has any p31b R 31f This indicates that it is replaced by and each R 31f They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 Represents alkoxy; p31b represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-32) 32c is an arbitrarily substituted C 1-3 Represents alkylene; (R 32a ) p32a The benzene ring connected to it has p32a R 32a This indicates that it is replaced by each R 32a These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p32a represents an integer of 0, 1, 2, 3, 4, or 5; (R 32b ) p32b The 1H-indazole ring connected to it has 32b p-units. 32b This indicates that it is replaced by each R 32b These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p32b represents an integer of 0, 1, 2, 3, 4, or 5; R 32d This represents C(O)NH, NHC(O), S(O)2NH, or NHS(O)2; R 32e is NR 32f R 32g This represents R 32f , R 32g They are the same or different, and each is independent of hydrogen, C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl, optionally substituted C 3-6 Represents a cycloalkyl or optionally substituted 4- to 8-membered heterocycline; X in equation (PBM-33) 13 , X 14 and X 15 The same or different, and each independently represents CH or N, where X 13 , X 14 and X 15 It is not N at the same time, and X 13 , X 14 and X 15 The 6-membered ring containing a halogen, hydroxyl, cyano, amino, C may optionally be further added. 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C1-6 Alkyl, halogenated C 1-6 Substituted with one or two substituents selected from the group consisting of alkyl groups or any combination thereof; In formula (PBM-33), ring G represents pyrrole, imidazole, pyrazole, benzene ring, pyridine, pyrimidine, or pyrazine; (R 33a ) p33a The benzene ring connected to it has any p33a R 33a This indicates that it is replaced by each R 33a These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p33a represents an integer of 0, 1, 2, 3, 4, or 5; (R 33b ) p33b The pyrrolidine ring connected to it has an arbitrary number of p33b R 33b This indicates that it is replaced by each R 33b These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p33b represents an integer of 0, 1, 2, 3, 4, 5, or 6; R 33c and R 33d They are the same or different, and each independently, hydrogen, halogen, hydroxyl, amino, cyano, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; (R 33e ) p33crepresents that the connected ring G is arbitrarily replaced by p33c R 33e where each R 33e is the same or different and each independently represents hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p33c represents an integer of 0 or 1; X 16 , X 17 and X 18 ... each independently represents CH or N; R 34a represents a bond, S or NH; R 34b represents a bond, optionally substituted cycloalkyl or optionally substituted 4- to 15-member nitrogen-containing heterocyclyl; R 34c represents a bond, halogen, amino, hydroxy, cyano, C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, deuterated C 1-6 alkyl, halogenated C 1-6 alkyl, optionally substituted cycloalkyl or optionally substituted 4- to 15-member nitrogen-containing heterocyclyl; where R 34b and R 34c are not simultaneously a bond, and only one of R 34b and R 34c is a bond. When R 34b represents a bond, the ring-constituting carbon atom connected to R 34b is directly connected to R c , and when R 34c represents a bond, the ring-constituting carbon atom connected to R 34c is directly connected to R c ; (R 34d ) p34a represents that the 6-membered ring connected thereto is arbitrarily replaced by p34a R 34dThis indicates that it is replaced by each R 34d These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p34a represents an integer of 0, 1, 2, 3, or 4; (R 34e ) p34b The nitrogen-containing 6-membered heteroaromatic ring connected to it has any p34b R 34e This indicates that it is replaced by each R 34e These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p34b represents an integer of 0, 1, or 2; (R) in equation (PBM-35) 35a ) p35a The phthalazinone ring connected to it has an arbitrary number of p35a R 35a This indicates that it is replaced by each R 35a These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p35a represents an integer of 0, 1, 2, 3, or 4; R 35b is an arbitrarily substituted C 1-3 Represents alkylene; (R 35c ) p35b The benzene ring connected to it has any p35b R 35c This indicates that it is replaced by each R 35care the same or different and each independently represents hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p35b represents an integer of 0, 1, 2, 3 or 4; In formula (PBM-36), (R 36a ) p36a means that the 2H-indazole ring connected thereto is optionally substituted with p36a number of R 36a , each R 36a are the same or different and each independently represents hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p36a represents an integer of 0, 1, 2 or 3; (R 36b ) p36b means that the benzene ring connected thereto is optionally substituted with p36b number of R 36b , each R 36b are the same or different and each independently represents hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6 alkoxy, halogenated C 1-6 alkoxy, deuterated C 1-6 alkyl or halogenated C 1-6 alkyl; p36b represents an integer of 0, 1, 2, 3 or 4; In formula (PBM-37), (R 37a ) p37a means that the benzofuran ring connected thereto is optionally substituted with p37a number of R 37a , each R 37a are the same or different and each independently represents hydroxy, amino, cyano, halogen, C 1-6 alkyl, C 1-6Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p37a represents an integer of 0, 1, 2, or 3; (R 37b ) p37b The benzene ring connected to it has any p37b R 37b This indicates that it is replaced by each R 37b These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p37b represents an integer of 0, 1, 2, or 3; In equation (PBM-38), (R 38a ) p38a The benzene ring connected to it has any p38a R 38a This indicates that it is replaced by each R 38a These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p38a represents an integer of 0, 1, 2, 3, or 4; R 38b , R 38c , R 38d They are the same or different, and each independently, hydrogen, deuterium, hydroxyl, amino, cyano, halogen, C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; R in equation (PBM-39) 39a , R 39bThey are the same or different, and each is independent of hydrogen, halogen, and C. 1-3 Alkyl or halogenated C 1-3 Represents alkyl; R 39c is a bond, hydrogen, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; y1 represents an integer of 1, 2, or 3; R 39d The structure of the following expression: [ka] This represents, Here, R 39e (R represents a bond or hydrogen; 39f ) p39a The benzene ring connected to it has any p39a R 39f This indicates that it is replaced by each R 39f These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl, and p39a represents an integer of 0, 1, 2, 3 or 4; y2 represents an integer of 1, 2 or 3; or R 39d The structure of the following expression: [ka] This represents, Here (R 39g ) p39b Each of these independently has p39b R benzene rings connected to it. 39g This indicates that it is replaced by each R 39g These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6Alkyl or halogenated C 1-6 The integer p39b represents an alkyl group, and p39b represents an integer of 0, 1, 2, 3, 4, or 5; Here R 39c and R 39e It is not a bond at the same time, and R 39c and R 39e Only one of them represents a bond, and here R 39c When R represents a combination, 39c The ring constituent nitrogen atoms connected are directly R c Connected to and R 39e When R represents a combination, 39e The ring-forming carbon atoms connected are directly R c Connected; (R) in equation (PBM-40) 40a ) p40a The benzene ring connected to it has any p40a R 40a This indicates that it is replaced by each R 40a These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p40a represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-40) x3 represents a bond, or C(O); R in equation (PBM-41) 41a is hydrogen, C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl, optionally substituted C 3-15 Represents a cycloalkyl or optionally substituted 4- to 15-membered nitrogen-containing heterocycline; R 41b is hydrogen, C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl, optionally substituted C 3-15Cycloalkyl, optionally substituted 4-15 member nitrogen-containing heterocyclyl or NR 41e R 41f This represents R 41e , R 41f They are the same or different, and each is independent of hydrogen, C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Represents an alkyl or optionally substituted 4- to 15-membered heterocycline; R 41c represents N or CH; (R 41d ) p41a The benzene ring connected to it has any p41a R 41d This indicates that it is replaced by each R 41d These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p41a represents an integer of 0, 1, 2, 3, or 4; In equation (PBM-42), (R 42a ) p42a The benzene ring connected to it has any p42a R 42a This indicates that it is replaced by each R 42a These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p42a represents an integer of 0, 1, 2, 3, 4, or 5; R 42b O, S, C 1-3 Alkylene or halogenated carbon 1-3 Represents alkylene; (R 42c ) p42bThe benzene ring connected to it is arbitrarily p42b R 42c This indicates that it is replaced by each R 42c These are the same or different, and each is independently hydroxy, amino, cyano, halogen, and C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; p42b represents an integer of 0, 1, 2, 3, or 4; In formula (PBM-43), ring H is C 6-15 (R) represents arylene or 5-15 member monocyclic, bicyclic, or polycyclic heteroarylene. 43a ) p43a The ring H has any p43a R 43a This indicates that it is replaced by and each R 43a They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It is an alkoxy; p43a represents an integer of 0, 1, 2, 3, or 4; R 43b This represents a 5-20 membered monocyclic, dicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S, which are optionally substituted, and which are hydroxyl, amino, cyano, halogen, nitro, or C. 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, deuterated C 1-6 Alkyl or halogenated C 1-6 Optionally substituted with substituents selected from the group consisting of alkyl groups; R in equation (PBM-44) 44a , R 44b , R 44c Each of these independently represents CH or N; R 44d is -C(O)NHR44h ,-NHC(O)R 44h -S(O)2NHR 44h , -NHS(O)2R 44h -S(O)2R 44h or -P(O)(R 44h ) represents 2, where each R 44h They are the same or different, and each is independent of C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; (R 44e ) p44a This has 44a substituents R 44e This represents each R 44e These are the same or different, and each is independently a halogen, hydroxyl, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 Represents alkoxy; p44a represents an integer of 0, 1, 2, 3, or 4; (R 44f ) p44b It has p44b substituents R 44f This represents each R 44f These are the same or different, and each is independently a halogen, hydroxyl, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 Represents alkoxy; p44b represents an integer of 0, 1, or 2; (R 44g ) p44c The benzene ring connected to it is arbitrarily p44c R 44g This indicates that it is replaced by and each R 44g These are, independently, halogen, hydroxy, cyano, amino, nitro, and C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C1-6 Alkyl or C halogenated 1-6 Represents alkoxy; p44c represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-45) x1 represents a bond or C(O), or -C(O)NH-R x2 -C(O)-*** represents the sign R. c This represents the connection point with R x2 is an arbitrarily substituted C 3-15 Represents a cycloalkyl group; (R 45a ) p45a The 1H-pyrrolo[2,3-b]pyridine ring connected to it has an arbitrary number of p45a R 45a This indicates that it is replaced by and each R 45a These are independently cyano, halogen, hydroxy, amino, nitro, and C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It is an alkoxy, and p45a represents an integer of 0, 1, 2, 3, 4, or 5; (R 45b ) p45b The pyridine ring connected to it has an arbitrary number of p45b R 45b This indicates that it is replaced by and each R 45b These are independently cyano, halogen, hydroxy, nitro, and C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 Alkoxy or NR 45c R 45d And here R 45c , R 45d They are the same or different, and each is independent of hydrogen, C 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl, optionally substituted C 3-15p45b represents a cycloalkyl group or an optionally substituted 4- to 15-membered heterocycline, and p45b represents an integer of 0, 1, 2, or 3; R in equation (PBM-46) 46a This represents NHC(O), C(O)NH, NHS(O)2, or S(O)2NH; (R 46b ) p46a The benzene ring connected to it has any p46a R 46b This indicates that it is replaced by and each R 46b These are, independently, halogen, hydroxy, cyano, amino, nitro, and C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or halogenated C 1-6 It is an alkoxy, and p46a represents an integer of 0, 1, 2, 3, 4, or 5; (R 46c ) p46b The 1H-pyrazole ring connected to it has an arbitrary number of p46b R 46c This indicates that it is replaced by and each R 46c These are, independently, halogen, hydroxy, cyano, amino, nitro, and C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or halogenated C 1-6 It is an alkoxy, and p46b represents an integer of 0, 1, or 2; R in equation (PBM-47) 47a represents N or CH, and R 47b represents O, S, NH, CH2, CH(F), or C(F)2; R 47c represents a bonded or optionally substituted methylene (e.g., a halogen-substituted methylene); Ring I is C 6-15 (R represents an aryl, a 4-15 membered heterocyclyl, or a 5-15 membered heteroaryl, 47d ) p47a The ring I connected to it has any p47a R 47dThis indicates that it is replaced by and each R 47d They are the same or different, and each independently, a deuterium, halogen, hydroxyl, cyano, amino, nitro, oxo group, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It is an alkoxy, and p47a represents an integer of 0, 1, 2, 3, or 4; (R 47e ) p47b R is connected to it. 47a A 6-membered nitrogen-containing heteroaromatic ring containing any p47b R 47e This indicates that it is replaced by each R 47e Each of these is independently deuterium, halogen, hydroxyl, cyano, amino, nitro, and C. 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 It represents an alkyl group, and p47b represents an integer of 0, 1, or 2; (R 47f ) p47c The benzene ring connected to it has any p47c R 47f This indicates that it is replaced by each R 47f They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 It represents an alkyl group, and p47c represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-48) 48a , R 48b and R 48c Each of these independently represents either N or CH; (R 48d ) p48a The naphthyl connected to it has an arbitrary number of p48a R 48dThis indicates that it is replaced by each R 48d These are, independently, halogen, hydroxy, amino, mercapto, nitro, cyano, and C. 2-6 Alkinyl, C 2-6 Alkenil, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 It represents an alkyl group, and p48a represents an integer of 0, 1, 2, 3, 4, 5, 6, or 7; R 48e is an arbitrarily substituted C 3-15 Represents a cycloalkyl or optionally substituted 4- to 15-membered heterocycline containing 1-4 heteroatoms selected from the group consisting of N, O, and S; R 48f These are hydrogen, halogen, hydroxy, cyano, amino, mercapto, nitro, and C. 2-6 Alkinyl, C 2-6 Alkenil, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy, C 1-6 alkyl, deuterated C 1-6 Alkyl or halogenated C 1-6 Represents alkyl; R in equation (PBM-49) 49a represents N or CH; R 49b represents NHC(O), C(O)NH, NHS(O)2, or S(O)2NH; (R 49c ) p49a R connected to it 49a A 6-membered ring containing any p49a R 49c This indicates that it is replaced by each R 49c These are the same or different, and each is independently a halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6It represents an alkoxy, and p49a represents an integer of 0, 1, 2, 3, or 4; Ring J represents a 5-15 member heteroarylene, (R 49d ) p49b The ring J connected to it has any p49b R 49d This indicates that it is replaced by each R 49d These are the same or different, and each is independently a halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, hydroxysubstituted C 1-6 Alkyl, amino-substituted C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 alkoxy or optionally substituted C 3-15 It represents a cycloalkyl group, and p49b represents an integer of 0, 1, 2, or 3; In formula (PBM-50), (R 50a ) p50a The benzene ring connected to it has p50a R 50a This indicates that it is replaced by each R 50a These are the same or different, and each is independently a halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl-S(O)2, halogenated C 1-6 Alkyl-S(O)2, halogenated C 1-6 Alkyl-NHC(O), C halogenated 1-6 Alkyl-C(O)NH, C halogenated 1-6 Alkyl-NHS(O)2, halogenated C 1-6 Alkyl-S(O)2NH, C 1-6 Alkyl or C halogenated 1-6 It represents an alkoxy, and p50a represents an integer of 0, 1, 2, 3, or 4; R 50b is hydrogen, C 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C1-6 Represents alkyl; In equation (PBM-51), (R 51a ) p51a The benzene ring connected to it has p51a R 51a This indicates that it is replaced by each R 51a These are the same or different, and each is independently a halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 alkoxy, optionally substituted C 3-15 Represents a cycloalkyl or a 4- to 15-membered heterocycline containing 1-4 heteroatoms selected from the group consisting of optionally substituted N, O, and S, and p51a represents an integer of 0, 1, 2, 3, 4, or 5; (R 51b ) p51b The benzene ring connected to it has p51b R 51b This indicates that it is replaced by each R 51b These are the same or different, and each is independently a halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 alkoxy, optionally substituted C 3-15 Represents a cycloalkyl or a 4- to 15-membered heterocycline containing 1-4 heteroatoms selected from the group consisting of optionally substituted N, O, and S, and p51b represents an integer of 0, 1, 2, 3, or 4; (R 51c ) p51c The isoxazole ring connected to it has any p51c R 51c This indicates that it is replaced by each R 51c These are the same or different, and each is independently a halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C1-6 Alkyl, C 1-6 Alkyl or halogenated C 1-6 It represents an alkoxy, and p51c represents an integer of 0, 1, or 2; In equation (PBM-52), the dashed line indicates the presence of an arbitrary double bond; (R 52a ) p52a The 6-membered cycloalkyl group connected to it has an arbitrary number of p52a R 52a This indicates that it is replaced by each R 52a These are the same or different, and each independently, halogen, hydroxy, mercapto, cyano, amino, nitro, oxo group, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or halogenated C 1-6 It represents an alkoxy, and p52a represents an integer of 0, 1, 2, 3, 4, 5, 6, 7, or 8; (R 52b ) p52b The benzene ring connected to it is arbitrarily p52b R 52b This indicates that it is replaced by each R 52b These are the same or different, and each independently, deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or halogenated C 1-6 It represents an alkoxy, and p52b represents an integer of 0, 1, 2, 3, 4, or 5; (R 52c ) p52c The 6-membered cycloalkyl group connected to it has an arbitrary number of p52c R 52c This indicates that it is replaced by each R 52c They are the same or different, and each independently, a halogen, cyano, oxo group, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or halogenated C 1-6It represents an alkoxy, and p52c represents an integer of 0, 1, 2, 3, 4, 5, 6, 7, or 8; (R 52d ) p52d The benzene ring connected to it is arbitrarily p52d R 52d This indicates that it is replaced by each R 52d These are the same or different, and each is independently a halogen, hydroxyl, mercapto, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy or [ka] This represents a value where p52d represents an integer of 0, 1, or 2; (R 52e ) p52e The benzene ring connected to it has any p52e R 52e This indicates that it is replaced by each R 52e These are the same or different, and each is independently deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, -SO2CF3, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or halogenated C 1-6 It represents an alkoxy, and p52e represents an integer of 0, 1, 2, 3, or 4; R 52f Hydrogen, deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkoxy, C halogenated 1-6 Alkoxy or [ka] This represents , where y3 represents an integer of 1, 2, or 3; In equation (PBM-53), (R53a ) p53a p53a substituents R 53a This represents each R 53a These are the same or different, and each is independently a halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It represents an alkoxy, and p53a represents an integer of 0, 1, 2, 3, 4, or 5; (R 53b ) p53b The benzene ring connected to it has any p53b R 53b This indicates that it is replaced by each R 53b These are the same or different, and each independently, deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or halogenated C 1-6 Represents an alkoxy, and p53b represents an integer of 0, 1, 2, 3, or 4; and R 53c is C 1-6 Alkylene or halogenated carbon 1-6 Represents alkylene; In equation (PBM-54), (R 54a ) p54a p54a substituents R 54a This represents each R 54a These are the same or different, and each is independently a halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It represents an alkoxy, and p54a represents an integer of 0, 1, 2, 3, or 4; (R 54b ) p54b The benzene ring connected to it is arbitrarily p54b R54b This indicates that it is replaced by each R 54b These are the same or different, and each independently, deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or halogenated C 1-6 It represents an alkoxy, and p54b represents an integer of 0, 1, 2, 3, or 4; In formula (PBM-55), (R 55a ) p55a p55a substituents R 55a This represents each R 55a These are the same or different, and each is independently a halogen, hydroxyl, mercapto, cyano, amino, nitro, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 1-6 Alkyl or C halogenated 1-6 It represents an alkoxy, and p55a represents an integer of 0, 1, 2, 3, or 4; R 55b , R 55c They are the same or different, and each is independent of hydrogen, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Represents an alkyl group or an optionally substituted aryl group; R in equation (PBM-55) 55d is a fragment [ka] or [ka] This represents, where the symbol ### represents the connection point with the ring-forming carbon atom, and the symbol **** represents the connection point with the ring-forming nitrogen atom, R 55e represents an arbitrarily substituted aryl or arbitrarily substituted heteroaryl, and R 55f is hydrogen, halogen, C 1-6 Alkyl, halogenated C1-6 Alkyl or deuterated C 1-6 Represents alkyl; and R in each general formula c These are independent of each other: bond, -O-, and -N(R). d )-, -NHC(O)-*, -C(O)NH-*, -N(R d )-R f -N(R e )-*, -R f -C(O)NH-*, -R f -NHC(O)-*, -R f -C(O)O-*, -R f -OC(O)-*, -C(O)O-*, -OC(O)-*, -R f -, -R f -N(R d )-*, -OR f -N(R d )-*, [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] [ka] , or [ka] It represents; In the above formula, each ring W 2 t1 represents an integer of 1 or 2, (R c1 ) m2 Each ring W 2 Each of them independently has an arbitrary m2 R c1 This indicates substitution by the group, and each R c1 Deuterium and C are independent of each other. 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxy, C 2-6 Alkinyl, C 2-6 Alkenyl, optionally deuterated C 3-6 Cycloalkyl, or R c4 -R c3 -and here R c3 is an arbitrarily substituted C 1-6 Alkylene or optionally substituted C 2-6 It is an alkenylene, R c4 is halogen, R c5 R c6N- represents hydroxyl, carboxyl, ethynyl, or vinyl, where R c5 and R c6 They are the same or different, and each is independently of hydrogen or C 1-3 m² represents an alkyl group, and m² represents an integer between 0 and 20; Each ring W 3 t2 is the same or different and each independently represents a heterocyclylene, cycloalkylene, arylene, or heteroarylene, and t2 represents an integer of 0 or 1, (R c2 ) m3 Each ring W 3 These independently have m3 arbitrary R c2 This indicates substitution by the group, and each R c2 Deuterium and C are independent of each other. 1-6 alkyl, deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl, C 1-6 Alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxy, C 2-6 Alkinyl, C 2-6 Alkenyl, optionally deuterated C 3-6 Cycloalkyl, or R c8 -R c7 -and here R c7 is an arbitrarily substituted C 1-6 Alkylene or optionally substituted C 2-6 It is an alkenylene, R c8 is halogen, R c9 R c10 N- represents hydroxyl, carboxyl, ethynyl, or vinyl, where R c9 and R c10 They are the same or different, and each is independently hydrogen or C 1-3 Alkyl represents, and m3 represents an integer from 0 to 20; and R d and R e Each of them independently consists of hydrogen or C 1-6 Represents alkyl, R f and R g Each of these is independently and arbitrarily substituted C 1-6 Alkylene or optionally substituted C 2-6This represents an alkenylene, and the symbol * indicates the connection point with LIN.

[0025] In embodiments of this disclosure, the number of substituents is not limited in principle, or is automatically limited to the size of the constituent unit (i.e., the total number of hydrogen atoms that can be replaced by the constituent unit), or is as clearly defined herein.

[0026] In some embodiments, PBM represents a small molecule ligand of EGFR.

[0027] In some embodiments, the PBM has the structure of the following formula (PBM-1-1A), formula (PBM-1-1B), formula (PBM-1-1C), or formula (PBM-1-1D): [ka] This represents, Here, in equations (PBM-1-1A), (PBM-1-1B), (PBM-1-1C), and (PBM-1-1D), (R 1a ) p1a The benzene ring connected to it has p1a R 1a This indicates that it is replaced by each R 1a These are the same or different, and each is independently of the following: deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, NH2, NO2, cyano, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) represents; p1a represents an integer of 1, 2, 3, 4, or 5; R 1b is a combination, or C 1-3 alkyl, deuterated C 1-3 Alkyl, halogenated C 1-3 C is optionally substituted with substituents selected from the group consisting of alkyls and halogens. 1-2 Represents alkylene; (R 1c ) p1b In formula (PBM-1), the quinazoline ring has p1b R 1c This indicates that it is replaced by each R 1c These are the same or different, and each is independent of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), NO2, cyano, and halogenated carbon. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), C 1-10 Alkyl (for example, C 1-6 Alkyl or C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-10Alkyl (for example, fully deuterated C) 1-6 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-10 Alkoxy (for example, C 1-6 Alkoxy or C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-10 Alkoxy (e.g., C halogenated 1-6 Alkyl or halogenated C 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), heterocyclines with any -O- substitution (e.g., 4-20 member heterocyclines with any -O- substitution), or -NHC(O)R 1e This represents R 1e is C 1-10 Alkyl (for example, C 1-8 Alkyl, C 1-6 Alkyl or C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl), deuterated C 1-10 Alkyl (for example, fully deuterated C) 1-8 alkyl, fully deuterated C 1-6 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C 2-10 Alkenyl (for example, C 2-6 Alkenyl or C 2-4 Represents an alkenyl (e.g., vinyl, propenyl, butenyl, or pentenyl), for example, R 1c is methyl, methoxy, [ka] or [ka] (for example, [ka] ) represents; p1b represents an integer of 1, 2, or 3; and R 1d is hydrogen, deuterium or C 1-3 Represents alkyl.

[0028] In some embodiments, (R 1c ) p1b In equation (PBM-1), the quinazoline ring has p1b R 1c This indicates that it is replaced by, where p1b represents an integer of 1, 2, or 3, and R 1crepresents a heterocyclyl with an optional -O- substitution, wherein the heterocyclyl is a 4- to 20-membered (e.g., 4-15, 4-12, 4-10, 4-7, or 4-6 member) monocyclic, dicyclic, or polycyclic heterocyclyl containing one or more heteroatoms (e.g., 1-4 or 1, 2, 3, or 4) selected from the group consisting of nitrogen, oxygen, and sulfur, such as azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacyclyl This includes, but is not limited to, loheptyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl). In some embodiments, the heterocyclyl is deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, or optionally deuterated C 1-6 Alkyl, halogenated C 1-6 Alkyl, optionally deuterated C 3-6 Cycloalkyl, optionally deuterated C 1-6 Alkoxy, optionally deuterated C 1-6 Alkyl-NH-,NH2-C 1-6 Alkylene, optionally deuterated C 1-6 Alkyl-NHC(O)-, optionally deuterated C 1-6 It is optionally substituted with substituents selected from the group consisting of alkyl-C(O)NH- or any combination thereof. In some embodiments, p1b represents an integer of 1.

[0029] In some embodiments, R 1c teeth, Fluorine, chlorine, bromine, or iodine; Methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl, or octyl; Methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy; -NHC(O)-C 2-10 Alkenyls, for example, -NHC(O)-vinyl (i.e., [ka] ), -NHC(O)-propenyl or -NHC(O)-butenyl; or [ka] (for example, [ka] ) represents.

[0030] In some embodiments, R 1b is a combination, or C 1-3 alkyl, deuterated C 1-3 Alkyl, halogenated C 1-3 C is optionally substituted with substituents selected from the group consisting of alkyls and halogens. 1-2 Represents alkylene. In some embodiments, R 1b is combined, or optionally C 1-3 alkyl, deuterated C 1-3 Alkyl, halogenated C 1-3 R represents a methylene or ethylene substituted with a substituent selected from the group consisting of alkyls and halogens. In some embodiments, R 1b This represents a combination.

[0031] In some embodiments, PBM has the structure of the following formula (PBM-1-1), formula (PBM-1-2), formula (PBM-1-3), formula (PBM-1-4), or formula (PBM-1-5): [ka] It represents.

[0032] In some embodiments, PBM has the structure of the following formula (PBM-2-1A), formula (PBM-2-1B), formula (PBM-2-1C), formula (PBM-2-1D), or formula (PBM-2-1E): [ka] This represents, Here, in equations (PBM-2-1A), (PBM-2-1B), (PBM-2-1C), (PBM-2-1D), and (PBM-2-1E), (R 2a ) p2a The benzene ring connected to it has p2a R 2a This indicates that it is replaced by each R 2a These are the same or different, and each is independent of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), nitro, cyano, and halogenated carbon. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), C 1-10 Alkyl (for example, C 1-8 Alkyl, C 1-6 Alkyl or C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl), deuterated C 1-10 Alkyl (for example, fully deuterated C) 1-8 alkyl, fully deuterated C 1-6 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-10 Alkoxy (for example, C 1-8 Alkoxy, C 1-6 Alkoxy or C1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy) or -NHC(O)R 2d This represents R 2d is C 1-10 Alkyl (for example, C 1-8 Alkyl, C 1-6 Alkyl or C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl), deuterated C 1-10 Alkyl (for example, fully deuterated C) 1-8 alkyl, fully deuterated C 1-6 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C 2-10 Alkenyl (for example, C 2-6 Alkenyl or C 2-4 Represents an alkenyl (e.g., vinyl, propenyl, butenyl, or pentenyl), for example R 2a is methyl, methoxy, nitro or [ka] It represents; p2a represents an integer of 1, 2, 3, or 4; (R 2b ) p2b The 1H-indole ring connected to it has p2b R 2b This indicates that it is replaced by p2b, where p2b represents an integer of 0, 1, 2, or 3, and each R 2b They are the same or different, and each is independent of deuterium and deuterated C. 1-10 Alkyl (for example, fully deuterated C) 1-8 alkyl, fully deuterated C 1-6 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-10 Alkyl (for example, C 1-8 Alkyl, C 1-6 Alkyl or C 1-4Alkyl compounds (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl, or octyl), halogens (e.g., fluorine, chlorine, bromine, or iodine), or C halogenated compounds. 1-10 Alkyl (e.g., C halogenated) 1-6 Alkyl or halogenated C 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and R 2c is hydrogen, C 1-10 Alkyl (for example, C 1-8 Alkyl, C 1-6 Alkyl or C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl), deuterated C 1-10 Alkyl (for example, fully deuterated C) 1-8 alkyl, fully deuterated C 1-6 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), halogen (e.g., fluorine, chlorine, bromine, or iodine), or C halogenated carbon 1-10 Alkyl (e.g., C halogenated) 1-6 Alkyl or halogenated C 1-4 This represents alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-).

[0033] In some embodiments, PBM has the structure of the following formula (PBM-2-1) or formula (PBM-2-2): [ka] It represents.

[0034] In some embodiments, the PBM has the following structure (PBM-3): [ka] This represents, and in the formula, (R 3a ) p3a The benzene ring connected to it has p3a R 3a This indicates that it is replaced by each R 3a They are the same or different, and each is independently of deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), NO2, NH2, or cyano; p3a represents an integer of 0, 1, 2, 3, 4, or 5; R 3b C is either substituted or unsubstituted. 3-15 Cycloalkyl (e.g., substituted or unsubstituted C)3-10 Cycloalkyl or C 3-6 This represents a cycloalkyl group (e.g., cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl). In some embodiments, the C 3-15 Cycloalkyls include deuterium, hydroxyl, amino, mercapto, nitro, halogen (e.g., fluorine, chlorine, bromine, or iodine), cyano, and C. 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), optionally halogenated C 3-6 Cycloalkyl, C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl-NH-,NH2-C 1-6 Alkylene, C 1-6 Alkyl-NHC(O)-, C 1-6 It is optionally substituted with one or more substituents (e.g., 1-3, 1, 2, or 3) selected from the group consisting of alkyl-C(O)NH- or any combination thereof.

[0035] In some embodiments, PBM has the following structure (PBM-3-1): [ka] It represents.

[0036] In some embodiments, PBM has the structure of the following formula (PBM-4-1A), formula (PBM-4-1B), formula (PBM-4-1C), or formula (PBM-4-1D): [ka] This represents, Here, in equations (PBM-4-1A), (PBM-4-1B), (PBM-4-1C), and (PBM-4-1D), R 4a C 6-10 Represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl containing one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), and the C 6-10 Each aryl or 5-20 membered heteroaryl is independently and optionally substituted with a substituent, which can be deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, or C. 1-6 Alkyl (for example, C 1-6 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-5 Alkoxy or C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 One or more alkoxys (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) or any combination thereof, selected from the group (e.g., 1-6, e.g., 1, 2, 3, 4, 5 or 6); R 4b C 6-10 Represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl containing one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), and the C 6-10 Each aryl or 5-20 membered heteroaryl is independently and optionally substituted with a substituent, which can be deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, or C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxys (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy) and halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 One or more (e.g., 1-6, e.g., 1, 2, 3, 4, 5 or 6) selected from the group consisting of alkoxys (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-); and (R 4c ) p4a The isoindoline ring connected to it has any p4a R 4c This indicates that it is replaced by each R 4c They are the same or different, and each is independently of deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), NO2, NH2, C 1-6 Alkoxy (for example, C 1-4Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), or cyano; and p4a represents an integer of 0, 1, 2, or 3.

[0037] In some embodiments, R 4a is C 6-10 The term represents, but is not limited to, aryl, such as phenyl or naphthyl, where phenyl or naphthyl may be optionally substituted with substituents, each independently of deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, or C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6Alkoxy (e.g., C halogenated 1-4 One or more alkoxys (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) or any combination thereof are selected from the group (e.g., 1-6, e.g., 1, 2, 3, 4, 5 or 6).

[0038] In some embodiments, R 4a R represents a 5-20 membered heteroaryl, for example, a heteroaryl comprising one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S. In one sub-embodiment, R 4aThis represents a 5-14 member monocyclic or bicyclic aromatic ring group containing one or more heteroatoms (e.g., 1-6, or 1-5, or 1-4, or 1-3) independently selected from the group consisting of oxygen, nitrogen, and sulfur. In one sub-embodiment, examples of heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2 This includes, but is not limited to, 1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, imidazo[1,2-b]pyridazinyl, or 6,7-dihydro-5H-pyrrolo[1,2-c]imidazolyl. Heteroaryls are each independently composed of deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 It is optionally substituted with one or more substituents (e.g., 1-6 substituents, e.g., 1, 2, 3, 4, 5, or 6 substituents) selected from the group consisting of alkoxy substituents (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-) or any combination thereof.

[0039] In some embodiments, R 4b C 6-10 The aryl group, for example, represents phenyl or naphthyl, but is not limited to these. Phenyl or naphthyl can be any one or more (e.g., 1-6, e.g., 1, 2, 3, 4, 5, or 6) of the R groups defined above. 4d It will be replaced with.

[0040] In some embodiments, R 4b R represents a heteroaryl compound comprising one or two 5- to 7-membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S. In one sub-embodiment, R 4brepresents a 5-14 membered monocyclic or bicyclic aromatic ring group containing one or more heteroatoms (e.g., 1-6, 1-5, 1-4, or 1-3) independently selected from the group consisting of oxygen, nitrogen, and sulfur. In one sub-embodiment, examples of heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1,3] The heteroaryl includes, but is not limited to, oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. The heteroaryl may contain any one or more (e.g., 1-6, e.g., 1, 2, 3, 4, 5, or 6) R as defined above. 4d It will be replaced with.

[0041] In some embodiments, PBM has the structure of the following formula (PBM-4-1), formula (PBM-4-2), formula (PBM-4-3), formula (PBM-4-4), or formula (PBM-4-5): [ka] It represents.

[0042] In some embodiments, the PBM has the structure of the following formula (PBM-5): [ka] This represents, and in the formula, R 5a is hydrogen, C 1-10 Alkyl (for example, C 1-8 Alkyl, C 1-6 Alkyl or C 1-4 Alkyl, for example, methyl, ethyl, propyl, isopropyl ( [ka] ), butyl, sec-butyl, tert-butyl, pentyl, hexyl, heptyl or octyl), deuterated C 1-10 Alkyl (for example, fully deuterated C) 1-8 alkyl, fully deuterated C 1-6 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-10 Alkyl (e.g., C halogenated) 1-8 Alkyl or halogenated C 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and R 5b teeth, [ka] Or it represents a 4-12 member nitrogen-containing heterocycline, where each of the 4-12 member nitrogen-containing heterocyclines is independently a deuterium, a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-5 Alkyl or halogenated C 1-3Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), deuterated C 1-6 Alkoxy (e.g., fully deuterated C) 1-4The substituents are optionally substituted with one or more substituents selected from the group consisting of alkoxys (e.g., CD3-O-, CD3CD2-O-, or CD3CD2CD2-O-), NO2, NH2, cyano, or any combination thereof. In some sub-embodied forms, examples of 4- to 12-membered nitrogen-containing heterocyclines include azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, and aza This includes, but is not limited to, bicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl).

[0043] In some embodiments, PBM has the structure of the following formula (PBM-5-1) or formula (PBM-5-2): [ka] It represents.

[0044] In some embodiments, the PBM has the following structure (PBM-44): [ka] This represents, During the ceremony, R 44a , R 44b , R 44c Each of these independently represents CH or N; R 44d is -C(O)NHR 44h ,-NHC(O)R 44h-S(O)2NHR 44h , -NHS(O)2R 44h -S(O)2R 44h or -P(O)(R 44h ) represents 2, where each R 44h They are the same or different, and each is independent of C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-5 alkyl, fully deuterated C 1-4 Alkyl or fully deuterated C 1-3 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-5 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); (R 44e ) p44a This has 44a substituents R 44e This represents each R 44e These are the same or different, and each is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-5 alkyl, fully deuterated C 1-4Alkyl or fully deuterated C 1-3 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-5 Alkoxy, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Represents alkoxys (e.g., trifluoromethoxy); p44a represents an integer of 0, 1, 2, 3, or 4; (R 44f ) p44b This has 44b substituents R 44f This represents each R 44f These are the same or different, and each is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-5 alkyl, fully deuterated C 1-4 Alkyl or fully deuterated C 1-3 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-5 Alkoxy, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6Alkoxy (e.g., C halogenated 1-4 Represents alkoxys (e.g., trifluoromethoxy); p44b represents an integer of 0, 1, or 2; (R 44g ) p44c The benzene ring connected to it is arbitrarily p44c R 44g This indicates that it is replaced by and each R 44g Each of these is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-5 alkyl, fully deuterated C 1-4 Alkyl or fully deuterated C 1-3 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-5 Alkoxy, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Represents alkoxys (e.g., trifluoromethoxy); and p44c represents an integer of 0, 1, 2, 3, or 4.

[0045] In some embodiments, R 44a and R 44b Each independently represents CH or N. In some sub-embodiments, R 44aCH represents R 44b represents N. In some sub-embodiments, R 44a CH represents R 44b represents CH. In some sub-embodiments, R 44a represents N, and R 44b represents CH. In some sub-embodiments, R 44a represents N, and R 44b This represents N.

[0046] In some embodiments, R 44c represents CH or N. In some sub-embodiments, R 44c represents N. In some sub-embodiments, R 44c CH represents CH.

[0047] In some embodiments, R 44d -C(O)NHR 44h ,-NHC(O)R 44h -S(O)2NHR 44h , -NHS(O)2R 44h -S(O)2R 44h or -P(O)(R 44h ) represents 2, where each R 44h They are the same or different, and each is independent of C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-5 alkyl, fully deuterated C 1-4 Alkyl or fully deuterated C 1-3 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-5 Alkyl or halogenated C 1-3Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-). Several sub-enablings, R 44d is -P(O)(R 44h ) represents 2, where each R 44h They are the same or different, and each is independent of C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-5 alkyl, fully deuterated C 1-4 Alkyl or fully deuterated C 1-3 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-5 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-). Several sub-enablings, R 44d represents -P(O)(CH3)2.

[0048] In some embodiments, p44c represents an integer of 0, 1, 2, 3, or 4. In some sub-embodiments, p44c represents an integer of 2.

[0049] In some embodiments, PBM has the structure of the following formula (PBM-44-1), formula (PBM-44-2), formula (PBM-44-3), formula (PBM-44-4), or formula (PBM-44-5): [ka] [ka] It represents.

[0050] In some embodiments, PBM represents a small molecule ligand of AR.

[0051] In some embodiments, PBM has the structure of the following formula (PBM-6): [ka] This represents, During the ceremony, Ring A is C 6-10 The group A represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl containing one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), and ring A has any one or more (for example, 1-10, 1-8, or 1-6, for example, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) R 6a Replaced by, and each R 6a These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 2-6 Alkenyls (e.g., vinyl, propenyl, or butenyl), or C 2-6 Alkynnyl (e.g., ethynyl, propynyl, or butynyl); Ring B is C 3-15 R represents a cycloalkyl or 4-20 membered heterocycline (e.g., a heterocycline containing 1-4 heteroatoms selected from the group consisting of N, O, and S), where ring B is arbitrarily composed of one or more (e.g., 1-10, 1-8, or 1-6, e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) R 6b Replaced by, and each R 6b They are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-); and Ring C represents a 5-20 membered heteroaryl (e.g., a 5-20 membered monocyclic or bicyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S), where ring C has any one or more R atoms (e.g., 1-10, 1-8, or 1-6, e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10). 6c Replaced by, and each R 6c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 These are alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0052] In some embodiments, PBM has the structure of the following formula (PBM-6-1A): [ka] This represents, During the ceremony, In formula (PBM-6-1A), the benzene ring can be any one or more (e.g., 1-10, 1-8, or 1-6, e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) R 6a Replaced by, and each R 6a These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 2-6 Alkenyls (e.g., vinyl, propenyl, or butenyl), or C 2-6 Alkynnyl (e.g., ethynyl, propynyl, or butynyl); Ring B is C 3-15 R represents a cycloalkyl or 4-20 membered heterocycline (e.g., a heterocycline containing 1-4 heteroatoms selected from the group consisting of N, O, and S), where ring B is arbitrarily composed of one or more (e.g., 1-10, 1-8, or 1-6, e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) R 6b Replaced by, and each R 6b They are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-); Q1 represents N or CH; and In formula (PBM-6-1A), the heteroaryl containing Q1 and a nitrogen atom may have one or more (e.g., 1-3, e.g., 1, 2, or 3) R atoms. 6c Replaced by, and each R 6c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 These are alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0053] In some embodiments, ring B in formula (PBM-6) and formula (PBM-6-1A) is independently C 3-15 Represents a cycloalkyl or a 4-20 membered heterocycline (for example, a heterocycline containing 1-4 heteroatoms selected from the group consisting of N, O, and S). 3-15 Examples of cycloalkyls include cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, dekalinyl, octahydropentarenyl, octahydro-1H-indenyl, 2,3-dihydro-1H-indenyl, and spirocycloalkyl (e.g., C 5-15 This includes, but is not limited to, spirocycloalkyls, adamantanyl, noadamantanyl, and norbornyl. 3-15 The optional substituents on the cycloalkyl group may be deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), and halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Selected from the group consisting of alkoxys (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-). Examples of the aforementioned 4-20 member heterocyclils include azetidinil, oxetanil, pyrrolidinil, imidazolidinil, pyrazolidinil, tetrahydrofuranil, tetrahydropyranil, tetrahydrothienyl, tetrahydrothiopyranil, oxazolidinil, thiazolidinil, piperidinil, piperazinil, morpholinil, thiomorpholinil, dioxacyclohexyl, azacycloheptyl, diazacycloheptanil (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclooctyl, and azabicyl The 4-20 member heterocyclyls may optionally contain, but are not limited to, chloro[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl). Optional substituents on the 4-20 member heterocyclyl may optionally include deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), and halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Selected from the group consisting of alkoxys (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0054] In some embodiments, PBM has the structure of the following formula (PBM-6-1), formula (PBM-6-2), formula (PBM-6-3), or formula (PBM-6-4): [ka] It represents.

[0055] In some embodiments, the PBM has the following structure (PBM-7): [ka] This represents, During the ceremony, R7a R represents a 4-20 membered heterocycline (for example, a heterocycline containing 1-4 heteroatoms selected from the group consisting of N, O, and S), where the 4-20 membered heterocycline can have any one or more (for example, 1-10, 1-8, or 1-6, for example, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) R 7c Replaced by, and each R 7c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-); and (R 7b ) p7aThe benzene ring connected to it has p7a R 7b This indicates that it is replaced by each R 7b They are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 The character represents an alkyl group (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), and p7a represents an integer of 1, 2, 3, or 4.

[0056] In some embodiments, R 7aHere, represents a 4-20 membered heterocyclil (for example, a heterocyclil containing 1-4 heteroatoms selected from the group consisting of N, O, and S), where examples of the 4-20 membered heterocyclils are azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, diazacycloheptanyl (for example, 1,4-diazacycloheptyl) This includes, but is not limited to, 3,8-diazabicyclo[3.2.1]octan-3-yl, 2,5-diazabicyclo[2.2.2]octan-2-yl, azabicyclo[3.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl). In some embodiments, the 4-20 membered heterocyclyl is optionally one or more (e.g., 1-10, 1-8, or 1-6, e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10) R 7c Replaced by, and each R 7c These are the same or different and as defined above.

[0057] In some embodiments, PBM has the structure of the following formula (PBM-7-1), formula (PBM-7-2), formula (PBM-7-3), or formula (PBM-7-4): [ka] It represents.

[0058] In some embodiments, the PBM has the following structure (PBM-50): [ka] This represents, During the ceremony, (R 50a ) p50a The benzene ring connected to it has p50a R 50a This indicates that it is replaced by each R 50a These are the same or different, and each is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkyl-S(O)2, halogenated C 1-6 Alkyl-S(O)2, halogenated C 1-6 Alkyl-NHC(O), C halogenated 1-6 Alkyl-C(O)NH, C halogenated 1-6 Alkyl-NHS(O)2, halogenated C 1-6 Alkyl-S(O)2NH, C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4, where p50a represents an alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), and p50a represents an integer of 0, 1, 2, 3 or 4; and R 50b is hydrogen, C 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-) or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 This represents alkyl groups (for example, CD3, CD3CD2-, CD3CD2CD2-, etc.).

[0059] In some embodiments, PBM has the structure of the following formula (PBM-50-1): [ka] It represents.

[0060] In some embodiments, the PBM has the structure of the following formula (PBM-51): [ka] This represents, During the ceremony, (R 51a ) p51a The benzene ring connected to it has p51a R 51a This indicates that it is replaced by each R51a These are the same or different, and each is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), optionally substituted C 3-15 Represents a cycloalkyl or a 4- to 15-membered heterocycline containing 1-4 heteroatoms selected from the group consisting of optionally substituted N, O, and S, and p51a represents an integer of 0, 1, 2, 3, 4, or 5; (R 51b ) p51b The benzene ring connected to it has p51b R 51b This indicates that it is replaced by each R 51bThese are the same or different, and each is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), optionally substituted C 3-15 Represents a cycloalkyl or a 4- to 15-membered heterocycline containing 1-4 heteroatoms selected from the group consisting of optionally substituted N, O, and S, and p51b represents an integer of 0, 1, 2, 3, or 4; (R 51c ) p51c The isoxazole ring connected to it has any p51c R 51c This indicates that it is replaced by each R 51cThese are the same or different, and each is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 It represents an alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-), and p51c represents an integer of 0, 1, or 2.

[0061] In some embodiments, R 51a and R 51b The same or different, and independently, are arbitrarily substituted C. 3-15 Represents a cycloalkyl or a 4- to 15-membered heterocycline containing 1-4 heteroatoms selected from the group consisting of optionally substituted N, O, and S. 3-15Examples of cycloalkyls include cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, dekalinyl, octahydropentarenyl, octahydro-1H-indenyl, 2,3-dihydro-1H-indenyl, and spirocycloalkyl (e.g., C 5-15 This includes, but is not limited to, spirocycloalkyls, adamantanyl, noadamantanyl, and norbornyl. 3-15 The optional substituents on the cycloalkyl group may optionally be halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, or C. 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), and halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4Selected from the group consisting of alkoxys (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-). Examples of the aforementioned 4- to 15-membered heterocyclils include azetidinil, oxetanil, pyrrolidinil, imidazolidinil, pyrazolidinil, tetrahydrofuranil, tetrahydropyranil, tetrahydrothienyl, tetrahydrothiopyranil, oxazolidinil, thiazolidinil, piperidinil, piperazinil, morpholinil, thiomorpholinil, dioxacyclohexyl, azacycloheptyl, diazacycloheptanil (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclooctyl, and azabicyl. The following are examples of 4- to 15-membered heterocyclyls, including but not limited to chloro[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl). Optional substituents on the 4- to 15-membered heterocyclyls may optionally include halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, mercapto, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, CD3-O-, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), and halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Selected from the group consisting of alkoxys (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0062] In some embodiments, PBM has the structure of the following formula (PBM-51-1): [ka] It represents.

[0063] In some embodiments, the PBM has the following structure (PBM-54): [ka] This represents, During the ceremony, In equation (PBM-54), (R 54a ) p54a This has 54a substituents R 54a This represents each R 54a These are the same or different, and each is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, mercapto, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-5 Alkoxy or C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 The alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) is represented, and p54a represents an integer of 0, 1, 2, 3 or 4; (R 54b ) p54b The benzene ring connected to it is arbitrarily p54b R 54b This indicates that it is replaced by each R 54b These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, mercapto, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 Alkyl or fully deuterated C1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-5 Alkoxy or C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 It represents an alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-), and p54b represents an integer of 0, 1, 2, 3, or 4.

[0064] In some embodiments, PBM has the structure of the following formula (PBM-54-1): [ka] It represents.

[0065] In some embodiments, PBM represents a small molecule ligand of BTK.

[0066] In some embodiments, the PBM has the structure of the following formula (PBM-8): [ka] This represents, During the ceremony, In formula (PBM-8), X1 is N or CR. 8f This represents R 8f represents hydrogen, deuterium, or amino, and X2 is N or CR. 8g This represents R 8g represents hydrogen or a bond, and X3 represents CH or N; R 8a and R 8b Each of these independently represents either a hydrogen atom or a bond; (R 8c ) p8aThe benzene ring connected to it has p8a R 8c This indicates that it is replaced by each R 8c These are the same or different, and each is independently -O-aryl, -O-heteroaryl, 4-20 membered heterocyclyl, and -C 1-3 Alkylene-NHC(O)-heteroaryl, -C 1-3 Alkylene-C(O)NH-heteroaryl, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterium, deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), halogens (e.g., fluorine, chlorine, bromine, or iodine), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-), and the 4-20 membered heterocyclyl, aryl, and heteroaryl each independently have one or more (e.g., 1-5, e.g., 1, 2, 3, 4, or 5) R 8h Replaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated)1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-); p8a represents an integer of 1, 2, 3, or 4; R 8d is a bond, hydrogen, halogen (e.g., fluorine, chlorine, bromine or iodine), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), or C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 This represents alkoxys (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy); R 8e is hydrogen, halogen (e.g., fluorine, chlorine, bromine or iodine), cyano, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), or amino; Here R 8g , R 8a , R 8b and R 8d It is not hydrogen at the same time, and R 8g , R 8a , R 8b and R 8d Only one of them represents a combination, and here R 8a When R represents a combination, 8a The ring-forming carbon atoms connected are directly R cIt is connected to, and X2 represents CH or N, and R 8b is hydrogen, and R 8d It is not a combination; X2 is CR 8g This represents R 8g When R represents a combination, 8g The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b Both are hydrogen, and R 8d It is not a combination; R 8b When R represents a combination, 8b The ring constituent nitrogen atoms connected are directly R c It is connected to, and X2 represents N or CH, and R 8a is hydrogen, and R 8d is not a combination; or R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to and X2 represents N or CH, and R 8a and R 8b Both are hydrogen.

[0067] In some embodiments, R in formula (PBM-8) 8c -O-aryl, -O-heteroaryl, -C 1-3 Alkylene-NHC(O)-heteroaryl, or -C 1-3 This represents alkylene-C(O)NH-heteroaryl, where aryl is an optionally substituted C. 6-10 The heteroaryl group may be an aryl group, including, for example, phenyl or naphthyl, but is not limited thereto. The heteroaryl group may be a 5-14 membered monocyclic, dicyclic, or polycyclic aromatic ring group containing one or more heteroatoms (e.g., 1-6, 1-5, 1-4, or 1-3) independently selected from the group consisting of oxygen, nitrogen, and sulfur, which are optionally substituted. In one sub-embodiment, R 8c R represents -O-phenyl or -O-naphthyl, where phenyl or naphthyl is arbitrarily represented by one or more (e.g., 1-5, e.g., 1, 2, 3, 4, or 5) R 8hReplaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-). In one sub-embodiment, R 8c is -O-heteroaryl, -C 1-3 Alkylene-NHC(O)-heteroaryl, or -C 1-3 The term represents alkylene-C(O)NH-heteroaryl, where the heteroaryl consists of one or more R groups (e.g., 1-5, e.g., 1, 2, 3, 4, or 5).8h Replaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-). In one sub-embodiment, examples of heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, This includes, but is not limited to, nzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, or imidazo[2,1-b]thiazolyl.

[0068] In some embodiments, R in formula (PBM-8) 8c R represents a 4-20 member (e.g., 4-15 member, 4-12 member, 4-10 member, 4-7 member, or 4-6 member) monocyclic, bicyclic, or polycyclic heterocyclil, where the 4-20 member monocyclic, bicyclic, or polycyclic heterocyclil may be optionally substituted. In one sub-embodiment, R 8c R represents a 4-20 member monocyclic, bicyclic, or polycyclic heterocyclil, and a 4-20 member monocyclic, bicyclic, or polycyclic heterocyclil can be any one or more (e.g., 1-5, e.g., 1, 2, 3, 4, or 5) R 8h Replaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C.1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3These are alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-). In one sub-embodiment, examples of 4-20 membered monocyclic, bicyclic, or polycyclic heterocyclines include azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclo This includes, but is not limited to, octyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl).

[0069] In some embodiments, R 8b represents a bond, R 8a is hydrogen, R 8d is not a bond, and X2 represents N or CH.

[0070] In some embodiments, R 8b represents a bond, R 8a is hydrogen, R 8d This is not a combination, and X2 represents N, and X1 represents CR. 8f This represents R 8f It represents hydrogen, or amino acid, and X3 represents N.

[0071] In some embodiments, R 8b represents a bond, R8a is hydrogen, R 8d This is not a combination, and X2 represents N, and X1 represents CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents CH.

[0072] In some embodiments, R 8b represents a bond, R 8a is hydrogen, R 8d This is not a bond, and X2 represents N, X1 represents N, and X3 represents CH.

[0073] In some embodiments, R 8b represents a bond, R 8a is hydrogen, R 8d This is not a combination, and X2 represents N, X1 represents N, and X3 represents N.

[0074] In some embodiments, R 8b represents a bond, R 8a is hydrogen, R 8d X is not a bond, and X2 represents CH, and X1 represents CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents N.

[0075] In some embodiments, R 8b represents a bond, R 8a is hydrogen, R 8d X is not a bond, and X2 represents CH, and X1 represents CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents CH.

[0076] In some embodiments, R 8b represents a bond, R 8a is hydrogen, R 8d X is not a bond, and X2 represents CH, X1 represents N, and X3 represents CH.

[0077] In some embodiments, R8b represents a bond, R 8a is hydrogen, R 8d X is not a bond, and X2 represents CH, X1 represents N, and X3 represents N.

[0078] In some embodiments, R 8a When R represents a combination, 8a The ring-forming carbon atoms connected are directly R c It is connected to, and X2 represents CH or N, and R 8b is hydrogen, and R 8d It is not a combination.

[0079] In some embodiments, R 8a represents a bond, R 8b is hydrogen, R 8d X is not a bond, and X2 represents CH, X1 represents N, and X3 represents N.

[0080] In some embodiments, R 8a represents a bond, R 8b is hydrogen, R 8d X is not a bond, and X2 represents CH, X1 represents N, and X3 represents CH.

[0081] In some embodiments, R 8a represents a bond, R 8b is hydrogen, R 8d X is not a bond, and X2 represents CH, and X1 represents CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents N.

[0082] In some embodiments, R 8a represents a bond, R 8b is hydrogen, R 8d X is not a bond, and X2 represents CH, and X1 represents CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents CH.

[0083] In some embodiments, R 8a represents a bond, R 8b is hydrogen, R 8d This is not a combination, and X2 represents N, and X1 represents CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents N.

[0084] In some embodiments, R 8a represents a bond, R 8b is hydrogen, R 8d This is not a combination, and X2 represents N, and X1 represents CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents CH.

[0085] In some embodiments, R 8a represents a bond, R 8b is hydrogen, R 8d This is not a bond, and X2 represents N, X1 represents N, and X3 represents CH.

[0086] In some embodiments, R 8a represents a bond, R 8b is hydrogen, R 8d This is not a combination, and X2 represents N, X1 represents N, and X3 represents N.

[0087] In some embodiments, X2 is CR 8g This represents R 8g When R represents a combination, 8g The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b Both are hydrogen, and R 8d It is not a combination.

[0088] In some embodiments, X2 is CR 8g This represents R 8g When R represents a combination, 8g The ring-forming carbon atoms connected are directly R cIt is connected to R 8a and R 8b Both are hydrogen, and R 8d This is not a bond, and X1 represents N, and X3 represents CH.

[0089] In some embodiments, X2 is CR 8g This represents R 8g When R represents a combination, 8g The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b Both are hydrogen, and R 8d This is not a combination, and X1 represents N, and X3 represents N.

[0090] In some embodiments, X2 is CR 8g This represents R 8g When R represents a combination, 8g The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b Both are hydrogen, and R 8d It is not a join, and X1 is CR 8f This represents R 8f is hydrogen, or represents amino, and X3 represents CH.

[0091] In some embodiments, X2 is CR 8g This represents R 8g When R represents a combination, 8g The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b Both are hydrogen, and R 8d It is not a join, and X1 is CR 8f This represents R 8f is hydrogen, or represents amino, and X3 represents N.

[0092] In some embodiments, R 8d When R represents a combination, 8dThe ring-forming carbon atoms connected are directly R c It is connected to and X2 represents N or CH, and R 8a and R 8b Both are hydrogen.

[0093] In some embodiments, R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b X1, X2, X2, and X3 represent hydrogen, N, N, and CH.

[0094] In some embodiments, R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b All of these are hydrogen, and X2 represents N, X1 represents N, and X3 represents N.

[0095] In some embodiments, R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b Both are hydrogen, and X2 represents N, and X1 is CR. 8f This represents R 8f Both are hydrogen, and X2 represents N, and X3 represents N.

[0096] In some embodiments, R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b Both are hydrogen, and X2 represents N, and X1 is CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents CH.

[0097] In some embodiments, R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b All of these are hydrogen, and X2 represents CH, X1 represents N, and X3 represents CH.

[0098] In some embodiments, R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b All of these are hydrogen, and X2 represents CH, X1 represents N, and X3 represents N.

[0099] In some embodiments, R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b Both are hydrogen, and X2 represents CH, and X1 is CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents CH.

[0100] In some embodiments, R 8d When R represents a combination, 8d The ring-forming carbon atoms connected are directly R c It is connected to R 8a and R 8b Both are hydrogen, and X2 represents CH, and X1 is CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents N.

[0101] In some embodiments, PBM has the structure of the following formula (PBM-8-1A): [ka] This represents, During the ceremony, In formula (PBM-8-1A), X1 is N or CR. 8f This represents R 8f X is hydrogen or represents amino, X2 represents N or CH, and X3 represents CH or N; (R) in equation (PBM-8-1A) 8c ) p8a The benzene ring connected to it has p8a R 8c This indicates that it is replaced by each R 8c These are the same or different, and each is independently -O-aryl, -O-heteroaryl, 4-20 membered heterocyclyl, and -C 1-3 Alkylene-NHC(O)-heteroaryl, or -C 1-3 Alkylene-C(O)NH-heteroaryl, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterium, deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), halogens (e.g., fluorine, chlorine, bromine, or iodine), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-), where the 4-20 membered heterocyclyl, aryl, and heteroaryl each independently have one or more (e.g., 1-5, e.g., 1, 2, 3, 4, or 5) R 8h Replaced by, and each R 8hThese are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-); p8a represents an integer of 1, 2, 3, or 4; R 8d is hydrogen, halogen (e.g., fluorine, chlorine, bromine or iodine), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), or C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy); for example, R 8d represents hydrogen or methyl; and R 8e is hydrogen, halogen (e.g., fluorine, chlorine, bromine or iodine), cyano, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3This represents alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-) or amino.

[0102] In some embodiments, R in formula (PBM-8-1A) 8c These are -O-aryl, -O-heteroaryl, and -C 1-3 Alkylene-NHC(O)-heteroaryl, or -C 1-3 This represents alkylene-C(O)NH-heteroaryl, where aryl is an optionally substituted C. 6-10 The heteroaryl group may be an aryl group, including, for example, phenyl or naphthyl, but is not limited thereto. The heteroaryl group may be a 5-14 membered monocyclic or bicyclic aromatic ring group containing one or more (e.g., 1-6, 1-5, 1-4, or 1-3) heteroatoms, which are optionally substituted and independently selected from the group consisting of oxygen, nitrogen, and sulfur. In one sub-embodiment, R 8c R represents -O-phenyl or -O-naphthyl, where phenyl or naphthyl is arbitrarily represented by one or more (e.g., 1-5, e.g., 1, 2, 3, 4, or 5) R 8h Replaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-). In one sub-embodiment, R 8c is -O-heteroaryl, -C 1-3 Alkylene-NHC(O)-heteroaryl, or -C 1-3 The term represents alkylene-C(O)NH-heteroaryl, where the heteroaryl consists of one or more R groups (e.g., 1-5, e.g., 1, 2, 3, 4, or 5). 8h Replaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C)1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3 Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-). In one sub-embodiment, examples of heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, This includes, but is not limited to, nzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, or imidazo[2,1-b]thiazolyl.

[0103] In some embodiments, R in formula (PBM-8-1A) 8cR represents a 4-20 member (e.g., 4-15 member, 4-12 member, 4-10 member, 4-7 member, or 4-6 member) monocyclic, bicyclic, or polycyclic heterocyclil, where the 4-20 member monocyclic, bicyclic, or polycyclic heterocyclil may be optionally substituted. In one sub-embodiment, R 8c R represents a 4-20 member monocyclic, bicyclic, or polycyclic heterocyclil, and a 4-20 member monocyclic, bicyclic, or polycyclic heterocyclil can have any one or more (e.g., 1-5, e.g., 1, 2, 3, 4, or 5) R 8h Replaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3These are alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-). In one sub-embodiment, examples of 4-20 membered monocyclic, bicyclic, or polycyclic heterocyclines include azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclo This includes, but is not limited to, octyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl).

[0104] In some embodiments, X1 in formula (PBM-8-1A) represents N, X2 represents N, and X3 represents CH.

[0105] In some embodiments, X1 in formula (PBM-8-1A) represents N, X2 represents N, and X3 represents N.

[0106] In some embodiments, X1 in formula (PBM-8-1A) represents N, X2 represents CH, and X3 represents CH.

[0107] In some embodiments, X1 in formula (PBM-8-1A) represents N, X2 represents CH, and X3 represents N.

[0108] In some embodiments, X1 in formula (PBM-8-1A) is CR 8f This represents R 8f X represents hydrogen or amino, X2 represents N, and X3 represents N.

[0109] In some embodiments, X1 in formula (PBM-8-1A) is CR 8f This represents R 8f X represents hydrogen or amino, X2 represents N, and X3 represents CH.

[0110] In some embodiments, X1 in formula (PBM-8-1A) is CR 8f This represents R 8f X represents hydrogen or amino, X2 represents CH, and X3 represents N.

[0111] In some embodiments, X1 in formula (PBM-8-1A) is CR 8f This represents R 8f X is hydrogen, or represents amino, X2 represents CH, and X3 represents CH.

[0112] In some embodiments, PBM has the following structure: [ka] It represents.

[0113] In some embodiments, PBM has the structure of the following formula (PBM-8-1B): [ka] This represents, During the ceremony, In formula (PBM-8-1B), X1 is N or CR. 8f This represents R 8f is hydrogen, or represents amino, and X3 represents CH or N; In equation (PBM-8-1B), (R 8c ) p8aThe benzene ring connected to it has p8a R 8c This indicates that it is replaced by each R 8c These are the same or different, and each is independently -O-aryl, -O-heteroaryl, 4-20 membered heterocyclyl, and -C 1-3 Alkylene-NHC(O)-heteroaryl, or -C 1-3 Alkylene-C(O)NH-heteroaryl, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterium, deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), halogens (e.g., fluorine, chlorine, bromine, or iodine), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-), where the 4-20 membered heterocyclyl, aryl, and heteroaryl each independently have one or more (e.g., 1-5, e.g., 1, 2, 3, 4, or 5) R 8h Replaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-); p8a represents an integer of 1, 2, 3, or 4; R 8d is hydrogen, halogen (e.g., fluorine, chlorine, bromine or iodine), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), or C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), for example R 8d represents hydrogen or methyl; and R 8e is hydrogen, halogen (e.g., fluorine, chlorine, bromine or iodine), cyano, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 This represents alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-) or amino.

[0114] In some embodiments, R in formula (PBM-8-1B) 8c These are -O-aryl, -O-heteroaryl, and -C 1-3 Alkylene-NHC(O)-heteroaryl, or -C 1-3 This represents alkylene-C(O)NH-heteroaryl, where aryl is an optionally substituted C.6-10 The heteroaryl group may be an aryl group, including, for example, phenyl or naphthyl, but is not limited thereto. The heteroaryl group may be a 5-14 membered monocyclic or bicyclic aromatic ring group containing one or more heteroatoms (e.g., 1-6, 1-5, 1-4, or 1-3) independently selected from the group consisting of oxygen, nitrogen, and sulfur, which are optionally substituted. In one sub-embodiment, R 8c R represents -O-phenyl or -O-naphthyl, where phenyl or naphthyl is arbitrarily represented by one or more (e.g., 1-5, e.g., 1, 2, 3, 4, or 5) R 8h Replaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-). In one sub-embodiment, R 8c is -O-heteroaryl, -C 1-3 Alkylene-NHC(O)-heteroaryl, or -C 1-3 The term represents alkylene-C(O)NH-heteroaryl, where the heteroaryl consists of one or more R groups (e.g., 1-5, e.g., 1, 2, 3, 4, or 5). 8h Replaced by, and each R 8h These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C1-3 Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-). In one sub-embodiment, examples of heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, This includes, but is not limited to, nzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, or imidazo[2,1-b]thiazolyl.

[0115] In some embodiments, R in formula (PBM-8-1B) 8c R represents a 4-20 member (e.g., 4-15 member, 4-12 member, 4-10 member, 4-7 member, or 4-6 member) monocyclic, bicyclic, or polycyclic heterocyclil, where the 4-20 member monocyclic, bicyclic, or polycyclic heterocyclil may be optionally substituted. In one sub-embodiment, R 8c R represents a 4-20 member monocyclic, bicyclic, or polycyclic heterocyclil, and a 4-20 member monocyclic, bicyclic, or polycyclic heterocyclil can have any one or more (e.g., 1-5, e.g., 1, 2, 3, 4, or 5) R 8h Replaced by, and each R 8hThese are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3These are alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-). In one sub-embodiment, examples of 4-20 membered monocyclic, bicyclic, or polycyclic heterocyclines include azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclo This includes, but is not limited to, octyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl).

[0116] In some embodiments, X1 in formula (PBM-8-1B) represents N, and X3 represents CH.

[0117] In some embodiments, X1 in formula (PBM-8-1B) represents N, and X3 represents N.

[0118] In some embodiments, X1 in formula (PBM-8-1B) is CR 8f This represents R 8f is hydrogen, or represents amino, and X3 represents CH.

[0119] In some embodiments, X1 in formula (PBM-8-1B) is CR 8f This represents R8f is hydrogen, or represents amino, and X3 represents N.

[0120] In some embodiments, PBM has the following structure (PBM-8-2): [ka] It represents.

[0121] In some embodiments, the PBM has the following structure (PBM-41): [ka] This represents, During the ceremony, R 41a is hydrogen, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), optionally substituted C 3-15 Cycloalkyl (e.g., optionally substituted C) 3-11 Represents a cycloalkyl or optionally substituted 4-15 member nitrogen-containing heterocycline; R 41b is hydrogen, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), optionally substituted C 3-15 Cycloalkyl (e.g., optionally substituted C) 3-11 Cycloalkyl, optionally substituted 4-15 member nitrogen-containing heterocyclines or NR 41e R 41f This represents R 41e , R 41f They are the same or different, and each is independent of hydrogen, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkyl (e.g., C halogenated) 1-4 This represents an alkyl group (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-) or an optionally substituted 4- to 15-membered heterocycline; R 41c represents N or CH; (R 41d ) p41a The benzene ring connected to it has any p41a R 41d This indicates that it is replaced by each R 41d These are the same or different, and each is independently hydroxy, amino, cyano, halogen (e.g., fluorine, chlorine, bromine, or iodine), C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-5 Alkoxy or C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and p41a represents an integer of 0, 1, 2, 3, or 4.

[0122] In some embodiments, R 41a is C 1-6 Alkyl, for example, represents, but is not limited to, methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, and tert-butyl.

[0123] In some embodiments, R 41a It is hydrogen.

[0124] In some embodiments, R 41a is an arbitrarily substituted C 3-15 Cycloalkyl (e.g., optionally substituted C) 3-11 Represents a cycloalkyl or optionally substituted 4-15 member nitrogen-containing heterocycline. 3-11 Examples of cycloalkyls include cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, dekalinyl, octahydropentarenyl, octahydro-1H-indenyl, 2,3-dihydro-1H-indenyl, C 5-11 This includes, but is not limited to, spirocycloalkyl, adamantanyl, noadamantanyl, and norbornyl. 3-11 The optional substituents on the cycloalkyl group may be deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, or C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy, C halogenated 1-6 alkoxy, optionally C 1-3The group consists of alkyl or halogen-substituted 2-oxoimidazolidinyl (e.g., 3-methyl-2-oxoimidazolidine-1-yl) or any combination thereof. In some embodiments, the optionally substituted 4- to 15-membered nitrogen-containing heterocyclyl is, for example, a 4- to 8-membered (e.g., 4- to 7-membered, 4-6-membered, 5-7-membered, or 5-6-membered) monocyclic or bicyclic heterocyclyl containing one or more (e.g., 1-4, or 1, 2, 3, or 4) optionally substituted heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, and the optionally substituted groups are: azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, diazacycloheptanyl (e.g., 1,4 (e.g., 3,8-diazabicyclo[3.2.1]octanyl), azacyclooctyl, diazabicyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octanyl-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octanyl-2-yl). In some embodiments, the 4-15 member nitrogen-containing heterocyclyl is deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy, C halogenated 1-6 alkoxy, optionally C 1-3 It is optionally substituted with substituents selected from the group consisting of alkyl or halogen-substituted 2-oxoimidazolidinyl (e.g., 3-methyl-2-oxoimidazolidine-1-yl) or any combination thereof.

[0125] In some embodiments, R 41b is an arbitrarily substituted C 3-15 Cycloalkyl (e.g., optionally substituted C) 3-11 Represents a cycloalkyl or optionally substituted 4-15 member nitrogen-containing heterocycline. 3-11 Examples of cycloalkyls include cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, dekalinyl, octahydropentarenyl, octahydro-1H-indenyl, 2,3-dihydro-1H-indenyl, C 5-11 This includes, but is not limited to, spirocycloalkyl, adamantanyl, noadamantanyl, and norbornyl. 3-11 The optional substituents on the cycloalkyl group may be deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, or C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy, C halogenated 1-6 alkoxy, optionally C 1-3The group consists of alkyl or halogen-substituted 2-oxoimidazolidinyl (e.g., 3-methyl-2-oxoimidazolidine-1-yl) or any combination thereof. In some embodiments, the optionally substituted 4- to 15-membered nitrogen-containing heterocyclil is a 4- to 15-membered (e.g., 4- to 12-membered, 4- to 10-membered, 4- to 7-membered, 4- to 6-membered, 5- to 7-membered, or 5- to 6-membered) monocyclic or bicyclic heterocyclil containing one or more (e.g., 1- to 4, or 1, 2, 3, or 4) optionally substituted heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, and the optionally substituted groups are: azetidinyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azacycloheptyl, diazacycloheptanyl ( This includes, but is not limited to, 1,4-diazabicycloheptan-1-yl), azacyclooctyl, diazabicyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl). In some embodiments, the 4-15 member nitrogen-containing heterocycline may optionally contain deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, or C. 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy, C halogenated 1-6 alkoxy, optionally C 1-3 It is substituted with substituents selected from the group consisting of alkyl or halogen-substituted 2-oxoimidazolidinyl (e.g., 3-methyl-2-oxoimidazolidine-1-yl) or any combination thereof. In some embodiments, R 41brepresents piperidinyl, which is optionally substituted with 3-methyl-2-oxoimidazolidine-1-yl.

[0126] In some embodiments, R 41b is NR 41e R 41f This represents R 41e , R 41f They are the same or different, and each is independent of hydrogen, C 1-6 Alkyl (for example, C 1-4 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C halides 1-6 Alkyl (e.g., C halogenated) 1-4This represents an alkyl group (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-) or an optionally substituted 4- to 15-membered heterocycline. In some embodiments, the optionally substituted 4-15 membered heterocyclils are, for example, 4-12 membered, 4-10 membered, 4-7 membered, 4-6 membered, 5-7 membered, or 5-6 membered monocyclic or bicyclic heterocyclils containing one or more optionally substituted heteroatoms (e.g., 1-4, or 1, 2, 3, or 4) selected from the group consisting of nitrogen, oxygen, and sulfur, and the optionally substituted groups are: azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, thiox This includes, but is not limited to, satycyclohexyl, azacycloheptyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclooctyl, azabicyclo[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl). In some embodiments, the 4-15 member heterocycline is deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, C 1-6 Alkyl, halogenated C 1-6 alkyl, deuterated C 1-6 Alkyl, C 3-6 Cycloalkyl, C 1-6 Alkoxy, C halogenated 1-6 alkoxy, optionally C 1-3It is optionally substituted with substituents selected from the group consisting of alkyl or halogen-substituted 2-oxoimidazolidinyl (e.g., 3-methyl-2-oxoimidazolidine-1-yl) or any combination thereof. In some embodiments, R 41b is NR 41e R 41f This represents R 41e represents hydrogen, R 41f This represents tetrahydropyranyl.

[0127] In some embodiments, p41a represents an integer of 0.

[0128] In some embodiments, p41a represents 1, and R 41d ' is a methoxy, methyl, or fluorine atom.

[0129] In some embodiments, PBM has the structure of the following formula (PBM-41-2) or formula (PBM-41-3): [ka] It represents.

[0130] In some embodiments, PBM has the structure of the following formula (PBM-42-1A), formula (PBM-42-1B), or formula (PBM-42-1C): [ka] This represents, Here, in equations (PBM-42-1A), (PBM-42-1B), and (PBM-42-1C), (R 42a ) p42a The benzene ring connected to it has any p42a R 42a This indicates that it is replaced by each R 42a These are the same or different, and each is independently hydroxy, amino, cyano, halogen (e.g., fluorine, chlorine, bromine, or iodine), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p42a represents an integer of 0, 1, 2, 3, 4, or 5; R 42b O, S, C 1-3 Alkylene or halogenated carbon 1-3 Represents alkylene; (R 42c ) p42b The benzene ring connected to it is arbitrarily p42b R 42c This indicates that it is replaced by each R 42c These are the same or different, and each is independently hydroxy, amino, cyano, halogen (e.g., fluorine, chlorine, bromine, or iodine), C 1-6 Alkyl (for example, C1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-4 Alkoxy or C 1-3 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkyl or halogenated C 1-3 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and p42b represents an integer of 0, 1, 2, 3, or 4.

[0131] In some embodiments, R of formula (PBM-42) 42b represents O.

[0132] In some embodiments, R of formula (PBM-42) 42b represents S.

[0133] In some embodiments, R of formula (PBM-42) 42bis C 1-3 Represents alkylene. In some sub-embodiments, R 42b This represents methylene, ethylene, or propylene.

[0134] In some embodiments, R of formula (PBM-42) 42b is halogenated C 1-3 Represents alkylene. In some sub-embodiments, R 42b This represents fluoromethylene or difluoromethylene.

[0135] In some embodiments, PBM has the structure of the following formula (PBM-42-1): [ka] It represents.

[0136] In some embodiments, PBM represents a small molecule ligand of CDK4 / 6.

[0137] In some embodiments, PBM has the structure of the following formula (PBM-9-1A), formula (PBM-9-1B), formula (PBM-9-1C), or formula (PBM-9-1D): [ka] This represents, and here, Each R 9e Each of these is independently deuterium, hydrogen, halogen (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), -C(O)-C 1-6 Alkyl (e.g., -C(O)-C) 1-5 Alkyl or -C(O)-C 1-3 Alkyl, e.g., -C(O)-CH3, -C(O)-CH2CH3), -C(O)-deuterated C 1-6 Alkyl (e.g., -C(O)-deuterated C) 1-5 Alkyl or -C(O)-deuterated C 1-3 Alkyl, e.g., -C(O)-CD3) or -C(O)NR 9f R 9g This represents R 9f , R 9g They are the same or different, and each is independent of hydrogen, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl) or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) and R 9f , R 9g It is not hydrogen at the same time; Each X5 is independently N or CR 9h This represents R 9h is hydrogen, deuterium, halogens (e.g., fluorine, chlorine, bromine or iodine), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl or halogenated C 1-3 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); X6 and X7 each independently represent CH or N; R in equations (PBM-9-1B) and (PBM-9-1D) 9a Each of these independently represents an arbitrarily substituted heteroarylene (for example, a 5-20 membered monocyclic, dicyclic, or polycyclic aromatic ring group containing one or more arbitrarily substituted heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur (e.g., 1-6, 1-5, 1-4, or 1-3)), where each heteroarylene independently represents a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Optionally substituted with one or two substituents selected from the group consisting of alkoxys (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) or any combination thereof; Each R 9b These are, independently, hydrogen and C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or optionally substituted C 3-12 Cycloalkyl (e.g., halogen, C) 1-6 Alkyl, halogenated C 1-6 Alkyl or deuterated C 1-6Represents cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, or cycloheptyl, which are optionally substituted with substituents selected from the group consisting of alkyl groups; Each (R 9c ) p9a Each of these independently has a pyridine ring connected to it, with an arbitrary number of p9a R 9c This indicates that it is replaced by each R 9c They are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), where p9a represents an integer of 0, 1, 2 or 3; and Each (R 9d ) p9bEach of these independently has a bicyclic nitrogen-containing heteroaromatic ring connected to it, with an arbitrary number of p9b R 9d This indicates that it is replaced by each R 9d They are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 The character represents an alkyl group (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-), and p9b represents an integer of 0 or 1.

[0138] In some embodiments, R in formulas (PBM-9-1B) and (PBM-9-1D) 9aEach of these independently represents an arbitrarily substituted heteroarylene, for example, a 5-14 member monocyclic, dicyclic, or polycyclic heteroarylene containing one or more arbitrarily substituted heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur (e.g., 1-6, 1-5, 1-4, or 1-3). Examples of heteroarylenes include furanylene, oxazolylene, isoxazolylene, oxadiazollylene, thienylene, thiazollylene, isothiazollylene, thiadiazollylene, pyrrolylene, imidazollylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridadinylene, pyradinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzooxazolylene, benzoisoxazolylene, benzothiazollylene, benzoisothiazollylene, benzotriazolylene, and benzo[2,1,3]o Xadiazoylene, benzo[2,1,3]thiadiazoylene, benzo[1,2,3]thiadiazoylene, quinolinylene, isoquinolinylene, naphthylidineylene, synolinylene, quinazolinylene, quinoxalinylene, phthalazine, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, 4H-fluoro[3,2-b]pyrrolylene, pyrrolo[2,1-b]thiazoylene, and imidazo[2,1-b]thiazoylene are included, but are not limited to, heteroarylenes containing halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 It is optionally substituted with one or more substituents (e.g., 1-4 substituents, e.g., 1, 2, 3, or 4 substituents) selected from the group consisting of alkoxy substituents (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0139] In some embodiments, PBM has the structure of the following formula (PBM-9-1), formula (PBM-9-2), or formula (PBM-9-3): [ka] It represents.

[0140] In some embodiments, PBM represents a small molecule ligand of ALK.

[0141] In some embodiments, the PBM has the following structure (PBM-10): [ka] This represents, During the ceremony, (R) in equation (PBM-10) 10a ) p10aThe benzene ring connected to it has any p10a R 10a This indicates that it is replaced by each R 10a Each of these is independently deuterium, cyano, halogen (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), and p10a represents an integer of 0, 1, 2, or 3; and (R 10b ) p10b The benzene ring connected to it is arbitrarily p10b R 10b This indicates that it is replaced by each R 10b Each of these is independently deuterium, cyano, halogen (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkyl (for example, C 1-5 Alkyl, C1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), and p10b represents an integer of 0, 1, 2, 3 or 4; and Each R 10c and R 10d They are the same or different, and each is independent of deuterium, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogen (e.g., fluorine, chlorine, bromine, or iodine), C halogenated compounds 1-6 Alkyl (e.g., fluorine, chlorine, bromine, or iodine), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 These are alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0142] In some embodiments, PBM has the following structure (PBM-10-1): [ka] It represents.

[0143] In some embodiments, PBM has the structure of the following formula (PBM-11): [ka] This represents, During the ceremony, In equation (PBM-11), (R 11a ) p11a The benzene ring connected to it has p11a R 11a This indicates that it is replaced by each R 11a These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-4Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.); p11a represents an integer of 1, 2, 3, 4, or 5; or R 11b is NR 11d R 11e This represents R 11d , R 11e They are the same or different, and each is independent of hydrogen, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) and R 11c These include deuterium, hydrogen, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 This represents alkyl groups (for example, CD3, CD3CD2-, CD3CD2CD2-, etc.).

[0144] In some embodiments, PBM has the structure of the following formula (PBM-11-1), (PBM-11-2), or (PBM-11-3): [ka] It represents.

[0145] In some embodiments, PBM has the following structure (PBM-12): [ka] This represents, During the ceremony, X8, X9, X in equation (PBM-12) 10 , X 11 and X 12 They are the same or different, and each independently represents N or CH; R 12a represents a bonded or optionally substituted methylene (e.g., a halogen-substituted methylene); R 12b is -C(O)N(R 12f )R 12e , -N(R 12f )C(O)R 12e -S(O)2N(R 12f )R 12e , -N(R 12f )S(O)2R 12e -S(O)2R 12e or -P(O)(R 12e ) represents 2, where each R 12e They are the same or different, and each is independent of C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) and R 12f is hydrogen or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); In equation (PBM-12), (R 12c ) p12a It is connected to X9 and X 10 A 6-membered ring containing any p12a R 12c This indicates that it is replaced by each R 12c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p12a represents an integer of 0, 1, 2, 3, or 4; and R12d These are deuterium, halogens (e.g., fluorine, chlorine, bromine or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 This represents alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-).

[0146] In some embodiments, R in formula (PBM-12) 12a The symbol represents a combination. In other words, X in equation (PBM-12) 11 and X 12 The six-membered ring containing the NH group is directly connected to -NH-.

[0147] In some embodiments, R in formula (PBM-12) 12aThis represents a methylene group that has been arbitrarily substituted (for example, a methylene group substituted with a halogen).

[0148] In some embodiments, PBM has the structure of the following formula (PBM-12-1A): [ka] This represents, During the ceremony, X8, X9 and X 10 They are the same or different, and each independently represents N or CH; R 12b is -C(O)N(R 12f )R 12e , -N(R 12f )C(O)R 12e -S(O)2N(R 12f )R 12e , -N(R 12f )S(O)2R 12e -S(O)2R 12e or -P(O)(R 12e ) represents 2, where each R 12e They are the same or different, and each is independent of C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) and R 12f is hydrogen or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); (R 12c )p12a It is connected to X9 and X 10 A 6-membered ring containing any p12a R 12c This indicates that it is replaced by each R 12c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p12a represents an integer of 0, 1, 2, 3, or 4; and R 12d These are deuterium, halogens (e.g., fluorine, chlorine, bromine or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 This represents alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-).

[0149] In some embodiments, PBM has the structure of the following formula (PBM-12-1B): [ka] This represents, During the ceremony, X9 and X 10 They are the same or different, and each independently represents N or CH; R 12b is -C(O)N(R 12f )R 12e , -N(R 12f )C(O)R 12e -S(O)2N(R 12f )R 12e, -N(R 12f )S(O)2R 12e -S(O)2R 12e or -P(O)(R 12e ) represents 2, where each R 12e They are the same or different, and each is independent of C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) and R 12f is hydrogen or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); (R 12c ) p12a It is connected to X9 and X 10 A 6-membered ring containing any p12a R 12c This indicates that it is replaced by each R 12c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and p12a represents an integer of 0, 1, 2, 3, or 4.

[0150] In some embodiments, PBM has the structure of the following formula (PBM-12-1) or formula (PBM-12-2): [ka] It represents.

[0151] In some embodiments, PBM represents a small molecule ligand of RET.

[0152] In some embodiments, PBM has the structure of the following formula (PBM-12-1C): [ka] This represents, During the ceremony, X9 and X 10They are the same or different, and each independently represents N or CH; R 12b is -C(O)N(R 12f )R 12e , -N(R 12f )C(O)R 12e -S(O)2N(R 12f )R 12e , -N(R 12f )S(O)2R 12e -S(O)2R 12e or -P(O)(R 12e ) represents 2, where each R 12e They are the same or different, and each is independent of C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) and R 12f is hydrogen or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); (R 12c ) p12a It is connected to X9 and X 10 A 6-membered ring containing any p12a R 12c This indicates that it is replaced by each R 12c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and p12a represents an integer of 0, 1, 2, 3, or 4.

[0153] In some embodiments, PBM has the structure of the following formula (PBM-12-3), formula (PBM-12-4), or formula (PBM-12-5): [ka] It represents.

[0154] In some embodiments, the PBM has the following structure (PBM-13): [ka] This represents, During the ceremony, Each (R 13a ) p13a Each of these is independent, and the benzene ring connected to it has any p13a R 13a This indicates that it is replaced by each R 13a These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and Each p13a is either the same or different, and independently represents an integer of 0, 1, 2, 3, or 4.

[0155] In some embodiments, PBM has the structure of the following formula (PBM-13-1), (PBM-13-2), or (PBM-13-3): [ka] It represents.

[0156] In some embodiments, PBM represents a small molecule ligand of BET.

[0157] In some embodiments, the PBM has the following structure (PBM-14): [ka] This represents, During the ceremony, (R) in equation (PBM-14) 14a ) p14a The benzene ring connected to it has p14a R 14a This indicates that it is replaced by p14a, where p14a represents an integer of 0, 1, 2, 3, 4, or 5, and each R 14a These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C)1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and Each R 14b These are the same or different, and each is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4This represents alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-).

[0158] In some embodiments, R in formula (PBM-14) x This represents a combination.

[0159] In some embodiments, R in formula (PBM-14) x is -C 1-3 Represents alkylene -C(O)-

[0160] In some embodiments, the PBM has the structure of the following formula (PBM-14-1) or (PBM-14-2): [ka] It represents.

[0161] In some embodiments, the PBM has the following structure (PBM-15): [ka] This represents, During the ceremony, (R) in equation (PBM-15) 15a ) p15a The benzene ring connected to it has any p15a R 15a This indicates that it is replaced by each R 15a These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p15a represents an integer of 0, 1, 2, 3, or 4; (R 15b ) p15b The 4-oxo-3,4-dihydroquinazoline ring connected to it has p15b R 15b This indicates that it is replaced by each R 15b These are the same or different, and each is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and p15b represents an integer of 1, 2, 3, or 4.

[0162] In some embodiments, PBM has the structure of the following formula (PBM-15-1): [ka] It represents.

[0163] In some embodiments, the PBM has the following structure (PBM-16): [ka] This represents, During the ceremony, R in equation (PBM-16) 16a C 6-10Represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl containing one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), and the C 6-10 Each aryl or 5-20 member heteroaryl independently has one or more (e.g., 1-10, 1-8, 2-6, 1-5, 1-4, 1-3, or 2-5) R 16d Replaced by, and each R 16d These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 2-6 Alkenyl, or C 2-6 It is alkinyl; In equation (PBM-16), (R 16b ) p16a The 1,2,3,4-tetrahydroquinoline rings connected to it are p16a R 16b This indicates that it is replaced by each R 16b They are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), and C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p16a represents an integer of 0, 1, 2, 3, or 4; In equation (PBM-16), (R 16c ) p16b The benzene ring connected to it has p16b R 16c This indicates that it is replaced by each R16c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and p16b represents an integer of 0, 1, 2, 3, or 4.

[0164] In some embodiments, PBM has the structure of the following formula (PBM-16-1): [ka] It represents.

[0165] In some embodiments, PBM represents a small molecule ligand of BCR-ABL.

[0166] In some embodiments, the PBM has the structure of the following formula (PBM-17): [ka] This represents, During the ceremony, In equation (PBM-17), (R 17a ) p17a The benzene ring connected to it has p17a R 17a This indicates that it is replaced by each R 17a These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p17a represents an integer of 1, 2, 3, 4, or 5; and R 17b is a halogen (e.g., fluorine, chlorine, bromine, or iodine), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 This represents alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-).

[0167] In some embodiments, PBM has the structure of the following formula (PBM-17-1): [ka] It represents.

[0168] In some embodiments, the PBM has the following structure (PBM-18): [ka] This represents, During the ceremony, (R) in equation (PBM-18) 18a ) p18a The quinoline ring connected to it has p18a R 18aThis indicates that it is replaced by each R 18a These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p18a represents an integer of 1, 2, 3, or 4; (R) in equation (PBM-18) 18b ) p18b The benzene ring connected to it has p18b R 18b This indicates that it is replaced by each R 18b These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and p18b represents an integer of 1, 2, 3, 4, or 5.

[0169] In some embodiments, PBM has the structure of the following formula (PBM-18-1): [ka] It represents.

[0170] In some embodiments, PBM has the structure of formula (PBM-19): [ka] This represents, During the ceremony, R 19a represents -NHC(O)- or -C(O)NH-; R 19b -NH-, -N(C 1-6 Represents alkyl)- or ethynylene; Ring D represents a 5-20 member monocyclic, dicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S, (R 19c ) p19a The ring D has an arbitrary number of p19a R 19c This indicates that it is replaced by and each R 19c These are the same or different, and each is independently and optionally substituted with a 5-15 member heteroaryl, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) represents; p19a represents an integer of 0, 1, 2, or 3; Each (R) in equation (PBM-19) 19d ) p19b Each of these independently has a benzene ring connected to it, each independently having an arbitrary number of p19b R 19d This indicates that it is replaced by each R 19d These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and Each p19b is either the same or different, and independently represents an integer of 0, 1, 2, 3, or 4.

[0171] In some embodiments, ring D in formula (PBM-19) represents a 5-20 member monocyclic, bicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S. In one sub-embodiment, examples of 5-20 member monocyclic, bicyclic, or polycyclic heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, ben This includes, but is not limited to, zo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. Heteroaryls may optionally contain p19a R 19c Substituting with, p19a represents an integer of 0, 1, 2, or 3, and each R 19c These are the same or different, and each is independently and optionally substituted with a 5-15 member heteroaryl, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 This represents alkoxy (for example, F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0172] In some embodiments, R in formula (PBM-19) 19crepresents an optionally substituted 5- to 15-membered heteroaryl. In some embodiments, the 5- to 15-membered heteroaryl is a 5- to 14-membered monocyclic or bicyclic aromatic ring group containing one or more heteroatoms (e.g., 1-6, or 1-5, or 1-4, or 1-3) independently selected from the group consisting of oxygen, nitrogen, and sulfur. In some sub-embodiments, examples of heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1 Includes, but is not limited to, oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. The heteroaryl is optionally substituted with one or more substituents (e.g., 1-6 substituents, e.g., 1, 2, 3, 4, 5, or 6 substituents), where the substituents are halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) or any combination thereof are arbitrarily selected from the group.

[0173] In some embodiments, R in formula (PBM-19) 19b represents -NH-.

[0174] In some embodiments, R in formula (PBM-19) 19b This represents ethynylene.

[0175] In some embodiments, PBM has the structure of the following formula (PBM-19-1A): [ka] This represents, During the ceremony, R 19a represents -NHC(O)- or -C(O)NH-; (R 19c ) p19a The pyrimidinyl group connected to it is optionally p19a R 19cThis indicates that it is replaced by and each R 19c These are the same or different, and each is independently and optionally substituted with a 5-15 member heteroaryl, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) represents; p19a represents an integer of 0, 1, 2, or 3; Each (R) in equation (PBM-19-1A) 19d ) p19b Each of these independently has a benzene ring connected to it, each independently having an arbitrary number of p19b R 19d This indicates that it is replaced by each R 19dThese are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and Each p19b is either the same or different, and independently represents an integer of 0, 1, 2, 3, or 4.

[0176] In some embodiments, R in formula (PBM-19-1A) 19crepresents an optionally substituted 5- to 15-membered heteroaryl. In some embodiments, the 5- to 15-membered heteroaryl is a 5- to 14-membered monocyclic or bicyclic aromatic ring group containing one or more heteroatoms (e.g., 1-6, or 1-5, or 1-4, or 1-3) independently selected from the group consisting of oxygen, nitrogen, and sulfur. In some sub-embodiments, examples of heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1 Includes, but is not limited to, oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. The heteroaryl is optionally substituted with one or more substituents (e.g., 1-6 substituents, e.g., 1, 2, 3, 4, 5, or 6 substituents), where the substituents are halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) or any combination thereof are arbitrarily selected from the group.

[0177] In some embodiments, PBM has the structure of the following formula (PBM-19-1): [ka] It represents.

[0178] In some embodiments, PBM has the structure of the following formula (PBM-19-1B): [ka] This represents, During the ceremony, R 19a represents -NHC(O)- or -C(O)NH-; Ring D represents a 5-20 member monocyclic, dicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S, (R 19c ) p19a The ring D has an arbitrary number of p19a R19c This indicates that it is replaced by and each R 19c These are the same or different, and each is independently and optionally substituted with a 5-15 member heteroaryl, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) represents; p19a represents an integer of 0, 1, 2, or 3; Each (R) in equation (PBM-19-1B) 19d ) p19b Each of these independently has a benzene ring connected to it, each independently having an arbitrary number of p19b R 19d This indicates that it is replaced by each R 19dThese are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and Each p19b is either the same or different, and independently represents an integer of 0, 1, 2, 3, or 4.

[0179] In some embodiments, ring D in formula (PBM-19-1B) represents a 5-20 member monocyclic, bicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S. In one sub-embodiment, examples of 5-20 member monocyclic, bicyclic, or polycyclic heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, ben This includes, but is not limited to, zo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. Heteroaryls may optionally contain p19a R 19c Substituting with, p19a represents an integer of 0, 1, 2, or 3, and each R 19c These are the same or different, and each is independently and optionally substituted with a 5-15 member heteroaryl, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 This represents alkoxy (for example, F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0180] In some embodiments, R in formula (PBM-19-1B) 19crepresents an optionally substituted 5- to 15-membered heteroaryl. In some embodiments, the 5- to 15-membered heteroaryl is a 5- to 14-membered monocyclic, bicyclic, or polycyclic aromatic ring group containing one or more heteroatoms (e.g., 1-6, 1-5, 1-4, or 1-3) independently selected from the group consisting of oxygen, nitrogen, and sulfur. In some sub-embodiments, examples of heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1 Includes, but is not limited to, oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. The heteroaryl is optionally substituted with one or more substituents (e.g., 1-6 substituents, e.g., 1, 2, 3, 4, 5, or 6 substituents), where the substituents are halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, or C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) or any combination thereof are arbitrarily selected from the group.

[0181] In some embodiments, PBM has the structure of the following formula (PBM-19-2): [ka] It represents.

[0182] In some embodiments, the PBM has the following structure (PBM-46): [ka] This represents, During the ceremony, R in equation (PBM-46) 46a This represents NHC(O), C(O)NH, NHS(O)2, or S(O)2NH; (R 46b ) p46a The benzene ring connected to it has any p46a R 46b This indicates that it is replaced by and each R46b Each of these is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy) or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, F2ClC-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), and p46a represents an integer of 0, 1, 2, 3, 4 or 5; and (R 46c ) p46b The 1H-pyrazole ring connected to it has an arbitrary number of p46b R 46c This indicates that it is replaced by and each R 46c Each of these is independently a halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy) or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 The alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, F2ClC-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-) is used, and p46b represents an integer of 0, 1, or 2.

[0183] In some embodiments, p46a in formula (PBM-46) represents an integer of 1, and R 46b These include halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy) or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, F2ClC-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-). In some embodiments, R 46b It is F2ClC-O-.

[0184] In some embodiments, R 46a represents NHC(O). In some embodiments, R 46a This represents C(O)NH.

[0185] In some embodiments, p46b represents an integer of 0.

[0186] In some embodiments, PBM has the structure of the following formula (PBM-46-1): [ka] It represents.

[0187] In some embodiments, PBM represents a small molecule ligand of FAK.

[0188] In some embodiments, PBM has the structure of the following formula (PBM-12-1D): [ka] This represents, During the ceremony, X8, X in equation (PBM-12-1D) 11 and X 12 These are the same or different, and each independently represents N or CH; R 12a represents a bonded or optionally substituted methylene (e.g., a halogen-substituted methylene); R 12b is -C(O)N(R 12f )R 12e , -N(R 12f )C(O)R 12e -S(O)2N(R 12f )R 12e , -N(R 12f )S(O)2R 12e -S(O)2R 12e or -P(O)(R 12e ) represents 2, where each R 12e They are the same or different, and each is independent of C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) and R 12 is hydrogen or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); In equation (PBM-12-1D), (R 12c ) p12a The benzene ring connected to it has any p12a R 12c This indicates that it is replaced by each R 12c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy, e.g. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p12a represents an integer of 0, 1, 2, 3, or 4; and R 12d These are deuterium, halogens (e.g., fluorine, chlorine, bromine or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy, e.g. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 This represents alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-).

[0189] In some embodiments, R in formula (PBM-12-1D) 12a X represents a combination. In other words, in equation (PBM-12-1D), X 11 and X 12 The six-membered ring containing is directly connected to -NH-.

[0190] In some embodiments, R in formula (PBM-12-1D) 12a represents a methylene group that has been arbitrarily substituted (for example, a methylene group substituted with a halogen).

[0191] In some embodiments, PBM has the structure of the following formula (PBM-12-1E) or formula (PBM-12-1F): [ka] This represents, During the ceremony, X8, X 11 and X 12 They are the same or different, and each independently represents N or CH; Each R 12g These are the same or different, and each independently represents hydrogen or halogen; R 12b is -C(O)N(R 12f )R 12e , -N(R 12f )C(O)R 12e -S(O)2N(R 12f )R 12e , -N(R 12f )S(O)2R 12e -S(O)2R 12e or -P(O)(R 12e ) represents 2, where each R 12e They are the same or different, and each is independent of C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), or deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) and R 12f is hydrogen or C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl); (R 12c )p12a The benzene ring connected to it has any p12a R 12c This indicates that it is replaced by each R 12c These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy, e.g. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p12a represents an integer of 0, 1, 2, 3, or 4; and R 12d These are deuterium, halogens (e.g., fluorine, chlorine, bromine or iodine), hydroxyl, amino, cyano, and C. 1-6 Alkoxy (for example, C 1-4Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy, e.g. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 This represents alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-).

[0192] In some embodiments, PBM has the structure of the following formulas (PBM-12-6), (PBM-12-7), (PBM-12-8), (PBM-12-9), (PBM-12-10), or (PBM-12-11): [ka] [ka] It represents.

[0193] In some embodiments, the PBM has the structure of the following formula (PBM-47): [ka] This represents, In the formula, R 47a represents N or CH; R 47b represents O, S, NH, CH2, CH(F), or C(F)2; R 47c represents a bonded or optionally substituted methylene (e.g., a halogen-substituted methylene); Ring I is C 6-15 (R represents an aryl, a 4-15 membered heterocyclyl, or a 5-15 membered heteroaryl, 47d ) p47a The ring I connected to it has any p47a R 47d This indicates that it is replaced by and each R 47d They are the same or different, and each independently, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, oxo group, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-), where p47a represents an integer of 0, 1, 2, 3, or 4; (R 47e ) p47b R is connected to it. 47a A 6-membered nitrogen-containing heteroaromatic ring containing any p47b R 47e This indicates that it is replaced by each R 47e These include deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy, e.g. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-) is represented, and p47b represents an integer of 0, 1, or 2; (R 47f ) p47c The benzene ring connected to it has any p47c R 47f This indicates that it is replaced by each R 47f These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy, e.g. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 The character represents an alkyl group (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-), and p47c represents an integer of 0, 1, 2, 3, or 4.

[0194] In some embodiments, R 47a This represents N.

[0195] In some embodiments, R 47a CH represents CH.

[0196] In some embodiments, R 47c This represents a combination.

[0197] In some embodiments, R 47c represents a methylene molecule that has been optionally substituted (for example, a methylene molecule that has been optionally substituted with a halogen (e.g., fluorine, chlorine, bromine, or iodine)).

[0198] In some embodiments, ring I is C 6-15 Represents aryl, 4-15 member heterocyclyl, or 5-15 member heteroaryl. 6-15Examples of aryls include, but are not limited to, phenyl and naphthyl. Examples of 4- to 15-membered heterocyclyls include azetidinyl, oxetanyl, pyrrolidinyl, imidazolidinyl, pyrazolidinyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothienyl, tetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, diazacycloheptanyl (e.g., 1,4-diazacycloheptan-1-yl), azacyclooctyl, diazacyclooctyl, azabicic This includes, but is not limited to, ro[3.1.1]heptanyl, azabicyclo[2.2.1]heptanyl, azabicyclo[3.2.1]octanyl, azabicyclo[2.2.2]octanyl, diazabicyclo[3.1.1]heptanyl, diazabicyclo[2.2.1]heptanyl, diazabicyclo[3.2.1]octanyl (e.g., 3,8-diazabicyclo[3.2.1]octan-3-yl), and diazabicyclo[2.2.2]octanyl (e.g., 2,5-diazabicyclo[2.2.2]octan-2-yl). Examples of 5-15 member heteroaryls include furanil, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, isoindolinyl, benzofuranil, isobenzofuranil, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1,3 This includes, but is not limited to, oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl, and imidazo[2,1-b]thiazolyl.

[0199] In some embodiments, (R in formula (PBM-47) 47d ) p47a The ring I has any p47a R 47d This indicates that it is replaced by and each R 47d They are the same or different, and each independently, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, oxo group, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 The alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-) is used, and p47a represents an integer of 0, 1, 2, 3, or 4.

[0200] In some embodiments, ring I represents isoindolinyl, and it optionally has an additional p47a R 47d Replaced by, and each R 47d They are the same or different, and each independently, deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, nitro, oxo group, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 The ring I is an alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-), and p47a represents an integer of 0, 1, 2, 3, or 4. In some embodiments, p47a represents an integer of 0, 1, 2, 3, or 4. In some embodiments, ring I represents isoindolinyl, which optionally further comprises a halogen (e.g., fluorine, chlorine, bromine, or iodine), an oxo group, and C 1-6 Alkyl (for example, C 1-5 Alkyl, C1-4 Alkyl or C 1-3 Substituted with alkyl groups (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl).

[0201] In some embodiments, (R 47e ) p47b R is connected to it. 47a A 6-membered nitrogen-containing heteroaromatic ring containing any p47b R 47e This indicates that it is replaced by each R 47e These include deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4R represents an alkyl group (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-), and p47b represents an integer of 0, 1, or 2. In some embodiments, each R 47e Each of these is independently deuterium, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl) or halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 It represents an alkyl group (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-), and p47b represents an integer of 0, 1, or 2.

[0202] In some embodiments, (R 47f ) p47c The benzene ring connected to it has any p47c R 47f This indicates that it is replaced by each R 47f These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, nitro, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 The R represents an alkyl group (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-), and p47c represents an integer of 0, 1, 2, 3, or 4. In some embodiments, each R 47f Each of these independently contains a halogen (e.g., fluorine, chlorine, bromine, or iodine) or C 1-6 Alkoxy (for example, C 1-4 p47c represents an alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy, or tert-butoxy), and p47c represents an integer of 0, 1, 2, 3, or 4.

[0203] In some embodiments, PBM has the structure of the following formulas: (PBM-47-1A), (PBM-47-1B), (PBM-47-1C), (PBM-47-2A), (PBM-47-2B), or (PBM-47-2C): [ka] [ka] This represents, In the formula, R 47a , R 47c , (R 47d ) p47a , (R 47e ) p47b and (R47f ) p47c This is as defined in each embodiment and each sub-embodiment of formula (PBM-47).

[0204] In some embodiments, PBM has the structure of the following formula (PBM-47-1), formula (PBM-47-2), formula (PBM-47-3), or formula (PBM-47-4): [ka] It represents.

[0205] In some embodiments, PBM represents a small molecule ligand of ER.

[0206] In some embodiments, PBM has the structure of the following formula (PBM-20-1A), formula (PBM-20-1B), formula (PBM-20-1C), or formula (PBM-20-1D): [ka] This represents, and in the formula, R 20a , R 20b , R 20c and R 20d These are the same or different, and each is independently of hydrogen, deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); In formulas (PBM-20-1A), (PBM-20-1B), (PBM-20-1C), and (PBM-20-1D), the symbol "~~~" connecting the double bond represents the possible spatial configuration (cis or trans, or E- or Z- configuration); Each (R 20e ) p20a Each of these independently has a benzene ring connected to it, each independently and arbitrarily having p20a R 20e This indicates that it is replaced by each R 20e These are the same or different, and each is independently of deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.) or C halogenated 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); and Each p20a is either the same or different, and independently represents an integer of 0, 1, 2, 3, or 4.

[0207] In some embodiments, PBM has the structure of the following formulas (PBM-20-1), (PBM-20-2), (PBM-20-3), (PBM-20-4), (PBM-20-5), (PBM-20-6), (PBM-20-7), (PBM-20-8), (PBM-20-9), or (PBM-20-10): [ka] [ka] It represents.

[0208] In some embodiments, PBM has the structure of the following formula (PBM-21-1A) or formula (PBM-21-1B): [ka] This represents, During the ceremony, Each R 21d Each of these independently represents O, S, or CH2; (R 21c ) p21a p21a R 21cR represents a substituent, that is, in formula (PBM-21), 21d A 10-membered ring containing any p21a R 21c This indicates that it is replaced by each R 21c These are the same or different, and each is independently of hydrogen, hydroxyl, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-); p21a represents an integer of 0, 1, 2, 3, or 4; and R 21a and R 21b These are, independently, hydrogen, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkoxy (for example, C1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl compounds (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), or C halides. 1-6 Alkyl (e.g., C halogenated) 1-4 This represents alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-).

[0209] In some embodiments, PBM has the structure of the following formulas (PBM-21-1), (PBM-21-2), (PBM-21-3), (PBM-21-4), (PBM-21-5), (PBM-21-6), (PBM-21-7), (PBM-21-8), (PBM-21-9), (PBM-21-10), (PBM-21-11), or (PBM-21-12): [ka] [ka] It represents.

[0210] In some embodiments, PBM represents a small molecule ligand of IRAK4.

[0211] In some embodiments, the PBM has the following structure (PBM-22): [ka] This represents, During the ceremony, In formula (PBM-22), ring E represents a 5-20 member monocyclic, dicyclic, or polycyclic heteroarylene containing 1-4 heteroatoms selected from the group consisting of N, O, and S; R 22b This includes optionally substituted 5-15 member heteroaryls, optionally substituted 5-15 member heterocyclines, deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4Alkoxy (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) represents; R 22a is hydrogen, halogen (e.g., fluorine, chlorine, bromine or iodine), C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 This represents alkoxy (for example, F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0212] In some embodiments, the ring E in formula (PBM-22) represents a 5-20 member monocyclic, dicyclic, or polycyclic heteroarylene containing 1-4 heteroatoms selected from the group consisting of N, O, and S. In some embodiments, the 5-20 member monocyclic, dicyclic, or polycyclic heteroarylene represents a 5-14 member monocyclic, dicyclic, or polycyclic divalent aromatic ring group containing 1-4 (e.g., 1-4, 1-3, 1-2, or 1) heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur. In some sub-embodiments, examples of 5-20 membered monocyclic, bicyclic, or polycyclic heteroarylenes include furanylene, oxazolylene, isoxazolylene, oxadiazollylene, thienylene, thiazollylene, isothiazollylene, thiadiazollylene, pyrrolylene, imidazollylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridadinylene, pyradinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzooxazolylene, benzoisoxazolylene, benzothiazollylene, benzoisothiazollylene, benzotri This includes, but is not limited to, zolylene, benzo[2,1,3]oxadiazoylene, benzo[2,1,3]thiadiazoylene, benzo[1,2,3]thiadiazoylene, quinolinylene, isoquinolinylene, naphthylidineylene, sinnolinylene, quinazolinylene, quinoxalinylene, phthalazine, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, pyrrolo[2,1-b]thiazoylene, imidazo[2,1-b]thiazoylene, or imidazo[1,2-b]pyridadinylene. A 5-20 member monocyclic, bicyclic, or polycyclic heteroarylene may optionally have one or more substituents R 22b Replaced by each R 22b These are, independently, optionally substituted 5-15 member heteroaryls, optionally substituted 5-15 member heterocyclines, deuterium, halogens (e.g., fluorine, chlorine, bromine, or iodine), hydroxyl, cyano, amino, and C. 1-6 Alkyl (for example, C1-5 Alkyl, C 1-4 Alkyl or C 1-3 Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy compounds (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), or halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 This represents alkoxy (for example, F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O-, or CH2ClCH2-O-).

[0213] In some embodiments, R in formula (PBM-22) 22brepresents an optionally substituted 5-15 member heteroaryl. In some embodiments, a 5-15 member heteroaryl is a 5-15 member monocyclic, bicyclic, or polycyclic aromatic ring group containing 1-4 heteroatoms (e.g., 1-4, 1-3, 1-2, or 1) independently selected from the group consisting of oxygen, nitrogen, and sulfur. In some sub-embodiments, examples of heteroaryls are furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyridadinyl, pyrazinyl, indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothienyl, indazolyl, benzimidazolyl, benzoxazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1 Includes, but is not limited to, oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolyl, isoquinolyl, naphthilidinyl, sinnolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, pyrrolo[2,1-b]thiazolyl, imidazo[2,1-b]thiazolyl, or imidazo[1,2-b]pyridazinyl. 22b The heteroaryl represented by is optionally substituted with one or more further substituents (e.g., 1-3, e.g., 1, 2, or 3), where the substituents are optionally -N(R 22c )-C 1-6 Alkylene-optionally substituted C 3-8 Cycloalkyl, -N(R 22c )-Optionally halogenated C 1-6 Alkyl, halogen (e.g., fluorine, chlorine, bromine, or iodine), hydroxy, cyano, amino, C 1-6 Alkyl (for example, C 1-5 Alkyl, C 1-4 Alkyl or C 1-3Alkyl (e.g., methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, or hexyl), halogenated C 1-6 Alkyl (e.g., C halogenated) 1-4 Alkyl (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), deuterated C 1-6 Alkyl (for example, fully deuterated C) 1-6 alkyl, fully deuterated C 1-5 Alkyl or fully deuterated C 1-4 Alkyl (e.g., CD3, CD3CD2-, CD3CD2CD2-, etc.), C 1-6 Alkoxy (for example, C 1-4 Alkoxy (e.g., methoxy, ethoxy, propoxy, isopropoxy, butoxy, sec-butoxy or tert-butoxy), halogenated C 1-6 Alkoxy (e.g., C halogenated 1-4 Alkoxy compounds (e.g., F3C-O-, FCH2-O-, F2CH-O-, ClCH2-O-, Cl2CH-O-, CF3CF2-O-, CF3CHF-O-, CHF2CF2-O-, CHF2CHF-O-, CF3CH2-O- or CH2ClCH2-O-) or any combination thereof are selected from the group, where each R 22c These are independently hydrogen or C 1-3 Represents alkyl. In some embodiments, R 22b The substituents of the heteroaryl represented are -N(R 22c )-C 1-6 Alkylene-optionally substituted C 3-8 It is a cycloalkyl, where R 22c is hydrogen or C 1-3 Represents alkyl (e.g., methyl). In some embodiments, C 1-6 An example of alkylene is C 1-3 This includes, but is not limited to, alkylenes. In some embodiments, C 3-8 An example of a cycloalkyl group is C 3-6 This includes, but is not limited to, cycloalkyl groups. In some embodiments, C3-8 Typical examples of cycloalkyls include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, and cyclooctyl. 3-8 Cycloalkyl groups can optionally be further C1-C3 alkyl groups. 3-6 Cycloalkyl, hydroxy, amino, mercapto, halogen,...

Claims

1. A compound of formula (I) or a salt, enantiomer, stereoisomer, solvate, isotopically enriched analogue, prodrug or polymorph thereof, PBM-LIN-ULM Formula (I) In formula (I), PBM represents a target moiety capable of binding to a protein, and PBM is covalently bound to ULM via the group LIN; ULM represents a ligand moiety capable of binding to an E3 ubiquitin ligase and represents the structure of the following formula (ULM), [Chemical 1] Formula (ULM) In formula (ULM), A represents N or CH; R ａ１ 、R ａ２ 、R ａ３ and R ａ４ are the same or different and each independently represents hydrogen, deuterium, halogen, C １－６ alkyl, halogenated C １－６ alkyl, deuterated C １－６ alkyl, C １－６ alkoxy, deuterated C １－６ alkoxy or halogenated C １－６ alkoxy; Ring W １ represents arylene or heteroarylene, and said ring W １ is optionally substituted with m R ａ５ s, each R ａ５ is the same or different and each independently represents halogen, hydroxy, mercapto, nitro, amino, cyano, C １－６ alkyl, halogenated C １－６ alkyl, deuterated C １－６ alkyl, C １－６ alkoxy, deuterated C １－６ alkoxy, halogenated C １－６ alkoxy, C ２－６ alkenyl, or C ２－６ alkynyl; m represents an integer of 0, 1, 2, 3 or 4; X is a bond, or -R ｂ１-N(R) ａ６ )-R ｂ２ - represents, and here R ａ６ is hydrogen or C １－６ Represents alkyl, and R ｂ１ and R ｂ２ Each of these is an arbitrarily substituted C, independently of the others. ０－２ Represents alkylene; LIN is the linker portion, consisting of a bond, optionally substituted methylene, or optionally substituted linear or branched C. ２－１５ This represents alkylene, where the C of the straight-chain or branched chain is... ２－１５ Between one or more pairs of adjacent carbon atoms in the alkylene carbon backbone, ａ , R ｂ And one or more groups selected from the group consisting of any combination thereof are arbitrarily interposed, and each group R ａ These are O, C(O), OC(O), S, S(O), S(O) respectively, independently of each other. ２ , S(O) ２ N(R) ａ７ ), N (R ａ７ ) S(O) ２ , C(O)N(R ａ７ ), N (R ａ７ ) C(O), N(R ａ７ ) and N(R ａ７ ) C(O)N(R ａ７ A group consisting of ) is selected, where each R ａ７ Each is independently H or C １－３ Represents alkyl, and the linear or branched C ２－３０ The alkylene carbon backbone has two or more groups R ａ When intervening, each base R ａ They are not directly connected to each other; each base R ｂ Each of these is independently selected from the group consisting of optionally substituted cycloalkylenes, optionally substituted arylenes, optionally substituted heterocyclylenes, optionally substituted heteroarylenes, alkylylenes, alkenylenes, and any combination thereof, and is a compound of formula (I) or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analogue, pharmaceutical precursor, or polymorph.

2. The aforementioned PBMs are the following proteins: epidermal growth factor receptor (EGFR), cyclin-dependent kinase 4 / 6 (CDK4 / 6), cyclin-dependent kinase 2 (CDK2), anaplastic lymphoma kinase (ALK), activin receptor-like kinase 2 (ALK2), and fibroblast growth factor receptor (FIBC). receptors (FGFRs), proto-oncogene tyrosine protein kinase receptor RET (RET), focal adhesion kinase (FAK), breakpoint cluster region (BCR)-Abelson leukemia virus (ABL) (BCR-ABL) tyrosine kinase, Bruton tyrosine kinase (BTK), androgen receptor (AR), estrogen receptor (Estrogen Proteins with a receptor (ER), bromododomain and extra-terminal domain (BET), interleukin-1 receptor-associated kinase 4 (IRAK4), cyclin-dependent kinase 9 (CDK9), histone-lysine N-methyltransferase EZH2 (EZH2), neurotrophic factor receptor tyrosine kinase Kinase, NTRK), Src homology 2-domain protein tyrosine phosphatase (SrcHomology 2 domain containing protein tyrosine phosphorase (SHP2), poly[ADP-ribose] polymerase (PARP), signaling and transcription activator 3 (STAT3), FMS-like tyrosine kinase 3 (FLT3), BCL-2 (B cell lymphoma-2) family proteins, SOS Ras / Rac guanine nucleotide exchange factor 1 (SOS Ras / Rac guanine NUCLEOTIDE EXCHANGE 1 (SOS1) or GTPase KRas (KRAS), SWI / SNF-related matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 2 / 4 (SMARCA2 / 4) or ribosomal protein S6 kinase (ribosomal protein S6 A compound of formula (I) according to claim 1, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph representing a small molecule ligand that binds to kinase (RSK).

3. The aforementioned PBM is given by the following formula: [chemical 2] [C3] [C4] [C5] [C6] [C7] [C8] [C9] [C10] [C11] [C12] [C13] [C14] [C15] It includes a structure selected from the group consisting of; In the above formula, (R) in equation (PBM-1) １ａ ) ｐ１ａ The benzene ring connected to it is p1a R １ａ This indicates that it is replaced by each R １ａ They are the same or different, and each is independently deuterium, halogen, hydroxyl, NH ２ NO ２ , cyano, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents alkoxy; p1a represents an integer of 1, 2, 3, 4, or 5; R １ｂ is combined, or C １－３ Alkyl, deuterated C １－３ Alkyl, halogenated C １－３ C optionally substituted with substituents selected from the group consisting of alkyls and halogens １－２ Represents alkylene; (R １ｃ ) ｐ１ｂ In formula (PBM-1), the quinazoline ring has p1b R １ｃ This indicates that it is replaced by each R １ｃ They are the same or different, and each is independently deuterium, halogen, NO ２ , cyano, halogenated C １－６ Alkyl, C １－１０ Alkyl, deuterated C １－１０ Alkyl, C １－１０ Alkoxy, C halogenated １－１０ Alkoxy, -O- optionally substituted heterocyclyl, or -NHC(O)R １ｅ represents, where R １ｅ is C １－１０ alkyl, deuterated C １－１０ alkyl or C ２－１０ alkenyl, for example R １ｃ is methyl, methoxy, 【Chemical Formula 16】 or 【Chemical Formula 17】 , for example 【Chemical Formula 18】 represents; p1b represents an integer of 1, 2 or 3; R １ｄ is hydrogen, deuterium or C １－３ alkyl; In formula (PBM-2), (R ２ａ ), ｐ２ａ means that the benzene ring connected thereto is substituted with p2a number of R ２ａ , each R ２ａ is the same or different and each independently represents deuterium, halogen, nitro, cyano, halogenated C １－６ alkyl, C １－１０ alkyl, deuterated C １－１０ alkyl, C １－１０ alkoxy or -NHC(O)R ２ｄ , where R ２ｄ is C １－１０ alkyl, deuterated C １－１０ alkyl or C ２－１０ alkenyl, for example R ２ａ is methyl, methoxy, nitro or 【Chemical Formula 16】 represents; p2a represents an integer of 1, 2, 3 or 4; (R ２ｂ ), ｐ２ｂ means that the 1H-indole ring in formula (PBM-2) is substituted with p2b number of R ２ｂ , p2b represents an integer of 0, 1, 2 or 3, and each R ２ｂ is the same or different and each independently represents deuterium, deuterated C １－１０ Alkyl, C １－１０ Alkyl, halogen, or halogenated C １－１０ Represents alkyl; R ２ｃ is hydrogen, C １－１０ Alkyl, deuterated C １－１０ Alkyl, halogen, or halogenated C １－１０ Represents alkyl; (R) in equation (PBM-3) ３ａ ) ｐ３ａ The benzene ring connected to it is p3a R ３ａ This indicates that it is replaced by each R ３ａ They are the same or different, and each is independently deuterium, halogen, hydroxyl, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, NO ２ NH ２ Or it represents cyano; p3a represents an integer of 0, 1, 2, 3, 4, or 5; R ３ｂ C is either substituted or unsubstituted. ３－１５ Represents cycloalkyl groups, such as cyclopentyl; R in equation (PBM-4) ４ａ C ６－１０ Represents an aryl or a 5-20 member heteroaryl, and the C ６－１０ Each aryl or 5-20 membered heteroaryl is independently and optionally substituted with a substituent, which independently may be deuterium, halogen, hydroxyl, cyano, amino, nitro, or C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ One or more elements selected from the group consisting of alkoxys or any combination thereof; R ４ｂ C ６－１０This represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl comprising one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), where C ６－１０ The aryl and the 5-20 member heteroaryl each have one or more R independent of each other. ４ｄ Replaced by, and each R ４ｄ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It is an alkoxy; (R ４ｃ ) ｐ４ａ In formula (PBM-4), the isoindoline ring has an arbitrary number of p4a R ４ｃ This indicates that it is replaced by each R ４ｃ They are the same or different, and each is independently deuterium, halogen, hydroxyl, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, NO ２ NH ２ , C １－６ Alkoxy, C halogenated １－６ Represents alkoxy or cyano; p4a represents an integer of 0, 1, 2, or 3; R in equation (PBM-5) ５ａ is hydrogen, C １－１０ Alkyl (for example, [C19] ), deuterated C １－１０ Alkyl or halogenated C １－１０ Represents alkyl; R ５ｂ teeth, [C20] Or it represents a 4- to 12-membered nitrogen-containing heterocycline, where each of the 4- to 12-membered nitrogen-containing heterocyclines is independently deuterium, halogen, hydroxyl, and C. １－６Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkoxy, NO ２ NH ２ , optionally substituted with one or more substituents selected from the group consisting of cyano or any combination thereof; In formula (PBM-6), ring A is C ６－１０ Represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl containing one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), wherein ring A optionally contains one or more R ６ａ Replaced by, and each R ６ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ２－６ Alkenyl, or C ２－６ It is alkinyl; In equation (PBM-6), ring B is C ３－１５ Represents a cycloalkyl or 4-20 membered heterocycline (for example, a heterocycline containing 1-4 heteroatoms selected from the group consisting of N, O, and S), where ring B is arbitrarily one or more R ６ｂ Replaced by, and each R ６ｂ They are the same or different, and each is independently deuterium, halogen, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It is an alkoxy; In formula (PBM-6), ring C represents a 5-20 membered heteroaryl (for example, a 5-20 membered monocyclic or bicyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S), and ring C may optionally contain one or more R ６ｃ Replaced by, and each R ６ｃ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It is an alkoxy; R in equation (PBM-7) ７ａ R represents a 4- to 20-membered heterocycline (for example, a heterocycline containing 1 to 4 heteroatoms selected from the group consisting of N, O, and S), where the 4- to 20-membered heterocycline can optionally contain one or more R ７ｃ Replaced by, and each R ７ｃ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It is an alkoxy; (R) in equation (PBM-7) ７ｂ ) ｐ７ａ The benzene ring connected to it has p7a R ７ｂ This indicates that it is replaced by each R ７ｂ They are the same or different, and each is independently deuterium, halogen, C １－６ Alkyl, halogenated C １－６ Alkyl or deuterated C １－６ Represents alkyl, where p7a represents an integer of 1, 2, 3, or 4; X in formula (PBM-8) １ is N or CR ８ｆ This represents R ８ｆ represents hydrogen, deuterium, or amino, X ２ is N or CR ８ｇThis represents R ８ｇ represents hydrogen or a bond, and X ３ represents CH or N; R ８ａ and R ８ｂ Each of these independently represents a hydrogen atom or a bond; (R) in equation (PBM-8) ８ｃ ) ｐ８ａ The benzene ring connected to it has p8a R ８ｃ This indicates that it is replaced by each R ８ｃ These are the same or different, and each is independently -O-aryl, -O-heteroaryl, 4-20 membered heterocyclyl, and -C １－３ Alkylene-NHC(O)-heteroaryl, -C １－３ Alkylene-C(O)NH-heteroaryl, C １－６ alkyl, deuterium, deuterated C １－６ Alkyl, halogen, or C halogenated １－６ Representing alkyl, the 4-20 membered heterocyclyl, aryl, and heteroaryl each independently may have one or more R ８ｈ Replaced by, and each R ８ｈ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It is an alkoxy; p8a represents an integer of 1, 2, 3, or 4; R ８ｄ is a bond, hydrogen, halogen, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkoxy, or C １－６ Represents alkoxy; R ８ｅ is hydrogen, halogen, cyano, C １－６ Alkyl, halogenated C １－６ Represents alkyl or amino; Here, R ８ｇ, R ８ａ , R ８ｂ and R ８ｄ It is not hydrogen at the same time, and R ８ｇ , R ８ａ , R ８ｂ and R ８ｄ Only one of them represents a combination, and here, R ８ａ When R represents a combination, ８ａ The ring-forming carbon atoms connected are directly R ｃ Connected to оX ２ represents CH or N, and R ８ｂ is hydrogen, and R ８ｄ It is not a combination; X ２ CR ８ｇ This represents R ８ｇ When R represents a combination, ８ｇ The ring constituent carbon atoms connected are directly R ｃ It is connected to R ８ａ and R ８ｂ Both are hydrogen, and R ８ｄ It is not a combination; R ８ｂ When R represents a combination, ８ｂ The ring constituent nitrogen atoms connected are directly R ｃ Connected to оX ２ represents N or CH, and R ８ａ is hydrogen, and R ８ｄ is not a combination; and R ８ｄ When R represents a combination, ８ｄ The ring-forming carbon atoms connected are directly R ｃ Connected to and X ２ represents N or CH, and R ８ａ and R ８ｂ Both are hydrogen; X in equation (PBM-9) ４ CR ９ｅ or fragment [C21] This represents, where the sign # is X ４ This represents a connection point to an adjacent N, and the sign ## is X ５ This represents the connection point with, and each R ９ｅThese are independently deuterium, hydrogen, halogen, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, -C(O)-C １－６ Alkyl, -C(O)-deuterated C １－６ Alkyl or -C(O)NR ９ｆ R ９ｇ This represents R ９ｆ , R ９ｇ They are the same or different, and each is independent of hydrogen, C １－６ Alkyl or deuterated C １－６ Represents alkyl; X in equation (PBM-9) ５ is N or CR ９ｈ This represents R ９ｈ is hydrogen, deuterium, halogen, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; X ６ and X ７ Each of these independently represents CH or N; R ９ａ represents a bond or optionally substituted heteroarylene (e.g., heteroarylene substituted with halogen or deuterium); R ９ｂ is hydrogen, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl or optionally substituted C ３－１２ Represents a cycloalkyl group; (R) in equation (PBM-9) ９ｃ ) ｐ９ａ The pyridine ring connected to it has an arbitrary number of p9a R ９ｃ This indicates that it is replaced by each R ９ｃ They are the same or different, and each is independently deuterium, halogen, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６Represents alkyl, where p9a represents an integer of 0, 1, 2, or 3; (R) in equation (PBM-9) ９ｄ ) ｐ９ｂ The bicyclic nitrogen-containing heteroaromatic ring connected to it has any p9b R ９ｄ This indicates that it is replaced by each R ９ｄ They are the same or different, and each is independently deuterium, halogen, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl, where p9b represents an integer of 0 or 1; (R) in equation (PBM-10) １０ａ ) ｐ１０ａ The benzene ring connected to it is arbitrarily p10a R １０ａ This indicates that it is replaced by each R １０ａ They are the same or different, and each is independently deuterium, cyano, halogen, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C halogenated １－６ Alkyl or deuterated C １－６ Represents alkyl, where p10a represents an integer of 0, 1, 2, or 3; (R １０ｂ ) ｐ１０ｂ The benzene ring connected to it is arbitrarily p10b R １０ｂ This indicates that it is replaced by each R １０ｂ They are the same or different, and each is independently deuterium, cyano, halogen, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C halogenated １－６ Alkyl or deuterated C １－６ Represents an alkyl group, where p10b represents an integer of 0, 1, 2, 3, or 4; Each R １０ｃ and R １０ｄ They are the same or different, and each is independent of deuterium, C １－６ Alkyl, halogen, C halogen １－６Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It is an alkoxy; (R) in equation (PBM-11) １１ａ ) ｐ１１ａ The benzene ring connected to it is p11a R １１ａ This indicates that it is replaced by each R １１ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C halogenated １－６ Alkyl or deuterated C １－６ Represents alkyl; p11a represents an integer of 1, 2, 3, 4, or 5; R １１ｂ NR １１ｄ R １１ｅ This represents R １１ｄ , R １１ｅ They are the same or different, and each is independent of hydrogen, C １－６ Alkyl, halogenated C １－６ Alkyl or deuterated C １－６ Represents alkyl; R １１ｃ These are deuterium, hydrogen, halogen, hydroxyl, amino, cyano, and C. １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C halogenated １－６ Alkyl or deuterated C １－６ Represents alkyl; X in equation (PBM-12) ８ , X ９ , X １０ , X １１ and X １２ They are the same or different, and each independently represents N or CH; R １２ａ represents a bond or optionally substituted methylene (e.g., a halogen-substituted methylene); R １２ｂ is -C(O)N(R １２ｆ ) R １２ｅ , -N(R １２ｆ ) C(O)R １２ｅ , -S(O) ２ N(R) １２ｆ ) R １２ｅ , -N(R １２ｆ ) S(O) ２ R １２ｅ , -S(O) ２ R １２ｅ or -P(O)(R １２ｅ ) ２ This represents, where each R １２ｅ They are the same or different, and each is independent of the others, C １－６ Alkyl or deuterated C １－６ R represents alkyl. １２ｆ is hydrogen or C １－６ Represents alkyl; (R) in equation (PBM-12) １２ｃ ) ｐ１２ａ X connected to it ９ and X １０ A 6-membered ring containing any p12a R １２ｃ This indicates that it is replaced by each R １２ｃ They are the same or different, and each independently, deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p12a represents an integer of 0, 1, 2, 3, or 4; R １２ｄ Deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; Each (R) in formula (PBM-13) １３ａ ) ｐ１３ａ Each of these independently has a benzene ring connected to it with any p13a R １３ａ This indicates that it is replaced by each R １３ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; Each p13a is the same or different and independently represents an integer of 0, 1, 2, 3, or 4; (R) in equation (PBM-14) １４ａ ) ｐ１４ａ The benzene ring connected to it has p14a R １４ａ This indicates that it is replaced by p14a, where p14a represents an integer of 0, 1, 2, 3, 4, or 5, and each R １４ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; Each R １４ｂ These are the same or different, and each independently of the others, halogen, hydroxy, amino, cyano, and C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; R in equation (PBM-14) ｘ is a combination, or -C １－３ Represents alkylene-C(O)-; (R) in equation (PBM-15) １５ａ ) ｐ１５ａ The benzene ring connected to it is arbitrarily p15a R １５ａ This indicates that it is replaced by each R １５ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p15a represents an integer of 0, 1, 2, 3, or 4; (R １５ｂ ) ｐ１５ｂ The 4-oxo-3,4-dihydroquinazoline ring connected to it has p15b R １５ｂ This indicates that it is replaced by each R １５ｂ These are the same or different, and each independently of the others, halogen, hydroxy, amino, cyano, and C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p15b represents an integer of 1, 2, 3, or 4; R in equation (PBM-16) １６ａ C ６－１０ Represents an aryl or a 5-20 membered heteroaryl (for example, a heteroaryl containing one or two 5-7 membered rings and 1-4 heteroatoms selected from the group consisting of N, O, and S), and the C ６－１０ Each aryl or 5-20 member heteroaryl can independently have one or more R １６ｄ Replaced by, and each R １６ｄ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ２－６ Alkenyl, or C ２－６ It is alkinyl; (R) in equation (PBM-16) １６ｂ ) ｐ１６ａ The 1,2,3,4-tetrahydroquinoline rings connected to it are p16a R １６ｂ This indicates that it is replaced by each R １６ｂThey are the same or different, and each is independently deuterium, halogen, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p16a represents an integer of 0, 1, 2, 3, or 4; (R) in equation (PBM-16) １６ｃ ) ｐ１６ｂ The benzene ring connected to it is p16b R １６ｃ Represents each R １６ｃ They are the same or different, and each independently, deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p16b represents an integer of 0, 1, 2, 3, or 4; (R) in equation (PBM-17) １７ａ ) ｐ１７ａ The benzene ring connected to it has p17a R １７ａ This indicates that it is replaced by each R １７ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p17a represents an integer of 1, 2, 3, 4, or 5; R １７ｂ is halogen, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; (R) in equation (PBM-18) １８ａ ) ｐ１８ａ The quinoline ring connected to it has p18a R １８ａThis indicates that it is replaced by each R １８ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p18a represents an integer of 1, 2, 3, or 4; (R) in equation (PBM-18) １８ｂ ) ｐ１８ｂ The benzene ring connected to it is p18b R １８ｂ This indicates that it is replaced by each R １８ｂ They are the same or different, and each independently, deuterium, halogen, hydroxyl, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p18b represents an integer of 1, 2, 3, 4, or 5; R in equation (PBM-19) １９ａ represents -NHC(O)- or -C(O)NH-; R １９ｂ is -NH-, -N(C １－６ Represents alkyl or ethynylene; In formula (PBM-19), ring D represents a 5-20 member monocyclic, dicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S, (R １９ｃ ) ｐ１９ The ring D has p19a R １９ｃ This indicates that it is replaced by and each R １９ｃ These are the same or different, and each independently, optionally substituted 5-15 member heteroaryl, deuterium, halogen, hydroxyl, cyano, amino, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents alkoxy; p19a represents an integer of 0, 1, 2, or 3; Each (R) in formula (PBM-19) １９ｄ ) ｐ１９ｂ Each of these independently has a benzene ring connected to it that independently has an arbitrary number of p19b R １９ｄ This indicates that it is replaced by each R １９ｄ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; Each p19b is the same or different and independently represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-20) ２０ａ , R ２０ｂ , R ２０ｃ and R ２０ｄ Each of these is independently bonded: hydrogen, deuterium, halogen, hydroxyl, cyano, amino, and C. １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ This represents alkyl, where R ２０ａ , R ２０ｂ , R ２０ｃ and R ２０ｄ Only one of the elements represents a bond, while the other three are the same or different and each independently represents hydrogen, halogen, or hydroxyl, where R ２０ａ , R ２０ｂ , R ２０ｃ and R ２０ｄ If one of the elements represents a bond, the benzene ring or methylene group in the formula (PBM-20) connected to it is directly R ｃ Connected; The symbol " in formula (PBM-20) connects the double bond [C22] " represents possible couplings in spatial configuration (cis or trans, or E- or Z- configuration); Each (R) in formula (PBM-20) ２０ｅ ) ｐ２０ａ Each of these independently has a benzene ring connected to it, each independently and arbitrarily having p20a R ２０ｅ This indicates that it is replaced by each R ２０ｅ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; Each p20a is the same or different and independently represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-21) ２１ｄ is O, S or CH ２ It represents; (R ２１ｃ ) ｐ２１ａ p21a R ２１ｃ Each R represents a substituent. ２１ｃ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p21a represents an integer of 0, 1, 2, 3, or 4; R ２１ａ and R ２１ｂ Only one of the elements represents a bond, and the other is hydrogen, halogen, hydroxyl, cyano, amino, or C. １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ This represents alkyl, where R ２１ａ and R ２１ｂIf one of the terms represents a bond, then the carbon atom of the benzene ring connected to it in formula (PBM-21) is directly R ｃ Connected; In formula (PBM-22), ring E represents a 5-20 membered monocyclic, dicyclic, or polycyclic heteroarylene containing 1-4 heteroatoms selected from the group consisting of N, O, and S; R ２２ｂ These are optionally substituted 5-15 member heteroaryls, optionally substituted 5-15 member heterocyclines, deuterium, halogens, hydroxyl, cyano, amino, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents alkoxy; R ２２ａ is hydrogen, halogen, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents alkoxy; R in equation (PBM-23) ２３ａ These are optionally substituted 5- to 15-membered heterocyclines, optionally substituted 5- to 15-membered heteroaryls, deuterium, halogens, hydroxyl, cyano, amino, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents alkoxy; R ２３ｂ This represents a 5-20 membered monocyclic, dicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S, wherein the heteroaryl may optionally contain deuterium, halogen, hydroxyl, cyano, amino, or C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６Substituted with one or more substituents selected from the group consisting of alkoxys or any combination thereof; (R ２４ａ ) ｐ２４ａ In formula (PBM-24), the isoquinoline ring has an arbitrary number of p24a R ２４ａ This indicates that it is replaced by each R ２４ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, -C(O)NH ２ , deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p24a represents an integer of 0, 1, 2, 3, or 4; (R ２４ｂ ) ｐ２４ｂ In formula (PBM-24), the pyrrolidone ring has an arbitrary number of p24b R ２４ｂ This indicates that it is replaced by each R ２４ｂ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, -C(O)NH ２ , deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p24b represents an integer of 0, 1, 2, 3, or 4; In equation (PBM-24), y represents an integer of 1, 2, or 3; R in equation (PBM-25) ２５ｇ is N or CR ２５ｈ This represents R ２５ｈ represents hydrogen or halogen, R ２５ｉ is N or CR ２５ｊ This represents R ２５ｊ represents hydrogen or halogen; R ２５ｆ The bonds are -C(O)NH-, -NHC(O)-, and -S(O). ２ NH- or -NHS(O) ２ - represents; (R ２５ａ ) ｐ２５ａ R in equation (PBM-25) ２５ｇ and R ２５ｉ A 6-membered ring containing any p25a R ２５ａ This indicates that it is replaced by each R ２５ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p25a represents an integer of 0, 1, or 2; R ２５ｂ is hydrogen, halogen, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl or -C １－３ Alkylene-C ３－６ Represents a cycloalkyl group; R ２５ｃ is hydrogen, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; or R ２５ｂ and R ２５ｃ These, together with the corresponding nitrogen and carbon atoms attached to them, form optionally substituted 5- to 7-membered nitrogen-containing heterorings; R ２５ｄ R represents hydrogen or a bond. ２５ｅ represents hydrogen or a bond, where R ２５ｄ and R ２５ｅ It is not hydrogen at the same time, and R ２５ｄ and R ２５ｅ Only one of the elements represents a bond, and the other represents hydrogen, where R ２５ｄ When R represents a combination, ２５ｄ The ring-forming carbon atoms connected are directly R ｃ Connected to and R ２５ｅ When R represents a combination, ２５ｅThe ring constituent carbon atoms connected are directly R ｃ Connected; R in equation (PBM-26) ２６ａ C １－３ Alkylene or halogenated carbon １－３ Represents alkylene; R ２６ｂ is a halogen, optionally substituted C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ alkoxy, or optionally substituted C ３－１５ Represents a cycloalkyl group; (R ２６ｃ ) ｐ２６ａ In formula (PBM-26), the benzene ring has an arbitrary number of p26a R ２６ｃ This indicates that it is replaced by each R ２６ｃ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p26a represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-27) ２７ａ C １－３ Alkylene or halogenated carbon １－３ Represents alkylene; R ２７ｂ is deuterium, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl or optionally substituted C ３－６ Represents a cycloalkyl group; R ２７ｃ and R ２７ｄ Each of these independently represents either S or O; R in equation (PBM-28) ２８ａ C １－３ Alkylene or halogenated carbon １－３ Represents alkylene; (R ２８ｂ ) ｐ２８ａThe pyrazolo[1,5-a]pyrimidine ring connected to it has an arbitrary number of p28a R ２８ｂ This indicates that it is replaced by each R ２８ｂ They are the same or different, and each is independently hydroxy, halogen, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p28a represents an integer of 0, 1, 2, or 3; R ２８ｃ and R ２８ｄ The two are the same or different, and each is independently of hydrogen, or optionally substituted C. １－１０ Alkyl or optionally substituted C ３－６ Represents a cycloalkyl group; (R ２８ｅ ) ｐ２８ｂ The benzene ring connected to it is arbitrarily p28b R ２８ｅ This indicates that it is replaced by each R ２８ｅ They are the same or different, and each is independent of the others, halogen, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p28b represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-29) ２９ａ is -S- or fragment [C23] This represents R ２９ａ When -S- represents R in equation (PBM-29) ２９ａ And the heteroaryl ring containing the nitrogen atom is a thiazolyl ring, and R ２９ａ fragment [C23] When representing R in formula (PBM-29), ２９ａ And a heteroaryl ring containing a nitrogen atom is a pyridyl ring; R ２９ｂ represents N or CH; R ２９ｃ is hydrogen or optionally substituted C １－１０ Represents alkyl; R ２９ｄ is hydrogen, -C １－３ Alkylene represents an optionally substituted 4- to 10-membered heterocycline, or an optionally substituted 4- to 10-membered heterocycline; R ２９ｅ is hydroxy, halogen, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; R in equation (PBM-30) ３０ａ represents O or S; R ３０ｂ represents N or CH; R ３０ｃ and R ３０ｄ They are the same or different, and each is independently hydroxy, halogen, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; (R ３０ｅ ) ｐ３０ａ The benzene ring connected to it is arbitrarily p30a R ３０ｅ This indicates that it is replaced by each R ３０ｅ They are the same or different, and each independently, deuterium, hydroxyl, halogen, amino, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, -S(O) ２ NH ２ or -C(O)NH ２ It represents; p30a represents an integer of 0, 1, 2, 3, 4, or 5; R in equation (PBM-31) ３１ａ is C(O)NH, NHC(O), (CH ２ ) １－２ C(O)NH, (CH ２ ) １－２ NHC(O), C(O)NH(CH ２ ) １－２ ,NHC(O)(CH ２ ) １－２ , S(O) ２ NH or NHS(O) ２ It represents; R ３１ｂ is hydrogen, hydroxyl, halogen, cyano, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; R ３１ｃ is hydrogen, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; or R ３１ｂ and R ３１ｃ Together with the carbon atoms, nitrogen atoms, and carbon atoms on the benzene ring connected to the nitrogen atoms, they form optionally substituted 4-6 membered heteroaromatic rings or optionally substituted 4-6 membered heterorings; R ３１ｄ is an arbitrarily substituted C ３－６ Cycloalkyl, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Represents an alkyl or optionally substituted 4- to 20-membered heterocycline; (R ３１ｅ ) ｐ３１ａ The pyridine-2(1H)-one ring connected to it has p31a R ３１ｅ This indicates that it is replaced by each R ３１ｅ These are the same or different, and each is independently hydroxy, halogen, cyano, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p31a represents an integer of 0, 1, 2, or 3; In formula (PBM-31), ring F represents an arylene, or a 5-20 membered monocyclic or bicyclic heteroarylene containing 1-4 heteroatoms selected from the group consisting of N, O, and S; (R ３１ｆ ) ｐ３１ｂ The ring F has an arbitrary number of p31b R ３１ｆ This indicates that it is replaced by and each R ３１ｆ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents alkoxy; p31b represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-32) ３２ｃ is an arbitrarily substituted C １－３ Represents alkylene; (R ３２ａ ) ｐ３２ａ The benzene ring connected to it has p32a R ３２ａ This indicates that it is replaced by each R ３２ａ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p32a represents an integer of 0, 1, 2, 3, 4, or 5; (R ３２ｂ ) ｐ３２ｂ The 1H-indazole ring connected to it has p32b R ３２ｂ This indicates that it is replaced by each R ３２ｂ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p32b represents an integer of 0, 1, 2, 3, 4, or 5; R ３２ｄ is C(O)NH, NHC(O), S(O) ２ NH or NHS(O) ２ It represents; R ３２ｅ NR ３２ｆ R ３２ｇ This represents R ３２ｆ , R ３２ｇ They are the same or different, and each is independent of hydrogen, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, optionally substituted C ３－６ Represents a cycloalkyl or optionally substituted 4- to 8-membered heterocycline; X in equation (PBM-33) １３ , X １４ and X １５ These represent CH or N, which are the same or different and independent of each other, where X １３ , X １４ and X １５ It is not N at the same time, and X １３ , X １４ and X １５ The six-membered ring containing halogen, hydroxy, cyano, amino, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl, halogenated C １－６ Optionally substituted with one or two substituents selected from the group consisting of alkyl groups or any combination thereof; In formula (PBM-33), ring G represents a pyrrole ring, imidazole ring, pyrazole ring, benzene ring, pyridine ring, pyrimidine ring, or pyrazine ring; (R ３３ａ ) ｐ３３ａThe benzene ring connected to it is arbitrarily p33a R ３３ａ This indicates that it is replaced by each R ３３ａ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p33a represents an integer of 0, 1, 2, 3, 4, or 5; (R ３３ｂ ) ｐ３３ｂ The pyrrolidine ring connected to it is arbitrarily p33b R ３３ｂ This indicates that it is replaced by each R ３３ｂ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p33b represents an integer of 0, 1, 2, 3, 4, 5, or 6; R ３３ｃ and R ３３ｄ They are the same or different, and each independently, hydrogen, halogen, hydroxyl, amino, cyano, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; (R ３３ｅ ) ｐ３３ｃ The ring G connected to it has an arbitrary number of p33c R ３３ｅ This indicates that it is replaced by each R ３３ｅ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６Alkyl or halogenated C １－６ represents alkyl; p33c represents an integer of 0 or 1; X in formula (PBM-34) １６ , X １７ and X １８ each independently represents CH or N; R ３４ａ represents a bond, S or NH; R ３４ｂ represents a bond, optionally substituted cycloalkyl or optionally substituted 4- to 15-member nitrogen-containing heterocyclyl; R ３４ｃ represents a bond, halogen, amino, hydroxy, cyano, C １－６ alkyl, C １－６ alkoxy, halogenated C １－６ alkoxy, deuterated C １－６ alkyl, halogenated C １－６ alkyl, optionally substituted cycloalkyl or optionally substituted 4- to 15-member nitrogen-containing heterocyclyl; where R ３４ｂ and R ３４ｃ are not simultaneously a bond, and only one of R ３４ｂ and R ３４ｃ is a bond. Here, when R ３４ｂ represents a bond, the ring-constituting carbon atom connected to R ３４ｂ is directly connected to R ｃ , and when R ３４ｃ represents a bond, the ring-constituting carbon atom connected to R ３４ｃ is directly connected to R ｃ ; (R ３４ｄ ) ｐ３４ａ represents that the 6-membered ring connected thereto is optionally substituted with p34a R ３４ｄ groups. Each R ３４ｄ is the same or different and each independently represents hydroxy, amino, cyano, halogen, C １－６ alkyl, C １－６ alkoxy, halogenated C １－６ alkoxy, deuterated C １－６ alkyl or halogenated C １－６ alkyl; p34a represents an integer of 0, 1, 2, 3, or 4; (R ３４ｅ ) ｐ３４ｂ The nitrogen-containing six-membered heteroaromatic ring connected to it has any p34b R ３４ｅ This indicates that it is replaced by each R ３４ｅ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p34b represents an integer of 0, 1, or 2; (R) in equation (PBM-35) ３５ａ ) ｐ３５ａ The phthalazinone ring connected to it has an arbitrary number of p35a R ３５ａ This indicates that it is replaced by each R ３５ａ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p35a represents an integer of 0, 1, 2, 3, or 4; R ３５ｂ is an arbitrarily substituted C １－３ Represents alkylene; (R ３５ｃ ) ｐ３５ｂ The benzene ring connected to it is arbitrarily p35b R ３５ｃ This indicates that it is replaced by each R ３５ｃ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p35b represents an integer of 0, 1, 2, 3 or 4; (R in formula (PBM-36) ３６ａ ) ｐ３６ａ indicates that the 2H-indazole ring connected thereto is optionally substituted with p36a R ３６ａ Each R ３６ａ is the same or different and each independently represents hydroxy, amino, cyano, halogen, C １－６ alkyl, C １－６ alkoxy, halogenated C １－６ alkoxy, deuterated C １－６ alkyl or halogenated C １－６ alkyl; p36a represents an integer of 0, 1, 2 or 3; (R ３６ｂ ) ｐ３６ｂ indicates that the benzene ring connected thereto is optionally substituted with p36b R ３６ｂ Each R ３６ｂ is the same or different and each independently represents hydroxy, amino, cyano, halogen, C １－６ alkyl, C １－６ alkoxy, halogenated C １－６ alkoxy, deuterated C １－６ alkyl or halogenated C １－６ alkyl; p36b represents an integer of 0, 1, 2, 3 or 4; (R in formula (PBM-37) ３７ａ ) ｐ３７ａ indicates that the benzofuran ring connected thereto is optionally substituted with p37a R ３７ａ Each R ３７ａ is the same or different and each independently represents hydroxy, amino, cyano, halogen, C １－６ alkyl, C １－６ alkoxy, halogenated C １－６ alkoxy, deuterated C １－６ alkyl or halogenated C １－６ alkyl; p37a represents an integer of 0, 1, 2 or 3; (R ３７ｂ ) ｐ３７ｂThe benzene ring connected to it is arbitrarily p37b R ３７ｂ This indicates that it is replaced by each R ３７ｂ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p37b represents an integer of 0, 1, 2, or 3; (R) in equation (PBM-38) ３８ａ ) ｐ３８ａ The benzene ring connected to it has an arbitrary number of p38a R ３８ａ This indicates that it is replaced by each R ３８ａ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p38a represents an integer of 0, 1, 2, 3, or 4; R ３８ｂ , R ３８ｃ , R ３８ｄ They are the same or different, and each independently, hydrogen, deuterium, hydroxyl, amino, cyano, halogen, C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; R in equation (PBM-39) ３９ａ , R ３９ｂ They are the same or different, and each is independently hydrogen, halogen, and C １－３ Alkyl or halogenated C １－３ Represents alkyl; R ３９ｃ is a bond, hydrogen, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; y1 represents an integer of 1, 2, or 3; R ３９ｄ The structure of the following formula is: [C24] This represents, In the formula, R ３９ｅ (R represents a bond or hydrogen; ３９ｆ ) ｐ３９ａ The benzene ring connected to it has an arbitrary number of p39a R ３９ｆ This indicates that it is replaced by each R ３９ｆ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl, and p39a represents an integer of 0, 1, 2, 3 or 4; y2 represents an integer of 1, 2 or 3; or R ３９ｄ The structure of the following formula is: [C25] This represents, In the formula, (R ３９ｇ ) ｐ３９ｂ Each of these is independent, and the benzene rings connected to it are arbitrarily p39b R ３９ｇ This indicates that it is replaced by each R ３９ｇ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ The integer represents an alkyl group, and p39b represents an integer of 0, 1, 2, 3, 4, or 5; Here, R ３９ｃ and R ３９ｅ It is not a bond at the same time, and R ３９ｃ and R ３９ｅ Only one of them represents a bond, and here R ３９ｃ When R represents a combination, ３９ｃThe ring constituent nitrogen atoms connected are directly R ｃ Connected to and R ３９ｅ When R represents a combination, ３９ｅ The ring-forming carbon atoms connected are directly R ｃ Connected; In formula (PBM-40), (R ４０ａ ) ｐ４０ａ The benzene ring connected to it is arbitrarily p40a R ４０ａ This indicates that it is replaced by each R ４０ａ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p40a represents an integer of 0, 1, 2, 3, or 4; R in formula (PBM-40) ｘ３ represents a bond, or C(O); R in equation (PBM-41) ４１ａ is hydrogen, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, optionally substituted C ３－１５ Represents a cycloalkyl or optionally substituted 4- to 15-membered nitrogen-containing heterocycline; R ４１ｂ is hydrogen, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, optionally substituted C ３－１５ Cycloalkyl, optionally substituted 4-15 member nitrogen-containing heterocyclyl or NR ４１ｅ R ４１ｆ This represents R ４１ｅ , R ４１ｆ They are the same or different, and each is independent of hydrogen, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Represents an alkyl or optionally substituted 4- to 15-membered heterocycline; R ４１ｃ Represents N or CH; (R ４１ｄ ) ｐ４１ａ The benzene ring connected to it is arbitrarily p41a R ４１ｄ This indicates that it is replaced by each R ４１ｄ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p41a represents an integer of 0, 1, 2, 3, or 4; (R) in equation (PBM-42) ４２ａ ) ｐ４２ａ The benzene ring connected to it is arbitrarily p42a R ４２ａ This indicates that it is replaced by each R ４２ａ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p42a represents an integer of 0, 1, 2, 3, 4, or 5; R ４２ｂ O, S, C １－３ Alkylene or halogenated carbon １－３ Represents alkylene; (R ４２ｃ ) ｐ４２ｂ The benzene ring connected to it is arbitrarily p42b R ４２ｃ This indicates that it is replaced by each R ４２ｃ These are the same or different, and each independently of the hydroxy, amino, cyano, halogen, and C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; p42b represents an integer of 0, 1, 2, 3, or 4; In formula (PBM-43), ring H is C ６－１５ (R) represents arylene or 5-15 member monocyclic, bicyclic or polycyclic heteroarylene. ４３ａ ) ｐ４３ａ The ring H has p43a R ４３ａ This indicates that it is replaced by and each R ４３ａ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It is an alkoxy; p43a represents an integer of 0, 1, 2, 3, or 4; R ４３ｂ This represents a 5-20 membered monocyclic, dicyclic, or polycyclic heteroaryl containing 1-4 heteroatoms selected from the group consisting of N, O, and S, which may optionally be hydroxyl, amino, cyano, halogen, nitro, or C. １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkyl or halogenated C １－６ Substituting with substituents selected from the group consisting of alkyl groups; R in equation (PBM-44) ４４ａ , R ４４ｂ , R ４４ｃ Each of these independently represents CH or N; R ４４ｄ is -C(O)NHR ４４ｈ ,-NHC(O)R ４４ｈ , -S(O) ２ NHR ４４ｈ , -NHS(O) ２ R ４４ｈ , -S(O) ２ R ４４ｈ or -P(O)(R ４４ｈ ) ２ This represents, where each R ４４ｈ They are the same or different, and each is independent of the others, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; (R ４４ｅ ) ｐ４４ａ p44a substituents R ４４ｅ This represents each R ４４ｅ These are the same or different, and each is independently a halogen, hydroxyl, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents alkoxy; p44a represents an integer of 0, 1, 2, 3, or 4; (R ４４ｆ ) ｐ４４ｂ p44b substituents R ４４ｆ This represents each R ４４ｆ These are the same or different, and each is independently a halogen, hydroxyl, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents alkoxy; p44b represents an integer of 0, 1, or 2; (R ４４ｇ ) ｐ４４ｃ The benzene ring connected to it is arbitrarily p44c R ４４ｇ This indicates that it is replaced by and each R ４４ｇ These are, independently, halogen, hydroxy, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents alkoxy; p44c represents an integer of 0, 1, 2, 3, or 4; R in formula (PBM-45) ｘ１ represents a bond, or C(O), or R ｘ１is -C(O)NH-R ｘ２ -C(O)-*** represents R, where the sign *** is R ｃ This represents the connection point with R ｘ２ is an arbitrarily substituted C ３－１５ Represents a cycloalkyl group; (R ４５ａ ) ｐ４５ａ The 1H-pyrrolo[2,3-b]pyridine ring connected to it has an arbitrary number of p45a R ４５ａ This indicates that it is replaced by and each R ４５ａ These are independently cyano, halogen, hydroxy, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It is an alkoxy, and p45a represents an integer of 0, 1, 2, 3, 4, or 5; (R ４５ｂ ) ｐ４５ｂ The pyridine ring connected to it has an arbitrary number of p45b R ４５ｂ This indicates that it is replaced by and each R ４５ｂ These are independently cyano, halogen, hydroxy, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Alkoxy or NR ４５ｃ R ４５ｄ And here R ４５ｃ , R ４５ｄ They are the same or different, and each is independent of hydrogen, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, optionally substituted C ３－１５ P45b represents a cycloalkyl group or an optionally substituted 4- to 15-membered heterocycline, and p45b represents an integer of 0, 1, 2, or 3; R in equation (PBM-46) ４６ａ is NHC(O), C(O)NH, NHS(O) ２ or S(O) ２Represents NH; (R ４６ｂ ) ｐ４６ａ The benzene ring connected to it is arbitrarily p46a R ４６ｂ This indicates that it is replaced by and each R ４６ｂ These are, independently, halogen, hydroxy, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ It is an alkoxy, and p46a represents an integer of 0, 1, 2, 3, 4, or 5; (R ４６ｃ ) ｐ４６ｂ The 1H-pyrazole ring connected to it is arbitrarily p46b R ４６ｃ This indicates that it is replaced by and each R ４６ｃ These are, independently, halogen, hydroxy, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ It is an alkoxy, and p46b represents an integer of 0, 1, or 2; R in equation (PBM-47) ４７ａ represents N or CH, and R ４７ｂ O, S, NH, CH ２ CH(F) or C(F) ２ It represents; R ４７ｃ represents a bond or optionally substituted methylene (e.g., a halogen-substituted methylene); Ring I is C ６－１５ (R) represents an aryl, a 4- to 15-membered heterocyclyl, or a 5- to 15-membered heteroaryl. ４７ｄ ) ｐ４７ａ The ring I connected to it has an arbitrary number of p47a R ４７ｄ This indicates that it is replaced by and each R ４７ｄ They are the same or different, and each independently, a deuterium, halogen, hydroxyl, cyano, amino, nitro, oxo group, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It is an alkoxy, and p47a represents an integer of 0, 1, 2, 3, or 4; (R ４７ｅ ) ｐ４７ｂ R connected to it ４７ａ A 6-membered nitrogen-containing heteroaromatic ring containing any p47b R ４７ｅ This indicates that it is replaced by each R ４７ｅ Each of these is independently deuterium, halogen, hydroxyl, cyano, amino, nitro, and C. １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ It represents an alkyl group, and p47b represents an integer of 0, 1, or 2; (R ４７ｆ ) ｐ４７ｃ The benzene ring connected to it is arbitrarily p47c R ４７ｆ This indicates that it is replaced by each R ４７ｆ They are the same or different, and each independently, deuterium, halogen, hydroxyl, cyano, amino, nitro, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ It represents an alkyl group, and p47c represents an integer of 0, 1, 2, 3, or 4; R in equation (PBM-48) ４８ａ , R ４８ｂ and R ４８ｃ Each of these independently represents either N or CH; (R ４８ｄ ) ｐ４８ａ The naphthyl connected to it has an arbitrary number of p48a R ４８ｄ This indicates that it is replaced by each R ４８ｄ These are, independently, halogen, hydroxy, amino, mercapto, nitro, cyano, and C. ２－６ Alkinyl, C ２－６ Alkenil, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ It represents an alkyl group, and p48a represents an integer of 0, 1, 2, 3, 4, 5, 6, or 7; R ４８ｅ is an arbitrarily substituted C ３－１５ Represents a cycloalkyl or a 4- to 15-membered heterocycline containing 1-4 heteroatoms selected from the group consisting of optionally substituted N, O, and S; R ４８ｆ These are hydrogen, halogen, hydroxy, cyano, amino, mercapto, nitro, and C. ２－６ Alkinyl, C ２－６ Alkenil, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C １－６ Alkyl, deuterated C １－６ Alkyl or halogenated C １－６ Represents alkyl; R in equation (PBM-49) ４９ａ represents N or CH; R ４９ｂ is NHC(O), C(O)NH, NHS(O) ２ or S(O) ２ Represents NH; (R ４９ｃ ) ｐ４９ａ R connected to it ４９ａ A 6-membered ring containing p49a R ４９ｃ This indicates that it is replaced by each R ４９ｃ These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents an alkoxy, and p49a represents an integer of 0, 1, 2, 3, or 4; Ring J represents a 5-15 member heteroarylene, (R ４９ｄ ) ｐ４９ｂThe ring J connected to it has an arbitrary number of p49b R ４９ｄ This indicates that it is replaced by each R ４９ｄ These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, hydroxysubstituted C １－６ Alkyl, amino-substituted C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ alkoxy or optionally substituted C ３－１５ Represents a cycloalkyl group, and p49b represents an integer of 0, 1, 2, or 3; In formula (PBM-50), (R ５０ａ ) ｐ５０ａ The benzene ring connected to it has p50a R ５０ａ This indicates that it is replaced by each R ５０ａ These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkyl-S(O) ２ , halogenated C １－６ Alkyl-S(O) ２ , halogenated C １－６ Alkyl-NHC(O), halogenated C １－６ Alkyl-C(O)NH, C halogenated １－６ Alkyl-NHS(O) ２ , halogenated C １－６ Alkyl-S(O) ２ NH, C １－６ Alkoxy or C halogenated compounds １－６ It represents an alkoxy, and p50a represents an integer of 0, 1, 2, 3, or 4; R ５０ｂ is hydrogen, C １－６ Alkyl, halogenated C １－６ Alkyl or deuterated C １－６ Represents alkyl; (R) in formula (PBM-51) ５１ａ ) ｐ５１ａ The benzene ring connected to it has p51a R ５１ａ This indicates that it is replaced by each R ５１ａ These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ alkoxy, optionally substituted C ３－１５ Represents a cycloalkyl or a 4- to 15-membered heterocycline containing 1-4 heteroatoms selected from the group consisting of optionally substituted N, O, and S, and p51a represents an integer of 0, 1, 2, 3, 4, or 5; (R ５１ｂ ) ｐ５１ｂ The benzene ring connected to it is p51b R ５１ｂ This indicates that it is replaced by each R ５１ｂ These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ alkoxy, optionally substituted C ３－１５ Represents a cycloalkyl or a 4- to 15-membered heterocycline containing 1-4 heteroatoms selected from the group consisting of optionally substituted N, O, and S, and p51b represents an integer of 0, 1, 2, 3, or 4; (R ５１ｃ ) ｐ５１ｃ The isoxazole ring connected to it has any p51c R ５１ｃ This indicates that it is replaced by each R ５１ｃ These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ It represents an alkoxy, and p51c represents an integer of 0, 1, or 2; In equation (PBM-52), the dashed line indicates the presence of an arbitrary double bond; (R ５２ａ ) ｐ５２ａ The six-membered cycloalkyl group connected to it has an arbitrary number of p52a R ５２ａ This indicates that it is replaced by each R ５２ａ These are the same or different, and each independently, halogen, hydroxy, mercapto, cyano, amino, nitro, oxo group, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ Represents an alkoxy, and p52a represents an integer of 0, 1, 2, 3, 4, 5, 6, 7, or 8; (R ５２ｂ ) ｐ５２ｂ The benzene ring connected to it is arbitrarily p52b R ５２ｂ This indicates that it is replaced by each R ５２ｂ These are the same or different, and each independently, deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ It represents an alkoxy, and p52b represents an integer of 0, 1, 2, 3, 4, or 5; (R ５２ｃ ) ｐ５２ｃ The six-membered cycloalkyl group connected to it has an arbitrary number of p52c R ５２ｃ This indicates that it is replaced by each R ５２ｃ They are the same or different, and each independently, a halogen, cyano, oxo group, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６Represents an alkoxy, and p52c represents an integer of 0, 1, 2, 3, 4, 5, 6, 7, or 8; (R ５２ｄ ) ｐ５２ｄ The benzene ring connected to it is arbitrarily p52d R ５２ｄ This indicates that it is replaced by each R ５２ｄ These are the same or different, and each is independently a halogen, hydroxyl, mercapto, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy or [C26] This represents and p52d represents an integer of 0, 1, or 2; (R ５２ｅ ) ｐ５２ｅ The benzene ring connected to it is arbitrarily p52e R ５２ｅ This indicates that it is replaced by each R ５２ｅ These are the same or different, and each independently, deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, -SO ２ CF ３ , C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ It represents an alkoxy, and p52e represents an integer of 0, 1, 2, 3, or 4; R ５２ｆ Hydrogen, deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy or [C27] This represents , where y3 represents an integer of 1, 2, or 3; (R) in formula (PBM-53) ５３ａ ) ｐ５３ａ p53a substituents R ５３ａ This represents each R ５３ａ These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It represents an alkoxy, and p53a represents an integer of 0, 1, 2, 3, 4, or 5; (R ５３ｂ ) ｐ５３ｂ The benzene ring connected to it is arbitrarily p53b R ５３ｂ This indicates that it is replaced by each R ５３ｂ These are the same or different, and each independently, deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ Represents an alkoxy, and p53b represents an integer of 0, 1, 2, 3 or 4; and R ５３ｃ is C １－６ Alkylene or halogenated carbon １－６ Represents alkylene; (R) in formula (PBM-54) ５４ａ ) ｐ５４ａ p54a substituents R ５４ａ This represents each R ５４ａ These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ Represents an alkoxy, and p54a represents an integer of 0, 1, 2, 3, or 4; (R ５４ｂ ) ｐ５４ｂ The benzene ring connected to it is arbitrarily p54b R ５４ｂThis indicates that it is replaced by each R ５４ｂ These are the same or different, and each independently, deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ Represents an alkoxy, and p54b represents an integer of 0, 1, 2, 3, or 4; (R) in formula (PBM-55) ５５ａ ) ｐ５５ａ p55a substituents R ５５ａ This represents each R ５５ａ These are the same or different, and each independently of the others, halogen, hydroxy, mercapto, cyano, amino, nitro, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or C halogenated compounds １－６ It represents an alkoxy, and p55a represents an integer of 0, 1, 2, 3, or 4; R ５５ｂ , R ５５ｃ They are the same or different, and each is independent of hydrogen, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Represents an alkyl group or an optionally substituted aryl group; R in formula (PBM-55) ５５ｄ is a fragment [C28] or [C29] This represents the connection point with the ring-forming carbon atom, where the symbol ### represents the connection point with the ring-forming nitrogen atom, and R ５５ｅ represents an arbitrarily substituted aryl or an arbitrarily substituted heteroaryl, and R ５５ｆ is hydrogen, halogen, C １－６ Alkyl, halogenated C １－６ Alkyl or deuterated C １－６ Represents alkyl; and R in each general formula ｃ These are, independently, bonded, -O-, and -N(R). ｄ )-, -NHC(O)-*, -C(O)NH-*, -N(R ｄ )-R ｆ -N(R) ｅ ) - *, - R ｆ -C(O)NH-*, -R ｆ -NHC(O)-*, -R ｆ -C(O)O-*, -R ｆ -OC(O)-*, -C(O)O-*, -OC(O)-*, -R ｆ -, -R ｆ -N(R) ｄ )-*,-O-R ｆ -N(R) ｄ ) - *, [C30] [C31] [C32] [C33] [C34] [C35] [C36] [C37] [C38] [C39] [C40] [C41] [C42] [C43] [C44] [C45] [C46] , or [C47] It represents; In the formula, each ring W ２(R) are the same or different and each independently represents a nitrogen-containing heterocyclylene, t1 represents an integer of 1 or 2, ｃ１ ) ｍ２ Each ring W ２ Each of them independently and arbitrarily has m2 R ｃ１ This indicates substitution by the group, and each R ｃ１ Deuterium and C are independent of each other. １－６ Alkyl and deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, C １－６ Alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxy, C ２－６ Alkinyl, C ２－６ Alkenyl, optionally deuterated C ３－６ Cycloalkyl, or R ｃ４ -R ｃ３ - and here R ｃ３ is an arbitrarily substituted C １－６ Alkylene or optionally substituted C ２－６ It is an alkenylene, R ｃ４ is halogen, R ｃ５ R ｃ６ N- represents hydroxy, carboxy, ethynyl, or vinyl, where R ｃ５ and R ｃ６ They are the same or different, and each is independently of hydrogen or C １－３ The integer part represents an alkyl group, and m² represents an integer between 0 and 20; Each ring W ３ (R) are the same or different and each independently represents a heterocyclylene, cycloalkylene, arylene, or heteroarylene, where t2 represents an integer of 0 or 1, ｃ２ ) ｍ３ Each ring W ３ These independently and arbitrarily have m3 R ｃ２ This indicates substitution by the group, and each R ｃ２ Deuterium and C are independent of each other. １－６ Alkyl and deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, C １－６ Alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxy, C ２－６ Alkinyl, C ２－６ Alkenyl, optionally deuterated C ３－６ Cycloalkyl, or R ｃ８ -R ｃ７ - and here R ｃ７ is an arbitrarily substituted C １－６ Alkylene or optionally substituted C ２－６ It is an alkenylene, R ｃ８ is halogen, R ｃ９ R ｃ１０ N- represents hydroxy, carboxy, ethynyl, or vinyl, where R ｃ９ and R ｃ１０ They are the same or different, and each is independently of hydrogen or C １－３ Alkyl represents, and m3 represents an integer from 0 to 20; and R ｄ and R ｅ Each of them independently consists of hydrogen or C １－６ R represents alkyl. ｆ and R ｇ Each of these is independently and arbitrarily substituted C １－６ Alkylene or optionally substituted C ２－６ A compound of formula (I) according to claim 1, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph thereof, wherein the symbol * represents an alkenylene and the symbol * represents a connection point with LIN.

4. The aforementioned PBM has the following structure: [C48] [C49] [50] [C51] [C52] [C53] [C54] [C55] [C56] [C57] [C58] [C59] [60] [61] [62] [63] [64] [65] [66] [67] [68] [69] [C70] [C71] [C72] [C73] [C74] [C75] [C76] [C77] It represents; In the formula, R ｃ The compound of formula (I) or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph described in claim 3, wherein is defined as in claim 3.

5. The aforementioned R ｃ represents a bond, -O-, -NHC(O)-*, -C(O)NH-*, -C(O)O-*, -OC(O)-*, or -NH-, or R ｃ The structure of the following expression is: -N(R) ｄ )-,-N(R ｄ )-R ｆ -N(R) ｅ ) - *, - R ｆ -C(O)NH-*, -R ｆ -NHC(O)-*, -R ｆ -C(O)O-*, -R ｆ -OC(O)-*,-R ｆ -, -R ｆ -N(R) ｄ )-*,-O-R ｆ -N(R) ｄ ) - *, [C30] [C31] [C32] [C33] [C34] [C35] [C36] [C37] [C38] [C39] [C40] [C41] [C42] [C43] [C44] [C45] [C46] , or [C47] It represents; In the formula, each ring W ２ (R) represents a 4-20 member nitrogen-containing heterocyclylene that is the same or different and independent of each other, where t1 represents an integer of 1 or 2, and (R) ｃ１ ) ｍ２ Each ring W ２ Each of them independently and arbitrarily has m2 R ｃ１ This indicates substitution by the group, and each R ｃ１ Deuterium and C are independent of each other. １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxy, C ２－６ Alkinyl, C ２－６ Alkenyl, optionally deuterated C ３－６ Cycloalkyl, or R ｃ４ -R ｃ３ - and here R ｃ３ is an arbitrarily substituted C １－６ Alkylene or optionally substituted C ２－６ It is an alkenylene, R ｃ４ is halogen, R ｃ５ R ｃ６ N- represents hydroxy, carboxy, ethynyl, or vinyl, where R ｃ５ and R ｃ６ They are the same or different, and each is independently of hydrogen or C １－３ The integer part represents an alkyl group, and m² represents an integer between 0 and 20; Each ring W ３ These are the same or different, and each is independently a 4-20 member nitrogen-containing heterocyclylene, C ３－２０ Cycloalkylene, C ６－２０ R represents arylene or 5-20 member heteroarylene, where t2 represents an integer of 0 or 1, (R ｃ２ ) ｍ３ Each ring W ３ These independently and arbitrarily have m3 R ｃ２ This indicates substitution by the group, and each R ｃ２ Deuterium and C are independent of each other. １－６ Alkyl and deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxy, C ２－６ Alkinyl, C ２－６ Alkenyl, optionally deuterated C ３－６ Cycloalkyl, or R ｃ８ -R ｃ７ - and here R ｃ７ is an arbitrarily substituted C １－６ Alkylene or optionally substituted C ２－６ It is an alkenylene, R ｃ８ is halogen, R ｃ９ R ｃ１０ N- represents hydroxy, carboxy, ethynyl, or vinyl, where R ｃ９ and R ｃ１０ They are the same or different, and each is independently of hydrogen or C １－３ Alkyl represents, and m3 represents an integer from 0 to 20; and R ｄ and R ｅ Each of them independently consists of hydrogen or C １－６ R represents alkyl. ｆ and R ｇ Each of these is an arbitrarily substituted C, independently of the others. １－６ Alkylene or optionally substituted C ２－６ Represents alkenylene; Said C １－６ Alkylene and C ２－６ Each alkenylene can independently be any deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, or C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ Substituted with one or more substituents selected from the group consisting of alkoxys; and The symbol * represents a connection point with LIN, and the compound of formula (I) or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analogue, pharmaceutical precursor, or polymorph described in claim 3.

6. Each ring W ２ These are the same or different, and each is independently a 4-15 member nitrogen-containing heterocyclylene, for example, Piperidinylene, piperidinylene, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidinylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanirene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene, azabicyclo[3.1.1]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo [2.2.2]octanylene, diazabicyclo[3.1.1]heptanylene, diazabicyclo[2.2.1]heptanylene, diazabicyclo[3.2.1]octanylene, diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecarnylene, 8-azaspiro[4.5]decanylene, 2-oxa-8-azaspiro[4.5]decanylene, or 3-methyl-2-oxa-8-azaspiro[4.5]decanylene, or [C78] [C79] [C80] [chemical 81] [chemical 82] [chemical 83] [chemical 84] It represents; Each ring W ２ Each of these independently has an arbitrary m² R ｃ１ This indicates substitution by the group, and each R ｃ１ Deuterium and C are independent of each other. １－６ Alkyl and deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxy, C ２－６ Alkinyl, C ２－６ Alkenyl, optionally deuterated C ３－６ Cycloalkyl, or R ｃ４ -R ｃ３- and here R ｃ３ is an arbitrarily substituted C １－６ Alkylene or optionally substituted C ２－６ It is an alkenylene, R ｃ４ is halogen, R ｃ５ R ｃ６ N- represents hydroxy, carboxy, ethynyl, or vinyl, where R ｃ５ and R ｃ６ They are the same or different, and each is independently of hydrogen or C １－３ Represents alkyl, and the C １－６ Alkylene and the C ２－６ Each alkenylene can independently be any deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, or C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ It is substituted with one or more substituents selected from the group consisting of alkoxys, and m2 represents an integer between 0 and 20; Each ring W ３ These are the same or different, and each is independently a 4-15 member nitrogen-containing heterocyclylene, C ３－１５ Cycloalkylenes, 6-15 membered arylenes, or 5-15 membered heteroarylenes, for example, Piperidinylene, piperazine, morpholinylene, azetidinylene, pyrrolidinylene, imidazolidylene, pyrazolidinylene, oxazolidinylene, thiazolidinylene, thiomorpholinylene, azepanirene, diazacycloheptanylene, azacyclooctylene, diazacyclooctylene, azabicyclo[3.1.1]heptanylene, azabicyclo[2.2.1]heptanylene, azabicyclo[3.2.1]octanylene, azabicyclo[2.2.2]octanylene, diazabicyclo[3.1.1]heptanylene, diazabicyclo[2.2.1]hept Nylene, diazabicyclo[3.2.1]octanylene, diazabicyclo[2.2.2]octanylene, 3-azaspiro[5.5]undecanylene, 8-azaspiro[4.5]decanylene, 2-oxa-8-azaspiro[4.5]decanylene, 3-methyl-2-oxa-8-azaspiro[4.5]decanylene, cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decalinylene, octahydrocyclopentarenylene, octahydro-1H-inde Nylene, 2,3-dihydro-1H-indenylene, spirocycloalkylene, adamantanylene, noradamantanylene, norbornylene, phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazoylene, thienylene, thiazoylene, isothiazoylene, thiadiazoylene, pyrrolylene, imidazoylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridadinylene, pyradinylene, pyradinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazoli Len, benzimidazolylene, benzoxazolylene, benzoisoxazolylene, benzothiazollylene, benzoisothiazollylene, benzotriazolylene, benzo[2,1,3]oxadiazollylene, benzo[2,1,3]thiadiazollylene, benzo[1,2,3]thiadiazollylene, quinolinylene, isoquinolinylene, naphthyridinylene, sinnorinylene, quinazolinylene, quinoxalinylene, phthalazine, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidinylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, pyrrolo[2,1-b]thiazoylene, or imidazo[2,1-b]thiazoylene, or [chemical 85] [chemical 86] [chemical 87] [C88] [chemical 89] [C90] [C91] It represents; Each ring W ３ These are independently and arbitrarily m3 R ｃ２ Substituted with each R ｃ２ Deuterium and C are independent of each other. １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxy, C ２－６ Alkinyl, C ２－６ Alkenyl, optionally deuterated C ３－６ Cycloalkyl, or R ｃ８ -R ｃ７ - and here R ｃ７ is an arbitrarily substituted C １－６ Alkylene or optionally substituted C ２－６ It is an alkenylene, R ｃ８ is halogen, R ｃ９ R ｃ１０ N- represents hydroxy, carboxy, ethynyl, or vinyl, where R ｃ９ and R ｃ１０ They are the same or different, and each is independently of hydrogen or C １－３ Represents alkyl, and the C １－６ Alkylene and the C ２－６Alkenylenes can be any and all independently of deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, or C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ A compound of formula (I) according to any one of claims 3 to 5, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph, wherein the compound is substituted with one or more substituents selected from the group consisting of alkoxys, and m3 represents an integer between 0 and 20.

7. R ｃ Parts in each general formula [C92] The following is the basis: [C93] [C94] [C95] [C96] [C97] [C98] [C99] [C100] [C101] [chemical 102] [chemical 103] [chemical 104] [C105] [C106] [C107] [C108] [C109] [C110] [C111] [C112] [C113] [C114] [C115] [C116] [C117] [C118] [C119] [C120] It represents; Here, each of the aforementioned groups may optionally be further composed of deuterium and deuterated C, independently of each other. １－６ Alkyl, optionally halogenated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, deuterated C １－６ Alkoxy, halogen, amino, hydroxy, mercapto, cyano, carboxy, C ２－６ Alkinyl, C ２－６ Alkenyl, optionally deuterated C ３－６ Cycloalkyl, R ｃ１２ -R ｃ１１ , or one or more substituents selected from the group consisting of any combination thereof, where R ｃ１１ is an arbitrarily substituted C １－６ Alkylene or optionally substituted C ２－６ It is an alkenylene, R ｃ１２ is halogen, R ｃ１３ R ｃ１４ N- represents hydroxy, carboxy, ethynyl, or vinyl, where R ｃ１３ and R ｃ１４ They are the same or different, and each is independently of hydrogen or C １－３ Represents alkyl, and the C １－６ Alkylene and C ２－６ Each alkenylene can be independently and optionally composed of deuterium, halogen, hydroxyl, mercapto, cyano, amino, nitro, or C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy or halogenated C １－６ A compound of formula (I) according to any one of claims 3 to 6, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph, which is substituted with one or more substituents selected from the group consisting of alkoxys.

8. The aforementioned R ｃ The following are the basis: Bond, -O-, -NHC(O)-*, -C(O)NH-*, -C(O)O-*, -OC(O)-*, -CH ２ C(O)O-*, -CH ２ OC(O)-*, -NH-, -N(CH ３ )-,-N(CH ３ )-(CH ２ ) ２ -N(CH ３ )-*,-N(CH ３ )-(CH ２ ) ３ -N(CH ３ )-*, -NH-(CH ２ ) ２ -N(CH ３ )-*,-N(CH ３ )-(CH ２ ) ３ -NH-*, -CH ２ -NHC(O)-*, -CH ２ -C(O)NH-*, -CH ２ -NH-*, -O-(CH ２ ) ２ -N(CH ３ )-*, -O-(CH ２ ) ２ -NH-*, or -CH ２ -N(CH ３ ) - *, or [C121] [C122] [C123] [C124] 【Chemistry 125】 【Chemistry 126】 【Chemistry 127】 【Chemistry 128】 【Chemistry 129】 【Chemistry 130】 【Chemistry 131】 【Chemistry 132】 【Chemistry 133】 【Chemistry 134】 【Chemistry 135】 【Transformation 136】 【Chemistry 137】 【Chemistry 138】 【Chemistry 139】 [Chemistry 140] 【Chemistry 141】 【Chemistry 142】 【Chemistry 143】 【Chemistry 144】 【Chemistry 145】 【Chemistry 146】 【Chemistry 147】 【Chemistry 148】 【Chemistry 149】 [Chemical 150] 【Chemistry 151】 【Chemistry 152】 【Chemistry 153】 【Chemistry 154】 [C155] [C156] [C157] [C158] [C159] [C160] [C161] [C162] [C163] [C164] [C165] [C166] [C167] [C168] [C169] [C170] It represents; Here, each of the aforementioned groups may independently be further optionally composed of deuterium, C １－６ Alkyl, deuterated C １－６ Alkyl, halogenated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ A compound of formula (I) according to any one of claims 3 to 6, or a salt, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph thereof, substituted with one or more substituents selected from the group consisting of alkoxy, halogen, amino, hydroxy, mercapto, cyano, or any combination thereof; and the symbol * represents a connection point with LIN.

9. (i) Ring W in the structure of formula (ULM) １ C ６－２０ Allirene, or a 5-20 member monocyclic, bicyclic, or polycyclic heteroarylene, the above C ６－２０Arylenes and 5-20 membered monocyclic, bicyclic, or polycyclic heteroarylenes each independently have any m identical or different R ａ５ Replaced by; preferably, the ring W １ There are arbitrarily m identical or different R ａ５ The following groups are substituted by: phenylene, naphthylene, furanylene, oxazolylene, isoxazolylene, oxadiazollylene, thienylene, thiazollylene, isothiazollylene, thiadiazollylene, pyrrolylene, imidazollylene, pyrazolylene, triazolylene, pyridylene, pyrimidinylene, pyridadinylene, pyradinylene, indolylene, isoindolylene, benzofuranylene, isobenzofuranylene, benzothienylene, indazolylene, benzimidazolylene, benzooxazolylene, benzoisoxazolylene, benzothiazollylene, benzoisothiazollylene, benzo Represents nzotriazoylene, benzo[2,1,3]oxadiazoylene, benzo[2,1,3]thiadiazoylene, benzo[1,2,3]thiadiazoylene, quinolinylene, isoquinolinylene, naphthyridylene, sinnorinylene, quinazolinylene, quinoxalinylene, phthalazine, pyrazolo[1,5-a]pyridylene, pyrazolo[1,5-a]pyrimidylene, imidazo[1,2-a]pyridylene, 1H-pyrrolo[3,2-b]pyridylene, 1H-pyrrolo[2,3-b]pyridylene, pyrrolo[2,1-b]thiazoylene, or imidazo[2,1-b]thiazoylene; Here are each R ａ５ These are, independently, halogen, hydroxy, mercapto, nitro, amino, cyano, and C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, deuterated C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ２－６ Alkenyl, or C ２－６ Represents an alkinyl; and m represents an integer of 0, 1, 2, 3, or 4; and / or (ii) In the structure of formula (ULM) above, X is a bond or -R ｂ１ -N(R) ａ６ )-R ｂ２ - represents, and here R ａ６ is hydrogen or C １－６ Represents alkyl, and R ｂ１ and R ｂ２ Each of these is an arbitrarily substituted C, independently of the others. ０－２ Represents alkylene, preferably the optionally substituted C. ０－２ The substituents on the alkylene can optionally be deuterium, halogen, hydroxyl, mercapto, nitro, amino, cyano, or C. １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, deuterated C １－６ Alkoxy, C halogenated １－６ A compound of formula (I) according to claim 1, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph, selected from the group consisting of alkoxys or any combination thereof.

10. The aforementioned ULM has the structure of the following formula (ULM-1) or formula (ULM-2): [C171] This represents, In the formula, A, R ａ１ , R ａ２ , R ａ３ , R ａ４ , (R ａ５ ) ｍ , R ａ６ , R ｂ１ , R ｂ２ and ring W １ The ULM is as defined in claim 1 or 9, and preferably the ULM has the following structure: [C172] [C173] [C174] [C175] [C176] [C177] [C178] [C179] [C180] [C181] A compound of formula (I) according to claim 1 or 9, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph representing the above.

11. The aforementioned LIN is, Independently, deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ３－６ Cycloalkyl, halogenated C ３－６ Cycloalkyl, deuterated C ３－６ Methylene compounds optionally substituted with one or two substituents selected from the group consisting of cycloalkyls, 4- to 10-membered heterocyclines, or any combination thereof; or A linear or branched C that has been arbitrarily substituted. ２－１５ This represents alkylene, where the C of the straight-chain or branched chain is... ２－１５ Between any pair or more adjacent carbon atoms in the alkylene carbon backbone, R ａ , R ｂ And one or more groups selected from the group consisting of any combination thereof are arbitrarily interposed, and each group R ａ These are independently O, C(O), OC(O), S, S(O), S(O) ２ , S(O) ２ N(R) ａ７ ), N (R ａ７ ) S(O) ２ , C(O)N(R ａ７ ), N (R ａ７ ) C(O), N(R ａ７ ) and N(R ａ７ ) C(O)N(R ａ７ A group consisting of ) is selected, where each R ａ７ Each is independently H or C １－３ Represents alkyl, and the linear or branched C ２－１５ The alkylene carbon backbone has two or more groups R ａ When intervening, each base R ａ They are not directly connected to each other; and each base R ｂ These are independently and arbitrarily substituted cycloalkylenes (e.g., arbitrarily substituted C ３－２０ Cycloalkylenes), optionally substituted arylenes (e.g., optionally substituted C ３－２０ Arylenes), optionally substituted heterocyclylenes (e.g., optionally substituted 4-20 member heterocyclylenes), optionally substituted heteroarylenes (e.g., optionally substituted 5-20 member heteroarylenes), alkynylenes (e.g., C ２－６ Alkynylenes), alkenylenes (for example, C ２－６ A group selected from alkenylenes and any combination thereof, where the cycloalkylene, arylene, heterocyclylene and heteroarylene each independently further comprises a deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, oxo group, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ３－６ Cycloalkyl, halogenated C ３－６ Cycloalkyl, deuterated C ３－６ The C of the linear or branched chain is optionally substituted with substituents selected from the group consisting of cycloalkyls, 4- to 10-membered heterocyclines, and any combination thereof, and where the C of the linear or branched chain is optionally substituted. ２－１５ One or more hydrogen atoms in an alkylene can further be deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, oxo groups, or halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ３－６ Cycloalkyl, halogenated C ３－６ Cycloalkyl, deuterated C ３－６A compound of formula (I) according to any one of claims 1 to 10, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph, which is optionally substituted with substituents selected from the group consisting of cycloalkyls, 4- to 10-membered heterocyclines, and any combination thereof.

12. The aforementioned LIN is, -C １－１５ Alkilen; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ - (R ａ (C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ - (R ａ (C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ - (R ａ (C(R ａ１２ ) (Caution ａ１３ )) ｎ３ ) ｍ２ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ - (R ａ (C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ - (R ａ (C(R ａ１２ ) (Caution ａ１３ )) ｎ３ ) ｍ２ - (R ａ (C(R ａ１４ ) (Caution ａ１５ )) ｎ４ ) ｍ３ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ - (R ｂ (C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(R ｂ (C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(R ｂ (C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ２ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(R ｂ (C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(R ｂ (C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ２ -(R ｂ (C(R ａ１４ )(R ａ１５ )) ｎ４ ) ｍ３ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(R ａ -R ｂ -(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(R ａ (C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(R ｂ (C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ２ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(R ｂ -R ａ - (C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -; or - (C(R ａ８ ) (Caution ａ９ )) ｎ１ - (R ｂ (C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ - (R ａ (C(R ａ１２ ) (Caution ａ１３ )) ｎ３ ) ｍ２ - represents; Here, each base R ａ These are independently O, C(O), OC(O), S, S(O), S(O) ２ , S(O) ２ N(R) ａ７ ), N (R ａ７ ) S(O) ２ , C(O)N(R ａ７ ), N (R ａ７ ) C(O), N(R ａ７ ) and N(R ａ７ ) C(O)N(R ａ７ A group consisting of ) is selected, where each R ａ７ Each is independently H or C １－３ Represents alkyl groups; each group R ｂ These are independently of any substituted cycloalkylenes (e.g., any substituted C ３－２０ Cycloalkylenes), optionally substituted arylenes (e.g., optionally substituted C ３－２０ Arylenes), optionally substituted heterocyclylenes (e.g., optionally substituted 4-20 member heterocyclylenes), optionally substituted heteroarylenes (e.g., 5-20 member heteroarylenes), alkynylenes (e.g., C ２－６ Alkynylenes), alkenylenes (for example, C ２－６A group selected from alkenylenes and any combination thereof, where the cycloalkylene, arylene, heterocyclylene and heteroarylene each independently further comprises a deuterium, hydroxy, amino, mercapto, nitro, halogen, cyano, oxo group, C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ３－６ Cycloalkyl, halogenated C ３－６ Cycloalkyl, deuterated C ３－６ Optionally substituted with substituents selected from the group consisting of cycloalkyls, 4- to 10-membered heterocyclines, and any combination thereof; R ａ８ , R ａ９ , R ａ１０ , R ａ１１ , R ａ１２ , R ａ１３ , R ａ１４ and R ａ１５ Each of these independently represents H, deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, oxo group, and halogenated C. １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ３－６ Cycloalkyl, halogenated C ３－６ Cycloalkyl, deuterated C ３－６ Represents cycloalkyls, 4- to 10-membered heterocyclines, and any combination thereof; and n1, n2, n3, n4, m1, m2, m3 are each independently selected from the group consisting of integers 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; and Said C １－１５ Any one or more hydrogen atoms in the alkylene may further be deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, oxo groups, or halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ３－６ Cycloalkyl, halogenated C ３－６ Cycloalkyl, deuterated C ３－６ A compound of formula (I) according to any one of claims 1 to 10, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph, which is optionally substituted with substituents selected from the group consisting of cycloalkyls, 4- to 10-membered heterocyclines, and any combination thereof.

13. The above LIN has the following structure: - (C(R ａ８ ) (Caution ａ９ )) ｎ１ - (O(C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ - (O(C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ - (O(C(R ａ１２ ) (Caution ａ１３ )) ｎ３ ) ｍ２ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ - (O(C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ - (O(C(R ａ１２ ) (Caution ａ１３ )) ｎ３ ) ｍ２ - (O(C(R ａ１４ ) (Caution ａ１５ )) ｎ４ ) ｍ３ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ - (N(R ａ７ ) (C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(N(R ａ７ )(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(N(R ａ７ )(C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ２ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(N(R ａ７ )(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(N(R ａ７ )(C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ２ -(N(R ａ７ )(C(R ａ１４ )(R ａ１５ )) ｎ４ ) ｍ３ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(C(O)N(R ａ７ )-(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(C(O)N(R ａ７ )-(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(C(O)N(R ａ７ )-(C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ２ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(C(O)N(R ａ７ )-(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(C(O)N(R ａ７ )-(C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ２ -(C(O)N(R ａ７ )-(C(R ａ１４ )(R ａ１５ )) ｎ４ ) ｍ３ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(C(O)N(R ａ７ )-(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(O-(C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ２ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -C(O)N(R ａ７ )-(C(R ａ１０ )(R ａ１１ )) ｎ２ -(O(C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ１ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(N(R ａ７ )C(O)-(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(N(R ａ７ )C(O)-(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(O-(C(R ａ１２ )(R ａ１３ ))) ｎ３ ) ｍ２ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(N(R ａ７ )C(O)-(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -(O-(C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ２ -(O-(C(R ａ１４ )(R ａ１５ )) ｎ４ ) ｍ３ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -N(R ａ７ )C(O)-(C(R ａ１０ )(R ａ１１ )) ｎ２ -(O(C(R ａ１２ )(R ａ１３ )) ｎ３ ) ｍ１ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -N(R ａ７ )C(O)N(R ａ７ )-(C(R ａ１０ )(R ａ１１ )) ｎ２ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -C(O)-(C(R ａ１０ )(R ａ１１ )) ｎ２ -; -(C(R ａ８ )(R ａ９ )) ｎ１ -(アリーレン-(C(R ａ１０ )(R ａ１１ )) ｎ２ ) ｍ１ -; -(C(R ａ８ )(R ａ９ )) ｎ１- (Arirene - (C (R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -Arirene- (C(R) ａ１２ ) (Caution ａ１３ )) ｎ３ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ -(heterocyclylene-(C(R) ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ -(heterocyclylene-(C(R) ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -(heterocyclylene-(C(R) ａ１２ ) (Caution ａ１３ )) ｎ３ ) ｍ２ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ -(heterorialene-(C(R) ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ -(heterorialene-(C(R) ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -(heterorialene-(C(R) ａ１２ ) (Caution ａ１３ )) ｎ３ ) ｍ２ -; - (C(R ａ８ ) (Caution ａ９ )) ｎ１ -(Cycloalkylene-(C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -; or - (C(R ａ８ ) (Caution ａ９ )) ｎ１ -(Cycloalkylene-(C(R ａ１０ ) (Caution ａ１１ )) ｎ２ ) ｍ１ -(Cycloalkylene-(C(R ａ１２ ) (Caution ａ１３ )) ｎ３ ) ｍ２ - represents; Here, each R ａ７ H or C １－３ Represents alkyl; The cycloalkylene (for example, C ３－２０ Cycloalkylene), the arylene (for example, C ３－２０ Arylene), the heterocyclylene (e.g., 4-20 membered heterocyclylene) and the heteroarylene (e.g., 5-20 membered heteroarylene) independently further contain deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, oxo groups, and C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ３－６ Cycloalkyl, halogenated C ３－６ Cycloalkyl, deuterated C ３－６ Optionally substituted with substituents selected from the group consisting of cycloalkyls, 4- to 10-membered heterocyclines, and any combination thereof; R ａ８ , R ａ９ , R ａ１０ , R ａ１１ , R ａ１２ , R ａ１３ , R ａ１４ and R ａ１５ These are, independently, H, deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, oxo group, and halogenated C. １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ３－６ Cycloalkyl, halogenated C ３－６Cycloalkyl, deuterated C ３－６ Represents cycloalkyls, 4- to 10-membered heterocyclines, and any combination thereof; and n1, n2, n3, n4, m1, m2, m3 are each independently selected from the group consisting of integers 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, and the compound of formula (I) or a salt, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph according to any one of claims 1 to 10.

14. LIN is based on the following: -CH ２ -, - (CH ２ ) ２ -, - (CH ２ ) ３ -, - (CH ２ ) ４ -, - (CH ２ ) ５ -, - (CH ２ ) ６ -, - (CH ２ ) ７ -, - (CH ２ ) ８ -, - (CH ２ ) ９ -, - (CH ２ ) １０ -, - (CH ２ ) １１ -, - (CH ２ ) １２ -, - (CH ２ ) １３ -, - (CH ２ ) １４ -, - (CH ２ ) １５ -;-CH ２ -O-CH ２ -ien-CH ２ -O-(CH ２ ) ２ -, - (CH ２ ) １ -O-(CH ２ ) ３ -, - (CH ２ ) １ -O-(CH ２ ) ４ -, - (CH ２ ) １ -O-(CH ２ ) ５ -、-(CH ２ ) １ -O-(CH ２ ) ６ -、-(CH ２ ) １ -O-(CH ２ ) ７ -、-(CH ２ ) １ -O-(CH ２ ) ８ -、-(CH ２ ) １ -O-(CH ２ ) ９ -、-(CH ２ ) １ -O-(CH ２ ) １０ -、-(CH ２ ) ２ -O-(CH ２ ) １ -、-(CH ２ ) ２ -O-(CH ２ ) ２ -、-(CH ２ ) ２ -O-(CH ２ ) ３ -、-(CH ２ ) ２ -O-(CH ２ ) ４ -、-(CH ２ ) ２ -O-(CH ２ ) ５ -、-(CH ２ ) ２ -O-(CH ２ ) ６ -、-(CH ２ ) ２ -O-(CH ２ ) ７ -、-(CH ２ ) ２ -O-(CH ２ ) ８ -、-(CH ２ ) ２ -O-(CH ２ ) ９ -、-(CH ２ ) ２-O-(CH ２ ) １０ -、-(CH ２ ) ３ -O-(CH ２ ) １ -、-(CH ２ ) ３ -O-(CH ２ ) ２ -、-(CH ２ ) ３ -O-(CH ２ ) ３ -、-(CH ２ ) ３ -O-(CH ２ ) ４ -、-(CH ２ ) ３ -O-(CH ２ ) ５ -、-(CH ２ ) ３ -O-(CH ２ ) ６ -、-(CH ２ ) ３ -O-(CH ２ ) ７ -、-(CH ２ ) ４ -O-(CH ２ ) １ -、-(CH ２ ) ４ -O-(CH ２ ) ２ -、-(CH ２ ) ４ -O-(CH ２ ) ３ -、-(CH ２ ) ４ -O-(CH ２ ) ４ -、-(CH ２ ) ４ -O-(CH ２ ) ５ -、-(CH ２ ) ４ -O-(CH ２ ) ６ -、-(CH ２ ) ５ -O-(CH ２ ) １ -、-(CH ２ ) ５ -O-(CH ２ ) ２ -、-(CH ２ ) ５ -O-(CH ２ ) ３ -、-(CH ２ ) ５ -O-(CH ２ ) ４ -、-(CH ２ ) ５ -O-(CH ２ ) ５ -、-(CH ２ ) ６ -O-(CH ２ ) １ -、-(CH ２ ) ６ -O-(CH ２ ) ２ -、-(CH ２ ) ６ -O-(CH ２ ) ３ -、-(CH ２ ) ６ -O-(CH ２ ) ４ -、-(CH ２ ) ７ -O-(CH ２ ) １ -、-(CH ２ ) ７ -O-(CH ２ ) ２ -、-(CH ２ ) ７ -O-(CH ２ ) ３ -、-(CH ２ ) ８ -O-(CH ２ ) １ -、-(CH ２ ) ８ -O-(CH ２ ) ２ -、-CH(CH ３ )-O-(CH ２ ) １ -、-CH(CH ３ )-O-(CH ２ ) ２ -、-CH(CH ３ )-O-(CH ２ ) ３ -、-CH(CH ３)-O-(CH ２ ) ４ -、-CH(CH ３ )-O-(CH ２ ) ５ -、-CH(CH ３ )-O-(CH ２ ) ６ -、-CH(CH ３ )-O-(CH ２ ) ７ -、-CH(CH ３ )-O-(CH ２ ) ８ -、-CH(CH ３ )-O-(CH ２ ) ９ -、-CH(CH ３ )-O-(CH ２ ) １０ -CH ２ -(O(CH ２ ) ２ ) ２ -CH ２ -(O(CH ２ ) ２ ) ３ -CH ２ -(O(CH ２ ) ２ ) ４ -CH ２ -(O(CH ２ ) ２ ) ５ -CH ２ -(O(CH ２ ) ２ ) ６ -CH ２ -(O(CH ２ ) ２ ) ７ -CH ２ -(O(CH ２ ) ２ ) １ -OCH ２ -CH ２ -(O(CH ２ ) ２ ) ２ -OCH ２ -CH ２ -(O(CH ２ ) ２ ) ３ -OCH ２-CH ２ -(O(CH ２ ) ２ ) ４ -OCH ２ -CH ２ -(O(CH ２ ) ２ ) ５ -OCH ２ -CH ２ -(O(CH ２ ) ２ ) ６ -OCH ２ -CH ２ -(O(CH ２ ) ２ ) ７ -OCH ２ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ２ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ３ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ４ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ５ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ６ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ７ -、-(CH ２ ) ３ -(O(CH ２ ) ２ ) ２ -、-(CH ２ ) ３ -(O(CH ２ ) ２ ) ３ -、-(CH ２ ) ３-(O(CH ２ ) ２ ) ４ -、-(CH ２ ) ３ -(O(CH ２ ) ２ ) ５ -、-(CH ２ ) ３ -(O(CH ２ ) ２ ) ６ -、-(CH ２ ) ３ -(O(CH ２ ) ２ ) ７ -、-(CH ２ ) ４ -(O(CH ２ ) ２ ) ２ -、-(CH ２ ) ４ -(O(CH ２ ) ２ ) ３ -、-(CH ２ ) ４ -(O(CH ２ ) ２ ) ４ -、-(CH ２ ) ４ -(O(CH ２ ) ２ ) ５ -、-(CH ２ ) ４ -(O(CH ２ ) ２ ) ６ -、-(CH ２ ) ４ -(O(CH ２ ) ２ ) ７ -CH ２ -(O(CH ２ ) ３ ) ２ -CH ２ -(O(CH ２ ) ３ ) ３ -CH ２ -(O(CH ２ ) ３ ) ４ -、-(CH ２ ) ２ -(O(CH ２ ) ３ ) ２ -、-(CH ２ ) ２ -(O(CH ２ ) ３ ) ３ -、-(CH ２ ) ２ -(O(CH ２ ) ３ ) ４ -、-(CH ２ ) ３ -(O(CH ２ ) ３ ) ２ -、-(CH ２ ) ３ -(O(CH ２ ) ３ ) ３ -、-(CH ２ ) ３ -(O(CH ２ ) ３ ) ４ -CH ２ -O-(CH ２ ) ２ -O-(CH ２ ) ３ -CH ２ -(O(CH ２ ) ２ ) ２ -(O(CH ２ ) ３ ) ２ -CH ２ -(O(CH ２ ) ２ ) ３ -(O(CH ２ ) ３ ) ３ -CH ２ -(O(CH ２ ) ２ ) ４ -(O(CH ２ ) ３ ) ４ - (CH) ２ ) ２ -O-(CH ２ ) ２ -O-(CH ２ ) ３ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ２ -(O(CH ２ ) ３ ) ２ -、-(CH ２ ) ３ -O-(CH ２ ) ２ -O-(CH ２ ) ３ -、-(CH ２ ) ３ -(O(CH ２ ) ２ ) ２ -(O(CH ２ ) ３ ) ２ -CH ２ -O-(CH ２ ) ３ -O-(CH ２ ) ２ -CH ２ -(O(CH ２ ) ３ ) ２ -(O(CH ２ ) ２ ) ２ -、-(CH ２ ) ２ -O-(CH ２ ) ３ -O-(CH ２ ) ２ -、-(CH ２ ) ２ -(O(CH ２ ) ３ ) ２ -(O(CH ２ ) ２ ) ２ - 、-(CH ２ ) ３ -O-(CH ２ ) ３ -O-(CH ２ ) ２ -、-(CH ２ ) ３ -(O(CH ２ ) ３ ) ２ -(O(CH ２ ) ２ ) ２ -CH ２ -O-(CH ２ ) ２ -O-CH ２ -、-(CH ２ ) ２ -O-(CH ２ ) ２ -O-CH ２ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ２ -O-(CH ２ ) ３ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ３ -O-(CH ２ ) ３ -、-(CH ２ ) ２ -(O(CH ２ ) ２ ) ４ -O-(CH ２ ) ３ -、-(CH ２ ) ５ -(O(CH ２ ) ２ ) ２ -O-(CH ２ ) ５ -、-(CH ２ ) ５ -(O(CH ２ ) ２ ) ２ -O-(CH ２ ) ６ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) １ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) ２ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) ３ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) ４ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) ５ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) ６ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) ７ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) ８ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) ９ -、-(CH ２ ) １ -N(R ａ７ )-(CH ２ ) １０ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) １ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) ２ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) ３ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) ４ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) ５ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) ６ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) ７ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) ８ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) ９ -、-(CH ２ ) ２ -N(R ａ７ )-(CH ２ ) １０ -、-(CH ２ ) ３ -N(R ａ７ )-(CH ２ ) １ -、-(CH ２ ) ３ -N(R ａ７ )-(CH ２ ) ２ -、-(CH ２ ) ３ -N(R ａ７ )-(CH ２ ) ３ -、-(CH ２ ) ４ -N(R ａ７ )-(CH ２ ) １ -、-(CH ２ ) ４ -N(R ａ７ )-(CH ２ ) ２ -、-(CH ２ ) ４ -N(R ａ７ )-(CH ２ ) ３ -、-(CH ２ ) ４ -N(R ａ７ )-(CH ２ ) ４ -、-(CH ２ ) ５ -N(R ａ７ )-(CH ２ ) １ -、-(CH ２ ) ５ -N(R ａ７ )-(CH ２ ) ２ -、-(CH ２ ) ５ -N(R ａ７ )-(CH ２ ) ３ -、-(CH ２ ) ５ -N(R ａ７ )-(CH ２ ) ４ -、-(CH ２ ) ５ -N(R ａ７ )-(CH ２ ) ５ -、-(CH ２ ) ６ -N(R ａ７ )-(CH ２ ) １ -、-(CH ２ ) ６ -N(R ａ７ )-(CH ２ ) ２ -、-(CH ２ ) ６ -N(R ａ７ )-(CH ２ ) ３ -、-(CH ２ ) ７ -N(R ａ７ )-(CH ２ ) １ -、-(CH ２ ) ７ -N(R ａ７ )-(CH ２ ) ２ -、-(CH ２ ) ７ -N(R ａ７ )-(CH ２ ) ３ -、-(CH ２ ) ８ -N(R ａ７ )-(CH ２ ) １ -、-(CH ２ ) ８ -N(R ａ７ )-(CH ２ ) ２ -、-(CH ２ ) ８ -N(R ａ７ )-(CH ２ ) ３ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) １ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) ２ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) ３ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) ４ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) ５ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) ６ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) ７ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) ８ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) ９ -、-CH(CH ３ )-N(R ａ７ )-(CH ２ ) １０ -、-CH ２ C(O)NHCH ２ -、-(CH ２ ) ２ C(O)NH(CH ２ ) ２ -、-(CH ２ ) ２ C(O)NH(CH ２ ) ３ -、-(CH ２ ) ２ C(O)NH(CH ２) ４ -、-(CH ２ ) ２ C(O)NH(CH ２ ) ５ -、-(CH ２ ) ３ C(O)NH(CH ２ ) ３ -、-(CH ２ ) ３ C(O)NH(CH ２ ) ４ -、-(CH ２ ) ４ C(O)NH(CH ２ ) ４ -、-(CH ２ ) ５ C(O)NH(CH ２ ) ５ -、-(CH ２ ) ６ C(O)NH(CH ２ ) ７ -、-(CH ２ ) ６ C(O)NH(CH ２ ) ６ -、-(CH ２ ) ７ C(O)NH(CH ２ ) ７ -、-(CH ２ ) ２ C(O)NH(CH ２ ) ２ -O-(CH ２ ) ２ -CH ２ NHC(O)CH ２ -、-(CH ２ ) ２ NHC(O)(CH ２ ) ２ -、-(CH ２ ) ２ NHC(O)(CH ２ ) ３ -、-(CH ２ ) ２ NHC(O)(CH ２ ) ４ -、-(CH ２ ) ２ NHC(O)(CH ２ ) ５ -、-(CH ２) ３ NHC(O)(CH ２ ) ３ -, - (CH ２ ) ３ NHC(O)(CH ２ ) ４ -, - (CH ２ ) ４ NHC(O)(CH ２ ) ４ -, - (CH ２ ) ５ NHC(O)(CH ２ ) ５ -, - (CH ２ ) ６ NHC(O)(CH ２ ) ７ -, - (CH ２ ) ６ NHC(O)(CH ２ ) ６ -, - (CH ２ ) ７ NHC(O)(CH ２ ) ７ -, - (CH ２ ) ４ NHC(O)(CH ２ ) ８ -, - (CH ２ ) ２ NHC(O)(CH ２ ) ２ -O-(CH ２ ) ２ -, - (CH ２ ) ４ NHC(O)CH ２ -ien-CH ２ -Phenylene-CH ２ -ien-CH ２ -Phenylene-(CH ２ ) ２ -ien-CH ２ -Phenylene-(CH ２ ) ３ -ien-CH ２ -Phenylene-(CH ２ ) ４ -ien-CH ２ -Phenylene-(CH ２ ) ５ -ien-CH ２ -Phenylene-(CH ２ ) ６ -ien-CH ２ -Phenylene-(CH ２ ) ７ -ien-CH ２ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ２ -Phenylene-(CH ２ ) １ -, - (CH ２ ) ２ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ２ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ２ -Phenylene-(CH ２ ) ４ -, - (CH ２ ) ２ -Phenylene-(CH ２ ) ５ -, - (CH ２ ) ２ -Phenylene-(CH ２ ) ６ -, - (CH ２ ) ２ -Phenylene-(CH ２ ) ７ -, - (CH ２ ) ２ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ３ -Phenylene-CH ２ -, - (CH ２ ) ３ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ３ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ３ -Phenylene-(CH ２ ) ４ -, - (CH ２ ) ３ - Phenyle Hmm (CH ２ ) ５ -, - (CH ２ ) ３ -Phenylene-(CH ２ ) ６ -, - (CH ２ ) ３ -Phenylene-(CH ２ ) ７ -, - (CH ２ ) ３ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ４ -Phenylene-CH ２ -, - (CH ２ ) ４ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ４ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ４ -Phenylene-(CH ２ ) ４ -, - (CH ２ ) ４ -Phenylene-(CH ２ ) ５ -, - (CH ２ ) ４ -Phenylene-(CH ２ ) ６ -, - (CH ２ ) ４ -Phenylene-(CH ２ ) ７ -, - (CH ２ ) ４ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ５ -Phenylene-(CH ２ ) １ -, - (CH ２ ) ５ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ５ -Phenylene-(CH ２ ) ３-, - (CH ２ ) ５ -Phenylene-(CH ２ ) ４ -, - (CH ２ ) ５ -Phenylene-(CH ２ ) ５ -, - (CH ２ ) ５ -Phenylene-(CH ２ ) ６ -, - (CH ２ ) ５ -Phenylene-(CH ２ ) ７ -, - (CH ２ ) ５ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ６ -Phenylene-(CH ２ ) １ -, - (CH ２ ) ６ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ６ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ６ -Phenylene-(CH ２ ) ４ -, - (CH ２ ) ６ -Phenylene-(CH ２ ) ５ -, - (CH ２ ) ６ -Phenylene-(CH ２ ) ６ -, - (CH ２ ) ６ -Phenylene-(CH ２ ) ７ -, - (CH ２ ) ６ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ７ -Phenylene-(CH ２ ) １ -, - (CH ２ ) ７ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ７ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ７ -Phenylene-(CH ２ ) ４ -, - (CH ２ ) ７ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ８ -Phenylene-CH ２ -, - (CH ２ ) ８ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ８ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ８ -Phenylene-(CH ２ ) ４ -, - (CH ２ ) ８ -Phenylene-(CH ２ ) ５ -, - (CH ２ ) ８ -Phenylene-(CH ２ ) ６ -, - (CH ２ ) ８ -Phenylene-(CH ２ ) ７ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Phenylene-CH ２ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ２ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ３ -ien-CH ２-N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ４ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ５ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ６ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ７ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ８ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Phenylene-CH ２ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Phenylene-(CH ２ ) ２ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Phenylene-(CH ２ ) ３ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Phenylene-(CH ２ ) ４ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Phenylene-(CH ２ ) ５ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２-Phenylene-(CH ２ ) ６ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Phenylene-(CH ２ ) ７ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Phenylene-CH ２ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ４ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ５ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ６ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ７ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ３ -N(R) ａ７ ) - CH ２ -Phenylene-CH ２ -, - (CH ２ ) ３ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ３ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ３ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ４ -N(R) ａ７ ) - CH ２ -Phenylene-CH ２ -, - (CH ２ ) ４ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ４ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ４ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ５ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ５ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ６ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ６ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ８ -, - (CH ２ ) ７ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Phenylene-CH ２ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ２ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ３ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ４ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ５ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Phenylene-(CH ２ ) ６-ien-CH ２ -Piperidinylene-CH ２ -ien-CH ２ -Piperidinylene-(CH ２ ) ２ -ien-CH ２ -Piperidinylene-(CH ２ ) ３ -ien-CH ２ -Piperidinylene-(CH ２ ) ４ -ien-CH ２ -Piperidinylene-(CH ２ ) ５ -ien-CH ２ -Piperidinylene-(CH ２ ) ６ -ien-CH ２ -Piperidinylene-(CH ２ ) ７ -ien-CH ２ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ２ -Piperidinylene-(CH ２ ) １ -, - (CH ２ ) ２ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ２ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ２ -Piperidinylene-(CH ２ ) ４ -, - (CH ２ ) ２ -Piperidinylene-(CH ２ ) ５ -, - (CH ２ ) ２ -Piperidinylene-(CH ２ ) ６ -, - (CH ２ ) ２ -Piperidinylene-(CH ２ ) ７ -, - (CH ２ ) ２ -Piperidinylene-(CH ２) ８ -, - (CH ２ ) ３ - Piperi Dinylene-CH ２ -, - (CH ２ ) ３ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ３ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ３ -Piperidinylene-(CH ２ ) ４ -, - (CH ２ ) ３ -Piperidinylene-(CH ２ ) ５ -, - (CH ２ ) ３ -Piperidinylene-(CH ２ ) ６ -, - (CH ２ ) ３ -Piperidinylene-(CH ２ ) ７ -, - (CH ２ ) ３ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ４ -Piperidinylene-CH ２ -, - (CH ２ ) ４ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ４ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ４ -Piperidinylene-(CH ２ ) ４ -, - (CH ２ ) ４ -Piperidinylene-(CH ２ ) ５ -, - (CH ２ ) ４ -Piperidinylene-(CH ２ ) ６ -, - (CH ２ ) ４ -Piperidinylene-(CH ２ ) ７ -, - (CH ２ ) ４ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ５ -Piperidinylene-(CH ２ ) １ -, - (CH ２ ) ５ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ５ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ５ -Piperidinylene-(CH ２ ) ４ -, - (CH ２ ) ５ -Piperidinylene-(CH ２ ) ５ -, - (CH ２ ) ５ -Piperidinylene-(CH ２ ) ６ -, - (CH ２ ) ５ -Piperidinylene-(CH ２ ) ７ -, - (CH ２ ) ５ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ６ -Piperidinylene-(CH ２ ) １ -, - (CH ２ ) ６ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ６ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ６ -Piperidinylene-(CH ２ ) ４ -, - (CH ２ ) ６ -Piperidinylene-(CH ２ ) ５ -, - (CH ２ ) ６ -Piperidinylene-(CH ２ ) ６ -, - (CH ２ ) ６ -Piperidinylene-(CH ２ ) ７ -, - (CH ２ ) ６ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ７ -Piperidinylene-(CH ２ ) １ -, - (CH ２ ) ７ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ７ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ７ -Piperidinylene-(CH ２ ) ４ -, - (CH ２ ) ７ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ８ -Piperidinylene-CH ２ -, - (CH ２ ) ８ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ８ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ８ -Piperidinylene-(CH ２ ) ４ -, - (CH ２ ) ８ -Piperidinylene-(CH ２ ) ５ -, - (CH ２ ) ８ -Piperidinylene-(CH ２ ) ６ -, - (CH ２ ) ８ -Piperidinylene-(CH ２ ) ７ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-CH ２ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ２ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ３ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ４ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ５ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ６ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ７ -ien-CH ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ８ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Piperidinylene-CH ２ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Piperidinylene-(CH ２ ) ２ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Piperidinylene-(CH ２ ) ３ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Piperidinylene-(CH ２ ) ４ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Piperidinylene-(CH ２ ) ５ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Piperidinylene-(CH ２ ) ６ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Piperidinylene-(CH ２ ) ７ -ien-CH ２ -N(R) ａ７ )-(CH ２ ) ２ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-CH ２ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ４ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ５ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ６ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ７ -, - (CH ２ ) ２ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ３ -N(R) ａ７ ) - CH ２ -Piperidinylene-CH ２ -, - (CH ２ ) ３ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ３ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ３ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ４ -N(R) ａ７ ) - CH ２ -Piperidinylene-CH ２ -, - (CH ２ ) ４ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ４ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ４ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ５ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ５ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ６ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ６ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ８ -, - (CH ２ ) ７ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Piperidinylene-CH ２ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ２ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ３ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ４ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ５ -, - (CH ２ ) ８ -N(R) ａ７ ) - CH ２ -Piperidinylene-(CH ２ ) ６ -ien-CH ２ -Piperadinylen-CH ２ -ien-CH ２ -Piperadinylen-(CH ２ ) ２ -ien-CH ２ -Piperadinylen-(CH ２ ) ３ -ien-CH ２ -Piperadinylen-(CH ２ ) ４ -ien-CH ２ -Piperadinylen-(CH ２ ) ５ -ien-CH ２ -Piperadinylen-(CH ２ ) ６ -ien-CH ２ -Piperadinylen-(CH ２ ) ７ -ien-CH ２ -Piperadinylen-(CH ２ ) ８ -, - (CH ２ ) ２-Piperadinylen-(CH ２ ) １ -, -( CH ２ ) ２ -Piperadinylen-(CH ２ ) ２ -, - (CH ２ ) ２ -Piperadinylen-(CH ２ ) ３ -, - (CH ２ ) ２ -Piperadinylen-(CH ２ ) ４ -, - (CH ２ ) ２ -Piperadinylen-(CH ２ ) ５ -, - (CH ２ ) ２ -Piperadinylen-(CH ２ ) ６ -, - (CH ２ ) ２ -Piperadinylen-(CH ２ ) ７ -, - (CH ２ ) ２ -Piperadinylen-(CH ２ ) ８ -, - (CH ２ ) ３ -Piperadinylen-CH ２ -, - (CH ２ ) ３ -Piperadinylen-(CH ２ ) ２ -, - (CH ２ ) ３ -Piperadinylen-(CH ２ ) ３ -, - (CH ２ ) ３ -Piperadinylen-(CH ２ ) ４ -, - (CH ２ ) ３ -Piperadinylen-(CH ２ ) ５ -, - (CH ２ ) ３ -Piperadinylen-(CH ２ ) ６ -, - (CH ２ ) ３ -Piperadinylen-(CH ２ ) ７ -, - (CH ２ ) ３ -Piperadinylen-(CH ２ ) ８ -, - (CH ２ ) ４ -Piperadinylen-CH ２ -, - (CH ２ ) ４ -Piperadinylen-(CH ２ ) ２ -, - (CH ２ ) ４ -Piperadinylen-(CH ２ ) ３ -, - (CH ２ ) ４ -Piperadinylen-(CH ２ ) ４ -, - (CH ２ ) ４ -Piperadinylen-(CH ２ ) ５ -, - (CH ２ ) ４ -Piperadinylen-(CH ２ ) ６ -, - (CH ２ ) ４ -Piperadinylen-(CH ２ ) ７ -, - (CH ２ ) ４ -Piperadinylen-(CH ２ ) ８ -, - (CH ２ ) ５ -Piperadinylen-(CH ２ ) １ -, - (CH ２ ) ５ -Piperadinylen-(CH ２ ) ２ -, - (CH ２ ) ５ -Piperadinylen-(CH ２ ) ３ -, - (CH ２ ) ５ -Piperadinylen-(CH ２ ) ４ -, - (CH ２ ) ５ -Piperadinylen-(CH ２ ) ５ -, - (CH ２ ) ５ -Piperadinylen-(CH ２ ) ６ -, - (CH ２ ) ５ -Piperadinylen-(CH ２ ) ７ -, - (CH ２ ) ５ -Piperadinylen-(CH ２ ) ８ -, - (CH ２ ) ６ -Piperadinylen-(CH ２ ) １ -, - (CH ２ ) ６ -Piperadinylen-(CH ２ ) ２ -, - (CH ２ ) ６ -Piperadinylen-(CH ２ ) ３ -, - (CH ２ ) ６ -Piperadinylen-(CH ２ ) ４ -, - (CH ２ ) ６ -Piperadinylen-(CH ２ ) ５ -, - (CH ２ ) ６ -Piperadinylen-(CH ２ ) ６ -, - (CH ２ ) ６ -Piperadinylen-(CH ２ ) ７ -, - (CH ２ ) ６ -Piperadinylen-(CH ２ ) ８ -, - (CH ２ ) ７ -Piperadinylen-(CH ２ ) １ -, - (CH ２ ) ７ -Piperadinylen-(CH ２ ) ２ -, - (CH ２ ) ７ -Piperadinylen-(CH ２ ) ３ -, - (CH ２ ) ７ -Piperadinylen-(CH ２ ) ４ -, - (CH ２ ) ８ -Piperadinylen-CH ２ -, - (CH ２ ) ８ -Piperadinylen-(CH ２ ) ２ -, - (CH ２ ) ８ -Piperadinylen-(CH ２ ) ３ -, - (CH ２ ) ８ -Piperadinylen-(CH ２ ) ４ -, - (CH ２ ) ８ -Piperadinylen-(CH ２ ) ５ - or - (CH ２ ) ８ -Piperadinylen-(CH ２ ) ６ - represents; Here, each R ａ７ H or C １－３ Represents alkyl; The phenylene, piperazinylene, and piperidylene each independently further contain a deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, oxo group, and C １－６ Alkyl, halogenated C １－６ Alkyl, deuterated C １－６ Alkyl, C １－６ Alkoxy, C halogenated １－６ Alkoxy, C ３－６ Cycloalkyl, halogenated C ３－６ Cycloalkyl, deuterated C ３－６A compound of formula (I) according to any one of claims 11 to 13, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph, which is optionally substituted with substituents selected from the group consisting of cycloalkyls, 4- to 10-membered heterocyclines, and any combination thereof.

15. Also, the following equations (I-1), (I-2), (I-3), (I-4), (I-5), (I-6), (I-7), (I-8-1), (I-8-2), (I-8-3), (I-8-4), (I-9), (I-10), (I-11), (I-12), (I-13), (I-14), (I-15), (I-16), (I-17), (I-18), (I-19), (I-20-1), (I-20-2), (I-20-3), (I-20-4), (I-21-1), (I-21-2), (I-22), (I-23), (I-24), (I-25-1), (I- 25-2), Structure of formulas (I-26), (I-27), (I-28), (I-29), (I-30), (I-31), (I-32), (I-33), (I-34-1), (I-34-2), (I-35), (I-36), (I-37), (I-38), (I-39-1), (I-39-2), (I-40), (I-41), (I-42), (I-43), (I-44), (I-45), (I-46), (I-47), (I-48), (I-49), (I-50), (I-51), (I-52), (I-53), (I-54), or (I-55): [C182] [C183] [C184] [C185] [C186] [C187] [C188] [C189] [C190] [C191] [C192] [C193] [C194] [C195] [C196] [C197] [C198] [C199] [C200] [chemical 201] [C202] [C203] [C204] [C205] [C206] [C207] [C208] [C209] [C210] [C211] [C212] [C213] or [C214] It is represented by; In the formula, A, R ａ１ , R ａ２ , R ａ３ , R ａ４ , X, ring W １ , (R ａ５ ) ｍ , LIN, R ｃ , (R １ａ ) ｐ１ａ , R １ｂ , (R １ｃ ) ｐ１ｂ , R １ｄ , (R ２ａ ) ｐ２ａ , (R ２ｂ ) ｐ２ｂ , R ２ｃ , (R ３ａ ) ｐ３ａ , R ３ｂ , R ４ａ , R ４ｂ , (R ４ｃ ) ｐ４ａ , R ５ａ , R ５ｂ , ring A, ring B, ring C, R ７ａ , (R ７ｂ ) ｐ７ａ , R ８ａ , R ８ｂ , (R ８ｃ ) ｐ８ａ , R ８ｄ , R ８ｅ , X １ , X ２ , X ３ , R ９ａ , R ９ｂ , (R ９ｃ ) ｐ９ａ , (R ９ｄ ) ｐ９ｂ , X ４ , X ５ , X ６ , X ７ , (R １０ａ ) ｐ１０ａ , (R １０ｂ ) ｐ１０ｂ , R １０ｃ , R １０ｄ , (R １１ａ ) ｐ１１ａ , R １１ｂ , R １１ｃ , R １２ａ , R １２ｂ , (R １２ｃ ) ｐ１２ａ , R １２ｄ , X ８ , X ９ , X １０ , X １１ , X １２ , (R １３ａ ) ｐ１３ａ , (R １４ａ ) ｐ１４ａ , R １４ｂ , (R １５ａ ) ｐ１５ａ 、(R １５ｂ ) ｐ１５ｂ 、R １６ａ 、(R １６ｂ ) ｐ１６ａ 、(R １６ｃ ) ｐ１６ｂ 、(R １７ａ ) ｐ１７ａ 、R １７ｂ 、(R １８ａ ) ｐ１８ａ 、(R １８ｂ ) ｐ１８ｂ 、R １９ａ 、R １９ｂ 、(R １９ｃ ) ｐ１９ａ 、(R １９ｄ ) ｐ１９ｂ 、R ２０ａ 、R ２０ｂ 、R ２０ｃ 、R ２０ｄ 、(R ２０ｅ ) ｐ２０ａ 、R ２１ａ 、R ２１ｂ 、(R ２１ｃ ) ｐ２１ａ 、R ２１ｄ 、R ２２ａ 、R ２２ｂ 、Ring E, R ２３ａ 、R ２３ｂ 、(R ２４ａ ) ｐ２４ａ 、(R ２４ｂ ) ｐ２４ｂ 、y, (R ２５ａ ) ｐ２５ａ 、R ２５ｂ 、R ２５ｃ 、R ２５ｄ 、R ２５ｅ 、R ２５ｆ 、R ２５ｇ 、R ２５ｉ 、R ２６ａ 、R ２６ｂ 、(R ２６ｃ ) ｐ２６ａ 、R ２７ａ 、R ２７ｂ 、R ２７ｃ 、R ２７ｄ 、R ２８ａ 、(R ２８ｂ ) ｐ２８ａ 、R ２８ｃ 、R ２８ｄ 、(R ２８ｅ ) ｐ２８ｂ 、R ２９ａ 、R ２９ｂ , R ２９ｃ , R ２９ｄ , R ２９ｅ , R ３０ａ , R ３０ｂ , R ３０ｃ , R ３０ｄ , (R ３０ｅ ) ｐ３０ａ , R ３１ａ , R ３１ｂ , R ３１ｃ , R ３１ｄ , (R ３１ｅ ) ｐ３１ａ , (R ３１ｆ ) ｐ３１ｂ , kF, (R ３２ａ ) ｐ３２ａ , (R ３２ｂ ) ｐ３２ｂ , R ３２ｃ , R ３２ｄ , R ３２ｅ , (R ３３ａ ) ｐ３３ａ , (R ３３ｂ ) ｐ３３ｂ , R ３３ｃ , R ３３ｄ , (R ３３ｅ ) ｐ３３ｃ , X １３ , X １４ , X １５ , Ring G, R ３４ａ , R ３４ｂ , R ３４ｃ , (R ３４ｄ ) ｐ３４ａ , (R ３４ｅ ) ｐ３４ｂ , X １６ , X １７ , X １８ , (R ３５ａ ) ｐ３５ａ , R ３５ｂ , (R ３５ｃ ) ｐ３５ｂ , (R ３６ａ ) ｐ３６ａ , (R ３６ｂ ) ｐ３６ｂ , (R ３７ａ ) ｐ３７ａ , (R ３７ｂ ) ｐ３７ｂ , (R ３８ａ ) ｐ３８ａ , R ３８ｂ , R ３８ｃ , R ３８ｄ , R ３９ａ , R ３９ｂ , R ３９ｃ , R ３９ｄ , y1, (R ４０ａ ) ｐ４０ａ , R ４１ａ , R ｘ３ , R ４１ｂ , R ４１ｃ , (R ４１ｄ ) ｐ４１ａ , (R ４２ａ ) ｐ４２ａ , R ４２ｂ , (R ４２ｃ ) ｐ４２ｂ , (R ４３ａ ) ｐ４３ａ , R ４３ｂ , ring H, R ４４ａ , R ４４ｂ , R ４４ｃ , R ４４ｄ , (R ４４ｅ ) ｐ４４ａ , (R ４４ｆ ) ｐ４４ｂ , (R ４４ｇ ) ｐ４４ｃ , (R ４５ａ ) ｐ４５ａ , (R ４５ｂ ) ｐ４５ｂ , R ｃ１ , R ４６ａ , (R ４６ｂ ) ｐ４６ａ , (R ４６ｃ ) ｐ４６ｂ , R ４７ａ , R ４７ｂ , R ４７ｃ , (R ４７ｄ ) ｐ４７ａ , (R ４７ｅ ) ｐ４７ｂ , (R ４７ｆ ) ｐ４７ｃ , ring I, R ４８ａ , R ４８ｂ , R ４８ｃ , (R ４８ｄ ) ｐ４８ａ , R ４８ｅ , R ４８ｆ , R ４９ａ , R ４９ｂ , (R ４９ｃ ) ｐ４９ａ , (R ４９ｄ ) ｐ４９ｂ , ring J, (R ５０ａ ) ｐ５０ａ , R ５０ｂ , (R ５１ａ ) ｐ５１ａ , (R ５１ｂ ) ｐ５１ｂ , (R ５１ｃ ) ｐ５１ｃ , (R ５２ａ ) ｐ５２ａ , (R ５２ｂ ) ｐ５２ｂ , (R ５２ｃ ) ｐ５２ｃ , (R ５２ｄ ) ｐ５２ｄ , (R ５２ｅ ) ｐ５２ｅ , R ５２ｆ , (R ５３ａ ) ｐ５３ａ , (R ５３ｂ ) ｐ５３ｂ , R ５３ｃ , (R ５４ａ ) ｐ５４ａ , (R ５４ｂ ) ｐ５４ｂ , (R ５５ａ ) ｐ５５ａ , R ５５ｂ , R ５５ｃ and R ５５ｄ The compound of formula (I) described in claim 1, or a salt thereof, enantiomer, stereoisomer, solvate, isotope-enriched analog, pharmaceutical precursor, or polymorph, as defined in claim 3.

16. N-(2-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)ethyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(4-(2,6-dioxopiperidine-3-yl)benzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(3-(2,6-dioxopiperidine-3-yl)benzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(2,6-dioxopiperidine-3-yl)benzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; N-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)-4,9-dioxo-4,9-dihydronaphtho[2,3-b]furan-2-carboxamide; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-(2,6-dioxopiperidine-3-yl)benzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(3-(2,6-dioxopiperidine-3-yl)benzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(2-(2,6-dioxopiperidine-3-yl)benzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(2-chloro-3-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((2S)-5-amino-1-(2-chloro-3-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)phenoxy)-5-oxopentan-2-yl)carbamoyl)-3-methyl-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; ((2-(((5S,8S,10aR)-8-(((S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl)carbamoyl)-3-((1-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)methyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazosin-5-yl)carbamoyl)-1H-indole-5-yl)difluoromethyl)phosphonic acid; 6-(1-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(1-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((4-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((3-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((2-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((4-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((3-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-((2-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 6-(4-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)piperidine-1-yl)-2-(4-phenoxyphenyl)nicotinamide; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluorophenyl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluorophenyl)piperidine-2,6-dione; 3-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluorophenyl)piperidine-2,6-dione; 3-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluorophenyl)piperidine-2,6-dione; 3-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluorophenyl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluorophenyl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluorophenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluorophenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluorophenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluorophenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluorophenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluorophenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluorophenyl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluorophenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluorophenyl)amino)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-3-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-3-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-3-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluoropyridine-3-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluoropyridine-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-2-yl)piperidine-2,6-dione; 3-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-2-yl)piperidine-2,6-dione; 3-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-2-yl)piperidine-2,6-dione; 3-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-2-yl)piperidine-2,6-dione; 3-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-3-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-3-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-3-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluoropyridine-3-yl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-3-yl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-3-yl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-3-yl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluoropyridine-3-yl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-2-yl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluoropyridine-2-yl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-2-yl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-2-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-3-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridazine-3-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridazine-3-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-4-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridazine-4-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluoropyridazine-4-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrimidine-4-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrazine-2-yl)piperidine-2,6-dione; 3-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrazine-2-yl)piperidine-2,6-dione; 3-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-3-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-3-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrimidine-2-yl)piperidine-2,6-dione; 3-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrimidine-4-yl)piperidine-2,6-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluoropyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluoropyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-4-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridazine-4-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluoropyridazine-4-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrimidine-4-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrazine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrazine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrimidine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrimidine-4-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-3-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-3-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-3-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluoropyridine-3-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-2-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-2-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluoropyridine-2-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-2-yl)amino)piperidine-2,6-dione; 3-((3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-2-yl)amino)piperidine-2,6-dione; 3-((3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-2-yl)amino)piperidine-2,6-dione; 3-((3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-2-yl)amino)piperidine-2,6-dione; 3-((3-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-2-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-3-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridine-3-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-3-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluoropyridine-3-yl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-3-yl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-3-yl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-3-yl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-2-fluoropyridine-3-yl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridine-2-yl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluoropyridine-2-yl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridine-2-yl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-6-fluoropyridine-2-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-3-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridazine-3-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-4-fluoropyridazine-3-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-4-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-5-fluoropyridazine-4-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)-3-fluoropyridazine-4-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrimidine-4-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrazine-2-yl)amino)piperidine-2,6-dione; 3-((6-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrazine-2-yl)amino)piperidine-2,6-dione; 3-((4-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazine-3-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyridazin-3-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrimidine-2-yl)amino)piperidine-2,6-dione; 3-((5-((4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)piperidine-1-yl)methyl)pyrimidine-4-yl)amino)piperidine-2,6-dione; 3-(4-(((3R,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)-3-fluoropiperidine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-(((3R,4S)-4-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-1-yl)-3-fluoropiperidine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-((4-(1-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-3-fluorobenzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)phenyl)amino)-5-(piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperidine-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; (R)-3-((4-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-(3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; (R)-3-((4-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperidine-4-yl)phenyl)amino)-5-(3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; (R)-3-((4-(1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-3-fluorobenzyl)piperidine-4-yl)phenyl)amino)-5-(3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; (R)-3-((4-(1-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-(3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; (R)-3-((4-(1-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)phenyl)amino)-5-(3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; (R)-3-((4-(1-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperidine-4-yl)phenyl)amino)-5-(3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; (R)-3-((4-(1-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperidine-4-yl)phenyl)amino)-5-(3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; (R)-3-((4-(1-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperidine-4-yl)phenyl)amino)-5-(3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; 3-((4-(1-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)phenyl)amino)-5-((R)-3-(3-methyl-2-oxoimidazolidine-1-yl)piperidine-1-yl)pyrazine-2-carboxamide; 3-(4-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-(1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(3-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-(1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-(4-chloro-1,2-bis(4-hydroxyphenyl)buta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-(4-chloro-1-(4-hydroxyphenyl)-2-phenylbuta-1-en-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(3-((4-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(3-((4-(4-(((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(3-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-(((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-(((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-(((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-(((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((4-((4-(((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-(((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(3-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 1-(4-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-(((1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(1-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-((4-(1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-((4-(1-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(1-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((4-(1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((4-(1-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-fluoro-4-((4-(1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-fluoro-4-((4-(1-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(1-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((3-((4-(1-(4-((1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(1-(4-((1S,2R)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(2-fluoro-4-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(3-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(1-(4-(6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalene-1-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(3-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(3-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((4-((4-(((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-((3S,4R)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-((3R,4S)-7-hydroxy-3-phenylchroman-4-yl)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(3-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 1-(4-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-(((1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(3-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(1-(4-(7-hydroxy-3-phenylchroman-4-yl)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(4-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)piperidine-2,6-dione; 1-(4-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-(((1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazine-6-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(3-(6-(4-amino-4-methylpiperidine-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(4-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)phenyl)piperidine-2,6-dione; 1-(4-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-(((3-((3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)thio)-2-chlorophenyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(3-(3-amino-5-(4-amino-4-methylpiperidine-1-yl)pyrazine-2-yl)-2-chlorophenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(4-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)phenyl)piperidine-2,6-dione; 1-(4-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((((3S,4S)-8-(6-amino-5-((2-amino-3-chloropyridine-4-yl)thio)pyrazine-2-yl)-3-methyl-2-oxa-8-azaspiro[4.5]decane-4-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4,5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4,5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4,5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4,5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4,5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4,5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4,5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decane-8-yl)pyrazine-2-yl)thio)pyridine-2-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(4-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)piperidine-2,6-dione; 1-(4-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-(((1-(6-amino-5-(2,3-dichlorophenyl)pyrazine-2-yl)-4-methylpiperidine-4-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)phenyl)piperidine-2,6-dione; 3-(4-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)phenyl)piperidine-2,6-dione; 3-(2-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)phenyl)piperidine-2,6-dione; 1-(4-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((2,3-difluoro-6-(2-morpholinothiazole-4-yl)phenoxy)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)piperidine-2,6-dione; 3-(3-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)piperidine-2,6-dione; 3-(2-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)piperidine-2,6-dione; 1-(4-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-fluoro-4-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((2-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-4-yl)-4-(methylsulfonyl)phenoxy)methyl)phenyl)amino)piperidine-2,6-dione; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-3-fluorobenzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)piperidine-1-yl)pyridazin-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)piperidine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)pyridazin-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)nicotinamide; N-((1r,3r)-3-(3-chloro-4-cyanophenoxy)-2,2,4,4-tetramethylcyclobutyl)-6-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)nicotinamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-3-fluorobenzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)pyridazin-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; N-((1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl)-6-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)pyridazine-3-carboxamide; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-3-fluorobenzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-3-yl)methyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(4-((5-(3,5-dimethylisoxazole-4-yl)-2-methylphenyl)((1-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperidine-4-yl)methyl)amino)phenyl)cyclopropane-1-carbonitrile; 1-(5-((4-chloro-2-(7-chloro-5-(trifluoromethyl)-1H-benzo[d]imidazole-2-yl)phenoxy)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-chloro-2-(7-chloro-5-(trifluoromethyl)-1H-benzo[d]imidazole-2-yl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-chloro-2-(7-chloro-5-(trifluoromethyl)-1H-benzo[d]imidazole-2-yl)phenoxy)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 3-(4-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(6-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)pyridine-3-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(6-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)pyridazine-3-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((((1-(4-((9-Cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)phenyl)piperidin-2,6-dione; 3-(4-((((1-(4-((9-Cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-2-fluorophenyl)piperidin-2,6-dione; 3-(3-((((1-(4-((9-Cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)phenyl)piperidin-2,6-dione; 3-(2-((((1-(4-((9-Cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)phenyl)piperidin-2,6-dione; 1-(4-((((1-(4-((9-Cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((((1-(4-((9-Cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((((1-(4-((9-Cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((((1-(4-((9-Cyclopentyl-8-(phenylamino)-9H-purin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-(((1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-4,9-dihydro-3H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(1-(4-((9-cyclopentyl-8-(phenylamino)-9H-purine-2-yl)amino)phenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-fluoro-4-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(3-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)piperidine-2,6-dione; 1-(4-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-fluoro-4-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-(((5-methoxy-4-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)-2-nitrophenyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; N-(2-((2-((4-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((3-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((2-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-3-fluorobenzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-(((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-(((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-(((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((4-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((3-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; N-(2-((2-((2-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indole-3-yl)pyrimidine-2-yl)amino)phenyl)acrylamide; 3-(4-((4-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)propyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)propyl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)propyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)propyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)propyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)propyl)piperazine-1-yl)methyl)-2-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)propyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)propyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)propyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)methyl)pyridin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(4-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)propoxy)quinazolin-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(4-(2,6-dioxopiperidin-3-yl)-3-fluorobenzyl)piperazin-1-yl)propoxy)quinazolin-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(3-(2,6-dioxopiperidin-3-yl)benzyl)piperazin-1-yl)propoxy)quinazolin-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-3-fluorobenzyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)propoxy)quinazoline-6-yl)acrylamide; 3-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)oxy)piperidine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(4-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)phenyl)piperidine-2,6-dione; (S)-1-(4-(((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; (S)-1-(4-(((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; (S)-1-(3-(((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; (S)-1-(2-(((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; (S)-1-(6-(((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; (S)-1-(6-(((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; (S)-1-(4-(((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-(((4-(((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-(((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazoline-6-yl)amino)methyl)phenyl)amino)piperidine-2,6-dione; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)buta-2-enamide; (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazoline-6-yl)-4-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)buta-2-enamide; 3-(4-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(4-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 3-(2-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)piperidine-2,6-dione; 1-(4-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)pyridazine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-(((1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)(methyl)amino)methyl)phenyl)amino)piperidine-2,6-dione; 3-(4-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(4-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)-2-fluorophenyl)piperidine-2,6-dione; 3-(3-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 3-(2-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)piperidine-2,6-dione; 1-(4-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)-3-fluorophenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(3-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(2-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(5-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-2-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(6-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridazin-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 1-(4-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)pyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 3-((4-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((3-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 3-((2-((4-(1-(4-((5-bromo-4-((5-(dimethylphosphoryl)quinoxaline-6-yl)amino)pyrimidine-2-yl)amino)-5-methoxy-2-methylphenyl)piperidine-4-yl)piperazine-1-yl)methyl)phenyl)amino)piperidine-2,6-dione; 2-(7-((4-(2,6-dioxopiperidine-3-yl)benzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((3-(2,6-dioxopiperidine-3-yl)benzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((2-(2,6-dioxopiperidine-3-yl)benzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-(((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-(((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-(((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((4-((2,6-dioxopiperidine-3-yl)amino)benzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((3-((2,6-dioxopiperidine-3-yl)amino)benzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(7-((2-((2,6-dioxopiperidine-3-yl)amino)benzyl)amino)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((4-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((3-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((2-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((5-(2,6-dioxopiperidine-3-yl)-2-fluoropyridine-3-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((4-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((3-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-((2-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)piperidine-1-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)phenyl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)phenyl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)phenyl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)phenyl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)phenyl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)phenyl)-1-oxoisoindoline-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)phenyl)-1-oxoisoindoline-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)phenyl)-1-oxoisoindoline-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)phenyl)-1-oxoisoindoline-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)phenyl)-1-oxoisoindoline-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)phenyl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)phenyl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)phenyl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(4-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)phenyl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)pyridazine-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)pyridazine-3-yl)-1-oxoisoindoline-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)pyridazine-3-yl)-1-oxoisoindoline-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6-(6-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)pyridazin-3-yl)-1-oxoisoindorin-2-yl)-2-(5-fluoro-2-hydroxyphenyl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(2-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((2-(2,6-dioxopiperidine-3-yl)pyridine-4-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((5-(2,6-dioxopiperidine-3-yl)pyridine-2-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((5-(2,6-dioxopiperidine-3-yl)pyridine-3-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((5-(2,6-dioxopiperidine-3-yl)-2-fluoropyridine-3-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-5-fluoropyridine-4-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((6-(2,4-pyrrolo[1,2-c]imidazole-1(2H)-yl)pyridine-3-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-3-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 1-(5-((4-(4-(2-(1-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(thiazole-2-group amino)ethyl)-7-fluoro-3-oxoisoindoline-5-yl)phenyl)piperazine-1-yl)methyl)-6-fluoropyridine-3-yl)dihydropyrimidine-2,4(1H,3H)-dione; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyrazine-2-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((2-((2,6-dioxopiperidine-3-yl)amino)pyridine-3-yl)methyl)piperazine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(4-(2,6-dioxopiperidine-3-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(3-(2,6-dioxopiperidine-3-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(2-(2,6-dioxopiperidine-3-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1S,4S)-5-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(4-(2,6-dioxopiperidine-3-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(3-(2,6-dioxopiperidine-3-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(2-(2,6-dioxopiperidine-3-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((2-(2,6-dioxopiperidine-3-yl)pyridine-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((2-(2,6-dioxopiperidine-3-yl)-5-fluoropyridine-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((5-(2,6-dioxopiperidine-3-yl)pyridine-2-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((5-(2,6-dioxopiperidine-3-yl)pyridine-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((5-(2,6-dioxopiperidine-3-yl)-2-fluoropyridine-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-3-fluoropyridine-2-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-5-fluoropyridine-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluoropyridine-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyrazine-2-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyrazine-2-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-((1R,4R)-5-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(4-(2,6-dioxopiperidine-3-yl)benzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(3-(2,6-dioxopiperidine-3-yl)benzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(2-(2,6-dioxopiperidine-3-yl)benzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(4-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-3-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(4-((2,6-dioxopiperidine-3-yl)amino)benzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(3-((2,6-dioxopiperidine-3-yl)amino)benzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(8-(2-((2,6-dioxopiperidine-3-yl)amino)benzyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((4-((2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((4-((2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((3-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((2-(2,6-dioxopiperidine-3-yl)benzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((2-(2,6-dioxopiperidine-3-yl)pyridine-4-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((2-(2,6-dioxopiperidine-3-yl)-5-fluoropyridine-4-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((5-(2,6-dioxopiperidine-3-yl)pyridine-2-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((5-(2,6-dioxopiperidine-3-yl)pyridine-3-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((4-((2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((4-((2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluorobenzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)benzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-2-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-3-fluoropyridine-2-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((2-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-5-fluoropyridine-4-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-3-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-3-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)-2-fluoropyridine-3-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridazin-3-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((5-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyrazine-2-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((6-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyrazine-2-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((3-(2,4-dioxotetrahydropyrimidine-1(2H)-yl)pyridine-4-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((4-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((3-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-((2-((2,6-dioxopiperidine-3-yl)amino)benzyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(((2-(((2,6-dioxopiperidine-3-yl)amino)pyridine-3-yl)methyl)(methyl)amino)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(4-(4-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(4-(4-(4-(2,6-dioxopiperidine-3-yl)-3-fluorobenzyl)piperazine-1-yl)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazole-1-yl)-2-(6-(4-(4-(4-(3-(2,6-dioxopiperidine-3-yl)benzyl)piperazine-1-yl)piperidine-1-yl)phenyl)-4-fluoro-1-oxoisoindorin-2-yl)-N-(thiazole-2-yl)acetamide; ...

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